BindingDB logo
myBDB logout

Patent code US10858344

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473979
PNG
(US10858344, Example 89)
Show SMILES CC[C@@](O)(CNS(=O)(=O)C\C=C\CN1CC(=O)NC1=O)c1cccc(OCC(F)F)c1
Show InChI InChI=1S/C19H25F2N3O6S/c1-2-19(27,14-6-5-7-15(10-14)30-12-16(20)21)13-22-31(28,29)9-4-3-8-24-11-17(25)23-18(24)26/h3-7,10,16,22,27H,2,8-9,11-13H2,1H3,(H,23,25,26)/b4-3+/t19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 800n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473978
PNG
(US10858344, Example 88)
Show SMILES CC[C@@](O)(CNS(=O)(=O)CCCCN1CC(=O)NC1=O)c1ccc(F)c(OCC(F)F)c1
Show InChI InChI=1S/C19H26F3N3O6S/c1-2-19(28,13-5-6-14(20)15(9-13)31-11-16(21)22)12-23-32(29,30)8-4-3-7-25-10-17(26)24-18(25)27/h5-6,9,16,23,28H,2-4,7-8,10-12H2,1H3,(H,24,26,27)/t19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 800n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473988
PNG
(US10858344, Example 99)
Show SMILES C[C@@H](NS(=O)(=O)CCCCCN1CC(=O)NC1=O)c1ccc(F)c(Oc2ccccc2)c1
Show InChI InChI=1S/C22H26FN3O5S/c1-16(17-10-11-19(23)20(14-17)31-18-8-4-2-5-9-18)25-32(29,30)13-7-3-6-12-26-15-21(27)24-22(26)28/h2,4-5,8-11,14,16,25H,3,6-7,12-13,15H2,1H3,(H,24,27,28)/t16-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.25E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473973
PNG
(US10858344, Example 81)
Show SMILES CC(C)(NS(=O)(=O)CCCCCN1CC(=O)NC1=O)c1ccc(F)c(OCC2CC2)c1
Show InChI InChI=1S/C21H30FN3O5S/c1-21(2,16-8-9-17(22)18(12-16)30-14-15-6-7-15)24-31(28,29)11-5-3-4-10-25-13-19(26)23-20(25)27/h8-9,12,15,24H,3-7,10-11,13-14H2,1-2H3,(H,23,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473977
PNG
(US10858344, Example 87)
Show SMILES CC[C@@](O)(CNS(=O)(=O)C\C=C\CN1CC(=O)NC1=O)c1ccc(F)c(OCC(F)F)c1
Show InChI InChI=1S/C19H24F3N3O6S/c1-2-19(28,13-5-6-14(20)15(9-13)31-11-16(21)22)12-23-32(29,30)8-4-3-7-25-10-17(26)24-18(25)27/h3-6,9,16,23,28H,2,7-8,10-12H2,1H3,(H,24,26,27)/b4-3+/t19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473975
PNG
(US10858344, Example 83)
Show SMILES CC[C@@](O)(CNS(=O)(=O)CCCCN1CC(=O)NC1=O)c1ccc(F)c(OCC(C)C)c1
Show InChI InChI=1S/C21H32FN3O6S/c1-4-21(28,16-7-8-17(22)18(11-16)31-13-15(2)3)14-23-32(29,30)10-6-5-9-25-12-19(26)24-20(25)27/h7-8,11,15,23,28H,4-6,9-10,12-14H2,1-3H3,(H,24,26,27)/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473980
PNG
(US10858344, Example 90)
Show SMILES CC[C@@](O)(CNS(=O)(=O)CCCCN1CC(=O)NC1=O)c1cccc(OCC(F)F)c1
Show InChI InChI=1S/C19H27F2N3O6S/c1-2-19(27,14-6-5-7-15(10-14)30-12-16(20)21)13-22-31(28,29)9-4-3-8-24-11-17(25)23-18(24)26/h5-7,10,16,22,27H,2-4,8-9,11-13H2,1H3,(H,23,25,26)/t19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473976
PNG
(US10858344, Example 84)
Show SMILES CC[C@@](O)(CNS(=O)(=O)C\C=C\CN1CC(=O)NC1=O)c1ccc(F)c(OCC2CCC2)c1
Show InChI InChI=1S/C22H30FN3O6S/c1-2-22(29,17-8-9-18(23)19(12-17)32-14-16-6-5-7-16)15-24-33(30,31)11-4-3-10-26-13-20(27)25-21(26)28/h3-4,8-9,12,16,24,29H,2,5-7,10-11,13-15H2,1H3,(H,25,27,28)/b4-3+/t22-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473987
PNG
(US10858344, Example 98)
Show SMILES CC[C@@](O)(CNS(=O)(=O)CCCCN1CC(=O)NC1=O)c1ccc(F)c(OCC2CC2)c1
Show InChI InChI=1S/C21H30FN3O6S/c1-2-21(28,16-7-8-17(22)18(11-16)31-13-15-5-6-15)14-23-32(29,30)10-4-3-9-25-12-19(26)24-20(25)27/h7-8,11,15,23,28H,2-6,9-10,12-14H2,1H3,(H,24,26,27)/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473974
PNG
(US10858344, Example 82)
Show SMILES CC[C@@](O)(CNS(=O)(=O)C\C=C\CN1CC(=O)NC1=O)c1ccc(F)c(OCC(C)C)c1
Show InChI InChI=1S/C21H30FN3O6S/c1-4-21(28,16-7-8-17(22)18(11-16)31-13-15(2)3)14-23-32(29,30)10-6-5-9-25-12-19(26)24-20(25)27/h5-8,11,15,23,28H,4,9-10,12-14H2,1-3H3,(H,24,26,27)/b6-5+/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473983
PNG
(US10858344, Example 93)
Show SMILES CC[C@@](O)(CNS(=O)(=O)C\C=C\CN1CC(=O)NC1=O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C21H29N3O6S/c1-2-21(27,17-6-5-7-18(12-17)30-14-16-8-9-16)15-22-31(28,29)11-4-3-10-24-13-19(25)23-20(24)26/h3-7,12,16,22,27H,2,8-11,13-15H2,1H3,(H,23,25,26)/b4-3+/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.75E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473986
PNG
(US10858344, Example 96)
Show SMILES CC[C@@H](NS(=O)(=O)CCCCCN1CC(=O)NC1=O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C21H31N3O5S/c1-2-19(17-7-6-8-18(13-17)29-15-16-9-10-16)23-30(27,28)12-5-3-4-11-24-14-20(25)22-21(24)26/h6-8,13,16,19,23H,2-5,9-12,14-15H2,1H3,(H,22,25,26)/t19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.00E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473982
PNG
(US10858344, Example 92)
Show SMILES CC[C@@](O)(CNS(=O)(=O)CCCCN1CC(=O)NC1=O)c1cccc(OCC(C)C)c1
Show InChI InChI=1S/C21H33N3O6S/c1-4-21(27,17-8-7-9-18(12-17)30-14-16(2)3)15-22-31(28,29)11-6-5-10-24-13-19(25)23-20(24)26/h7-9,12,16,22,27H,4-6,10-11,13-15H2,1-3H3,(H,23,25,26)/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.25E+3n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473989
PNG
(US10858344, Example 100)
Show SMILES C[C@@H](NS(=O)(=O)CCCCCN1CC(=O)NC1=O)c1ccc(F)c(OCC2CCOCC2)c1
Show InChI InChI=1S/C22H32FN3O6S/c1-16(18-5-6-19(23)20(13-18)32-15-17-7-10-31-11-8-17)25-33(29,30)12-4-2-3-9-26-14-21(27)24-22(26)28/h5-6,13,16-17,25H,2-4,7-12,14-15H2,1H3,(H,24,27,28)/t16-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+4n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473990
PNG
(US10858344, Example 101)
Show SMILES CCOC(=O)COc1cc(ccc1F)[C@@H](C)NS(=O)(=O)CCCCCN1CC(=O)NC1=O
Show InChI InChI=1S/C20H28FN3O7S/c1-3-30-19(26)13-31-17-11-15(7-8-16(17)21)14(2)23-32(28,29)10-6-4-5-9-24-12-18(25)22-20(24)27/h7-8,11,14,23H,3-6,9-10,12-13H2,1-2H3,(H,22,25,27)/t14-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+4n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473985
PNG
(US10858344, Example 95)
Show SMILES CC[C@@H](NS(=O)(=O)CC\C=C\CN1CC(=O)NC1=O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C21H29N3O5S/c1-2-19(17-7-6-8-18(13-17)29-15-16-9-10-16)23-30(27,28)12-5-3-4-11-24-14-20(25)22-21(24)26/h3-4,6-8,13,16,19,23H,2,5,9-12,14-15H2,1H3,(H,22,25,26)/b4-3+/t19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>2.50E+4n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473991
PNG
(US10858344, Example 102)
Show SMILES C[C@@H](NS(=O)(=O)CCCCCN1CC(=O)NC1=O)c1ccc(F)c(OCc2nn[nH]n2)c1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>2.50E+4n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473984
PNG
(US10858344, Example 94)
Show SMILES CC[C@@](O)(CNS(=O)(=O)CCCCN1CC(=O)NC1=O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C21H31N3O6S/c1-2-21(27,17-6-5-7-18(12-17)30-14-16-8-9-16)15-22-31(28,29)11-4-3-10-24-13-19(25)23-20(24)26/h5-7,12,16,22,27H,2-4,8-11,13-15H2,1H3,(H,23,25,26)/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+5n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473992
PNG
(US10858344, Example 106)
Show SMILES CCOC(=O)CNc1ccn(CCS(=O)(=O)C[C@H](C)c2ccc(F)c(CCC3CC3)c2)n1
Show InChI InChI=1S/C23H32FN3O4S/c1-3-31-23(28)15-25-22-10-11-27(26-22)12-13-32(29,30)16-17(2)19-8-9-21(24)20(14-19)7-6-18-4-5-18/h8-11,14,17-18H,3-7,12-13,15-16H2,1-2H3,(H,25,26)/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+5n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM473981
PNG
(US10858344, Example 91)
Show SMILES CC[C@@](O)(CNS(=O)(=O)C\C=C\CN1CC(=O)NC1=O)c1cccc(OCC(C)C)c1
Show InChI InChI=1S/C21H31N3O6S/c1-4-21(27,17-8-7-9-18(12-17)30-14-16(2)3)15-22-31(28,29)11-6-5-10-24-13-19(25)23-20(24)26/h5-9,12,16,22,27H,4,10-11,13-15H2,1-3H3,(H,23,25,26)/b6-5+/t21-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+5n/an/an/an/an/an/a



CV6 Therapeutics (NI) Limited

US Patent


Assay Description
The assay employs a DNA polymerase-based approach utilizing an oligonucleotide template with 3 distinct regions: a 3′ primer binding region, a ...


US Patent US10858344 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%