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Patent code US10875829

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM476341
PNG
(3-(3,4-dichlorophenoxy)azetidine | US10875829, Ref...)
Show SMILES Clc1ccc(OC2CNC2)cc1Cl
Show InChI InChI=1S/C9H9Cl2NO/c10-8-2-1-6(3-9(8)11)13-7-4-12-5-7/h1-3,7,12H,4-5H2
PDB

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UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB

US Patent


Assay Description
IC50 Values for Example 1 and the Reference Compound 3-(3,4-Dichlorophenoxy)Azetidine Hydrochloric Acid Salt Employing Radioligand Binding Assays Usi...


US Patent US10875829 (2020)

More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))
BDBM476341
PNG
(3-(3,4-dichlorophenoxy)azetidine | US10875829, Ref...)
Show SMILES Clc1ccc(OC2CNC2)cc1Cl
Show InChI InChI=1S/C9H9Cl2NO/c10-8-2-1-6(3-9(8)11)13-7-4-12-5-7/h1-3,7,12H,4-5H2
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UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20E+3n/an/an/an/an/an/a



INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB

US Patent


Assay Description
IC50 Values for Example 1 and the Reference Compound 3-(3,4-Dichlorophenoxy)Azetidine Hydrochloric Acid Salt Employing Radioligand Binding Assays Usi...


US Patent US10875829 (2020)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))
BDBM476341
PNG
(3-(3,4-dichlorophenoxy)azetidine | US10875829, Ref...)
Show SMILES Clc1ccc(OC2CNC2)cc1Cl
Show InChI InChI=1S/C9H9Cl2NO/c10-8-2-1-6(3-9(8)11)13-7-4-12-5-7/h1-3,7,12H,4-5H2
NCI pathway
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UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.50E+3n/an/an/an/an/an/a



INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB

US Patent


Assay Description
IC50 Values for Example 1 and the Reference Compound 3-(3,4-Dichlorophenoxy)Azetidine Hydrochloric Acid Salt Employing Radioligand Binding Assays Usi...


US Patent US10875829 (2020)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))
BDBM476340
PNG
(3-(2,3-difluorophenoxy)azetidine | US10875829, Exa...)
Show SMILES Fc1cccc(OC2CNC2)c1F
Show InChI InChI=1S/C9H9F2NO/c10-7-2-1-3-8(9(7)11)13-6-4-12-5-6/h1-3,6,12H,4-5H2
NCI pathway
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UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10E+4n/an/an/an/an/an/a



INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB

US Patent


Assay Description
IC50 Values for Example 1 and the Reference Compound 3-(3,4-Dichlorophenoxy)Azetidine Hydrochloric Acid Salt Employing Radioligand Binding Assays Usi...


US Patent US10875829 (2020)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM476340
PNG
(3-(2,3-difluorophenoxy)azetidine | US10875829, Exa...)
Show SMILES Fc1cccc(OC2CNC2)c1F
Show InChI InChI=1S/C9H9F2NO/c10-7-2-1-3-8(9(7)11)13-6-4-12-5-6/h1-3,6,12H,4-5H2
PDB

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UniProtKB/SwissProt

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antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.40E+4n/an/an/an/an/an/a



INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB

US Patent


Assay Description
IC50 Values for Example 1 and the Reference Compound 3-(3,4-Dichlorophenoxy)Azetidine Hydrochloric Acid Salt Employing Radioligand Binding Assays Usi...


US Patent US10875829 (2020)

More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))
BDBM476340
PNG
(3-(2,3-difluorophenoxy)azetidine | US10875829, Exa...)
Show SMILES Fc1cccc(OC2CNC2)c1F
Show InChI InChI=1S/C9H9F2NO/c10-7-2-1-3-8(9(7)11)13-6-4-12-5-6/h1-3,6,12H,4-5H2
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.90E+4n/an/an/an/an/an/a



INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB

US Patent


Assay Description
IC50 Values for Example 1 and the Reference Compound 3-(3,4-Dichlorophenoxy)Azetidine Hydrochloric Acid Salt Employing Radioligand Binding Assays Usi...


US Patent US10875829 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%