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Patent code US10851116

Compile Data Set for Download or QSAR
Found 188 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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US Patent
n/an/an/an/a 25n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475681
PNG
((4aS,8aR)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 924n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475681
PNG
((4aS,8aR)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 1.48E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475686
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(ncc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
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n/an/an/an/a 269n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475687
PNG
((4aR*,8aS*)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 58n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475688
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1nc(ccc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
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n/an/an/an/a 112n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475689
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(cnc1N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 86n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475692
PNG
((4aS*,8aR*)-2- (5-bromo-6- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1nc(ccc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
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n/an/an/an/a 5.78E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 2n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 45n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475697
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 146n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475698
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1
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n/an/an/an/a 4n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 6n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475702
PNG
(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Show SMILES CCC12CNCCC1CCN(C2)c1ncnc2[nH]ccc12
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n/an/an/an/a 25n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475703
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CCC1CCN(C2)c1ncnc2[nH]ccc12)c1nc(cs1)C#N
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n/an/an/an/a 1.11E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475704
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-methylsulfonyl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(C)(=O)=O
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n/an/an/an/a 93n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475704
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-methylsulfonyl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(C)(=O)=O
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n/an/an/an/a 898n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475705
PNG
((3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(N)(=O)=O
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n/an/an/an/a 54n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475705
PNG
((3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(N)(=O)=O
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n/an/an/an/a 473n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
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n/an/an/an/a 1n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475712
PNG
(6-[(3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
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n/an/an/an/a 7.01E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475713
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)S(C)(=O)=O
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n/an/an/an/a 131n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475713
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)S(C)(=O)=O
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n/an/an/an/a 95n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475714
PNG
(US10851116, Example 36 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncccc1CO
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n/an/an/an/a 69n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475716
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-(4-methylsulfonylphenyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cc1)S(C)(=O)=O
PDB

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n/an/an/an/a 7n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475719
PNG
(2-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
PDB

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n/an/an/an/a 2.04E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475720
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
PDB

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n/an/an/an/a 53n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
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n/an/an/an/a 5n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 4n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 1n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 27n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475681
PNG
((4aS,8aR)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 428n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475684
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
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n/an/an/an/a 634n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475687
PNG
((4aR*,8aS*)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 39n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475688
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1nc(ccc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 204n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475689
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(cnc1N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 976n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475694
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C=O
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n/an/an/an/a 43n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 2n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 17n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475697
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 208n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475708
PNG
((3aS*,7aS*)—N-(cyanomethyl)-3a-methyl-5-(7H-p...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)NCC#N
PDB

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n/an/an/an/a 29n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475709
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(2,2,2-trifluoroethylsu...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)CC(F)(F)F
PDB

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n/an/an/an/a 133n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475710
PNG
(3-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)CC#N
PDB

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n/an/an/an/a 16n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475710
PNG
(3-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)CC#N
PDB

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n/an/an/an/a 67n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475710
PNG
(3-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)CC#N
PDB

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n/an/an/an/a 307n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475714
PNG
(US10851116, Example 36 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncccc1CO
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475715
PNG
(US10851116, Example 37 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(Br)cc1CO
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475716
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-(4-methylsulfonylphenyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cc1)S(C)(=O)=O
PDB

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n/an/an/an/a 335n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475717
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-pyrimidin-4-yl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccncn1
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475719
PNG
(2-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475720
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475720
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475722
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(cnc1N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475724
PNG
(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)C1(CCCC1)C#N
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n/an/an/an/a 705n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 6n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475682
PNG
(5- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
PDB

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n/an/an/an/a 4n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475690
PNG
((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1cc(ncc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 4.27E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475693
PNG
(1-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(C)=O
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n/an/an/an/a 69n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475698
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1
PDB

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n/an/an/an/a 269n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475699
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 988n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475703
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CCC1CCN(C2)c1ncnc2[nH]ccc12)c1nc(cs1)C#N
PDB

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n/an/an/an/a 46n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475704
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-methylsulfonyl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(C)(=O)=O
PDB

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n/an/an/an/a 243n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475705
PNG
((3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(N)(=O)=O
PDB

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n/an/an/an/a 80n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475708
PNG
((3aS*,7aS*)—N-(cyanomethyl)-3a-methyl-5-(7H-p...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)NCC#N
PDB

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n/an/an/an/a 91n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475708
PNG
((3aS*,7aS*)—N-(cyanomethyl)-3a-methyl-5-(7H-p...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)NCC#N
PDB

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n/an/an/an/a 364n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475713
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)S(C)(=O)=O
PDB

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n/an/an/an/a 13n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475718
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(ncc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 28n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475721
PNG
(5-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
PDB

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n/an/an/an/a 232n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475722
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(cnc1N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 65n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475723
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1nc(ccc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 1.19E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475681
PNG
((4aS,8aR)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 237n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475685
PNG
(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
PDB

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n/an/an/an/a 740n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475686
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(ncc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 86n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475688
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1nc(ccc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 469n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475688
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1nc(ccc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 3.88E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475690
PNG
((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1cc(ncc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 937n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475691
PNG
((4aR*,8aS*)-8a-methyl-2-methylsulfonyl-7-(7H-pyrro...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(C)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 90n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475691
PNG
((4aR*,8aS*)-8a-methyl-2-methylsulfonyl-7-(7H-pyrro...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(C)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 326n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475693
PNG
(1-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(C)=O
PDB

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n/an/an/an/a 453n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475699
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 2n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 14n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475706
PNG
((3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 827n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475706
PNG
((3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 2.18E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475707
PNG
((3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 35n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475712
PNG
(6-[(3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
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n/an/an/an/a 192n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475714
PNG
(US10851116, Example 36 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncccc1CO
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n/an/an/an/a 1.11E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475715
PNG
(US10851116, Example 37 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(Br)cc1CO
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475721
PNG
(5-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475721
PNG
(5-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475724
PNG
(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)C1(CCCC1)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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n/an/an/an/a 159n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475686
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(ncc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475686
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(ncc1C#N)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475689
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(cnc1N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 85n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475691
PNG
((4aR*,8aS*)-8a-methyl-2-methylsulfonyl-7-(7H-pyrro...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(C)(=O)=O)c1ncnc2[nH]ccc12
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475692
PNG
((4aS*,8aR*)-2- (5-bromo-6- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1nc(ccc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475694
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C=O
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475694
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C=O
PDB

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n/an/an/an/a 41n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475698
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475699
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475703
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CCC1CCN(C2)c1ncnc2[nH]ccc12)c1nc(cs1)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475703
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CCC1CCN(C2)c1ncnc2[nH]ccc12)c1nc(cs1)C#N
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n/an/an/an/a 29n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475707
PNG
((3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 10n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475707
PNG
((3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 123n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475709
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(2,2,2-trifluoroethylsu...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)CC(F)(F)F
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n/an/an/an/a 455n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475709
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(2,2,2-trifluoroethylsu...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)CC(F)(F)F
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n/an/an/an/a 3.18E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
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n/an/an/an/a 5n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475714
PNG
(US10851116, Example 36 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncccc1CO
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475717
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-pyrimidin-4-yl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccncn1
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475718
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(ncc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475722
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(cnc1N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 179n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475722
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(cnc1N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 2.02E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475723
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1nc(ccc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 103n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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n/an/an/an/a 30n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475682
PNG
(5- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
PDB

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n/an/an/an/a 4n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475682
PNG
(5- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
PDB

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n/an/an/an/a 148n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475683
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475683
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475683
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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n/an/an/an/a 453n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475687
PNG
((4aR*,8aS*)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 241n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475694
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C=O
PDB

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n/an/an/an/a 176n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 7n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475697
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 151n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475698
PNG
(2-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1nnc(Br)s1
PDB

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n/an/an/an/a 17n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475699
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 187n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 1n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475702
PNG
(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Show SMILES CCC12CNCCC1CCN(C2)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 157n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475702
PNG
(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Show SMILES CCC12CNCCC1CCN(C2)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 1.98E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475704
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-methylsulfonyl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(C)(=O)=O
PDB

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n/an/an/an/a 154n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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n/an/an/an/a 59n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475715
PNG
(US10851116, Example 37 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(Br)cc1CO
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n/an/an/an/a 48n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475716
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-(4-methylsulfonylphenyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cc1)S(C)(=O)=O
PDB

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n/an/an/an/a 32n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475719
PNG
(2-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
PDB

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n/an/an/an/a 49n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475719
PNG
(2-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
PDB

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n/an/an/an/a 216n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
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n/an/an/an/a 26n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475682
PNG
(5- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
PDB

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n/an/an/an/a 25n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475684
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
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n/an/an/an/a 17n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475684
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
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n/an/an/an/a 64n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475684
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
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n/an/an/an/a 9n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475685
PNG
(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
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n/an/an/an/a 46n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475685
PNG
(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
PDB

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n/an/an/an/a 140n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475690
PNG
((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1cc(ncc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 60n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475693
PNG
(1-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(C)=O
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n/an/an/an/a 1.04E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475702
PNG
(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Show SMILES CCC12CNCCC1CCN(C2)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 16n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475705
PNG
((3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(N)(=O)=O
PDB

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n/an/an/an/a 40n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475706
PNG
((3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 240n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475706
PNG
((3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 2.47E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475708
PNG
((3aS*,7aS*)—N-(cyanomethyl)-3a-methyl-5-(7H-p...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)NCC#N
PDB

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n/an/an/an/a 56n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475712
PNG
(6-[(3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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n/an/an/an/a 1.17E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475716
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-(4-methylsulfonylphenyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cc1)S(C)(=O)=O
PDB

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n/an/an/an/a 71n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475717
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-pyrimidin-4-yl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccncn1
PDB

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n/an/an/an/a 72n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475717
PNG
(4-[(3aR*,7aS*)-3a-methyl-2-pyrimidin-4-yl-1,3,4,6,...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccncn1
PDB

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n/an/an/an/a 775n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475718
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(ncc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 46n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475718
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1cc(ncc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 722n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475720
PNG
(6-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N
PDB

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n/an/an/an/a 10n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475721
PNG
(5-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
PDB

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n/an/an/an/a 22n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
PDB

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n/an/an/an/a 1n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475683
PNG
(6- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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n/an/an/an/a 7n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475685
PNG
(2- [(4aR*,8aS*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
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n/an/an/an/a 5n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475687
PNG
((4aR*,8aS*)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 8n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475689
PNG
(6- [(4aS*,8aR*)- 8a-methyl-7- (7H- pyrrolo[2,3- d]...)
Show SMILES Cc1cc(cnc1N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 380n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475690
PNG
((4aS*,8aR*)-2- (5-bromo-4- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1cc(ncc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
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n/an/an/an/a 203n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475691
PNG
((4aR*,8aS*)-8a-methyl-2-methylsulfonyl-7-(7H-pyrro...)
Show SMILES C[C@@]12CN(CC[C@@H]1CCN(C2)S(C)(=O)=O)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 72n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475692
PNG
((4aS*,8aR*)-2- (5-bromo-6- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1nc(ccc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
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n/an/an/an/a 301n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475692
PNG
((4aS*,8aR*)-2- (5-bromo-6- methyl-2- pyridyl)-8a- ...)
Show SMILES Cc1nc(ccc1Br)N1CC[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
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n/an/an/an/a 990n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475693
PNG
(1-[(4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimi...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(C)=O
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n/an/an/an/a 121n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475697
PNG
((4aS,8aR)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12
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n/an/an/an/a 1.88E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475707
PNG
((3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N
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n/an/an/an/a 118n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475709
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(2,2,2-trifluoroethylsu...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)S(=O)(=O)CC(F)(F)F
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n/an/an/an/a 274n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475710
PNG
(3-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)CC#N
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n/an/an/an/a 162n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475712
PNG
(6-[(3aR,7aR)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@@]12CN(C[C@@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
PDB

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n/an/an/an/a 927n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475713
PNG
(4-[(3aS*,7aS*)-3a-methyl-2-(5-methylsulfonyl-2-pyr...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)S(C)(=O)=O
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n/an/an/an/a 2.44E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475715
PNG
(US10851116, Example 37 | [2-[(3aS*,7aS*)-3a-methyl...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ncc(Br)cc1CO
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n/an/an/an/a 611n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475723
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1nc(ccc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM475723
PNG
(6-[(3aR*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES Cc1nc(ccc1C#N)N1C[C@H]2CCN(C[C@@]2(C)C1)c1ncnc2[nH]ccc12
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM475724
PNG
(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)C1(CCCC1)C#N
PDB

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n/an/an/an/a 97n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM475724
PNG
(1-[(3aS*,7aS*)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrim...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C(=O)C1(CCCC1)C#N
PDB

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n/an/an/an/a 1.51E+3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%