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Patent code US10829502

Compile Data Set for Download or QSAR
Found 125 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394289
PNG
(US10428087, Example 8 | US10829502, Example 8 | US...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
PDB
MMDB

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US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US10428087, Example 9 | US10829502, Example 9 | US...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394344
PNG
(US10428087, Example 64 | US10829502, Example 64 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(C)cc1
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US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394338
PNG
(US10428087, Example 58 | US10829502, Example 58 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1Cl
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394330
PNG
(US10428087, Example 50 | US10829502, Example 50 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394329
PNG
(US10428087, Example 49 | US10829502, Example 49 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM415502
PNG
(US10428087, Example 43 second peak | US10829502, E...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1Cl
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394301
PNG
(US10428087, Example 21 | US10829502, Example 21 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cscn1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US10428087, Example 44 | US10829502, Example 44 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM124076
PNG
(US10428087, Example 71 | US10829502, Example 71 | ...)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)/t13-/m1/s1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394334
PNG
(US10428087, Example 54 | US10829502, Example 54 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(Cl)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US10428087, Example 23 | US10829502, Example 23 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394340
PNG
(US10428087, Example 60 | US10829502, Example 60 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1F
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US10428087, Example 44 | US10829502, Example 44 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394300
PNG
(US10428087, Example 20 | US10829502, Example 20 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1nccs1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1
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US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394358
PNG
(US10428087, Example 78 | US10829502, Example 78 | ...)
Show SMILES CCc1cccc2nc(C(C)Nc3ncnc4[nH]cnc34)c(-c3ccc(F)cc3)c(=O)n12
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394337
PNG
(US10428087, Example 57 | US10829502, Example 57 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1Cl
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US10428087, Example 23 | US10829502, Example 23 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US10428087, Example 23 | US10829502, Example 23 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394320
PNG
(US10428087, Example 40 | US10829502, Example 40 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1F
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394326
PNG
(US10428087, Example 46 | US10829502, Example 46 | ...)
Show SMILES C[C@H](Nc1ccnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394347
PNG
(US10428087, Example 67 | US10829502, Example 67 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)ccc1F
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394353
PNG
(US10428087, Example 73 | US10829502, Example 73 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US10428087, Example 11 | US10829502, Example 11 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394313
PNG
(US10428087, Example 33 | US10829502, Example 33 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1F
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US10428087, Example 11 | US10829502, Example 11 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US10428087, Example 44 | US10829502, Example 44 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394332
PNG
(US10428087, Example 52 | US10829502, Example 52 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(C)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394339
PNG
(US10428087, Example 59 | US10829502, Example 59 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1F
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394345
PNG
(US10428087, Example 65 | US10829502, Example 65 | ...)
Show SMILES COc1cccc(c1)-c1c(nc2cccc(C)n2c1=O)C(C)Nc1ncnc2[nH]cnc12
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394354
PNG
(2-{1-[(2-Amino-9H-purin-6-yl)amino]ethyl}-3-(3-flu...)
Show SMILES C[C@@H](Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US10428087, Example 9 | US10829502, Example 9 | US...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM415494
PNG
(US10428087, Example 39 second peak | US10829502, E...)
Show SMILES C[C@H](Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1Cl
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394325
PNG
(US10428087, Example 45 | US10829502, Example 45 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)ccc1F
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394346
PNG
(US10428087, Example 66 | US10829502, Example 66 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1F
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394283
PNG
(US10428087, Example 2 | US10829502, Example 2 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US10428087, Example 44 | US10829502, Example 44 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1
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Patents


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US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394314
PNG
(US10428087, Example 34 | US10829502, Example 34 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1F
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394295
PNG
(US10428087, Example 14 | US10829502, Example 14 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccn1
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n/an/a 75n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394357
PNG
(US10428087, Example 77 | US10829502, Example 77 | ...)
Show SMILES CCc1cccc2nc(C(C)Nc3nc(N)nc4[nH]cnc34)c(-c3cc(F)cc(F)c3)c(=O)n12
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US10428087, Example 9 | US10829502, Example 9 | US...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394288
PNG
(US10428087, Example 7 | US10829502, Example 7 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cn[nH]c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394312
PNG
(US10428087, Example 32 | US10829502, Example 32 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(Cl)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394286
PNG
(US10428087, Example 5 | US10829502, Example 5 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394295
PNG
(US10428087, Example 14 | US10829502, Example 14 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccn1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394285
PNG
(US10428087, Example 4 | US10829502, Example 4 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394289
PNG
(US10428087, Example 8 | US10829502, Example 8 | US...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
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n/an/a 75n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394364
PNG
(US10428087, Example 84aResults | US10829502, Examp...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(c1)C#N
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n/an/a 75n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM124079
PNG
(US10428087, Example 70 | US10829502, Example 70 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)
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US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394283
PNG
(US10428087, Example 2 | US10829502, Example 2 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394328
PNG
(US10428087, Example 48 | US10829502, Example 48 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(n2c(=O)c1-c1cccc(F)c1)C(F)(F)F
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394321
PNG
(US10428087, Example 41 | US10829502, Example 41 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1F
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394302
PNG
(US10428087, Example 22 | US10829502, Example 22 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccc(F)cc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394315
PNG
(US10428087, Example 35 | US10829502, Example 35 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(Cl)c1
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n/an/a 75n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394318
PNG
(US10428087, Example 38 | US10829502, Example 38 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cncc(F)c1
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n/an/a 75n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394284
PNG
(US10428087, Example 3 | US10829502, Example 3 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cncc(F)c1
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394317
PNG
(US10428087, Example 37 | US10829502, Example 37 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(Cl)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394342
PNG
(US10428087, Example 62 | US10829502, Example 62 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(cc1)C#N
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394348
PNG
(US10428087, Example 68 | US10829502, Example 68 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(F)c(F)c1
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394298
PNG
(US10428087, Example 18 | US10829502, Example 18 | ...)
Show SMILES CC(Nc1nc(F)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394282
PNG
(US10428087, Example 1 | US10829502, Example 1 | US...)
Show SMILES CC(c1nc2cccc(C)n2c(=O)c1-c1ccccc1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H19N7O/c1-13-7-6-10-16-27-18(17(22(30)29(13)16)15-8-4-3-5-9-15)14(2)28-12-26-19-20(23)24-11-25-21(19)28/h3-12,14H,1-2H3,(H2,23,24,25)
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394284
PNG
(US10428087, Example 3 | US10829502, Example 3 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cncc(F)c1
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US10428087, Example 23 | US10829502, Example 23 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394307
PNG
(US10428087, Example 27 | US10829502, Example 27 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1ccccc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394286
PNG
(US10428087, Example 5 | US10829502, Example 5 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394297
PNG
(US10829502, Example 17 | US9975907, Example 17)
Show SMILES CC(Nc1ncnc2[nH]ccc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394306
PNG
(US10428087, Example 26 | US10829502, Example 26 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cccc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394285
PNG
(US10428087, Example 4 | US10829502, Example 4 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394299
PNG
(US10428087, Example 19 | US10829502, Example 19 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccncc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394316
PNG
(US10428087, Example 36 | US10829502, Example 36 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(Cl)c1
PDB
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM415499
PNG
(6-(2-chlorophenyl)-3-methyl-7-[1-(9H-purin-6-ylami...)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1Cl
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394331
PNG
(US10428087, Example 51 | US10829502, Example 51 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(C)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394343
PNG
(US10428087, Example 63 | US10829502, Example 63 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1C
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394363
PNG
(US10428087, Example 83 | US10829502, Example 83 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(c1)C#N
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394287
PNG
(US10428087, Example 6 | US10829502, Example 6 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccnc1F
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394288
PNG
(US10428087, Example 7 | US10829502, Example 7 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cn[nH]c1
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US10428087, Example 11 | US10829502, Example 11 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394311
PNG
(US10428087, Example 31 | US10829502, Example 31 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccc(C)cc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM415493
PNG
(7-{1-[(2-amino-9H-purin-6-yl)amino]ethyl}-6-(2-chl...)
Show SMILES C[C@@H](Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1Cl
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394333
PNG
(US10428087, Example 53 | US10829502, Example 53 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(Cl)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394282
PNG
(US10428087, Example 1 | US10829502, Example 1 | US...)
Show SMILES CC(c1nc2cccc(C)n2c(=O)c1-c1ccccc1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H19N7O/c1-13-7-6-10-16-27-18(17(22(30)29(13)16)15-8-4-3-5-9-15)14(2)28-12-26-19-20(23)24-11-25-21(19)28/h3-12,14H,1-2H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394287
PNG
(US10428087, Example 6 | US10829502, Example 6 | US...)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccnc1F
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394322
PNG
(US10428087, Example 42 | US10829502, Example 42 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cncc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394327
PNG
(US10428087, Example 47 | US10829502, Example 47 | ...)
Show SMILES C[C@H](Nc1nc(O)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394349
PNG
(US10428087, Example 69 | US10829502, Example 69 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394356
PNG
(US10428087, Example 76 | US10829502, Example 76 | ...)
Show SMILES CCc1cccc2nc(C(C)Nc3ncnc4[nH]cnc34)c(-c3cc(F)cc(F)c3)c(=O)n12
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394360
PNG
(US10428087, Example 80 | US10829502, Example 80 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2ccccn2c(=O)c1-c1cc(F)cc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US10428087, Example 23 | US10829502, Example 23 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394305
PNG
(US10428087, Example 25 | US10829502, Example 25 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cc(F)cc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM124077
PNG
(US10428087, Example 72 | US10829502, Example 72 | ...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)/t13-/m0/s1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US10428087, Example 11 | US10829502, Example 11 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394308
PNG
(US10428087, Example 28 | US10829502, Example 28 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cccc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394341
PNG
(US10428087, Example 61 | US10829502, Example 61 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(cc1)C#N
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394361
PNG
(US10428087, Example 81 | US10829502, Example 81 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cnc(Cl)c(C)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394309
PNG
(US10428087, Example 29 | US10829502, Example 29 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1ccccc1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394362
PNG
(US10428087, Example 82 | US10829502, Example 82 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cnc(Cl)c(C)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US10428087, Example 44 | US10829502, Example 44 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394335
PNG
(US10428087, Example 55 | US10829502, Example 55 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(Cl)cc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US10428087, Example 44 | US10829502, Example 44 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394336
PNG
(US10428087, Example 56 | US10829502, Example 56 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(Cl)cc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US10428087, Example 23 | US10829502, Example 23 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394355
PNG
(US10428087, Example 75 | US10829502, Example 75 | ...)
Show SMILES C[C@H](Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394359
PNG
(US10428087, Example 79 | US10829502, Example 79 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2ccccn2c(=O)c1-c1cc(F)cc(F)c1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US10428087, Example 9 | US10829502, Example 9 | US...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US10428087, Example 9 | US10829502, Example 9 | US...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US10428087, Example 44 | US10829502, Example 44 | ...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM124076
PNG
(US10428087, Example 71 | US10829502, Example 71 | ...)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)/t13-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US10428087, Example 11 | US10829502, Example 11 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US10428087, Example 23 | US10829502, Example 23 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM394304
PNG
(US10428087, Example 24 | US10829502, Example 24 | ...)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cc(F)cc(F)c1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
PDB
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...


US Patent US10829502 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%