BindingDB logo
myBDB logout

Patent code US10851089

Compile Data Set for Download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475596
PNG
(US10851089, Compound FC-27)
Show SMILES Cc1cc(Sc2ccc(OCc3cccc(CO)c3)cc2)c(o1)C1NC(=O)NC1=O
Show InChI InChI=1S/C22H20N2O5S/c1-13-9-18(20(29-13)19-21(26)24-22(27)23-19)30-17-7-5-16(6-8-17)28-12-15-4-2-3-14(10-15)11-25/h2-10,19,25H,11-12H2,1H3,(H2,23,24,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475587
PNG
(US10851089, Compound FC-17)
Show SMILES NC(=O)c1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C21H17N3O5S/c22-19(25)13-3-1-2-12(10-13)11-29-14-4-6-15(7-5-14)30-16-8-9-28-18(16)17-20(26)24-21(27)23-17/h1-10,17H,11H2,(H2,22,25)(H2,23,24,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475595
PNG
(US10851089, Compound FC-26)
Show SMILES Oc1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C20H16N2O5S/c23-13-3-1-2-12(10-13)11-27-14-4-6-15(7-5-14)28-16-8-9-26-18(16)17-19(24)22-20(25)21-17/h1-10,17,23H,11H2,(H2,21,22,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475517
PNG
(US10851089, Compound FC-30 | US10851089, Compound ...)
Show SMILES Cc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C20H17N3O4S/c1-12-10-13(6-8-21-12)11-27-14-2-4-15(5-3-14)28-16-7-9-26-18(16)17-19(24)23-20(25)22-17/h2-10,17H,11H2,1H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475594
PNG
(US10851089, Compound FC-25)
Show SMILES OCc1ccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)cc1
Show InChI InChI=1S/C21H18N2O5S/c24-11-13-1-3-14(4-2-13)12-28-15-5-7-16(8-6-15)29-17-9-10-27-19(17)18-20(25)23-21(26)22-18/h1-10,18,24H,11-12H2,(H2,22,23,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475592
PNG
(US10851089, Compound FC-23)
Show SMILES OCc1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C21H18N2O5S/c24-11-13-2-1-3-14(10-13)12-28-15-4-6-16(7-5-15)29-17-8-9-27-19(17)18-20(25)23-21(26)22-18/h1-10,18,24H,11-12H2,(H2,22,23,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475582
PNG
(US10851089, Compound FC-12)
Show SMILES CC(C)C1(NC(=O)NC1=O)c1occc1Sc1ccc(OCc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H24N2O4S/c1-15(2)24(22(27)25-23(28)26-24)21-20(11-12-29-21)31-19-9-7-18(8-10-19)30-14-17-6-4-5-16(3)13-17/h4-13,15H,14H2,1-3H3,(H2,25,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475601
PNG
(US10851089, Compound FC-32)
Show SMILES CCC1(NC(=O)NC1=O)c1occc1Sc1ccc(OCc2ccnc(C)c2)cc1
Show InChI InChI=1S/C22H21N3O4S/c1-3-22(20(26)24-21(27)25-22)19-18(9-11-28-19)30-17-6-4-16(5-7-17)29-13-15-8-10-23-14(2)12-15/h4-12H,3,13H2,1-2H3,(H2,24,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475581
PNG
(US10851089, Compound FC-11)
Show SMILES CCCC1(NC(=O)NC1=O)c1occc1Sc1ccc(OCc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H24N2O4S/c1-3-12-24(22(27)25-23(28)26-24)21-20(11-13-29-21)31-19-9-7-18(8-10-19)30-15-17-6-4-5-16(2)14-17/h4-11,13-14H,3,12,15H2,1-2H3,(H2,25,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475580
PNG
(US10851089, Compound FC-10)
Show SMILES CC(C)CC1(NC(=O)NC1=O)c1occc1Sc1ccc(OCc2cccc(C)c2)cc1
Show InChI InChI=1S/C25H26N2O4S/c1-16(2)14-25(23(28)26-24(29)27-25)22-21(11-12-30-22)32-20-9-7-19(8-10-20)31-15-18-6-4-5-17(3)13-18/h4-13,16H,14-15H2,1-3H3,(H2,26,27,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475578
PNG
(US10851089, Compound FC-8)
Show SMILES Cc1cccc(COc2ccc(Sc3ccoc3C3(C)NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C22H20N2O4S/c1-14-4-3-5-15(12-14)13-28-16-6-8-17(9-7-16)29-18-10-11-27-19(18)22(2)20(25)23-21(26)24-22/h3-12H,13H2,1-2H3,(H2,23,24,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475593
PNG
(US10851089, Compound FC-24)
Show SMILES OCc1ccccc1COc1ccc(Sc2ccoc2C2NC(=O)NC2=O)cc1
Show InChI InChI=1S/C21H18N2O5S/c24-11-13-3-1-2-4-14(13)12-28-15-5-7-16(8-6-15)29-17-9-10-27-19(17)18-20(25)23-21(26)22-18/h1-10,18,24H,11-12H2,(H2,22,23,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475579
PNG
(US10851089, Compound FC-9)
Show SMILES CCC1(NC(=O)NC1=O)c1occc1Sc1ccc(OCc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H22N2O4S/c1-3-23(21(26)24-22(27)25-23)20-19(11-12-28-20)30-18-9-7-17(8-10-18)29-14-16-6-4-5-15(2)13-16/h4-13H,3,14H2,1-2H3,(H2,24,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475418
PNG
(US10851089, Compound FC-3)
Show SMILES Cc1cncc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C20H17N3O4S/c1-12-8-13(10-21-9-12)11-27-14-2-4-15(5-3-14)28-16-6-7-26-18(16)17-19(24)23-20(25)22-17/h2-10,17H,11H2,1H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475517
PNG
(US10851089, Compound FC-30 | US10851089, Compound ...)
Show SMILES Cc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C20H17N3O4S/c1-12-10-13(6-8-21-12)11-27-14-2-4-15(5-3-14)28-16-7-9-26-18(16)17-19(24)23-20(25)22-17/h2-10,17H,11H2,1H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475392
PNG
(US10851089, Compound FC-2)
Show SMILES Cc1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)n1
Show InChI InChI=1S/C20H17N3O4S/c1-12-3-2-4-13(21-12)11-27-14-5-7-15(8-6-14)28-16-9-10-26-18(16)17-19(24)23-20(25)22-17/h2-10,17H,11H2,1H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475517
PNG
(US10851089, Compound FC-30 | US10851089, Compound ...)
Show SMILES Cc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C20H17N3O4S/c1-12-10-13(6-8-21-12)11-27-14-2-4-15(5-3-14)28-16-7-9-26-18(16)17-19(24)23-20(25)22-17/h2-10,17H,11H2,1H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475583
PNG
(US10851089, Compound FC-13)
Show SMILES COc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C20H17N3O5S/c1-26-16-10-12(6-8-21-16)11-28-13-2-4-14(5-3-13)29-15-7-9-27-18(15)17-19(24)23-20(25)22-17/h2-10,17H,11H2,1H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475577
PNG
(US10851089, Compound FC-7)
Show SMILES Cc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)cc[n+]1[O-]
Show InChI InChI=1S/C20H17N3O5S/c1-12-10-13(6-8-23(12)26)11-28-14-2-4-15(5-3-14)29-16-7-9-27-18(16)17-19(24)22-20(25)21-17/h2-10,17H,11H2,1H3,(H2,21,22,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475598
PNG
(US10851089, Compound FC-29)
Show SMILES NC(=O)c1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C20H16N4O5S/c21-18(25)14-9-11(5-7-22-14)10-29-12-1-3-13(4-2-12)30-15-6-8-28-17(15)16-19(26)24-20(27)23-16/h1-9,16H,10H2,(H2,21,25)(H2,23,24,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475597
PNG
(US10851089, Compound FC-28)
Show SMILES Cc1cc(Sc2ccc(OCc3cccc(C)c3)cc2)c(o1)C1NC(=O)NC1=O
Show InChI InChI=1S/C22H20N2O4S/c1-13-4-3-5-15(10-13)12-27-16-6-8-17(9-7-16)29-18-11-14(2)28-20(18)19-21(25)24-22(26)23-19/h3-11,19H,12H2,1-2H3,(H2,23,24,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475588
PNG
(US10851089, Compound FC-18)
Show SMILES NC(=O)c1ccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)cc1
Show InChI InChI=1S/C21H17N3O5S/c22-19(25)13-3-1-12(2-4-13)11-29-14-5-7-15(8-6-14)30-16-9-10-28-18(16)17-20(26)24-21(27)23-17/h1-10,17H,11H2,(H2,22,25)(H2,23,24,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475584
PNG
(US10851089, Compound FC-14)
Show SMILES CCOc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C21H19N3O5S/c1-2-27-17-11-13(7-9-22-17)12-29-14-3-5-15(6-4-14)30-16-8-10-28-19(16)18-20(25)24-21(26)23-18/h3-11,18H,2,12H2,1H3,(H2,23,24,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.75E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475590
PNG
(US10851089, Compound FC-21)
Show SMILES CC(C)Oc1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C23H22N2O5S/c1-14(2)30-17-5-3-4-15(12-17)13-29-16-6-8-18(9-7-16)31-19-10-11-28-21(19)20-22(26)25-23(27)24-20/h3-12,14,20H,13H2,1-2H3,(H2,24,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475389
PNG
(US10851089, Compound FC-1)
Show SMILES Cc1ccnc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C20H17N3O4S/c1-12-6-8-21-13(10-12)11-27-14-2-4-15(5-3-14)28-16-7-9-26-18(16)17-19(24)23-20(25)22-17/h2-10,17H,11H2,1H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475576
PNG
(US10851089, Compound FC-6)
Show SMILES Cc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c[n+]([O-])c1
Show InChI InChI=1S/C20H17N3O5S/c1-12-8-13(10-23(26)9-12)11-28-14-2-4-15(5-3-14)29-16-6-7-27-18(16)17-19(24)22-20(25)21-17/h2-10,17H,11H2,1H3,(H2,21,22,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475589
PNG
(US10851089, Compound FC-20)
Show SMILES CCOc1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C22H20N2O5S/c1-2-27-16-5-3-4-14(12-16)13-29-15-6-8-17(9-7-15)30-18-10-11-28-20(18)19-21(25)24-22(26)23-19/h3-12,19H,2,13H2,1H3,(H2,23,24,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475585
PNG
(US10851089, Compound FC-15)
Show SMILES CC(C)COc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C23H23N3O5S/c1-14(2)12-31-19-11-15(7-9-24-19)13-30-16-3-5-17(6-4-16)32-18-8-10-29-21(18)20-22(27)26-23(28)25-20/h3-11,14,20H,12-13H2,1-2H3,(H2,25,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475586
PNG
(US10851089, Compound FC-16)
Show SMILES CC(C)Oc1cc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)ccn1
Show InChI InChI=1S/C22H21N3O5S/c1-13(2)30-18-11-14(7-9-23-18)12-29-15-3-5-16(6-4-15)31-17-8-10-28-20(17)19-21(26)25-22(27)24-19/h3-11,13,19H,12H2,1-2H3,(H2,24,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475575
PNG
(US10851089, Compound FC-5)
Show SMILES Cc1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)[n+]1O
Show InChI InChI=1S/C20H17N3O5S/c1-12-3-2-4-13(23(12)26)11-28-14-5-7-15(8-6-14)29-16-9-10-27-18(16)17-19(24)22-20(25)21-17/h2-10,17H,11H2,1H3,(H2-,21,22,24,25,26)/p+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475602
PNG
(US10851089, Compound FC-33)
Show SMILES CN(Cc1ccnc(C)c1)c1ccc(Sc2ccoc2C2NC(=O)NC2=O)cc1
Show InChI InChI=1S/C21H20N4O3S/c1-13-11-14(7-9-22-13)12-25(2)15-3-5-16(6-4-15)29-17-8-10-28-19(17)18-20(26)24-21(27)23-18/h3-11,18H,12H2,1-2H3,(H2,23,24,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 12


(Homo sapiens (Human))
BDBM475591
PNG
(US10851089, Compound FC-22)
Show SMILES CCCOc1cccc(COc2ccc(Sc3ccoc3C3NC(=O)NC3=O)cc2)c1
Show InChI InChI=1S/C23H22N2O5S/c1-2-11-28-17-5-3-4-15(13-17)14-30-16-6-8-18(9-7-16)31-19-10-12-29-21(19)20-22(26)25-23(27)24-20/h3-10,12-13,20H,2,11,14H2,1H3,(H2,24,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Foresee Pharmaceuticals Co., Ltd.

US Patent


Assay Description
The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...


US Patent US10851089 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%