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Patent code US10874634

Compile Data Set for Download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476230
PNG
(US10874634, Cmpd No. 12)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(cc1)C(C)(C)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H33NO4S/c1-16-14-19-20(24(4,5)13-12-23(19,2)3)15-21(16)31(29,30)26-18-10-8-17(9-11-18)25(6,7)22(27)28/h8-11,14-15,26H,12-13H2,1-7H3,(H,27,28)
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n/an/a 100n/an/an/an/an/an/a



Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476235
PNG
(US10874634, Cmpd No. 17)
Show SMILES CCC(CC)(C(O)=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C26H35NO4S/c1-7-26(8-2,23(28)29)18-9-11-19(12-10-18)27-32(30,31)20-13-14-21-22(17-20)25(5,6)16-15-24(21,3)4/h9-14,17,27H,7-8,15-16H2,1-6H3,(H,28,29)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476224
PNG
(US10874634, Cmpd No. 07)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H29NO4S/c1-15-12-18-19(23(4,5)11-10-22(18,2)3)14-20(15)29(27,28)24-17-8-6-16(7-9-17)13-21(25)26/h6-9,12,14,24H,10-11,13H2,1-5H3,(H,25,26)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476228
PNG
(US10874634, Cmpd No. 10)
Show SMILES Cc1cc2c(c(C)c1C(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H31NO3/c1-15-13-19-22(25(5,6)12-11-24(19,3)4)16(2)21(15)23(29)26-18-9-7-17(8-10-18)14-20(27)28/h7-10,13H,11-12,14H2,1-6H3,(H,26,29)(H,27,28)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476237
PNG
(US10874634, Cmpd No. 19)
Show SMILES CC(C)C(C(O)=O)c1ccc(NS(=O)(=O)c2cc3c(cc2C)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C26H35NO4S/c1-16(2)23(24(28)29)18-8-10-19(11-9-18)27-32(30,31)22-15-21-20(14-17(22)3)25(4,5)12-13-26(21,6)7/h8-11,14-16,23,27H,12-13H2,1-7H3,(H,28,29)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476180
PNG
(US10874634, Cmpd No. 02)
Show SMILES Cc1cc2c(cc1C(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO3/c1-15-12-19-20(24(4,5)11-10-23(19,2)3)14-18(15)22(28)25-17-8-6-16(7-9-17)13-21(26)27/h6-9,12,14H,10-11,13H2,1-5H3,(H,25,28)(H,26,27)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476217
PNG
(US10874634, Cmpd No. 04)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)Nc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C22H27NO4S/c1-21(2)11-12-22(3,4)19-14-17(9-10-18(19)21)28(26,27)23-16-7-5-15(6-8-16)13-20(24)25/h5-10,14,23H,11-13H2,1-4H3,(H,24,25)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476223
PNG
(US10874634, Cmpd No. 06)
Show SMILES CC(C)c1cc2c(cc1C(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H33NO3/c1-16(2)19-14-21-22(26(5,6)12-11-25(21,3)4)15-20(19)24(30)27-18-9-7-17(8-10-18)13-23(28)29/h7-10,14-16H,11-13H2,1-6H3,(H,27,30)(H,28,29)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476234
PNG
(US10874634, Cmpd No. 16)
Show SMILES Cc1cc2c(cc1C(=O)Nc1ccc(cc1)C(C)(C)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H33NO3/c1-16-14-20-21(25(4,5)13-12-24(20,2)3)15-19(16)22(28)27-18-10-8-17(9-11-18)26(6,7)23(29)30/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)(H,29,30)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476238
PNG
(US10874634, Cmpd No. 21)
Show SMILES Cc1ccc(NS(=O)(=O)c2cc(C)c3OC(C)(C)CC(C)(C)c3c2)cc1
Show InChI InChI=1S/C21H27NO3S/c1-14-7-9-16(10-8-14)22-26(23,24)17-11-15(2)19-18(12-17)20(3,4)13-21(5,6)25-19/h7-12,22H,13H2,1-6H3
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476180
PNG
(US10874634, Cmpd No. 02)
Show SMILES Cc1cc2c(cc1C(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO3/c1-15-12-19-20(24(4,5)11-10-23(19,2)3)14-18(15)22(28)25-17-8-6-16(7-9-17)13-21(26)27/h6-9,12,14H,10-11,13H2,1-5H3,(H,25,28)(H,26,27)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476226
PNG
(US10874634, Cmpd No. 09)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)Nc1ccc(CC(O)=O)c(F)c1
Show InChI InChI=1S/C22H26FNO4S/c1-21(2)9-10-22(3,4)18-13-16(7-8-17(18)21)29(27,28)24-15-6-5-14(11-20(25)26)19(23)12-15/h5-8,12-13,24H,9-11H2,1-4H3,(H,25,26)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476225
PNG
(US10874634, Cmpd No. 08)
Show SMILES CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(CC(O)=O)cc3)ccc12
Show InChI InChI=1S/C23H27NO3/c1-22(2)11-12-23(3,4)19-14-17(9-10-18(19)22)24-21(27)16-7-5-15(6-8-16)13-20(25)26/h5-10,14H,11-13H2,1-4H3,(H,24,27)(H,25,26)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476173
PNG
(US10874634, Cmpd No. 01)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C23H27NO3/c1-22(2)11-12-23(3,4)19-14-16(7-10-18(19)22)21(27)24-17-8-5-15(6-9-17)13-20(25)26/h5-10,14H,11-13H2,1-4H3,(H,24,27)(H,25,26)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476231
PNG
(US10874634, Cmpd No. 13)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(cc1)C1(CC1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H31NO4S/c1-16-14-19-20(24(4,5)11-10-23(19,2)3)15-21(16)31(29,30)26-18-8-6-17(7-9-18)25(12-13-25)22(27)28/h6-9,14-15,26H,10-13H2,1-5H3,(H,27,28)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476228
PNG
(US10874634, Cmpd No. 10)
Show SMILES Cc1cc2c(c(C)c1C(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H31NO3/c1-15-13-19-22(25(5,6)12-11-24(19,3)4)16(2)21(15)23(29)26-18-9-7-17(8-10-18)14-20(27)28/h7-10,13H,11-12,14H2,1-6H3,(H,26,29)(H,27,28)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476221
PNG
(US10874634, Cmpd No. 04B)
Show SMILES COC(C)Cc1ccc(NS(=O)(=O)C2=CC3C(C=C2Br)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C24H34BrNO3S/c1-16(29-6)13-17-7-9-18(10-8-17)26-30(27,28)22-15-20-19(14-21(22)25)23(2,3)11-12-24(20,4)5/h7-10,14-16,19-20,26H,11-13H2,1-6H3
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476173
PNG
(US10874634, Cmpd No. 01)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C23H27NO3/c1-22(2)11-12-23(3,4)19-14-16(7-10-18(19)22)21(27)24-17-8-5-15(6-9-17)13-20(25)26/h5-10,14H,11-13H2,1-4H3,(H,24,27)(H,25,26)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476236
PNG
(US10874634, Cmpd No. 18)
Show SMILES CCC(CC)(C(O)=O)c1ccc(NS(=O)(=O)c2cc3c(cc2C)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C27H37NO4S/c1-8-27(9-2,24(29)30)19-10-12-20(13-11-19)28-33(31,32)23-17-22-21(16-18(23)3)25(4,5)14-15-26(22,6)7/h10-13,16-17,28H,8-9,14-15H2,1-7H3,(H,29,30)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476222
PNG
(US10874634, Cmpd No. 05)
Show SMILES CC1(C)CCOc2ccc(cc12)C(=O)Nc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C20H21NO4/c1-20(2)9-10-25-17-8-5-14(12-16(17)20)19(24)21-15-6-3-13(4-7-15)11-18(22)23/h3-8,12H,9-11H2,1-2H3,(H,21,24)(H,22,23)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476234
PNG
(US10874634, Cmpd No. 16)
Show SMILES Cc1cc2c(cc1C(=O)Nc1ccc(cc1)C(C)(C)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H33NO3/c1-16-14-20-21(25(4,5)13-12-24(20,2)3)15-19(16)22(28)27-18-10-8-17(9-11-18)26(6,7)23(29)30/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)(H,29,30)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476218
PNG
(US10874634, Cmpd No. 04A)
Show SMILES COC(=C)Cc1ccc(NS(=O)(=O)C2=CC3C(C=C2)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C24H33NO3S/c1-17(28-6)15-18-7-9-19(10-8-18)25-29(26,27)20-11-12-21-22(16-20)24(4,5)14-13-23(21,2)3/h7-12,16,21-22,25H,1,13-15H2,2-6H3
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476226
PNG
(US10874634, Cmpd No. 09)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)Nc1ccc(CC(O)=O)c(F)c1
Show InChI InChI=1S/C22H26FNO4S/c1-21(2)9-10-22(3,4)18-13-16(7-8-17(18)21)29(27,28)24-15-6-5-14(11-20(25)26)19(23)12-15/h5-8,12-13,24H,9-11H2,1-4H3,(H,25,26)
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n/an/a 1.42E+4n/an/an/an/an/an/a



Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476217
PNG
(US10874634, Cmpd No. 04)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)Nc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C22H27NO4S/c1-21(2)11-12-22(3,4)19-14-17(9-10-18(19)21)28(26,27)23-16-7-5-15(6-8-16)13-20(24)25/h5-10,14,23H,11-13H2,1-4H3,(H,24,25)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476225
PNG
(US10874634, Cmpd No. 08)
Show SMILES CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(CC(O)=O)cc3)ccc12
Show InChI InChI=1S/C23H27NO3/c1-22(2)11-12-23(3,4)19-14-17(9-10-18(19)22)24-21(27)16-7-5-15(6-8-16)13-20(25)26/h5-10,14H,11-13H2,1-4H3,(H,24,27)(H,25,26)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476229
PNG
(US10874634, Cmpd No. 11)
Show SMILES CC(C)c1cc(c(cc1S(=O)(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C25H35NO4S/c1-16(2)19-14-20(24(3,4)5)21(25(6,7)8)15-22(19)31(29,30)26-18-11-9-17(10-12-18)13-23(27)28/h9-12,14-16,26H,13H2,1-8H3,(H,27,28)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476238
PNG
(US10874634, Cmpd No. 21)
Show SMILES Cc1ccc(NS(=O)(=O)c2cc(C)c3OC(C)(C)CC(C)(C)c3c2)cc1
Show InChI InChI=1S/C21H27NO3S/c1-14-7-9-16(10-8-14)22-26(23,24)17-11-15(2)19-18(12-17)20(3,4)13-21(5,6)25-19/h7-12,22H,13H2,1-6H3
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476232
PNG
(US10874634, Cmpd No. 14)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H27NO4S/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)28(26,27)23-16-8-6-15(7-9-16)20(24)25/h6-9,12-13,23H,10-11H2,1-5H3,(H,24,25)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476235
PNG
(US10874634, Cmpd No. 17)
Show SMILES CCC(CC)(C(O)=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C26H35NO4S/c1-7-26(8-2,23(28)29)18-9-11-19(12-10-18)27-32(30,31)20-13-14-21-22(17-20)25(5,6)16-15-24(21,3)4/h9-14,17,27H,7-8,15-16H2,1-6H3,(H,28,29)
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n/an/a 3.87E+4n/an/an/an/an/an/a



Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476222
PNG
(US10874634, Cmpd No. 05)
Show SMILES CC1(C)CCOc2ccc(cc12)C(=O)Nc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C20H21NO4/c1-20(2)9-10-25-17-8-5-14(12-16(17)20)19(24)21-15-6-3-13(4-7-15)11-18(22)23/h3-8,12H,9-11H2,1-2H3,(H,21,24)(H,22,23)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476223
PNG
(US10874634, Cmpd No. 06)
Show SMILES CC(C)c1cc2c(cc1C(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H33NO3/c1-16(2)19-14-21-22(26(5,6)12-11-25(21,3)4)15-20(19)24(30)27-18-9-7-17(8-10-18)13-23(28)29/h7-10,14-16H,11-13H2,1-6H3,(H,27,30)(H,28,29)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476181
PNG
(US10874634, Cmpd No. 03)
Show SMILES CN(C(=O)c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C24H29NO3/c1-23(2)12-13-24(3,4)20-15-17(8-11-19(20)23)22(28)25(5)18-9-6-16(7-10-18)14-21(26)27/h6-11,15H,12-14H2,1-5H3,(H,26,27)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476227
PNG
(US10874634, Cmpd No. 09A)
Show SMILES COC(=C)Cc1ccc(NS(=O)(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1F
Show InChI InChI=1S/C24H30FNO3S/c1-16(29-6)13-17-7-8-18(14-22(17)25)26-30(27,28)19-9-10-20-21(15-19)24(4,5)12-11-23(20,2)3/h7-10,14-15,26H,1,11-13H2,2-6H3
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476232
PNG
(US10874634, Cmpd No. 14)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H27NO4S/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)28(26,27)23-16-8-6-15(7-9-16)20(24)25/h6-9,12-13,23H,10-11H2,1-5H3,(H,24,25)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476233
PNG
(US10874634, Cmpd No. 15)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H25NO4S/c1-20(2)11-12-21(3,4)18-13-16(9-10-17(18)20)27(25,26)22-15-7-5-14(6-8-15)19(23)24/h5-10,13,22H,11-12H2,1-4H3,(H,23,24)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476237
PNG
(US10874634, Cmpd No. 19)
Show SMILES CC(C)C(C(O)=O)c1ccc(NS(=O)(=O)c2cc3c(cc2C)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C26H35NO4S/c1-16(2)23(24(28)29)18-8-10-19(11-9-18)27-32(30,31)22-15-21-20(14-17(22)3)25(4,5)12-13-26(21,6)7/h8-11,14-16,23,27H,12-13H2,1-7H3,(H,28,29)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476181
PNG
(US10874634, Cmpd No. 03)
Show SMILES CN(C(=O)c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C24H29NO3/c1-23(2)12-13-24(3,4)20-15-17(8-11-19(20)23)22(28)25(5)18-9-6-16(7-10-18)14-21(26)27/h6-11,15H,12-14H2,1-5H3,(H,26,27)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476231
PNG
(US10874634, Cmpd No. 13)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(cc1)C1(CC1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H31NO4S/c1-16-14-19-20(24(4,5)11-10-23(19,2)3)15-21(16)31(29,30)26-18-8-6-17(7-9-18)25(12-13-25)22(27)28/h6-9,14-15,26H,10-13H2,1-5H3,(H,27,28)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476233
PNG
(US10874634, Cmpd No. 15)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H25NO4S/c1-20(2)11-12-21(3,4)18-13-16(9-10-17(18)20)27(25,26)22-15-7-5-14(6-8-15)19(23)24/h5-10,13,22H,11-12H2,1-4H3,(H,23,24)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476230
PNG
(US10874634, Cmpd No. 12)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(cc1)C(C)(C)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H33NO4S/c1-16-14-19-20(24(4,5)13-12-23(19,2)3)15-21(16)31(29,30)26-18-10-8-17(9-11-18)25(6,7)22(27)28/h8-11,14-15,26H,12-13H2,1-7H3,(H,27,28)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476224
PNG
(US10874634, Cmpd No. 07)
Show SMILES Cc1cc2c(cc1S(=O)(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H29NO4S/c1-15-12-18-19(23(4,5)11-10-22(18,2)3)14-20(15)29(27,28)24-17-8-6-16(7-9-17)13-21(25)26/h6-9,12,14,24H,10-11,13H2,1-5H3,(H,25,26)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome P450 26B1


(Homo sapiens (Human))
BDBM476229
PNG
(US10874634, Cmpd No. 11)
Show SMILES CC(C)c1cc(c(cc1S(=O)(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C25H35NO4S/c1-16(2)19-14-20(24(3,4)5)21(25(6,7)8)15-22(19)31(29,30)26-18-11-9-17(10-12-18)13-23(27)28/h9-12,14-16,26H,13H2,1-8H3,(H,27,28)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
Cytochrome CYP26A1


(Homo sapiens (Human))
BDBM476236
PNG
(US10874634, Cmpd No. 18)
Show SMILES CCC(CC)(C(O)=O)c1ccc(NS(=O)(=O)c2cc3c(cc2C)C(C)(C)CCC3(C)C)cc1
Show InChI InChI=1S/C27H37NO4S/c1-8-27(9-2,24(29)30)19-10-12-20(13-11-19)28-33(31,32)23-17-22-21(16-18(23)3)25(4,5)14-15-26(22,6)7/h10-13,16-17,28H,8-9,14-15H2,1-7H3,(H,29,30)
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Queen''s University at Kingston

US Patent


Assay Description
CYP26A1 or CYP26B1 stably transfected HeLa cells were maintained in Minimum Essential Medium (MEM) containing 10% fetal bovine serum (FBS) and 100 &#...


US Patent US10874634 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%