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Patent code US10844062

Compile Data Set for Download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473585
PNG
(US10844062, Example 21)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)36-21-12-18(8-9-20(21)28)35-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)
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US Patent
n/an/a 4.10n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473613
PNG
(US10844062, Example 49)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)35-18-8-9-20(28)21(12-18)36-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,36)(H,35,37)(H,31,32,33,34)
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n/an/a 10n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473594
PNG
(US10844062, Example 30)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H15F4N7O/c25-17-7-6-15(10-18(17)35-23(36)13-3-1-4-14(9-13)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473640
PNG
(US10844062, Example 76)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F4N7O/c26-18-7-6-16(11-19(18)36-20(37)10-14-3-1-4-15(9-14)25(27,28)29)35-23-17(5-2-8-30-23)21-22-24(33-12-31-21)34-13-32-22/h1-9,11-13H,10H2,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473190
PNG
(US10844062, Example 1)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H14F5N7O/c25-15-6-7-16(35-23(37)12-3-1-4-13(9-12)24(27,28)29)17(26)19(15)36-21-14(5-2-8-30-21)18-20-22(33-10-31-18)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34)
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n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473593
PNG
(US10844062, Example 29)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-7-3-6-16(12-17)26(37)36-20-10-4-9-19(21(20)28)35-24-18(8-5-11-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473600
PNG
(US10844062, Example 36)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C24H14F5N7O/c25-14-7-12(6-13(8-14)24(27,28)29)23(37)36-18-9-15(3-4-17(18)26)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473573
PNG
(US10844062, Example 9)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(11-16)26(38)36-19-9-8-18(28)22(20(19)29)37-24-17(7-4-10-31-24)21-23-25(34-13-32-21)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,37)(H,36,38)(H,32,33,34,35)
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n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473587
PNG
(US10844062, Example 23)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C27H22N8O/c1-27(2,14-28)18-7-3-6-17(12-18)26(36)35-20-9-4-8-19(13-20)34-24-21(10-5-11-29-24)22-23-25(32-15-30-22)33-16-31-23/h3-13,15-16H,1-2H3,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 14n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473629
PNG
(US10844062, Example 65)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H14F7N7O/c26-17-4-3-15(38-21-16(2-1-5-33-21)19-20-22(36-10-34-19)37-11-35-20)9-18(17)39-23(40)12-6-13(24(27,28)29)8-14(7-12)25(30,31)32/h1-11H,(H,33,38)(H,39,40)(H,34,35,36,37)
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n/an/a 21n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473648
PNG
(US10844062, Example 84)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)c(F)cc1F
Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-6-3-5-16(11-17)27(38)37-23-13-22(20(29)12-21(23)30)36-26-18(7-4-9-32-26)24-19-8-10-33-25(19)35-15-34-24/h3-13,15H,1-2H3,(H,32,36)(H,37,38)(H,33,34,35)
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n/an/a 21n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473642
PNG
(US10844062, Example 78)
Show SMILES Fc1cc(NC(=O)c2ccc(CC#N)cc2)ccc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H17FN8O/c26-19-12-17(33-25(35)16-5-3-15(4-6-16)9-10-27)7-8-20(19)34-23-18(2-1-11-28-23)21-22-24(31-13-29-21)32-14-30-22/h1-8,11-14H,9H2,(H,28,34)(H,33,35)(H,29,30,31,32)
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n/an/a 28n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473596
PNG
(US10844062, Example 32)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)cc1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(9-16)26(38)37-21-11-20(18(28)10-19(21)29)36-24-17(7-4-8-31-24)22-23-25(34-13-32-22)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,36)(H,37,38)(H,32,33,34,35)
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n/an/a 29n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473641
PNG
(US10844062, Example 77)
Show SMILES Fc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(CC#N)c1
Show InChI InChI=1S/C25H17FN8O/c26-19-7-6-16(25(35)33-17-4-1-3-15(11-17)8-9-27)12-20(19)34-23-18(5-2-10-28-23)21-22-24(31-13-29-21)32-14-30-22/h1-7,10-14H,8H2,(H,28,34)(H,33,35)(H,29,30,31,32)
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n/an/a 35n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473631
PNG
(US10844062, Example 67)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl
Show InChI InChI=1S/C24H14ClF4N7O/c25-17-4-3-15(9-18(17)36-23(37)12-6-13(24(27,28)29)8-14(26)7-12)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 40n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473638
PNG
(US10844062, Example 74)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H15ClF4N8O/c25-16-5-3-12(8-15(16)24(27,28)29)36-23(38)37-18-9-13(4-6-17(18)26)35-21-14(2-1-7-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H2,36,37,38)(H,31,32,33,34)
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n/an/a 43n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473637
PNG
(US10844062, Example 73)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H15F4N7O/c25-18-7-6-15(10-17(18)23(36)35-14-4-1-3-13(9-14)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 52n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473592
PNG
(US10844062, Example 28)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C24H13F6N7O/c25-13-7-11(6-12(8-13)24(28,29)30)23(38)36-16-4-3-15(26)19(17(16)27)37-21-14(2-1-5-31-21)18-20-22(34-9-32-18)35-10-33-20/h1-10H,(H,31,37)(H,36,38)(H,32,33,34,35)
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n/an/a 74n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473653
PNG
(US10844062, Example 91)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F
Show InChI InChI=1S/C28H22FN7O/c1-28(2,15-30)18-6-3-5-17(13-18)27(37)36-23-14-19(8-9-22(23)29)35-26-20(7-4-11-31-26)24-21-10-12-32-25(21)34-16-33-24/h3-14,16H,1-2H3,(H,31,35)(H,36,37)(H,32,33,34)
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US Patent
n/an/a 76n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473605
PNG
(US10844062, Example 41)
Show SMILES CC(C)(C#N)c1cc(ccc1Cl)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H19ClF2N8O/c1-27(2,11-31)16-10-14(5-6-17(16)28)26(39)37-19-8-7-18(29)22(20(19)30)38-24-15(4-3-9-32-24)21-23-25(35-12-33-21)36-13-34-23/h3-10,12-13H,1-2H3,(H,32,38)(H,37,39)(H,33,34,35,36)
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US Patent
n/an/a 82n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473654
PNG
(US10844062, Example 92)
Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F
Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-10-16(11-18(29)12-17)27(38)37-23-13-19(5-6-22(23)30)36-26-20(4-3-8-32-26)24-21-7-9-33-25(21)35-15-34-24/h3-13,15H,1-2H3,(H,32,36)(H,37,38)(H,33,34,35)
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US Patent
n/an/a 87n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473630
PNG
(US10844062, Example 66)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl
Show InChI InChI=1S/C24H15ClF3N7O/c25-17-7-6-15(10-18(17)35-23(36)13-3-1-4-14(9-13)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
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US Patent
n/an/a 89n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473649
PNG
(US10844062, Example 85)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-6-3-5-16(13-17)27(38)36-21-9-8-20(29)24(22(21)30)37-26-18(7-4-11-32-26)23-19-10-12-33-25(19)35-15-34-23/h3-13,15H,1-2H3,(H,32,37)(H,36,38)(H,33,34,35)
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US Patent
n/an/a 89n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473614
PNG
(US10844062, Example 50)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H15F4N7O/c25-17-7-6-15(34-23(36)13-3-1-4-14(9-13)24(26,27)28)10-18(17)35-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,35)(H,34,36)(H,30,31,32,33)
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n/an/a 90n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473604
PNG
(US10844062, Example 40)
Show SMILES [O-][N+](=O)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C24H13F5N8O3/c25-15-3-4-16(35-23(38)11-6-12(24(27,28)29)8-13(7-11)37(39)40)17(26)19(15)36-21-14(2-1-5-30-21)18-20-22(33-9-31-18)34-10-32-20/h1-10H,(H,30,36)(H,35,38)(H,31,32,33,34)
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US Patent
n/an/a 96n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473652
PNG
(US10844062, Example 88)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F
Show InChI InChI=1S/C25H15F5N6O/c26-15-9-13(8-14(10-15)25(28,29)30)24(37)36-20-11-16(3-4-19(20)27)35-23-17(2-1-6-31-23)21-18-5-7-32-22(18)34-12-33-21/h1-12H,(H,31,35)(H,36,37)(H,32,33,34)
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US Patent
n/an/a 109n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473611
PNG
(US10844062, Example 47)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C24H17F2N7O/c1-13-4-2-5-14(10-13)24(34)32-17-8-7-16(25)20(18(17)26)33-22-15(6-3-9-27-22)19-21-23(30-11-28-19)31-12-29-21/h2-12H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31)
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n/an/a 118n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473645
PNG
(US10844062, Example 81)
Show SMILES Fc1ccc(cc1)N1CCN(C(=O)Nc2ccc(F)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2F)C1=O
Show InChI InChI=1S/C26H18F3N9O2/c27-14-3-5-15(6-4-14)37-10-11-38(26(37)40)25(39)35-18-8-7-17(28)21(19(18)29)36-23-16(2-1-9-30-23)20-22-24(33-12-31-20)34-13-32-22/h1-9,12-13H,10-11H2,(H,30,36)(H,35,39)(H,31,32,33,34)
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US Patent
n/an/a 121n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473656
PNG
(US10844062, Example 139)
Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C25H17F4N7O/c1-13-7-14(9-15(8-13)25(27,28)29)24(37)36-19-10-16(4-5-18(19)26)35-22-17(3-2-6-30-22)20-21-23(33-11-31-20)34-12-32-21/h2-12H,1H3,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 126n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473597
PNG
(US10844062, Example 33)
Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-8-15(9-17(28)10-16)26(38)37-21-11-18(5-6-20(21)29)36-24-19(4-3-7-31-24)22-23-25(34-13-32-22)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,36)(H,37,38)(H,32,33,34,35)
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n/an/a 126n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473607
PNG
(US10844062, Example 43)
Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H19F3N8O/c1-27(2,11-31)15-8-14(9-16(28)10-15)26(39)37-19-6-5-18(29)22(20(19)30)38-24-17(4-3-7-32-24)21-23-25(35-12-33-21)36-13-34-23/h3-10,12-13H,1-2H3,(H,32,38)(H,37,39)(H,33,34,35,36)
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n/an/a 127n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473609
PNG
(US10844062, Example 45)
Show SMILES Fc1ccc(NC(=O)c2cccc(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C23H14ClF2N7O/c24-13-4-1-3-12(9-13)23(34)32-16-7-6-15(25)19(17(16)26)33-21-14(5-2-8-27-21)18-20-22(30-10-28-18)31-11-29-20/h1-11H,(H,27,33)(H,32,34)(H,28,29,30,31)
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n/an/a 147n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473615
PNG
(US10844062, Example 51)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C24H16F3N7O/c25-24(26,27)15-5-1-4-14(10-15)23(35)34-17-7-2-6-16(11-17)33-21-18(8-3-9-28-21)19-20-22(31-12-29-19)32-13-30-20/h1-13H,(H,28,33)(H,34,35)(H,29,30,31,32)
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n/an/a 182n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473655
PNG
(US10844062, Example 135)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cc(Cl)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H14ClF4N7O/c25-14-7-12(6-13(8-14)24(27,28)29)23(37)36-18-9-15(3-4-17(18)26)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 184n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473588
PNG
(US10844062, Example 24)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl
Show InChI InChI=1S/C27H21ClN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)36-21-12-18(8-9-20(21)28)35-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 191n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473651
PNG
(US10844062, Example 87)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]ccc23)cc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H16F4N6O/c26-19-7-6-16(12-20(19)35-24(36)14-3-1-4-15(11-14)25(27,28)29)34-23-17(5-2-9-30-23)21-18-8-10-31-22(18)33-13-32-21/h1-13H,(H,30,34)(H,35,36)(H,31,32,33)
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n/an/a 210n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473591
PNG
(US10844062, Example 27)
Show SMILES Fc1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H14F5N7O/c25-15-7-8-16(35-23(37)12-3-5-13(6-4-12)24(27,28)29)17(26)19(15)36-21-14(2-1-9-30-21)18-20-22(33-10-31-18)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34)
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n/an/a 229n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473657
PNG
(US10844062, Example 154)
Show SMILES CC(C)(C#N)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C28H20F4N8O/c1-27(2,12-33)16-8-15(9-17(10-16)28(30,31)32)26(41)40-21-11-18(5-6-20(21)29)39-24-19(4-3-7-34-24)22-23-25(37-13-35-22)38-14-36-23/h3-11,13-14H,1-2H3,(H,34,39)(H,40,41)(H,35,36,37,38)
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n/an/a 253n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473636
PNG
(US10844062, Example 72)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)c1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H14F5N7O/c25-15-6-7-16(17(26)19(15)36-23(37)12-3-1-4-13(9-12)24(27,28)29)35-21-14(5-2-8-30-21)18-20-22(33-10-31-18)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 300n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473584
PNG
(US10844062, Example 20)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C2(CC2)C#N)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C27H18F2N8O/c28-18-6-7-19(36-26(38)15-3-1-4-16(11-15)27(12-30)8-9-27)20(29)22(18)37-24-17(5-2-10-31-24)21-23-25(34-13-32-21)35-14-33-23/h1-7,10-11,13-14H,8-9H2,(H,31,37)(H,36,38)(H,32,33,34,35)
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n/an/a 335n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473608
PNG
(US10844062, Example 44)
Show SMILES CC(C)(C#N)c1cc(cc(F)c1F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H18F4N8O/c1-27(2,10-32)15-8-13(9-17(29)19(15)30)26(40)38-18-6-5-16(28)22(20(18)31)39-24-14(4-3-7-33-24)21-23-25(36-11-34-21)37-12-35-23/h3-9,11-12H,1-2H3,(H,33,39)(H,38,40)(H,34,35,36,37)
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US Patent
n/an/a 340n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473610
PNG
(US10844062, Example 46)
Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C25H20F2N8O/c1-35(2)15-6-3-5-14(11-15)25(36)33-18-9-8-17(26)21(19(18)27)34-23-16(7-4-10-28-23)20-22-24(31-12-29-20)32-13-30-22/h3-13H,1-2H3,(H,28,34)(H,33,36)(H,29,30,31,32)
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n/an/a 347n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473647
PNG
(US10844062, Example 83)
Show SMILES CC(C)(C(N)=O)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C28H23F2N7O2/c1-28(2,27(31)39)16-6-3-5-15(13-16)26(38)36-20-9-8-19(29)23(21(20)30)37-25-17(7-4-11-32-25)22-18-10-12-33-24(18)35-14-34-22/h3-14H,1-2H3,(H2,31,39)(H,32,37)(H,36,38)(H,33,34,35)
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n/an/a 394n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473628
PNG
(US10844062, Example 64)
Show SMILES Cc1cccc(n1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C23H17FN8O/c1-13-4-2-6-17(30-13)23(33)32-18-10-14(7-8-16(18)24)31-21-15(5-3-9-25-21)19-20-22(28-11-26-19)29-12-27-20/h2-12H,1H3,(H,25,31)(H,32,33)(H,26,27,28,29)
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n/an/a 394n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473601
PNG
(US10844062, Example 37)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C#N)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H14F2N8O/c25-16-6-7-17(33-24(35)14-4-1-3-13(9-14)10-27)18(26)20(16)34-22-15(5-2-8-28-22)19-21-23(31-11-29-19)32-12-30-21/h1-9,11-12H,(H,28,34)(H,33,35)(H,29,30,31,32)
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n/an/a 526n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473612
PNG
(US10844062, Example 48)
Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C23H16ClN7O/c24-15-5-1-4-14(10-15)23(32)31-17-7-2-6-16(11-17)30-21-18(8-3-9-25-21)19-20-22(28-12-26-19)29-13-27-20/h1-13H,(H,25,30)(H,31,32)(H,26,27,28,29)
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n/an/a 590n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473598
PNG
(US10844062, Example 34)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C23H14F2N8O3/c24-15-6-7-16(31-23(34)12-3-1-4-13(9-12)33(35)36)17(25)19(15)32-21-14(5-2-8-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11H,(H,26,32)(H,31,34)(H,27,28,29,30)
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n/an/a 646n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473602
PNG
(US10844062, Example 38)
Show SMILES COc1ccc(cc1C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C25H16F5N7O2/c1-39-17-7-4-12(9-14(17)25(28,29)30)24(38)36-16-6-5-15(26)20(18(16)27)37-22-13(3-2-8-31-22)19-21-23(34-10-32-19)35-11-33-21/h2-11H,1H3,(H,31,37)(H,36,38)(H,32,33,34,35)
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n/an/a 760n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473632
PNG
(US10844062, Example 68)
Show SMILES Cc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F3N7O/c1-14-7-8-17(11-19(14)35-24(36)15-4-2-5-16(10-15)25(26,27)28)34-22-18(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 800n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473599
PNG
(US10844062, Example 35)
Show SMILES COc1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C24H17F2N7O2/c1-35-14-5-2-4-13(10-14)24(34)32-17-8-7-16(25)20(18(17)26)33-22-15(6-3-9-27-22)19-21-23(30-11-28-19)31-12-29-21/h2-12H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31)
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n/an/a 846n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473618
PNG
(US10844062, Example 54)
Show SMILES Nc1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C23H16F2N8O/c24-15-6-7-16(32-23(34)12-3-1-4-13(26)9-12)17(25)19(15)33-21-14(5-2-8-27-21)18-20-22(30-10-28-18)31-11-29-20/h1-11H,26H2,(H,27,33)(H,32,34)(H,28,29,30,31)
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n/an/a 887n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473616
PNG
(US10844062, Example 52)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C23H14F2N8O3/c24-15-7-8-16(31-23(34)12-3-5-13(6-4-12)33(35)36)17(25)19(15)32-21-14(2-1-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11H,(H,26,32)(H,31,34)(H,27,28,29,30)
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n/an/a 887n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473586
PNG
(US10844062, Example 22)
Show SMILES CC(C)(C(N)=O)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H22F2N8O2/c1-27(2,26(30)39)15-6-3-5-14(11-15)25(38)36-18-9-8-17(28)21(19(18)29)37-23-16(7-4-10-31-23)20-22-24(34-12-32-20)35-13-33-22/h3-13H,1-2H3,(H2,30,39)(H,31,37)(H,36,38)(H,32,33,34,35)
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n/an/a 925n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473633
PNG
(US10844062, Example 69)
Show SMILES COc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F3N7O2/c1-37-19-8-7-16(11-18(19)35-24(36)14-4-2-5-15(10-14)25(26,27)28)34-22-17(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 950n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473621
PNG
(US10844062, Example 57)
Show SMILES Fc1ccc(NC(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C23H15F2N7O/c24-15-8-9-16(31-23(33)13-5-2-1-3-6-13)17(25)19(15)32-21-14(7-4-10-26-21)18-20-22(29-11-27-18)30-12-28-20/h1-12H,(H,26,32)(H,31,33)(H,27,28,29,30)
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n/an/a 969n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473639
PNG
(US10844062, Example 75)
Show SMILES Fc1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H16F4N8O/c25-17-10-15(35-23(37)34-14-4-1-3-13(9-14)24(26,27)28)6-7-18(17)36-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,36)(H2,34,35,37)(H,30,31,32,33)
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n/an/a 982n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473643
PNG
(US10844062, Example 79)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1
Show InChI InChI=1S/C24H16F3N7O/c25-24(26,27)15-4-1-3-14(11-15)23(35)34-17-8-6-16(7-9-17)33-21-18(5-2-10-28-21)19-20-22(31-12-29-19)32-13-30-20/h1-13H,(H,28,33)(H,34,35)(H,29,30,31,32)
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n/an/a 982n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473626
PNG
(US10844062, Example 62)
Show SMILES [O-][N+](=O)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C24H14F4N8O3/c25-17-4-3-14(34-21-16(2-1-5-29-21)19-20-22(32-10-30-19)33-11-31-20)9-18(17)35-23(37)12-6-13(24(26,27)28)8-15(7-12)36(38)39/h1-11H,(H,29,34)(H,35,37)(H,30,31,32,33)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473627
PNG
(US10844062, Example 63)
Show SMILES COc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C25H17F4N7O2/c1-38-16-8-13(7-14(9-16)25(27,28)29)24(37)36-19-10-15(4-5-18(19)26)35-22-17(3-2-6-30-22)20-21-23(33-11-31-20)34-12-32-21/h2-12H,1H3,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473606
PNG
(US10844062, Example 42)
Show SMILES CC(C)(C#N)c1cccc(C(=O)Nc2ccc(F)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2F)c1Cl
Show InChI InChI=1S/C27H19ClF2N8O/c1-27(2,11-31)16-7-3-5-14(19(16)28)26(39)37-18-9-8-17(29)22(20(18)30)38-24-15(6-4-10-32-24)21-23-25(35-12-33-21)36-13-34-23/h3-10,12-13H,1-2H3,(H,32,38)(H,37,39)(H,33,34,35,36)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473603
PNG
(US10844062, Example 39 | US10844062, Example 82)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)c1
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)35-18-8-9-21(20(28)12-18)36-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,36)(H,35,37)(H,31,32,33,34)
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n/an/a 1.43E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473644
PNG
(US10844062, Example 80)
Show SMILES COc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F3N7O2/c1-37-19-11-16(7-8-18(19)35-24(36)14-4-2-5-15(10-14)25(26,27)28)34-22-17(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473634
PNG
(US10844062, Example 70)
Show SMILES COc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H18F3N7O2/c1-37-19-8-7-16(34-24(36)14-4-2-5-15(10-14)25(26,27)28)11-18(19)35-22-17(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,35)(H,34,36)(H,30,31,32,33)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473650
PNG
(US10844062, Example 86)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C28H22FN7O/c1-28(2,15-30)18-7-3-6-17(14-18)27(37)36-22-10-4-9-21(23(22)29)35-26-19(8-5-12-31-26)24-20-11-13-32-25(20)34-16-33-24/h3-14,16H,1-2H3,(H,31,35)(H,36,37)(H,32,33,34)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473582
PNG
(US10844062, Comparative Example 1 | US10844062, Ex...)
Show SMILES Fc1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C28H21F5N8O2/c29-19-3-4-20(39-27(42)15-10-16(28(31,32)33)12-17(11-15)41-6-8-43-9-7-41)21(30)23(19)40-25-18(2-1-5-34-25)22-24-26(37-13-35-22)38-14-36-24/h1-5,10-14H,6-9H2,(H,34,40)(H,39,42)(H,35,36,37,38)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50038493
PNG
(CHEMBL3354835 | US10844062, Example 71)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H18F3N7O/c1-14-7-8-17(34-24(36)15-4-2-5-16(10-15)25(26,27)28)11-19(14)35-22-18(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,35)(H,34,36)(H,30,31,32,33)
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US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473571
PNG
(US10844062, Example 7)
Show SMILES Fc1ccc(NC(=O)c2ccno2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C20H12F2N8O2/c21-11-3-4-12(29-20(31)13-5-7-28-32-13)14(22)16(11)30-18-10(2-1-6-23-18)15-17-19(26-8-24-15)27-9-25-17/h1-9H,(H,23,30)(H,29,31)(H,24,25,26,27)
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n/an/a 2.07E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473572
PNG
(US10844062, Example 8)
Show SMILES Fc1ccc(NC(=O)c2cncs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C20H12F2N8OS/c21-11-3-4-12(29-20(31)13-6-23-9-32-13)14(22)16(11)30-18-10(2-1-5-24-18)15-17-19(27-7-25-15)28-8-26-17/h1-9H,(H,24,30)(H,29,31)(H,25,26,27,28)
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n/an/a 2.36E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473617
PNG
(US10844062, Example 53)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C24H17F2N7O2/c1-35-14-6-4-13(5-7-14)24(34)32-17-9-8-16(25)20(18(17)26)33-22-15(3-2-10-27-22)19-21-23(30-11-28-19)31-12-29-21/h2-12H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473565
PNG
(US10844062, Example 6)
Show SMILES Fc1ccc(NC(=O)c2ccco2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C21H13F2N7O2/c22-12-5-6-13(29-21(31)14-4-2-8-32-14)15(23)17(12)30-19-11(3-1-7-24-19)16-18-20(27-9-25-16)28-10-26-18/h1-10H,(H,24,30)(H,29,31)(H,25,26,27,28)
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n/an/a 2.55E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473562
PNG
(US10844062, Example 4)
Show SMILES CC(C)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C20H17F2N7O/c1-10(2)20(30)28-13-6-5-12(21)16(14(13)22)29-18-11(4-3-7-23-18)15-17-19(26-8-24-15)27-9-25-17/h3-10H,1-2H3,(H,23,29)(H,28,30)(H,24,25,26,27)
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n/an/a 2.72E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473563
PNG
(US10844062, Example 5)
Show SMILES Fc1ccc(NC(=O)c2cccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C21H13F2N7OS/c22-12-5-6-13(29-21(31)14-4-2-8-32-14)15(23)17(12)30-19-11(3-1-7-24-19)16-18-20(27-9-25-16)28-10-26-18/h1-10H,(H,24,30)(H,29,31)(H,25,26,27,28)
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n/an/a 3.08E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473581
PNG
(US10844062, Example 17)
Show SMILES Fc1ccc(NC(=O)c2ccc3OCCOc3c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H17F2N7O3/c26-15-4-5-16(33-25(35)13-3-6-17-18(10-13)37-9-8-36-17)19(27)21(15)34-23-14(2-1-7-28-23)20-22-24(31-11-29-20)32-12-30-22/h1-7,10-12H,8-9H2,(H,28,34)(H,33,35)(H,29,30,31,32)
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n/an/a 3.37E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473576
PNG
(US10844062, Example 12)
Show SMILES OC1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C29H23F5N8O2/c30-20-3-4-21(40-28(44)15-10-16(29(32,33)34)12-17(11-15)42-8-5-18(43)6-9-42)22(31)24(20)41-26-19(2-1-7-35-26)23-25-27(38-13-36-23)39-14-37-25/h1-4,7,10-14,18,43H,5-6,8-9H2,(H,35,41)(H,40,44)(H,36,37,38,39)
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n/an/a 3.44E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473595
PNG
(US10844062, Example 31)
Show SMILES Fc1cc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H14F5N7O/c25-15-8-16(26)18(36-23(37)12-3-1-4-13(7-12)24(27,28)29)9-17(15)35-21-14(5-2-6-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473582
PNG
(US10844062, Comparative Example 1 | US10844062, Ex...)
Show SMILES Fc1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C28H21F5N8O2/c29-19-3-4-20(39-27(42)15-10-16(28(31,32)33)12-17(11-15)41-6-8-43-9-7-41)21(30)23(19)40-25-18(2-1-5-34-25)22-24-26(37-13-35-22)38-14-36-24/h1-5,10-14H,6-9H2,(H,34,40)(H,39,42)(H,35,36,37,38)
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US Patent
n/an/a 4.15E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473540
PNG
(US10844062, Example 2)
Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C28H18F5N9O/c1-14-10-42(13-39-14)17-8-15(7-16(9-17)28(31,32)33)27(43)40-20-5-4-19(29)23(21(20)30)41-25-18(3-2-6-34-25)22-24-26(37-11-35-22)38-12-36-24/h2-13H,1H3,(H,34,41)(H,40,43)(H,35,36,37,38)
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US Patent
n/an/a 4.70E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473574
PNG
(US10844062, Example 10)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C29H24F5N9O/c1-42-7-9-43(10-8-42)18-12-16(11-17(13-18)29(32,33)34)28(44)40-21-5-4-20(30)24(22(21)31)41-26-19(3-2-6-35-26)23-25-27(38-14-36-23)39-15-37-25/h2-6,11-15H,7-10H2,1H3,(H,35,41)(H,40,44)(H,36,37,38,39)
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US Patent
n/an/a 4.71E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473583
PNG
(US10844062, Example 19)
Show SMILES Fc1ccc(NC(=O)c2ccc(N3CCCC3)c(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C28H21F5N8O/c29-18-6-7-19(39-27(42)15-5-8-20(41-10-1-2-11-41)17(12-15)28(31,32)33)21(30)23(18)40-25-16(4-3-9-34-25)22-24-26(37-13-35-22)38-14-36-24/h3-9,12-14H,1-2,10-11H2,(H,34,40)(H,39,42)(H,35,36,37,38)
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US Patent
n/an/a 4.97E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473575
PNG
(US10844062, Example 11)
Show SMILES Fc1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)N2CCSCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C28H21F5N8OS/c29-19-3-4-20(39-27(42)15-10-16(28(31,32)33)12-17(11-15)41-6-8-43-9-7-41)21(30)23(19)40-25-18(2-1-5-34-25)22-24-26(37-13-35-22)38-14-36-24/h1-5,10-14H,6-9H2,(H,34,40)(H,39,42)(H,35,36,37,38)
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US Patent
n/an/a 4.98E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473578
PNG
(US10844062, Example 14)
Show SMILES Fc1ccc(NC(=O)c2ccc(N3CCSCC3)c(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C28H21F5N8OS/c29-18-4-5-19(39-27(42)15-3-6-20(17(12-15)28(31,32)33)41-8-10-43-11-9-41)21(30)23(18)40-25-16(2-1-7-34-25)22-24-26(37-13-35-22)38-14-36-24/h1-7,12-14H,8-11H2,(H,34,40)(H,39,42)(H,35,36,37,38)
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US Patent
n/an/a 4.98E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473603
PNG
(US10844062, Example 39 | US10844062, Example 82)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)c1
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)35-18-8-9-21(20(28)12-18)36-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,36)(H,35,37)(H,31,32,33,34)
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US Patent
n/an/a 5.03E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473580
PNG
(US10844062, Example 16)
Show SMILES Fc1ccc(NC(=O)c2ccc(Cl)c(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H13ClF5N7O/c25-14-4-3-11(8-13(14)24(28,29)30)23(38)36-16-6-5-15(26)19(17(16)27)37-21-12(2-1-7-31-21)18-20-22(34-9-32-18)35-10-33-20/h1-10H,(H,31,37)(H,36,38)(H,32,33,34,35)
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n/an/a 5.06E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473561
PNG
(US10844062, Example 3)
Show SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(F)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2F)CC1
Show InChI InChI=1S/C31H28F5N9O/c1-2-44-10-12-45(13-11-44)15-19-6-5-18(14-21(19)31(34,35)36)30(46)42-23-8-7-22(32)26(24(23)33)43-28-20(4-3-9-37-28)25-27-29(40-16-38-25)41-17-39-27/h3-9,14,16-17H,2,10-13,15H2,1H3,(H,37,43)(H,42,46)(H,38,39,40,41)
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US Patent
n/an/a 5.38E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473623
PNG
(US10844062, Example 59)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)Nc2ccc(F)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H19F5N10O/c1-14-10-43(13-39-14)17-8-15(28(31,32)33)7-16(9-17)40-27(44)41-20-5-4-19(29)23(21(20)30)42-25-18(3-2-6-34-25)22-24-26(37-11-35-22)38-12-36-24/h2-13H,1H3,(H,34,42)(H2,40,41,44)(H,35,36,37,38)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473590
PNG
(US10844062, Example 26)
Show SMILES Fc1ccc(NC(=O)c2ccccc2C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H14F5N7O/c25-15-7-8-16(35-23(37)12-4-1-2-6-14(12)24(27,28)29)17(26)19(15)36-21-13(5-3-9-30-21)18-20-22(33-10-31-18)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473579
PNG
(US10844062, Example 15)
Show SMILES CC1CCN(CC1)c1ccc(cc1C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C30H25F5N8O/c1-16-8-11-43(12-9-16)22-7-4-17(13-19(22)30(33,34)35)29(44)41-21-6-5-20(31)25(23(21)32)42-27-18(3-2-10-36-27)24-26-28(39-14-37-24)40-15-38-26/h2-7,10,13-16H,8-9,11-12H2,1H3,(H,36,42)(H,41,44)(H,37,38,39,40)
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n/an/a 6.05E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473577
PNG
(US10844062, Example 13)
Show SMILES CC1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C30H25F5N8O/c1-16-6-9-43(10-7-16)19-12-17(11-18(13-19)30(33,34)35)29(44)41-22-5-4-21(31)25(23(22)32)42-27-20(3-2-8-36-27)24-26-28(39-14-37-24)40-15-38-26/h2-5,8,11-16H,6-7,9-10H2,1H3,(H,36,42)(H,41,44)(H,37,38,39,40)
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n/an/a 6.05E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473624
PNG
(US10844062, Example 60)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(F)c(Nc4ncccc4-c4ncnc5[nH]cnc45)c3F)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C31H29F5N10O/c1-2-45-10-12-46(13-11-45)15-18-5-6-19(14-21(18)31(34,35)36)42-30(47)43-23-8-7-22(32)26(24(23)33)44-28-20(4-3-9-37-28)25-27-29(40-16-38-25)41-17-39-27/h3-9,14,16-17H,2,10-13,15H2,1H3,(H,37,44)(H2,42,43,47)(H,38,39,40,41)
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US Patent
n/an/a 6.06E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473589
PNG
(US10844062, Example 25)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1c(F)ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(11-16)26(38)37-22-18(28)8-9-19(20(22)29)36-24-17(7-4-10-31-24)21-23-25(34-13-32-21)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,36)(H,37,38)(H,32,33,34,35)
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n/an/a 8.50E+3n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473620
PNG
(US10844062, Example 56)
Show SMILES Fc1ccc(NC(=O)c2cnccn2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C21H13F2N9O/c22-12-3-4-13(31-21(33)14-8-24-6-7-25-14)15(23)17(12)32-19-11(2-1-5-26-19)16-18-20(29-9-27-16)30-10-28-18/h1-10H,(H,26,32)(H,31,33)(H,27,28,29,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473622
PNG
(US10844062, Example 58)
Show SMILES Fc1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H13F8N7O/c26-15-3-4-16(39-23(41)11-6-12(24(28,29)30)8-13(7-11)25(31,32)33)17(27)19(15)40-21-14(2-1-5-34-21)18-20-22(37-9-35-18)38-10-36-20/h1-10H,(H,34,40)(H,39,41)(H,35,36,37,38)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473619
PNG
(US10844062, Example 55)
Show SMILES COC(=O)Nc1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C25H18F2N8O3/c1-38-25(37)33-14-5-2-4-13(10-14)24(36)34-17-8-7-16(26)20(18(17)27)35-22-15(6-3-9-28-22)19-21-23(31-11-29-19)32-12-30-21/h2-12H,1H3,(H,28,35)(H,33,37)(H,34,36)(H,29,30,31,32)
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n/an/a 1.48E+4n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473625
PNG
(US10844062, Example 61)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H14ClF4N7O/c25-16-5-3-12(8-15(16)24(27,28)29)23(37)36-18-9-13(4-6-17(18)26)35-21-14(2-1-7-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
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US Patent
n/an/a 4.50E+4n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...


US Patent US10844062 (2020)

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