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Patent code US10836764

Compile Data Set for Download or QSAR
Found 164 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459718
PNG
(CHEMBL4213379 | US10836764, Compound 106)
Show SMILES C(c1ccccc1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H21N3/c1-2-4-14(5-3-1)12-15-8-9-20-18-17(15)7-6-16-13-19-10-11-21(16)18/h1-5,8-9,16,19H,6-7,10-13H2/t16-/m1/s1
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1.19n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472951
PNG
((R)-4-isopentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES CC(C)CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-12(2)3-4-13-7-8-18-16-15(13)6-5-14-11-17-9-10-19(14)16/h7-8,12,14,17H,3-6,9-11H2,1-2H3/t14-/m1/s1
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1.28n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472955
PNG
((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES C(C1CCCCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H27N3/c1-2-4-14(5-3-1)12-15-8-9-20-18-17(15)7-6-16-13-19-10-11-21(16)18/h8-9,14,16,19H,1-7,10-13H2/t16-/m1/s1
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1.39n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459714
PNG
(CHEMBL4204710 | US10836764, Compound 149)
Show SMILES C1CC(C1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H21N3/c1-2-11(3-1)13-6-7-17-15-14(13)5-4-12-10-16-8-9-18(12)15/h6-7,11-12,16H,1-5,8-10H2/t12-/m1/s1
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1.41n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459708
PNG
(CHEMBL4206126 | US10836764, Compound 152)
Show SMILES FC(F)(F)CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H18F3N3/c15-14(16,17)5-3-10-4-6-19-13-12(10)2-1-11-9-18-7-8-20(11)13/h4,6,11,18H,1-3,5,7-9H2/t11-/m1/s1
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1.65n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459710
PNG
(CHEMBL4212834 | US10836764, Compound 128)
Show SMILES Fc1ccc(Cc2ccnc3N4CCNC[C@H]4CCc23)cc1
Show InChI InChI=1S/C18H20FN3/c19-15-3-1-13(2-4-15)11-14-7-8-21-18-17(14)6-5-16-12-20-9-10-22(16)18/h1-4,7-8,16,20H,5-6,9-12H2/t16-/m1/s1
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1.65n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473018
PNG
((R)-4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES Brc1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C11H14BrN3/c12-10-6-14-7-11-9(10)2-1-8-5-13-3-4-15(8)11/h6-8,13H,1-5H2/t8-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459712
PNG
(CHEMBL4218374 | US10836764, Compound 173)
Show SMILES CCCc1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-2-3-11-8-16-10-14-13(11)5-4-12-9-15-6-7-17(12)14/h8,10,12,15H,2-7,9H2,1H3/t12-/m1/s1
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1.93n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472988
PNG
((R)-4-ethyl-3-propyl-6,6a,7,8,9,10-hexahydro-5H- p...)
Show SMILES CCCc1cnc2N3CCNC[C@H]3CCc2c1CC
Show InChI InChI=1S/C16H25N3/c1-3-5-12-10-18-16-15(14(12)4-2)7-6-13-11-17-8-9-19(13)16/h10,13,17H,3-9,11H2,1-2H3/t13-/m1/s1
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2.14n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459710
PNG
(CHEMBL4212834 | US10836764, Compound 128)
Show SMILES Fc1ccc(Cc2ccnc3N4CCNC[C@H]4CCc23)cc1
Show InChI InChI=1S/C18H20FN3/c19-15-3-1-13(2-4-15)11-14-7-8-21-18-17(14)6-5-16-12-20-9-10-22(16)18/h1-4,7-8,16,20H,5-6,9-12H2/t16-/m1/s1
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2.15n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459714
PNG
(CHEMBL4204710 | US10836764, Compound 149)
Show SMILES C1CC(C1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H21N3/c1-2-11(3-1)13-6-7-17-15-14(13)5-4-12-10-16-8-9-18(12)15/h6-7,11-12,16H,1-5,8-10H2/t12-/m1/s1
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2.27n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472923
PNG
((R)-4-pentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-2-3-4-5-13-8-9-18-16-15(13)7-6-14-12-17-10-11-19(14)16/h8-9,14,17H,2-7,10-12H2,1H3/t14-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472949
PNG
((R)-4-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C12H17N3/c1-9-4-5-14-12-11(9)3-2-10-8-13-6-7-15(10)12/h4-5,10,13H,2-3,6-8H2,1H3/t10-/m1/s1
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2.47n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472913
PNG
((R)-3-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCc1cnc2N3CCNC[C@H]3CCc2c1
Show InChI InChI=1S/C14H21N3/c1-2-3-11-8-12-4-5-13-10-15-6-7-17(13)14(12)16-9-11/h8-9,13,15H,2-7,10H2,1H3/t13-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472948
PNG
((R)-4-(2-fluorobenzyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Show SMILES Fc1ccccc1Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H20FN3/c19-17-4-2-1-3-14(17)11-13-7-8-21-18-16(13)6-5-15-12-20-9-10-22(15)18/h1-4,7-8,15,20H,5-6,9-12H2/t15-/m1/s1
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2.65n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473021
PNG
((R)-4-benzyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES C(c1ccccc1)c1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H21N3/c1-2-4-14(5-3-1)10-15-11-20-13-18-17(15)7-6-16-12-19-8-9-21(16)18/h1-5,11,13,16,19H,6-10,12H2/t16-/m1/s1
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2.75n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472949
PNG
((R)-4-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C12H17N3/c1-9-4-5-14-12-11(9)3-2-10-8-13-6-7-15(10)12/h4-5,10,13H,2-3,6-8H2,1H3/t10-/m1/s1
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2.95n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473013
PNG
((R)-3-chloro-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Show SMILES FC(F)(F)CCc1c(Cl)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H17ClF3N3/c15-12-8-20-13-11(10(12)3-4-14(16,17)18)2-1-9-7-19-5-6-21(9)13/h8-9,19H,1-7H2/t9-/m1/s1
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3.67n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473014
PNG
((R)-8-methyl-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Show SMILES CN1CCN2[C@H](CCc3c(CCC(F)(F)F)ccnc23)C1
Show InChI InChI=1S/C15H20F3N3/c1-20-8-9-21-12(10-20)2-3-13-11(4-6-15(16,17)18)5-7-19-14(13)21/h5,7,12H,2-4,6,8-10H2,1H3/t12-/m1/s1
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3.71n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472926
PNG
((6aR)-4-(pentan-2-yl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Show SMILES CCCC(C)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-3-4-12(2)14-7-8-18-16-15(14)6-5-13-11-17-9-10-19(13)16/h7-8,12-13,17H,3-6,9-11H2,1-2H3/t12?,13-/m1/s1
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4.45n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472996
PNG
((R,E)-4-(but-2-en-1-yl)-6,6a,7,8,9,10-hexahydro- 5...)
Show SMILES C\C=C\Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H21N3/c1-2-3-4-12-7-8-17-15-14(12)6-5-13-11-16-9-10-18(13)15/h2-3,7-8,13,16H,4-6,9-11H2,1H3/b3-2+/t13-/m1/s1
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5.01n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459716
PNG
(CHEMBL4217787 | US10836764, Compound 121)
Show SMILES CC(C)(C)Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-16(2,3)10-12-6-7-18-15-14(12)5-4-13-11-17-8-9-19(13)15/h6-7,13,17H,4-5,8-11H2,1-3H3/t13-/m1/s1
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5.20n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473007
PNG
((R)-4-phenethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES C(Cc1ccnc2N3CCNC[C@H]3CCc12)c1ccccc1
Show InChI InChI=1S/C19H23N3/c1-2-4-15(5-3-1)6-7-16-10-11-21-19-18(16)9-8-17-14-20-12-13-22(17)19/h1-5,10-11,17,20H,6-9,12-14H2/t17-/m1/s1
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5.52n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473017
PNG
((R)-3-(cyclopentylmethyl)-4-ethyl-6,6a,7,8,9,10- h...)
Show SMILES CCc1c(CC2CCCC2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C19H29N3/c1-2-17-15(11-14-5-3-4-6-14)12-21-19-18(17)8-7-16-13-20-9-10-22(16)19/h12,14,16,20H,2-11,13H2,1H3/t16-/m1/s1
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6.35n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472930
PNG
((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-2-3-11-6-7-16-14-13(11)5-4-12-10-15-8-9-17(12)14/h6-7,12,15H,2-5,8-10H2,1H3/t12-/m1/s1
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6.85n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472983
PNG
(US10836764, Compound 122 | cyclobutyl((R)-6,6a,7,8...)
Show SMILES OC(C1CCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3O/c20-15(11-2-1-3-11)13-6-7-18-16-14(13)5-4-12-10-17-8-9-19(12)16/h6-7,11-12,15,17,20H,1-5,8-10H2/t12-,15?/m1/s1
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7.42n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472921
PNG
((R)-4-(2-methoxyethyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Show SMILES COCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3O/c1-18-9-5-11-4-6-16-14-13(11)3-2-12-10-15-7-8-17(12)14/h4,6,12,15H,2-3,5,7-10H2,1H3/t12-/m1/s1
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7.76n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459709
PNG
(CHEMBL4209052 | US10836764, Compound 137)
Show SMILES C(C1CCC1)c1ccnc2N3CCNCC3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-12(3-1)10-13-6-7-18-16-15(13)5-4-14-11-17-8-9-19(14)16/h6-7,12,14,17H,1-5,8-11H2
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7.90n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472995
PNG
((R)-4-(pyridin-2-ylmethyl)-6,6a,7,8,9,10- hexahydr...)
Show SMILES C(c1ccccn1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H20N4/c1-2-7-19-14(3-1)11-13-6-8-20-17-16(13)5-4-15-12-18-9-10-21(15)17/h1-3,6-8,15,18H,4-5,9-12H2/t15-/m1/s1
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9.48n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472923
PNG
((R)-4-pentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-2-3-4-5-13-8-9-18-16-15(13)7-6-14-12-17-10-11-19(14)16/h8-9,14,17H,2-7,10-12H2,1H3/t14-/m1/s1
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9.53n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473020
PNG
((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES C(C1CCCCC1)c1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H27N3/c1-2-4-14(5-3-1)10-15-11-20-13-18-17(15)7-6-16-12-19-8-9-21(16)18/h11,13-14,16,19H,1-10,12H2/t16-/m1/s1
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9.55n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472999
PNG
((R)-4-cyclopentyl-6,6a,7,8,9,10-hexahydro-5H- pyra...)
Show SMILES C1CCC(C1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-4-12(3-1)14-7-8-18-16-15(14)6-5-13-11-17-9-10-19(13)16/h7-8,12-13,17H,1-6,9-11H2/t13-/m1/s1
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9.89n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459714
PNG
(CHEMBL4204710 | US10836764, Compound 149)
Show SMILES C1CC(C1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H21N3/c1-2-11(3-1)13-6-7-17-15-14(13)5-4-12-10-16-8-9-18(12)15/h6-7,11-12,16H,1-5,8-10H2/t12-/m1/s1
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10.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472954
PNG
((R)-4-(methoxymethyl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Show SMILES COCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C13H19N3O/c1-17-9-10-4-5-15-13-12(10)3-2-11-8-14-6-7-16(11)13/h4-5,11,14H,2-3,6-9H2,1H3/t11-/m1/s1
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10.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472929
PNG
((R)-4-butyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES CCCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3/c1-2-3-4-12-7-8-17-15-14(12)6-5-13-11-16-9-10-18(13)15/h7-8,13,16H,2-6,9-11H2,1H3/t13-/m1/s1
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10.6n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473007
PNG
((R)-4-phenethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES C(Cc1ccnc2N3CCNC[C@H]3CCc12)c1ccccc1
Show InChI InChI=1S/C19H23N3/c1-2-4-15(5-3-1)6-7-16-10-11-21-19-18(16)9-8-17-14-20-12-13-22(17)19/h1-5,10-11,17,20H,6-9,12-14H2/t17-/m1/s1
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10.8n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472930
PNG
((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-2-3-11-6-7-16-14-13(11)5-4-12-10-15-8-9-17(12)14/h6-7,12,15H,2-5,8-10H2,1H3/t12-/m1/s1
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10.8n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473015
PNG
((R)-4-chloro-2-(methylthio)-6,6a,7,8,9,10- hexahyd...)
Show SMILES CSc1nc(Cl)c2CC[C@@H]3CNCCN3c2n1
Show InChI InChI=1S/C11H15ClN4S/c1-17-11-14-9(12)8-3-2-7-6-13-4-5-16(7)10(8)15-11/h7,13H,2-6H2,1H3/t7-/m1/s1
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11.2n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472989
PNG
((R)-3-benzyl-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- p...)
Show SMILES CCc1c(Cc2ccccc2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C20H25N3/c1-2-18-16(12-15-6-4-3-5-7-15)13-22-20-19(18)9-8-17-14-21-10-11-23(17)20/h3-7,13,17,21H,2,8-12,14H2,1H3/t17-/m1/s1
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11.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473016
PNG
((R)-4-(cyclopentylmethyl)-6,6a,7,8,9,10- hexahydro...)
Show SMILES C(C1CCCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H25N3/c1-2-4-13(3-1)11-14-7-8-19-17-16(14)6-5-15-12-18-9-10-20(15)17/h7-8,13,15,18H,1-6,9-12H2/t15-/m1/s1
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11.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472928
PNG
((R)-4-isopropyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES CC(C)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-10(2)12-5-6-16-14-13(12)4-3-11-9-15-7-8-17(11)14/h5-6,10-11,15H,3-4,7-9H2,1-2H3/t11-/m1/s1
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12.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473018
PNG
((R)-4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES Brc1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C11H14BrN3/c12-10-6-14-7-11-9(10)2-1-8-5-13-3-4-15(8)11/h6-8,13H,1-5H2/t8-/m1/s1
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13n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472997
PNG
((R)-4-(isopropoxymethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES CC(C)OCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3O/c1-11(2)19-10-12-5-6-17-15-14(12)4-3-13-9-16-7-8-18(13)15/h5-6,11,13,16H,3-4,7-10H2,1-2H3/t13-/m1/s1
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13.8n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459713
PNG
(CHEMBL4213447 | US10836764, Compound 176)
Show SMILES C(C1CCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-12(3-1)10-13-6-7-18-16-15(13)5-4-14-11-17-8-9-19(14)16/h6-7,12,14,17H,1-5,8-11H2/t14-/m1/s1
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14.1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472929
PNG
((R)-4-butyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES CCCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3/c1-2-3-4-12-7-8-17-15-14(12)6-5-13-11-16-9-10-18(13)15/h7-8,13,16H,2-6,9-11H2,1H3/t13-/m1/s1
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14.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472927
PNG
((R)-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C13H19N3/c1-2-10-5-6-15-13-12(10)4-3-11-9-14-7-8-16(11)13/h5-6,11,14H,2-4,7-9H2,1H3/t11-/m1/s1
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16.1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472990
PNG
((6aR)-4-((tetrahydro-2H-pyran-2-yl)methyl)- 6,6a,7...)
Show SMILES C(C1CCCCO1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H25N3O/c1-2-10-21-15(3-1)11-13-6-7-19-17-16(13)5-4-14-12-18-8-9-20(14)17/h6-7,14-15,18H,1-5,8-12H2/t14-,15?/m1/s1
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16.1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472996
PNG
((R,E)-4-(but-2-en-1-yl)-6,6a,7,8,9,10-hexahydro- 5...)
Show SMILES C\C=C\Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H21N3/c1-2-3-4-12-7-8-17-15-14(12)6-5-13-11-16-9-10-18(13)15/h2-3,7-8,13,16H,4-6,9-11H2,1H3/b3-2+/t13-/m1/s1
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16.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459707
PNG
(CHEMBL4208452 | US10836764, Compound 115)
Show SMILES Fc1cccc(Cc2ccnc3N4CCNC[C@H]4CCc23)c1
Show InChI InChI=1S/C18H20FN3/c19-15-3-1-2-13(11-15)10-14-6-7-21-18-17(14)5-4-16-12-20-8-9-22(16)18/h1-3,6-7,11,16,20H,4-5,8-10,12H2/t16-/m1/s1
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16.7n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472927
PNG
((R)-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C13H19N3/c1-2-10-5-6-15-13-12(10)4-3-11-9-14-7-8-16(11)13/h5-6,11,14H,2-4,7-9H2,1H3/t11-/m1/s1
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19.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473010
PNG
((R)-3-(cyclohexylmethyl)-4-ethyl-6,6a,7,8,9,10- he...)
Show SMILES CCc1c(CC2CCCCC2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C20H31N3/c1-2-18-16(12-15-6-4-3-5-7-15)13-22-20-19(18)9-8-17-14-21-10-11-23(17)20/h13,15,17,21H,2-12,14H2,1H3/t17-/m1/s1
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21.1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472913
PNG
((R)-3-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCc1cnc2N3CCNC[C@H]3CCc2c1
Show InChI InChI=1S/C14H21N3/c1-2-3-11-8-12-4-5-13-10-15-6-7-17(13)14(12)16-9-11/h8-9,13,15H,2-7,10H2,1H3/t13-/m1/s1
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22.1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472984
PNG
((R)-4-(thiophen-2-yl)-6,6a,7,8,9,10-hexahydro-5H- ...)
Show SMILES C1CN2[C@H](CCc3c2nccc3-c2cccs2)CN1
Show InChI InChI=1S/C15H17N3S/c1-2-14(19-9-1)12-5-6-17-15-13(12)4-3-11-10-16-7-8-18(11)15/h1-2,5-6,9,11,16H,3-4,7-8,10H2/t11-/m1/s1
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22.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473016
PNG
((R)-4-(cyclopentylmethyl)-6,6a,7,8,9,10- hexahydro...)
Show SMILES C(C1CCCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H25N3/c1-2-4-13(3-1)11-14-7-8-19-17-16(14)6-5-15-12-18-9-10-20(15)17/h7-8,13,15,18H,1-6,9-12H2/t15-/m1/s1
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23.8n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472988
PNG
((R)-4-ethyl-3-propyl-6,6a,7,8,9,10-hexahydro-5H- p...)
Show SMILES CCCc1cnc2N3CCNC[C@H]3CCc2c1CC
Show InChI InChI=1S/C16H25N3/c1-3-5-12-10-18-16-15(14(12)4-2)7-6-13-11-17-8-9-19(13)16/h10,13,17H,3-9,11H2,1-2H3/t13-/m1/s1
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24.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459718
PNG
(CHEMBL4213379 | US10836764, Compound 106)
Show SMILES C(c1ccccc1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H21N3/c1-2-4-14(5-3-1)12-15-8-9-20-18-17(15)7-6-16-13-19-10-11-21(16)18/h1-5,8-9,16,19H,6-7,10-13H2/t16-/m1/s1
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25.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472926
PNG
((6aR)-4-(pentan-2-yl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Show SMILES CCCC(C)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-3-4-12(2)14-7-8-18-16-15(14)6-5-13-11-17-9-10-19(13)16/h7-8,12-13,17H,3-6,9-11H2,1-2H3/t12?,13-/m1/s1
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25.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472931
PNG
((R)-4-isobutyl-6,6a,7,8,9,10-hexahydro-5H- pyrazin...)
Show SMILES CC(C)Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3/c1-11(2)9-12-5-6-17-15-14(12)4-3-13-10-16-7-8-18(13)15/h5-6,11,13,16H,3-4,7-10H2,1-2H3/t13-/m1/s1
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28.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472951
PNG
((R)-4-isopentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES CC(C)CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-12(2)3-4-13-7-8-18-16-15(13)6-5-14-11-17-9-10-19(14)16/h7-8,12,14,17H,3-6,9-11H2,1-2H3/t14-/m1/s1
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28.8n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472999
PNG
((R)-4-cyclopentyl-6,6a,7,8,9,10-hexahydro-5H- pyra...)
Show SMILES C1CCC(C1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-4-12(3-1)14-7-8-18-16-15(14)6-5-13-11-17-9-10-19(13)16/h7-8,12-13,17H,1-6,9-11H2/t13-/m1/s1
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29.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473009
PNG
((R)-4-ethyl-3-(isopropoxymethyl)-6,6a,7,8,9,10- he...)
Show SMILES CCc1c(COC(C)C)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H27N3O/c1-4-15-13(11-21-12(2)3)9-19-17-16(15)6-5-14-10-18-7-8-20(14)17/h9,12,14,18H,4-8,10-11H2,1-3H3/t14-/m1/s1
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29.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473007
PNG
((R)-4-phenethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES C(Cc1ccnc2N3CCNC[C@H]3CCc12)c1ccccc1
Show InChI InChI=1S/C19H23N3/c1-2-4-15(5-3-1)6-7-16-10-11-21-19-18(16)9-8-17-14-20-12-13-22(17)19/h1-5,10-11,17,20H,6-9,12-14H2/t17-/m1/s1
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29.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472951
PNG
((R)-4-isopentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES CC(C)CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-12(2)3-4-13-7-8-18-16-15(13)6-5-14-11-17-9-10-19(14)16/h7-8,12,14,17H,3-6,9-11H2,1-2H3/t14-/m1/s1
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29.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472928
PNG
((R)-4-isopropyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES CC(C)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-10(2)12-5-6-16-14-13(12)4-3-11-9-15-7-8-17(11)14/h5-6,10-11,15H,3-4,7-9H2,1-2H3/t11-/m1/s1
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32.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472931
PNG
((R)-4-isobutyl-6,6a,7,8,9,10-hexahydro-5H- pyrazin...)
Show SMILES CC(C)Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3/c1-11(2)9-12-5-6-17-15-14(12)4-3-13-10-16-7-8-18(13)15/h5-6,11,13,16H,3-4,7-10H2,1-2H3/t13-/m1/s1
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33n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473013
PNG
((R)-3-chloro-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Show SMILES FC(F)(F)CCc1c(Cl)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H17ClF3N3/c15-12-8-20-13-11(10(12)3-4-14(16,17)18)2-1-9-7-19-5-6-21(9)13/h8-9,19H,1-7H2/t9-/m1/s1
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34.1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472913
PNG
((R)-3-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCc1cnc2N3CCNC[C@H]3CCc2c1
Show InChI InChI=1S/C14H21N3/c1-2-3-11-8-12-4-5-13-10-15-6-7-17(13)14(12)16-9-11/h8-9,13,15H,2-7,10H2,1H3/t13-/m1/s1
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35.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472948
PNG
((R)-4-(2-fluorobenzyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Show SMILES Fc1ccccc1Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H20FN3/c19-17-4-2-1-3-14(17)11-13-7-8-21-18-16(13)6-5-15-12-20-9-10-22(15)18/h1-4,7-8,15,20H,5-6,9-12H2/t15-/m1/s1
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35.6n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459713
PNG
(CHEMBL4213447 | US10836764, Compound 176)
Show SMILES C(C1CCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-12(3-1)10-13-6-7-18-16-15(13)5-4-14-11-17-8-9-19(14)16/h6-7,12,14,17H,1-5,8-11H2/t14-/m1/s1
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36.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472989
PNG
((R)-3-benzyl-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- p...)
Show SMILES CCc1c(Cc2ccccc2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C20H25N3/c1-2-18-16(12-15-6-4-3-5-7-15)13-22-20-19(18)9-8-17-14-21-10-11-23(17)20/h3-7,13,17,21H,2,8-12,14H2,1H3/t17-/m1/s1
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36.7n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473015
PNG
((R)-4-chloro-2-(methylthio)-6,6a,7,8,9,10- hexahyd...)
Show SMILES CSc1nc(Cl)c2CC[C@@H]3CNCCN3c2n1
Show InChI InChI=1S/C11H15ClN4S/c1-17-11-14-9(12)8-3-2-7-6-13-4-5-16(7)10(8)15-11/h7,13H,2-6H2,1H3/t7-/m1/s1
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36.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472926
PNG
((6aR)-4-(pentan-2-yl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Show SMILES CCCC(C)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-3-4-12(2)14-7-8-18-16-15(14)6-5-13-11-17-9-10-19(13)16/h7-8,12-13,17H,3-6,9-11H2,1-2H3/t12?,13-/m1/s1
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37.7n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473013
PNG
((R)-3-chloro-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Show SMILES FC(F)(F)CCc1c(Cl)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H17ClF3N3/c15-12-8-20-13-11(10(12)3-4-14(16,17)18)2-1-9-7-19-5-6-21(9)13/h8-9,19H,1-7H2/t9-/m1/s1
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39.7n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472999
PNG
((R)-4-cyclopentyl-6,6a,7,8,9,10-hexahydro-5H- pyra...)
Show SMILES C1CCC(C1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-4-12(3-1)14-7-8-18-16-15(14)6-5-13-11-17-9-10-19(13)16/h7-8,12-13,17H,1-6,9-11H2/t13-/m1/s1
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41.2n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472955
PNG
((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES C(C1CCCCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H27N3/c1-2-4-14(5-3-1)12-15-8-9-20-18-17(15)7-6-16-13-19-10-11-21(16)18/h8-9,14,16,19H,1-7,10-13H2/t16-/m1/s1
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43.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459712
PNG
(CHEMBL4218374 | US10836764, Compound 173)
Show SMILES CCCc1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-2-3-11-8-16-10-14-13(11)5-4-12-9-15-6-7-17(12)14/h8,10,12,15H,2-7,9H2,1H3/t12-/m1/s1
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44n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472949
PNG
((R)-4-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C12H17N3/c1-9-4-5-14-12-11(9)3-2-10-8-13-6-7-15(10)12/h4-5,10,13H,2-3,6-8H2,1H3/t10-/m1/s1
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44.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473003
PNG
((R)-4-(3,3,3-trifluoropropyl)-5,6,6a,7,8,9,10,11- ...)
Show SMILES FC(F)(F)CCc1ccnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C15H20F3N3/c16-15(17,18)6-4-11-5-8-20-14-13(11)3-2-12-10-19-7-1-9-21(12)14/h5,8,12,19H,1-4,6-7,9-10H2/t12-/m1/s1
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46n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473009
PNG
((R)-4-ethyl-3-(isopropoxymethyl)-6,6a,7,8,9,10- he...)
Show SMILES CCc1c(COC(C)C)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H27N3O/c1-4-15-13(11-21-12(2)3)9-19-17-16(15)6-5-14-10-18-7-8-20(14)17/h9,12,14,18H,4-8,10-11H2,1-3H3/t14-/m1/s1
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47.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459708
PNG
(CHEMBL4206126 | US10836764, Compound 152)
Show SMILES FC(F)(F)CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H18F3N3/c15-14(16,17)5-3-10-4-6-19-13-12(10)2-1-11-9-18-7-8-20(11)13/h4,6,11,18H,1-3,5,7-9H2/t11-/m1/s1
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47.6n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473012
PNG
((R)-3-cyclobutyl-4-ethyl-6,6a,7,8,9,10-hexahydro- ...)
Show SMILES CCc1c(cnc2N3CCNC[C@H]3CCc12)C1CCC1
Show InChI InChI=1S/C17H25N3/c1-2-14-15-7-6-13-10-18-8-9-20(13)17(15)19-11-16(14)12-4-3-5-12/h11-13,18H,2-10H2,1H3/t13-/m1/s1
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47.7n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459710
PNG
(CHEMBL4212834 | US10836764, Compound 128)
Show SMILES Fc1ccc(Cc2ccnc3N4CCNC[C@H]4CCc23)cc1
Show InChI InChI=1S/C18H20FN3/c19-15-3-1-13(2-4-15)11-14-7-8-21-18-17(14)6-5-16-12-20-9-10-22(16)18/h1-4,7-8,16,20H,5-6,9-12H2/t16-/m1/s1
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49n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472989
PNG
((R)-3-benzyl-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- p...)
Show SMILES CCc1c(Cc2ccccc2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C20H25N3/c1-2-18-16(12-15-6-4-3-5-7-15)13-22-20-19(18)9-8-17-14-21-10-11-23(17)20/h3-7,13,17,21H,2,8-12,14H2,1H3/t17-/m1/s1
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49.2n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473017
PNG
((R)-3-(cyclopentylmethyl)-4-ethyl-6,6a,7,8,9,10- h...)
Show SMILES CCc1c(CC2CCCC2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C19H29N3/c1-2-17-15(11-14-5-3-4-6-14)12-21-19-18(17)8-7-16-13-20-9-10-22(16)19/h12,14,16,20H,2-11,13H2,1H3/t16-/m1/s1
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52n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473004
PNG
(5-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1,2-...)
Show SMILES CC1CC2CNCCN2c2ncccc12
Show InChI InChI=1S/C12H17N3/c1-9-7-10-8-13-5-6-15(10)12-11(9)3-2-4-14-12/h2-4,9-10,13H,5-8H2,1H3
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52.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473002
PNG
((R)-4-bromo-5,6,6a,7,8,9,10,11-octahydro- [1,4]dia...)
Show SMILES Brc1ccnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C12H16BrN3/c13-11-4-6-15-12-10(11)3-2-9-8-14-5-1-7-16(9)12/h4,6,9,14H,1-3,5,7-8H2/t9-/m1/s1
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55.2n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473014
PNG
((R)-8-methyl-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Show SMILES CN1CCN2[C@H](CCc3c(CCC(F)(F)F)ccnc23)C1
Show InChI InChI=1S/C15H20F3N3/c1-20-8-9-21-12(10-20)2-3-13-11(4-6-15(16,17)18)5-7-19-14(13)21/h5,7,12H,2-4,6,8-10H2,1H3/t12-/m1/s1
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58n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472955
PNG
((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES C(C1CCCCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H27N3/c1-2-4-14(5-3-1)12-15-8-9-20-18-17(15)7-6-16-13-19-10-11-21(16)18/h8-9,14,16,19H,1-7,10-13H2/t16-/m1/s1
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58.7n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472983
PNG
(US10836764, Compound 122 | cyclobutyl((R)-6,6a,7,8...)
Show SMILES OC(C1CCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3O/c20-15(11-2-1-3-11)13-6-7-18-16-14(13)5-4-12-10-17-8-9-19(12)16/h6-7,11-12,15,17,20H,1-5,8-10H2/t12-,15?/m1/s1
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58.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459716
PNG
(CHEMBL4217787 | US10836764, Compound 121)
Show SMILES CC(C)(C)Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-16(2,3)10-12-6-7-18-15-14(12)5-4-13-11-17-8-9-19(13)15/h6-7,13,17H,4-5,8-11H2,1-3H3/t13-/m1/s1
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60.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472994
PNG
((R)-3-(6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2- a]...)
Show SMILES N#CCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H18N4/c15-6-1-2-11-5-7-17-14-13(11)4-3-12-10-16-8-9-18(12)14/h5,7,12,16H,1-4,8-10H2/t12-/m1/s1
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64.8n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473011
PNG
((6aR)-4-ethyl-3-((tetrahydro-2H-pyran-2- yl)methyl...)
Show SMILES CCc1c(CC2CCCCO2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C19H29N3O/c1-2-17-14(11-16-5-3-4-10-23-16)12-21-19-18(17)7-6-15-13-20-8-9-22(15)19/h12,15-16,20H,2-11,13H2,1H3/t15-,16?/m1/s1
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65.2n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473004
PNG
(5-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1,2-...)
Show SMILES CC1CC2CNCCN2c2ncccc12
Show InChI InChI=1S/C12H17N3/c1-9-7-10-8-13-5-6-15(10)12-11(9)3-2-4-14-12/h2-4,9-10,13H,5-8H2,1H3
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66.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472995
PNG
((R)-4-(pyridin-2-ylmethyl)-6,6a,7,8,9,10- hexahydr...)
Show SMILES C(c1ccccn1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H20N4/c1-2-7-19-14(3-1)11-13-6-8-20-17-16(13)5-4-15-12-18-9-10-21(15)17/h1-3,6-8,15,18H,4-5,9-12H2/t15-/m1/s1
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66.9n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472984
PNG
((R)-4-(thiophen-2-yl)-6,6a,7,8,9,10-hexahydro-5H- ...)
Show SMILES C1CN2[C@H](CCc3c2nccc3-c2cccs2)CN1
Show InChI InChI=1S/C15H17N3S/c1-2-14(19-9-1)12-5-6-17-15-13(12)4-3-11-10-16-7-8-18(11)15/h1-2,5-6,9,11,16H,3-4,7-8,10H2/t11-/m1/s1
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68.8n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473008
PNG
((R)-3-(4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazin...)
Show SMILES CCc1c(CCC#N)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H22N4/c1-2-14-12(4-3-7-17)10-19-16-15(14)6-5-13-11-18-8-9-20(13)16/h10,13,18H,2-6,8-9,11H2,1H3/t13-/m1/s1
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71.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473018
PNG
((R)-4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES Brc1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C11H14BrN3/c12-10-6-14-7-11-9(10)2-1-8-5-13-3-4-15(8)11/h6-8,13H,1-5H2/t8-/m1/s1
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72.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473012
PNG
((R)-3-cyclobutyl-4-ethyl-6,6a,7,8,9,10-hexahydro- ...)
Show SMILES CCc1c(cnc2N3CCNC[C@H]3CCc12)C1CCC1
Show InChI InChI=1S/C17H25N3/c1-2-14-15-7-6-13-10-18-8-9-20(13)17(15)19-11-16(14)12-4-3-5-12/h11-13,18H,2-10H2,1H3/t13-/m1/s1
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90.4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472983
PNG
(US10836764, Compound 122 | cyclobutyl((R)-6,6a,7,8...)
Show SMILES OC(C1CCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3O/c20-15(11-2-1-3-11)13-6-7-18-16-14(13)5-4-12-10-17-8-9-19(12)16/h6-7,11-12,15,17,20H,1-5,8-10H2/t12-,15?/m1/s1
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97.3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472921
PNG
((R)-4-(2-methoxyethyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Show SMILES COCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3O/c1-18-9-5-11-4-6-16-14-13(11)3-2-12-10-15-7-8-17(12)14/h4,6,12,15H,2-3,5,7-10H2,1H3/t12-/m1/s1
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99.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472954
PNG
((R)-4-(methoxymethyl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Show SMILES COCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C13H19N3O/c1-17-9-10-4-5-15-13-12(10)3-2-11-8-14-6-7-16(11)13/h4-5,11,14H,2-3,6-9H2,1H3/t11-/m1/s1
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106n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473020
PNG
((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES C(C1CCCCC1)c1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H27N3/c1-2-4-14(5-3-1)10-15-11-20-13-18-17(15)7-6-16-12-19-8-9-21(16)18/h11,13-14,16,19H,1-10,12H2/t16-/m1/s1
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107n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459716
PNG
(CHEMBL4217787 | US10836764, Compound 121)
Show SMILES CC(C)(C)Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-16(2,3)10-12-6-7-18-15-14(12)5-4-13-11-17-8-9-19(13)15/h6-7,13,17H,4-5,8-11H2,1-3H3/t13-/m1/s1
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118n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472984
PNG
((R)-4-(thiophen-2-yl)-6,6a,7,8,9,10-hexahydro-5H- ...)
Show SMILES C1CN2[C@H](CCc3c2nccc3-c2cccs2)CN1
Show InChI InChI=1S/C15H17N3S/c1-2-14(19-9-1)12-5-6-17-15-13(12)4-3-11-10-16-7-8-18(11)15/h1-2,5-6,9,11,16H,3-4,7-8,10H2/t11-/m1/s1
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122n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459712
PNG
(CHEMBL4218374 | US10836764, Compound 173)
Show SMILES CCCc1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-2-3-11-8-16-10-14-13(11)5-4-12-9-15-6-7-17(12)14/h8,10,12,15H,2-7,9H2,1H3/t12-/m1/s1
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126n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473002
PNG
((R)-4-bromo-5,6,6a,7,8,9,10,11-octahydro- [1,4]dia...)
Show SMILES Brc1ccnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C12H16BrN3/c13-11-4-6-15-12-10(11)3-2-9-8-14-5-1-7-16(9)12/h4,6,9,14H,1-3,5,7-8H2/t9-/m1/s1
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127n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473015
PNG
((R)-4-chloro-2-(methylthio)-6,6a,7,8,9,10- hexahyd...)
Show SMILES CSc1nc(Cl)c2CC[C@@H]3CNCCN3c2n1
Show InChI InChI=1S/C11H15ClN4S/c1-17-11-14-9(12)8-3-2-7-6-13-4-5-16(7)10(8)15-11/h7,13H,2-6H2,1H3/t7-/m1/s1
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129n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459709
PNG
(CHEMBL4209052 | US10836764, Compound 137)
Show SMILES C(C1CCC1)c1ccnc2N3CCNCC3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-12(3-1)10-13-6-7-18-16-15(13)5-4-14-11-17-8-9-19(14)16/h6-7,12,14,17H,1-5,8-11H2
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134n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472954
PNG
((R)-4-(methoxymethyl)-6,6a,7,8,9,10-hexahydro- 5H-...)
Show SMILES COCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C13H19N3O/c1-17-9-10-4-5-15-13-12(10)3-2-11-8-14-6-7-16(11)13/h4-5,11,14H,2-3,6-9H2,1H3/t11-/m1/s1
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138n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473020
PNG
((R)-4-(cyclohexylmethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES C(C1CCCCC1)c1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H27N3/c1-2-4-14(5-3-1)10-15-11-20-13-18-17(15)7-6-16-12-19-8-9-21(16)18/h11,13-14,16,19H,1-10,12H2/t16-/m1/s1
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140n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472930
PNG
((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-2-3-11-6-7-16-14-13(11)5-4-12-10-15-8-9-17(12)14/h6-7,12,15H,2-5,8-10H2,1H3/t12-/m1/s1
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162n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472921
PNG
((R)-4-(2-methoxyethyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Show SMILES COCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3O/c1-18-9-5-11-4-6-16-14-13(11)3-2-12-10-15-7-8-17(12)14/h4,6,12,15H,2-3,5,7-10H2,1H3/t12-/m1/s1
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177n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459707
PNG
(CHEMBL4208452 | US10836764, Compound 115)
Show SMILES Fc1cccc(Cc2ccnc3N4CCNC[C@H]4CCc23)c1
Show InChI InChI=1S/C18H20FN3/c19-15-3-1-2-13(11-15)10-14-6-7-21-18-17(14)5-4-16-12-20-8-9-22(16)18/h1-3,6-7,11,16,20H,4-5,8-10,12H2/t16-/m1/s1
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195n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472997
PNG
((R)-4-(isopropoxymethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES CC(C)OCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3O/c1-11(2)19-10-12-5-6-17-15-14(12)4-3-13-9-16-7-8-18(13)15/h5-6,11,13,16H,3-4,7-10H2,1-2H3/t13-/m1/s1
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209n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459708
PNG
(CHEMBL4206126 | US10836764, Compound 152)
Show SMILES FC(F)(F)CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H18F3N3/c15-14(16,17)5-3-10-4-6-19-13-12(10)2-1-11-9-18-7-8-20(11)13/h4,6,11,18H,1-3,5,7-9H2/t11-/m1/s1
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210n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472990
PNG
((6aR)-4-((tetrahydro-2H-pyran-2-yl)methyl)- 6,6a,7...)
Show SMILES C(C1CCCCO1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H25N3O/c1-2-10-21-15(3-1)11-13-6-7-19-17-16(13)5-4-14-12-18-8-9-20(14)17/h6-7,14-15,18H,1-5,8-12H2/t14-,15?/m1/s1
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212n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472997
PNG
((R)-4-(isopropoxymethyl)-6,6a,7,8,9,10- hexahydro-...)
Show SMILES CC(C)OCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3O/c1-11(2)19-10-12-5-6-17-15-14(12)4-3-13-9-16-7-8-18(13)15/h5-6,11,13,16H,3-4,7-10H2,1-2H3/t13-/m1/s1
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222n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473010
PNG
((R)-3-(cyclohexylmethyl)-4-ethyl-6,6a,7,8,9,10- he...)
Show SMILES CCc1c(CC2CCCCC2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C20H31N3/c1-2-18-16(12-15-6-4-3-5-7-15)13-22-20-19(18)9-8-17-14-21-10-11-23(17)20/h13,15,17,21H,2-12,14H2,1H3/t17-/m1/s1
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233n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473008
PNG
((R)-3-(4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazin...)
Show SMILES CCc1c(CCC#N)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H22N4/c1-2-14-12(4-3-7-17)10-19-16-15(14)6-5-13-11-18-8-9-20(13)16/h10,13,18H,2-6,8-9,11H2,1H3/t13-/m1/s1
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251n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473021
PNG
((R)-4-benzyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES C(c1ccccc1)c1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H21N3/c1-2-4-14(5-3-1)10-15-11-20-13-18-17(15)7-6-16-12-19-8-9-21(16)18/h1-5,11,13,16,19H,6-10,12H2/t16-/m1/s1
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270n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473005
PNG
((R)-4-chloro-2-(methylthio)-5,6,6a,7,8,9,10,11- oc...)
Show SMILES CSc1nc(Cl)c2CC[C@@H]3CNCCCN3c2n1
Show InChI InChI=1S/C12H17ClN4S/c1-18-12-15-10(13)9-4-3-8-7-14-5-2-6-17(8)11(9)16-12/h8,14H,2-7H2,1H3/t8-/m1/s1
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272n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459718
PNG
(CHEMBL4213379 | US10836764, Compound 106)
Show SMILES C(c1ccccc1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H21N3/c1-2-4-14(5-3-1)12-15-8-9-20-18-17(15)7-6-16-13-19-10-11-21(16)18/h1-5,8-9,16,19H,6-7,10-13H2/t16-/m1/s1
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277n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472948
PNG
((R)-4-(2-fluorobenzyl)-6,6a,7,8,9,10-hexahydro- 5H...)
Show SMILES Fc1ccccc1Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H20FN3/c19-17-4-2-1-3-14(17)11-13-7-8-21-18-16(13)6-5-15-12-20-9-10-22(15)18/h1-4,7-8,15,20H,5-6,9-12H2/t15-/m1/s1
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304n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50459709
PNG
(CHEMBL4209052 | US10836764, Compound 137)
Show SMILES C(C1CCC1)c1ccnc2N3CCNCC3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-12(3-1)10-13-6-7-18-16-15(13)5-4-14-11-17-8-9-19(14)16/h6-7,12,14,17H,1-5,8-11H2
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311n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473014
PNG
((R)-8-methyl-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9...)
Show SMILES CN1CCN2[C@H](CCc3c(CCC(F)(F)F)ccnc23)C1
Show InChI InChI=1S/C15H20F3N3/c1-20-8-9-21-12(10-20)2-3-13-11(4-6-15(16,17)18)5-7-19-14(13)21/h5,7,12H,2-4,6,8-10H2,1H3/t12-/m1/s1
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331n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473017
PNG
((R)-3-(cyclopentylmethyl)-4-ethyl-6,6a,7,8,9,10- h...)
Show SMILES CCc1c(CC2CCCC2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C19H29N3/c1-2-17-15(11-14-5-3-4-6-14)12-21-19-18(17)8-7-16-13-20-9-10-22(16)19/h12,14,16,20H,2-11,13H2,1H3/t16-/m1/s1
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351n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472992
PNG
(4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1,2-a...)
Show SMILES Brc1ccnc2N3CCNCC3CCc12
Show InChI InChI=1S/C11H14BrN3/c12-10-3-4-14-11-9(10)2-1-8-7-13-5-6-15(8)11/h3-4,8,13H,1-2,5-7H2
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365n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472995
PNG
((R)-4-(pyridin-2-ylmethyl)-6,6a,7,8,9,10- hexahydr...)
Show SMILES C(c1ccccn1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H20N4/c1-2-7-19-14(3-1)11-13-6-8-20-17-16(13)5-4-15-12-18-9-10-21(15)17/h1-3,6-8,15,18H,4-5,9-12H2/t15-/m1/s1
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376n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472923
PNG
((R)-4-pentyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES CCCCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H25N3/c1-2-3-4-5-13-8-9-18-16-15(13)7-6-14-12-17-10-11-19(14)16/h8-9,14,17H,2-7,10-12H2,1H3/t14-/m1/s1
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401n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473009
PNG
((R)-4-ethyl-3-(isopropoxymethyl)-6,6a,7,8,9,10- he...)
Show SMILES CCc1c(COC(C)C)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H27N3O/c1-4-15-13(11-21-12(2)3)9-19-17-16(15)6-5-14-10-18-7-8-20(14)17/h9,12,14,18H,4-8,10-11H2,1-3H3/t14-/m1/s1
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468n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472929
PNG
((R)-4-butyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES CCCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3/c1-2-3-4-12-7-8-17-15-14(12)6-5-13-11-16-9-10-18(13)15/h7-8,13,16H,2-6,9-11H2,1H3/t13-/m1/s1
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500n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50459707
PNG
(CHEMBL4208452 | US10836764, Compound 115)
Show SMILES Fc1cccc(Cc2ccnc3N4CCNC[C@H]4CCc23)c1
Show InChI InChI=1S/C18H20FN3/c19-15-3-1-2-13(11-15)10-14-6-7-21-18-17(14)5-4-16-12-20-8-9-22(16)18/h1-3,6-7,11,16,20H,4-5,8-10,12H2/t16-/m1/s1
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506n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473021
PNG
((R)-4-benzyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...)
Show SMILES C(c1ccccc1)c1cncc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C18H21N3/c1-2-4-14(5-3-1)10-15-11-20-13-18-17(15)7-6-16-12-19-8-9-21(16)18/h1-5,11,13,16,19H,6-10,12H2/t16-/m1/s1
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520n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50459713
PNG
(CHEMBL4213447 | US10836764, Compound 176)
Show SMILES C(C1CCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H23N3/c1-2-12(3-1)10-13-6-7-18-16-15(13)5-4-14-11-17-8-9-19(14)16/h6-7,12,14,17H,1-5,8-11H2/t14-/m1/s1
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523n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472996
PNG
((R,E)-4-(but-2-en-1-yl)-6,6a,7,8,9,10-hexahydro- 5...)
Show SMILES C\C=C\Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H21N3/c1-2-3-4-12-7-8-17-15-14(12)6-5-13-11-16-9-10-18(13)15/h2-3,7-8,13,16H,4-6,9-11H2,1H3/b3-2+/t13-/m1/s1
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548n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472927
PNG
((R)-4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1...)
Show SMILES CCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C13H19N3/c1-2-10-5-6-15-13-12(10)4-3-11-9-14-7-8-16(11)13/h5-6,11,14H,2-4,7-9H2,1H3/t11-/m1/s1
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562n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473011
PNG
((6aR)-4-ethyl-3-((tetrahydro-2H-pyran-2- yl)methyl...)
Show SMILES CCc1c(CC2CCCCO2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C19H29N3O/c1-2-17-14(11-16-5-3-4-10-23-16)12-21-19-18(17)7-6-15-13-20-8-9-22(15)19/h12,15-16,20H,2-11,13H2,1H3/t15-,16?/m1/s1
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570n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472931
PNG
((R)-4-isobutyl-6,6a,7,8,9,10-hexahydro-5H- pyrazin...)
Show SMILES CC(C)Cc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C15H23N3/c1-11(2)9-12-5-6-17-15-14(12)4-3-13-10-16-7-8-18(13)15/h5-6,11,13,16H,3-4,7-10H2,1-2H3/t13-/m1/s1
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587n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472994
PNG
((R)-3-(6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2- a]...)
Show SMILES N#CCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H18N4/c15-6-1-2-11-5-7-17-14-13(11)4-3-12-10-16-8-9-18(12)14/h5,7,12,16H,1-4,8-10H2/t12-/m1/s1
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665n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473010
PNG
((R)-3-(cyclohexylmethyl)-4-ethyl-6,6a,7,8,9,10- he...)
Show SMILES CCc1c(CC2CCCCC2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C20H31N3/c1-2-18-16(12-15-6-4-3-5-7-15)13-22-20-19(18)9-8-17-14-21-10-11-23(17)20/h13,15,17,21H,2-12,14H2,1H3/t17-/m1/s1
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703n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473003
PNG
((R)-4-(3,3,3-trifluoropropyl)-5,6,6a,7,8,9,10,11- ...)
Show SMILES FC(F)(F)CCc1ccnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C15H20F3N3/c16-15(17,18)6-4-11-5-8-20-14-13(11)3-2-12-10-19-7-1-9-21(12)14/h5,8,12,19H,1-4,6-7,9-10H2/t12-/m1/s1
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721n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473016
PNG
((R)-4-(cyclopentylmethyl)-6,6a,7,8,9,10- hexahydro...)
Show SMILES C(C1CCCC1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H25N3/c1-2-4-13(3-1)11-14-7-8-19-17-16(14)6-5-15-12-18-9-10-20(15)17/h7-8,13,15,18H,1-6,9-12H2/t15-/m1/s1
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790n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472994
PNG
((R)-3-(6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2- a]...)
Show SMILES N#CCCc1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H18N4/c15-6-1-2-11-5-7-17-14-13(11)4-3-12-10-16-8-9-18(12)14/h5,7,12,16H,1-4,8-10H2/t12-/m1/s1
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840n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472991
PNG
((R)-4-(((tetrahydro-2H-pyran-4- yl)methoxy)methyl)...)
Show SMILES C(OCc1ccnc2N3CCNC[C@H]3CCc12)C1CCOCC1
Show InChI InChI=1S/C18H27N3O2/c1-2-17-15(13-23-12-14-4-9-22-10-5-14)3-6-20-18(17)21-8-7-19-11-16(1)21/h3,6,14,16,19H,1-2,4-5,7-13H2/t16-/m1/s1
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844n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472928
PNG
((R)-4-isopropyl-6,6a,7,8,9,10-hexahydro-5H- pyrazi...)
Show SMILES CC(C)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C14H21N3/c1-10(2)12-5-6-16-14-13(12)4-3-11-9-15-7-8-17(11)14/h5-6,10-11,15H,3-4,7-9H2,1-2H3/t11-/m1/s1
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874n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473011
PNG
((6aR)-4-ethyl-3-((tetrahydro-2H-pyran-2- yl)methyl...)
Show SMILES CCc1c(CC2CCCCO2)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C19H29N3O/c1-2-17-14(11-16-5-3-4-10-23-16)12-21-19-18(17)7-6-15-13-20-8-9-22(15)19/h12,15-16,20H,2-11,13H2,1H3/t15-,16?/m1/s1
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890n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473012
PNG
((R)-3-cyclobutyl-4-ethyl-6,6a,7,8,9,10-hexahydro- ...)
Show SMILES CCc1c(cnc2N3CCNC[C@H]3CCc12)C1CCC1
Show InChI InChI=1S/C17H25N3/c1-2-14-15-7-6-13-10-18-8-9-20(13)17(15)19-11-16(14)12-4-3-5-12/h11-13,18H,2-10H2,1H3/t13-/m1/s1
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958n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472992
PNG
(4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1,2-a...)
Show SMILES Brc1ccnc2N3CCNCC3CCc12
Show InChI InChI=1S/C11H14BrN3/c12-10-3-4-14-11-9(10)2-1-8-7-13-5-6-15(8)11/h3-4,8,13H,1-2,5-7H2
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966n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472998
PNG
((R)-4-(5-chloropyridin-2-yl)-6,6a,7,8,9,10- hexahy...)
Show SMILES Clc1ccc(nc1)-c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H17ClN4/c17-11-1-4-15(20-9-11)13-5-6-19-16-14(13)3-2-12-10-18-7-8-21(12)16/h1,4-6,9,12,18H,2-3,7-8,10H2/t12-/m1/s1
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1.02E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473004
PNG
(5-methyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1,2-...)
Show SMILES CC1CC2CNCCN2c2ncccc12
Show InChI InChI=1S/C12H17N3/c1-9-7-10-8-13-5-6-15(10)12-11(9)3-2-4-14-12/h2-4,9-10,13H,5-8H2,1H3
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1.08E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM472990
PNG
((6aR)-4-((tetrahydro-2H-pyran-2-yl)methyl)- 6,6a,7...)
Show SMILES C(C1CCCCO1)c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C17H25N3O/c1-2-10-21-15(3-1)11-13-6-7-19-17-16(13)5-4-14-12-18-8-9-20(14)17/h6-7,14-15,18H,1-5,8-12H2/t14-,15?/m1/s1
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1.09E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473003
PNG
((R)-4-(3,3,3-trifluoropropyl)-5,6,6a,7,8,9,10,11- ...)
Show SMILES FC(F)(F)CCc1ccnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C15H20F3N3/c16-15(17,18)6-4-11-5-8-20-14-13(11)3-2-12-10-19-7-1-9-21(12)14/h5,8,12,19H,1-4,6-7,9-10H2/t12-/m1/s1
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1.14E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472991
PNG
((R)-4-(((tetrahydro-2H-pyran-4- yl)methoxy)methyl)...)
Show SMILES C(OCc1ccnc2N3CCNC[C@H]3CCc12)C1CCOCC1
Show InChI InChI=1S/C18H27N3O2/c1-2-17-15(13-23-12-14-4-9-22-10-5-14)3-6-20-18(17)21-8-7-19-11-16(1)21/h3,6,14,16,19H,1-2,4-5,7-13H2/t16-/m1/s1
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1.25E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473008
PNG
((R)-3-(4-ethyl-6,6a,7,8,9,10-hexahydro-5H- pyrazin...)
Show SMILES CCc1c(CCC#N)cnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H22N4/c1-2-14-12(4-3-7-17)10-19-16-15(14)6-5-13-11-18-8-9-20(13)16/h10,13,18H,2-6,8-9,11H2,1H3/t13-/m1/s1
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1.26E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473002
PNG
((R)-4-bromo-5,6,6a,7,8,9,10,11-octahydro- [1,4]dia...)
Show SMILES Brc1ccnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C12H16BrN3/c13-11-4-6-15-12-10(11)3-2-9-8-14-5-1-7-16(9)12/h4,6,9,14H,1-3,5,7-8H2/t9-/m1/s1
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1.39E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473005
PNG
((R)-4-chloro-2-(methylthio)-5,6,6a,7,8,9,10,11- oc...)
Show SMILES CSc1nc(Cl)c2CC[C@@H]3CNCCCN3c2n1
Show InChI InChI=1S/C12H17ClN4S/c1-18-12-15-10(13)9-4-3-8-7-14-5-2-6-17(8)11(9)16-12/h8,14H,2-7H2,1H3/t8-/m1/s1
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1.60E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472991
PNG
((R)-4-(((tetrahydro-2H-pyran-4- yl)methoxy)methyl)...)
Show SMILES C(OCc1ccnc2N3CCNC[C@H]3CCc12)C1CCOCC1
Show InChI InChI=1S/C18H27N3O2/c1-2-17-15(13-23-12-14-4-9-22-10-5-14)3-6-20-18(17)21-8-7-19-11-16(1)21/h3,6,14,16,19H,1-2,4-5,7-13H2/t16-/m1/s1
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1.67E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM473006
PNG
((R)-4-chloro-5,6,6a,7,8,9,10,11- octahydropyrimido...)
Show SMILES Clc1ncnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C11H15ClN4/c12-10-9-3-2-8-6-13-4-1-5-16(8)11(9)15-7-14-10/h7-8,13H,1-6H2/t8-/m1/s1
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1.83E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM472998
PNG
((R)-4-(5-chloropyridin-2-yl)-6,6a,7,8,9,10- hexahy...)
Show SMILES Clc1ccc(nc1)-c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H17ClN4/c17-11-1-4-15(20-9-11)13-5-6-19-16-14(13)3-2-12-10-18-7-8-21(12)16/h1,4-6,9,12,18H,2-3,7-8,10H2/t12-/m1/s1
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3.11E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472992
PNG
(4-bromo-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1,2-a...)
Show SMILES Brc1ccnc2N3CCNCC3CCc12
Show InChI InChI=1S/C11H14BrN3/c12-10-3-4-14-11-9(10)2-1-8-7-13-5-6-15(8)11/h3-4,8,13H,1-2,5-7H2
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3.92E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM472998
PNG
((R)-4-(5-chloropyridin-2-yl)-6,6a,7,8,9,10- hexahy...)
Show SMILES Clc1ccc(nc1)-c1ccnc2N3CCNC[C@H]3CCc12
Show InChI InChI=1S/C16H17ClN4/c17-11-1-4-15(20-9-11)13-5-6-19-16-14(13)3-2-12-10-18-7-8-21(12)16/h1,4-6,9,12,18H,2-3,7-8,10H2/t12-/m1/s1
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5.39E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM473006
PNG
((R)-4-chloro-5,6,6a,7,8,9,10,11- octahydropyrimido...)
Show SMILES Clc1ncnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C11H15ClN4/c12-10-9-3-2-8-6-13-4-1-5-16(8)11(9)15-7-14-10/h7-8,13H,1-6H2/t8-/m1/s1
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5.56E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473005
PNG
((R)-4-chloro-2-(methylthio)-5,6,6a,7,8,9,10,11- oc...)
Show SMILES CSc1nc(Cl)c2CC[C@@H]3CNCCCN3c2n1
Show InChI InChI=1S/C12H17ClN4S/c1-18-12-15-10(13)9-4-3-8-7-14-5-2-6-17(8)11(9)16-12/h8,14H,2-7H2,1H3/t8-/m1/s1
PDB
MMDB

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1.23E+4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM473006
PNG
((R)-4-chloro-5,6,6a,7,8,9,10,11- octahydropyrimido...)
Show SMILES Clc1ncnc2N3CCCNC[C@H]3CCc12
Show InChI InChI=1S/C11H15ClN4/c12-10-9-3-2-8-6-13-4-1-5-16(8)11(9)15-7-14-10/h7-8,13H,1-6H2/t8-/m1/s1
PDB
MMDB

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antibodypedia
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US Patent
1.00E+5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...


US Patent US10836764 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%