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Patent code US10870618

Compile Data Set for Download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476626
PNG
(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Show SMILES CCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C20H23N3O2/c1-2-14-22-23-20(25)18-11-8-17(9-12-18)15-21-19(24)13-10-16-6-4-3-5-7-16/h3-13,22H,2,14-15H2,1H3,(H,21,24)(H,23,25)/b13-10+
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US Patent
n/an/a 0.950n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476611
PNG
(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)benzami...)
Show SMILES CCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H21N3O2/c1-2-12-20-21-18(23)16-10-8-14(9-11-16)13-19-17(22)15-6-4-3-5-7-15/h3-11,20H,2,12-13H2,1H3,(H,19,22)(H,21,23)
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n/an/a 3.47n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476627
PNG
(N-(4-(2-butylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C21H25N3O2/c1-2-3-15-23-24-21(26)19-12-9-18(10-13-19)16-22-20(25)14-11-17-7-5-4-6-8-17/h4-14,23H,2-3,15-16H2,1H3,(H,22,25)(H,24,26)/b14-11+
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n/an/a 3.67n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476606
PNG
(N-(4-(2-butylhydrazine-1- carbonyl)benzyl)benzamid...)
Show SMILES CCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H23N3O2/c1-2-3-13-21-22-19(24)17-11-9-15(10-12-17)14-20-18(23)16-7-5-4-6-8-16/h4-12,21H,2-3,13-14H2,1H3,(H,20,23)(H,22,24)
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n/an/a 8.56n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476626
PNG
(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Show SMILES CCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C20H23N3O2/c1-2-14-22-23-20(25)18-11-8-17(9-12-18)15-21-19(24)13-10-16-6-4-3-5-7-16/h3-13,22H,2,14-15H2,1H3,(H,21,24)(H,23,25)/b13-10+
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n/an/a 11.8n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476611
PNG
(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)benzami...)
Show SMILES CCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H21N3O2/c1-2-12-20-21-18(23)16-10-8-14(9-11-16)13-19-17(22)15-6-4-3-5-7-15/h3-11,20H,2,12-13H2,1H3,(H,19,22)(H,21,23)
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n/an/a 13.2n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476613
PNG
(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Show SMILES CCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O2/c1-2-3-7-14-22-23-20(25)18-12-10-16(11-13-18)15-21-19(24)17-8-5-4-6-9-17/h4-6,8-13,22H,2-3,7,14-15H2,1H3,(H,21,24)(H,23,25)
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n/an/a 18.7n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476606
PNG
(N-(4-(2-butylhydrazine-1- carbonyl)benzyl)benzamid...)
Show SMILES CCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H23N3O2/c1-2-3-13-21-22-19(24)17-11-9-15(10-12-17)14-20-18(23)16-7-5-4-6-8-16/h4-12,21H,2-3,13-14H2,1H3,(H,20,23)(H,22,24)
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n/an/a 18.9n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476625
PNG
(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C19H21N3O2/c1-2-21-22-19(24)17-11-8-16(9-12-17)14-20-18(23)13-10-15-6-4-3-5-7-15/h3-13,21H,2,14H2,1H3,(H,20,23)(H,22,24)/b13-10+
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n/an/a 19.7n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476613
PNG
(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Show SMILES CCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O2/c1-2-3-7-14-22-23-20(25)18-12-10-16(11-13-18)15-21-19(24)17-8-5-4-6-9-17/h4-6,8-13,22H,2-3,7,14-15H2,1H3,(H,21,24)(H,23,25)
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n/an/a 20.2n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476625
PNG
(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C19H21N3O2/c1-2-21-22-19(24)17-11-8-16(9-12-17)14-20-18(23)13-10-15-6-4-3-5-7-15/h3-13,21H,2,14H2,1H3,(H,20,23)(H,22,24)/b13-10+
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n/an/a 29.5n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476629
PNG
(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Show SMILES CCCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C22H27N3O2/c1-2-3-7-16-24-25-22(27)20-13-10-19(11-14-20)17-23-21(26)15-12-18-8-5-4-6-9-18/h4-6,8-15,24H,2-3,7,16-17H2,1H3,(H,23,26)(H,25,27)/b15-12+
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n/an/a 32.5n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476615
PNG
(N-(4-(2- (cyclopropylmethyl)hydrazine- 1-carbonyl)...)
Show SMILES O=C(NCc1ccc(cc1)C(=O)NNCC1CC1)c1ccccc1
Show InChI InChI=1S/C19H21N3O2/c23-18(16-4-2-1-3-5-16)20-12-14-8-10-17(11-9-14)19(24)22-21-13-15-6-7-15/h1-5,8-11,15,21H,6-7,12-13H2,(H,20,23)(H,22,24)
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n/an/a 39.9n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476613
PNG
(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Show SMILES CCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O2/c1-2-3-7-14-22-23-20(25)18-12-10-16(11-13-18)15-21-19(24)17-8-5-4-6-9-17/h4-6,8-13,22H,2-3,7,14-15H2,1H3,(H,21,24)(H,23,25)
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n/an/a 43.6n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476629
PNG
(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Show SMILES CCCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C22H27N3O2/c1-2-3-7-16-24-25-22(27)20-13-10-19(11-14-20)17-23-21(26)15-12-18-8-5-4-6-9-18/h4-6,8-15,24H,2-3,7,16-17H2,1H3,(H,23,26)(H,25,27)/b15-12+
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n/an/a 47.4n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476627
PNG
(N-(4-(2-butylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C21H25N3O2/c1-2-3-15-23-24-21(26)19-12-9-18(10-13-19)16-22-20(25)14-11-17-7-5-4-6-8-17/h4-14,23H,2-3,15-16H2,1H3,(H,22,25)(H,24,26)/b14-11+
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n/an/a 60.2n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476606
PNG
(N-(4-(2-butylhydrazine-1- carbonyl)benzyl)benzamid...)
Show SMILES CCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H23N3O2/c1-2-3-13-21-22-19(24)17-11-9-15(10-12-17)14-20-18(23)16-7-5-4-6-8-16/h4-12,21H,2-3,13-14H2,1H3,(H,20,23)(H,22,24)
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n/an/a 65.2n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468609
PNG
(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Show SMILES CCCCNNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-2-3-13-18-19-17(20)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a 68.8n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476614
PNG
(N-(4-(2-(3,3,3- trifluoropropyl)hydrazine-1- carbo...)
Show SMILES FC(F)(F)CCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)10-11-23-24-17(26)15-8-6-13(7-9-15)12-22-16(25)14-4-2-1-3-5-14/h1-9,23H,10-12H2,(H,22,25)(H,24,26)
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n/an/a 69.1n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476627
PNG
(N-(4-(2-butylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C21H25N3O2/c1-2-3-15-23-24-21(26)19-12-9-18(10-13-19)16-22-20(25)14-11-17-7-5-4-6-8-17/h4-14,23H,2-3,15-16H2,1H3,(H,22,25)(H,24,26)/b14-11+
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n/an/a 70n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476625
PNG
(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C19H21N3O2/c1-2-21-22-19(24)17-11-8-16(9-12-17)14-20-18(23)13-10-15-6-4-3-5-7-15/h3-13,21H,2,14H2,1H3,(H,20,23)(H,22,24)/b13-10+
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n/an/a 76.6n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476611
PNG
(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)benzami...)
Show SMILES CCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H21N3O2/c1-2-12-20-21-18(23)16-10-8-14(9-11-16)13-19-17(22)15-6-4-3-5-7-15/h3-11,20H,2,12-13H2,1H3,(H,19,22)(H,21,23)
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n/an/a 77.6n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM476630
PNG
(N-(4-(2-hexylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCCCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C23H29N3O2/c1-2-3-4-8-17-25-26-23(28)21-14-11-20(12-15-21)18-24-22(27)16-13-19-9-6-5-7-10-19/h5-7,9-16,25H,2-4,8,17-18H2,1H3,(H,24,27)(H,26,28)/b16-13+
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n/an/a 81.4n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476623
PNG
(N-(4-(2- (cyclobutylmethyl)hydrazine- 1-carbonyl)b...)
Show SMILES O=C(NCc1ccc(cc1)C(=O)NNCC1CCC1)c1ccccc1
Show InChI InChI=1S/C20H23N3O2/c24-19(17-7-2-1-3-8-17)21-13-16-9-11-18(12-10-16)20(25)23-22-14-15-5-4-6-15/h1-3,7-12,15,22H,4-6,13-14H2,(H,21,24)(H,23,25)
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n/an/a 84.4n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476626
PNG
(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Show SMILES CCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C20H23N3O2/c1-2-14-22-23-20(25)18-11-8-17(9-12-18)15-21-19(24)13-10-16-6-4-3-5-7-16/h3-13,22H,2,14-15H2,1H3,(H,21,24)(H,23,25)/b13-10+
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n/an/a 95.5n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476629
PNG
(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)cinnama...)
Show SMILES CCCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C22H27N3O2/c1-2-3-7-16-24-25-22(27)20-13-10-19(11-14-20)17-23-21(26)15-12-18-8-5-4-6-9-18/h4-6,8-15,24H,2-3,7,16-17H2,1H3,(H,23,26)(H,25,27)/b15-12+
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n/an/a 99.6n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 2


(Homo sapiens (Human))
BDBM476630
PNG
(N-(4-(2-hexylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCCCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C23H29N3O2/c1-2-3-4-8-17-25-26-23(28)21-14-11-20(12-15-21)18-24-22(27)16-13-19-9-6-5-7-10-19/h5-7,9-16,25H,2-4,8,17-18H2,1H3,(H,24,27)(H,26,28)/b16-13+
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n/an/a 139n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476630
PNG
(N-(4-(2-hexylhydrazine-1- carbonyl)benzyl)cinnamam...)
Show SMILES CCCCCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C23H29N3O2/c1-2-3-4-8-17-25-26-23(28)21-14-11-20(12-15-21)18-24-22(27)16-13-19-9-6-5-7-10-19/h5-7,9-16,25H,2-4,8,17-18H2,1H3,(H,24,27)(H,26,28)/b16-13+
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n/an/a 150n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM163623
PNG
(SR-3206 | US10807944, Compound RLS2-126 | US108706...)
Show SMILES CCCCNNC(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C12H18N2O2/c1-3-4-9-13-14-12(15)10-5-7-11(16-2)8-6-10/h5-8,13H,3-4,9H2,1-2H3,(H,14,15)
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US Patent
n/an/a 157n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476619
PNG
(N-(4-(2-hexylhydrazine-1- carbonyl)benzyl)benzamid...)
Show SMILES CCCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H27N3O2/c1-2-3-4-8-15-23-24-21(26)19-13-11-17(12-14-19)16-22-20(25)18-9-6-5-7-10-18/h5-7,9-14,23H,2-4,8,15-16H2,1H3,(H,22,25)(H,24,26)
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n/an/a 184n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476622
PNG
(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)benzamid...)
Show SMILES CCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C17H19N3O2/c1-2-19-20-17(22)15-10-8-13(9-11-15)12-18-16(21)14-6-4-3-5-7-14/h3-11,19H,2,12H2,1H3,(H,18,21)(H,20,22)
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n/an/a 187n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476602
PNG
(N'-butylcinnamohydrazide | US10870618, Compound 1i)
Show SMILES CCCCNNC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C13H18N2O/c1-2-3-11-14-15-13(16)10-9-12-7-5-4-6-8-12/h4-10,14H,2-3,11H2,1H3,(H,15,16)/b10-9+
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n/an/a 294n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476565
PNG
(N'-butyl-4- phenoxybenzohydrazide | US10870618, Co...)
Show SMILES CCCCNNC(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C17H20N2O2/c1-2-3-13-18-19-17(20)14-9-11-16(12-10-14)21-15-7-5-4-6-8-15/h4-12,18H,2-3,13H2,1H3,(H,19,20)
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n/an/a 312n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476617
PNG
(N-(4-(2-heptylhydrazine-1- carbonyl)benzyl)benzami...)
Show SMILES CCCCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C22H29N3O2/c1-2-3-4-5-9-16-24-25-22(27)20-14-12-18(13-15-20)17-23-21(26)19-10-7-6-8-11-19/h6-8,10-15,24H,2-5,9,16-17H2,1H3,(H,23,26)(H,25,27)
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n/an/a 569n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468586
PNG
(US10807944, Compound RLS2-238 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2O/c1-2-3-10-16-17-15(18)14-9-8-12-6-4-5-7-13(12)11-14/h4-9,11,16H,2-3,10H2,1H3,(H,17,18)
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n/an/a 892n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476598
PNG
(N'-butylthiophene-2- carbohydrazide | US10870618, ...)
Show SMILES CCCCNNC(=O)c1cccs1
Show InChI InChI=1S/C9H14N2OS/c1-2-3-6-10-11-9(12)8-5-4-7-13-8/h4-5,7,10H,2-3,6H2,1H3,(H,11,12)
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n/an/a 904n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476618
PNG
(N-(4-(2-octylhydrazine-1- carbonyl)benzyl)benzamid...)
Show SMILES CCCCCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-2-3-4-5-6-10-17-25-26-23(28)21-15-13-19(14-16-21)18-24-22(27)20-11-8-7-9-12-20/h7-9,11-16,25H,2-6,10,17-18H2,1H3,(H,24,27)(H,26,28)
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n/an/a 1.09E+3n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476564
PNG
(N'-butylbenzofuran-2- carbohydrazide | US10870618,...)
Show SMILES CCCCNNC(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C13H16N2O2/c1-2-3-8-14-15-13(16)12-9-10-6-4-5-7-11(10)17-12/h4-7,9,14H,2-3,8H2,1H3,(H,15,16)
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n/an/a 1.36E+3n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476607
PNG
((E)-N-(4-(2-(but-2-en-1- yl)hydrazine-1- carbonyl)...)
Show SMILES C\C=C\CNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H21N3O2/c1-2-3-13-21-22-19(24)17-11-9-15(10-12-17)14-20-18(23)16-7-5-4-6-8-16/h2-12,21H,13-14H2,1H3,(H,20,23)(H,22,24)/b3-2+
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n/an/a 1.53E+3n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM468597
PNG
(US10807944, Compound RLS2-289 | US10870618, Compou...)
Show SMILES CCCCNNC(=O)c1cccnc1
Show InChI InChI=1S/C10H15N3O/c1-2-3-7-12-13-10(14)9-5-4-6-11-8-9/h4-6,8,12H,2-3,7H2,1H3,(H,13,14)
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n/an/a 1.55E+3n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476601
PNG
(N'-butyl-3- phenylpropanehydrazide | US10870618, C...)
Show SMILES CCCCNNC(=O)CCc1ccccc1
Show InChI InChI=1S/C13H20N2O/c1-2-3-11-14-15-13(16)10-9-12-7-5-4-6-8-12/h4-8,14H,2-3,9-11H2,1H3,(H,15,16)
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n/an/a 1.89E+3n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476599
PNG
(N'-butylfuran-2- carbohydrazide | US10870618, Comp...)
Show SMILES CCCCNNC(=O)c1ccco1
Show InChI InChI=1S/C9H14N2O2/c1-2-3-6-10-11-9(12)8-5-4-7-13-8/h4-5,7,10H,2-3,6H2,1H3,(H,11,12)
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n/an/a 5.00E+3n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476610
PNG
((E)-N-(4-(2- propylidenehydrazine-1- carbonyl)benz...)
Show SMILES CC\C=N\NC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H19N3O2/c1-2-12-20-21-18(23)16-10-8-14(9-11-16)13-19-17(22)15-6-4-3-5-7-15/h3-12H,2,13H2,1H3,(H,19,22)(H,21,23)/b20-12+
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476609
PNG
(N-(4-(2-isopropylhydrazine-1- carbonyl)benzyl)benz...)
Show SMILES CC(C)NNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H21N3O2/c1-13(2)20-21-18(23)16-10-8-14(9-11-16)12-19-17(22)15-6-4-3-5-7-15/h3-11,13,20H,12H2,1-2H3,(H,19,22)(H,21,23)
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476603
PNG
(N'-butyl-1-naphthohydrazide | US10870618, Compound...)
Show SMILES CCCCNNC(=O)c1cccc2ccccc12
Show InChI InChI=1S/C15H18N2O/c1-2-3-11-16-17-15(18)14-10-6-8-12-7-4-5-9-13(12)14/h4-10,16H,2-3,11H2,1H3,(H,17,18)
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM476621
PNG
(N-(4-(2-decylhydrazine-1- carbonyl)benzyl)benzamid...)
Show SMILES CCCCCCCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C25H35N3O2/c1-2-3-4-5-6-7-8-12-19-27-28-25(30)23-17-15-21(16-18-23)20-26-24(29)22-13-10-9-11-14-22/h9-11,13-18,27H,2-8,12,19-20H2,1H3,(H,26,29)(H,28,30)
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

US Patent


Assay Description
Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...


US Patent US10870618 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%