BindingDB logo
myBDB logout

Patent code US10849883

Compile Data Set for Download or QSAR

Found 380 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor D


(Homo sapiens (Human))
BDBM474672
PNG
(US10849883, Compound 98b)
Show SMILES CC(C1CC1)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H25ClFN5O3/c1-14(15-9-10-15)30(12-20(32)28-11-16-5-4-7-18(25)22(16)26)21(33)13-31-19-8-3-2-6-17(19)23(29-31)24(27)34/h2-8,14-15H,9-13H2,1H3,(H2,27,34)(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474680
PNG
(US10849883, Compound 106a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)-c1ccnc(F)c1
Show InChI InChI=1S/C29H27ClF2N4O3/c1-17(2)36(15-27(38)34-13-21-5-4-6-24(30)29(21)32)28(39)16-35-14-23(18(3)37)22-11-19(7-8-25(22)35)20-9-10-33-26(31)12-20/h4-12,14,17H,13,15-16H2,1-3H3,(H,34,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474692
PNG
(US10849883, Compound 118b)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Br)n1)C(=O)Cn1cc(C(C)=O)c2cc(Nc3cncnc3)ccc12
Show InChI InChI=1S/C27H28BrN7O3/c1-17(2)35(14-26(37)31-12-20-5-4-6-25(28)33-20)27(38)15-34-13-23(18(3)36)22-9-19(7-8-24(22)34)32-21-10-29-16-30-11-21/h4-11,13,16-17,32H,12,14-15H2,1-3H3,(H,31,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474706
PNG
(US10849883, Compound 130a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)C#Cc1ccccn1
Show InChI InChI=1S/C31H28ClFN4O3/c1-20(2)37(18-29(39)35-16-23-7-6-9-27(32)31(23)33)30(40)19-36-17-26(21(3)38)25-15-22(11-13-28(25)36)10-12-24-8-4-5-14-34-24/h4-9,11,13-15,17,20H,16,18-19H2,1-3H3,(H,35,39)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474708
PNG
(US10849883, Compound 132g)
Show SMILES COC(=O)c1ccc2n(CC(=O)N(CC(=O)NCc3cccc(Cl)c3F)C(C)C)nc(C(N)=O)c2c1
Show InChI InChI=1S/C24H25ClFN5O5/c1-13(2)30(11-19(32)28-10-15-5-4-6-17(25)21(15)26)20(33)12-31-18-8-7-14(24(35)36-3)9-16(18)22(29-31)23(27)34/h4-9,13H,10-12H2,1-3H3,(H2,27,34)(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474733
PNG
(US10849883, Compound 129b)
Show SMILES COC(=O)c1ccc2n(CC(=O)N(CC(=O)NCc3cccc(Cl)c3F)C(C)C)cc(C(C)=O)c2c1
Show InChI InChI=1S/C26H27ClFN3O5/c1-15(2)31(13-23(33)29-11-18-6-5-7-21(27)25(18)28)24(34)14-30-12-20(16(3)32)19-10-17(26(35)36-4)8-9-22(19)30/h5-10,12,15H,11,13-14H2,1-4H3,(H,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474735
PNG
(US10849883, Compound 164a)
Show SMILES CC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(cc12)C#Cc1ncccn1
Show InChI InChI=1S/C29H24ClFN6O3/c1-18(38)29-22-14-19(7-11-25-32-12-3-13-33-25)6-10-24(22)37(35-29)17-27(40)36(21-8-9-21)16-26(39)34-15-20-4-2-5-23(30)28(20)31/h2-6,10,12-14,21H,8-9,15-17H2,1H3,(H,34,39)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474738
PNG
(US10849883, Compound 165c)
Show SMILES CC(=O)c1cn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(cc12)C(=O)NCc1ccccn1
Show InChI InChI=1S/C31H29ClFN5O4/c1-19(39)25-16-37(27-11-8-20(13-24(25)27)31(42)36-15-22-6-2-3-12-34-22)18-29(41)38(23-9-10-23)17-28(40)35-14-21-5-4-7-26(32)30(21)33/h2-8,11-13,16,23H,9-10,14-15,17-18H2,1H3,(H,35,40)(H,36,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474758
PNG
(US10849883, Compound 183a)
Show SMILES CC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)[C@H]2C[C@H](O)C2)c2ccccc12
Show InChI InChI=1S/C24H24ClFN4O4/c1-14(31)24-18-6-2-3-8-20(18)30(28-24)13-22(34)29(16-9-17(32)10-16)12-21(33)27-11-15-5-4-7-19(25)23(15)26/h2-8,16-17,32H,9-13H2,1H3,(H,27,33)/t16-,17-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474761
PNG
(US10849883, Compound 186b)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)[C@@H]2CCOC2)c2ccccc12
Show InChI InChI=1S/C23H23ClFN5O4/c24-17-6-3-4-14(21(17)25)10-27-19(31)11-29(15-8-9-34-13-15)20(32)12-30-18-7-2-1-5-16(18)22(28-30)23(26)33/h1-7,15H,8-13H2,(H2,26,33)(H,27,31)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474764
PNG
(US10849883, Compound 191a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2cc(ccc12)C(=O)NCc1ccccn1
Show InChI InChI=1S/C29H29ClFN7O4/c1-17(2)37(15-24(39)34-13-19-6-5-8-22(30)26(19)31)25(40)16-38-23-10-9-18(12-21(23)27(36-38)28(32)41)29(42)35-14-20-7-3-4-11-33-20/h3-12,17H,13-16H2,1-2H3,(H2,32,41)(H,34,39)(H,35,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474769
PNG
(US10849883, Compound 196a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2cc(ccc12)C(=O)NCc1cccnc1
Show InChI InChI=1S/C29H29ClFN7O4/c1-17(2)37(15-24(39)34-14-20-6-3-7-22(30)26(20)31)25(40)16-38-23-9-8-19(11-21(23)27(36-38)28(32)41)29(42)35-13-18-5-4-10-33-12-18/h3-12,17H,13-16H2,1-2H3,(H2,32,41)(H,34,39)(H,35,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474784
PNG
(US10849883, Compound 215a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2cc(NC(=O)Nc3cncnc3)ccc12
Show InChI InChI=1S/C27H27ClFN9O4/c1-15(2)37(12-22(39)33-9-16-4-3-5-20(28)24(16)29)23(40)13-38-21-7-6-17(8-19(21)25(36-38)26(30)41)34-27(42)35-18-10-31-14-32-11-18/h3-8,10-11,14-15H,9,12-13H2,1-2H3,(H2,30,41)(H,33,39)(H2,34,35,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474786
PNG
(US10849883, Compound 218a)
Show SMILES CN(C)c1ncc(cn1)-c1ccc2n(CC(=O)N(CC(=O)NCc3cccc(Cl)c3F)C3CC3)nc(C(N)=O)c2c1
Show InChI InChI=1S/C28H28ClFN8O3/c1-36(2)28-33-12-18(13-34-28)16-6-9-22-20(10-16)26(27(31)41)35-38(22)15-24(40)37(19-7-8-19)14-23(39)32-11-17-4-3-5-21(29)25(17)30/h3-6,9-10,12-13,19H,7-8,11,14-15H2,1-2H3,(H2,31,41)(H,32,39)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474804
PNG
(US10849883, Compound 236b)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2cc(NC(=O)N3CCCC(F)(F)C3)ccc12
Show InChI InChI=1S/C28H29ClF3N7O4/c29-20-4-1-3-16(24(20)30)12-34-22(40)13-38(18-6-7-18)23(41)14-39-21-11-17(5-8-19(21)25(36-39)26(33)42)35-27(43)37-10-2-9-28(31,32)15-37/h1,3-5,8,11,18H,2,6-7,9-10,12-15H2,(H2,33,42)(H,34,40)(H,35,43)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474825
PNG
(US10849883, Compound 251a)
Show SMILES CC(=O)c1cn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2cc(N)ccc12
Show InChI InChI=1S/C24H24ClFN4O3/c1-14(31)19-11-29(21-9-16(27)5-8-18(19)21)13-23(33)30(17-6-7-17)12-22(32)28-10-15-3-2-4-20(25)24(15)26/h2-5,8-9,11,17H,6-7,10,12-13,27H2,1H3,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474838
PNG
(US10849883, Compound 188a)
Show SMILES CC(C)N(CC(=O)Nc1cccc(Br)n1)C(=O)Cn1nc(C(C)=O)c2cc(Nc3cccnc3)ccc12
Show InChI InChI=1S/C26H26BrN7O3/c1-16(2)33(14-24(36)31-23-8-4-7-22(27)30-23)25(37)15-34-21-10-9-18(29-19-6-5-11-28-13-19)12-20(21)26(32-34)17(3)35/h4-13,16,29H,14-15H2,1-3H3,(H,30,31,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474841
PNG
(US10849883, Compound 254a)
Show SMILES COC(=O)c1ccc2n(CC(=O)N(CC(=O)Nc3cccc(Br)n3)C(C)C)nc(C(N)=O)c2c1
Show InChI InChI=1S/C22H23BrN6O5/c1-12(2)28(10-18(30)26-17-6-4-5-16(23)25-17)19(31)11-29-15-8-7-13(22(33)34-3)9-14(15)20(27-29)21(24)32/h4-9,12H,10-11H2,1-3H3,(H2,24,32)(H,25,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474847
PNG
(US10849883, Compound 269a)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(NC(=O)CC3CC3)cc12
Show InChI InChI=1S/C27H28ClFN6O4/c28-20-3-1-2-16(25(20)29)12-31-23(37)13-34(18-7-8-18)24(38)14-35-21-9-6-17(32-22(36)10-15-4-5-15)11-19(21)26(33-35)27(30)39/h1-3,6,9,11,15,18H,4-5,7-8,10,12-14H2,(H2,30,39)(H,31,37)(H,32,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474854
PNG
(US10849883, Compound 283a)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)Nc2cccc(c2F)-c2ccccc2Cl)C2CC2)c2ccccc12
Show InChI InChI=1S/C27H23ClFN5O3/c28-20-9-3-1-6-17(20)18-8-5-10-21(25(18)29)31-23(35)14-33(16-12-13-16)24(36)15-34-22-11-4-2-7-19(22)26(32-34)27(30)37/h1-11,16H,12-15H2,(H2,30,37)(H,31,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474870
PNG
(US10849883, Compound 294a)
Show SMILES CC(C)(C)OC(=O)N[C@H]1CCCN(C1)C(=O)Nc1ccc2n(CC(=O)N(CC(=O)NCc3cccc(Cl)c3F)C3CC3)nc(C(N)=O)c2c1
Show InChI InChI=1S/C33H40ClFN8O6/c1-33(2,3)49-32(48)39-21-7-5-13-41(16-21)31(47)38-20-9-12-25-23(14-20)29(30(36)46)40-43(25)18-27(45)42(22-10-11-22)17-26(44)37-15-19-6-4-8-24(34)28(19)35/h4,6,8-9,12,14,21-22H,5,7,10-11,13,15-18H2,1-3H3,(H2,36,46)(H,37,44)(H,38,47)(H,39,48)/t21-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474874
PNG
(US10849883, Compound 296f)
Show SMILES C[C@H](NC(=O)CN(C1CC1)C(=O)Cn1nc(C(N)=O)c2ccncc12)c1cccc(Cl)c1F
Show InChI InChI=1S/C22H22ClFN6O3/c1-12(14-3-2-4-16(23)20(14)24)27-18(31)10-29(13-5-6-13)19(32)11-30-17-9-26-8-7-15(17)21(28-30)22(25)33/h2-4,7-9,12-13H,5-6,10-11H2,1H3,(H2,25,33)(H,27,31)/t12-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474880
PNG
(US10849883, Compound 302d)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(C)=O)c2cc(NC(=O)CC(C)(C)C)ccc12
Show InChI InChI=1S/C29H35ClFN5O4/c1-17(2)35(15-25(39)32-14-19-8-7-9-22(30)27(19)31)26(40)16-36-23-11-10-20(33-24(38)13-29(4,5)6)12-21(23)28(34-36)18(3)37/h7-12,17H,13-16H2,1-6H3,(H,32,39)(H,33,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474886
PNG
(US10849883, Compound 308e)
Show SMILES CC(=O)c1cn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2cnc(Nc3cncnc3)cc12
Show InChI InChI=1S/C27H25ClFN7O3/c1-16(37)21-12-35(23-11-32-24(7-20(21)23)34-18-9-30-15-31-10-18)14-26(39)36(19-5-6-19)13-25(38)33-8-17-3-2-4-22(28)27(17)29/h2-4,7,9-12,15,19H,5-6,8,13-14H2,1H3,(H,32,34)(H,33,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474890
PNG
(US10849883, Compound 312a)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(NCC3CCCCC3)cc12
Show InChI InChI=1S/C29H34ClFN6O3/c30-23-8-4-7-19(27(23)31)15-34-25(38)16-36(21-10-11-21)26(39)17-37-24-12-9-20(13-22(24)28(35-37)29(32)40)33-14-18-5-2-1-3-6-18/h4,7-9,12-13,18,21,33H,1-3,5-6,10-11,14-17H2,(H2,32,40)(H,34,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474899
PNG
(US10849883, Compound 321a)
Show SMILES CN1CCC(CC1)C(=O)Nc1ccc2n(CC(=O)N(CC(=O)NCc3cccc(Cl)c3F)C3CC3)nc(C(N)=O)c2c1
Show InChI InChI=1S/C29H33ClFN7O4/c1-36-11-9-17(10-12-36)29(42)34-19-5-8-23-21(13-19)27(28(32)41)35-38(23)16-25(40)37(20-6-7-20)15-24(39)33-14-18-3-2-4-22(30)26(18)31/h2-5,8,13,17,20H,6-7,9-12,14-16H2,1H3,(H2,32,41)(H,33,39)(H,34,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474901
PNG
(US10849883, Compound 323a)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2cc(NC(=O)CC3CC3)ccc12
Show InChI InChI=1S/C27H28ClFN6O4/c28-20-3-1-2-16(25(20)29)12-31-23(37)13-34(18-7-8-18)24(38)14-35-21-11-17(32-22(36)10-15-4-5-15)6-9-19(21)26(33-35)27(30)39/h1-3,6,9,11,15,18H,4-5,7-8,10,12-14H2,(H2,30,39)(H,31,37)(H,32,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474903
PNG
(US10849883, Compound 325b)
Show SMILES CC(=O)c1cn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(NC(=O)c3cccc(N)c3)cc12
Show InChI InChI=1S/C31H29ClFN5O4/c1-18(39)25-15-37(27-11-8-22(13-24(25)27)36-31(42)19-4-2-6-21(34)12-19)17-29(41)38(23-9-10-23)16-28(40)35-14-20-5-3-7-26(32)30(20)33/h2-8,11-13,15,23H,9-10,14,16-17,34H2,1H3,(H,35,40)(H,36,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474581
PNG
(US10849883, Compound 10c)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccccc12
Show InChI InChI=1S/C22H21ClFN5O3/c23-16-6-3-4-13(20(16)24)10-26-18(30)11-28(14-8-9-14)19(31)12-29-17-7-2-1-5-15(17)21(27-29)22(25)32/h1-7,14H,8-12H2,(H2,25,32)(H,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474619
PNG
(US10849883, Compound 48b)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CCCC2)c2ccccc12
Show InChI InChI=1S/C24H25ClFN5O3/c25-18-10-5-6-15(22(18)26)12-28-20(32)13-30(16-7-1-2-8-16)21(33)14-31-19-11-4-3-9-17(19)23(29-31)24(27)34/h3-6,9-11,16H,1-2,7-8,12-14H2,(H2,27,34)(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474674
PNG
(US10849883, Compound 100a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)-c1ccn(C)n1
Show InChI InChI=1S/C28H29ClFN5O3/c1-17(2)35(15-26(37)31-13-20-6-5-7-23(29)28(20)30)27(38)16-34-14-22(18(3)36)21-12-19(8-9-25(21)34)24-10-11-33(4)32-24/h5-12,14,17H,13,15-16H2,1-4H3,(H,31,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474682
PNG
(US10849883, Compound 108a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)-c1cncnc1
Show InChI InChI=1S/C28H27ClFN5O3/c1-17(2)35(14-26(37)33-12-20-5-4-6-24(29)28(20)30)27(38)15-34-13-23(18(3)36)22-9-19(7-8-25(22)34)21-10-31-16-32-11-21/h4-11,13,16-17H,12,14-15H2,1-3H3,(H,33,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474686
PNG
(US10849883, Compound 112a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)C#Cc1cncnc1
Show InChI InChI=1S/C30H27ClFN5O3/c1-19(2)37(16-28(39)35-14-23-5-4-6-26(31)30(23)32)29(40)17-36-15-25(20(3)38)24-11-21(9-10-27(24)36)7-8-22-12-33-18-34-13-22/h4-6,9-13,15,18-19H,14,16-17H2,1-3H3,(H,35,39)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474690
PNG
(US10849883, Compound 116a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)C#Cc1ncccn1
Show InChI InChI=1S/C30H27ClFN5O3/c1-19(2)37(17-28(39)35-15-22-6-4-7-25(31)30(22)32)29(40)18-36-16-24(20(3)38)23-14-21(8-10-26(23)36)9-11-27-33-12-5-13-34-27/h4-8,10,12-14,16,19H,15,17-18H2,1-3H3,(H,35,39)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474695
PNG
(US10849883, Compound 121b)
Show SMILES CC(C)CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H29ClFN5O3/c1-15(2)11-16(3)31(13-21(33)29-12-17-7-6-9-19(26)23(17)27)22(34)14-32-20-10-5-4-8-18(20)24(30-32)25(28)35/h4-10,15-16H,11-14H2,1-3H3,(H2,28,35)(H,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474722
PNG
(US10849883, Compound 148a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2cc(NC(=O)N3CCCC(F)(F)C3)ccc12
Show InChI InChI=1S/C28H31ClF3N7O4/c1-16(2)38(13-22(40)34-12-17-5-3-6-20(29)24(17)30)23(41)14-39-21-8-7-18(11-19(21)25(36-39)26(33)42)35-27(43)37-10-4-9-28(31,32)15-37/h3,5-8,11,16H,4,9-10,12-15H2,1-2H3,(H2,33,42)(H,34,40)(H,35,43)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474727
PNG
(US10849883, Compound 155d)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C23H24ClFN4O3/c1-14(2)28(12-20(31)26-11-16-7-6-9-18(24)22(16)25)21(32)13-29-19-10-5-4-8-17(19)23(27-29)15(3)30/h4-10,14H,11-13H2,1-3H3,(H,26,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474737
PNG
(US10849883, Compound 163a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)C(=O)NCc1cccnc1
Show InChI InChI=1S/C31H31ClFN5O4/c1-19(2)38(17-28(40)35-15-23-7-4-8-26(32)30(23)33)29(41)18-37-16-25(20(3)39)24-12-22(9-10-27(24)37)31(42)36-14-21-6-5-11-34-13-21/h4-13,16,19H,14-15,17-18H2,1-3H3,(H,35,40)(H,36,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474739
PNG
(US10849883, Compound 166a)
Show SMILES CC(=O)c1cn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(cc12)C(=O)NCc1ccncc1
Show InChI InChI=1S/C31H29ClFN5O4/c1-19(39)25-16-37(27-8-5-21(13-24(25)27)31(42)36-14-20-9-11-34-12-10-20)18-29(41)38(23-6-7-23)17-28(40)35-15-22-3-2-4-26(32)30(22)33/h2-5,8-13,16,23H,6-7,14-15,17-18H2,1H3,(H,35,40)(H,36,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474746
PNG
(US10849883, Compound 172b)
Show SMILES NC(=O)c1nn(CC(=O)N(C[C@H]2C[C@H](O)C2)CC(=O)NCc2cccc(Cl)c2F)c2ccccc12
Show InChI InChI=1S/C24H25ClFN5O4/c25-18-6-3-4-15(22(18)26)10-28-20(33)12-30(11-14-8-16(32)9-14)21(34)13-31-19-7-2-1-5-17(19)23(29-31)24(27)35/h1-7,14,16,32H,8-13H2,(H2,27,35)(H,28,33)/t14-,16-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474747
PNG
(US10849883, Compound 158a)
Show SMILES CC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(Br)cc12
Show InChI InChI=1S/C23H21BrClFN4O3/c1-13(31)23-17-9-15(24)5-8-19(17)30(28-23)12-21(33)29(16-6-7-16)11-20(32)27-10-14-3-2-4-18(25)22(14)26/h2-5,8-9,16H,6-7,10-12H2,1H3,(H,27,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474766
PNG
(US10849883, Compound 193a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(C)=O)c2cc(ccc12)-c1cnc(nc1)N(C)C
Show InChI InChI=1S/C29H31ClFN7O3/c1-17(2)37(15-25(40)32-12-20-7-6-8-23(30)27(20)31)26(41)16-38-24-10-9-19(11-22(24)28(35-38)18(3)39)21-13-33-29(34-14-21)36(4)5/h6-11,13-14,17H,12,15-16H2,1-5H3,(H,32,40)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474772
PNG
(US10849883, Compound 202e)
Show SMILES CC(=O)c1cn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2cc(Br)ccc12
Show InChI InChI=1S/C24H22BrClFN3O3/c1-14(31)19-11-29(21-9-16(25)5-8-18(19)21)13-23(33)30(17-6-7-17)12-22(32)28-10-15-3-2-4-20(26)24(15)27/h2-5,8-9,11,17H,6-7,10,12-13H2,1H3,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474779
PNG
(US10849883, Compound 209b)
Show SMILES CC(=O)c1cn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(NC(=O)N3CCCC(F)(F)C3)cc12
Show InChI InChI=1S/C30H31ClF3N5O4/c1-18(40)23-14-38(25-9-6-20(12-22(23)25)36-29(43)37-11-3-10-30(33,34)17-37)16-27(42)39(21-7-8-21)15-26(41)35-13-19-4-2-5-24(31)28(19)32/h2,4-6,9,12,14,21H,3,7-8,10-11,13,15-17H2,1H3,(H,35,41)(H,36,43)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474782
PNG
(US10849883, Compound 212a)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C26H23ClFN7O3/c27-20-3-1-2-16(24(20)28)11-32-22(36)12-34(18-5-6-18)23(37)13-35-21-7-4-15(17-9-30-14-31-10-17)8-19(21)25(33-35)26(29)38/h1-4,7-10,14,18H,5-6,11-13H2,(H2,29,38)(H,32,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474789
PNG
(US10849883, Compound 220a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2cc(NC(=O)Nc3cccnc3)ccc12
Show InChI InChI=1S/C28H28ClFN8O4/c1-16(2)37(14-23(39)33-12-17-5-3-7-21(29)25(17)30)24(40)15-38-22-9-8-18(11-20(22)26(36-38)27(31)41)34-28(42)35-19-6-4-10-32-13-19/h3-11,13,16H,12,14-15H2,1-2H3,(H2,31,41)(H,33,39)(H2,34,35,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474794
PNG
(US10849883, Compound 224a)
Show SMILES CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(C)=O)c2cc(ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C31H31ClFN5O4/c1-19(2)37(17-27(40)34-16-23-10-7-11-25(32)29(23)33)28(41)18-38-26-13-12-22(14-24(26)30(36-38)20(3)39)31(42)35-15-21-8-5-4-6-9-21/h4-14,19H,15-18H2,1-3H3,(H,34,40)(H,35,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474820
PNG
(US10849883, Compound 247a)
Show SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CC2)c2ccc(NC(=O)N3CCC(F)(F)C3)cc12
Show InChI InChI=1S/C27H27ClF3N7O4/c28-19-3-1-2-15(23(19)29)11-33-21(39)12-37(17-5-6-17)22(40)13-38-20-7-4-16(10-18(20)24(35-38)25(32)41)34-26(42)36-9-8-27(30,31)14-36/h1-4,7,10,17H,5-6,8-9,11-14H2,(H2,32,41)(H,33,39)(H,34,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474829
PNG
(US10849883, Compound 256a)
Show SMILES CC(C)N(CC(=O)Nc1cccc(c1F)-c1ccccc1Cl)C(=O)Cn1nc(C(N)=O)c2cc(NC(=O)Nc3cncnc3)ccc12
Show InChI InChI=1S/C32H29ClFN9O4/c1-18(2)42(15-27(44)40-25-9-5-7-22(29(25)34)21-6-3-4-8-24(21)33)28(45)16-43-26-11-10-19(12-23(26)30(41-43)31(35)46)38-32(47)39-20-13-36-17-37-14-20/h3-14,17-18H,15-16H2,1-2H3,(H2,35,46)(H,40,44)(H2,38,39,47)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Complement factor D


(Homo sapiens (Human))
BDBM474832
PNG
(US10849883, Compound 259a)
Show SMILES CC(C)N(CC(=O)Nc1cccc(Br)n1)C(=O)Cn1nc(C(N)=O)c2cc(NC(=O)N3CCCCC3)ccc12
Show InChI InChI=1S/C26H31BrN8O4/c1-16(2)34(14-22(36)31-21-8-6-7-20(27)30-21)23(37)15-35-19-10-9-17(13-18(19)24(32-35)25(28)38)29-26(39)33-11-4-3-5-12-33/h6-10,13,16H,3-5,11-12,14-15H2,1-2H3,(H2,28,38)(H,29,39)(H,30,31,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

US Patent


Assay Description
An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...


US Patent US10849883 (2020)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 380 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%