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Patent code US10851105

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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n/an/a 20n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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n/an/a 115n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
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n/an/a 115n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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n/an/a 115n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475660
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,30,31)(H,32,34)
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n/an/a 115n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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n/an/a 115n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475666
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O4/c1-4-24(36)34-20-10-6-5-9-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)11-7-8-12-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-6,9-10,13-15H,1,7-8,11-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475661
PNG
(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-5-17(28)26(2)16-8-13-12(10-25-16)11-27(21(29)22(13)6-7-22)20-18(23)14(30-3)9-15(31-4)19(20)24/h5,8-10H,1,6-7,11H2,2-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475662
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C27H30F2N4O4/c1-4-22(34)32-18-8-6-5-7-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16)9-10-27)25-23(28)19(36-2)12-20(37-3)24(25)29/h4,11-13,17-18H,1,5-10,14H2,2-3H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475670
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C32H34F2N6O4/c1-5-27(41)37-22-7-6-20(39-12-10-38(2)11-13-39)14-23(22)36-26-15-21-19(17-35-26)18-40(31(42)32(21)8-9-32)30-28(33)24(43-3)16-25(44-4)29(30)34/h5-7,14-17H,1,8-13,18H2,2-4H3,(H,35,36)(H,37,41)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475667
PNG
(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C29H28F2N4O5/c1-4-24(36)34-20-8-6-5-7-19(20)33-23-13-18-17(15-32-23)16-35(28(37)29(18)9-11-40-12-10-29)27-25(30)21(38-2)14-22(39-3)26(27)31/h4-8,13-15H,1,9-12,16H2,2-3H3,(H,32,33)(H,34,36)
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n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475663
PNG
(N-(4-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-20(32)30-16-12-36-11-15(16)29-19-7-14-13(9-28-19)10-31(24(33)25(14)5-6-25)23-21(26)17(34-2)8-18(35-3)22(23)27/h4,7-9,15-16H,1,5-6,10-12H2,2-3H3,(H,28,29)(H,30,32)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM475664
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4NC(=O)C=C)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-5-22(35)32-18-8-6-7-15(2)25(18)33-21-11-17-16(13-31-21)14-34(27(36)28(17)9-10-28)26-23(29)19(37-3)12-20(38-4)24(26)30/h5-8,11-13H,1,9-10,14H2,2-4H3,(H,31,33)(H,32,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475665
PNG
(N-(2-(7-(2,6-difluoro-3,5-dimethoxyphenyl)-5,5-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-6-22(34)32-18-10-8-7-9-17(18)31-21-11-16-15(13-30-21)14-33(26(35)27(16,2)3)25-23(28)19(36-4)12-20(37-5)24(25)29/h6-13H,1,14H2,2-5H3,(H,30,31)(H,32,34)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM475668
PNG
(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOC3)C2=O)c1F
Show InChI InChI=1S/C28H26F2N4O5/c1-4-23(35)33-19-8-6-5-7-18(19)32-22-11-17-16(13-31-22)14-34(27(36)28(17)9-10-39-15-28)26-24(29)20(37-2)12-21(38-3)25(26)30/h4-8,11-13H,1,9-10,14-15H2,2-3H3,(H,31,32)(H,33,35)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475669
PNG
(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C31H31F2N5O5/c1-4-26(39)36-21-6-5-19(37-9-11-43-12-10-37)13-22(21)35-25-14-20-18(16-34-25)17-38(30(40)31(20)7-8-31)29-27(32)23(41-2)15-24(42-3)28(29)33/h4-6,13-16H,1,7-12,17H2,2-3H3,(H,34,35)(H,36,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM475671
PNG
(N-((1 S,2R)-2-(6′-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(OC4CCCC4NC(=O)C=C)nc3C3(CC3)C2=O)c1F
Show InChI InChI=1S/C25H26F2N4O5/c1-4-18(32)29-14-6-5-7-15(14)36-24-28-11-13-12-31(23(33)25(8-9-25)22(13)30-24)21-19(26)16(34-2)10-17(35-3)20(21)27/h4,10-11,14-15H,1,5-9,12H2,2-3H3,(H,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>200n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10851105 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%