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Patent code US10865206

Compile Data Set for Download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395712
PNG
(4-amino-N-((1S,3R)-3-(5-cyano-4-(1H-indol-3-yl)pyr...)
Show SMILES Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(C#N)c(n1)-c1c[nH]c2ccccc12
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US Patent
n/an/a<100n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395711
PNG
( (1S,3R)—N-(4-aminophenyl)-3-(5-chloro-4-(1H-indol...)
Show SMILES Nc1ccc(NC(=O)[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1
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n/an/a<100n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395710
PNG
(N-((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin...)
Show SMILES CN(C)CCCC(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a<100n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM475935
PNG
(US10865206, Compound 101)
Show SMILES Nc1ccc(cc1)C(=O)NC1CC(O)CC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a<100n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395718
PNG
(N1-(4-(((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyri...)
Show SMILES NC(=O)C(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395709
PNG
(4-amino-N-(5-(5-chloro-4-(1H-indol-3-yl)pyrimidin-...)
Show SMILES Nc1ccc(cc1)C(=O)NC12CC(C1)(CCC2)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H25ClN6O/c27-20-13-30-24(31-22(20)19-12-29-21-5-2-1-4-18(19)21)33-26-11-3-10-25(14-26,15-26)32-23(34)16-6-8-17(28)9-7-16/h1-2,4-9,12-13,29H,3,10-11,14-15,28H2,(H,32,34)(H,30,31,33)
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395707
PNG
(4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)py...)
Show SMILES Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395716
PNG
(4-amino-N-(1S,3R)-3-(5-chloro-4-(4H-indol-3-yl)pyr...)
Show SMILES Nc1ccc(cc1F)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395717
PNG
(4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)py...)
Show SMILES Nc1ccc(C(=O)N[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395714
PNG
(US10308648, Compound 109 | US10865206, Compound 10...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM475948
PNG
(US10865206, Compound 110)
Show SMILES Nc1ccc(cc1)C(=O)NC1CC(F)CC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395708
PNG
(4-amino-N-((1S,3R)-3-(5-cyclopropyl-4-(1H-indol-3-...)
Show SMILES Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(C2CC2)c(n1)-c1c[nH]c2ccccc12
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n/an/a 550n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM475931
PNG
(US10865206, Compound 100)
Show SMILES Nc1ccc(cc1)C(=O)NC12CC3CC(C1)CC(C3)(C2)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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n/an/a>1.00E+3n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM395713
PNG
(4-amino-N-((1S,3R)-3-(5-chloro-4-(pyridin-3-yl)pyr...)
Show SMILES Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1cccnc1
Show InChI InChI=1S/C22H23ClN6O/c23-19-13-26-22(29-20(19)15-3-2-10-25-12-15)28-18-5-1-4-17(11-18)27-21(30)14-6-8-16(24)9-7-14/h2-3,6-10,12-13,17-18H,1,4-5,11,24H2,(H,27,30)(H,26,28,29)/t17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM475952
PNG
(US10865206, Compound 114)
Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
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Syros Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...


US Patent US10865206 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%