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Patent code US10870635

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476688
PNG
((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H22N2O2S2/c1-5-6-14-7-9-18-16(11-14)17-12-15(8-10-19(17)27-18)22(4)13-28(25,26)21(2,3)20(23)24-22/h7-12H,13H2,1-4H3,(H2,23,24)/t22-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476692
PNG
((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CC#Cc1ccc2sc3cc(F)c(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H21FN2O2S2/c1-5-6-13-7-8-18-14(9-13)15-10-16(17(23)11-19(15)28-18)22(4)12-29(26,27)21(2,3)20(24)25-22/h7-11H,12H2,1-4H3,(H2,24,25)/t22-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476679
PNG
((S)-6-(8-(3-Hydroxyprop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CN1C(=N)N[C@@](C)(CC1=O)c1ccc2sc3ccc(cc3c2c1)C#CCO
Show InChI InChI=1S/C21H19N3O2S/c1-21(12-19(26)24(2)20(22)23-21)14-6-8-18-16(11-14)15-10-13(4-3-9-25)5-7-17(15)27-18/h5-8,10-11,25H,9,12H2,1-2H3,(H2,22,23)/t21-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476666
PNG
((S)-6-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CC#Cc1ccc2sc3cc(F)c(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H18FN3OS/c1-4-5-12-6-7-17-13(8-12)14-9-15(16(22)10-18(14)27-17)21(2)11-19(26)25(3)20(23)24-21/h6-10H,11H2,1-3H3,(H2,23,24)/t21-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476661
PNG
((S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)...)
Show SMILES CC#Cc1ccc2[nH]c(c(Cl)c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
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n/an/a 24n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476692
PNG
((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CC#Cc1ccc2sc3cc(F)c(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H21FN2O2S2/c1-5-6-13-7-8-18-14(9-13)15-10-16(17(23)11-19(15)28-18)22(4)12-29(26,27)21(2,3)20(24)25-22/h7-11H,12H2,1-4H3,(H2,24,25)/t22-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476692
PNG
((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CC#Cc1ccc2sc3cc(F)c(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H21FN2O2S2/c1-5-6-13-7-8-18-14(9-13)15-10-16(17(23)11-19(15)28-18)22(4)12-29(26,27)21(2,3)20(24)25-22/h7-11H,12H2,1-4H3,(H2,24,25)/t22-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476660
PNG
((S)-2-Imino-3,6-dimethyl-6-(8-(prop- 1-yn-1-yl)dib...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H19N3OS/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)26-17)21(2)12-19(25)24(3)20(22)23-21/h6-11H,12H2,1-3H3,(H2,22,23)/t21-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476660
PNG
((S)-2-Imino-3,6-dimethyl-6-(8-(prop- 1-yn-1-yl)dib...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H19N3OS/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)26-17)21(2)12-19(25)24(3)20(22)23-21/h6-11H,12H2,1-3H3,(H2,22,23)/t21-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476688
PNG
((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H22N2O2S2/c1-5-6-14-7-9-18-16(11-14)17-12-15(8-10-19(17)27-18)22(4)13-28(25,26)21(2,3)20(23)24-22/h7-12H,13H2,1-4H3,(H2,23,24)/t22-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476688
PNG
((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H22N2O2S2/c1-5-6-14-7-9-18-16(11-14)17-12-15(8-10-19(17)27-18)22(4)13-28(25,26)21(2,3)20(23)24-22/h7-12H,13H2,1-4H3,(H2,23,24)/t22-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476688
PNG
((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H22N2O2S2/c1-5-6-14-7-9-18-16(11-14)17-12-15(8-10-19(17)27-18)22(4)13-28(25,26)21(2,3)20(23)24-22/h7-12H,13H2,1-4H3,(H2,23,24)/t22-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476694
PNG
((S)-6-(3-Chloro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CC#Cc1ccc2sc3cc(Cl)c(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H18ClN3OS/c1-4-5-12-6-7-17-13(8-12)14-9-15(16(22)10-18(14)27-17)21(2)11-19(26)25(3)20(23)24-21/h6-10H,11H2,1-3H3,(H2,23,24)/t21-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476661
PNG
((S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)...)
Show SMILES CC#Cc1ccc2[nH]c(c(Cl)c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
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n/an/a 44n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476673
PNG
((6S)-2-Imino-3,6-dimethyl-6-(5-oxido-8- (prop-1-yn...)
Show SMILES CC#Cc1ccc2c(c1)c1cc(ccc1s2=O)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H19N3O2S/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)27(17)26)21(2)12-19(25)24(3)20(22)23-21/h6-11H,12H2,1-3H3,(H2,22,23)/t21-,27?/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476682
PNG
((S)-6-(8-Cyclopropyldibenzo[b,d] thiophen-2-yl)-2-...)
Show SMILES CN1C(=N)N[C@@](C)(CC1=O)c1ccc2sc3ccc(cc3c2c1)C1CC1
Show InChI InChI=1S/C21H21N3OS/c1-21(11-19(25)24(2)20(22)23-21)14-6-8-18-16(10-14)15-9-13(12-3-4-12)5-7-17(15)26-18/h5-10,12H,3-4,11H2,1-2H3,(H2,22,23)/t21-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476685
PNG
((S)-2-Imino-3,6-dimethyl-6-(8-(trifluoro- methyl)d...)
Show SMILES CN1C(=N)N[C@@](C)(CC1=O)c1ccc2sc3ccc(cc3c2c1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3OS/c1-18(9-16(26)25(2)17(23)24-18)10-3-5-14-12(7-10)13-8-11(19(20,21)22)4-6-15(13)27-14/h3-8H,9H2,1-2H3,(H2,23,24)/t18-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476670
PNG
((S)-6-(5,5-Dioxido-8-(prop-1-yn-1-yl) dibenzo[b,d]...)
Show SMILES CC#Cc1ccc2c(c1)-c1cc(ccc1S2(=O)=O)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H19N3O3S/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)28(17,26)27)21(2)12-19(25)24(3)20(22)23-21/h6-11H,12H2,1-3H3,(H2,22,23)/t21-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476687
PNG
((R)-5,5-Difluoro-4-methyl-4-(8-(prop- 1-yn-1-yl)di...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@@]1(C)NC(=N)OCC1(F)F
Show InChI InChI=1S/C20H16F2N2OS/c1-3-4-12-5-7-16-14(9-12)15-10-13(6-8-17(15)26-16)19(2)20(21,22)11-25-18(23)24-19/h5-10H,11H2,1-2H3,(H2,23,24)/t19-/m1/s1
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n/an/a 202n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476678
PNG
((S)-2-Imino-6-(8-(3-methoxyprop-1- yn-1-yl)dibenzo...)
Show SMILES COCC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C22H21N3O2S/c1-22(13-20(26)25(2)21(23)24-22)15-7-9-19-17(12-15)16-11-14(5-4-10-27-3)6-8-18(16)28-19/h6-9,11-12H,10,13H2,1-3H3,(H2,23,24)/t22-/m0/s1
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n/an/a 218n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476684
PNG
((S)-6-(8-(Diethylamino)dibenzo[b,d] thiophen-2-yl)...)
Show SMILES CCN(CC)c1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C22H26N4OS/c1-5-26(6-2)15-8-10-19-17(12-15)16-11-14(7-9-18(16)28-19)22(3)13-20(27)25(4)21(23)24-22/h7-12H,5-6,13H2,1-4H3,(H2,23,24)/t22-/m0/s1
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n/an/a>300n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476683
PNG
((S)-8-(2-Imino-1,4-dimethyl-6- oxohexahydropyrimid...)
Show SMILES CN1C(=N)N[C@@](C)(CC1=O)c1ccc2sc3ccc(cc3c2c1)C(N)=O
Show InChI InChI=1S/C19H18N4O2S/c1-19(9-16(24)23(2)18(21)22-19)11-4-6-15-13(8-11)12-7-10(17(20)25)3-5-14(12)26-15/h3-8H,9H2,1-2H3,(H2,20,25)(H2,21,22)/t19-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476693
PNG
((R)-3-Imino-1,5-dimethyl-5-(8-(prop- 1-yn-1-yl)dib...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CN(C)C(=O)C(=N)N1
Show InChI InChI=1S/C21H19N3OS/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)26-17)21(2)12-24(3)20(25)19(22)23-21/h6-11H,12H2,1-3H3,(H2,22,23)/t21-/m0/s1
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n/an/a>300n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476680
PNG
((S)-6-(8-Bromodibenzo[b,d]thiophen- 2-yl)-2-imino-...)
Show SMILES CN1C(=N)N[C@@](C)(CC1=O)c1ccc2sc3ccc(Br)cc3c2c1
Show InChI InChI=1S/C18H16BrN3OS/c1-18(9-16(23)22(2)17(20)21-18)10-3-5-14-12(7-10)13-8-11(19)4-6-15(13)24-14/h3-8H,9H2,1-2H3,(H2,20,21)/t18-/m0/s1
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n/an/a>300n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476677
PNG
((S)-8-(2-Imino-1,4-dimethyl-6- oxohexahydropyrimid...)
Show SMILES CN1C(=N)N[C@@](C)(CC1=O)c1ccc2sc3ccc(cc3c2c1)C#N
Show InChI InChI=1S/C19H16N4OS/c1-19(9-17(24)23(2)18(21)22-19)12-4-6-16-14(8-12)13-7-11(10-20)3-5-15(13)25-16/h3-8H,9H2,1-2H3,(H2,21,22)/t19-/m0/s1
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n/an/a>300n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476690
PNG
((S)-3-(2,2-Difluoroethyl)-2-imino-6- methyl-6-(8-(...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(CC(F)F)C(=N)N1
Show InChI InChI=1S/C22H19F2N3OS/c1-3-4-13-5-7-17-15(9-13)16-10-14(6-8-18(16)29-17)22(2)11-20(28)27(12-19(23)24)21(25)26-22/h5-10,19H,11-12H2,1-2H3,(H2,25,26)/t22-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476675
PNG
((S)-6-(9,9-Dimethyl-6-(prop-1-yn-1-yl)- 9H-fluoren...)
Show SMILES CC#Cc1ccc2c(c1)-c1cc(ccc1C2(C)C)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C24H25N3O/c1-6-7-15-8-10-19-17(12-15)18-13-16(9-11-20(18)23(19,2)3)24(4)14-21(28)27(5)22(25)26-24/h8-13H,14H2,1-5H3,(H2,25,26)/t24-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476686
PNG
((R)-6-Cyclopropyl-2-imino-3-methyl- 6-(8-(prop-1-y...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@@]1(CC(=O)N(C)C(=N)N1)C1CC1
Show InChI InChI=1S/C23H21N3OS/c1-3-4-14-5-9-19-17(11-14)18-12-16(8-10-20(18)28-19)23(15-6-7-15)13-21(27)26(2)22(24)25-23/h5,8-12,15H,6-7,13H2,1-2H3,(H2,24,25)/t23-/m1/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476681
PNG
((S)-2-Imino-3,6-dimethyl-6-(8-propyl- dibenzo[b,d]...)
Show SMILES CCCc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H23N3OS/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)26-17)21(2)12-19(25)24(3)20(22)23-21/h6-11H,4-5,12H2,1-3H3,(H2,22,23)/t21-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476676
PNG
((S)-6-(9,9-Difluoro-6-(prop-1-yn-1-yl)- 9H-fluoren...)
Show SMILES CC#Cc1ccc2c(c1)-c1cc(ccc1C2(F)F)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C22H19F2N3O/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)22(17,23)24)21(2)12-19(28)27(3)20(25)26-21/h6-11H,12H2,1-3H3,(H2,25,26)/t21-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476691
PNG
((S)-2-Imino-3-(2-methoxyethyl)-6- methyl-6-(8-(pro...)
Show SMILES COCCN1C(=N)N[C@@](C)(CC1=O)c1ccc2sc3ccc(cc3c2c1)C#CC
Show InChI InChI=1S/C23H23N3O2S/c1-4-5-15-6-8-19-17(12-15)18-13-16(7-9-20(18)29-19)23(2)14-21(27)26(10-11-28-3)22(24)25-23/h6-9,12-13H,10-11,14H2,1-3H3,(H2,24,25)/t23-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Beta-secretase (BACE)


(Homo sapiens (Human))
BDBM476689
PNG
((R)-3-Imino-2,5-dimethyl-5-(8-(prop- 1-yn-1-yl)dib...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1
Show InChI InChI=1S/C20H19N3O2S2/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)26-17)20(2)12-27(24,25)23(3)19(21)22-20/h6-11H,12H2,1-3H3,(H2,21,22)/t20-/m0/s1
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ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (Human))
BDBM476694
PNG
((S)-6-(3-Chloro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CC#Cc1ccc2sc3cc(Cl)c(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H18ClN3OS/c1-4-5-12-6-7-17-13(8-12)14-9-15(16(22)10-18(14)27-17)21(2)11-19(26)25(3)20(23)24-21/h6-10H,11H2,1-3H3,(H2,23,24)/t21-/m0/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (Human))
BDBM476692
PNG
((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Show SMILES CC#Cc1ccc2sc3cc(F)c(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H21FN2O2S2/c1-5-6-13-7-8-18-14(9-13)15-10-16(17(23)11-19(15)28-18)22(4)12-29(26,27)21(2,3)20(24)25-22/h7-11H,12H2,1-4H3,(H2,24,25)/t22-/m0/s1
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n/an/a 1.08E+4n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (Human))
BDBM476660
PNG
((S)-2-Imino-3,6-dimethyl-6-(8-(prop- 1-yn-1-yl)dib...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1
Show InChI InChI=1S/C21H19N3OS/c1-4-5-13-6-8-17-15(10-13)16-11-14(7-9-18(16)26-17)21(2)12-19(25)24(3)20(22)23-21/h6-11H,12H2,1-3H3,(H2,22,23)/t21-/m0/s1
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n/an/a 1.23E+4n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (Human))
BDBM476688
PNG
((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Show SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1
Show InChI InChI=1S/C22H22N2O2S2/c1-5-6-14-7-9-18-16(11-14)17-12-15(8-10-19(17)27-18)22(4)13-28(25,26)21(2,3)20(23)24-22/h7-12H,13H2,1-4H3,(H2,23,24)/t22-/m0/s1
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n/an/a 1.72E+4n/an/an/an/an/an/a



ALLGENESIS BIOTHERAPEUTICS, INC.

US Patent


Assay Description
Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...


US Patent US10870635 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%