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Patent code US10849901

Compile Data Set for Download or QSAR
Found 159 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADP-ribosylation factor 6


(Human)
BDBM474951
PNG
(US10849901, Compound 1)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2cccc(c2)-c2cccnc2)c1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H13Cl2F3N4O/c25-17-7-6-15(10-18(17)26)21-22(24(27,28)29)32-33-20(34)11-19(31-23(21)33)14-4-1-3-13(9-14)16-5-2-8-30-12-16/h1-12,31H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.25n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474952
PNG
(US10849901, Compound 2)
Show SMILES Fc1cc(F)cc(Oc2cccc(c2)-c2cc(=O)n3nc(c(-c4ccc(Cl)c(Cl)c4)c3[nH]2)C(F)(F)F)c1
Show InChI InChI=1S/C25H12Cl2F5N3O2/c26-18-5-4-13(7-19(18)27)22-23(25(30,31)32)34-35-21(36)11-20(33-24(22)35)12-2-1-3-16(6-12)37-17-9-14(28)8-15(29)10-17/h1-11,33H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.330n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474954
PNG
(US10849901, Compound 4)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2cccc(Oc3ccccc3)c2)c1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C25H14Cl2F3N3O2/c26-18-10-9-15(12-19(18)27)22-23(25(28,29)30)32-33-21(34)13-20(31-24(22)33)14-5-4-8-17(11-14)35-16-6-2-1-3-7-16/h1-13,31H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.460n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474953
PNG
(US10849901, Compound 3)
Show SMILES FC(F)(F)c1nn2c(N=C(CC2=O)c2ccc(NC(=O)c3ccccc3)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H16ClF3N4O2/c27-18-10-6-16(7-11-18)22-23(26(28,29)30)33-34-21(35)14-20(32-24(22)34)15-8-12-19(13-9-15)31-25(36)17-4-2-1-3-5-17/h1-13H,14H2,(H,31,36)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474954
PNG
(US10849901, Compound 4)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2cccc(Oc3ccccc3)c2)c1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C25H14Cl2F3N3O2/c26-18-10-9-15(12-19(18)27)22-23(25(28,29)30)32-33-21(34)13-20(31-24(22)33)14-5-4-8-17(11-14)35-16-6-2-1-3-7-16/h1-13,31H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.520n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475063
PNG
(US10849901, Compound 113)
Show SMILES CCC(C)(C)C1CCc2c(C1)sc1NC(NC(=O)c21)c1cc(OC)c(O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C22H27N3O5S/c1-5-22(2,3)12-6-7-13-16(10-12)31-21-17(13)20(27)23-19(24-21)11-8-14(25(28)29)18(26)15(9-11)30-4/h8-9,12,19,24,26H,5-7,10H2,1-4H3,(H,23,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.560n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474955
PNG
(US10849901, Compound 5)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)c(Cl)c3)c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C24H14Cl2N4O3/c25-18-11-8-16(12-19(18)26)22-23(15-4-2-1-3-5-15)28-29-21(31)13-20(27-24(22)29)14-6-9-17(10-7-14)30(32)33/h1-13,27H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.580n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474957
PNG
(US10849901, Compound 7)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)c(Cl)c3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H9Cl2F3N4O3/c20-12-6-3-10(7-13(12)21)16-17(19(22,23)24)26-27-15(29)8-14(25-18(16)27)9-1-4-11(5-2-9)28(30)31/h1-8,25H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.660n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474956
PNG
(US10849901, Compound 6)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccc(Oc3ccccc3)cc2)c1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C25H14Cl2F3N3O2/c26-18-11-8-15(12-19(18)27)22-23(25(28,29)30)32-33-21(34)13-20(31-24(22)33)14-6-9-17(10-7-14)35-16-4-2-1-3-5-16/h1-13,31H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.660n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474958
PNG
(US10849901, Compound 8)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)c(c3)C(F)(F)F)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H9ClF6N4O3/c21-13-6-3-10(7-12(13)19(22,23)24)16-17(20(25,26)27)29-30-15(32)8-14(28-18(16)30)9-1-4-11(5-2-9)31(33)34/h1-8,28H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.670n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474959
PNG
(US10849901, Compound 9)
Show SMILES FC(F)(F)c1nn2c([nH]c(Cc3ccccc3)cc2=O)c1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2F3N3O/c21-14-7-6-12(9-15(14)22)17-18(20(23,24)25)27-28-16(29)10-13(26-19(17)28)8-11-4-2-1-3-5-11/h1-7,9-10,26H,8H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.840n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474960
PNG
(US10849901, Compound 10)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1[nH]c2c(c(nn2c(=O)c1Cl)C(F)(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H9Cl2F3N4O3/c20-11-5-1-9(2-6-11)13-16(19(22,23)24)26-27-17(13)25-15(14(21)18(27)29)10-3-7-12(8-4-10)28(30)31/h1-8,25H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.880n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474962
PNG
(US10849901, Compound 12)
Show SMILES Cc1ccc(cn1)-c1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C25H16ClF3N4O/c1-14-5-6-18(13-30-14)16-3-2-4-17(11-16)20-12-21(34)33-24(31-20)22(23(32-33)25(27,28)29)15-7-9-19(26)10-8-15/h2-13,31H,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.960n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474961
PNG
(US10849901, Compound 11)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C24H15ClN4O3/c25-18-10-6-16(7-11-18)22-23(17-4-2-1-3-5-17)27-28-21(30)14-20(26-24(22)28)15-8-12-19(13-9-15)29(31)32/h1-14,26H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.960n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474963
PNG
(US10849901, Compound 13)
Show SMILES FC(F)(F)c1nn2c([nH]c(-c3ccccc3)c(Cl)c2=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H10Cl2F3N3O/c20-12-8-6-10(7-9-12)13-16(19(22,23)24)26-27-17(13)25-15(14(21)18(27)28)11-4-2-1-3-5-11/h1-9,25H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.980n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474964
PNG
(US10849901, Compound 14)
Show SMILES Clc1ccc(cc1Cl)-c1c(nn2c1[nH]c(cc2=O)-c1cccc(Oc2ccccc2)c1)C1CC1
Show InChI InChI=1S/C27H19Cl2N3O2/c28-21-12-11-18(14-22(21)29)25-26(16-9-10-16)31-32-24(33)15-23(30-27(25)32)17-5-4-8-20(13-17)34-19-6-2-1-3-7-19/h1-8,11-16,30H,9-10H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474966
PNG
(US10849901, Compound 16)
Show SMILES CCC(=O)Nc1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C22H16ClF3N4O2/c1-2-17(31)27-15-9-5-12(6-10-15)16-11-18(32)30-21(28-16)19(20(29-30)22(24,25)26)13-3-7-14(23)8-4-13/h3-11,28H,2H2,1H3,(H,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475064
PNG
(US10849901, Compound 114)
Show SMILES Nn1c(cc2c(C#N)c(=O)n(nc2c1=O)-c1ccc(Cl)cc1)-c1ccccc1Cl
Show InChI InChI=1S/C20H11Cl2N5O2/c21-11-5-7-12(8-6-11)27-19(28)15(10-23)14-9-17(13-3-1-2-4-16(13)22)26(24)20(29)18(14)25-27/h1-9H,24H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474970
PNG
(US10849901, Compound 20)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3cccc4ccccc34)c2[nH]1
Show InChI InChI=1S/C29H20N4O3/c34-27-18-25(21-13-15-22(16-14-21)33(35)36)30-29-28(24-12-6-10-20-9-4-5-11-23(20)24)26(31-32(27)29)17-19-7-2-1-3-8-19/h1-16,18,30H,17H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474969
PNG
(US10849901, Compound 19)
Show SMILES CN(C)c1ccc(cn1)-c1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C26H19ClF3N5O/c1-34(2)21-11-8-18(14-31-21)16-4-3-5-17(12-16)20-13-22(36)35-25(32-20)23(24(33-35)26(28,29)30)15-6-9-19(27)10-7-15/h3-14,32H,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474968
PNG
(US10849901, Compound 18)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H18N4O3/c1-16-24(20-9-7-18(8-10-20)17-5-3-2-4-6-17)25-26-22(15-23(30)28(25)27-16)19-11-13-21(14-12-19)29(31)32/h2-15,26H,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474965
PNG
(US10849901, Compound 15)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccc(Br)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H10BrClF3N3O/c20-12-5-1-10(2-6-12)14-9-15(28)27-18(25-14)16(17(26-27)19(22,23)24)11-3-7-13(21)8-4-11/h1-9,25H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474956
PNG
(US10849901, Compound 6)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccc(Oc3ccccc3)cc2)c1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C25H14Cl2F3N3O2/c26-18-11-8-15(12-19(18)27)22-23(25(28,29)30)32-33-21(34)13-20(31-24(22)33)14-6-9-17(10-7-14)35-16-4-2-1-3-5-16/h1-13,31H
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM33301
PNG
(US10849901, Compound 115 | rhodanine, 1-2)
Show SMILES Cc1cccc(c1)N1C(=S)S\C(=C/c2cc(cc(Br)c2O)[N+]([O-])=O)C1=O
Show InChI InChI=1S/C17H11BrN2O4S2/c1-9-3-2-4-11(5-9)19-16(22)14(26-17(19)25)7-10-6-12(20(23)24)8-13(18)15(10)21/h2-8,21H,1H3/b14-7-
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n/an/a 1.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474967
PNG
(US10849901, Compound 17)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccc(cc2)-c2cccnc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H14ClF3N4O/c25-18-9-7-16(8-10-18)21-22(24(26,27)28)31-32-20(33)12-19(30-23(21)32)15-5-3-14(4-6-15)17-2-1-11-29-13-17/h1-13,30H
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474972
PNG
(US10849901, Compound 22 | US10849901, Compound 27)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(C3CC3)c(-c3ccc(Cl)c(Cl)c3)c2[nH]1
Show InChI InChI=1S/C21H14Cl2N4O3/c22-15-8-5-13(9-16(15)23)19-20(12-1-2-12)25-26-18(28)10-17(24-21(19)26)11-3-6-14(7-4-11)27(29)30/h3-10,12,24H,1-2H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475092
PNG
(US10849901, Compound 142)
Show SMILES Fc1ccc(cc1)C1=CCN(CC1)c1nc(nc2CNCc12)-c1ccncc1
Show InChI InChI=1S/C22H20FN5/c23-18-3-1-15(2-4-18)16-7-11-28(12-8-16)22-19-13-25-14-20(19)26-21(27-22)17-5-9-24-10-6-17/h1-7,9-10,25H,8,11-14H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474973
PNG
(US10849901, Compound 23)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)c(Cl)c3)c2[nH]1
Show InChI InChI=1S/C25H16Cl2N4O3/c26-19-11-8-17(13-20(19)27)24-22(12-15-4-2-1-3-5-15)29-30-23(32)14-21(28-25(24)30)16-6-9-18(10-7-16)31(33)34/h1-11,13-14,28H,12H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474971
PNG
(US10849901, Compound 21)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H10ClF3N4O3/c20-12-6-4-10(5-7-12)16-17(19(21,22)23)25-26-15(28)9-14(24-18(16)26)11-2-1-3-13(8-11)27(29)30/h1-9,24H
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474974
PNG
(US10849901, Compound 24)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1[nH]c2c(c(Cc3ccccc3)nn2c(=O)c1Cl)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H16Cl2N4O3/c26-18-10-6-16(7-11-18)21-20(14-15-4-2-1-3-5-15)29-30-24(21)28-23(22(27)25(30)32)17-8-12-19(13-9-17)31(33)34/h1-13,28H,14H2
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n/an/a 1.30n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474972
PNG
(US10849901, Compound 22 | US10849901, Compound 27)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(C3CC3)c(-c3ccc(Cl)c(Cl)c3)c2[nH]1
Show InChI InChI=1S/C21H14Cl2N4O3/c22-15-8-5-13(9-16(15)23)19-20(12-1-2-12)25-26-18(28)10-17(24-21(19)26)11-3-6-14(7-4-11)27(29)30/h3-10,12,24H,1-2H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474974
PNG
(US10849901, Compound 24)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1[nH]c2c(c(Cc3ccccc3)nn2c(=O)c1Cl)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H16Cl2N4O3/c26-18-10-6-16(7-11-18)21-20(14-15-4-2-1-3-5-15)29-30-24(21)28-23(22(27)25(30)32)17-8-12-19(13-9-17)31(33)34/h1-13,28H,14H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475066
PNG
(US10849901, Compound 116)
Show SMILES CCOc1ccc(cc1C)-c1nn(cc1\C=C1/SC(=S)N(CCC(O)=O)C1=O)-c1ccccc1
Show InChI InChI=1S/C25H23N3O4S2/c1-3-32-20-10-9-17(13-16(20)2)23-18(15-28(26-23)19-7-5-4-6-8-19)14-21-24(31)27(25(33)34-21)12-11-22(29)30/h4-10,13-15H,3,11-12H2,1-2H3,(H,29,30)/b21-14-
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474978
PNG
(US10849901, Compound 28)
Show SMILES CC(c1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)cc1)c1ccccc1
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474976
PNG
(US10849901, Compound 26)
Show SMILES COc1cc(ccc1Cl)-c1c(C)nn2c1[nH]c(cc2=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C20H15ClN4O4/c1-11-19(13-5-8-15(21)17(9-13)29-2)20-22-16(10-18(26)24(20)23-11)12-3-6-14(7-4-12)25(27)28/h3-10,22H,1-2H3
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474975
PNG
(US10849901, Compound 25)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccc(Cl)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H10Cl2F3N3O/c20-12-5-1-10(2-6-12)14-9-15(28)27-18(25-14)16(17(26-27)19(22,23)24)11-3-7-13(21)8-4-11/h1-9,25H
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM50168142
PNG
(CHEMBL3716578 | US10849901, Compound 38 | US109530...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C25H17ClN4O3/c26-19-10-6-18(7-11-19)24-22(14-16-4-2-1-3-5-16)28-29-23(31)15-21(27-25(24)29)17-8-12-20(13-9-17)30(32)33/h1-13,15,27H,14H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474982
PNG
(US10849901, Compound 32)
Show SMILES CC(C)(C)c1nn2c([nH]c(cc2=O)-c2ccccc2C#N)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClN4O/c1-23(2,3)21-20(14-8-10-16(24)11-9-14)22-26-18(12-19(29)28(22)27-21)17-7-5-4-6-15(17)13-25/h4-12,26H,1-3H3
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474981
PNG
(US10849901, Compound 31)
Show SMILES COc1ccc(cn1)-c1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C25H16ClF3N4O2/c1-35-20-10-7-17(13-30-20)15-3-2-4-16(11-15)19-12-21(34)33-24(31-19)22(23(32-33)25(27,28)29)14-5-8-18(26)9-6-14/h2-13,31H,1H3
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475067
PNG
(US10849901, Compound 117)
Show SMILES O=c1cc(CSc2nc3\C(CCc3c(-c3ccccc3)c2C#N)=C\c2ccccc2)[nH]c(=O)[nH]1
Show InChI InChI=1S/C27H20N4O2S/c28-15-22-24(18-9-5-2-6-10-18)21-12-11-19(13-17-7-3-1-4-8-17)25(21)31-26(22)34-16-20-14-23(32)30-27(33)29-20/h1-10,13-14H,11-12,16H2,(H2,29,30,32,33)/b19-13+
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474979
PNG
(US10849901, Compound 29 | US10953012, Example 25)
Show SMILES Clc1ccc(cc1)-c1c(Cc2ccccc2)nn2c1[nH]c(cc2=O)-c1ccccc1
Show InChI InChI=1S/C25H18ClN3O/c26-20-13-11-19(12-14-20)24-22(15-17-7-3-1-4-8-17)28-29-23(30)16-21(27-25(24)29)18-9-5-2-6-10-18/h1-14,16,27H,15H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474980
PNG
(US10849901, Compound 30)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H18N4O4/c1-16-24(18-9-13-21(14-10-18)33-20-5-3-2-4-6-20)25-26-22(15-23(30)28(25)27-16)17-7-11-19(12-8-17)29(31)32/h2-15,26H,1H3
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474984
PNG
(US10849901, Compound 34)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2cccc(Br)c2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H10BrClF3N3O/c20-12-3-1-2-11(8-12)14-9-15(28)27-18(25-14)16(17(26-27)19(22,23)24)10-4-6-13(21)7-5-10/h1-9,25H
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n/an/a 1.60n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474983
PNG
(US10849901, Compound 33)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H10ClF3N4O3/c20-12-5-1-11(2-6-12)16-17(19(21,22)23)25-26-15(28)9-14(24-18(16)26)10-3-7-13(8-4-10)27(29)30/h1-9,24H
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474959
PNG
(US10849901, Compound 9)
Show SMILES FC(F)(F)c1nn2c([nH]c(Cc3ccccc3)cc2=O)c1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2F3N3O/c21-14-7-6-12(9-15(14)22)17-18(20(23,24)25)27-28-16(29)10-13(26-19(17)28)8-11-4-2-1-3-5-11/h1-7,9-10,26H,8H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474987
PNG
(US10849901, Compound 37)
Show SMILES Oc1cc(ccc1-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1)[N+]([O-])=O
Show InChI InChI=1S/C25H17ClN4O4/c26-17-8-6-16(7-9-17)24-21(12-15-4-2-1-3-5-15)28-29-23(32)14-20(27-25(24)29)19-11-10-18(30(33)34)13-22(19)31/h1-11,13-14,27,31H,12H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474985
PNG
(US10849901, Compound 35)
Show SMILES CC(C)CC(=O)Nc1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C24H20ClF3N4O2/c1-13(2)11-19(33)29-17-9-5-14(6-10-17)18-12-20(34)32-23(30-18)21(22(31-32)24(26,27)28)15-3-7-16(25)8-4-15/h3-10,12-13,30H,11H2,1-2H3,(H,29,33)
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474986
PNG
(US10849901, Compound 36 | US10849901, Compound 76)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H12Cl2N4O3/c1-10-18(14-7-4-12(20)8-15(14)21)19-22-16(9-17(26)24(19)23-10)11-2-5-13(6-3-11)25(27)28/h2-9,22H,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM50168142
PNG
(CHEMBL3716578 | US10849901, Compound 38 | US109530...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C25H17ClN4O3/c26-19-10-6-18(7-11-19)24-22(14-16-4-2-1-3-5-16)28-29-23(31)15-21(27-25(24)29)17-8-12-20(13-9-17)30(32)33/h1-13,15,27H,14H2
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n/an/a 1.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475068
PNG
(US10849901, Compound 118)
Show SMILES Clc1ccc(cc1)-n1cccc1\C=C1/C(=O)NC(=S)N(C1=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H13Cl2N3O2S/c22-13-6-8-15(9-7-13)25-10-2-5-16(25)12-18-19(27)24-21(29)26(20(18)28)17-4-1-3-14(23)11-17/h1-12H,(H,24,27,29)/b18-12+
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n/an/a 1.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474989
PNG
(US10849901, Compound 39 | US10953012, Example 1)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H13ClN4O3/c1-11-18(13-2-6-14(20)7-3-13)19-21-16(10-17(25)23(19)22-11)12-4-8-15(9-5-12)24(26)27/h2-10,21H,1H3
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n/an/a 1.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474990
PNG
(US10849901, Compound 40)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccc(cc2)C#N)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H10ClF3N4O/c21-14-7-5-13(6-8-14)17-18(20(22,23)24)27-28-16(29)9-15(26-19(17)28)12-3-1-11(10-25)2-4-12/h1-9,26H
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n/an/a 1.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474991
PNG
(US10849901, Compound 41)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(NC(=O)Cc3ccccc3)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H21ClN4O2/c1-17-26(20-7-11-21(28)12-8-20)27-30-23(16-25(34)32(27)31-17)19-9-13-22(14-10-19)29-24(33)15-18-5-3-2-4-6-18/h2-14,16,30H,15H2,1H3,(H,29,33)
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n/an/a 1.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475069
PNG
(US10849901, Compound 119)
Show SMILES Oc1c(Br)cc(Cl)cc1C(=O)Nc1cc(Cl)c(c(Cl)c1)-c1cccc2cccnc12
Show InChI InChI=1S/C22H12BrCl3N2O2/c23-16-8-12(24)7-15(21(16)29)22(30)28-13-9-17(25)19(18(26)10-13)14-5-1-3-11-4-2-6-27-20(11)14/h1-10,29H,(H,28,30)
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n/an/a 2.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474992
PNG
(US10849901, Compound 42)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(NC(=O)NCc3ccccc3)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H22ClN5O2/c1-17-25(20-7-11-21(28)12-8-20)26-31-23(15-24(34)33(26)32-17)19-9-13-22(14-10-19)30-27(35)29-16-18-5-3-2-4-6-18/h2-15,31H,16H2,1H3,(H2,29,30,35)
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n/an/a 2.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474993
PNG
(US10849901, Compound 43)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H12Cl2N4O3/c1-10-18(12-6-13(20)8-14(21)7-12)19-22-16(9-17(26)24(19)23-10)11-2-4-15(5-3-11)25(27)28/h2-9,22H,1H3
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474994
PNG
(US10849901, Compound 44)
Show SMILES CC(C)(C)c1nn2c([nH]c(cc2=O)-c2cccc(c2)C#N)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClN4O/c1-23(2,3)21-20(15-7-9-17(24)10-8-15)22-26-18(12-19(29)28(22)27-21)16-6-4-5-14(11-16)13-25/h4-12,26H,1-3H3
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n/an/a 2.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474995
PNG
(US10849901, Compound 45)
Show SMILES CC(c1ccccc1)c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
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n/an/a 2.30n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474997
PNG
(US10849901, Compound 47)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccc(cc2)-c2ccncc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H14ClF3N4O/c25-18-7-5-17(6-8-18)21-22(24(26,27)28)31-32-20(33)13-19(30-23(21)32)16-3-1-14(2-4-16)15-9-11-29-12-10-15/h1-13,30H
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n/an/a 2.40n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474996
PNG
(US10849901, Compound 46)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccncc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C24H16ClN5O3/c25-18-5-1-17(2-6-18)23-21(13-15-9-11-26-12-10-15)28-29-22(31)14-20(27-24(23)29)16-3-7-19(8-4-16)30(32)33/h1-12,14,27H,13H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474998
PNG
(US10849901, Compound 48)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(NC(=O)c3ccccc3)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H19ClN4O2/c1-16-24(18-7-11-20(27)12-8-18)25-29-22(15-23(32)31(25)30-16)17-9-13-21(14-10-17)28-26(33)19-5-3-2-4-6-19/h2-15,29H,1H3,(H,28,33)
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475000
PNG
(US10849901, Compound 50)
Show SMILES CC(C)CC(=O)Nc1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C24H20ClF3N4O2/c1-13(2)10-19(33)29-17-5-3-4-15(11-17)18-12-20(34)32-23(30-18)21(22(31-32)24(26,27)28)14-6-8-16(25)9-7-14/h3-9,11-13,30H,10H2,1-2H3,(H,29,33)
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n/an/a 2.5n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474999
PNG
(US10849901, Compound 49)
Show SMILES Clc1ccc(cc1)-c1c(Cc2ccccc2)nn2c1[nH]c(-c1ccccc1)c(Cl)c2=O
Show InChI InChI=1S/C25H17Cl2N3O/c26-19-13-11-17(12-14-19)21-20(15-16-7-3-1-4-8-16)29-30-24(21)28-23(22(27)25(30)31)18-9-5-2-6-10-18/h1-14,28H,15H2
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n/an/a 2.5n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474983
PNG
(US10849901, Compound 33)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H10ClF3N4O3/c20-12-5-1-11(2-6-12)16-17(19(21,22)23)25-26-15(28)9-14(24-18(16)26)10-3-7-13(8-4-10)27(29)30/h1-9,24H
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n/an/a 2.60n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475006
PNG
(US10849901, Compound 56)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C28H23ClN4O2/c1-32(2)28(35)21-10-8-19(9-11-21)23-17-25(34)33-27(30-23)26(20-12-14-22(29)15-13-20)24(31-33)16-18-6-4-3-5-7-18/h3-15,17,30H,16H2,1-2H3
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n/an/a 2.60n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475001
PNG
(US10849901, Compound 51)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1cccc2ccccc12
Show InChI InChI=1S/C23H16N4O3/c1-14-22(19-8-4-6-15-5-2-3-7-18(15)19)23-24-20(13-21(28)26(23)25-14)16-9-11-17(12-10-16)27(29)30/h2-13,24H,1H3
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n/an/a 2.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475002
PNG
(US10849901, Compound 52)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3cccnc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C24H16ClN5O3/c25-18-7-3-17(4-8-18)23-21(12-15-2-1-11-26-14-15)28-29-22(31)13-20(27-24(23)29)16-5-9-19(10-6-16)30(32)33/h1-11,13-14,27H,12H2
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n/an/a 2.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475016
PNG
(US10849901, Compound 66)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C26H19ClN4O2/c27-20-12-10-18(11-13-20)24-22(14-16-4-2-1-3-5-16)30-31-23(32)15-21(29-26(24)31)17-6-8-19(9-7-17)25(28)33/h1-13,15,29H,14H2,(H2,28,33)
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n/an/a 2.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475004
PNG
(US10849901, Compound 54)
Show SMILES CSc1ccc(Cc2nn3c([nH]c(cc3=O)-c3ccc(cc3)[N+]([O-])=O)c2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C26H19ClN4O3S/c1-35-21-12-2-16(3-13-21)14-23-25(18-4-8-19(27)9-5-18)26-28-22(15-24(32)30(26)29-23)17-6-10-20(11-7-17)31(33)34/h2-13,15,28H,14H2,1H3
PDB

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n/an/a 3n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475003
PNG
(US10849901, Compound 53)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2cccc(c2)-c2cccnc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H17ClN4O/c1-15-23(16-7-9-20(25)10-8-16)24-27-21(13-22(30)29(24)28-15)18-5-2-4-17(12-18)19-6-3-11-26-14-19/h2-14,27H,1H3
PDB

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n/an/a 3n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475005
PNG
(US10849901, Compound 55)
Show SMILES COc1ccc(cc1)-c1c(Cc2ccccc2)nn2c1[nH]c(cc2=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C26H20N4O4/c1-34-21-13-9-19(10-14-21)25-23(15-17-5-3-2-4-6-17)28-29-24(31)16-22(27-26(25)29)18-7-11-20(12-8-18)30(32)33/h2-14,16,27H,15H2,1H3
PDB

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n/an/a 3.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475009
PNG
(US10849901, Compound 59)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccccc3)c2[nH]1
Show InChI InChI=1S/C25H18N4O3/c30-23-16-21(18-11-13-20(14-12-18)29(31)32)26-25-24(19-9-5-2-6-10-19)22(27-28(23)25)15-17-7-3-1-4-8-17/h1-14,16,26H,15H2
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n/an/a 3.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475006
PNG
(US10849901, Compound 56)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C28H23ClN4O2/c1-32(2)28(35)21-10-8-19(9-11-21)23-17-25(34)33-27(30-23)26(20-12-14-22(29)15-13-20)24(31-33)16-18-6-4-3-5-7-18/h3-15,17,30H,16H2,1-2H3
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n/an/a 3.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475008
PNG
(US10849901, Compound 58)
Show SMILES Clc1ccc(cc1)-c1c(nn2c1[nH]c(cc2=O)-c1ccc(cc1)C#N)C1CC1
Show InChI InChI=1S/C22H15ClN4O/c23-17-9-7-15(8-10-17)20-21(16-5-6-16)26-27-19(28)11-18(25-22(20)27)14-3-1-13(12-24)2-4-14/h1-4,7-11,16,25H,5-6H2
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n/an/a 3.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475010
PNG
(US10849901, Compound 60)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2ncc(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C18H11ClN4O3/c19-13-5-1-11(2-6-13)15-10-20-22-17(24)9-16(21-18(15)22)12-3-7-14(8-4-12)23(25)26/h1-10,21H
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n/an/a 3.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475007
PNG
(US10849901, Compound 57)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C19H12Cl2N4O3/c1-10-17(13-3-2-4-14(20)18(13)21)19-22-15(9-16(26)24(19)23-10)11-5-7-12(8-6-11)25(27)28/h2-9,22H,1H3
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n/an/a 3.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474996
PNG
(US10849901, Compound 46)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccncc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C24H16ClN5O3/c25-18-5-1-17(2-6-18)23-21(13-15-9-11-26-12-10-15)28-29-22(31)14-20(27-24(23)29)16-3-7-19(8-4-16)30(32)33/h1-12,14,27H,13H2
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n/an/a 3.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475011
PNG
(US10849901, Compound 61)
Show SMILES CCC(=O)Nc1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C22H16ClF3N4O2/c1-2-17(31)27-15-5-3-4-13(10-15)16-11-18(32)30-21(28-16)19(20(29-30)22(24,25)26)12-6-8-14(23)9-7-12/h3-11,28H,2H2,1H3,(H,27,31)
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n/an/a 3.30n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474979
PNG
(US10849901, Compound 29 | US10953012, Example 25)
Show SMILES Clc1ccc(cc1)-c1c(Cc2ccccc2)nn2c1[nH]c(cc2=O)-c1ccccc1
Show InChI InChI=1S/C25H18ClN3O/c26-20-13-11-19(12-14-20)24-22(15-17-7-3-1-4-8-17)28-29-23(30)16-21(27-25(24)29)18-9-5-2-6-10-18/h1-14,16,27H,15H2
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n/an/a 3.30n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475012
PNG
(US10849901, Compound 62)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2ccccc2Br)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H10BrClF3N3O/c20-13-4-2-1-3-12(13)14-9-15(28)27-18(25-14)16(17(26-27)19(22,23)24)10-5-7-11(21)8-6-10/h1-9,25H
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n/an/a 3.30n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475070
PNG
(US10849901, Compound 120)
Show SMILES FC(F)(F)c1cc(\C=C\c2ccc(o2)-c2cc(Cl)cc(Cl)c2)nc(=O)[nH]1
Show InChI InChI=1S/C17H9Cl2F3N2O2/c18-10-5-9(6-11(19)7-10)14-4-3-13(26-14)2-1-12-8-15(17(20,21)22)24-16(25)23-12/h1-8H,(H,23,24,25)/b2-1+
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n/an/a 3.40n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475013
PNG
(US10849901, Compound 63)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(CC3CCOCC3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C24H21ClN4O4/c25-18-5-1-17(2-6-18)23-21(13-15-9-11-33-12-10-15)27-28-22(30)14-20(26-24(23)28)16-3-7-19(8-4-16)29(31)32/h1-8,14-15,26H,9-13H2
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n/an/a 3.60n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475014
PNG
(US10849901, Compound 64)
Show SMILES COc1ccc(Cc2nn3c([nH]c(cc3=O)-c3ccc(cc3)[N+]([O-])=O)c2-c2ccccc2)cc1
Show InChI InChI=1S/C26H20N4O4/c1-34-21-13-7-17(8-14-21)15-23-25(19-5-3-2-4-6-19)26-27-22(16-24(31)29(26)28-23)18-9-11-20(12-10-18)30(32)33/h2-14,16,27H,15H2,1H3
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n/an/a 3.60n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475015
PNG
(US10849901, Compound 65)
Show SMILES FC(F)(F)c1nn2c([nH]c(Cc3ccccc3)cc2=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13ClF3N3O/c21-14-8-6-13(7-9-14)17-18(20(22,23)24)26-27-16(28)11-15(25-19(17)27)10-12-4-2-1-3-5-12/h1-9,11,25H,10H2
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n/an/a 3.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475016
PNG
(US10849901, Compound 66)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C26H19ClN4O2/c27-20-12-10-18(11-13-20)24-22(14-16-4-2-1-3-5-16)30-31-23(32)15-21(29-26(24)31)17-6-8-19(9-7-17)25(28)33/h1-13,15,29H,14H2,(H2,28,33)
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n/an/a 3.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475017
PNG
(US10849901, Compound 67)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C21H14ClF3N4O2/c1-11(30)26-15-8-4-12(5-9-15)16-10-17(31)29-20(27-16)18(19(28-29)21(23,24)25)13-2-6-14(22)7-3-13/h2-10,27H,1H3,(H,26,30)
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n/an/a 3.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475071
PNG
(US10849901, Compound 121)
Show SMILES O=C1NC(=S)S\C1=C\c1ccc(cc1)N1N=C(CC1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H19N3OS2/c29-24-23(31-25(30)26-24)15-17-11-13-20(14-12-17)28-22(19-9-5-2-6-10-19)16-21(27-28)18-7-3-1-4-8-18/h1-15,22H,16H2,(H,26,29,30)/b23-15+
PDB

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n/an/a 3.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475022
PNG
(US10849901, Compound 72)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccccc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H11F3N4O3/c20-19(21,22)17-16(12-4-2-1-3-5-12)18-23-14(10-15(27)25(18)24-17)11-6-8-13(9-7-11)26(28)29/h1-10,23H
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n/an/a 3.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475018
PNG
(US10849901, Compound 68)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(NS(=O)(=O)Cc3ccccc3)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H21ClN4O3S/c1-17-25(20-7-11-21(27)12-8-20)26-28-23(15-24(32)31(26)29-17)19-9-13-22(14-10-19)30-35(33,34)16-18-5-3-2-4-6-18/h2-15,28,30H,16H2,1H3
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n/an/a 3.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475019
PNG
(US10849901, Compound 69)
Show SMILES Cc1nc2n(nc([nH]c2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12ClN5O3/c1-10-15(11-2-6-13(19)7-3-11)23-17(20-10)18(25)21-16(22-23)12-4-8-14(9-5-12)24(26)27/h2-9H,1H3,(H,21,22,25)
PDB

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n/an/a 4n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475021
PNG
(US10849901, Compound 71)
Show SMILES COC(=O)c1ccc(cc1)-c1cc(=O)n2nc(C3CC3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C23H18ClN3O3/c1-30-23(29)16-6-2-13(3-7-16)18-12-19(28)27-22(25-18)20(21(26-27)15-4-5-15)14-8-10-17(24)11-9-14/h2-3,6-12,15,25H,4-5H2,1H3
PDB

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n/an/a 4.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475020
PNG
(US10849901, Compound 70)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2cccc(c2)-c2ccncc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H17ClN4O/c1-15-23(17-5-7-20(25)8-6-17)24-27-21(14-22(30)29(24)28-15)19-4-2-3-18(13-19)16-9-11-26-12-10-16/h2-14,27H,1H3
PDB

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n/an/a 4.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475023
PNG
(US10849901, Compound 73)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C19H12ClFN4O3/c1-10-18(12-4-7-14(20)15(21)8-12)19-22-16(9-17(26)24(19)23-10)11-2-5-13(6-3-11)25(27)28/h2-9,22H,1H3
PDB

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n/an/a 4.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475022
PNG
(US10849901, Compound 72)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccccc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H11F3N4O3/c20-19(21,22)17-16(12-4-2-1-3-5-12)18-23-14(10-15(27)25(18)24-17)11-6-8-13(9-7-11)26(28)29/h1-10,23H
PDB

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n/an/a 4.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475024
PNG
(US10849901, Compound 74)
Show SMILES CC(=O)Nc1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C21H14ClF3N4O2/c1-11(30)26-15-4-2-3-13(9-15)16-10-17(31)29-20(27-16)18(19(28-29)21(23,24)25)12-5-7-14(22)8-6-12/h2-10,27H,1H3,(H,26,30)
PDB

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n/an/a 4.30n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475025
PNG
(US10849901, Compound 75)
Show SMILES COCC(=O)Nc1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C22H16ClF3N4O3/c1-33-11-17(31)27-15-8-4-12(5-9-15)16-10-18(32)30-21(28-16)19(20(29-30)22(24,25)26)13-2-6-14(23)7-3-13/h2-10,28H,11H2,1H3,(H,27,31)
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n/an/a 4.40n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474986
PNG
(US10849901, Compound 36 | US10849901, Compound 76)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H12Cl2N4O3/c1-10-18(14-7-4-12(20)8-15(14)21)19-22-16(9-17(26)24(19)23-10)11-2-5-13(6-3-11)25(27)28/h2-9,22H,1H3
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n/an/a 4.5n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM474989
PNG
(US10849901, Compound 39 | US10953012, Example 1)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H13ClN4O3/c1-11-18(13-2-6-14(20)7-3-13)19-21-16(10-17(25)23(19)22-11)12-4-8-15(9-5-12)24(26)27/h2-10,21H,1H3
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n/an/a 4.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475072
PNG
(US10849901, Compound 122)
Show SMILES Cc1cccc(c1)-n1c(\C=C\c2cccnc2)nc2ccccc2c1=O
Show InChI InChI=1S/C22H17N3O/c1-16-6-4-8-18(14-16)25-21(12-11-17-7-5-13-23-15-17)24-20-10-3-2-9-19(20)22(25)26/h2-15H,1H3/b12-11+
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n/an/a 4.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475002
PNG
(US10849901, Compound 52)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3cccnc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C24H16ClN5O3/c25-18-7-3-17(4-8-18)23-21(12-15-2-1-11-26-14-15)28-29-22(31)13-20(27-24(23)29)16-5-9-19(10-6-16)30(32)33/h1-11,13-14,27H,12H2
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n/an/a 4.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475001
PNG
(US10849901, Compound 51)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1cccc2ccccc12
Show InChI InChI=1S/C23H16N4O3/c1-14-22(19-8-4-6-15-5-2-3-7-18(15)19)23-24-20(13-21(28)26(23)25-14)16-9-11-17(12-10-16)27(29)30/h2-13,24H,1H3
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n/an/a 4.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475015
PNG
(US10849901, Compound 65)
Show SMILES FC(F)(F)c1nn2c([nH]c(Cc3ccccc3)cc2=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13ClF3N3O/c21-14-8-6-13(7-9-14)17-18(20(22,23)24)26-27-16(28)11-15(25-19(17)27)10-12-4-2-1-3-5-12/h1-9,11,25H,10H2
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n/an/a 4.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475073
PNG
(US10849901, Compound 123)
Show SMILES Nc1scc2c(nn(-c3ccc(cc3)[N+]([O-])=O)c(=O)c12)-c1nnc(Nc2ccccc2)s1
Show InChI InChI=1S/C20H13N7O3S2/c21-17-15-14(10-31-17)16(18-23-24-20(32-18)22-11-4-2-1-3-5-11)25-26(19(15)28)12-6-8-13(9-7-12)27(29)30/h1-10H,21H2,(H,22,24)
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n/an/a 5.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475027
PNG
(US10849901, Compound 77)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(C3CCOCC3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C23H19ClN4O4/c24-17-5-1-15(2-6-17)21-22(16-9-11-32-12-10-16)26-27-20(29)13-19(25-23(21)27)14-3-7-18(8-4-14)28(30)31/h1-8,13,16,25H,9-12H2
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n/an/a 5.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475028
PNG
(US10849901, Compound 78)
Show SMILES Nc1ccc(cc1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H12ClF3N4O/c20-12-5-1-11(2-6-12)16-17(19(21,22)23)26-27-15(28)9-14(25-18(16)27)10-3-7-13(24)8-4-10/h1-9,25H,24H2
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n/an/a 5.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475074
PNG
(US10849901, Compound 124)
Show SMILES O=C1NC(=O)c2ccccc2\C1=C\c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C20H15N3O2/c24-19-17-9-5-4-8-16(17)18(20(25)22-19)10-15-11-21-23(13-15)12-14-6-2-1-3-7-14/h1-11,13H,12H2,(H,22,24,25)/b18-10-
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n/an/a 5.40n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475029
PNG
(US10849901, Compound 79)
Show SMILES Clc1ccc(cc1)-c1c(nn2c1[nH]c(cc2=O)-c1cccc(c1)C#N)C1CC1
Show InChI InChI=1S/C22H15ClN4O/c23-17-8-6-14(7-9-17)20-21(15-4-5-15)26-27-19(28)11-18(25-22(20)27)16-3-1-2-13(10-16)12-24/h1-3,6-11,15,25H,4-5H2
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n/an/a 5.5n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475030
PNG
(US10849901, Compound 80)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(CN3CCOCC3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C23H20ClN5O4/c24-17-5-1-16(2-6-17)22-20(14-27-9-11-33-12-10-27)26-28-21(30)13-19(25-23(22)28)15-3-7-18(8-4-15)29(31)32/h1-8,13,25H,9-12,14H2
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n/an/a 5.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475032
PNG
(US10849901, Compound 82)
Show SMILES CC(C)(C)c1nn2c([nH]c(cc2=O)-c2ccccn2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H19ClN4O/c1-21(2,3)19-18(13-7-9-14(22)10-8-13)20-24-16(12-17(27)26(20)25-19)15-6-4-5-11-23-15/h4-12,24H,1-3H3
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n/an/a 6n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475031
PNG
(US10849901, Compound 81)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H15ClN4O3/c1-12-17(10-13-2-6-15(21)7-3-13)20-22-18(11-19(26)24(20)23-12)14-4-8-16(9-5-14)25(27)28/h2-9,11,22H,10H2,1H3
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n/an/a 6n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475033
PNG
(US10849901, Compound 83)
Show SMILES COc1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C26H20ClN3O2/c1-32-21-13-9-18(10-14-21)22-16-24(31)30-26(28-22)25(19-7-11-20(27)12-8-19)23(29-30)15-17-5-3-2-4-6-17/h2-14,16,28H,15H2,1H3
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n/an/a 6.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475034
PNG
(US10849901, Compound 84)
Show SMILES CC(C)(C)c1nn2c([nH]c(cc2=O)-c2cccnc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H19ClN4O/c1-21(2,3)19-18(13-6-8-15(22)9-7-13)20-24-16(11-17(27)26(20)25-19)14-5-4-10-23-12-14/h4-12,24H,1-3H3
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n/an/a 6.40n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475075
PNG
(US10849901, Compound 125)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(\C=C2/C(=O)NC(=O)c3ccccc23)c1
Show InChI InChI=1S/C24H18N2O4/c1-30-18-11-9-16(10-12-18)22(27)25-17-6-4-5-15(13-17)14-21-19-7-2-3-8-20(19)23(28)26-24(21)29/h2-14H,1H3,(H,25,27)(H,26,28,29)/b21-14-
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n/an/a 6.5n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475036
PNG
(US10849901, Compound 86)
Show SMILES CC(C)(C)c1nn2c([nH]c(cc2=O)-c2cccc(c2)C(O)=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClN3O3/c1-23(2,3)20-19(13-7-9-16(24)10-8-13)21-25-17(12-18(28)27(21)26-20)14-5-4-6-15(11-14)22(29)30/h4-12,25H,1-3H3,(H,29,30)
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n/an/a 6.60n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475035
PNG
(US10849901, Compound 85)
Show SMILES CC(C)(C)c1nn2c([nH]c(cc2=O)-c2cccc(c2)C(N)=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN4O2/c1-23(2,3)20-19(13-7-9-16(24)10-8-13)22-26-17(12-18(29)28(22)27-20)14-5-4-6-15(11-14)21(25)30/h4-12,26H,1-3H3,(H2,25,30)
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n/an/a 6.60n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475037
PNG
(US10849901, Compound 87)
Show SMILES CC(C)(C)c1nn2c([nH]c(cc2=O)-c2cccc(c2)S(C)(=O)=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClN3O3S/c1-23(2,3)21-20(14-8-10-16(24)11-9-14)22-25-18(13-19(28)27(22)26-21)15-6-5-7-17(12-15)31(4,29)30/h5-13,25H,1-4H3
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n/an/a 6.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM50027961
PNG
(CHEMBL3360257 | US10849901, Compound 126)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(O)c2ccccc12
Show InChI InChI=1S/C20H21NO3S/c1-20(2,3)14-8-10-15(11-9-14)25(23,24)21-18-12-13-19(22)17-7-5-4-6-16(17)18/h4-13,21-22H,1-3H3
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n/an/a 6.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475039
PNG
(US10849901, Compound 89 | US10953012, Example 34)
Show SMILES O=c1cc(Cc2ccccc2)[nH]c2c(c(nn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C25H19N3O/c29-22-17-21(16-18-10-4-1-5-11-18)26-25-23(19-12-6-2-7-13-19)24(27-28(22)25)20-14-8-3-9-15-20/h1-15,17,26H,16H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475038
PNG
(US10849901, Compound 88)
Show SMILES Nc1cccc(c1)-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H12ClF3N4O/c20-12-6-4-10(5-7-12)16-17(19(21,22)23)26-27-15(28)9-14(25-18(16)27)11-2-1-3-13(24)8-11/h1-9,25H,24H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475040
PNG
(US10849901, Compound 90)
Show SMILES OCc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H13ClN4O4/c20-13-5-1-12(2-6-13)18-16(10-25)22-23-17(26)9-15(21-19(18)23)11-3-7-14(8-4-11)24(27)28/h1-9,21,25H,10H2
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n/an/a 7.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475041
PNG
(US10849901, Compound 91)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(=O)n2nc(C3CC3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C22H18ClN3O3S/c1-30(28,29)17-10-6-13(7-11-17)18-12-19(27)26-22(24-18)20(21(25-26)15-2-3-15)14-4-8-16(23)9-5-14/h4-12,15,24H,2-3H2,1H3
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n/an/a 7.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475077
PNG
(US10849901, Compound 127)
Show SMILES OC(=O)c1ccc(cc1)C1Nc2c(Br)cccc2C2C=CCC12
Show InChI InChI=1S/C19H16BrNO2/c20-16-6-2-5-15-13-3-1-4-14(13)17(21-18(15)16)11-7-9-12(10-8-11)19(22)23/h1-3,5-10,13-14,17,21H,4H2,(H,22,23)
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n/an/a 8n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475042
PNG
(US10849901, Compound 92)
Show SMILES OC(=O)c1ccccc1-c1cc(=O)n2nc(c(-c3ccc(Cl)cc3)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H11ClF3N3O3/c21-11-7-5-10(6-8-11)16-17(20(22,23)24)26-27-15(28)9-14(25-18(16)27)12-3-1-2-4-13(12)19(29)30/h1-9,25H,(H,29,30)
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n/an/a 8.10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475043
PNG
(US10849901, Compound 93)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(F)cc2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H13ClFN3O/c1-11-18(13-2-6-14(20)7-3-13)19-22-16(10-17(25)24(19)23-11)12-4-8-15(21)9-5-12/h2-10,22H,1H3
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n/an/a 8.20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475078
PNG
(US10849901, Compound 128)
Show SMILES Cn1cc(\C=C(/CC(O)=O)C2Nc3ccccc3S2)c(n1)-c1ccc2OCCCOc2c1
Show InChI InChI=1S/C24H23N3O4S/c1-27-14-17(23(26-27)15-7-8-19-20(12-15)31-10-4-9-30-19)11-16(13-22(28)29)24-25-18-5-2-3-6-21(18)32-24/h2-3,5-8,11-12,14,24-25H,4,9-10,13H2,1H3,(H,28,29)/b16-11+
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n/an/a 8.40n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475044
PNG
(US10849901, Compound 94)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H16N4O5S/c1-12-19(14-5-9-16(10-6-14)30(2,28)29)20-21-17(11-18(25)23(20)22-12)13-3-7-15(8-4-13)24(26)27/h3-11,21H,1-2H3
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n/an/a 8.80n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475045
PNG
(US10849901, Compound 95 | US10953012, Example 7)
Show SMILES O=c1cc([nH]c2c(c(Cc3ccccc3)nn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C25H19N3O/c29-23-17-21(19-12-6-2-7-13-19)26-25-24(20-14-8-3-9-15-20)22(27-28(23)25)16-18-10-4-1-5-11-18/h1-15,17,26H,16H2
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n/an/a 9.40n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475079
PNG
(US10849901, Compound 129)
Show SMILES Clc1ccc(cc1)-c1csc2[nH]c(=S)n(Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C19H13ClN2OS2/c20-14-8-6-13(7-9-14)15-11-25-17-16(15)18(23)22(19(24)21-17)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,21,24)
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n/an/a 9.70n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475080
PNG
(US10849901, Compound 130)
Show SMILES Cc1ccc(cn1)C(=O)OCc1cc(=O)n2cc(Br)ccc2n1
Show InChI InChI=1S/C16H12BrN3O3/c1-10-2-3-11(7-18-10)16(22)23-9-13-6-15(21)20-8-12(17)4-5-14(20)19-13/h2-8H,9H2,1H3
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n/an/a 9.90n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475046
PNG
(US10849901, Compound 96)
Show SMILES CCS(=O)(=O)Nc1ccc(cc1)-c1cc(=O)n2nc(C)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C21H19ClN4O3S/c1-3-30(28,29)25-17-10-6-14(7-11-17)18-12-19(27)26-21(23-18)20(13(2)24-26)15-4-8-16(22)9-5-15/h4-12,23,25H,3H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475050
PNG
(US10849901, Compound 100)
Show SMILES OC1C=C(Nc2cc(nn12)-c1cccc(Cl)c1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H13ClN4O3/c19-13-3-1-2-12(8-13)16-9-17-20-15(10-18(24)22(17)21-16)11-4-6-14(7-5-11)23(25)26/h1-10,18,20,24H
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n/an/a 10n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475081
PNG
(US10849901, Compound 131)
Show SMILES Cc1ccn2c(c1)nc(CSc1nc(C)cc(=O)[nH]1)cc2=O
Show InChI InChI=1S/C15H14N4O2S/c1-9-3-4-19-12(5-9)17-11(7-14(19)21)8-22-15-16-10(2)6-13(20)18-15/h3-7H,8H2,1-2H3,(H,16,18,20)
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n/an/a 11n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475047
PNG
(US10849901, Compound 97)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1cc(=O)n2nc(C)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C22H20ClN5O2/c1-3-24-22(30)25-17-10-6-14(7-11-17)18-12-19(29)28-21(26-18)20(13(2)27-28)15-4-8-16(23)9-5-15/h4-12,26H,3H2,1-2H3,(H2,24,25,30)
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n/an/a 11n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475049
PNG
(US10849901, Compound 99)
Show SMILES Clc1ccc(cc1)-c1c(Cc2ccccc2)nn2c1[nH]c(Cc1ccccc1)cc2=O
Show InChI InChI=1S/C26H20ClN3O/c27-21-13-11-20(12-14-21)25-23(16-19-9-5-2-6-10-19)29-30-24(31)17-22(28-26(25)30)15-18-7-3-1-4-8-18/h1-14,17,28H,15-16H2
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n/an/a 11n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475048
PNG
(US10849901, Compound 98)
Show SMILES Cc1c(Cc2ccccc2)nn2c1[nH]c(cc2=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C20H16N4O3/c1-13-17(11-14-5-3-2-4-6-14)22-23-19(25)12-18(21-20(13)23)15-7-9-16(10-8-15)24(26)27/h2-10,12,21H,11H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475050
PNG
(US10849901, Compound 100)
Show SMILES OC1C=C(Nc2cc(nn12)-c1cccc(Cl)c1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H13ClN4O3/c19-13-3-1-2-12(8-13)16-9-17-20-15(10-18(24)22(17)21-16)11-4-6-14(7-5-11)23(25)26/h1-10,18,20,24H
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n/an/a 13n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475051
PNG
(US10849901, Compound 101)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H13F3N4O4/c1-11-18(13-4-8-15(9-5-13)31-20(21,22)23)19-24-16(10-17(28)26(19)25-11)12-2-6-14(7-3-12)27(29)30/h2-10,24H,1H3
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n/an/a 13n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475083
PNG
(US10849901, Compound 133)
Show SMILES Cc1cc(nc2cc(nn12)C(=O)Nc1cc(Oc2cncc(Cl)c2)cc(c1)[N+]([O-])=O)-c1ccccc1
Show InChI InChI=1S/C25H17ClN6O4/c1-15-7-22(16-5-3-2-4-6-16)29-24-12-23(30-31(15)24)25(33)28-18-9-19(32(34)35)11-20(10-18)36-21-8-17(26)13-27-14-21/h2-14H,1H3,(H,28,33)
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n/an/a 13n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475084
PNG
(US10849901, Compound 134)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2ccccc2SCc2ccc(cc2)C#N)c(=O)[nH]c1=O
Show InChI InChI=1S/C22H18N4O5S/c1-26-19(24)18(20(28)25-22(26)30)16(27)11-31-21(29)15-4-2-3-5-17(15)32-12-14-8-6-13(10-23)7-9-14/h2-9H,11-12,24H2,1H3,(H,25,28,30)
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n/an/a 13n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475053
PNG
(US10849901, Compound 103)
Show SMILES Cc1nn2c([nH]c(cc2=O)C2CCCCC2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O/c1-12-18(14-7-9-15(20)10-8-14)19-21-16(11-17(24)23(19)22-12)13-5-3-2-4-6-13/h7-11,13,21H,2-6H2,1H3
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n/an/a 14n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475054
PNG
(US10849901, Compound 104)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(C3CC3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C21H15ClN4O3/c22-15-7-3-13(4-8-15)19-20(14-1-2-14)24-25-18(27)11-17(23-21(19)25)12-5-9-16(10-6-12)26(28)29/h3-11,14,23H,1-2H2
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n/an/a 14n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475052
PNG
(US10849901, Compound 102)
Show SMILES FC(F)(F)c1nn2c([nH]c(Cc3cccnc3)cc2=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H12ClF3N4O/c20-13-5-3-12(4-6-13)16-17(19(21,22)23)26-27-15(28)9-14(25-18(16)27)8-11-2-1-7-24-10-11/h1-7,9-10,25H,8H2
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Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475055
PNG
(US10849901, Compound 105)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(Cl)cc2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C19H13ClFN3O/c1-11-18(13-4-8-15(21)9-5-13)19-22-16(10-17(25)24(19)23-11)12-2-6-14(20)7-3-12/h2-10,22H,1H3
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n/an/a 15n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475085
PNG
(US10849901, Compound 135)
Show SMILES O=C1N(N=C(\C1=N/Nc1nc2ccccc2s1)c1ccccc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C25H16N6OS2/c32-23-22(28-29-24-26-18-13-7-8-14-20(18)34-24)21(17-11-5-2-6-12-17)30-31(23)25-27-19(15-33-25)16-9-3-1-4-10-16/h1-15H,(H,26,29)/b28-22+
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n/an/a 16n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475086
PNG
(US10849901, Compound 136)
Show SMILES Fc1ccc(cc1)C1CC(=NN1c1nc(cs1)-c1ccc(cc1)-c1ccccc1)c1cccs1
Show InChI InChI=1S/C28H20FN3S2/c29-23-14-12-22(13-15-23)26-17-24(27-7-4-16-33-27)31-32(26)28-30-25(18-34-28)21-10-8-20(9-11-21)19-5-2-1-3-6-19/h1-16,18,26H,17H2
PDB

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n/an/a 16n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475057
PNG
(US10849901, Compound 107)
Show SMILES OC(=O)c1ccc(cc1)-c1cc(=O)n2nc(C3CC3)c(-c3ccc(Cl)cc3)c2[nH]1
Show InChI InChI=1S/C22H16ClN3O3/c23-16-9-7-13(8-10-16)19-20(14-3-4-14)25-26-18(27)11-17(24-21(19)26)12-1-5-15(6-2-12)22(28)29/h1-2,5-11,14,24H,3-4H2,(H,28,29)
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n/an/a 16n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475058
PNG
(US10849901, Compound 108)
Show SMILES Clc1ccc(cc1)-c1c(nc2n1[nH]c(cc2=O)-c1ccc(cc1)C#N)C1CC1
Show InChI InChI=1S/C22H15ClN4O/c23-17-9-7-16(8-10-17)21-20(15-5-6-15)25-22-19(28)11-18(26-27(21)22)14-3-1-13(12-24)2-4-14/h1-4,7-11,15,26H,5-6H2
PDB

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n/an/a 16n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475056
PNG
(US10849901, Compound 106)
Show SMILES Cc1nn2c([nH]c(cc2=O)C2CCCC2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN3O/c1-11-17(13-6-8-14(19)9-7-13)18-20-15(12-4-2-3-5-12)10-16(23)22(18)21-11/h6-10,12,20H,2-5H2,1H3
PDB

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n/an/a 16n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475087
PNG
(US10849901, Compound 137)
Show SMILES CSc1nnc-2c(OC(Nc3ccccc-23)c2cc(O)ccc2[N+]([O-])=O)n1
Show InChI InChI=1S/C17H13N5O4S/c1-27-17-19-16-14(20-21-17)10-4-2-3-5-12(10)18-15(26-16)11-8-9(23)6-7-13(11)22(24)25/h2-8,15,18,23H,1H3
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n/an/a 17n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475088
PNG
(US10849901, Compound 138)
Show SMILES O=c1[nH]c(CSc2ncnc3sccc23)nc2ccsc12
Show InChI InChI=1S/C13H8N4OS3/c18-11-10-8(2-4-19-10)16-9(17-11)5-21-13-7-1-3-20-12(7)14-6-15-13/h1-4,6H,5H2,(H,16,17,18)
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n/an/a 17n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475052
PNG
(US10849901, Compound 102)
Show SMILES FC(F)(F)c1nn2c([nH]c(Cc3cccnc3)cc2=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H12ClF3N4O/c20-13-5-3-12(4-6-13)16-17(19(21,22)23)26-27-15(28)9-14(25-18(16)27)8-11-2-1-7-24-10-11/h1-7,9-10,25H,8H2
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n/an/a 17n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475059
PNG
(US10849901, Compound 109)
Show SMILES COc1ccc(cc1)-c1c(C)nn2c1[nH]c(cc2=O)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C20H16N4O4/c1-12-19(14-5-9-16(28-2)10-6-14)20-21-17(11-18(25)23(20)22-12)13-3-7-15(8-4-13)24(26)27/h3-11,21H,1-2H3
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n/an/a 17n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475060
PNG
(US10849901, Compound 110)
Show SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1C1CCCC1
Show InChI InChI=1S/C18H18N4O3/c1-11-17(13-4-2-3-5-13)18-19-15(10-16(23)21(18)20-11)12-6-8-14(9-7-12)22(24)25/h6-10,13,19H,2-5H2,1H3
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n/an/a 19n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475089
PNG
(US10849901, Compound 139)
Show SMILES Clc1ccc(SCCNC(=O)COC(=O)c2cc3ccccc3[nH]2)cc1
Show InChI InChI=1S/C19H17ClN2O3S/c20-14-5-7-15(8-6-14)26-10-9-21-18(23)12-25-19(24)17-11-13-3-1-2-4-16(13)22-17/h1-8,11,22H,9-10,12H2,(H,21,23)
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n/an/a 19n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475061
PNG
(US10849901, Compound 111)
Show SMILES FC(F)(F)c1nn2c([nH]c(cc2=O)-c2cccc(NC(=O)c3ccccc3)c2)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H16ClF3N4O2/c27-18-11-9-15(10-12-18)22-23(26(28,29)30)33-34-21(35)14-20(32-24(22)34)17-7-4-8-19(13-17)31-25(36)16-5-2-1-3-6-16/h1-14,32H,(H,31,36)
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n/an/a 20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475062
PNG
(US10849901, Compound 112)
Show SMILES Clc1ccc(cc1)-c1c(nn2c1[nH]c(cc2=O)-c1ccc(cc1)C#N)C1CCOCC1
Show InChI InChI=1S/C24H19ClN4O2/c25-19-7-5-17(6-8-19)22-23(18-9-11-31-12-10-18)28-29-21(30)13-20(27-24(22)29)16-3-1-15(14-26)2-4-16/h1-8,13,18,27H,9-12H2
PDB

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n/an/a 20n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475090
PNG
(US10849901, Compound 140)
Show SMILES Oc1ccc2c(c1)oc(c(-c1cccc3ccccc13)c2=O)C(F)(F)F
Show InChI InChI=1S/C20H11F3O3/c21-20(22,23)19-17(14-7-3-5-11-4-1-2-6-13(11)14)18(25)15-9-8-12(24)10-16(15)26-19/h1-10,24H
PDB

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n/an/a 29n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475082
PNG
(US10849901, Compound 132)
Show SMILES CCCc1cc(=O)[nH]c(SCc2cc(=O)n3cc(Br)ccc3n2)n1
Show InChI InChI=1S/C16H15BrN4O2S/c1-2-3-11-6-14(22)20-16(19-11)24-9-12-7-15(23)21-8-10(17)4-5-13(21)18-12/h4-8H,2-3,9H2,1H3,(H,19,20,22)
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n/an/a 30n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
ADP-ribosylation factor 6


(Human)
BDBM475091
PNG
(US10849901, Compound 141)
Show SMILES O=C1C(C(=O)c2ccccc12)C1=NC2C(Oc3ccccc23)S1
Show InChI InChI=1S/C18H11NO3S/c20-15-9-5-1-2-6-10(9)16(21)13(15)17-19-14-11-7-3-4-8-12(11)22-18(14)23-17/h1-8,13-14,18H
PDB

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n/an/a 31n/an/an/an/an/an/a



Navigen, Inc.; The University of Utah Research Foundation

US Patent


Assay Description
The primary biochemical assay uses a fluorometric assay for monitoring the replacement of bound nucleotide with a fluorogenic GTP derivative bearing ...


US Patent US10849901 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%