BindingDB logo
myBDB logout

Patent code US10865186

Compile Data Set for Download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50027366
PNG
(KETAZOCINE | Ketazocine | US10081602, Example Keta...)
Show SMILES C[C@H]1[C@@H]2N(CC3CC3)CC[C@@]1(C)c1cc(O)ccc1C2=O
Show InChI InChI=1S/C18H23NO2/c1-11-16-17(21)14-6-5-13(20)9-15(14)18(11,2)7-8-19(16)10-12-3-4-12/h5-6,9,11-12,16,20H,3-4,7-8,10H2,1-2H3/t11-,16-,18+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
1.30n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM168148
PNG
(US10081602, Example 20 | US10865186, Compound 20 |...)
Show SMILES C[C@H]1C2N(CC3CC3)CC[C@@]1(C)c1cc(Nc3ccc(NCCOCCOCCOCCOCCOC(F)(F)F)cc3)ccc1C2=O
Show InChI InChI=1S/C35H48F3N3O6/c1-25-32-33(42)30-10-9-29(23-31(30)34(25,2)11-13-41(32)24-26-3-4-26)40-28-7-5-27(6-8-28)39-12-14-43-15-16-44-17-18-45-19-20-46-21-22-47-35(36,37)38/h5-10,23,25-26,32,39-40H,3-4,11-22,24H2,1-2H3/t25-,32?,34+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.86n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475934
PNG
(Preparation of (2S,6R,11R)-8-((4-(2,5,8,11,14-pent...)
Show SMILES COCCOCCCCCOCCOCCNc1ccc(Nc2ccc3C(=O)C4[C@H](C)[C@@](C)(CCN4CC4CC4)c3c2)cc1
Show InChI InChI=1S/C36H53N3O5/c1-27-34-35(40)32-14-13-31(25-33(32)36(27,2)15-17-39(34)26-28-7-8-28)38-30-11-9-29(10-12-30)37-16-20-44-24-23-43-19-6-4-5-18-42-22-21-41-3/h9-14,25,27-28,34,37-38H,4-8,15-24,26H2,1-3H3/t27-,34?,36+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
5n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM168148
PNG
(US10081602, Example 20 | US10865186, Compound 20 |...)
Show SMILES C[C@H]1C2N(CC3CC3)CC[C@@]1(C)c1cc(Nc3ccc(NCCOCCOCCOCCOCCOC(F)(F)F)cc3)ccc1C2=O
Show InChI InChI=1S/C35H48F3N3O6/c1-25-32-33(42)30-10-9-29(23-31(30)34(25,2)11-13-41(32)24-26-3-4-26)40-28-7-5-27(6-8-28)39-12-14-43-15-16-44-17-18-45-19-20-46-21-22-47-35(36,37)38/h5-10,23,25-26,32,39-40H,3-4,11-22,24H2,1-2H3/t25-,32?,34+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
44.3n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent




US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM475934
PNG
(Preparation of (2S,6R,11R)-8-((4-(2,5,8,11,14-pent...)
Show SMILES COCCOCCCCCOCCOCCNc1ccc(Nc2ccc3C(=O)C4[C@H](C)[C@@](C)(CCN4CC4CC4)c3c2)cc1
Show InChI InChI=1S/C36H53N3O5/c1-27-34-35(40)32-14-13-31(25-33(32)36(27,2)15-17-39(34)26-28-7-8-28)38-30-11-9-29(10-12-30)37-16-20-44-24-23-43-19-6-4-5-18-42-22-21-41-3/h9-14,25,27-28,34,37-38H,4-8,15-24,26H2,1-3H3/t27-,34?,36+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
58.5n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent




US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM168144
PNG
(US10865186, Compound 4 | US9688638, 4 | US9688638,...)
Show SMILES COCCOCCOCCOc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C25H37NO5/c1-18-23-24(27)21-7-6-20(31-15-14-30-13-12-29-11-10-28-3)16-22(21)25(18,2)8-9-26(23)17-19-4-5-19/h6-7,16,18-19,23H,4-5,8-15,17H2,1-3H3/t18-,23-,25-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
203n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM168150
PNG
(US10081602, Example 24 | US10865186, Compound 24 |...)
Show SMILES C[C@H]1[C@@H]2N(CC3CC3)CC[C@@]1(C)c1cc(NC(CO)CO)ccc1C2=O
Show InChI InChI=1S/C21H30N2O3/c1-13-19-20(26)17-6-5-15(22-16(11-24)12-25)9-18(17)21(13,2)7-8-23(19)10-14-3-4-14/h5-6,9,13-14,16,19,22,24-25H,3-4,7-8,10-12H2,1-2H3/t13-,19-,21+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
494n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475929
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-6...)
Show SMILES COCCOCCOCCOCCOCCNc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C29H46N2O6/c1-22-27-28(32)25-7-6-24(20-26(25)29(22,2)8-10-31(27)21-23-4-5-23)30-9-11-34-14-15-36-18-19-37-17-16-35-13-12-33-3/h6-7,20,22-23,27,30H,4-5,8-19,21H2,1-3H3/t22-,27-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
549n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475928
PNG
(Preparation of (2S,6R,11R)-3-(cyclopropylmethyl)-8...)
Show SMILES COCCOCCOCCN1CCN(CC1)c1ccc2C(=O)[C@@H]3[C@H](C)[C@@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C29H45N3O4/c1-22-27-28(33)25-7-6-24(20-26(25)29(22,2)8-9-32(27)21-23-4-5-23)31-12-10-30(11-13-31)14-15-35-18-19-36-17-16-34-3/h6-7,20,22-23,27H,4-5,8-19,21H2,1-3H3/t22-,27-,29+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
619n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475930
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-8...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCNc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C33H54N2O8/c1-26-31-32(36)29-7-6-28(24-30(29)33(26,2)8-10-35(31)25-27-4-5-27)34-9-11-38-14-15-40-18-19-42-22-23-43-21-20-41-17-16-39-13-12-37-3/h6-7,24,26-27,31,34H,4-5,8-23,25H2,1-3H3/t26-,31-,33-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
769n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475939
PNG
(Preparation of (1R,2S,6R,11R)-1-(2,5,8,11,14-penta...)
Show SMILES COCCOCCOCCOCCO[C@H]1[C@@H]2[C@H](C)[C@@](C)(CCN2CC2CC2)c2cc(O)ccc12
Show InChI InChI=1S/C27H43NO6/c1-20-25-26(34-17-16-33-15-14-32-13-12-31-11-10-30-3)23-7-6-22(29)18-24(23)27(20,2)8-9-28(25)19-21-4-5-21/h6-7,18,20-21,25-26,29H,4-5,8-17,19H2,1-3H3/t20-,25-,26+,27+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
955n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM168149
PNG
(US10081602, Example 23 | US10865186, Compound 23 |...)
Show SMILES C[C@H]1[C@@H]2N(CC3CC3)CC[C@@]1(C)c1cc(NC(C)(C)CO)ccc1C2=O
Show InChI InChI=1S/C22H32N2O2/c1-14-19-20(26)17-8-7-16(23-21(2,3)13-25)11-18(17)22(14,4)9-10-24(19)12-15-5-6-15/h7-8,11,14-15,19,23,25H,5-6,9-10,12-13H2,1-4H3/t14-,19-,22+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.06E+3n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475933
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-8...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C33H53NO9/c1-26-31-32(35)29-7-6-28(24-30(29)33(26,2)8-9-34(31)25-27-4-5-27)43-23-22-42-21-20-41-19-18-40-17-16-39-15-14-38-13-12-37-11-10-36-3/h6-7,24,26-27,31H,4-5,8-23,25H2,1-3H3/t26-,31-,33-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.40E+3n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM168150
PNG
(US10081602, Example 24 | US10865186, Compound 24 |...)
Show SMILES C[C@H]1[C@@H]2N(CC3CC3)CC[C@@]1(C)c1cc(NC(CO)CO)ccc1C2=O
Show InChI InChI=1S/C21H30N2O3/c1-13-19-20(26)17-6-5-15(22-16(11-24)12-25)9-18(17)21(13,2)7-8-23(19)10-14-3-4-14/h5-6,9,13-14,16,19,22,24-25H,3-4,7-8,10-12H2,1-2H3/t13-,19-,21+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.81E+3n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent




US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475932
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-6...)
Show SMILES COCCOCCOCCOCCOCCOc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C29H45NO7/c1-22-27-28(31)25-7-6-24(20-26(25)29(22,2)8-9-30(27)21-23-4-5-23)37-19-18-36-17-16-35-15-14-34-13-12-33-11-10-32-3/h6-7,20,22-23,27H,4-5,8-19,21H2,1-3H3/t22-,27-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.96E+3n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM475939
PNG
(Preparation of (1R,2S,6R,11R)-1-(2,5,8,11,14-penta...)
Show SMILES COCCOCCOCCOCCO[C@H]1[C@@H]2[C@H](C)[C@@](C)(CCN2CC2CC2)c2cc(O)ccc12
Show InChI InChI=1S/C27H43NO6/c1-20-25-26(34-17-16-33-15-14-32-13-12-31-11-10-30-3)23-7-6-22(29)18-24(23)27(20,2)8-9-28(25)19-21-4-5-21/h6-7,18,20-21,25-26,29H,4-5,8-17,19H2,1-3H3/t20-,25-,26+,27+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
3.92E+3n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent




US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM168149
PNG
(US10081602, Example 23 | US10865186, Compound 23 |...)
Show SMILES C[C@H]1[C@@H]2N(CC3CC3)CC[C@@]1(C)c1cc(NC(C)(C)CO)ccc1C2=O
Show InChI InChI=1S/C22H32N2O2/c1-14-19-20(26)17-8-7-16(23-21(2,3)13-25)11-18(17)22(14,4)9-10-24(19)12-15-5-6-15/h7-8,11,14-15,19,23,25H,5-6,9-10,12-13H2,1-4H3/t14-,19-,22+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
7.96E+3n/an/an/an/an/an/an/an/a



Nektar Therapeutics

US Patent




US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50027366
PNG
(KETAZOCINE | Ketazocine | US10081602, Example Keta...)
Show SMILES C[C@H]1[C@@H]2N(CC3CC3)CC[C@@]1(C)c1cc(O)ccc1C2=O
Show InChI InChI=1S/C18H23NO2/c1-11-16-17(21)14-6-5-13(20)9-15(14)18(11,2)7-8-19(16)10-12-3-4-12/h5-6,9,11-12,16,20H,3-4,7-8,10H2,1-2H3/t11-,16-,18+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.60n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50027366
PNG
(KETAZOCINE | Ketazocine | US10081602, Example Keta...)
Show SMILES C[C@H]1[C@@H]2N(CC3CC3)CC[C@@]1(C)c1cc(O)ccc1C2=O
Show InChI InChI=1S/C18H23NO2/c1-11-16-17(21)14-6-5-13(20)9-15(14)18(11,2)7-8-19(16)10-12-3-4-12/h5-6,9,11-12,16,20H,3-4,7-8,10H2,1-2H3/t11-,16-,18+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.40n/an/an/an/an/an/a



Nektar Therapeutics

US Patent




US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM168144
PNG
(US10865186, Compound 4 | US9688638, 4 | US9688638,...)
Show SMILES COCCOCCOCCOc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C25H37NO5/c1-18-23-24(27)21-7-6-20(31-15-14-30-13-12-29-11-10-28-3)16-22(21)25(18,2)8-9-26(23)17-19-4-5-19/h6-7,16,18-19,23H,4-5,8-15,17H2,1-3H3/t18-,23-,25-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 879n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475929
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-6...)
Show SMILES COCCOCCOCCOCCOCCNc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C29H46N2O6/c1-22-27-28(32)25-7-6-24(20-26(25)29(22,2)8-10-31(27)21-23-4-5-23)30-9-11-34-14-15-36-18-19-37-17-16-35-13-12-33-3/h6-7,20,22-23,27,30H,4-5,8-19,21H2,1-3H3/t22-,27-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.38E+3n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475928
PNG
(Preparation of (2S,6R,11R)-3-(cyclopropylmethyl)-8...)
Show SMILES COCCOCCOCCN1CCN(CC1)c1ccc2C(=O)[C@@H]3[C@H](C)[C@@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C29H45N3O4/c1-22-27-28(33)25-7-6-24(20-26(25)29(22,2)8-9-32(27)21-23-4-5-23)31-12-10-30(11-13-31)14-15-35-18-19-36-17-16-34-3/h6-7,20,22-23,27H,4-5,8-19,21H2,1-3H3/t22-,27-,29+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.68E+3n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475930
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-8...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCNc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C33H54N2O8/c1-26-31-32(36)29-7-6-28(24-30(29)33(26,2)8-10-35(31)25-27-4-5-27)34-9-11-38-14-15-40-18-19-42-22-23-43-21-20-41-17-16-39-13-12-37-3/h6-7,24,26-27,31,34H,4-5,8-23,25H2,1-3H3/t26-,31-,33-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.33E+3n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475933
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-8...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C33H53NO9/c1-26-31-32(35)29-7-6-28(24-30(29)33(26,2)8-9-34(31)25-27-4-5-27)43-23-22-42-21-20-41-19-18-40-17-16-39-15-14-38-13-12-37-11-10-36-3/h6-7,24,26-27,31H,4-5,8-23,25H2,1-3H3/t26-,31-,33-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.08E+3n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM475932
PNG
(Preparation of (2S,6R,11R)-3-(Cyclopropylmethyl)-6...)
Show SMILES COCCOCCOCCOCCOCCOc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C29H45NO7/c1-22-27-28(31)25-7-6-24(20-26(25)29(22,2)8-9-30(27)21-23-4-5-23)37-19-18-36-17-16-35-15-14-34-13-12-33-11-10-32-3/h6-7,20,22-23,27H,4-5,8-19,21H2,1-3H3/t22-,27-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.28E+4n/an/an/an/an/an/a



Nektar Therapeutics

US Patent


Assay Description
The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...


US Patent US10865186 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%