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Patent code US10844067

Compile Data Set for Download or QSAR

Found 255 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473678
PNG
(7-Isopropyl-5-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyrr...)
Show SMILES CC(C)n1cc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6/c1-9(2)22-7-11(13-14(17)19-8-20-16(13)22)12-6-10-4-3-5-18-15(10)21-12/h3-9H,1-2H3,(H,18,21)(H2,17,19,20)
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n/an/a 0.300n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473666
PNG
(1-tert-Butyl-3-{1H-pyrrolo[2,3-b]pyridin-2- yl}-1H...)
Show SMILES CC(C)(C)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H17N7/c1-16(2,3)23-15-11(13(17)19-8-20-15)12(22-23)10-7-9-5-4-6-18-14(9)21-10/h4-8H,1-3H3,(H,18,21)(H2,17,19,20)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473667
PNG
(1-tert-Butyl-3-{3-chloro-1H-pyrrolo[2,3- b]pyridin...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C16H16ClN7/c1-16(2,3)24-15-9(13(18)20-7-21-15)11(23-24)12-10(17)8-5-4-6-19-14(8)22-12/h4-7H,1-3H3,(H,19,22)(H2,18,20,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473702
PNG
(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473726
PNG
(3-[4-Amino-3-(3-chloro-1H-pyrrolo[2,3- b]pyridin-2...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CCC(O)C1
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473695
PNG
(1-(cis-4-Aminocyclohexyl)-3-(3-chloro-1H- pyrrolo[...)
Show SMILES N[C@H]1CCC(CC1)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473736
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CCCC1
Show InChI InChI=1S/C17H16ClN7/c18-12-10-6-3-7-20-16(10)23-14(12)13-11-15(19)21-8-22-17(11)25(24-13)9-4-1-2-5-9/h3,6-9H,1-2,4-5H2,(H,20,23)(H2,19,21,22)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473712
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Show SMILES CC(C)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C15H14ClN7/c1-7(2)23-15-9(13(17)19-6-20-15)11(22-23)12-10(16)8-4-3-5-18-14(8)21-12/h3-7H,1-2H3,(H,18,21)(H2,17,19,20)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473691
PNG
(3-(3-bromo-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(tert...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3ncccc3c2Br)c2c(N)ncnc12
Show InChI InChI=1S/C16H16BrN7/c1-16(2,3)24-15-9(13(18)20-7-21-15)11(23-24)12-10(17)8-5-4-6-19-14(8)22-12/h4-7H,1-3H3,(H,19,22)(H2,18,20,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473707
PNG
(1-(tert-Butyl)-3-(5-chloro-1H-pyrrolo[2,3- b]pyrid...)
Show SMILES CC(C)(C)n1nc(-c2cc3cc(Cl)cnc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16ClN7/c1-16(2,3)24-15-11(13(18)20-7-21-15)12(23-24)10-5-8-4-9(17)6-19-14(8)22-10/h4-7H,1-3H3,(H,19,22)(H2,18,20,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473725
PNG
(N-[trans-4-[4-Amino-3-(3-chloro-1H- pyrrolo[2,3-b]...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CC[C@@H](CC1)NC(=O)C1CC1
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473699
PNG
(1-Cyclobutyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyr...)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccnc4[nH]3)c12)C1CCC1
Show InChI InChI=1S/C16H15N7/c17-14-12-13(11-7-9-3-2-6-18-15(9)21-11)22-23(10-4-1-5-10)16(12)20-8-19-14/h2-3,6-8,10H,1,4-5H2,(H,18,21)(H2,17,19,20)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473730
PNG
(7-Chloro-1-isopropyl-3-(1H-pyrrolo[2,3- b]pyridin-...)
Show SMILES CC(C)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncc(Cl)c12
Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-14-10(17)7-20-15(18)12(14)13(22-23)11-6-9-4-3-5-19-16(9)21-11/h3-8H,1-2H3,(H2,18,20)(H,19,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473719
PNG
(1-(sec-Butyl)-3-(3-chloro-1H-pyrrolo[2,3- b]pyridi...)
Show SMILES CCC(C)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473690
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-isop...)
Show SMILES CC(C)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)nccc12
Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-10-5-7-19-15(18)11(10)13(22-23)14-12(17)9-4-3-6-20-16(9)21-14/h3-8H,1-2H3,(H2,18,19)(H,20,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473694
PNG
(1-Isopropyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyra...)
Show SMILES CC(C)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C15H15N7/c1-8(2)22-15-11(13(16)18-7-19-15)12(21-22)10-6-9-4-3-5-17-14(9)20-10/h3-8H,1-2H3,(H,17,20)(H2,16,18,19)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473723
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-cycl...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CCC1
Show InChI InChI=1S/C16H14ClN7/c17-11-9-5-2-6-19-15(9)22-13(11)12-10-14(18)20-7-21-16(10)24(23-12)8-3-1-4-8/h2,5-8H,1,3-4H2,(H,19,22)(H2,18,20,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473689
PNG
(1-Isopropyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)-1H-...)
Show SMILES CC(C)n1nc(-c2cc3cccnc3[nH]2)c2c(N)nccc12
Show InChI InChI=1S/C16H16N6/c1-9(2)22-12-5-7-18-15(17)13(12)14(21-22)11-8-10-4-3-6-19-16(10)20-11/h3-9H,1-2H3,(H2,17,18)(H,19,20)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473676
PNG
((2-(4-Amino-1-(tert-butyl)-1H- pyrazolo[3,4-d]pyri...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3cc(CO)ccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C18H19ClN6O/c1-18(2,3)25-17-12(16(20)21-8-22-17)14(24-25)15-13(19)10-5-4-9(7-26)6-11(10)23-15/h4-6,8,23,26H,7H2,1-3H3,(H2,20,21,22)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473697
PNG
(3-[4-Amino-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyraz...)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccnc4[nH]3)c12)C1CCC(O)C1
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n/an/a 4n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473745
PNG
(2-(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4- d]pyrim...)
Show SMILES CC(C)(C)n1nc(-c2cc3ccc(nc3[nH]2)C#N)c2c(N)ncnc12
Show InChI InChI=1S/C17H16N8/c1-17(2,3)25-16-12(14(19)20-8-21-16)13(24-25)11-6-9-4-5-10(7-18)22-15(9)23-11/h4-6,8H,1-3H3,(H,22,23)(H2,19,20,21)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473680
PNG
(3-{3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl}- 1-(1-m...)
Show SMILES CS(=O)(=O)N1CCC(CC1)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C18H19ClN8O2S/c1-30(28,29)26-7-4-10(5-8-26)27-18-12(16(20)22-9-23-18)14(25-27)15-13(19)11-3-2-6-21-17(11)24-15/h2-3,6,9-10H,4-5,7-8H2,1H3,(H,21,24)(H2,20,22,23)
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n/an/a 4.30n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473703
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-ethy...)
Show SMILES CCn1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C14H12ClN7/c1-2-22-14-8(12(16)18-6-19-14)10(21-22)11-9(15)7-4-3-5-17-13(7)20-11/h3-6H,2H2,1H3,(H,17,20)(H2,16,18,19)
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n/an/a 4.40n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473735
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(tet...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CCOC1
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473704
PNG
(5-(1H-Indol-2-yl)-7-isopropyl-pyrrolo[2,3- d]pyrim...)
Show SMILES CC(C)n1cc(-c2cc3ccccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C17H17N5/c1-10(2)22-8-12(15-16(18)19-9-20-17(15)22)14-7-11-5-3-4-6-13(11)21-14/h3-10,21H,1-2H3,(H2,18,19,20)
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n/an/a 5n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473693
PNG
(N-(trans-4-(4-Amino-3-(1H-pyrrolo[2,3- b]pyridin-2...)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccnc4[nH]3)c12)C1CC[C@@H](CC1)NC(=O)C1CC1
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n/an/a 6.40n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473686
PNG
(US10844067, Example 29 | US10844067, Example 30 | ...)
Show SMILES CC(C)(C)OC(=O)N[C@H]1CCC(CC1)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
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n/an/a 6.80n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473675
PNG
(2-(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4- d]pyrim...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C#N)c2c(N)ncnc12
Show InChI InChI=1S/C18H16ClN7/c1-18(2,3)26-17-12(16(21)22-8-23-17)14(25-26)15-13(19)10-5-4-9(7-20)6-11(10)24-15/h4-6,8,24H,1-3H3,(H2,21,22,23)
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n/an/a 6.90n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473718
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(2,2...)
Show SMILES Nc1ncnc2n(CC(F)(F)F)nc(-c3[nH]c4ncccc4c3Cl)c12
Show InChI InChI=1S/C14H9ClF3N7/c15-8-6-2-1-3-20-12(6)23-10(8)9-7-11(19)21-5-22-13(7)25(24-9)4-14(16,17)18/h1-3,5H,4H2,(H,20,23)(H2,19,21,22)
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n/an/a 8n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM473667
PNG
(1-tert-Butyl-3-{3-chloro-1H-pyrrolo[2,3- b]pyridin...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C16H16ClN7/c1-16(2,3)24-15-9(13(18)20-7-21-15)11(23-24)12-10(17)8-5-4-6-19-14(8)22-12/h4-7H,1-3H3,(H,19,22)(H2,18,20,21)
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n/an/a 8.44n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473670
PNG
(5-(1H-Indol-2-yl)-7-(propan-2- yl)pyrrolo[2,1-f][1...)
Show SMILES CC(C)c1cc(-c2cc3ccccc3[nH]2)c2c(N)ncnn12
Show InChI InChI=1S/C17H17N5/c1-10(2)15-8-12(16-17(18)19-9-20-22(15)16)14-7-11-5-3-4-6-13(11)21-14/h3-10,21H,1-2H3,(H2,18,19,20)
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n/an/a 8.60n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473713
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-(tet...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CCOCC1
Show InChI InChI=1S/C17H16ClN7O/c18-12-10-2-1-5-20-16(10)23-14(12)13-11-15(19)21-8-22-17(11)25(24-13)9-3-6-26-7-4-9/h1-2,5,8-9H,3-4,6-7H2,(H,20,23)(H2,19,21,22)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473679
PNG
(1-(1-Methanesulfonylpiperidin-4-yl)-3-{1H- pyrrolo...)
Show SMILES CS(=O)(=O)N1CCC(CC1)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C18H20N8O2S/c1-29(27,28)25-7-4-12(5-8-25)26-18-14(16(19)21-10-22-18)15(24-26)13-9-11-3-2-6-20-17(11)23-13/h2-3,6,9-10,12H,4-5,7-8H2,1H3,(H,20,23)(H2,19,21,22)
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n/an/a 9n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473686
PNG
(US10844067, Example 29 | US10844067, Example 30 | ...)
Show SMILES CC(C)(C)OC(=O)N[C@H]1CCC(CC1)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
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n/an/a 10.3n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473739
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-prop...)
Show SMILES CCCn1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C15H14ClN7/c1-2-6-23-15-9(13(17)19-7-20-15)11(22-23)12-10(16)8-4-3-5-18-14(8)21-12/h3-5,7H,2,6H2,1H3,(H,18,21)(H2,17,19,20)
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n/an/a 11.9n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473684
PNG
(US10844067, Example 27 | US10844067, Example 28 | ...)
Show SMILES CC(C)(C)OC(=O)N[C@H]1CCC(CC1)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50389730
PNG
(CHEMBL2069946 | US10172858, Table 2.7 | US10544104...)
Show SMILES CC(C)n1nc(-c2cc3ccccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6/c1-9(2)22-16-13(15(17)18-8-19-16)14(21-22)12-7-10-5-3-4-6-11(10)20-12/h3-9,20H,1-2H3,(H2,17,18,19)
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n/an/a 18.7n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM473726
PNG
(3-[4-Amino-3-(3-chloro-1H-pyrrolo[2,3- b]pyridin-2...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ncccc4c3Cl)c12)C1CCC(O)C1
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n/an/a 19.1n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473708
PNG
(1-(tert-Butyl)-3-(3,5-dichloro-1H- pyrrolo[2,3-b]p...)
Show SMILES CC(C)(C)n1nc(-c2[nH]c3ncc(Cl)cc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C16H15Cl2N7/c1-16(2,3)25-15-9(13(19)21-6-22-15)11(24-25)12-10(18)8-4-7(17)5-20-14(8)23-12/h4-6H,1-3H3,(H,20,23)(H2,19,21,22)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473700
PNG
(1-Ethyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyrazolo...)
Show SMILES CCn1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C14H13N7/c1-2-21-14-10(12(15)17-7-18-14)11(20-21)9-6-8-4-3-5-16-13(8)19-9/h3-7H,2H2,1H3,(H,16,19)(H2,15,17,18)
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n/an/a 21n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473683
PNG
(1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-ind...)
Show SMILES COCc1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H21ClN6O/c1-19(2,3)26-18-13(17(21)22-9-23-18)15(25-26)16-14(20)11-6-5-10(8-27-4)7-12(11)24-16/h5-7,9,24H,8H2,1-4H3,(H2,21,22,23)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473698
PNG
(1-Cyclohexyl-3-(1H-pyrrolo[2,3-b]pyridin- 2-yl)pyr...)
Show SMILES Nc1ncnc2n(nc(-c3cc4cccnc4[nH]3)c12)C1CCCCC1
Show InChI InChI=1S/C18H19N7/c19-16-14-15(13-9-11-5-4-8-20-17(11)23-13)24-25(18(14)22-10-21-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7H2,(H,20,23)(H2,19,21,22)
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473717
PNG
(3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 1-((te...)
Show SMILES Nc1ncnc2n(CC3CCCCO3)nc(-c3[nH]c4ncccc4c3Cl)c12
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Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM473695
PNG
(1-(cis-4-Aminocyclohexyl)-3-(3-chloro-1H- pyrrolo[...)
Show SMILES N[C@H]1CCC(CC1)n1nc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
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n/an/a 24.4n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM473678
PNG
(7-Isopropyl-5-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyrr...)
Show SMILES CC(C)n1cc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6/c1-9(2)22-7-11(13-14(17)19-8-20-16(13)22)12-6-10-4-3-5-18-15(10)21-12/h3-9H,1-2H3,(H,18,21)(H2,17,19,20)
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n/an/a 25n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473664
PNG
(3-(3-Chloro-1H-indol-2-yl)-1-(trans-4- morpholinoc...)
Show SMILES Nc1ncnc2n(nc(-c3[nH]c4ccccc4c3Cl)c12)C1CC[C@@H](CC1)N1CCOCC1
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n/an/a 25.3n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473684
PNG
(US10844067, Example 27 | US10844067, Example 28 | ...)
Show SMILES CC(C)(C)OC(=O)N[C@H]1CCC(CC1)n1nc(-c2cc3cccnc3[nH]2)c2c(N)ncnc12
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n/an/a 26.1n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM473702
PNG
(5-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)- 7-isop...)
Show SMILES CC(C)n1cc(-c2[nH]c3ncccc3c2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-6-10(11-14(18)20-7-21-16(11)23)13-12(17)9-4-3-5-19-15(9)22-13/h3-8H,1-2H3,(H,19,22)(H2,18,20,21)
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n/an/a 26.1n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473663
PNG
(3-(1H-Indol-2-yl)-1-(trans-4- morpholinocyclohexyl...)
Show SMILES Nc1ncnc2n(nc(-c3cc4ccccc4[nH]3)c12)C1CC[C@@H](CC1)N1CCOCC1
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n/an/a 26.5n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM473662
PNG
(N-(trans-4-(4-Amino-3-(1H-indol-2-yl)-1H- pyrazolo...)
Show SMILES Nc1ncnc2n(nc(-c3cc4ccccc4[nH]3)c12)C1CC[C@@H](CC1)NC(=O)C1CC1
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n/an/a 28.5n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...


US Patent US10844067 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%