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Patent code US10875832

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
UDP-3-O-acyl-N-acetylglucosamine deacetylase


()
BDBM50200120
PNG
(CHEMBL260091 | CHIR-090 | US10875832, Compound ChI...)
Show SMILES C[C@@H](O)[C@H](NC(=O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1)C(=O)NO
Show InChI InChI=1S/C24H27N3O5/c1-17(28)22(24(30)26-31)25-23(29)21-10-8-19(9-11-21)3-2-18-4-6-20(7-5-18)16-27-12-14-32-15-13-27/h4-11,17,22,28,31H,12-16H2,1H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
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PC cid
PC sid
PDB
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



FORGE THERAPEUTICS, INC.

US Patent


Assay Description
LpxC inhibition assays were performed using liquid chromatography with tandem mass spectrometry. Assays were performed, in duplicate, in opaque, 96-w...


US Patent US10875832 (2020)

More data for this
Ligand-Target Pair
UDP-3-O-acyl-N-acetylglucosamine deacetylase


()
BDBM476343
PNG
(US10875832, Compound 98)
Show SMILES Oc1c(CNc2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Show InChI InChI=1S/C24H24N4O3/c29-23-22(26-17-27-24(23)30)15-25-21-9-7-19(8-10-21)2-1-18-3-5-20(6-4-18)16-28-11-13-31-14-12-28/h3-10,17,25,29H,11-16H2,(H,26,27,30)
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US Patent
n/an/a 55n/an/an/an/an/an/a



FORGE THERAPEUTICS, INC.

US Patent


Assay Description
LpxC inhibition assays were performed using liquid chromatography with tandem mass spectrometry. Assays were performed, in duplicate, in opaque, 96-w...


US Patent US10875832 (2020)

More data for this
Ligand-Target Pair
UDP-3-O-acyl-N-acetylglucosamine deacetylase


()
BDBM476342
PNG
(US10875832, Compound 97)
Show SMILES Oc1c(CNc2ccc(cc2)C#CC#Cc2ccc(cc2)C(=O)N2CCOCC2)nc[nH]c1=O
Show InChI InChI=1S/C26H22N4O4/c31-24-23(28-18-29-25(24)32)17-27-22-11-7-20(8-12-22)4-2-1-3-19-5-9-21(10-6-19)26(33)30-13-15-34-16-14-30/h5-12,18,27,31H,13-17H2,(H,28,29,32)
PDB
MMDB

NCI pathway
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UniProtKB/SwissProt

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PC cid
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US Patent
n/an/a 55n/an/an/an/an/an/a



FORGE THERAPEUTICS, INC.

US Patent


Assay Description
LpxC inhibition assays were performed using liquid chromatography with tandem mass spectrometry. Assays were performed, in duplicate, in opaque, 96-w...


US Patent US10875832 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%