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Patent code US10844044

Compile Data Set for Download or QSAR

Found 364 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473225
PNG
(US10844044, Example 283)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(CN2CCOC2=N)cc(c1F)-c1ccc(F)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C29H25F6N3O2/c1-15-10-18(4-7-24(15)31)26(17-2-3-17)37-27(39)22-12-16(14-38-8-9-40-28(38)36)11-21(25(22)32)20-6-5-19(30)13-23(20)29(33,34)35/h4-7,10-13,17,26,36H,2-3,8-9,14H2,1H3,(H,37,39)/t26-/m0/s1
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0.0200n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473480
PNG
(US10844044, Example 72)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1)-c1ncc(F)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C29H26F5N5O/c1-16-9-19(5-6-24(16)31)25(18-3-4-18)37-27(40)21-11-17(15-39-8-7-38(2)28(39)35)10-20(12-21)26-23(29(32,33)34)13-22(30)14-36-26/h5-14,18,25,35H,3-4,15H2,1-2H3,(H,37,40)/t25-/m0/s1
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0.0500n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473215
PNG
(US10844044, Example 98)
Show SMILES COc1cc(CNC(=O)c2cc(Cn3ccn(C)c3=N)cc(c2)-c2ccc(F)cc2C(F)(F)F)cc(OC)c1
Show InChI InChI=1S/C28H26F4N4O3/c1-35-6-7-36(27(35)33)16-18-8-19(24-5-4-21(29)13-25(24)28(30,31)32)12-20(9-18)26(37)34-15-17-10-22(38-2)14-23(11-17)39-3/h4-14,33H,15-16H2,1-3H3,(H,34,37)
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0.0600n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473393
PNG
(US10844044, Example 232)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccoc2=N)cc(c1)-c1ccc(F)cc1C)C1CC1
Show InChI InChI=1S/C29H27F2N3O2/c1-17-12-24(30)6-7-25(17)22-13-19(16-34-9-10-36-29(34)32)14-23(15-22)28(35)33-27(20-3-4-20)21-5-8-26(31)18(2)11-21/h5-15,20,27,32H,3-4,16H2,1-2H3,(H,33,35)/t27-/m0/s1
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0.0600n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473383
PNG
(US10844044, Example 230)
Show SMILES C[C@H](NC(=O)c1cc(Cn2ccoc2=N)cc(c1)-c1ccc(F)cc1C)c1ccc(F)c(C)c1
Show InChI InChI=1S/C27H25F2N3O2/c1-16-11-23(28)5-6-24(16)21-12-19(15-32-8-9-34-27(32)30)13-22(14-21)26(33)31-18(3)20-4-7-25(29)17(2)10-20/h4-14,18,30H,15H2,1-3H3,(H,31,33)/t18-/m0/s1
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0.0600n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473208
PNG
(US10844044, Example 187)
Show SMILES Cn1ccn(Cc2cc(cc(c2)-c2ncc(F)cc2C(F)(F)F)C(=O)N[C@@H](C2CC2)c2ccc(Cl)c(Cl)c2)c1=N
Show InChI InChI=1S/C28H23Cl2F4N5O/c1-38-6-7-39(27(38)35)14-15-8-18(25-21(28(32,33)34)12-20(31)13-36-25)10-19(9-15)26(40)37-24(16-2-3-16)17-4-5-22(29)23(30)11-17/h4-13,16,24,35H,2-3,14H2,1H3,(H,37,40)/t24-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473232
PNG
(US10844044, Example 193)
Show SMILES CC(C)n1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C30H32F4N6O/c1-17(2)40-16-24(27(37-40)30(32,33)34)22-12-19(15-39-10-9-38(4)29(39)35)13-23(14-22)28(41)36-26(20-5-6-20)21-7-8-25(31)18(3)11-21/h7-14,16-17,20,26,35H,5-6,15H2,1-4H3,(H,36,41)/t26-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473236
PNG
(US10844044, Example 194)
Show SMILES CC(C)n1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C3CC3)c2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C32H34F4N6O/c1-18(2)42-17-26(29(39-42)32(34,35)36)23-13-20(16-40-10-11-41(31(40)37)25-7-8-25)14-24(15-23)30(43)38-28(21-4-5-21)22-6-9-27(33)19(3)12-22/h6,9-15,17-18,21,25,28,37H,4-5,7-8,16H2,1-3H3,(H,38,43)/t28-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473244
PNG
(US10844044, Example 105)
Show SMILES Cc1ccnc(c1)C(NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1F)-c1ccc(F)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C29H26F5N5O/c1-16-7-8-36-24(11-16)26(18-3-4-18)37-27(40)22-13-17(15-39-10-9-38(2)28(39)35)12-21(25(22)31)20-6-5-19(30)14-23(20)29(32,33)34/h5-14,18,26,35H,3-4,15H2,1-2H3,(H,37,40)
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473249
PNG
(US10844044, Example 197)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C3CC3)c2=N)cc(c1)C(=O)NCc1ccc(F)c(C)c1
Show InChI InChI=1S/C28H28F4N6O/c1-3-37-16-23(25(35-37)28(30,31)32)20-11-19(15-36-8-9-38(27(36)33)22-5-6-22)12-21(13-20)26(39)34-14-18-4-7-24(29)17(2)10-18/h4,7-13,16,22,33H,3,5-6,14-15H2,1-2H3,(H,34,39)
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473274
PNG
(US10844044, Example 295)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(CN2CCOC2=N)cc(c1)C(=O)NCc1ccc(F)c(C)c1
Show InChI InChI=1S/C25H25F4N5O2/c1-3-34-14-20(22(32-34)25(27,28)29)18-9-17(13-33-6-7-36-24(33)30)10-19(11-18)23(35)31-12-16-4-5-21(26)15(2)8-16/h4-5,8-11,14,30H,3,6-7,12-13H2,1-2H3,(H,31,35)
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473287
PNG
(US10844044, Example 298)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccoc2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C27H24ClF4N5O2/c1-2-37-14-20(24(35-37)27(30,31)32)18-9-15(13-36-7-8-39-26(36)33)10-19(11-18)25(38)34-23(16-3-4-16)17-5-6-22(29)21(28)12-17/h5-12,14,16,23,33H,2-4,13H2,1H3,(H,34,38)/t23-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473290
PNG
(US10844044, Example 207)
Show SMILES COc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C28H28F4N6O2/c1-36-8-9-38(27(36)33)14-16-10-19(21-15-37(2)35-25(21)28(30,31)32)12-20(11-16)26(39)34-24(17-4-5-17)18-6-7-22(29)23(13-18)40-3/h6-13,15,17,24,33H,4-5,14H2,1-3H3,(H,34,39)/t24-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473330
PNG
(US10844044, Example 217)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1)C1(CC1)C(F)(F)F)C1CC1
Show InChI InChI=1S/C27H28F4N4O/c1-16-11-19(5-6-22(16)28)23(18-3-4-18)33-24(36)20-12-17(15-35-10-9-34(2)25(35)32)13-21(14-20)26(7-8-26)27(29,30)31/h5-6,9-14,18,23,32H,3-4,7-8,15H2,1-2H3,(H,33,36)/t23-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473376
PNG
(US10844044, Example 320)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccsc2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C28H27F4N5OS/c1-3-37-15-22(25(35-37)28(30,31)32)20-11-17(14-36-8-9-39-27(36)33)12-21(13-20)26(38)34-24(18-4-5-18)19-6-7-23(29)16(2)10-19/h6-13,15,18,24,33H,3-5,14H2,1-2H3,(H,34,38)/t24-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473384
PNG
(US10844044, Example 322)
Show SMILES CC(C)n1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccsc2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C29H29F4N5OS/c1-16(2)38-15-23(26(36-38)29(31,32)33)21-11-18(14-37-8-9-40-28(37)34)12-22(13-21)27(39)35-25(19-4-5-19)20-6-7-24(30)17(3)10-20/h6-13,15-16,19,25,34H,4-5,14H2,1-3H3,(H,35,39)/t25-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473398
PNG
(US10844044, Example 325)
Show SMILES Cc1cc(ncc1F)[C@@H](NC(=O)c1cc(Cn2ccsc2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C26H24F4N6OS/c1-14-7-21(32-11-20(14)27)22(16-3-4-16)33-24(37)18-9-15(12-36-5-6-38-25(36)31)8-17(10-18)19-13-35(2)34-23(19)26(28,29)30/h5-11,13,16,22,31H,3-4,12H2,1-2H3,(H,33,37)/t22-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473402
PNG
(US10844044, Example 326)
Show SMILES Cc1cc(ncc1F)[C@@H](NC(=O)c1cc(CN2CCSC2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C26H26F4N6OS/c1-14-7-21(32-11-20(14)27)22(16-3-4-16)33-24(37)18-9-15(12-36-5-6-38-25(36)31)8-17(10-18)19-13-35(2)34-23(19)26(28,29)30/h7-11,13,16,22,31H,3-6,12H2,1-2H3,(H,33,37)/t22-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473406
PNG
(US10844044, Example 327)
Show SMILES COc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccsc2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C27H25F4N5O2S/c1-35-14-20(24(34-35)27(29,30)31)18-9-15(13-36-7-8-39-26(36)32)10-19(11-18)25(37)33-23(16-3-4-16)17-5-6-21(28)22(12-17)38-2/h5-12,14,16,23,32H,3-4,13H2,1-2H3,(H,33,37)/t23-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473407
PNG
(US10844044, Example 54)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1)-c1ccc(F)cc1C)C1CC1
Show InChI InChI=1S/C30H30F2N4O/c1-18-13-25(31)7-8-26(18)23-14-20(17-36-11-10-35(3)30(36)33)15-24(16-23)29(37)34-28(21-4-5-21)22-6-9-27(32)19(2)12-22/h6-16,21,28,33H,4-5,17H2,1-3H3,(H,34,37)/t28-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473435
PNG
(US10844044, Example 335)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(CN2CCCC2=N)cc(c1)-c1ccc(F)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C30H28F5N3O/c1-17-11-20(6-9-26(17)32)28(19-4-5-19)37-29(39)22-13-18(16-38-10-2-3-27(38)36)12-21(14-22)24-8-7-23(31)15-25(24)30(33,34)35/h6-9,11-15,19,28,36H,2-5,10,16H2,1H3,(H,37,39)/t28-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473461
PNG
(US10844044, Example 158)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C3CC3)c2=N)cc(c1)-c1ccc(F)cc1C(F)F)C1CC1
Show InChI InChI=1S/C32H30F4N4O/c1-18-12-21(4-9-28(18)34)29(20-2-3-20)38-31(41)23-14-19(17-39-10-11-40(32(39)37)25-6-7-25)13-22(15-23)26-8-5-24(33)16-27(26)30(35)36/h4-5,8-16,20,25,29-30,37H,2-3,6-7,17H2,1H3,(H,38,41)/t29-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473511
PNG
(US10844044, Example 354)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2cc(F)ccc2=N)cc(c1)-c1cccnc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C30H25F5N4O/c1-17-11-20(6-8-25(17)32)27(19-4-5-19)38-29(40)22-13-18(15-39-16-23(31)7-9-26(39)36)12-21(14-22)24-3-2-10-37-28(24)30(33,34)35/h2-3,6-14,16,19,27,36H,4-5,15H2,1H3,(H,38,40)/t27-/m0/s1
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Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473534
PNG
(US10844044, Example 268)
Show SMILES Cn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccoc2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H22Cl2F3N5O2/c1-35-13-19(23(34-35)26(29,30)31)17-8-14(12-36-6-7-38-25(36)32)9-18(10-17)24(37)33-22(15-2-3-15)16-4-5-20(27)21(28)11-16/h4-11,13,15,22,32H,2-3,12H2,1H3,(H,33,37)/t22-/m0/s1
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Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473538
PNG
(US10844044, Example 269)
Show SMILES Cn1cc(c(n1)C(F)(F)F)-c1cc(CN2CCOC2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H24Cl2F3N5O2/c1-35-13-19(23(34-35)26(29,30)31)17-8-14(12-36-6-7-38-25(36)32)9-18(10-17)24(37)33-22(15-2-3-15)16-4-5-20(27)21(28)11-16/h4-5,8-11,13,15,22,32H,2-3,6-7,12H2,1H3,(H,33,37)/t22-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473545
PNG
(US10844044, Example 179)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C)c2=N)cc(OC(F)(F)F)c1)C1CC1
Show InChI InChI=1S/C24H24F4N4O2/c1-14-9-17(5-6-20(14)25)21(16-3-4-16)30-22(33)18-10-15(11-19(12-18)34-24(26,27)28)13-32-8-7-31(2)23(32)29/h5-12,16,21,29H,3-4,13H2,1-2H3,(H,30,33)/t21-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473253
PNG
(US10844044, Example 198)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NCc1ccc(F)c(C)c1
Show InChI InChI=1S/C26H26F4N6O/c1-4-36-15-21(23(33-36)26(28,29)30)19-10-18(14-35-8-7-34(3)25(35)31)11-20(12-19)24(37)32-13-17-5-6-22(27)16(2)9-17/h5-12,15,31H,4,13-14H2,1-3H3,(H,32,37)
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473285
PNG
(US10844044, Example 115)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C3CC3)c2=N)cc(c1)-c1cccnc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C31H29F4N5O/c1-18-13-21(6-9-26(18)32)27(20-4-5-20)38-29(41)23-15-19(17-39-11-12-40(30(39)36)24-7-8-24)14-22(16-23)25-3-2-10-37-28(25)31(33,34)35/h2-3,6,9-16,20,24,27,36H,4-5,7-8,17H2,1H3,(H,38,41)/t27-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473298
PNG
(US10844044, Example 209)
Show SMILES CCOc1c(cc(Cn2ccn(C)c2=N)cc1-c1cn(C)nc1C(F)(F)F)C(=O)N[C@@H](C)c1ccc(F)c(C)c1
Show InChI InChI=1S/C28H30F4N6O2/c1-6-40-24-20(22-15-37(5)35-25(22)28(30,31)32)12-18(14-38-10-9-36(4)27(38)33)13-21(24)26(39)34-17(3)19-7-8-23(29)16(2)11-19/h7-13,15,17,33H,6,14H2,1-5H3,(H,34,39)/t17-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473306
PNG
(US10844044, Example 157 | US10844044, Example 211)
Show SMILES Cn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H25Cl2F3N6O/c1-36-7-8-38(26(36)33)13-15-9-18(20-14-37(2)35-24(20)27(30,31)32)11-19(10-15)25(39)34-23(16-3-4-16)17-5-6-21(28)22(29)12-17/h5-12,14,16,23,33H,3-4,13H2,1-2H3,(H,34,39)/t23-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473318
PNG
(US10844044, Example 214)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C28H27ClF4N6O/c1-3-39-15-21(25(36-39)28(31,32)33)19-10-16(14-38-9-8-37(2)27(38)34)11-20(12-19)26(40)35-24(17-4-5-17)18-6-7-23(30)22(29)13-18/h6-13,15,17,24,34H,3-5,14H2,1-2H3,(H,35,40)/t24-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473322
PNG
(US10844044, Example 215)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(CN2CCN(C)C2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C29H32F4N6O/c1-4-39-16-23(26(36-39)29(31,32)33)21-12-18(15-38-10-9-37(3)28(38)34)13-22(14-21)27(40)35-25(19-5-6-19)20-7-8-24(30)17(2)11-20/h7-8,11-14,16,19,25,34H,4-6,9-10,15H2,1-3H3,(H,35,40)/t25-/m0/s1
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Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473394
PNG
(US10844044, Example 324)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccsc2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C27H24ClF4N5OS/c1-2-37-14-20(24(35-37)27(30,31)32)18-9-15(13-36-7-8-39-26(36)33)10-19(11-18)25(38)34-23(16-3-4-16)17-5-6-21(28)22(29)12-17/h5-12,14,16,23,33H,2-4,13H2,1H3,(H,34,38)/t23-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473458
PNG
(US10844044, Example 248)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccoc2=N)cc(c1)-c1ccc(F)cc1Cl)C1CC1
Show InChI InChI=1S/C28H24ClF2N3O2/c1-16-10-19(4-7-25(16)31)26(18-2-3-18)33-27(35)21-12-17(15-34-8-9-36-28(34)32)11-20(13-21)23-6-5-22(30)14-24(23)29/h4-14,18,26,32H,2-3,15H2,1H3,(H,33,35)/t26-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473507
PNG
(US10844044, Example 353)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2cc(F)ccc2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C29H26F5N5O/c1-16-9-19(5-7-24(16)31)26(18-3-4-18)36-28(40)21-11-17(13-39-14-22(30)6-8-25(39)35)10-20(12-21)23-15-38(2)37-27(23)29(32,33)34/h5-12,14-15,18,26,35H,3-4,13H2,1-2H3,(H,36,40)/t26-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473532
PNG
(US10844044, Example 85)
Show SMILES CCC(=O)CNC(=O)CC(NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1)-c1ccc(F)cc1C(F)(F)F)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C32H29Cl2F4N5O3/c1-3-23(44)16-40-29(45)15-28(19-4-7-26(33)27(34)13-19)41-30(46)21-11-18(17-43-9-8-42(2)31(43)39)10-20(12-21)24-6-5-22(35)14-25(24)32(36,37)38/h4-14,28,39H,3,15-17H2,1-2H3,(H,40,45)(H,41,46)
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Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473237
PNG
(US10844044, Example 286)
Show SMILES CC(C)n1cc(c(n1)C(F)(F)F)-c1cc(CN2CCOC2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H28F5N5O2/c1-15(2)38-14-21(25(36-38)28(31,32)33)19-9-16(13-37-7-8-40-27(37)34)10-20(11-19)26(39)35-24(17-3-4-17)18-5-6-22(29)23(30)12-18/h5-6,9-12,14-15,17,24,34H,3-4,7-8,13H2,1-2H3,(H,35,39)/t24-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473242
PNG
(US10844044, Example 287)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(CN2CCOC2=N)cc(c1)-c1cc(nn1C)C(F)(F)F)C1CC1
Show InChI InChI=1S/C27H27F4N5O2/c1-15-9-18(5-6-21(15)28)24(17-3-4-17)33-25(37)20-11-16(14-36-7-8-38-26(36)32)10-19(12-20)22-13-23(27(29,30)31)34-35(22)2/h5-6,9-13,17,24,32H,3-4,7-8,14H2,1-2H3,(H,33,37)/t24-/m0/s1
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US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473260
PNG
(US10844044, Example 109)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1F)-c1ccc(F)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C30H26F6N4O/c1-16-11-19(5-8-25(16)32)27(18-3-4-18)38-28(41)23-13-17(15-40-10-9-39(2)29(40)37)12-22(26(23)33)21-7-6-20(31)14-24(21)30(34,35)36/h5-14,18,27,37H,3-4,15H2,1-2H3,(H,38,41)/t27-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473310
PNG
(US10844044, Example 212)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C29H30F4N6O/c1-4-39-16-23(26(36-39)29(31,32)33)21-12-18(15-38-10-9-37(3)28(38)34)13-22(14-21)27(40)35-25(19-5-6-19)20-7-8-24(30)17(2)11-20/h7-14,16,19,25,34H,4-6,15H2,1-3H3,(H,35,40)/t25-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473319
PNG
(US10844044, Example 306)
Show SMILES COc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccoc2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C27H25F4N5O3/c1-35-14-20(24(34-35)27(29,30)31)18-9-15(13-36-7-8-39-26(36)32)10-19(11-18)25(37)33-23(16-3-4-16)17-5-6-21(28)22(12-17)38-2/h5-12,14,16,23,32H,3-4,13H2,1-2H3,(H,33,37)/t23-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473338
PNG
(US10844044, Example 219)
Show SMILES CN1CCN(Cc2cc(cc(c2)-c2cccnc2C(F)(F)F)C(=O)N[C@@H](C2CC2)c2ccc(F)c(Cl)c2)C1=N
Show InChI InChI=1S/C28H26ClF4N5O/c1-37-9-10-38(27(37)34)15-16-11-19(21-3-2-8-35-25(21)28(31,32)33)13-20(12-16)26(39)36-24(17-4-5-17)18-6-7-23(30)22(29)14-18/h2-3,6-8,11-14,17,24,34H,4-5,9-10,15H2,1H3,(H,36,39)/t24-/m0/s1
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<0.100n/an/an/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473349
PNG
(US10844044, Example 131)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1F)-c1cccnc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C29H26F5N5O/c1-16-12-19(7-8-23(16)30)25(18-5-6-18)37-27(40)22-14-17(15-39-11-10-38(2)28(39)35)13-21(24(22)31)20-4-3-9-36-26(20)29(32,33)34/h3-4,7-14,18,25,35H,5-6,15H2,1-2H3,(H,37,40)/t25-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473380
PNG
(US10844044, Example 321)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccsc2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C27H25F4N5OS/c1-15-9-18(5-6-22(15)28)23(17-3-4-17)33-25(37)20-11-16(13-36-7-8-38-26(36)32)10-19(12-20)21-14-35(2)34-24(21)27(29,30)31/h5-12,14,17,23,32H,3-4,13H2,1-2H3,(H,33,37)/t23-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473443
PNG
(US10844044, Example 337)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(CN2CCCC2=N)cc(c1)-c1cn(C)nc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C28H29F4N5O/c1-16-10-19(7-8-23(16)29)25(18-5-6-18)34-27(38)21-12-17(14-37-9-3-4-24(37)33)11-20(13-21)22-15-36(2)35-26(22)28(30,31)32/h7-8,10-13,15,18,25,33H,3-6,9,14H2,1-2H3,(H,34,38)/t25-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473477
PNG
(US10844044, Example 162)
Show SMILES CCn1cc(c(n1)C(F)(F)F)-c1cc(Cn2ccn(C3CC3)c2=N)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C30H29Cl2F3N6O/c1-2-40-16-23(27(38-40)30(33,34)35)20-11-17(15-39-9-10-41(29(39)36)22-6-7-22)12-21(13-20)28(42)37-26(18-3-4-18)19-5-8-24(31)25(32)14-19/h5,8-14,16,18,22,26,36H,2-4,6-7,15H2,1H3,(H,37,42)/t26-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473478
PNG
(US10844044, Example 253)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(CN2CCOC2=N)cc(c1)-c1cccnc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C28H26F4N4O2/c1-16-11-19(6-7-23(16)29)24(18-4-5-18)35-26(37)21-13-17(15-36-9-10-38-27(36)33)12-20(14-21)22-3-2-8-34-25(22)28(30,31)32/h2-3,6-8,11-14,18,24,33H,4-5,9-10,15H2,1H3,(H,35,37)/t24-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473554
PNG
(US10844044, Example 273)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(CN2CCOC2=N)cc(c1)-c1ccc(F)cc1OC(F)F)C1CC1
Show InChI InChI=1S/C29H27F4N3O3/c1-16-10-19(4-7-24(16)31)26(18-2-3-18)35-27(37)21-12-17(15-36-8-9-38-29(36)34)11-20(13-21)23-6-5-22(30)14-25(23)39-28(32)33/h4-7,10-14,18,26,28,34H,2-3,8-9,15H2,1H3,(H,35,37)/t26-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473558
PNG
(US10844044, Example 274)
Show SMILES Cc1cc(ccc1F)[C@@H](NC(=O)c1cc(Cn2ccoc2=N)cc(c1)-c1ccc(F)cc1C(F)F)C1CC1
Show InChI InChI=1S/C29H25F4N3O2/c1-16-10-19(4-7-25(16)31)26(18-2-3-18)35-28(37)21-12-17(15-36-8-9-38-29(36)34)11-20(13-21)23-6-5-22(30)14-24(23)27(32)33/h4-14,18,26-27,34H,2-3,15H2,1H3,(H,35,37)/t26-/m0/s1
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM473194
PNG
(US10844044, Example 2)
Show SMILES COc1ncc(C)cc1-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NC(C1CC1)c1cc(C)ccn1
Show InChI InChI=1S/C29H32N6O2/c1-18-7-8-31-25(12-18)26(21-5-6-21)33-27(36)23-14-20(17-35-10-9-34(3)29(35)30)13-22(15-23)24-11-19(2)16-32-28(24)37-4/h7-16,21,26,30H,5-6,17H2,1-4H3,(H,33,36)
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Vanderbilt University

US Patent


Assay Description
A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...


US Patent US10844044 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%