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Patent code US10858373

Compile Data Set for Download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474403
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(phenylsulfony...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O5S/c19-17(20,21)14(18(22,23)24)31-15(27)25-8-6-16(7-9-25)12-26(10-11-30-16)32(28,29)13-4-2-1-3-5-13/h1-5,14H,6-12H2
PDB
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n/an/a 0.259n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474408
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl (3R)-3-[methyl(p...)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22F6N2O5S/c1-26(33(29,30)14-5-3-2-4-6-14)13-11-17(31-12-13)7-9-27(10-8-17)16(28)32-15(18(20,21)22)19(23,24)25/h2-6,13,15H,7-12H2,1H3/t13-/m1/s1
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n/an/a 0.470n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474444
PNG
(US10858373, Example 42)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C20H24F6N2O5S/c1-27(34(30,31)13-14-5-3-2-4-6-14)15-11-18(32-12-15)7-9-28(10-8-18)17(29)33-16(19(21,22)23)20(24,25)26/h2-6,15-16H,7-13H2,1H3
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n/an/a 0.587n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474454
PNG
(US10858373, Example 52)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C(=O)C(C)(C)C
Show InChI InChI=1S/C18H26F6N2O4/c1-15(2,3)13(27)25(4)11-9-16(29-10-11)5-7-26(8-6-16)14(28)30-12(17(19,20)21)18(22,23)24/h11-12H,5-10H2,1-4H3
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n/an/a 0.666n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474429
PNG
(US10858373, Example 27)
Show SMILES CC[C@H]1C[C@H]1S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C17H24F6N2O5S/c1-2-11-9-12(11)31(27,28)25-7-8-29-15(10-25)3-5-24(6-4-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,2-10H2,1H3/t11-,12+/m0/s1
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n/an/a 0.679n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474416
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 2-{[6-(difluorom...)
Show SMILES FC(F)c1ccc(OC2CC3(C2)CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C18H18F8N2O3/c19-13(20)12-2-1-10(9-27-12)30-11-7-16(8-11)3-5-28(6-4-16)15(29)31-14(17(21,22)23)18(24,25)26/h1-2,9,11,13-14H,3-8H2
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n/an/a 0.942n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474404
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-[(4-fluorophen...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C18H19F7N2O5S/c19-12-1-3-13(4-2-12)33(29,30)27-9-10-31-16(11-27)5-7-26(8-6-16)15(28)32-14(17(20,21)22)18(23,24)25/h1-4,14H,5-11H2
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474434
PNG
(US10858373, Example 32)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(C[C@H](CO2)NS(=O)(=O)c2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O5S/c19-17(20,21)14(18(22,23)24)31-15(27)26-8-6-16(7-9-26)10-12(11-30-16)25-32(28,29)13-4-2-1-3-5-13/h1-5,12,14,25H,6-11H2/t12-/m1/s1
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n/an/a 1.08n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474435
PNG
(US10858373, Example 33)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(C[C@@H](CO2)NS(=O)(=O)c2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O5S/c19-17(20,21)14(18(22,23)24)31-15(27)26-8-6-16(7-9-26)10-12(11-30-16)25-32(28,29)13-4-2-1-3-5-13/h1-5,12,14,25H,6-11H2/t12-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474443
PNG
(US10858373, Example 41)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)CC1CCC1
Show InChI InChI=1S/C18H26F6N2O5S/c1-25(32(28,29)11-12-3-2-4-12)13-9-16(30-10-13)5-7-26(8-6-16)15(27)31-14(17(19,20)21)18(22,23)24/h12-14H,2-11H2,1H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474442
PNG
(US10858373, Example 40)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1nccs1
Show InChI InChI=1S/C16H19F6N3O5S2/c1-24(32(27,28)12-23-4-7-31-12)10-8-14(29-9-10)2-5-25(6-3-14)13(26)30-11(15(17,18)19)16(20,21)22/h4,7,10-11H,2-3,5-6,8-9H2,1H3
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n/an/a 1.43n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474451
PNG
(US10858373, Example 49)
Show SMILES FC(F)(F)Oc1cccc(c1)C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H18F9NO4/c20-17(21,22)14(18(23,24)25)32-15(30)29-6-4-16(5-7-29)9-12(10-31-16)11-2-1-3-13(8-11)33-19(26,27)28/h1-3,8,12,14H,4-7,9-10H2
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n/an/a 1.45n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474440
PNG
(US10858373, Example 38)
Show SMILES CC(C)CS(=O)(=O)N(C)C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H26F6N2O5S/c1-11(2)10-31(27,28)24(3)12-8-15(29-9-12)4-6-25(7-5-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,4-10H2,1-3H3
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n/an/a 2.19n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474430
PNG
(US10858373, Example 28)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)CC1CCCCO1)C(F)(F)F
Show InChI InChI=1S/C18H26F6N2O6S/c19-17(20,21)14(18(22,23)24)32-15(27)25-6-4-16(5-7-25)12-26(8-10-31-16)33(28,29)11-13-3-1-2-9-30-13/h13-14H,1-12H2
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n/an/a 2.22n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474433
PNG
(US10858373, Example 31)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)c1cnccn1)C(F)(F)F
Show InChI InChI=1S/C16H18F6N4O5S/c17-15(18,19)12(16(20,21)22)31-13(27)25-5-1-14(2-6-25)10-26(7-8-30-14)32(28,29)11-9-23-3-4-24-11/h3-4,9,12H,1-2,5-8,10H2
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n/an/a 2.26n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474413
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 3-(4-cyanophenyl...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC(CO2)c2ccc(cc2)C#N)CC1)C(F)(F)F
Show InChI InChI=1S/C19H18F6N2O3/c20-18(21,22)15(19(23,24)25)30-16(28)27-7-5-17(6-8-27)9-14(11-29-17)13-3-1-12(10-26)2-4-13/h1-4,14-15H,5-9,11H2
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n/an/a 2.46n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474452
PNG
(US10858373, Example 50)
Show SMILES FC(F)(F)Oc1cccc(c1)C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O
Show InChI InChI=1S/C20H21F3N2O6/c21-20(22,23)30-15-3-1-2-13(10-15)14-11-19(29-12-14)6-8-24(9-7-19)18(28)31-25-16(26)4-5-17(25)27/h1-3,10,14H,4-9,11-12H2
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n/an/a 2.46n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474438
PNG
(US10858373, Example 36)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)CC1CC1
Show InChI InChI=1S/C17H24F6N2O5S/c1-24(31(27,28)10-11-2-3-11)12-8-15(29-9-12)4-6-25(7-5-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,2-10H2,1H3/t12-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474439
PNG
(US10858373, Example 37)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)C1CCC1
Show InChI InChI=1S/C17H24F6N2O5S/c1-24(31(27,28)12-3-2-4-12)11-9-15(29-10-11)5-7-25(8-6-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,2-10H2,1H3
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n/an/a 3.03n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474403
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(phenylsulfony...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O5S/c19-17(20,21)14(18(22,23)24)31-15(27)25-8-6-16(7-9-25)12-26(10-11-30-16)32(28,29)13-4-2-1-3-5-13/h1-5,14H,6-12H2
PDB
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n/an/a 3.09n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474410
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 2-benzoyl-2,8-di...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(C2)C(=O)c2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C19H20F6N2O3/c20-18(21,22)15(19(23,24)25)30-16(29)26-9-6-17(7-10-26)8-11-27(12-17)14(28)13-4-2-1-3-5-13/h1-5,15H,6-12H2
PDB
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n/an/a 3.29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474416
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 2-{[6-(difluorom...)
Show SMILES FC(F)c1ccc(OC2CC3(C2)CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C18H18F8N2O3/c19-13(20)12-2-1-10(9-27-12)30-11-7-16(8-11)3-5-28(6-4-16)15(29)31-14(17(21,22)23)18(24,25)26/h1-2,9,11,13-14H,3-8H2
PDB
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n/an/a 3.63n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474441
PNG
(US10858373, Example 39)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)C1CC1
Show InChI InChI=1S/C16H22F6N2O5S/c1-23(30(26,27)11-2-3-11)10-8-14(28-9-10)4-6-24(7-5-14)13(25)29-12(15(17,18)19)16(20,21)22/h10-12H,2-9H2,1H3
PDB
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n/an/a 4.04n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474408
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl (3R)-3-[methyl(p...)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22F6N2O5S/c1-26(33(29,30)14-5-3-2-4-6-14)13-11-17(31-12-13)7-9-27(10-8-17)16(28)32-15(18(20,21)22)19(23,24)25/h2-6,13,15H,7-12H2,1H3/t13-/m1/s1
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n/an/a 4.39n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474414
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl (3R)-3-(4-fluoro...)
Show SMILES Fc1cnn(c1)[C@H]1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H16F7N3O3/c16-9-6-23-25(7-9)10-5-13(27-8-10)1-3-24(4-2-13)12(26)28-11(14(17,18)19)15(20,21)22/h6-7,10-11H,1-5,8H2/t10-/m1/s1
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n/an/a 4.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474444
PNG
(US10858373, Example 42)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C20H24F6N2O5S/c1-27(34(30,31)13-14-5-3-2-4-6-14)15-11-18(32-12-15)7-9-28(10-8-18)17(29)33-16(19(21,22)23)20(24,25)26/h2-6,15-16H,7-13H2,1H3
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n/an/a 4.93n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474429
PNG
(US10858373, Example 27)
Show SMILES CC[C@H]1C[C@H]1S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C17H24F6N2O5S/c1-2-11-9-12(11)31(27,28)25-7-8-29-15(10-25)3-5-24(6-4-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,2-10H2,1H3/t11-,12+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474417
PNG
(US10858373, Example 15)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1ccccc1)CCO2)C(F)(F)F
Show InChI InChI=1S/C19H22F6N2O3/c20-18(21,22)15(19(23,24)25)30-16(28)27-8-6-17(7-9-27)13-26(10-11-29-17)12-14-4-2-1-3-5-14/h1-5,15H,6-13H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474404
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-[(4-fluorophen...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C18H19F7N2O5S/c19-12-1-3-13(4-2-12)33(29,30)27-9-10-31-16(11-27)5-7-26(8-6-16)15(28)32-14(17(20,21)22)18(23,24)25/h1-4,14H,5-11H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474454
PNG
(US10858373, Example 52)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C(=O)C(C)(C)C
Show InChI InChI=1S/C18H26F6N2O4/c1-15(2,3)13(27)25(4)11-9-16(29-10-11)5-7-26(8-6-16)14(28)30-12(17(19,20)21)18(22,23)24/h11-12H,5-10H2,1-4H3
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n/an/a 8.04n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474451
PNG
(US10858373, Example 49)
Show SMILES FC(F)(F)Oc1cccc(c1)C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H18F9NO4/c20-17(21,22)14(18(23,24)25)32-15(30)29-6-4-16(5-7-29)9-12(10-31-16)11-2-1-3-13(8-11)33-19(26,27)28/h1-3,8,12,14H,4-7,9-10H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474405
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(tetrahydro-2H...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CC1CCCOC1)CCO2)C(F)(F)F
Show InChI InChI=1S/C18H26F6N2O4/c19-17(20,21)14(18(22,23)24)30-15(27)26-5-3-16(4-6-26)12-25(7-9-29-16)10-13-2-1-8-28-11-13/h13-14H,1-12H2
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n/an/a 8.49n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474455
PNG
(US10858373, Example 53)
Show SMILES FC(F)c1ccc(OC2CC3(C2)CCN(CC3)C(=O)ON2C(=O)CCC2=O)cn1
Show InChI InChI=1S/C19H21F2N3O5/c20-17(21)14-2-1-12(11-22-14)28-13-9-19(10-13)5-7-23(8-6-19)18(27)29-24-15(25)3-4-16(24)26/h1-2,11,13,17H,3-10H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474430
PNG
(US10858373, Example 28)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)CC1CCCCO1)C(F)(F)F
Show InChI InChI=1S/C18H26F6N2O6S/c19-17(20,21)14(18(22,23)24)32-15(27)25-6-4-16(5-7-25)12-26(8-10-31-16)33(28,29)11-13-3-1-2-9-30-13/h13-14H,1-12H2
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n/an/a 10.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474418
PNG
(US10858373, Example 16)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1ccc(nc1)C(F)(F)F)CCO2)C(F)(F)F
Show InChI InChI=1S/C19H20F9N3O3/c20-17(21,22)13-2-1-12(9-29-13)10-30-7-8-33-16(11-30)3-5-31(6-4-16)15(32)34-14(18(23,24)25)19(26,27)28/h1-2,9,14H,3-8,10-11H2
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n/an/a 10.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474419
PNG
(US10858373, Example 17)
Show SMILES Fc1ccc(CN2CCOC3(CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)C2)cc1
Show InChI InChI=1S/C19H21F7N2O3/c20-14-3-1-13(2-4-14)11-27-9-10-30-17(12-27)5-7-28(8-6-17)16(29)31-15(18(21,22)23)19(24,25)26/h1-4,15H,5-12H2
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n/an/a 10.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474443
PNG
(US10858373, Example 41)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)CC1CCC1
Show InChI InChI=1S/C18H26F6N2O5S/c1-25(32(28,29)11-12-3-2-4-12)13-9-16(30-10-13)5-7-26(8-6-16)15(27)31-14(17(19,20)21)18(22,23)24/h12-14H,2-11H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474434
PNG
(US10858373, Example 32)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(C[C@H](CO2)NS(=O)(=O)c2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O5S/c19-17(20,21)14(18(22,23)24)31-15(27)26-8-6-16(7-9-26)10-12(11-30-16)25-32(28,29)13-4-2-1-3-5-13/h1-5,12,14,25H,6-11H2/t12-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474420
PNG
(US10858373, Example 18)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1cccnc1C#N)CCO2)C(F)(F)F
Show InChI InChI=1S/C19H20F6N4O3/c20-18(21,22)15(19(23,24)25)32-16(30)29-6-3-17(4-7-29)12-28(8-9-31-17)11-13-2-1-5-27-14(13)10-26/h1-2,5,15H,3-4,6-9,11-12H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474435
PNG
(US10858373, Example 33)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(C[C@@H](CO2)NS(=O)(=O)c2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O5S/c19-17(20,21)14(18(22,23)24)31-15(27)26-8-6-16(7-9-26)10-12(11-30-16)25-32(28,29)13-4-2-1-3-5-13/h1-5,12,14,25H,6-11H2/t12-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474409
PNG
(N-[(3R)-8-{[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl...)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H25N3O7S/c1-21(31(27,28)16-5-3-2-4-6-16)15-13-20(29-14-15)9-11-22(12-10-20)19(26)30-23-17(24)7-8-18(23)25/h2-6,15H,7-14H2,1H3/t15-/m1/s1
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n/an/a 15.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474413
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 3-(4-cyanophenyl...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC(CO2)c2ccc(cc2)C#N)CC1)C(F)(F)F
Show InChI InChI=1S/C19H18F6N2O3/c20-18(21,22)15(19(23,24)25)30-16(28)27-7-5-17(6-8-27)9-14(11-29-17)13-3-1-12(10-26)2-4-13/h1-4,14-15H,5-9,11H2
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n/an/a 17.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474452
PNG
(US10858373, Example 50)
Show SMILES FC(F)(F)Oc1cccc(c1)C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O
Show InChI InChI=1S/C20H21F3N2O6/c21-20(22,23)30-15-3-1-2-13(10-15)14-11-19(29-12-14)6-8-24(9-7-19)18(28)31-25-16(26)4-5-17(25)27/h1-3,10,14H,4-9,11-12H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474406
PNG
(US10858373, Example 4)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)ON2C(=O)CCC2=O)C1
Show InChI InChI=1S/C19H22FN3O7S/c20-14-1-3-15(4-2-14)31(27,28)22-11-12-29-19(13-22)7-9-21(10-8-19)18(26)30-23-16(24)5-6-17(23)25/h1-4H,5-13H2
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n/an/a 20.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474433
PNG
(US10858373, Example 31)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)c1cnccn1)C(F)(F)F
Show InChI InChI=1S/C16H18F6N4O5S/c17-15(18,19)12(16(20,21)22)31-13(27)25-5-1-14(2-6-25)10-26(7-8-30-14)32(28,29)11-9-23-3-4-24-11/h3-4,9,12H,1-2,5-8,10H2
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n/an/a 20.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474440
PNG
(US10858373, Example 38)
Show SMILES CC(C)CS(=O)(=O)N(C)C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H26F6N2O5S/c1-11(2)10-31(27,28)24(3)12-8-15(29-9-12)4-6-25(7-5-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,4-10H2,1-3H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474442
PNG
(US10858373, Example 40)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1nccs1
Show InChI InChI=1S/C16H19F6N3O5S2/c1-24(32(27,28)12-23-4-7-31-12)10-8-14(29-9-10)2-5-25(6-3-14)13(26)30-11(15(17,18)19)16(20,21)22/h4,7,10-11H,2-3,5-6,8-9H2,1H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474449
PNG
(US10858373, Example 47)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C21H27N3O7S/c1-22(32(28,29)15-16-5-3-2-4-6-16)17-13-21(30-14-17)9-11-23(12-10-21)20(27)31-24-18(25)7-8-19(24)26/h2-6,17H,7-15H2,1H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474439
PNG
(US10858373, Example 37)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)C1CCC1
Show InChI InChI=1S/C17H24F6N2O5S/c1-24(31(27,28)12-3-2-4-12)11-9-15(29-10-11)5-7-25(8-6-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,2-10H2,1H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474421
PNG
(US10858373, Example 19)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1nccs1)CCO2)C(F)(F)F
Show InChI InChI=1S/C16H19F6N3O3S/c17-15(18,19)12(16(20,21)22)28-13(26)25-4-1-14(2-5-25)10-24(6-7-27-14)9-11-23-3-8-29-11/h3,8,12H,1-2,4-7,9-10H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474410
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 2-benzoyl-2,8-di...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(C2)C(=O)c2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C19H20F6N2O3/c20-18(21,22)15(19(23,24)25)30-16(29)26-9-6-17(7-10-26)8-11-27(12-17)14(28)13-4-2-1-3-5-13/h1-5,15H,6-12H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474422
PNG
(US10858373, Example 20)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1cnccn1)CCO2)C(F)(F)F
Show InChI InChI=1S/C17H20F6N4O3/c18-16(19,20)13(17(21,22)23)30-14(28)27-5-1-15(2-6-27)11-26(7-8-29-15)10-12-9-24-3-4-25-12/h3-4,9,13H,1-2,5-8,10-11H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474438
PNG
(US10858373, Example 36)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)CC1CC1
Show InChI InChI=1S/C17H24F6N2O5S/c1-24(31(27,28)10-11-2-3-11)12-8-15(29-9-12)4-6-25(7-5-15)14(26)30-13(16(18,19)20)17(21,22)23/h11-13H,2-10H2,1H3/t12-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474423
PNG
(US10858373, Example 21)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1ccccn1)CCO2)C(F)(F)F
Show InChI InChI=1S/C18H21F6N3O3/c19-17(20,21)14(18(22,23)24)30-15(28)27-7-4-16(5-8-27)12-26(9-10-29-16)11-13-3-1-2-6-25-13/h1-3,6,14H,4-5,7-12H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474424
PNG
(US10858373, Example 22)
Show SMILES CC[C@H]1C[C@H]1S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)ON2C(=O)CCC2=O)C1
Show InChI InChI=1S/C18H27N3O7S/c1-2-13-11-14(13)29(25,26)20-9-10-27-18(12-20)5-7-19(8-6-18)17(24)28-21-15(22)3-4-16(21)23/h13-14H,2-12H2,1H3/t13-,14+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474441
PNG
(US10858373, Example 39)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)S(=O)(=O)C1CC1
Show InChI InChI=1S/C16H22F6N2O5S/c1-23(30(26,27)11-2-3-11)10-8-14(28-9-10)4-6-24(7-5-14)13(25)29-12(15(17,18)19)16(20,21)22/h10-12H,2-9H2,1H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474448
PNG
(US10858373, Example 46)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)CC1CCC1
Show InChI InChI=1S/C19H29N3O7S/c1-20(30(26,27)13-14-3-2-4-14)15-11-19(28-12-15)7-9-21(10-8-19)18(25)29-22-16(23)5-6-17(22)24/h14-15H,2-13H2,1H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474436
PNG
(US10858373, Example 34)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC(CO2)NS(=O)(=O)c2ccccc2)CC1
Show InChI InChI=1S/C19H23N3O7S/c23-16-6-7-17(24)22(16)29-18(25)21-10-8-19(9-11-21)12-14(13-28-19)20-30(26,27)15-4-2-1-3-5-15/h1-5,14,20H,6-13H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474417
PNG
(US10858373, Example 15)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1ccccc1)CCO2)C(F)(F)F
Show InChI InChI=1S/C19H22F6N2O3/c20-18(21,22)15(19(23,24)25)30-16(28)27-8-6-17(7-9-27)13-26(10-11-29-17)12-14-4-2-1-3-5-14/h1-5,15H,6-13H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474414
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl (3R)-3-(4-fluoro...)
Show SMILES Fc1cnn(c1)[C@H]1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H16F7N3O3/c16-9-6-23-25(7-9)10-5-13(27-8-10)1-3-24(4-2-13)12(26)28-11(14(17,18)19)15(20,21)22/h6-7,10-11H,1-5,8H2/t10-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474411
PNG
(1-{[(2-Benzoyl-2,8-diazaspiro[4.5]dec-8-yl)carbony...)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CCN(C2)C(=O)c2ccccc2)CC1
Show InChI InChI=1S/C20H23N3O5/c24-16-6-7-17(25)23(16)28-19(27)21-11-8-20(9-12-21)10-13-22(14-20)18(26)15-4-2-1-3-5-15/h1-5H,6-14H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474425
PNG
(US10858373, Example 23)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CC1CCOC1)CCO2)C(F)(F)F
Show InChI InChI=1S/C17H24F6N2O4/c18-16(19,20)13(17(21,22)23)29-14(26)25-4-2-15(3-5-25)11-24(6-8-28-15)9-12-1-7-27-10-12/h12-13H,1-11H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474405
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(tetrahydro-2H...)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CC1CCCOC1)CCO2)C(F)(F)F
Show InChI InChI=1S/C18H26F6N2O4/c19-17(20,21)14(18(22,23)24)30-15(27)26-5-3-16(4-6-26)12-25(7-9-29-16)10-13-2-1-8-28-11-13/h13-14H,1-12H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474419
PNG
(US10858373, Example 17)
Show SMILES Fc1ccc(CN2CCOC3(CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)C2)cc1
Show InChI InChI=1S/C19H21F7N2O3/c20-14-3-1-13(2-4-14)11-27-9-10-30-17(12-27)5-7-28(8-6-17)16(29)31-15(18(21,22)23)19(24,25)26/h1-4,15H,5-12H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474450
PNG
(US10858373, Example 48)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)C1CCC1
Show InChI InChI=1S/C18H27N3O7S/c1-19(29(25,26)14-3-2-4-14)13-11-18(27-12-13)7-9-20(10-8-18)17(24)28-21-15(22)5-6-16(21)23/h13-14H,2-12H2,1H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474455
PNG
(US10858373, Example 53)
Show SMILES FC(F)c1ccc(OC2CC3(C2)CCN(CC3)C(=O)ON2C(=O)CCC2=O)cn1
Show InChI InChI=1S/C19H21F2N3O5/c20-17(21)14-2-1-12(11-22-14)28-13-9-19(10-13)5-7-23(8-6-19)18(27)29-24-15(25)3-4-16(24)26/h1-2,11,13,17H,3-10H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474447
PNG
(US10858373, Example 45)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)c1nccs1
Show InChI InChI=1S/C17H22N4O7S2/c1-19(30(25,26)15-18-6-9-29-15)12-10-17(27-11-12)4-7-20(8-5-17)16(24)28-21-13(22)2-3-14(21)23/h6,9,12H,2-5,7-8,10-11H2,1H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474431
PNG
(US10858373, Example 29)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)CC1CCCCO1
Show InChI InChI=1S/C19H29N3O8S/c23-16-4-5-17(24)22(16)30-18(25)20-8-6-19(7-9-20)14-21(10-12-29-19)31(26,27)13-15-3-1-2-11-28-15/h15H,1-14H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474418
PNG
(US10858373, Example 16)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1ccc(nc1)C(F)(F)F)CCO2)C(F)(F)F
Show InChI InChI=1S/C19H20F9N3O3/c20-17(21,22)13-2-1-12(9-29-13)10-30-7-8-33-16(11-30)3-5-31(6-4-16)15(32)34-14(18(23,24)25)19(26,27)28/h1-2,9,14H,3-8,10-11H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474446
PNG
(US10858373, Example 44)
Show SMILES CC(C)CS(=O)(=O)N(C)C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O
Show InChI InChI=1S/C18H29N3O7S/c1-13(2)12-29(25,26)19(3)14-10-18(27-11-14)6-8-20(9-7-18)17(24)28-21-15(22)4-5-16(21)23/h13-14H,4-12H2,1-3H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474412
PNG
(4-(8-{[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl}-1-o...)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC(CO2)c2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C20H21N3O5/c21-12-14-1-3-15(4-2-14)16-11-20(27-13-16)7-9-22(10-8-20)19(26)28-23-17(24)5-6-18(23)25/h1-4,16H,5-11,13H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474426
PNG
(US10858373, Example 24)
Show SMILES CC(C)CN1CCOC2(CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C16H24F6N2O3/c1-11(2)9-23-7-8-26-14(10-23)3-5-24(6-4-14)13(25)27-12(15(17,18)19)16(20,21)22/h11-12H,3-10H2,1-2H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474420
PNG
(US10858373, Example 18)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1cccnc1C#N)CCO2)C(F)(F)F
Show InChI InChI=1S/C19H20F6N4O3/c20-18(21,22)15(19(23,24)25)32-16(30)29-6-3-17(4-7-29)12-28(8-9-31-17)11-13-2-1-5-27-14(13)10-26/h1-2,5,15H,3-4,6-9,11-12H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474437
PNG
(US10858373, Example 35)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)CC1CC1
Show InChI InChI=1S/C18H27N3O7S/c1-19(29(25,26)12-13-2-3-13)14-10-18(27-11-14)6-8-20(9-7-18)17(24)28-21-15(22)4-5-16(21)23/h13-14H,2-12H2,1H3/t14-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474415
PNG
(1-({[(3R)-3-(4-Fluoro-1H-pyrazol-1-yl)-1-oxa-8-aza...)
Show SMILES Fc1cnn(c1)[C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O
Show InChI InChI=1S/C16H19FN4O5/c17-11-8-18-20(9-11)12-7-16(25-10-12)3-5-19(6-4-16)15(24)26-21-13(22)1-2-14(21)23/h8-9,12H,1-7,10H2/t12-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474432
PNG
(US10858373, Example 30)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)c1cnccn1
Show InChI InChI=1S/C17H21N5O7S/c23-14-1-2-15(24)22(14)29-16(25)20-7-3-17(4-8-20)12-21(9-10-28-17)30(26,27)13-11-18-5-6-19-13/h5-6,11H,1-4,7-10,12H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474407
PNG
(1-{[(4-Benzyl-1-oxa-4,9-diazaspiro[5.5]undec-9-yl)...)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(Cc1ccccc1)CCO2
Show InChI InChI=1S/C20H25N3O5/c24-17-6-7-18(25)23(17)28-19(26)22-10-8-20(9-11-22)15-21(12-13-27-20)14-16-4-2-1-3-5-16/h1-5H,6-15H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474427
PNG
(US10858373, Example 25)
Show SMILES Fc1ccc(CN2CCOC3(CCN(CC3)C(=O)ON3C(=O)CCC3=O)C2)cc1
Show InChI InChI=1S/C20H24FN3O5/c21-16-3-1-15(2-4-16)13-22-11-12-28-20(14-22)7-9-23(10-8-20)19(27)29-24-17(25)5-6-18(24)26/h1-4H,5-14H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474449
PNG
(US10858373, Example 47)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C21H27N3O7S/c1-22(32(28,29)15-16-5-3-2-4-6-16)17-13-21(30-14-17)9-11-23(12-10-21)20(27)31-24-18(25)7-8-19(24)26/h2-6,17H,7-15H2,1H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474406
PNG
(US10858373, Example 4)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)ON2C(=O)CCC2=O)C1
Show InChI InChI=1S/C19H22FN3O7S/c20-14-1-3-15(4-2-14)31(27,28)22-11-12-29-19(13-22)7-9-21(10-8-19)18(26)30-23-16(24)5-6-17(23)25/h1-4H,5-13H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474409
PNG
(N-[(3R)-8-{[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl...)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H25N3O7S/c1-21(31(27,28)16-5-3-2-4-6-16)15-13-20(29-14-15)9-11-22(12-10-20)19(26)30-23-17(24)7-8-18(23)25/h2-6,15H,7-14H2,1H3/t15-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474421
PNG
(US10858373, Example 19)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1nccs1)CCO2)C(F)(F)F
Show InChI InChI=1S/C16H19F6N3O3S/c17-15(18,19)12(16(20,21)22)28-13(26)25-4-1-14(2-5-25)10-24(6-7-27-14)9-11-23-3-8-29-11/h3,8,12H,1-2,4-7,9-10H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474445
PNG
(US10858373, Example 43)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)C1CC1
Show InChI InChI=1S/C17H25N3O7S/c1-18(28(24,25)13-2-3-13)12-10-17(26-11-12)6-8-19(9-7-17)16(23)27-20-14(21)4-5-15(20)22/h12-13H,2-11H2,1H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474453
PNG
(US10858373, Example 51)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)C(=O)C(C)(C)C
Show InChI InChI=1S/C19H29N3O6/c1-18(2,3)16(25)20(4)13-11-19(27-12-13)7-9-21(10-8-19)17(26)28-22-14(23)5-6-15(22)24/h13H,5-12H2,1-4H3
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474422
PNG
(US10858373, Example 20)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1cnccn1)CCO2)C(F)(F)F
Show InChI InChI=1S/C17H20F6N4O3/c18-16(19,20)13(17(21,22)23)30-14(28)27-5-1-15(2-6-27)11-26(7-8-29-15)10-12-9-24-3-4-25-12/h3-4,9,13H,1-2,5-8,10-11H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474431
PNG
(US10858373, Example 29)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)CC1CCCCO1
Show InChI InChI=1S/C19H29N3O8S/c23-16-4-5-17(24)22(16)30-18(25)20-8-6-19(7-9-20)14-21(10-12-29-19)31(26,27)13-15-3-1-2-11-28-15/h15H,1-14H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474423
PNG
(US10858373, Example 21)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(Cc1ccccn1)CCO2)C(F)(F)F
Show InChI InChI=1S/C18H21F6N3O3/c19-17(20,21)14(18(22,23)24)30-15(28)27-7-4-16(5-8-27)12-26(9-10-29-16)11-13-3-1-2-6-25-13/h1-3,6,14H,4-5,7-12H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474436
PNG
(US10858373, Example 34)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC(CO2)NS(=O)(=O)c2ccccc2)CC1
Show InChI InChI=1S/C19H23N3O7S/c23-16-6-7-17(24)22(16)29-18(25)21-10-8-19(9-11-21)12-14(13-28-19)20-30(26,27)15-4-2-1-3-5-15/h1-5,14,20H,6-13H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474425
PNG
(US10858373, Example 23)
Show SMILES FC(F)(F)C(OC(=O)N1CCC2(CC1)CN(CC1CCOC1)CCO2)C(F)(F)F
Show InChI InChI=1S/C17H24F6N2O4/c18-16(19,20)13(17(21,22)23)29-14(26)25-4-2-15(3-5-25)11-24(6-8-28-15)9-12-1-7-27-10-12/h12-13H,1-11H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474426
PNG
(US10858373, Example 24)
Show SMILES CC(C)CN1CCOC2(CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C16H24F6N2O3/c1-11(2)9-23-7-8-26-14(10-23)3-5-24(6-4-14)13(25)27-12(15(17,18)19)16(20,21)22/h11-12H,3-10H2,1-2H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474424
PNG
(US10858373, Example 22)
Show SMILES CC[C@H]1C[C@H]1S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)ON2C(=O)CCC2=O)C1
Show InChI InChI=1S/C18H27N3O7S/c1-2-13-11-14(13)29(25,26)20-9-10-27-18(12-20)5-7-19(8-6-18)17(24)28-21-15(22)3-4-16(21)23/h13-14H,2-12H2,1H3/t13-,14+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474448
PNG
(US10858373, Example 46)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)CC1CCC1
Show InChI InChI=1S/C19H29N3O7S/c1-20(30(26,27)13-14-3-2-4-14)15-11-19(28-12-15)7-9-21(10-8-19)18(25)29-22-16(23)5-6-17(22)24/h14-15H,2-13H2,1H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474428
PNG
(US10858373, Example 26)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(Cc1cnccn1)CCO2
Show InChI InChI=1S/C18H23N5O5/c24-15-1-2-16(25)23(15)28-17(26)22-7-3-18(4-8-22)13-21(9-10-27-18)12-14-11-19-5-6-20-14/h5-6,11H,1-4,7-10,12-13H2
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Pfizer Inc.

US Patent


Assay Description
T = 30 minutes.


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474412
PNG
(4-(8-{[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl}-1-o...)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC(CO2)c2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C20H21N3O5/c21-12-14-1-3-15(4-2-14)16-11-20(27-13-16)7-9-22(10-8-20)19(26)28-23-17(24)5-6-18(23)25/h1-4,16H,5-11,13H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474447
PNG
(US10858373, Example 45)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)c1nccs1
Show InChI InChI=1S/C17H22N4O7S2/c1-19(30(25,26)15-18-6-9-29-15)12-10-17(27-11-12)4-7-20(8-5-17)16(24)28-21-13(22)2-3-14(21)23/h6,9,12H,2-5,7-8,10-11H2,1H3
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n/an/a 655n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474453
PNG
(US10858373, Example 51)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)C(=O)C(C)(C)C
Show InChI InChI=1S/C19H29N3O6/c1-18(2,3)16(25)20(4)13-11-19(27-12-13)7-9-21(10-8-19)17(26)28-22-14(23)5-6-15(22)24/h13H,5-12H2,1-4H3
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474411
PNG
(1-{[(2-Benzoyl-2,8-diazaspiro[4.5]dec-8-yl)carbony...)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CCN(C2)C(=O)c2ccccc2)CC1
Show InChI InChI=1S/C20H23N3O5/c24-16-6-7-17(25)23(16)28-19(27)21-11-8-20(9-12-21)10-13-22(14-20)18(26)15-4-2-1-3-5-15/h1-5H,6-14H2
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Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474446
PNG
(US10858373, Example 44)
Show SMILES CC(C)CS(=O)(=O)N(C)C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O
Show InChI InChI=1S/C18H29N3O7S/c1-13(2)12-29(25,26)19(3)14-10-18(27-11-14)6-8-20(9-7-18)17(24)28-21-15(22)4-5-16(21)23/h13-14H,4-12H2,1-3H3
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n/an/a 794n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474450
PNG
(US10858373, Example 48)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)C1CCC1
Show InChI InChI=1S/C18H27N3O7S/c1-19(29(25,26)14-3-2-4-14)13-11-18(27-12-13)7-9-20(10-8-18)17(24)28-21-15(22)5-6-16(21)23/h13-14H,2-12H2,1H3
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n/an/a 797n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474427
PNG
(US10858373, Example 25)
Show SMILES Fc1ccc(CN2CCOC3(CCN(CC3)C(=O)ON3C(=O)CCC3=O)C2)cc1
Show InChI InChI=1S/C20H24FN3O5/c21-16-3-1-15(2-4-16)13-22-11-12-28-20(14-22)7-9-23(10-8-20)19(27)29-24-17(25)5-6-18(24)26/h1-4H,5-14H2
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n/an/a 1.32E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474437
PNG
(US10858373, Example 35)
Show SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)CC1CC1
Show InChI InChI=1S/C18H27N3O7S/c1-19(29(25,26)12-13-2-3-13)14-10-18(27-11-14)6-8-20(9-7-18)17(24)28-21-15(22)4-5-16(21)23/h13-14H,2-12H2,1H3/t14-/m1/s1
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n/an/a 1.38E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474407
PNG
(1-{[(4-Benzyl-1-oxa-4,9-diazaspiro[5.5]undec-9-yl)...)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(Cc1ccccc1)CCO2
Show InChI InChI=1S/C20H25N3O5/c24-17-6-7-18(25)23(17)28-19(26)22-10-8-20(9-11-22)15-21(12-13-27-20)14-16-4-2-1-3-5-16/h1-5H,6-15H2
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n/an/a 1.48E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474432
PNG
(US10858373, Example 30)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(CCO2)S(=O)(=O)c1cnccn1
Show InChI InChI=1S/C17H21N5O7S/c23-14-1-2-15(24)22(14)29-16(25)20-7-3-17(4-8-20)12-21(9-10-28-17)30(26,27)13-11-18-5-6-19-13/h5-6,11H,1-4,7-10,12H2
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n/an/a 1.54E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474415
PNG
(1-({[(3R)-3-(4-Fluoro-1H-pyrazol-1-yl)-1-oxa-8-aza...)
Show SMILES Fc1cnn(c1)[C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O
Show InChI InChI=1S/C16H19FN4O5/c17-11-8-18-20(9-11)12-7-16(25-10-12)3-5-19(6-4-16)15(24)26-21-13(22)1-2-14(21)23/h8-9,12H,1-7,10H2/t12-/m1/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474445
PNG
(US10858373, Example 43)
Show SMILES CN(C1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)C1CC1
Show InChI InChI=1S/C17H25N3O7S/c1-18(28(24,25)13-2-3-13)12-10-17(26-11-12)6-8-19(9-7-17)16(23)27-20-14(21)4-5-15(20)22/h12-13H,2-11H2,1H3
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n/an/a 2.72E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM474428
PNG
(US10858373, Example 26)
Show SMILES O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(Cc1cnccn1)CCO2
Show InChI InChI=1S/C18H23N5O5/c24-15-1-2-16(25)23(15)28-17(26)22-7-3-18(4-8-22)13-21(9-10-27-18)12-14-11-19-5-6-20-14/h5-6,11H,1-4,7-10,12-13H2
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n/an/a>3.00E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...


US Patent US10858373 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%