Compile Data Set for Download or QSAR
maximum 50k data
Found 52 Enz. Inhib. hit(s) with all data for entry = 9637
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477604((R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  3nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477601(N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  4nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477599(N-[1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-indazo...)
Affinity DataIC50:  5nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477616((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  6nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477618((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  8nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477586(N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  9nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477584(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  9nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477600(N-[1-(3-methylphenyl)-4,5,6,7-tetrahydro-1H-indazo...)
Affinity DataIC50:  9nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477622(Propan-2-yl-3-[(4R)-4-(4,5,6,7-tetrahydro-1,2-benz...)
Affinity DataIC50:  11nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477583(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  11nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477595(4-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  14nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477619((R)—N-(1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrahy...)
Affinity DataIC50:  17nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477598(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  18nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477609(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  25nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477602(Ethyl 3-[4-(4,5,6,7-tetrahydro-1,2-benzoxazole-3-a...)
Affinity DataIC50:  30nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477606(4-chloro-N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  31nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477579(N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazo...)
Affinity DataIC50:  32nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477621(N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  32nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477592(N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,...)
Affinity DataIC50:  32nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477614(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  33nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477607(4-bromo-N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahy...)
Affinity DataIC50:  39nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477612((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  47nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477617(4-fluoro-N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  50nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477594(5-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  66nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477611(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  78nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477603(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  88nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477596(3-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  96nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477597(N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,...)
Affinity DataIC50:  112nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477620(N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  119nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477587(N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  124nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477589(3-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  136nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477574((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  166nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477623(US10889564, Example 53)
Affinity DataIC50:  220nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477576(N-(1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  290nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477590(N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  355nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477613(4-methyl-N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol...)
Affinity DataIC50:  441nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477588(3-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  459nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477585(N-[(4R*)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-...)
Affinity DataIC50:  735nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477591(2-hydroxy-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetra...)
Affinity DataIC50:  881nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477575(N-[1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazo...)
Affinity DataIC50:  1.11E+3nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477610(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  2.00E+3nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477608((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  2.08E+3nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477572(N-(1-(2-Fluorophenyl)-4,5,6,7-tetrahydro-1H-indazo...)
Affinity DataIC50:  2.17E+3nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM62235(MLS-0412040.0001 | N-[1-(2,4-difluorophenyl)-4,5,6...)
Affinity DataIC50:  2.44E+3nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477605(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  2.67E+3nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477615(6-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...)
Affinity DataIC50: >3.00E+3nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477577(N-[1-(3,4-dimethylphenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  5.83E+3nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477573((S)—N-(1-(2-Fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  6.36E+3nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477582(N-[1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  8.20E+3nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477580(Methyl 6-({[1-(3,5-difluorophenyl)-4,5,6,7-tetrahy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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