BindingDB logo
myBDB logout

Patent code US10836773

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM458383
PNG
(1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...)
Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1ccc2CN(Cc2n1)C(C)=O
Show InChI InChI=1S/C23H25FN4O2S/c1-13-6-18(30-23-5-4-16-9-28(15(3)29)12-21(16)26-23)11-27(13)10-17-7-20-22(8-19(17)24)31-14(2)25-20/h4-5,7-8,13,18H,6,9-12H2,1-3H3/t13-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.214n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...


US Patent US10836773 (2020)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM458387
PNG
(1-[2-[(3R,5S)-1-[(1S)-1-(6-fluoro-2-methyl-1,3-ben...)
Show SMILES C[C@H](N1C[C@@H](C[C@@H]1C)Oc1ccc2CN(Cc2n1)C(C)=O)c1cc2nc(C)sc2cc1F
Show InChI InChI=1S/C24H27FN4O2S/c1-13-7-18(31-24-6-5-17-10-28(16(4)30)12-22(17)27-24)11-29(13)14(2)19-8-21-23(9-20(19)25)32-15(3)26-21/h5-6,8-9,13-14,18H,7,10-12H2,1-4H3/t13-,14-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.385n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...


US Patent US10836773 (2020)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM458382
PNG
(1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...)
Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1ncc2CN(Cc2n1)C(C)=O
Show InChI InChI=1S/C22H24FN5O2S/c1-12-4-17(30-22-24-7-16-9-28(14(3)29)11-20(16)26-22)10-27(12)8-15-5-19-21(6-18(15)23)31-13(2)25-19/h5-7,12,17H,4,8-11H2,1-3H3/t12-,17+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.465n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...


US Patent US10836773 (2020)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM458386
PNG
(1-[2-[(3R,5S)-1-[(1S)-1-(6-fluoro-2-methyl-1,3-ben...)
Show SMILES C[C@H](N1C[C@@H](C[C@@H]1C)Oc1ncc2CN(Cc2n1)C(C)=O)c1cc2nc(C)sc2cc1F
Show InChI InChI=1S/C23H26FN5O2S/c1-12-5-17(31-23-25-8-16-9-28(15(4)30)11-21(16)27-23)10-29(12)13(2)18-6-20-22(7-19(18)24)32-14(3)26-20/h6-8,12-13,17H,5,9-11H2,1-4H3/t12-,13-,17+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.495n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...


US Patent US10836773 (2020)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM458385
PNG
(1-[3-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...)
Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1cnc2CN(Cc2c1)C(C)=O
Show InChI InChI=1S/C23H25FN4O2S/c1-13-4-19(30-18-5-17-10-28(15(3)29)12-22(17)25-8-18)11-27(13)9-16-6-21-23(7-20(16)24)31-14(2)26-21/h5-8,13,19H,4,9-12H2,1-3H3/t13-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.592n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...


US Patent US10836773 (2020)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM458384
PNG
(1-[6-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...)
Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1cc2CN(Cc2cn1)C(C)=O
Show InChI InChI=1S/C23H25FN4O2S/c1-13-4-19(30-23-6-16-9-28(15(3)29)11-18(16)8-25-23)12-27(13)10-17-5-21-22(7-20(17)24)31-14(2)26-21/h5-8,13,19H,4,9-12H2,1-3H3/t13-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.782n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...


US Patent US10836773 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%