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Patent code US10836720

Compile Data Set for Download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472699
PNG
(US10836720, HIJ-1483)
Show SMILES NC(=N)Nc1cc(NC(=O)CCCNC(=O)C23CC4CC(CC(C4)C2)C3)cc(c1)C(=O)NCC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C39H51N9O9S/c40-38(41)46-28-16-26(15-27(17-28)45-32(49)9-4-10-42-37(55)39-18-23-12-24(19-39)14-25(13-23)20-39)34(51)44-22-33(50)43-21-30(36(53)54)47-35(52)31-8-5-11-48(31)58(56,57)29-6-2-1-3-7-29/h1-3,6-7,15-17,23-25,30-31H,4-5,8-14,18-22H2,(H,42,55)(H,43,50)(H,44,51)(H,45,49)(H,47,52)(H,53,54)(H4,40,41,46)/t23?,24?,25?,30-,31-,39?/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472684
PNG
(US10836720, HIJ-1018)
Show SMILES NC(=N)NCCCCCCNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C22H35N7O6S/c23-21(24)25-12-6-1-2-7-13-26-22(33)27-15-17(20(31)32)28-19(30)18-11-8-14-29(18)36(34,35)16-9-4-3-5-10-16/h3-5,9-10,17-18H,1-2,6-8,11-15H2,(H,28,30)(H,31,32)(H4,23,24,25)(H2,26,27,33)/t17-,18-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472692
PNG
(US10836720, HIJ-1204)
Show SMILES NC(=N)Nc1cccc(c1)C(=O)NCC(=O)NC[C@H](NC(=O)C1C2CCC(CC2)N1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H33N7O7S/c28-27(29)32-18-6-4-5-17(13-18)24(36)31-15-22(35)30-14-21(26(38)39)33-25(37)23-16-9-11-19(12-10-16)34(23)42(40,41)20-7-2-1-3-8-20/h1-8,13,16,19,21,23H,9-12,14-15H2,(H,30,35)(H,31,36)(H,33,37)(H,38,39)(H4,28,29,32)/t16?,19?,21-,23?/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472698
PNG
(US10836720, HIJ-1437)
Show SMILES NCCCC(=O)Nc1cc(NC(N)=N)cc(c1)C(=O)NCC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C28H37N9O8S/c29-10-4-9-23(38)34-18-12-17(13-19(14-18)35-28(30)31)25(40)33-16-24(39)32-15-21(27(42)43)36-26(41)22-8-5-11-37(22)46(44,45)20-6-2-1-3-7-20/h1-3,6-7,12-14,21-22H,4-5,8-11,15-16,29H2,(H,32,39)(H,33,40)(H,34,38)(H,36,41)(H,42,43)(H4,30,31,35)/t21-,22-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472690
PNG
(US10836720, HIJ-1099)
Show SMILES NC(=N)Nc1cccc(c1)C(=O)NNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H28N8O7S/c24-22(25)27-15-7-4-6-14(12-15)19(32)29-30-23(36)26-13-17(21(34)35)28-20(33)18-10-5-11-31(18)39(37,38)16-8-2-1-3-9-16/h1-4,6-9,12,17-18H,5,10-11,13H2,(H,28,33)(H,29,32)(H,34,35)(H4,24,25,27)(H2,26,30,36)/t17-,18-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472676
PNG
(US10836720, HIJ-1016)
Show SMILES NC(=N)NCCCCNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N7O6S/c21-19(22)23-10-4-5-11-24-20(31)25-13-15(18(29)30)26-17(28)16-9-6-12-27(16)34(32,33)14-7-2-1-3-8-14/h1-3,7-8,15-16H,4-6,9-13H2,(H,26,28)(H,29,30)(H4,21,22,23)(H2,24,25,31)/t15-,16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472689
PNG
(US10836720, HIJ-1094)
Show SMILES NC(=N)Nc1cccc(c1)C(=O)NCC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H29N7O7S/c25-24(26)29-16-7-4-6-15(12-16)21(33)28-14-20(32)27-13-18(23(35)36)30-22(34)19-10-5-11-31(19)39(37,38)17-8-2-1-3-9-17/h1-4,6-9,12,18-19H,5,10-11,13-14H2,(H,27,32)(H,28,33)(H,30,34)(H,35,36)(H4,25,26,29)/t18-,19-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472689
PNG
(US10836720, HIJ-1094)
Show SMILES NC(=N)Nc1cccc(c1)C(=O)NCC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H29N7O7S/c25-24(26)29-16-7-4-6-15(12-16)21(33)28-14-20(32)27-13-18(23(35)36)30-22(34)19-10-5-11-31(19)39(37,38)17-8-2-1-3-9-17/h1-4,6-9,12,18-19H,5,10-11,13-14H2,(H,27,32)(H,28,33)(H,30,34)(H,35,36)(H4,25,26,29)/t18-,19-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472679
PNG
(US10836720, HIJ-1017)
Show SMILES NC(=N)NCCCCCNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H33N7O6S/c22-20(23)24-11-5-2-6-12-25-21(32)26-14-16(19(30)31)27-18(29)17-10-7-13-28(17)35(33,34)15-8-3-1-4-9-15/h1,3-4,8-9,16-17H,2,5-7,10-14H2,(H,27,29)(H,30,31)(H4,22,23,24)(H2,25,26,32)/t16-,17-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472686
PNG
(US10836720, HIJ-1083)
Show SMILES NC(=N)NCCCCCC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H32N6O6S/c22-21(23)24-12-6-2-5-11-18(28)25-14-16(20(30)31)26-19(29)17-10-7-13-27(17)34(32,33)15-8-3-1-4-9-15/h1,3-4,8-9,16-17H,2,5-7,10-14H2,(H,25,28)(H,26,29)(H,30,31)(H4,22,23,24)/t16-,17-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472686
PNG
(US10836720, HIJ-1083)
Show SMILES NC(=N)NCCCCCC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H32N6O6S/c22-21(23)24-12-6-2-5-11-18(28)25-14-16(20(30)31)26-19(29)17-10-7-13-27(17)34(32,33)15-8-3-1-4-9-15/h1,3-4,8-9,16-17H,2,5-7,10-14H2,(H,25,28)(H,26,29)(H,30,31)(H4,22,23,24)/t16-,17-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472690
PNG
(US10836720, HIJ-1099)
Show SMILES NC(=N)Nc1cccc(c1)C(=O)NNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H28N8O7S/c24-22(25)27-15-7-4-6-14(12-15)19(32)29-30-23(36)26-13-17(21(34)35)28-20(33)18-10-5-11-31(18)39(37,38)16-8-2-1-3-9-16/h1-4,6-9,12,17-18H,5,10-11,13H2,(H,28,33)(H,29,32)(H,34,35)(H4,24,25,27)(H2,26,30,36)/t17-,18-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472687
PNG
(US10836720, HIJ-1093)
Show SMILES OC(=O)[C@H](CNC(=O)CNC(=O)c1cccc(Nc2ccccn2)c1)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H30N6O7S/c35-25(18-31-26(36)19-8-6-9-20(16-19)32-24-13-4-5-14-29-24)30-17-22(28(38)39)33-27(37)23-12-7-15-34(23)42(40,41)21-10-2-1-3-11-21/h1-6,8-11,13-14,16,22-23H,7,12,15,17-18H2,(H,29,32)(H,30,35)(H,31,36)(H,33,37)(H,38,39)/t22-,23-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472684
PNG
(US10836720, HIJ-1018)
Show SMILES NC(=N)NCCCCCCNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C22H35N7O6S/c23-21(24)25-12-6-1-2-7-13-26-22(33)27-15-17(20(31)32)28-19(30)18-11-8-14-29(18)36(34,35)16-9-4-3-5-10-16/h3-5,9-10,17-18H,1-2,6-8,11-15H2,(H,28,30)(H,31,32)(H4,23,24,25)(H2,26,27,33)/t17-,18-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472679
PNG
(US10836720, HIJ-1017)
Show SMILES NC(=N)NCCCCCNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H33N7O6S/c22-20(23)24-11-5-2-6-12-25-21(32)26-14-16(19(30)31)27-18(29)17-10-7-13-28(17)35(33,34)15-8-3-1-4-9-15/h1,3-4,8-9,16-17H,2,5-7,10-14H2,(H,27,29)(H,30,31)(H4,22,23,24)(H2,25,26,32)/t16-,17-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472687
PNG
(US10836720, HIJ-1093)
Show SMILES OC(=O)[C@H](CNC(=O)CNC(=O)c1cccc(Nc2ccccn2)c1)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H30N6O7S/c35-25(18-31-26(36)19-8-6-9-20(16-19)32-24-13-4-5-14-29-24)30-17-22(28(38)39)33-27(37)23-12-7-15-34(23)42(40,41)21-10-2-1-3-11-21/h1-6,8-11,13-14,16,22-23H,7,12,15,17-18H2,(H,29,32)(H,30,35)(H,31,36)(H,33,37)(H,38,39)/t22-,23-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472676
PNG
(US10836720, HIJ-1016)
Show SMILES NC(=N)NCCCCNC(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N7O6S/c21-19(22)23-10-4-5-11-24-20(31)25-13-15(18(29)30)26-17(28)16-9-6-12-27(16)34(32,33)14-7-2-1-3-8-14/h1-3,7-8,15-16H,4-6,9-13H2,(H,26,28)(H,29,30)(H4,21,22,23)(H2,24,25,31)/t15-,16-/m0/s1
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n/an/a 5.05E+3n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472692
PNG
(US10836720, HIJ-1204)
Show SMILES NC(=N)Nc1cccc(c1)C(=O)NCC(=O)NC[C@H](NC(=O)C1C2CCC(CC2)N1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H33N7O7S/c28-27(29)32-18-6-4-5-17(13-18)24(36)31-15-22(35)30-14-21(26(38)39)33-25(37)23-16-9-11-19(12-10-16)34(23)42(40,41)20-7-2-1-3-8-20/h1-8,13,16,19,21,23H,9-12,14-15H2,(H,30,35)(H,31,36)(H,33,37)(H,38,39)(H4,28,29,32)/t16?,19?,21-,23?/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472694
PNG
(US10836720, HIJ-1213)
Show SMILES NC(=N)NCCCCC(=O)N[C@@H](CCCCNC(=O)OCC=C)C(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C30H46N8O9S/c1-2-19-47-30(44)34-17-8-6-13-22(36-25(39)15-7-9-16-33-29(31)32)26(40)35-20-23(28(42)43)37-27(41)24-14-10-18-38(24)48(45,46)21-11-4-3-5-12-21/h2-5,11-12,22-24H,1,6-10,13-20H2,(H,34,44)(H,35,40)(H,36,39)(H,37,41)(H,42,43)(H4,31,32,33)/t22-,23-,24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472695
PNG
(US10836720, HIJ-1216)
Show SMILES NC(=N)NCCCCC(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C47H53N9O12S2/c48-46(49)50-20-7-5-13-40(59)54-35(42(60)52-26-36(45(64)65)55-43(61)37-12-8-22-56(37)70(66,67)30-9-2-1-3-10-30)11-4-6-21-51-47(69)53-27-14-17-31(34(23-27)44(62)63)41-32-18-15-28(57)24-38(32)68-39-25-29(58)16-19-33(39)41/h1-3,9-10,14-19,23-25,35-37,57H,4-8,11-13,20-22,26H2,(H,52,60)(H,54,59)(H,55,61)(H,62,63)(H,64,65)(H4,48,49,50)(H2,51,53,69)/t35-,36-,37-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472691
PNG
(US10836720, HIJ-1203)
Show SMILES OC(=O)[C@H](CNC(=O)CNC(=O)c1cccc(NC2=NCCN2C2=NCCN2)c1)NC(=O)C1C2CCC(CC2)N1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C32H39N9O7S/c42-26(19-37-28(43)21-5-4-6-22(17-21)38-32-35-15-16-40(32)31-33-13-14-34-31)36-18-25(30(45)46)39-29(44)27-20-9-11-23(12-10-20)41(27)49(47,48)24-7-2-1-3-8-24/h1-8,17,20,23,25,27H,9-16,18-19H2,(H,33,34)(H,35,38)(H,36,42)(H,37,43)(H,39,44)(H,45,46)/t20?,23?,25-,27?/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472691
PNG
(US10836720, HIJ-1203)
Show SMILES OC(=O)[C@H](CNC(=O)CNC(=O)c1cccc(NC2=NCCN2C2=NCCN2)c1)NC(=O)C1C2CCC(CC2)N1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C32H39N9O7S/c42-26(19-37-28(43)21-5-4-6-22(17-21)38-32-35-15-16-40(32)31-33-13-14-34-31)36-18-25(30(45)46)39-29(44)27-20-9-11-23(12-10-20)41(27)49(47,48)24-7-2-1-3-8-24/h1-8,17,20,23,25,27H,9-16,18-19H2,(H,33,34)(H,35,38)(H,36,42)(H,37,43)(H,39,44)(H,45,46)/t20?,23?,25-,27?/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472694
PNG
(US10836720, HIJ-1213)
Show SMILES NC(=N)NCCCCC(=O)N[C@@H](CCCCNC(=O)OCC=C)C(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C30H46N8O9S/c1-2-19-47-30(44)34-17-8-6-13-22(36-25(39)15-7-9-16-33-29(31)32)26(40)35-20-23(28(42)43)37-27(41)24-14-10-18-38(24)48(45,46)21-11-4-3-5-12-21/h2-5,11-12,22-24H,1,6-10,13-20H2,(H,34,44)(H,35,40)(H,36,39)(H,37,41)(H,42,43)(H4,31,32,33)/t22-,23-,24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
ITGAV/ITGB1


(Homo sapiens (Human))
BDBM472695
PNG
(US10836720, HIJ-1216)
Show SMILES NC(=N)NCCCCC(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)NC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C47H53N9O12S2/c48-46(49)50-20-7-5-13-40(59)54-35(42(60)52-26-36(45(64)65)55-43(61)37-12-8-22-56(37)70(66,67)30-9-2-1-3-10-30)11-4-6-21-51-47(69)53-27-14-17-31(34(23-27)44(62)63)41-32-18-15-28(57)24-38(32)68-39-25-29(58)16-19-33(39)41/h1-3,9-10,14-19,23-25,35-37,57H,4-8,11-13,20-22,26H2,(H,52,60)(H,54,59)(H,55,61)(H,62,63)(H,64,65)(H4,48,49,50)(H2,51,53,69)/t35-,36-,37-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The blockade of integrin alpha 5 beta 1 provides a novel target for the treatment of asthma. As shown in FIGS. 1A and 1B, delivery of ATN-161, a low ...


US Patent US10836720 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%