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Patent code US10870641

Compile Data Set for Download or QSAR

Found 855 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431530
PNG
(US10550105, Example 475 | US10870641, Example 475)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1COCCC(=O)N1CCN(CC1)c1ccc(nc1)C#N
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431532
PNG
(US10550105, Example 477 | US10870641, Example 477)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC(COc2ccc(cc2)C(=O)N2CCN(CC2)c2ccc(cn2)C#N)C1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431547
PNG
(US10550105, Example 492 | US10870641, Example 492)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2cccc(OCCNCCC(=O)N3CCN(CC3)c3ccc(cn3)C#N)c2C1
Show InChI InChI=1S/C28H29F3N8O3/c29-28(30,31)26-22(16-35-36-27(26)41)39-17-20-2-1-3-23(21(20)18-39)42-13-8-33-7-6-25(40)38-11-9-37(10-12-38)24-5-4-19(14-32)15-34-24/h1-5,15-16,33H,6-13,17-18H2,(H,36,41)
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431558
PNG
(5-[(2-[3-[4-(5-Chloropyrimidin-2-yl)piperazin-1-yl...)
Show SMILES FC(F)(F)c1c(NCCOCCC(=O)N2CCN(CC2)c2ncc(Cl)cn2)cn[nH]c1=O
Show InChI InChI=1S/C18H21ClF3N7O3/c19-12-9-24-17(25-10-12)29-5-3-28(4-6-29)14(30)1-7-32-8-2-23-13-11-26-27-16(31)15(13)18(20,21)22/h9-11H,1-8H2,(H2,23,27,31)
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431590
PNG
(6-[4-[3-(3-Hydroxy-2-[[6-oxo-5-(trifluoromethyl)-1...)
Show SMILES OCC(COCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM477297
PNG
(US10870641, Example 532A)
Show SMILES COC[C@@H](COCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)Oc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431601
PNG
(US10550105, Example 536 | US10870641, Example 536)
Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)CCOCCOc1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C20H21F6N5O4/c21-19(22,23)13-1-2-15(27-11-13)30-4-6-31(7-5-30)16(32)3-8-34-9-10-35-14-12-28-29-18(33)17(14)20(24,25)26/h1-2,11-12H,3-10H2,(H,29,33)
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431608
PNG
(US10550105, Example 539C | US10870641, Example 539...)
Show SMILES C[C@H](COc1cn[nH]c(=O)c1C(F)(F)F)OCCC(=O)N1CCN(CC1)c1ccc(Cl)cn1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431633
PNG
(US10550105, Example 551 | US10870641, Example 551)
Show SMILES Cc1c(OCCOCCC(=O)N2CCN(CC2)c2ccc(cn2)C#N)cn[nH]c1=O
Show InChI InChI=1S/C20H24N6O4/c1-15-17(14-23-24-20(15)28)30-11-10-29-9-4-19(27)26-7-5-25(6-8-26)18-3-2-16(12-21)13-22-18/h2-3,13-14H,4-11H2,1H3,(H,24,28)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM477343
PNG
(US10870641, Example 560A)
Show SMILES CO[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1)Oc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431645
PNG
(US10550105, Example 560D | US10870641, Example 560...)
Show SMILES COC[C@@H](COc1cn[nH]c(=O)c1C(F)(F)F)OCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431720
PNG
(6-(4-[3-[(2S)-3-Methyl-2-[[6-oxo-5-(trifluoromethy...)
Show SMILES CC(C)[C@@H](COCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431727
PNG
(4-Bromo-5-[[(2S)-1-(3-oxo-3-[4-[5-(trifluoromethyl...)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1)Nc1cn[nH]c(=O)c1Br
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431728
PNG
(5-[[(2S)-1-Hydroxy-3-(3-oxo-3-[4-[5-(trifluorometh...)
Show SMILES OC[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431744
PNG
(US10550105, Example 614C | US10870641, Example 614...)
Show SMILES FC(F)(F)c1cnc(nc1)N1CCN(CC1)C(=O)CCOC[C@@H](Nc1cn[nH]c(=O)c1C(F)(F)F)[C@H]1CCOC1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431749
PNG
(US10550105, Example 617B | US10870641, Example 617...)
Show SMILES C[C@@H](COC[C@@H](N)CC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431769
PNG
(US10550105, Example 635 | US10870641, Example 635)
Show SMILES C[C@H](O)[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431785
PNG
(US10550105, Example 651 | US10870641, Example 651)
Show SMILES COC[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1Cl
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431788
PNG
(US10550105, Example 654 | US10870641, Example 654)
Show SMILES FC(F)(F)c1cnc(nc1)N1CCN(CC1)C(=O)CCOC[C@H](Nc1cn[nH]c(=O)c1C(F)(F)F)C1CCNCC1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431733
PNG
(4-Bromo-5-[[(2S)-1-(3-oxo-3-[4-[5-(trifluoromethyl...)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Oc1cn[nH]c(=O)c1Br
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431804
PNG
(US10550105, Example 670 | US10870641, Example 687)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(C)cn1)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431808
PNG
(US10550105, Example 674 | US10870641, Example 674)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431829
PNG
(US10550105, Example 696 | US10870641, Example 696)
Show SMILES COC[C@@H](COCCC(=O)N1CCN(CC1)c1cnc(Cl)cn1)Oc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431845
PNG
(US10550105, Example 712 | US10870641, Example 712)
Show SMILES COC[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(s1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431854
PNG
(US10550105, Example 721 | US10870641, Example 721)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(Cl)s1)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431855
PNG
(US10550105, Example 722 | US10870641, Example 722)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1nnc(s1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431860
PNG
(US10550105, Example 727 | US10870641, Example 727)
Show SMILES CC[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1)Oc1cn[nH]c(=O)c1Br
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431866
PNG
(US10550105, Example 733 | US10870641, Example 733)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(C)s1)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431099
PNG
(6-[4-(4-[[(2S)-1-[6-oxo-5-(trifluoromethyl)-1,6-di...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1COCCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431100
PNG
(6-[4-(3-[[(2S,4S)-4-methyl-1-[6-oxo-5-(trifluorome...)
Show SMILES C[C@H]1C[C@@H](COCCC(=O)N2CCN(CC2)c2ccc(cn2)C#N)N(C1)c1cn[nH]c(=O)c1C(F)(F)F
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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM476803
PNG
(US10870641, Example 79B | US10870641, Example 79C ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2[C@@H]1COC\C=C\C(=O)N1CCN(CC1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431109
PNG
(US10550105, Example 82A | US10870641, Example 82A)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1CO[C@H]1CC[C@@H](CC1)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431117
PNG
(6-[4-[2-([2-[(2S)-1-[6-oxo-5-(trifluoromethyl)-1,6...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1CCNCC(=O)N1CCN(CC1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431130
PNG
(6-[4-(3-[[(2S)-1-[6-Oxo-5-(trifluoromethyl)-1,6-di...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1COCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431147
PNG
((S)-6-[5-(3-[[1-[6-oxo-5-(trifluoromethyl)-1,6-dih...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1COCCC(=O)N1CC2CN(CC2C1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431150
PNG
(6-[[1-(3-[[(2S)-1-[6-oxo-5-(trifluoromethyl)-1,6-d...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1COCCC(=O)N1CCC(CC1)Nc1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431189
PNG
(US10550105, Example 145A | US10550105, Example 145...)
Show SMILES N[C@H](COC[C@@H]1CCCN1c1cn[nH]c(=O)c1C(F)(F)F)CC(=O)N1CCN(CC1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431032
PNG
(5-[5-fluoro-6-(piperidin-4-ylmethoxy)-2,3-dihydro-...)
Show SMILES Fc1cc2CN(Cc2cc1OCC1CCNCC1)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C19H20F4N4O2/c20-14-5-12-8-27(15-7-25-26-18(28)17(15)19(21,22)23)9-13(12)6-16(14)29-10-11-1-3-24-4-2-11/h5-7,11,24H,1-4,8-10H2,(H,26,28)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431215
PNG
(US10550105, Example 160 | US10870641, Example 160)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H10F3N3O/c14-13(15,16)11-10(5-17-18-12(11)20)19-6-8-3-1-2-4-9(8)7-19/h1-5H,6-7H2,(H,18,20)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431235
PNG
(US10550105, Example 180 | US10870641, Example 180)
Show SMILES Fc1cccc2CN(Cc12)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C13H9F4N3O/c14-9-3-1-2-7-5-20(6-8(7)9)10-4-18-19-12(21)11(10)13(15,16)17/h1-4H,5-6H2,(H,19,21)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431236
PNG
(US10550105, Example 181 | US10870641, Example 181)
Show SMILES OCCOc1cccc2CN(Cc12)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C15H14F3N3O3/c16-15(17,18)13-11(6-19-20-14(13)23)21-7-9-2-1-3-12(10(9)8-21)24-5-4-22/h1-3,6,22H,4-5,7-8H2,(H,20,23)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431247
PNG
(US10550105, Example 192 | US10870641, Example 192)
Show SMILES CCOc1cccc2CN(Cc12)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C15H14F3N3O2/c1-2-23-12-5-3-4-9-7-21(8-10(9)12)11-6-19-20-14(22)13(11)15(16,17)18/h3-6H,2,7-8H2,1H3,(H,20,22)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431047
PNG
(6-[2-oxo-4-[(3-[[(2S)-1-[6-oxo-5-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1COc1cccc(c1)C(=O)N1CCN(C(=O)C1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431046
PNG
(6-[3-(hydroxymethyl)-4-[(3-[[(2S)-[[6-oxo-5-(trifl...)
Show SMILES OCC1CN(CCN1C(=O)c1cccc(OC[C@@H]2CCCN2c2cn[nH]c(=O)c2C(F)(F)F)c1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431053
PNG
(US10550105, Example 38A | US10870641, Example 38A)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2[C@H]1COc1nccc(n1)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431065
PNG
(5-[5-fluoro-6-[(1-methylpyrrolidin-2-yl)methoxy]-2...)
Show SMILES CN1CCCC1COc1cc2CN(Cc2cc1F)c1cn[nH]c(=O)c1C(F)(F)F
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431070
PNG
(5-(5-(1-acetylpyrrolidin-3-yloxy)-6-fluoroisoindol...)
Show SMILES CC(=O)N1CCC(C1)Oc1cc2CN(Cc2cc1F)c1cn[nH]c(=O)c1C(F)(F)F
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431266
PNG
(US10550105, Example 211 | US10870641, Example 211)
Show SMILES CC(=O)NCCOc1cccc2CN(Cc12)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C17H17F3N4O3/c1-10(25)21-5-6-27-14-4-2-3-11-8-24(9-12(11)14)13-7-22-23-16(26)15(13)17(18,19)20/h2-4,7H,5-6,8-9H2,1H3,(H,21,25)(H,23,26)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431269
PNG
(US10550105, Example 214 | US10870641, Example 214)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2cccc(OCCN3CCOCC3)c2C1
Show InChI InChI=1S/C19H21F3N4O3/c20-19(21,22)17-15(10-23-24-18(17)27)26-11-13-2-1-3-16(14(13)12-26)29-9-6-25-4-7-28-8-5-25/h1-3,10H,4-9,11-12H2,(H,24,27)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431281
PNG
(US10550105, Example 226 | US10870641, Example 226)
Show SMILES CN1CCN(CCOc2cccc3CN(Cc23)c2cn[nH]c(=O)c2C(F)(F)F)CC1
Show InChI InChI=1S/C20H24F3N5O2/c1-26-5-7-27(8-6-26)9-10-30-17-4-2-3-14-12-28(13-15(14)17)16-11-24-25-19(29)18(16)20(21,22)23/h2-4,11H,5-10,12-13H2,1H3,(H,25,29)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US10870641 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%