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Found 15 Enz. Inhib. hit(s) with all data for entry = 9557
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474107(Pazopanib metabolite M27 | US10858364, Compound M2...)
Affinity DataKi:  188nMAssay Description:Inhibitory activity on BTK wild type (BTK-WT) and BTK Cys481Ser mutant (BTK-C481S) was measured using the LanthaScreen assay technology from ThermoFi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50:  5nMAssay Description:TBDBTK enzyme (His-BTK (Millipore catalog #14-552)), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474106(US10858364, Formula (II))
Affinity DataIC50:  9.30nMAssay Description:TBDBTK enzyme (His-BTK (Millipore catalog #14-552)), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50:  15nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474107(Pazopanib metabolite M27 | US10858364, Compound M2...)
Affinity DataIC50:  39nMAssay Description:Ramos B cells (ATCC, cat no. CRL-1923) were plated in 24-wells culture plates at 2×106 cells per well in a total volume of 900 μL DMEMF12+10% FB...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474106(US10858364, Formula (II))
Affinity DataIC50:  59nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50:  343nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50:  345nMAssay Description:TEC enzyme (LifeTech # PV3269) and Eu-anti-HIS antibody (Invitrogen # PV5596) are mixed and diluted in kinase buffer (50 mM Hepes pH 7.5+10 mM MgCl2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50:  552nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50:  567nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50:  6.17E+3nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50: >1.00E+4nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474106(US10858364, Formula (II))
Affinity DataIC50: >1.00E+4nMAssay Description:TBITK enzyme (Millipore #14-660M) is diluted to 0.2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50: >1.00E+4nMAssay Description:TBITK enzyme (Millipore #14-660M) is diluted to 0.2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474105(US10858364, formula (I))
Affinity DataIC50: >1.00E+4nMAssay Description:BMX, TXK, EGFR, ERBB2, ERBB4, JAK3, BLK kinase activity was measured using the Z′-LYTE assay at Thermo Fisher. A 10-point dose response (final ...More data for this Ligand-Target Pair
In DepthDetails US Patent