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Patent code US10851083

Compile Data Set for Download or QSAR
Found 186 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475561
PNG
(1-[6-Chloro-5-(4-chloro-phenylmethanesulfonyl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C18H12Cl2N4O4S/c19-12-3-1-10(2-4-12)9-29(27,28)16-6-15-14(5-13(16)20)22-18(23-15)24-8-11(7-21-24)17(25)26/h1-8H,9H2,(H,22,23)(H,25,26)
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n/an/a 15.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475567
PNG
(1-[6-Chloro-5-(4-trifluoromethyl-phenylmethanesulf...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H12ClF3N4O4S/c20-13-5-14-15(26-18(25-14)27-8-11(7-24-27)17(28)29)6-16(13)32(30,31)9-10-1-3-12(4-2-10)19(21,22)23/h1-8H,9H2,(H,25,26)(H,28,29)
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n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475569
PNG
(1-[6-Chloro-5-(2'-cyano-biphenyl-4-ylmethanesulfon...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C25H16ClN5O4S/c26-20-9-21-22(30-25(29-21)31-13-18(12-28-31)24(32)33)10-23(20)36(34,35)14-15-5-7-16(8-6-15)19-4-2-1-3-17(19)11-27/h1-10,12-13H,14H2,(H,29,30)(H,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475563
PNG
(1-(6-Chloro-5-cyclohexylmethanesulfonyl-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)CC1CCCCC1
Show InChI InChI=1S/C18H19ClN4O4S/c19-13-6-14-15(22-18(21-14)23-9-12(8-20-23)17(24)25)7-16(13)28(26,27)10-11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475479
PNG
(1-[6-Chloro-5-(4-methoxy-phenylmethanesulfonyl)-1H...)
Show SMILES COc1ccc(CS(=O)(=O)c2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C19H15ClN4O5S/c1-29-13-4-2-11(3-5-13)10-30(27,28)17-7-16-15(6-14(17)20)22-19(23-16)24-9-12(8-21-24)18(25)26/h2-9H,10H2,1H3,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475557
PNG
(1-[6-Chloro-5-(4-methyl-benzylsulfanyl)-1H- | US10...)
Show SMILES Cc1ccc(CS(=O)(=O)c2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C19H15ClN4O4S/c1-11-2-4-12(5-3-11)10-29(27,28)17-7-16-15(6-14(17)20)22-19(23-16)24-9-13(8-21-24)18(25)26/h2-9H,10H2,1H3,(H,22,23)(H,25,26)
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n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475564
PNG
(1-[6-Chloro-5-(3,4-dichloro-phenylmethanesulfonyl)...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H11Cl3N4O4S/c19-11-2-1-9(3-12(11)20)8-30(28,29)16-5-15-14(4-13(16)21)23-18(24-15)25-7-10(6-22-25)17(26)27/h1-7H,8H2,(H,23,24)(H,26,27)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475568
PNG
(1-[5-(2,4-Bis-trifluoromethyl-phenylmethanesulfony...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccc(cc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H11ClF6N4O4S/c21-13-4-14-15(30-18(29-14)31-7-10(6-28-31)17(32)33)5-16(13)36(34,35)8-9-1-2-11(19(22,23)24)3-12(9)20(25,26)27/h1-7H,8H2,(H,29,30)(H,32,33)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475549
PNG
(1-(5-Benzenesulfonyl-6-trifluoromethyl-1H- | US108...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(cc2[nH]1)C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H11F3N4O4S/c19-18(20,21)12-6-13-14(7-15(12)30(28,29)11-4-2-1-3-5-11)24-17(23-13)25-9-10(8-22-25)16(26)27/h1-9H,(H,23,24)(H,26,27)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475550
PNG
(1-[5-(4-Methoxy-benzenesulfonyl)-6-trifluoromethyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1cc2nc([nH]c2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C19H13F3N4O5S/c1-31-11-2-4-12(5-3-11)32(29,30)16-7-15-14(6-13(16)19(20,21)22)24-18(25-15)26-9-10(8-23-26)17(27)28/h2-9H,1H3,(H,24,25)(H,27,28)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475543
PNG
(1-(5-Ethylsulfonyl-6-trifluoromethoxy-1H-benzoimid...)
Show SMILES CCS(=O)(=O)c1cc2nc([nH]c2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H11F3N4O5S/c1-2-27(24,25)11-4-9-8(3-10(11)26-14(15,16)17)19-13(20-9)21-6-7(5-18-21)12(22)23/h3-6H,2H2,1H3,(H,19,20)(H,22,23)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475485
PNG
(1-(6-Methanesulfonyl-5-trifluoromethyl-1H- | US108...)
Show SMILES CS(=O)(=O)c1cc2[nH]c(nc2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H9F3N4O4S/c1-25(23,24)10-3-9-8(2-7(10)13(14,15)16)18-12(19-9)20-5-6(4-17-20)11(21)22/h2-5H,1H3,(H,18,19)(H,21,22)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475562
PNG
(1-[6-Chloro-5-(3-chloro-phenylmethanesulfonyl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1cccc(Cl)c1
Show InChI InChI=1S/C18H12Cl2N4O4S/c19-12-3-1-2-10(4-12)9-29(27,28)16-6-15-14(5-13(16)20)22-18(23-15)24-8-11(7-21-24)17(25)26/h1-8H,9H2,(H,22,23)(H,25,26)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475401
PNG
(1-{5-[3-(2-Chloro-benzyloxy)-phenyl]-1H-benzoimida...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1cccc(OCc2ccccc2Cl)c1
Show InChI InChI=1S/C24H17ClN4O3/c25-20-7-2-1-4-17(20)14-32-19-6-3-5-15(10-19)16-8-9-21-22(11-16)28-24(27-21)29-13-18(12-26-29)23(30)31/h1-13H,14H2,(H,27,28)(H,30,31)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475542
PNG
(1-(5-Ethylsulfonyl-6-trifluoromethyl-1H-benzoimida...)
Show SMILES CCS(=O)(=O)c1cc2nc([nH]c2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H11F3N4O4S/c1-2-26(24,25)11-4-10-9(3-8(11)14(15,16)17)19-13(20-10)21-6-7(5-18-21)12(22)23/h3-6H,2H2,1H3,(H,19,20)(H,22,23)
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n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475471
PNG
(1-(5-Benzenesulfonyl-6-chloro-1H-benzoimidazol-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H11ClN4O4S/c18-12-6-13-14(7-15(12)27(25,26)11-4-2-1-3-5-11)21-17(20-13)22-9-10(8-19-22)16(23)24/h1-9H,(H,20,21)(H,23,24)
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n/an/a 26.9n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475480
PNG
(1-[6-Chloro-5-(4-fluoro-phenylmethanesulfonyl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C18H12ClFN4O4S/c19-13-5-14-15(23-18(22-14)24-8-11(7-21-24)17(25)26)6-16(13)29(27,28)9-10-1-3-12(20)4-2-10/h1-8H,9H2,(H,22,23)(H,25,26)
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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475477
PNG
(1-(6-Chloro-5-phenylmethanesulfonyl-1H- | US108510...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C18H13ClN4O4S/c19-13-6-14-15(22-18(21-14)23-9-12(8-20-23)17(24)25)7-16(13)28(26,27)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,21,22)(H,24,25)
PDB

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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475428
PNG
(1-(6-Chloro-5-nitro-1H-benzoimidazol-2-yl)-1H-pyra...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)[N+]([O-])=O
Show InChI InChI=1S/C11H6ClN5O4/c12-6-1-7-8(2-9(6)17(20)21)15-11(14-7)16-4-5(3-13-16)10(18)19/h1-4H,(H,14,15)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475488
PNG
(1-(6-Methanesulfonyl-5-trifluoromethoxy-1H- | US10...)
Show SMILES CS(=O)(=O)c1cc2[nH]c(nc2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H9F3N4O5S/c1-26(23,24)10-3-8-7(2-9(10)25-13(14,15)16)18-12(19-8)20-5-6(4-17-20)11(21)22/h2-5H,1H3,(H,18,19)(H,21,22)
PDB

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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475492
PNG
(1-[6-(Propane-1-sulfonyl)-5-trifluoromethyl-1H- | ...)
Show SMILES CCCS(=O)(=O)c1cc2[nH]c(nc2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O4S/c1-2-3-27(25,26)12-5-11-10(4-9(12)15(16,17)18)20-14(21-11)22-7-8(6-19-22)13(23)24/h4-7H,2-3H2,1H3,(H,20,21)(H,23,24)
PDB

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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475494
PNG
(1-[6-(Propane-1-sulfonyl)-5-trifluoromethoxy-1H- |...)
Show SMILES CCCS(=O)(=O)c1cc2[nH]c(nc2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O5S/c1-2-3-28(25,26)12-5-10-9(4-11(12)27-15(16,17)18)20-14(21-10)22-7-8(6-19-22)13(23)24/h4-7H,2-3H2,1H3,(H,20,21)(H,23,24)
PDB

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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475548
PNG
(1-[5-(4-Methoxy-phenylsulfanyl)-6-trifluoromethyl-...)
Show SMILES COc1ccc(Sc2cc3nc([nH]c3cc2C(F)(F)F)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C19H13F3N4O3S/c1-29-11-2-4-12(5-3-11)30-16-7-15-14(6-13(16)19(20,21)22)24-18(25-15)26-9-10(8-23-26)17(27)28/h2-9H,1H3,(H,24,25)(H,27,28)
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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475443
PNG
(1-[5-(4-Chloro-phenoxy)-6-trifluoromethyl-1H- | US...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(Cl)cc3)c(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C18H10ClF3N4O3/c19-10-1-3-11(4-2-10)29-15-6-14-13(5-12(15)18(20,21)22)24-17(25-14)26-8-9(7-23-26)16(27)28/h1-8H,(H,24,25)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475481
PNG
(1-[6-Chloro-5-(2-chloro-phenylmethanesulfonyl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1ccccc1Cl
Show InChI InChI=1S/C18H12Cl2N4O4S/c19-12-4-2-1-3-10(12)9-29(27,28)16-6-15-14(5-13(16)20)22-18(23-15)24-8-11(7-21-24)17(25)26/h1-8H,9H2,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475560
PNG
(1-[6-Chloro-5-(2'-cyano-biphenyl-4-ylmethylsulfany...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccc(cc3)-c3ccccc3C#N)c(Cl)cc2[nH]1
Show InChI InChI=1S/C25H16ClN5O2S/c26-20-9-21-22(30-25(29-21)31-13-18(12-28-31)24(32)33)10-23(20)34-14-15-5-7-16(8-6-15)19-4-2-1-3-17(19)11-27/h1-10,12-13H,14H2,(H,29,30)(H,32,33)
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n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475490
PNG
(1-[5-Chloro-6-(propane-1-sulfonyl)-1H-benzoimidazo...)
Show SMILES CCCS(=O)(=O)c1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13ClN4O4S/c1-2-3-24(22,23)12-5-11-10(4-9(12)15)17-14(18-11)19-7-8(6-16-19)13(20)21/h4-7H,2-3H2,1H3,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475400
PNG
(1-{5-[3-(3-Chloro-benzyloxy)-phenyl]-1H-benzoimida...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1cccc(OCc2cccc(Cl)c2)c1
Show InChI InChI=1S/C24H17ClN4O3/c25-19-5-1-3-15(9-19)14-32-20-6-2-4-16(10-20)17-7-8-21-22(11-17)28-24(27-21)29-13-18(12-26-29)23(30)31/h1-13H,14H2,(H,27,28)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475565
PNG
(1-[6-Chloro-5-(2,6-dichloro-phenylmethanesulfonyl)...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H11Cl3N4O4S/c19-11-2-1-3-12(20)10(11)8-30(28,29)16-5-15-14(4-13(16)21)23-18(24-15)25-7-9(6-22-25)17(26)27/h1-7H,8H2,(H,23,24)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475535
PNG
(1-[6-Chloro-5-(4-trifluoromethoxy-phenoxy)-1H- | U...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(OC(F)(F)F)cc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H10ClF3N4O4/c19-12-5-13-14(25-17(24-13)26-8-9(7-23-26)16(27)28)6-15(12)29-10-1-3-11(4-2-10)30-18(20,21)22/h1-8H,(H,24,25)(H,27,28)
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n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475574
PNG
(1-(6-Chloro-5-phenylsulfamoyl-1H-benzoimidazol-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C17H12ClN5O4S/c18-12-6-13-14(21-17(20-13)23-9-10(8-19-23)16(24)25)7-15(12)28(26,27)22-11-4-2-1-3-5-11/h1-9,22H,(H,20,21)(H,24,25)
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n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475545
PNG
(1-(6-Fluoro-5-propylsulfonyl-1H-benzoimidazol-2-yl...)
Show SMILES CCCS(=O)(=O)c1cc2nc([nH]c2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13FN4O4S/c1-2-3-24(22,23)12-5-11-10(4-9(12)15)17-14(18-11)19-7-8(6-16-19)13(20)21/h4-7H,2-3H2,1H3,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475438
PNG
(1-[5-(3,4-Dichloro-phenoxy)-6-trifluoromethyl-1H- ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(Cl)c(Cl)c3)c(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C18H9Cl2F3N4O3/c19-11-2-1-9(3-12(11)20)30-15-5-14-13(4-10(15)18(21,22)23)25-17(26-14)27-7-8(6-24-27)16(28)29/h1-7H,(H,25,26)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475491
PNG
(1-[6-(Propane-2-sulfonyl)-5-trifluoromethyl-1H- | ...)
Show SMILES CC(C)S(=O)(=O)c1cc2[nH]c(nc2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O4S/c1-7(2)27(25,26)12-4-11-10(3-9(12)15(16,17)18)20-14(21-11)22-6-8(5-19-22)13(23)24/h3-7H,1-2H3,(H,20,21)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475427
PNG
(1-(6-Chloro-5-cyano-1H-benzoimidazol-2-yl)-1H- | U...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(C#N)c(Cl)cc2[nH]1
Show InChI InChI=1S/C12H6ClN5O2/c13-8-2-10-9(1-6(8)3-14)16-12(17-10)18-5-7(4-15-18)11(19)20/h1-2,4-5H,(H,16,17)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475544
PNG
(1-(5-Ethylsulfonyl-6-fluoro-1H-benzoimidazol-2-yl)...)
Show SMILES CCS(=O)(=O)c1cc2nc([nH]c2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H11FN4O4S/c1-2-23(21,22)11-4-10-9(3-8(11)14)16-13(17-10)18-6-7(5-15-18)12(19)20/h3-6H,2H2,1H3,(H,16,17)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475487
PNG
(1-(5-Chloro-6-methanesulfonyl-1H-benzoimidazol-2-y...)
Show SMILES CS(=O)(=O)c1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9ClN4O4S/c1-22(20,21)10-3-9-8(2-7(10)13)15-12(16-9)17-5-6(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475482
PNG
(1-[6-Chloro-5-(2-phenyl-ethanesulfonyl)-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)CCc1ccccc1
Show InChI InChI=1S/C19H15ClN4O4S/c20-14-8-15-16(23-19(22-15)24-11-13(10-21-24)18(25)26)9-17(14)29(27,28)7-6-12-4-2-1-3-5-12/h1-5,8-11H,6-7H2,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475402
PNG
(1-{5-[3-(4-Chloro-benzyloxy)-phenyl]-1H-benzoimida...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1cccc(OCc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H17ClN4O3/c25-19-7-4-15(5-8-19)14-32-20-3-1-2-16(10-20)17-6-9-21-22(11-17)28-24(27-21)29-13-18(12-26-29)23(30)31/h1-13H,14H2,(H,27,28)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475439
PNG
(1-[6-Chloro-5-(4-chloro-phenoxy)-1H-benzoimidazol-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(Cl)cc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H10Cl2N4O3/c18-10-1-3-11(4-2-10)26-15-6-14-13(5-12(15)19)21-17(22-14)23-8-9(7-20-23)16(24)25/h1-8H,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475440
PNG
(1-[5-(4-Chloro-phenoxy)-6-trifluoromethoxy-1H- | U...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(Cl)cc3)c(OC(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C18H10ClF3N4O4/c19-10-1-3-11(4-2-10)29-14-5-12-13(6-15(14)30-18(20,21)22)25-17(24-12)26-8-9(7-23-26)16(27)28/h1-8H,(H,24,25)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475476
PNG
(1-[6-Chloro-5-(3-methoxy-benzenesulfonyl)-1H- | US...)
Show SMILES COc1cccc(c1)S(=O)(=O)c1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H13ClN4O5S/c1-28-11-3-2-4-12(5-11)29(26,27)16-7-15-14(6-13(16)19)21-18(22-15)23-9-10(8-20-23)17(24)25/h2-9H,1H3,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475470
PNG
(1-[6-Chloro-5-(toluene-3-sulfonyl)-1H-benzoimidazo...)
Show SMILES Cc1cccc(c1)S(=O)(=O)c1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H13ClN4O4S/c1-10-3-2-4-12(5-10)28(26,27)16-7-15-14(6-13(16)19)21-18(22-15)23-9-11(8-20-23)17(24)25/h2-9H,1H3,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475493
PNG
(1-[6-(Propane-2-sulfonyl)-5-trifluoromethoxy-1H- |...)
Show SMILES CC(C)S(=O)(=O)c1cc2[nH]c(nc2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O5S/c1-7(2)28(25,26)12-4-10-9(3-11(12)27-15(16,17)18)20-14(21-10)22-6-8(5-19-22)13(23)24/h3-7H,1-2H3,(H,20,21)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475514
PNG
(1-(5,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H6F6N4O2/c14-12(15,16)6-1-8-9(2-7(6)13(17,18)19)22-11(21-8)23-4-5(3-20-23)10(24)25/h1-4H,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475484
PNG
(1-(5-Chloro-6-ethanesulfonyl-1H-benzoimidazol-2-yl...)
Show SMILES CCS(=O)(=O)c1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H11ClN4O4S/c1-2-23(21,22)11-4-10-9(3-8(11)14)16-13(17-10)18-6-7(5-15-18)12(19)20/h3-6H,2H2,1H3,(H,16,17)(H,19,20)
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n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475547
PNG
(1-(5-Phenylsulfanyl-6-trifluoromethyl-1H-benzoimid...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Sc3ccccc3)c(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C18H11F3N4O2S/c19-18(20,21)12-6-13-14(7-15(12)28-11-4-2-1-3-5-11)24-17(23-13)25-9-10(8-22-25)16(26)27/h1-9H,(H,23,24)(H,26,27)
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n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475556
PNG
(1-[6-Chloro-5-(2,6-dichloro-benzylsulfanyl)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3c(Cl)cccc3Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H11Cl3N4O2S/c19-11-2-1-3-12(20)10(11)8-28-16-5-15-14(4-13(16)21)23-18(24-15)25-7-9(6-22-25)17(26)27/h1-7H,8H2,(H,23,24)(H,26,27)
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n/an/a 50.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475496
PNG
(1-(6-Methanesulfinyl-5-trifluoromethyl-1H- | US108...)
Show SMILES CS(=O)c1cc2[nH]c(nc2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475478
PNG
(1-[6-Chloro-5-(2,4,6-trimethyl-phenylmethanesulfon...)
Show SMILES Cc1cc(C)c(CS(=O)(=O)c2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)c(C)c1
Show InChI InChI=1S/C21H19ClN4O4S/c1-11-4-12(2)15(13(3)5-11)10-31(29,30)19-7-18-17(6-16(19)22)24-21(25-18)26-9-14(8-23-26)20(27)28/h4-9H,10H2,1-3H3,(H,24,25)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475403
PNG
(1-[5-(3-Benzyloxy-phenyl)-1H-benzoimidazol-2-yl]-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C24H18N4O3/c29-23(30)19-13-25-28(14-19)24-26-21-10-9-18(12-22(21)27-24)17-7-4-8-20(11-17)31-15-16-5-2-1-3-6-16/h1-14H,15H2,(H,26,27)(H,29,30)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475489
PNG
(1-[5-Chloro-6-(propane-2-sulfonyl)-1H-benzoimidazo...)
Show SMILES CC(C)S(=O)(=O)c1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13ClN4O4S/c1-7(2)24(22,23)12-4-11-10(3-9(12)15)17-14(18-11)19-6-8(5-16-19)13(20)21/h3-7H,1-2H3,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475442
PNG
(1-[5-(4-Fluoro-phenoxy)-6-trifluoromethyl-1H- | US...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(F)cc3)c(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C18H10F4N4O3/c19-10-1-3-11(4-2-10)29-15-6-14-13(5-12(15)18(20,21)22)24-17(25-14)26-8-9(7-23-26)16(27)28/h1-8H,(H,24,25)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475472
PNG
(1-[6-Chloro-5-(4-methoxy-benzenesulfonyl)-1H- | US...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C18H13ClN4O5S/c1-28-11-2-4-12(5-3-11)29(26,27)16-7-15-14(6-13(16)19)21-18(22-15)23-9-10(8-20-23)17(24)25/h2-9H,1H3,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475473
PNG
(1-[6-Chloro-5-(4-chloro-benzenesulfonyl)-1H- | US1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H10Cl2N4O4S/c18-10-1-3-11(4-2-10)28(26,27)15-6-14-13(5-12(15)19)21-17(22-14)23-8-9(7-20-23)16(24)25/h1-8H,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475546
PNG
(1-(6-Fluoro-5-isopropylsulfonyl-1H-benzoimidazol-2...)
Show SMILES CC(C)S(=O)(=O)c1cc2nc([nH]c2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13FN4O4S/c1-7(2)24(22,23)12-4-11-10(3-9(12)15)17-14(18-11)19-6-8(5-16-19)13(20)21/h3-7H,1-2H3,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475474
PNG
(1-[6-Chloro-5-(4-trifluoromethoxy-benzenesulfonyl)...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H10ClF3N4O5S/c19-12-5-13-14(25-17(24-13)26-8-9(7-23-26)16(27)28)6-15(12)32(29,30)11-3-1-10(2-4-11)31-18(20,21)22/h1-8H,(H,24,25)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475537
PNG
(1-(5-Ethylsulfanyl-6-trifluoromethyl-1H-benzoimida...)
Show SMILES CCSc1cc2nc([nH]c2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H11F3N4O2S/c1-2-24-11-4-10-9(3-8(11)14(15,16)17)19-13(20-10)21-6-7(5-18-21)12(22)23/h3-6H,2H2,1H3,(H,19,20)(H,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475486
PNG
(1-(5-Fluoro-6-methanesulfonyl-1H-benzoimidazol-2-y...)
Show SMILES CS(=O)(=O)c1cc2[nH]c(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9FN4O4S/c1-22(20,21)10-3-9-8(2-7(10)13)15-12(16-9)17-5-6(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475534
PNG
(1-[6-Chloro-5-(4-chloro-2-fluoro-phenoxy)-1H- | US...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(Cl)cc3F)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H9Cl2FN4O3/c18-9-1-2-14(11(20)3-9)27-15-5-13-12(4-10(15)19)22-17(23-13)24-7-8(6-21-24)16(25)26/h1-7H,(H,22,23)(H,25,26)
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n/an/a 63.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475455
PNG
(1-[5-(4-tert-Butyl-benzylsulfanyl)-6-chloro-1H- | ...)
Show SMILES CC(C)(C)c1ccc(CSc2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C22H21ClN4O2S/c1-22(2,3)15-6-4-13(5-7-15)12-30-19-9-18-17(8-16(19)23)25-21(26-18)27-11-14(10-24-27)20(28)29/h4-11H,12H2,1-3H3,(H,25,26)(H,28,29)
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n/an/a 63.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475444
PNG
(1-(5-Phenoxy-6-trifluoromethyl-1H-benzoimidazol-2-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccccc3)c(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C18H11F3N4O3/c19-18(20,21)12-6-13-14(7-15(12)28-11-4-2-1-3-5-11)24-17(23-13)25-9-10(8-22-25)16(26)27/h1-9H,(H,23,24)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475538
PNG
(1-(5-Ethylsulfanyl-6-trifluoromethoxy-1H-benzoimid...)
Show SMILES CCSc1cc2nc([nH]c2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H11F3N4O3S/c1-2-25-11-4-9-8(3-10(11)24-14(15,16)17)19-13(20-9)21-6-7(5-18-21)12(22)23/h3-6H,2H2,1H3,(H,19,20)(H,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475483
PNG
(1-(5-Chloro-6-ethanesulfinyl-1H-benzoimidazol-2-yl...)
Show SMILES CCS(=O)c1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475461
PNG
(1-(6-Isopropylsulfanyl-5-trifluoromethyl-1H- | US1...)
Show SMILES CC(C)Sc1cc2[nH]c(nc2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O2S/c1-7(2)25-12-4-11-10(3-9(12)15(16,17)18)20-14(21-11)22-6-8(5-19-22)13(23)24/h3-7H,1-2H3,(H,20,21)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475441
PNG
(1-(5-Phenoxy-6-trifluoromethoxy-1H-benzoimidazol-2...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccccc3)c(OC(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C18H11F3N4O4/c19-18(20,21)29-15-7-13-12(6-14(15)28-11-4-2-1-3-5-11)23-17(24-13)25-9-10(8-22-25)16(26)27/h1-9H,(H,23,24)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475495
PNG
(1-(5-Benzenesulfinyl-6-chloro-1H-benzoimidazol-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)c1ccc(Cl)cc1
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475446
PNG
(1-(5-Bromo-7-methyl-1H-imidazo[4,5-f]quinolin-2-yl...)
Show SMILES Cc1ccc2c3[nH]c(nc3cc(Br)c2n1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H10BrN5O2/c1-7-2-3-9-12(18-7)10(16)4-11-13(9)20-15(19-11)21-6-8(5-17-21)14(22)23/h2-6H,1H3,(H,19,20)(H,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM50418047
PNG
(CHEMBL1688407 | US10851083, Example 30)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C12H6ClF3N4O2/c13-7-2-9-8(1-6(7)12(14,15)16)18-11(19-9)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
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n/an/a 72.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475536
PNG
(1-[6-Chloro-5-(3-chloro-4-fluoro-phenoxy)-1H- | US...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccc(F)c(Cl)c3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H9Cl2FN4O3/c18-10-3-9(1-2-12(10)20)27-15-5-14-13(4-11(15)19)22-17(23-14)24-7-8(6-21-24)16(25)26/h1-7H,(H,22,23)(H,25,26)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475406
PNG
(1-[5-(3,4-Dichloro-phenyl)-1H-benzoimidazol-2-yl]-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H10Cl2N4O2/c18-12-3-1-9(5-13(12)19)10-2-4-14-15(6-10)22-17(21-14)23-8-11(7-20-23)16(24)25/h1-8H,(H,21,22)(H,24,25)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475405
PNG
(1-[5-(3-Trifluoromethyl-phenyl)-1H-benzoimidazol-2...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H11F3N4O2/c19-18(20,21)13-3-1-2-10(6-13)11-4-5-14-15(7-11)24-17(23-14)25-9-12(8-22-25)16(26)27/h1-9H,(H,23,24)(H,26,27)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475516
PNG
(1-(4-Bromo-5,6-dichloro-1H-benzoimidazol-2-yl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Br)c(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C11H5BrCl2N4O2/c12-7-8(14)5(13)1-6-9(7)17-11(16-6)18-3-4(2-15-18)10(19)20/h1-3H,(H,16,17)(H,19,20)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475426
PNG
(1-(6-Methanesulfonyl-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES CS(=O)(=O)c1ccc2nc([nH]c2c1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H10N4O4S/c1-21(19,20)8-2-3-9-10(4-8)15-12(14-9)16-6-7(5-13-16)11(17)18/h2-6H,1H3,(H,14,15)(H,17,18)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475533
PNG
(1-[6-Chloro-5-(4-methoxy-phenoxy)-1H-benzoimidazol...)
Show SMILES COc1ccc(Oc2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C18H13ClN4O4/c1-26-11-2-4-12(5-3-11)27-16-7-15-14(6-13(16)19)21-18(22-15)23-9-10(8-20-23)17(24)25/h2-9H,1H3,(H,21,22)(H,24,25)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475467
PNG
(1-(6-Methylsulfanyl-5-trifluoromethoxy-1H- | US108...)
Show SMILES CSc1cc2[nH]c(nc2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H9F3N4O3S/c1-24-10-3-8-7(2-9(10)23-13(14,15)16)18-12(19-8)20-5-6(4-17-20)11(21)22/h2-5H,1H3,(H,18,19)(H,21,22)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475460
PNG
(1-(6-Propylsulfanyl-5-trifluoromethyl-1H-benzoimid...)
Show SMILES CCCSc1cc2[nH]c(nc2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O2S/c1-2-3-25-12-5-11-10(4-9(12)15(16,17)18)20-14(21-11)22-7-8(6-19-22)13(23)24/h4-7H,2-3H2,1H3,(H,20,21)(H,23,24)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475459
PNG
(1-(6-Methylsulfanyl-5-trifluoromethyl-1H-benzoimid...)
Show SMILES CSc1cc2[nH]c(nc2cc1C(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H9F3N4O2S/c1-23-10-3-9-8(2-7(10)13(14,15)16)18-12(19-9)20-5-6(4-17-20)11(21)22/h2-5H,1H3,(H,18,19)(H,21,22)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475509
PNG
(1-(5-Benzylcarbamoyl-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H15N5O3/c25-17(20-9-12-4-2-1-3-5-12)13-6-7-15-16(8-13)23-19(22-15)24-11-14(10-21-24)18(26)27/h1-8,10-11H,9H2,(H,20,25)(H,22,23)(H,26,27)
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n/an/a 79.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475449
PNG
(1-[6-Chloro-5-(4-chloro-phenylsulfanyl)-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Sc3ccc(Cl)cc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H10Cl2N4O2S/c18-10-1-3-11(4-2-10)26-15-6-14-13(5-12(15)19)21-17(22-14)23-8-9(7-20-23)16(24)25/h1-8H,(H,21,22)(H,24,25)
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n/an/a 85.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475463
PNG
(1-(5-Chloro-6-methylsulfanyl-1H-benzoimidazol-2-yl...)
Show SMILES CSc1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9ClN4O2S/c1-20-10-3-9-8(2-7(10)13)15-12(16-9)17-5-6(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475469
PNG
(1-(6-Propylsulfanyl-5-trifluoromethoxy-1H- | US108...)
Show SMILES CCCSc1cc2[nH]c(nc2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O3S/c1-2-3-26-12-5-10-9(4-11(12)25-15(16,17)18)20-14(21-10)22-7-8(6-19-22)13(23)24/h4-7H,2-3H2,1H3,(H,20,21)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475554
PNG
(1-[6-Chloro-5-(2-morpholin-4-yl-ethylsulfanyl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCCN3CCOCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H18ClN5O3S/c18-12-7-13-14(8-15(12)27-6-3-22-1-4-26-5-2-22)21-17(20-13)23-10-11(9-19-23)16(24)25/h7-10H,1-6H2,(H,20,21)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM50418048
PNG
(CHEMBL1688408 | US10851083, Example 129)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(F)cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C12H6F4N4O2/c13-7-2-9-8(1-6(7)12(14,15)16)18-11(19-9)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475468
PNG
(1-(6-Isopropylsulfanyl-5-trifluoromethoxy-1H- | US...)
Show SMILES CC(C)Sc1cc2[nH]c(nc2cc1OC(F)(F)F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C15H13F3N4O3S/c1-7(2)26-12-4-10-9(3-11(12)25-15(16,17)18)20-14(21-10)22-6-8(5-19-22)13(23)24/h3-7H,1-2H3,(H,20,21)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475419
PNG
(1-(4,5,6-Trifluoro-1H-benzoimidazol-2-yl)-1H-pyraz...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(F)c(F)c(F)cc2[nH]1
Show InChI InChI=1S/C11H5F3N4O2/c12-5-1-6-9(8(14)7(5)13)17-11(16-6)18-3-4(2-15-18)10(19)20/h1-3H,(H,16,17)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475466
PNG
(1-(5-Chloro-6-propylsulfanyl-1H-benzoimidazol-2-yl...)
Show SMILES CCCSc1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13ClN4O2S/c1-2-3-22-12-5-11-10(4-9(12)15)17-14(18-11)19-7-8(6-16-19)13(20)21/h4-7H,2-3H2,1H3,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475501
PNG
(1-(6-Chloro-5-trifluoromethoxy-1H-benzoimidazol-2-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(OC(F)(F)F)c(Cl)cc2[nH]1
Show InChI InChI=1S/C12H6ClF3N4O3/c13-6-1-7-8(2-9(6)23-12(14,15)16)19-11(18-7)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
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n/an/a 105n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475464
PNG
(1-(5-Chloro-6-ethylsulfanyl-1H-benzoimidazol-2-yl)...)
Show SMILES CCSc1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H11ClN4O2S/c1-2-21-11-4-10-9(3-8(11)14)16-13(17-10)18-6-7(5-15-18)12(19)20/h3-6H,2H2,1H3,(H,16,17)(H,19,20)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475508
PNG
(1-(5-Phenylcarbamoyl-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H13N5O3/c24-16(20-13-4-2-1-3-5-13)11-6-7-14-15(8-11)22-18(21-14)23-10-12(9-19-23)17(25)26/h1-10H,(H,20,24)(H,21,22)(H,25,26)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475390
PNG
(1-(5,6-Dichloro-1H-benzoimidazol-2-yl)-1H-pyrazole...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C11H6Cl2N4O2/c12-6-1-8-9(2-7(6)13)16-11(15-8)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475515
PNG
(1-(4,5,6-Trichloro-1H-benzoimidazol-2-yl)-1H-pyraz...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Cl)c(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C11H5Cl3N4O2/c12-5-1-6-9(8(14)7(5)13)17-11(16-6)18-3-4(2-15-18)10(19)20/h1-3H,(H,16,17)(H,19,20)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475521
PNG
(1-(6-Chloro-5-phenylamino-1H-benzoimidazol-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Nc3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H12ClN5O2/c18-12-6-14-15(7-13(12)20-11-4-2-1-3-5-11)22-17(21-14)23-9-10(8-19-23)16(24)25/h1-9,20H,(H,21,22)(H,24,25)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475539
PNG
(1-(5-Ethylsulfanyl-6-fluoro-1H-benzoimidazol-2-yl)...)
Show SMILES CCSc1cc2nc([nH]c2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H11FN4O2S/c1-2-21-11-4-10-9(3-8(11)14)16-13(17-10)18-6-7(5-15-18)12(19)20/h3-6H,2H2,1H3,(H,16,17)(H,19,20)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475540
PNG
(1-(6-Fluoro-5-propylsulfanyl-1H-benzoimidazol-2-yl...)
Show SMILES CCCSc1cc2nc([nH]c2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13FN4O2S/c1-2-3-22-12-5-11-10(4-9(12)15)17-14(18-11)19-7-8(6-16-19)13(20)21/h4-7H,2-3H2,1H3,(H,17,18)(H,20,21)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475541
PNG
(1-(6-Fluoro-5-isopropylsulfanyl-1H-benzoimidazol-2...)
Show SMILES CC(C)Sc1cc2nc([nH]c2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13FN4O2S/c1-7(2)22-12-4-11-10(3-9(12)15)17-14(18-11)19-6-8(5-16-19)13(20)21/h3-7H,1-2H3,(H,17,18)(H,20,21)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475462
PNG
(1-(5-Fluoro-6-methylsulfanyl-1H-benzoimidazol-2-yl...)
Show SMILES CSc1cc2[nH]c(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9FN4O2S/c1-20-10-3-9-8(2-7(10)13)15-12(16-9)17-5-6(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475553
PNG
(1-(6-Chloro-5-cyclohexylmethylsulfanyl-1H- | US108...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCC3CCCCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H19ClN4O2S/c19-13-6-14-15(7-16(13)26-10-11-4-2-1-3-5-11)22-18(21-14)23-9-12(8-20-23)17(24)25/h6-9,11H,1-5,10H2,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475445
PNG
(1-(6-Chloro-5-phenoxy-1H-benzoimidazol-2-yl)-1H- |...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Oc3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H11ClN4O3/c18-12-6-13-14(7-15(12)25-11-4-2-1-3-5-11)21-17(20-13)22-9-10(8-19-22)16(23)24/h1-9H,(H,20,21)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475448
PNG
(1-(6-Chloro-5-m-tolylsulfanyl-1H-benzoimidazol-2-y...)
Show SMILES Cc1cccc(Sc2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)c1
Show InChI InChI=1S/C18H13ClN4O2S/c1-10-3-2-4-12(5-10)26-16-7-15-14(6-13(16)19)21-18(22-15)23-9-11(8-20-23)17(24)25/h2-9H,1H3,(H,21,22)(H,24,25)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475452
PNG
(1-[6-Chloro-5-(3-methoxy-phenylsulfanyl)-1H- | US1...)
Show SMILES COc1cccc(Sc2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)c1
Show InChI InChI=1S/C18H13ClN4O3S/c1-26-11-3-2-4-12(5-11)27-16-7-15-14(6-13(16)19)21-18(22-15)23-9-10(8-20-23)17(24)25/h2-9H,1H3,(H,21,22)(H,24,25)
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n/an/a 126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475500
PNG
(1-(4,6-Difluoro-1H-benzoimidazol-2-yl)-1H-pyrazole...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(F)cc(F)cc2[nH]1
Show InChI InChI=1S/C11H6F2N4O2/c12-6-1-7(13)9-8(2-6)15-11(16-9)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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n/an/a 158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475506
PNG
(1-(5-Fluoro-6-piperidin-1-yl-1H-benzoimidazol-2-yl...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(F)c(cc2[nH]1)N1CCCCC1
Show InChI InChI=1S/C16H16FN5O2/c17-11-6-12-13(7-14(11)21-4-2-1-3-5-21)20-16(19-12)22-9-10(8-18-22)15(23)24/h6-9H,1-5H2,(H,19,20)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475396
PNG
(1-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Cl)cc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C12H6ClF3N4O2/c13-7-1-6(12(14,15)16)2-8-9(7)19-11(18-8)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
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n/an/a 158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475417
PNG
(1-(7-Bromo-5-trifluoromethoxy-1H-benzoimidazol-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(OC(F)(F)F)cc(Br)c2[nH]1
Show InChI InChI=1S/C12H6BrF3N4O3/c13-7-1-6(23-12(14,15)16)2-8-9(7)19-11(18-8)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
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n/an/a 158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475465
PNG
(1-(5-Chloro-6-isopropylsulfanyl-1H-benzoimidazol-2...)
Show SMILES CC(C)Sc1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H13ClN4O2S/c1-7(2)22-12-4-11-10(3-9(12)15)17-14(18-11)19-6-8(5-16-19)13(20)21/h3-7H,1-2H3,(H,17,18)(H,20,21)
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n/an/a 158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475457
PNG
(1-[6-Chloro-5-(2-chloro-benzylsulfanyl)-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccccc3Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H12Cl2N4O2S/c19-12-4-2-1-3-10(12)9-27-16-6-15-14(5-13(16)20)22-18(23-15)24-8-11(7-21-24)17(25)26/h1-8H,9H2,(H,22,23)(H,25,26)
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n/an/a 158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475524
PNG
(1-(6-Chloro-5-methanesulfonylamino-1H-benzoimidazo...)
Show SMILES CS(=O)(=O)Nc1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H10ClN5O4S/c1-23(21,22)17-8-3-10-9(2-7(8)13)15-12(16-10)18-5-6(4-14-18)11(19)20/h2-5,17H,1H3,(H,15,16)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475423
PNG
(1-(4-Bromo-6-trifluoromethyl-1H-benzoimidazol-2-yl...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Br)cc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C12H6BrF3N4O2/c13-7-1-6(12(14,15)16)2-8-9(7)19-11(18-8)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
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n/an/a 158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475456
PNG
(1-[6-Chloro-5-(4-fluoro-benzylsulfanyl)-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccc(F)cc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H12ClFN4O2S/c19-13-5-14-15(6-16(13)27-9-10-1-3-12(20)4-2-10)23-18(22-14)24-8-11(7-21-24)17(25)26/h1-8H,9H2,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475523
PNG
(1-(6-Chloro-5-cyclopropanesulfonylamino-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(NS(=O)(=O)C3CC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C14H12ClN5O4S/c15-9-3-11-12(4-10(9)19-25(23,24)8-1-2-8)18-14(17-11)20-6-7(5-16-20)13(21)22/h3-6,8,19H,1-2H2,(H,17,18)(H,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475526
PNG
(1-(5-Benzenesulfonylamino-6-chloro-1H-benzoimidazo...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(NS(=O)(=O)c3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H12ClN5O4S/c18-12-6-14-15(21-17(20-14)23-9-10(8-19-23)16(24)25)7-13(12)22-28(26,27)11-4-2-1-3-5-11/h1-9,22H,(H,20,21)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475450
PNG
(1-(6-Chloro-5-phenylsulfanyl-1H-benzoimidazol-2-yl...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Sc3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H11ClN4O2S/c18-12-6-13-14(7-15(12)25-11-4-2-1-3-5-11)21-17(20-13)22-9-10(8-19-22)16(23)24/h1-9H,(H,20,21)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475432
PNG
(1-(6-Chloro-5-piperidin-1-yl-1H-benzoimidazol-2-yl...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(N3CCCCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C16H16ClN5O2/c17-11-6-12-13(7-14(11)21-4-2-1-3-5-21)20-16(19-12)22-9-10(8-18-22)15(23)24/h6-9H,1-5H2,(H,19,20)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475454
PNG
(1-(5-Benzylsulfanyl-6-chloro-1H-benzoimidazol-2-yl...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H13ClN4O2S/c19-13-6-14-15(7-16(13)26-10-11-4-2-1-3-5-11)22-18(21-14)23-9-12(8-20-23)17(24)25/h1-9H,10H2,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475558
PNG
(1-[6-Chloro-5-(4-trifluoromethyl-benzylsulfanyl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccc(cc3)C(F)(F)F)c(Cl)cc2[nH]1
Show InChI InChI=1S/C19H12ClF3N4O2S/c20-13-5-14-15(26-18(25-14)27-8-11(7-24-27)17(28)29)6-16(13)30-9-10-1-3-12(4-2-10)19(21,22)23/h1-8H,9H2,(H,25,26)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475404
PNG
(1-[5-(4-Benzyloxy-phenyl)-1H-benzoimidazol-2-yl]-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H18N4O3/c29-23(30)19-13-25-28(14-19)24-26-21-11-8-18(12-22(21)27-24)17-6-9-20(10-7-17)31-15-16-4-2-1-3-5-16/h1-14H,15H2,(H,26,27)(H,29,30)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475458
PNG
(1-(6-Chloro-5-phenethylsulfanyl-1H-benzoimidazol-2...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCCc3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C19H15ClN4O2S/c20-14-8-15-16(9-17(14)27-7-6-12-4-2-1-3-5-12)23-19(22-15)24-11-13(10-21-24)18(25)26/h1-5,8-11H,6-7H2,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475559
PNG
(1-[5-(2,4-Bis-trifluoromethyl-benzylsulfanyl)-6-ch...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccc(cc3C(F)(F)F)C(F)(F)F)c(Cl)cc2[nH]1
Show InChI InChI=1S/C20H11ClF6N4O2S/c21-13-4-14-15(30-18(29-14)31-7-10(6-28-31)17(32)33)5-16(13)34-8-9-1-2-11(19(22,23)24)3-12(9)20(25,26)27/h1-7H,8H2,(H,29,30)(H,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475420
PNG
(1-(4-Bromo-5,6-difluoro-1H-benzoimidazol-2-yl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Br)c(F)c(F)cc2[nH]1
Show InChI InChI=1S/C11H5BrF2N4O2/c12-7-8(14)5(13)1-6-9(7)17-11(16-6)18-3-4(2-15-18)10(19)20/h1-3H,(H,16,17)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475431
PNG
(1-(6-Chloro-5-pyrrolidin-1-yl-1H-benzoimidazol-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(N3CCCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C15H14ClN5O2/c16-10-5-11-12(6-13(10)20-3-1-2-4-20)19-15(18-11)21-8-9(7-17-21)14(22)23/h5-8H,1-4H2,(H,18,19)(H,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM50418044
PNG
(CHEMBL1229508 | US10851083, Example 4)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Cl)c(F)cc2[nH]1
Show InChI InChI=1S/C11H6ClFN4O2/c12-6-1-8-9(2-7(6)13)16-11(15-8)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475497
PNG
(1-(6-Bromo-5-fluoro-1H-benzoimidazol-2-yl)-1H- | U...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(F)c(Br)cc2[nH]1
Show InChI InChI=1S/C11H6BrFN4O2/c12-6-1-8-9(2-7(6)13)16-11(15-8)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475557
PNG
(1-[6-Chloro-5-(4-methyl-benzylsulfanyl)-1H- | US10...)
Show SMILES Cc1ccc(CS(=O)(=O)c2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C19H15ClN4O4S/c1-11-2-4-12(5-3-11)10-29(27,28)17-7-16-15(6-14(17)20)22-19(23-16)24-9-13(8-21-24)18(25)26/h2-9H,10H2,1H3,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475475
PNG
(1-[6-Chloro-5-(3,4-dichloro-benzenesulfonyl)-1H- |...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(c(Cl)cc2[nH]1)S(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H9Cl3N4O4S/c18-10-2-1-9(3-11(10)19)29(27,28)15-5-14-13(4-12(15)20)22-17(23-14)24-7-8(6-21-24)16(25)26/h1-7H,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475453
PNG
(1-[6-Chloro-5-(4-methoxy-phenylsulfanyl)-1H- | US1...)
Show SMILES COc1ccc(Sc2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C18H13ClN4O3S/c1-26-11-2-4-12(5-3-11)27-16-7-15-14(6-13(16)19)21-18(22-15)23-9-10(8-20-23)17(24)25/h2-9H,1H3,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475391
PNG
(1-(5-Trifluoromethyl-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C12H7F3N4O2/c13-12(14,15)7-1-2-8-9(3-7)18-11(17-8)19-5-6(4-16-19)10(20)21/h1-5H,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475552
PNG
(1-[6-Chloro-5-(3-chloro-benzylsulfanyl)-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3cccc(Cl)c3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H12Cl2N4O2S/c19-12-3-1-2-10(4-12)9-27-16-6-15-14(5-13(16)20)22-18(23-15)24-8-11(7-21-24)17(25)26/h1-8H,9H2,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475425
PNG
(1-(4-Bromo-6-chloro-1H-benzoimidazol-2-yl)-1H- | U...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Br)cc(Cl)cc2[nH]1
Show InChI InChI=1S/C11H6BrClN4O2/c12-7-1-6(13)2-8-9(7)16-11(15-8)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475433
PNG
(1-(6-Chloro-5-morpholin-4-yl-1H-benzoimidazol-2-yl...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(N3CCOCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C15H14ClN5O3/c16-10-5-11-12(6-13(10)20-1-3-24-4-2-20)19-15(18-11)21-8-9(7-17-21)14(22)23/h5-8H,1-4H2,(H,18,19)(H,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475529
PNG
(1-(5-Benzoylamino-6-chloro-1H-benzoimidazol-2-yl)-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(NC(=O)c3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H12ClN5O3/c19-12-6-14-15(7-13(12)21-16(25)10-4-2-1-3-5-10)23-18(22-14)24-9-11(8-20-24)17(26)27/h1-9H,(H,21,25)(H,22,23)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475435
PNG
(2-(4-Carboxy-pyrazol-1-yl)-1H-benzoimidazole-5- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)C(O)=O
Show InChI InChI=1S/C12H8N4O4/c17-10(18)6-1-2-8-9(3-6)15-12(14-8)16-5-7(4-13-16)11(19)20/h1-5H,(H,14,15)(H,17,18)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475424
PNG
(1-(5,6-Difluoro-1H-benzoimidazol-2-yl)-1H-pyrazole...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(F)c(F)cc2[nH]1
Show InChI InChI=1S/C11H6F2N4O2/c12-6-1-8-9(2-7(6)13)16-11(15-8)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475510
PNG
(1-[5-(Morpholin-4-ylcarbamoyl)-1H-benzoimidazol-2-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)C(=O)NN1CCOCC1
Show InChI InChI=1S/C16H16N6O4/c23-14(20-21-3-5-26-6-4-21)10-1-2-12-13(7-10)19-16(18-12)22-9-11(8-17-22)15(24)25/h1-2,7-9H,3-6H2,(H,18,19)(H,20,23)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475499
PNG
(1-(4,5-Difluoro-1H-benzoimidazol-2-yl)-1H-pyrazole...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(F)c(F)ccc2[nH]1
Show InChI InChI=1S/C11H6F2N4O2/c12-6-1-2-7-9(8(6)13)16-11(15-7)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475525
PNG
(1-(6-Chloro-5-ethanesulfonylamino-1H-benzoimidazol...)
Show SMILES CCS(=O)(=O)Nc1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H12ClN5O4S/c1-2-24(22,23)18-9-4-11-10(3-8(9)14)16-13(17-11)19-6-7(5-15-19)12(20)21/h3-6,18H,2H2,1H3,(H,16,17)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475411
PNG
(1-[5-(4-Hydroxy-phenyl)-1H-benzoimidazol-2-yl]-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1ccc(O)cc1
Show InChI InChI=1S/C17H12N4O3/c22-13-4-1-10(2-5-13)11-3-6-14-15(7-11)20-17(19-14)21-9-12(8-18-21)16(23)24/h1-9,22H,(H,19,20)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475505
PNG
(1-(5-Piperidin-1-yl-6-trifluoromethoxy-1H-benzoimi...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(N3CCCCC3)c(OC(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C17H16F3N5O3/c18-17(19,20)28-14-7-12-11(6-13(14)24-4-2-1-3-5-24)22-16(23-12)25-9-10(8-21-25)15(26)27/h6-9H,1-5H2,(H,22,23)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475519
PNG
(1-(6-Chloro-5-propylamino-1H-benzoimidazol-2-yl)-1...)
Show SMILES CCCNc1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H14ClN5O2/c1-2-3-16-10-5-12-11(4-9(10)15)18-14(19-12)20-7-8(6-17-20)13(21)22/h4-7,16H,2-3H2,1H3,(H,18,19)(H,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475551
PNG
(1-[6-Chloro-5-(4-chloro-benzylsulfanyl)-1H- | US10...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccc(Cl)cc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H12Cl2N4O2S/c19-12-3-1-10(2-4-12)9-27-16-6-15-14(5-13(16)20)22-18(23-15)24-8-11(7-21-24)17(25)26/h1-8H,9H2,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475434
PNG
(1-(6-Chloro-5-methoxy-1H-benzoimidazol-2-yl)-1H- |...)
Show SMILES COc1cc2[nH]c(nc2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9ClN4O3/c1-20-10-3-9-8(2-7(10)13)15-12(16-9)17-5-6(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475399
PNG
(1-(5-Trifluoromethoxy-1H-benzoimidazol-2-yl)-1H- |...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C12H7F3N4O3/c13-12(14,15)22-7-1-2-8-9(3-7)18-11(17-8)19-5-6(4-16-19)10(20)21/h1-5H,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475412
PNG
(1-[5-(3-Hydroxy-phenyl)-1H-benzoimidazol-2-yl]-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(ccc2[nH]1)-c1cccc(O)c1
Show InChI InChI=1S/C17H12N4O3/c22-13-3-1-2-10(6-13)11-4-5-14-15(7-11)20-17(19-14)21-9-12(8-18-21)16(23)24/h1-9,22H,(H,19,20)(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475507
PNG
(1-(6-Ethoxy-5-fluoro-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES CCOc1cc2[nH]c(nc2cc1F)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H11FN4O3/c1-2-21-11-4-10-9(3-8(11)14)16-13(17-10)18-6-7(5-15-18)12(19)20/h3-6H,2H2,1H3,(H,16,17)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475422
PNG
(1-(4,6-Dichloro-1H-benzoimidazol-2-yl)-1H-pyrazole...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Cl)cc(Cl)cc2[nH]1
Show InChI InChI=1S/C11H6Cl2N4O2/c12-6-1-7(13)9-8(2-6)15-11(16-9)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475416
PNG
(1-(5-Chloro-7-trifluoromethyl-1H-benzoimidazol-2-y...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Cl)cc(c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C12H6ClF3N4O2/c13-6-1-7(12(14,15)16)9-8(2-6)18-11(19-9)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475447
PNG
(1-(5-Benzyloxy-6-chloro-1H-benzoimidazol-2-yl)-1H-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(OCc3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H13ClN4O3/c19-13-6-14-15(7-16(13)26-10-11-4-2-1-3-5-11)22-18(21-14)23-9-12(8-20-23)17(24)25/h1-9H,10H2,(H,21,22)(H,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475394
PNG
(1-(5-Bromo-1H-benzoimidazol-2-yl)-1H-pyrazole-4- |...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C11H7BrN4O2/c12-7-1-2-8-9(3-7)15-11(14-8)16-5-6(4-13-16)10(17)18/h1-5H,(H,14,15)(H,17,18)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475429
PNG
(1-(5-Amino-6-chloro-1H-benzoimidazol-2-yl)-1H- | U...)
Show SMILES Nc1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C11H8ClN5O2/c12-6-1-8-9(2-7(6)13)16-11(15-8)17-4-5(3-14-17)10(18)19/h1-4H,13H2,(H,15,16)(H,18,19)
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n/an/a 398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475571
PNG
(1-(6,7-Dichloro-1H-imidazo[4,5-b]quinoxalin-2-yl)-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2nc3cc(Cl)c(Cl)cc3nc2[nH]1
Show InChI InChI=1S/C13H6Cl2N6O2/c14-6-1-8-9(2-7(6)15)18-11-10(17-8)19-13(20-11)21-4-5(3-16-21)12(22)23/h1-4H,(H,22,23)(H,17,18,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475528
PNG
(1-(6-Chloro-5-propionylamino-1H-benzoimidazol-2-yl...)
Show SMILES CCC(=O)Nc1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C14H12ClN5O3/c1-2-12(21)17-9-4-11-10(3-8(9)15)18-14(19-11)20-6-7(5-16-20)13(22)23/h3-6H,2H2,1H3,(H,17,21)(H,18,19)(H,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475397
PNG
(1-(5,6-Dimethoxy-1H-benzoimidazol-2-yl)-1H-pyrazol...)
Show SMILES COc1cc2nc([nH]c2cc1OC)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H12N4O4/c1-20-10-3-8-9(4-11(10)21-2)16-13(15-8)17-6-7(5-14-17)12(18)19/h3-6H,1-2H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475414
PNG
(1-(5-Bromo-6,7-dimethyl-1H-benzoimidazol-2-yl)-1H-...)
Show SMILES Cc1c(Br)cc2nc([nH]c2c1C)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H11BrN4O2/c1-6-7(2)11-10(3-9(6)14)16-13(17-11)18-5-8(4-15-18)12(19)20/h3-5H,1-2H3,(H,16,17)(H,19,20)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475395
PNG
(1-(5-Methoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-...)
Show SMILES COc1ccc2[nH]c(nc2c1)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H10N4O3/c1-19-8-2-3-9-10(4-8)15-12(14-9)16-6-7(5-13-16)11(17)18/h2-6H,1H3,(H,14,15)(H,17,18)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475555
PNG
(1-[6-Chloro-5-(3,4-dichloro-benzylsulfanyl)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(SCc3ccc(Cl)c(Cl)c3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H11Cl3N4O2S/c19-11-2-1-9(3-12(11)20)8-28-16-5-15-14(4-13(16)21)23-18(24-15)25-7-10(6-22-25)17(26)27/h1-7H,8H2,(H,23,24)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475530
PNG
(1-[6-Chloro-5-(2-morpholin-4-yl-acetylamino)-1H- |...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(NC(=O)CN3CCOCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H17ClN6O4/c18-11-5-13-14(22-17(21-13)24-8-10(7-19-24)16(26)27)6-12(11)20-15(25)9-23-1-3-28-4-2-23/h5-8H,1-4,9H2,(H,20,25)(H,21,22)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475532
PNG
(1-{6-Chloro-5[2-(4-methyl-piperazin-1-yl)-acetylam...)
Show SMILES CN1CCN(CC(=O)Nc2cc3nc([nH]c3cc2Cl)-n2cc(cn2)C(O)=O)CC1
Show InChI InChI=1S/C18H20ClN7O3/c1-24-2-4-25(5-3-24)10-16(27)21-13-7-15-14(6-12(13)19)22-18(23-15)26-9-11(8-20-26)17(28)29/h6-9H,2-5,10H2,1H3,(H,21,27)(H,22,23)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475512
PNG
(1-(4-Bromo-6-fluoro-1H-benzoimidazol-2-yl)-1H- | U...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Br)cc(F)cc2[nH]1
Show InChI InChI=1S/C11H6BrFN4O2/c12-7-1-6(13)2-8-9(7)16-11(15-8)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475522
PNG
(1-[6-Chloro-5-(2-morpholin-4-yl-ethylamino)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(NCCN3CCOCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H19ClN6O3/c18-12-7-14-15(8-13(12)19-1-2-23-3-5-27-6-4-23)22-17(21-14)24-10-11(9-20-24)16(25)26/h7-10,19H,1-6H2,(H,21,22)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475527
PNG
(1-(5-Acetylamino-6-chloro-1H-benzoimidazol-2-yl)-1...)
Show SMILES CC(=O)Nc1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H10ClN5O3/c1-6(20)16-9-3-11-10(2-8(9)14)17-13(18-11)19-5-7(4-15-19)12(21)22/h2-5H,1H3,(H,16,20)(H,17,18)(H,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475436
PNG
(1-(5-Bromo-7-fluoro-1H-benzoimidazol-2-yl)-1H- | U...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Br)cc(F)c2[nH]1
Show InChI InChI=1S/C11H6BrFN4O2/c12-6-1-7(13)9-8(2-6)15-11(16-9)17-4-5(3-14-17)10(18)19/h1-4H,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475502
PNG
(1-(1H-Naphtho[2,3-d]imidazol-2-yl)-1H-pyrazole-4- ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc3ccccc3cc2[nH]1
Show InChI InChI=1S/C15H10N4O2/c20-14(21)11-7-16-19(8-11)15-17-12-5-9-3-1-2-4-10(9)6-13(12)18-15/h1-8H,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475430
PNG
(1-(5-Fluoro-1H-benzoimidazol-2-yl)-1H-pyrazole-4- ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C11H7FN4O2/c12-7-1-2-8-9(3-7)15-11(14-8)16-5-6(4-13-16)10(17)18/h1-5H,(H,14,15)(H,17,18)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475511
PNG
(1-(5-Benzyloxymethyl-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(COCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C19H16N4O3/c24-18(25)15-9-20-23(10-15)19-21-16-7-6-14(8-17(16)22-19)12-26-11-13-4-2-1-3-5-13/h1-10H,11-12H2,(H,21,22)(H,24,25)
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n/an/a 501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475413
PNG
(1-(5-Chloro-1H-benzoimidazol-2-yl)-1H-pyrazole-4- ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C11H7ClN4O2/c12-7-1-2-8-9(3-7)15-11(14-8)16-5-6(4-13-16)10(17)18/h1-5H,(H,14,15)(H,17,18)
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n/an/a 501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475531
PNG
(1-[6-Chloro-5-(2-piperidin-1-yl-acetylamino)-1H- |...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(NC(=O)CN3CCCCC3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H19ClN6O3/c19-12-6-14-15(23-18(22-14)25-9-11(8-20-25)17(27)28)7-13(12)21-16(26)10-24-4-2-1-3-5-24/h6-9H,1-5,10H2,(H,21,26)(H,22,23)(H,27,28)
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n/an/a 631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475498
PNG
(1-(4-Fluoro-1H-benzoimidazol-2-yl)-1H-pyrazole-4- ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(F)cccc2[nH]1
Show InChI InChI=1S/C11H7FN4O2/c12-7-2-1-3-8-9(7)15-11(14-8)16-5-6(4-13-16)10(17)18/h1-5H,(H,14,15)(H,17,18)
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n/an/a 631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475520
PNG
(1-(5-Benzylamino-6-chloro-1H-benzoimidazol-2-yl)-1...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(NCc3ccccc3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C18H14ClN5O2/c19-13-6-15-16(7-14(13)20-8-11-4-2-1-3-5-11)23-18(22-15)24-10-12(9-21-24)17(25)26/h1-7,9-10,20H,8H2,(H,22,23)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475518
PNG
(1-(6-Chloro-5-ethylamino-1H-benzoimidazol-2-yl)-1H...)
Show SMILES CCNc1cc2nc([nH]c2cc1Cl)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H12ClN5O2/c1-2-15-9-4-11-10(3-8(9)14)17-13(18-11)19-6-7(5-16-19)12(20)21/h3-6,15H,2H2,1H3,(H,17,18)(H,20,21)
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n/an/a 631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475451
PNG
(1-[6-Chloro-5-(3,4-dichloro-phenylsulfanyl)-1H- | ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cc(Sc3ccc(Cl)c(Cl)c3)c(Cl)cc2[nH]1
Show InChI InChI=1S/C17H9Cl3N4O2S/c18-10-2-1-9(3-11(10)19)27-15-5-14-13(4-12(15)20)22-17(23-14)24-7-8(6-21-24)16(25)26/h1-7H,(H,22,23)(H,25,26)
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n/an/a 661n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM50418041
PNG
(CHEMBL1688402 | US10851083, Example 1)
Show SMILES OC(=O)c1cnn(c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C11H8N4O2/c16-10(17)7-5-12-15(6-7)11-13-8-3-1-2-4-9(8)14-11/h1-6H,(H,13,14)(H,16,17)
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n/an/a 794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475437
PNG
(1-(5-Bromo-7-methyl-1H-benzoimidazol-2-yl)-1H- | U...)
Show SMILES Cc1cc(Br)cc2nc([nH]c12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9BrN4O2/c1-6-2-8(13)3-9-10(6)16-12(15-9)17-5-7(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475393
PNG
(1-(5,6-Dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H12N4O2/c1-7-3-10-11(4-8(7)2)16-13(15-10)17-6-9(5-14-17)12(18)19/h3-6H,1-2H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475415
PNG
(1-(4-Chloro-1H-benzoimidazol-2-yl)-1H-pyrazole-4- ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Cl)cccc2[nH]1
Show InChI InChI=1S/C11H7ClN4O2/c12-7-2-1-3-8-9(7)15-11(14-8)16-5-6(4-13-16)10(17)18/h1-5H,(H,14,15)(H,17,18)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475503
PNG
(1-(3H-Naphtho[1,2-d]imidazol-2-yl)-1H-pyrazole-4- ...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(ccc3ccccc23)[nH]1
Show InChI InChI=1S/C15H10N4O2/c20-14(21)10-7-16-19(8-10)15-17-12-6-5-9-3-1-2-4-11(9)13(12)18-15/h1-8H,(H,17,18)(H,20,21)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475513
PNG
(1-(8H-Imidazo[4',5':3,4]benzo[2,1-d]thiazol-7-yl)-...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2ccc3scnc3c2[nH]1
Show InChI InChI=1S/C12H7N5O2S/c18-11(19)6-3-14-17(4-6)12-15-7-1-2-8-10(9(7)16-12)13-5-20-8/h1-5H,(H,15,16)(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475421
PNG
(1-(6-Chloro-4-methyl-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES Cc1cc(Cl)cc2[nH]c(nc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9ClN4O2/c1-6-2-8(13)3-9-10(6)16-12(15-9)17-5-7(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475572
PNG
(1-(1H-Imidazo[4,5-b]pyrazin-2-yl)-1H-pyrazole-4- |...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2nccnc2[nH]1
Show InChI InChI=1S/C9H6N6O2/c16-8(17)5-3-12-15(4-5)9-13-6-7(14-9)11-2-1-10-6/h1-4H,(H,16,17)(H,10,11,13,14)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475504
PNG
(1-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-1H- | ...)
Show SMILES Cc1c(F)ccc2[nH]c(nc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C12H9FN4O2/c1-6-8(13)2-3-9-10(6)16-12(15-9)17-5-7(4-14-17)11(18)19/h2-5H,1H3,(H,15,16)(H,18,19)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475570
PNG
(1-(1H-Imidazo[4,5-b]quinoxalin-2-yl)-1H-pyrazole-4...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2nc3ccccc3nc2[nH]1
Show InChI InChI=1S/C13H8N6O2/c20-12(21)7-5-14-19(6-7)13-17-10-11(18-13)16-9-4-2-1-3-8(9)15-10/h1-6H,(H,20,21)(H,15,16,17,18)
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n/an/a 3.16E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475573
PNG
(1-(6-Chloro-9H-purin-8-yl)-1H-pyrazole-4-carboxyli...)
Show SMILES OC(=O)c1cnn(c1)-c1nc2c(Cl)ncnc2[nH]1
Show InChI InChI=1S/C9H5ClN6O2/c10-6-5-7(12-3-11-6)15-9(14-5)16-2-4(1-13-16)8(17)18/h1-3H,(H,17,18)(H,11,12,14,15)
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n/an/a 5.01E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475398
PNG
(1-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole...)
Show SMILES Cc1ccc2[nH]c(nc2c1C)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C13H12N4O2/c1-7-3-4-10-11(8(7)2)16-13(15-10)17-6-9(5-14-17)12(18)19/h3-6H,1-2H3,(H,15,16)(H,18,19)
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n/an/a 7.94E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475409
PNG
(1-(5-Bromo-1H-benzoimidazol-2-yl)-3,5-dimethyl-1H-...)
Show SMILES Cc1nn(c(C)c1C(O)=O)-c1nc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C13H11BrN4O2/c1-6-11(12(19)20)7(2)18(17-6)13-15-9-4-3-8(14)5-10(9)16-13/h3-5H,1-2H3,(H,15,16)(H,19,20)
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n/an/a 6.31E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475407
PNG
(1-(5-Bromo-1H-benzoimidazol-2-yl)-3-trifluoromethy...)
Show SMILES OC(=O)c1cn(nc1C(F)(F)F)-c1nc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C12H6BrF3N4O2/c13-5-1-2-7-8(3-5)18-11(17-7)20-4-6(10(21)22)9(19-20)12(14,15)16/h1-4H,(H,17,18)(H,21,22)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475408
PNG
(1-(5,6-dichloro-1H-benzoimidazol-2-yl)-3-trifluoro...)
Show SMILES OC(=O)c1cn(nc1C(F)(F)F)-c1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C12H5Cl2F3N4O2/c13-5-1-7-8(2-6(5)14)19-11(18-7)21-3-4(10(22)23)9(20-21)12(15,16)17/h1-3H,(H,18,19)(H,22,23)
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n/an/a<1.00E+5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
Egl nine homolog 1 (EGLN1)(181-417)


(Homo sapiens (Human))
BDBM475410
PNG
(1-(5,6-Dichloro-1H-benzoimidazol-2-yl)-3,5-dimethy...)
Show SMILES Cc1nn(c(C)c1C(O)=O)-c1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C13H10Cl2N4O2/c1-5-11(12(20)21)6(2)19(18-5)13-16-9-3-7(14)8(15)4-10(9)17-13/h3-4H,1-2H3,(H,16,17)(H,20,21)
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n/an/a<1.00E+5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD2181-417 polypeptide (3 μg) was pre-incubated for 30 minutes with test compound prior to assessing the enzymatic activity of the polypept...


US Patent US10851083 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%