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Patent code US10889555

Compile Data Set for Download or QSAR

Found 279 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human RNR


(Homo sapiens (Human))
BDBM477482
PNG
(5-bromo-2-(N-((1S,2R)-2-(6-fluoro-2,3-dimethylphen...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ncc(Br)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477358
PNG
(6-(8-oxa-3-azabicyclo[3.2.1]octane-3-carbonyl)-5-c...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c(n1)C(=O)N1CC2CCC(C1)O2)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477418
PNG
(US10889555, Example 200A | US10889555, Example 207...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477305
PNG
(US10889555, Example 39)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1cc(C(=O)N(C)C)c(Cl)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477477
PNG
(US10889555, Example 245)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ncc(Cl)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477447
PNG
(5-fluoro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477445
PNG
(US10889555, Example 222B | US10889555, Example 226...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477519
PNG
(US10889555, Example 287)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)cc1C(N)=S)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477459
PNG
(US10889555, Example 230B)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2[C@H](O)CCOc12)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477520
PNG
(US10889555, Example 288)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2N(C)CCOc12)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477442
PNG
(5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@]2(O)C(F)(F)F)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477484
PNG
(3-chloro-6-(N-((1S,2R)-2-(6-fluoro-2,3-dimethylphe...)
Show SMILES CNC(=O)c1nc(ccc1Cl)S(=O)(=O)N[C@@H]([C@H](C)c1c(F)ccc(C)c1C)c1n[nH]c(=O)o1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477236
PNG
(US10889555, Example 1)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Br)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477414
PNG
(2-(N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1cc(ccc1C(N)=O)C(C)(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477350
PNG
(US10889555, Example 109 | methyl 3-chloro-6-(N-((1...)
Show SMILES COC(=O)c1nc(ccc1Cl)S(=O)(=O)N[C@@H]([C@H](C)c1c(F)ccc(C)c1C)c1n[nH]c(=O)o1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477415
PNG
(5-chloro-2-(N-((1S,2R)-2-(6-fluoro-2,3-dimethylphe...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1cc(c(Cl)cc1C(N)=O)C(C)(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477552
PNG
(US10889555, Example 329)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCCC2(C)N)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477430
PNG
(US10889555, Example 208B)
Show SMILES COc1c(ccc(Cl)c1[C@@H](C)O)S(=O)(=O)N[C@@H]([C@H](C)c1c(F)ccc(C)c1C)c1n[nH]c(=O)o1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477496
PNG
(2-(N-((1S,2R)-2-(3-bromo-6-fluoro-2-methylphenyl)-...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ncc(Cl)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477355
PNG
(5-chloro-N-((1S,2R) 2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c(n1)C(=O)N1CCCC1)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477456
PNG
(N-((1S,2R)-2-(3-chloro-6-fluoro-2-methylphenyl)-1-...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Cl)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477445
PNG
(US10889555, Example 222B | US10889555, Example 226...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477354
PNG
(5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c(n1)C(=O)N1CCOCC1)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477473
PNG
(N-((1S,2R)-2-(3-bromo-6-fluoro-2-methylphenyl)-1-(...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2[C@@H](O)CCOc12)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477465
PNG
(US10889555, Example 235B)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2[C@H](O)CCOc12)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477357
PNG
(6-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-c...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c(n1)C(=O)N1C2CCC1COC2)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477495
PNG
(4-(2,2-difluoroethoxy)-2-(N-((1S,2R)-2-(6-fluoro-2...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1cc(OCC(F)F)ccc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477518
PNG
(US10889555, Example 286)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)cc1C(=O)NO)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477486
PNG
(5-bromo-2-(N-((1S,2R)-2-(3-chloro-6-fluoro-2- | US...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ncc(Br)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(Cl)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477444
PNG
(N-((1S,2R)-2-(3-bromo-6-fluoro-2-methylphenyl)-1-(...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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n/an/a 70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477413
PNG
(US10889555, Example 196)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1cc(c(F)cc1C(N)=O)C(C)(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477425
PNG
(4-chloro-N-((1S,2R)-2-(2-fluoronaphthalene-1-yl)-1...)
Show SMILES COc1c(ccc(Cl)c1C(C)O)S(=O)(=O)N[C@@H]([C@H](C)c1c(F)ccc2ccccc12)c1n[nH]c(=O)o1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477444
PNG
(N-((1S,2R)-2-(3-bromo-6-fluoro-2-methylphenyl)-1-(...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477485
PNG
(3-chloro-6-(N-((1S,2R)-2-(6-fluoro-2,3-dimethylphe...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c(n1)C(=O)N(C)C)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477420
PNG
(US10889555, Example 200B | US10889555, Example 207...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477559
PNG
(US10889555, Example 337)
Show SMILES C[C@@H]([C@H](N(C)S(=O)(=O)c1ccc(Cl)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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antibodypedia
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n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477389
PNG
(8-(N-((1S,2R)-2-(3-bromo-6-fluoro-2-methylphenyl)-...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCCC2(C)OC(C)=O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477269
PNG
(5-chloro-2-(N-((1S,2R)-2-(6-fluoro-2,3-dimethylphe...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC sid
UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477381
PNG
(5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c(n1)C(=O)N1CCC2(COC2)CC1)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477432
PNG
(US10889555, Example 209B | US10889555, Example 228...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Cl)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477464
PNG
(5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2[C@@H](O)CCOc12)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477443
PNG
(US10889555, Example 220B)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@@]2(O)C(F)(F)F)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477493
PNG
(7-(N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1cc2OCCOc2cc1C(N)=O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477453
PNG
(US10889555, Example 227B)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2c1OCC[C@@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477420
PNG
(US10889555, Example 200B | US10889555, Example 207...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477555
PNG
(US10889555, Example 331)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1cc(ccc1C(N)=O)-c1nnco1)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC cid
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UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477564
PNG
(4-cyano-N-(1S,2R)-(6-fluoro-2,3-dimethylphenyl)-1-...)
Show SMILES COc1cc(ccc1S(=O)(=O)N[C@@H]([C@H](C)c1c(F)ccc(C)c1C)c1n[nH]c(=O)o1)C#N
PDB

UniProtKB/SwissProt
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n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477447
PNG
(5-fluoro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2c1OCC[C@]2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477410
PNG
(5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)c(n1)C(C)(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
Human RNR


(Homo sapiens (Human))
BDBM477406
PNG
(US10889555, Example 186)
Show SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c(c1F)C(C)(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
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PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...


US Patent US10889555 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%