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Found 27 Enz. Inhib. hit(s) with all data for entry = 9611
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476709(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Affinity DataIC50:  0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476704( (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-di...)
Affinity DataIC50:  0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476704( (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-di...)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50:  1.10nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50:  1.20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50:  1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476711( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Affinity DataIC50:  1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476699((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50:  1.90nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476711( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Affinity DataIC50:  2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476710((R)-5-chloro-N-(3-cyclopropyl-5-((3,3,5-trimethylp...)
Affinity DataIC50:  2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476708(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50:  2.40nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50:  2.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476697(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Affinity DataIC50:  3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476701(US10870639, Example 10 | US11292786, Example 10 | ...)
Affinity DataIC50:  3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50:  3.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476712((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl...)
Affinity DataIC50:  6.90nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476698(2-((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3...)
Affinity DataIC50:  7.20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476696(2-((2R,6S)-4-(3-((5-chloro-4-(6-fluoro-1H-indole-3...)
Affinity DataIC50:  8.10nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476703(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50:  8.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476705(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50:  9.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50:  13nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476710((R)-5-chloro-N-(3-cyclopropyl-5-((3,3,5-trimethylp...)
Affinity DataIC50:  20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476709(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Affinity DataIC50: >50nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476707(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: >50nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476705(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50: >50nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent