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Patent code US10889568

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466588
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H25FN4O4/c1-31-20-12-23(26)28-13-18(20)15-7-9-29(10-8-15)24(30)19-11-21(32-2)22(14-27-19)33-17-5-3-16(25)4-6-17/h3-6,11-15H,7-10H2,1-2H3,(H2,26,28)
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n/an/a<27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466594
PNG
((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C
Show InChI InChI=1S/C24H26N4O3/c1-16-12-23(25)27-14-19(16)17-8-10-28(11-9-17)24(29)20-13-21(30-2)22(15-26-20)31-18-6-4-3-5-7-18/h3-7,12-15,17H,8-11H2,1-2H3,(H2,25,27)
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466599
PNG
(US10800757, Compound 15 | US10889568, Compound 15 ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-15-20(19)30-17-5-3-2-4-6-17)22(28)27-11-9-26(10-12-27)16-7-8-21(23)25-14-16/h2-8,13-15H,9-12H2,1H3,(H2,23,25)
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466590
PNG
(US10800757, Compound 6 | US10889568, Compound 6 | ...)
Show SMILES COc1cc(ncc1Oc1ccc(OC(C)C)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C25H29N5O4/c1-16(2)33-18-4-6-19(7-5-18)34-23-15-27-21(14-22(23)32-3)25(31)30-12-10-17(11-13-30)20-8-9-24(26)29-28-20/h4-9,14-17H,10-13H2,1-3H3,(H2,26,29)
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466585
PNG
(US10800757, Compound 1 | US10889568, Compound 1 | ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-22(25)27-13-18(19)28-7-9-29(10-8-28)23(30)17-11-20(32-2)21(14-26-17)33-16-5-3-15(24)4-6-16/h3-6,11-14H,7-10H2,1-2H3,(H2,25,27)
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n/an/a<27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466591
PNG
(US10800757, Compound 7 | US10889568, Compound 7 | ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C
Show InChI InChI=1S/C24H26FN5O4/c1-15-9-23(26)28-11-20(15)29-7-8-30(17(13-29)14-31)24(32)19-10-21(33-2)22(12-27-19)34-18-5-3-16(25)4-6-18/h3-6,9-12,17,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t17-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466593
PNG
(US10800757, Compound 9 | US10889568, Compound 9 | ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H26FN5O4/c1-33-20-12-23(27)29-13-19(20)30-9-10-31(25(15-30)7-8-25)24(32)18-11-21(34-2)22(14-28-18)35-17-5-3-16(26)4-6-17/h3-6,11-14H,7-10,15H2,1-2H3,(H2,27,29)
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466595
PNG
(US10800757, Compound 11 | US10889568, Compound 11 ...)
Show SMILES COc1cc(nnc1N)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C23H24FN5O4/c1-31-19-12-18(26-13-21(19)33-16-5-3-15(24)4-6-16)23(30)29-9-7-14(8-10-29)17-11-20(32-2)22(25)28-27-17/h3-6,11-14H,7-10H2,1-2H3,(H2,25,28)
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466597
PNG
(US10800757, Compound 13 | US10889568, Compound 13 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-14-20(19)31-17-5-2-15(23)3-6-17)22(29)28-10-8-27(9-11-28)16-4-7-21(24)26-13-16/h2-7,12-14H,8-11H2,1H3,(H2,24,26)
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466598
PNG
((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C23H23FN4O3/c1-30-20-12-19(26-14-21(20)31-18-5-3-17(24)4-6-18)23(29)28-10-8-15(9-11-28)16-2-7-22(25)27-13-16/h2-7,12-15H,8-11H2,1H3,(H2,25,27)
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466665
PNG
(US10800757, Compound 80 | US10889568, Compound 80 ...)
Show SMILES COc1cc(ncc1Oc1ccc(OC(F)(F)F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H22F3N5O4/c1-33-19-12-18(22(32)31-10-8-14(9-11-31)17-6-7-21(27)30-29-17)28-13-20(19)34-15-2-4-16(5-3-15)35-23(24,25)26/h2-7,12-14H,8-11H2,1H3,(H2,27,30)
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n/an/a<27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466589
PNG
(US10800757, Compound 5 | US10889568, Compound 5 | ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H25N5O4/c1-30-19-13-22(24)26-14-18(19)27-8-10-28(11-9-27)23(29)17-12-20(31-2)21(15-25-17)32-16-6-4-3-5-7-16/h3-7,12-15H,8-11H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466596
PNG
(US10800757, Compound 12 | US10889568, Compound 12 ...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(CC2)c2ccc(N)nc2)cc1
Show InChI InChI=1S/C23H25N5O4/c1-30-17-4-6-18(7-5-17)32-21-15-25-19(13-20(21)31-2)23(29)28-11-9-27(10-12-28)16-3-8-22(24)26-14-16/h3-8,13-15H,9-12H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466600
PNG
(US10800757, Compound 16 | US10889568, Compound 16 ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H23N5O3/c1-29-19-13-18(24-14-20(19)30-16-5-3-2-4-6-16)22(28)27-11-9-15(10-12-27)17-7-8-21(23)26-25-17/h2-8,13-15H,9-12H2,1H3,(H2,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466586
PNG
((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1C
Show InChI InChI=1S/C24H25FN4O3/c1-15-11-23(26)28-13-19(15)16-7-9-29(10-8-16)24(30)20-12-21(31-2)22(14-27-20)32-18-5-3-17(25)4-6-18/h3-6,11-14,16H,7-10H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466587
PNG
((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nc1
Show InChI InChI=1S/C23H24N4O3/c1-29-20-13-19(25-15-21(20)30-18-5-3-2-4-6-18)23(28)27-11-9-16(10-12-27)17-7-8-22(24)26-14-17/h2-8,13-16H,9-12H2,1H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466592
PNG
(US10800757, Compound 8 | US10889568, Compound 8 | ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27N5O4/c1-32-20-13-23(26)28-14-19(20)29-10-11-30(25(16-29)8-9-25)24(31)18-12-21(33-2)22(15-27-18)34-17-6-4-3-5-7-17/h3-7,12-15H,8-11,16H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466601
PNG
(US10800757, Compound 17 | US10889568, Compound 17 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-12-18(25-13-20(19)31-16-4-2-15(23)3-5-16)22(29)28-10-8-14(9-11-28)17-6-7-21(24)27-26-17/h2-7,12-14H,8-11H2,1H3,(H2,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466602
PNG
(US10800757, Compound 18 | US10889568, Compound 18 ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C
Show InChI InChI=1S/C24H27N5O4/c1-16-10-23(25)27-12-20(16)28-8-9-29(17(14-28)15-30)24(31)19-11-21(32-2)22(13-26-19)33-18-6-4-3-5-7-18/h3-7,10-13,17,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466603
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCc1ccccc1F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27FN4O4/c1-32-21-12-24(27)29-13-18(21)16-7-9-30(10-8-16)25(31)20-11-22(33-2)23(14-28-20)34-15-17-5-3-4-6-19(17)26/h3-6,11-14,16H,7-10,15H2,1-2H3,(H2,27,29)
PDB

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n/an/a 32n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466604
PNG
(US10800757, Compound 20 | US10800757, Compound 81 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1ccc(N)nc1
Show InChI InChI=1S/C23H24FN5O4/c1-32-20-10-19(26-12-21(20)33-18-5-2-15(24)3-6-18)23(31)29-9-8-28(13-17(29)14-30)16-4-7-22(25)27-11-16/h2-7,10-12,17,30H,8-9,13-14H2,1H3,(H2,25,27)/t17-/m1/s1
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM477646
PNG
(US10889568, Compound 21 | [4-(6-Amino-5-methoxy-py...)
Show SMILES COc1cc(nnc1C)C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H26N4O4/c1-16-21(30-2)13-19(27-26-16)17-9-11-28(12-10-17)24(29)20-14-22(31-3)23(15-25-20)32-18-7-5-4-6-8-18/h4-8,13-15,17H,9-12H2,1-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466606
PNG
((6-Amino-3',4',5',6'-tetrahydro-2'H- [3,4']bipyrid...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2ccc(N)nc2)cc1
Show InChI InChI=1S/C24H26N4O4/c1-30-18-4-6-19(7-5-18)32-22-15-26-20(13-21(22)31-2)24(29)28-11-9-16(10-12-28)17-3-8-23(25)27-14-17/h3-8,13-16H,9-12H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466634
PNG
((1R)-1-[(2R)-4-(6-amino-4- methoxypyridin-3-yl)-1-...)
Show SMILES COc1cc(N)ncc1N1CCN([C@H](C1)[C@@H](C)O)C(=O)c1ccc(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H27N5O4/c1-16(30)21-15-28(20-14-27-23(25)12-22(20)32-2)10-11-29(21)24(31)19-9-8-18(13-26-19)33-17-6-4-3-5-7-17/h3-9,12-14,16,21,30H,10-11,15H2,1-2H3,(H2,25,27)/t16-,21-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466607
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H26N4O4/c1-30-20-13-23(25)27-14-18(20)16-8-10-28(11-9-16)24(29)19-12-21(31-2)22(15-26-19)32-17-6-4-3-5-7-17/h3-7,12-16H,8-11H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466608
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H25F3N4O4/c1-34-20-12-23(29)31-13-18(20)15-7-9-32(10-8-15)24(33)19-11-21(35-2)22(14-30-19)36-17-5-3-16(4-6-17)25(26,27)28/h3-6,11-15H,7-10H2,1-2H3,(H2,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466609
PNG
(US10800757, Compound 25 | US10889568, Compound 25 ...)
Show SMILES COc1cc(ncc1OCC1CCC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-28-18-11-17(23-12-19(18)29-13-14-3-2-4-14)21(27)26-9-7-15(8-10-26)16-5-6-20(22)25-24-16/h5-6,11-12,14-15H,2-4,7-10,13H2,1H3,(H2,22,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466610
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1(C)CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-23(6-7-23)14-31-20-13-25-17(10-19(20)30-3)22(28)27-8-4-15(5-9-27)16-12-26-21(24)11-18(16)29-2/h10-13,15H,4-9,14H2,1-3H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM477706
PNG
(US10889568, Compound 81 | [(R)-4-(6-Amino-pyridin-...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1ccc(N)nc1
Show InChI InChI=1S/C23H25N5O4/c1-31-20-11-19(25-13-21(20)32-18-5-3-2-4-6-18)23(30)28-10-9-27(14-17(28)15-29)16-7-8-22(24)26-12-16/h2-8,11-13,17,29H,9-10,14-15H2,1H3,(H2,24,26)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM477652
PNG
(US10889568, Compound 27 | [(R)-4-(6-Amino-4-methox...)
Show SMILES COC[C@H]1CN(CCN1C(=O)c1cc(OC)c(Oc2ccccc2)cn1)c1cnc(C)cc1OC
Show InChI InChI=1S/C26H30N4O5/c1-18-12-23(33-3)22(14-27-18)29-10-11-30(19(16-29)17-32-2)26(31)21-13-24(34-4)25(15-28-21)35-20-8-6-5-7-9-20/h5-9,12-15,19H,10-11,16-17H2,1-4H3/t19-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466617
PNG
(US10800757, Compound 33 | US10889568, Compound 33 ...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H22F3N5O3/c1-33-19-12-18(28-13-20(19)34-16-4-2-15(3-5-16)23(24,25)26)22(32)31-10-8-14(9-11-31)17-6-7-21(27)30-29-17/h2-7,12-14H,8-11H2,1H3,(H2,27,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466618
PNG
(US10800757, Compound 34 | US10889568, Compound 34 ...)
Show SMILES COc1cc(ncc1Oc1ccc(Cl)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H22ClN5O3/c1-30-19-12-18(25-13-20(19)31-16-4-2-15(23)3-5-16)22(29)28-10-8-14(9-11-28)17-6-7-21(24)27-26-17/h2-7,12-14H,8-11H2,1H3,(H2,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466619
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OC1CCCC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-29-19-12-22(24)26-13-17(19)15-7-9-27(10-8-15)23(28)18-11-20(30-2)21(14-25-18)31-16-5-3-4-6-16/h11-16H,3-10H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466620
PNG
(US10800757, Compound 36 | US10889568, Compound 36 ...)
Show SMILES COc1cc(ncc1OCC(C)C)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C20H27N5O3/c1-13(2)12-28-18-11-22-16(10-17(18)27-3)20(26)25-8-6-14(7-9-25)15-4-5-19(21)24-23-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,21,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466668
PNG
(US10800757, Compound 83 | US10889568, Compound 83 ...)
Show SMILES CCOc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H25N5O3/c1-2-30-20-14-19(25-15-21(20)31-17-6-4-3-5-7-17)23(29)28-12-10-16(11-13-28)18-8-9-22(24)27-26-18/h3-9,14-16H,2,10-13H2,1H3,(H2,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466642
PNG
((1S)-1-[(2R)-4-(6-amino-4- methoxypyridin-3-yl)-1-...)
Show SMILES COc1cc(N)ncc1N1CCN([C@H](C1)[C@H](C)O)C(=O)c1ccc(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H27N5O4/c1-16(30)21-15-28(20-14-27-23(25)12-22(20)32-2)10-11-29(21)24(31)19-9-8-18(13-26-19)33-17-6-4-3-5-7-17/h3-9,12-14,16,21,30H,10-11,15H2,1-2H3,(H2,25,27)/t16-,21+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466612
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2cnc(N)cc2OC)cc1
Show InChI InChI=1S/C25H28N4O5/c1-31-17-4-6-18(7-5-17)34-23-15-27-20(12-22(23)33-3)25(30)29-10-8-16(9-11-29)19-14-28-24(26)13-21(19)32-2/h4-7,12-16H,8-11H2,1-3H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466614
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OC1CCCCC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H32N4O4/c1-30-20-13-23(25)27-14-18(20)16-8-10-28(11-9-16)24(29)19-12-21(31-2)22(15-26-19)32-17-6-4-3-5-7-17/h12-17H,3-11H2,1-2H3,(H2,25,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466613
PNG
(6-{-[5-(4-Fluorophenoxy)-4-methoxypyridine-2-carbo...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C23H24FN5O3/c1-14-11-21(25)27-28-22(14)15-7-9-29(10-8-15)23(30)18-12-19(31-2)20(13-26-18)32-17-5-3-16(24)4-6-17/h3-6,11-13,15H,7-10H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466615
PNG
(6-[1-(4-Methoxy-5-phenoxypyridine-2-carbonyl)piper...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C23H25N5O3/c1-15-12-21(24)26-27-22(15)16-8-10-28(11-9-16)23(29)18-13-19(30-2)20(14-25-18)31-17-6-4-3-5-7-17/h3-7,12-14,16H,8-11H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466616
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCc1ccc(F)cc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27FN4O4/c1-32-21-12-24(27)29-13-19(21)17-7-9-30(10-8-17)25(31)20-11-22(33-2)23(14-28-20)34-15-16-3-5-18(26)6-4-16/h3-6,11-14,17H,7-10,15H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466626
PNG
(US10800757, Compound 42 | US10889568, Compound 42 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H26FN5O5/c1-33-20-10-23(26)28-11-19(20)29-7-8-30(16(13-29)14-31)24(32)18-9-21(34-2)22(12-27-18)35-17-5-3-15(25)4-6-17/h3-6,9-12,16,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466628
PNG
(US10800757, Compound 44 | US10889568, Compound 44 ...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2ccc(N)nn2)cc1
Show InChI InChI=1S/C23H25N5O4/c1-30-16-3-5-17(6-4-16)32-21-14-25-19(13-20(21)31-2)23(29)28-11-9-15(10-12-28)18-7-8-22(24)27-26-18/h3-8,13-15H,9-12H2,1-2H3,(H2,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466627
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H28N4O4/c1-31-21-13-24(26)28-14-19(21)18-8-10-29(11-9-18)25(30)20-12-22(32-2)23(15-27-20)33-16-17-6-4-3-5-7-17/h3-7,12-15,18H,8-11,16H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466629
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1CC(F)(F)C1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H28F2N4O4/c1-31-18-8-21(26)28-11-16(18)15-3-5-29(6-4-15)22(30)17-7-19(32-2)20(12-27-17)33-13-14-9-23(24,25)10-14/h7-8,11-12,14-15H,3-6,9-10,13H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466630
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES CCCOc1cnc(cc1OC)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C21H28N4O4/c1-4-9-29-19-13-23-16(10-18(19)28-3)21(26)25-7-5-14(6-8-25)15-12-24-20(22)11-17(15)27-2/h10-14H,4-9H2,1-3H3,(H2,22,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466621
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H28N4O4/c1-28-18-10-21(23)25-11-16(18)15-5-7-26(8-6-15)22(27)17-9-19(29-2)20(12-24-17)30-13-14-3-4-14/h9-12,14-15H,3-8,13H2,1-2H3,(H2,23,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466622
PNG
(US10800757, Compound 38 | US10889568, Compound 38 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1C2CCC1CN(C2)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H26FN5O4/c1-33-21-10-24(27)29-11-20(21)30-13-16-5-6-17(14-30)31(16)25(32)19-9-22(34-2)23(12-28-19)35-18-7-3-15(26)4-8-18/h3-4,7-12,16-17H,5-6,13-14H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466624
PNG
(US10800757, Compound 40 | US10889568, Compound 40 ...)
Show SMILES COc1cc(ncc1Oc1ccc(OC2CC2)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C25H27N5O4/c1-32-22-14-21(25(31)30-12-10-16(11-13-30)20-8-9-24(26)29-28-20)27-15-23(22)34-19-6-4-18(5-7-19)33-17-2-3-17/h4-9,14-17H,2-3,10-13H2,1H3,(H2,26,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466623
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC(C)C)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H30N4O4/c1-14(2)13-30-20-12-24-17(9-19(20)29-4)22(27)26-7-5-15(6-8-26)16-11-25-21(23)10-18(16)28-3/h9-12,14-15H,5-8,13H2,1-4H3,(H2,23,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466625
PNG
(US10800757, Compound 41 | US10889568, Compound 41 ...)
Show SMILES COc1cc(ncc1OCc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H24FN5O3/c1-31-20-12-19(26-13-21(20)32-14-15-2-4-17(24)5-3-15)23(30)29-10-8-16(9-11-29)18-6-7-22(25)28-27-18/h2-7,12-13,16H,8-11,14H2,1H3,(H2,25,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466667
PNG
(US10800757, Compound 82 | US10889568, Compound 82 ...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCN(C[C@@H]2CO)c2ccc(N)nc2)cc1
Show InChI InChI=1S/C24H27N5O5/c1-32-18-4-6-19(7-5-18)34-22-13-26-20(11-21(22)33-2)24(31)29-10-9-28(14-17(29)15-30)16-3-8-23(25)27-12-16/h3-8,11-13,17,30H,9-10,14-15H2,1-2H3,(H2,25,27)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466636
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCCc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C26H30N4O4/c1-32-22-15-25(27)29-16-20(22)19-8-11-30(12-9-19)26(31)21-14-23(33-2)24(17-28-21)34-13-10-18-6-4-3-5-7-18/h3-7,14-17,19H,8-13H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466637
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1CCC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-29-19-11-22(24)26-12-17(19)16-6-8-27(9-7-16)23(28)18-10-20(30-2)21(13-25-18)31-14-15-4-3-5-15/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466638
PNG
(US10800757, Compound 54 | US10889568, Compound 54 ...)
Show SMILES COc1cc(ncc1Oc1ccc(OC(F)F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H23F2N5O4/c1-32-19-12-18(27-13-20(19)33-15-2-4-16(5-3-15)34-23(24)25)22(31)30-10-8-14(9-11-30)17-6-7-21(26)29-28-17/h2-7,12-14,23H,8-11H2,1H3,(H2,26,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM477672
PNG
(US10889568, Compound 47 | [4-(6-Amino-4-methoxy-py...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1nnc(C)cc1OC
Show InChI InChI=1S/C24H26N4O4/c1-16-13-21(31-3)23(27-26-16)17-9-11-28(12-10-17)24(29)19-14-20(30-2)22(15-25-19)32-18-7-5-4-6-8-18/h4-8,13-15,17H,9-12H2,1-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466639
PNG
(US10800757, Compound 55 | US10889568, Compound 55 ...)
Show SMILES COC[C@H]1CN(CCN1C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H28FN5O5/c1-33-15-17-14-30(20-12-29-24(27)11-21(20)34-2)8-9-31(17)25(32)19-10-22(35-3)23(13-28-19)36-18-6-4-16(26)5-7-18/h4-7,10-13,17H,8-9,14-15H2,1-3H3,(H2,27,29)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466632
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCCC1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-29-19-12-22(24)26-13-17(19)16-5-8-27(9-6-16)23(28)18-11-20(30-2)21(14-25-18)31-10-7-15-3-4-15/h11-16H,3-10H2,1-2H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466633
PNG
(US10800757, Compound 49 | US10889568, Compound 49 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1nnc(N)cc1OC
Show InChI InChI=1S/C23H24FN5O4/c1-31-18-11-17(26-13-20(18)33-16-5-3-15(24)4-6-16)23(30)29-9-7-14(8-10-29)22-19(32-2)12-21(25)27-28-22/h3-6,11-14H,7-10H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466640
PNG
(US10800757, Compound 56 | US10889568, Compound 56 ...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1nnc(N)cc1OC
Show InChI InChI=1S/C24H24F3N5O4/c1-34-18-11-17(29-13-20(18)36-16-5-3-15(4-6-16)24(25,26)27)23(33)32-9-7-14(8-10-32)22-19(35-2)12-21(28)30-31-22/h3-6,11-14H,7-10H2,1-2H3,(H2,28,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466635
PNG
(US10800757, Compound 51 | US10889568, Compound 51 ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1C2CCC1CN(C2)c1cnc(N)cc1OC
Show InChI InChI=1S/C25H27N5O4/c1-32-21-11-24(26)28-12-20(21)29-14-16-8-9-17(15-29)30(16)25(31)19-10-22(33-2)23(13-27-19)34-18-6-4-3-5-7-18/h3-7,10-13,16-17H,8-9,14-15H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466641
PNG
(US10800757, Compound 57 | US10889568, Compound 57 ...)
Show SMILES COc1cc(ncc1OCc1ccccc1F)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H24FN5O3/c1-31-20-12-19(26-13-21(20)32-14-16-4-2-3-5-17(16)24)23(30)29-10-8-15(9-11-29)18-6-7-22(25)28-27-18/h2-7,12-13,15H,8-11,14H2,1H3,(H2,25,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466669
PNG
((6-Amino-4-cyclopropoxy-3',4',5',6'- tetrahydro-2'...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC1CC1
Show InChI InChI=1S/C26H28N4O4/c1-32-23-13-21(28-16-24(23)34-18-5-3-2-4-6-18)26(31)30-11-9-17(10-12-30)20-15-29-25(27)14-22(20)33-19-7-8-19/h2-6,13-17,19H,7-12H2,1H3,(H2,27,29)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466670
PNG
(US10800757, Compound 85 | US10889568, Compound 85 ...)
Show SMILES CCOc1cc(N)nnc1C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1
Show InChI InChI=1S/C24H27N5O4/c1-3-32-20-14-22(25)27-28-23(20)16-9-11-29(12-10-16)24(30)18-13-19(31-2)21(15-26-18)33-17-7-5-4-6-8-17/h4-8,13-16H,3,9-12H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466643
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC(C)(C)C)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H32N4O4/c1-23(2,3)14-31-20-13-25-17(10-19(20)30-5)22(28)27-8-6-15(7-9-27)16-12-26-21(24)11-18(16)29-4/h10-13,15H,6-9,14H2,1-5H3,(H2,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466679
PNG
(US10800757, Compound 94a | US10800757, Compound 94...)
Show SMILES COc1cc(ncc1OCC(C)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H27F3N4O4/c1-13(22(23,24)25)12-33-19-11-27-16(8-18(19)32-3)21(30)29-6-4-14(5-7-29)15-10-28-20(26)9-17(15)31-2/h8-11,13-14H,4-7,12H2,1-3H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466671
PNG
((6-Amino-4-propoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES CCCOc1cc(N)ncc1C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccccc2)cn1
Show InChI InChI=1S/C26H30N4O4/c1-3-13-33-22-15-25(27)29-16-20(22)18-9-11-30(12-10-18)26(31)21-14-23(32-2)24(17-28-21)34-19-7-5-4-6-8-19/h4-8,14-18H,3,9-13H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466679
PNG
(US10800757, Compound 94a | US10800757, Compound 94...)
Show SMILES COc1cc(ncc1OCC(C)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C22H27F3N4O4/c1-13(22(23,24)25)12-33-19-11-27-16(8-18(19)32-3)21(30)29-6-4-14(5-7-29)15-10-28-20(26)9-17(15)31-2/h8-11,13-14H,4-7,12H2,1-3H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466675
PNG
(6-(1-{4-Methoxy-5-[4- (trifluoromethyl)phenoxy]pyr...)
Show SMILES COc1cc(ncc1Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C24H24F3N5O3/c1-14-11-21(28)30-31-22(14)15-7-9-32(10-8-15)23(33)18-12-19(34-2)20(13-29-18)35-17-5-3-16(4-6-17)24(25,26)27/h3-6,11-13,15H,7-10H2,1-2H3,(H2,28,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466676
PNG
(5-Methoxy-6-(1-{5-[4- (trifluoromethyl)-phenoxy]-p...)
Show SMILES COc1cc(N)nnc1C1CCN(CC1)C(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cn1
Show InChI InChI=1S/C23H22F3N5O3/c1-33-19-12-20(27)29-30-21(19)14-8-10-31(11-9-14)22(32)18-7-6-17(13-28-18)34-16-4-2-15(3-5-16)23(24,25)26/h2-7,12-14H,8-11H2,1H3,(H2,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466644
PNG
(US10800757, Compound 60 | US10889568, Compound 60 ...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2cc(OC)c(N)nn2)cc1
Show InChI InChI=1S/C24H27N5O5/c1-31-16-4-6-17(7-5-16)34-22-14-26-19(13-20(22)32-2)24(30)29-10-8-15(9-11-29)18-12-21(33-3)23(25)28-27-18/h4-7,12-15H,8-11H2,1-3H3,(H2,25,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466681
PNG
(5-(1-{5-[(2,2-Difluorocyclobutyl)- methoxy]-4-meth...)
Show SMILES COc1cc(ncc1OCC1CCC1(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H28F2N4O4/c1-31-18-10-21(26)28-11-16(18)14-4-7-29(8-5-14)22(30)17-9-19(32-2)20(12-27-17)33-13-15-3-6-23(15,24)25/h9-12,14-15H,3-8,13H2,1-2H3,(H2,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466645
PNG
(US10800757, Compound 61 | US10889568, Compound 61 ...)
Show SMILES COc1cc(ncc1OCC1CC1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C21H27N5O4/c1-28-17-10-20(22)24-11-16(17)25-5-7-26(8-6-25)21(27)15-9-18(29-2)19(12-23-15)30-13-14-3-4-14/h9-12,14H,3-8,13H2,1-2H3,(H2,22,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466646
PNG
(US10800757, Compound 62 | US10889568, Compound 62 ...)
Show SMILES COc1cc(ncc1OC1CCCCC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C22H29N5O3/c1-29-19-13-18(24-14-20(19)30-16-5-3-2-4-6-16)22(28)27-11-9-15(10-12-27)17-7-8-21(23)26-25-17/h7-8,13-16H,2-6,9-12H2,1H3,(H2,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466651
PNG
(US10800757, Compound 67 | US10889568, Compound 67 ...)
Show SMILES COc1cc(ncc1OCCC1CC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-28-18-12-17(23-13-19(18)29-11-8-14-2-3-14)21(27)26-9-6-15(7-10-26)16-4-5-20(22)25-24-16/h4-5,12-15H,2-3,6-11H2,1H3,(H2,22,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466678
PNG
(4-Methoxy-5-[1-(4-methoxy-5-{[(cis- 3-(trifluorome...)
Show SMILES COc1cc(ncc1OC[C@H]1C[C@H](C1)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H29F3N4O4/c1-33-19-10-22(28)30-11-17(19)15-3-5-31(6-4-15)23(32)18-9-20(34-2)21(12-29-18)35-13-14-7-16(8-14)24(25,26)27/h9-12,14-16H,3-8,13H2,1-2H3,(H2,28,30)/t14-,16+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466672
PNG
((6-Amino-4-ethoxy-3',4',5',6'- tetrahydro-2'H-[3,4...)
Show SMILES CCOc1cc(N)nnc1C1CCN(CC1)C(=O)c1cc(OC)c(Oc2ccc(cc2)C(F)(F)F)cn1
Show InChI InChI=1S/C25H26F3N5O4/c1-3-36-20-13-22(29)31-32-23(20)15-8-10-33(11-9-15)24(34)18-12-19(35-2)21(14-30-18)37-17-6-4-16(5-7-17)25(26,27)28/h4-7,12-15H,3,8-11H2,1-2H3,(H2,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466653
PNG
(US10800757, Compound 69 | US10889568, Compound 69 ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H27N5O5/c1-32-20-11-23(25)27-12-19(20)28-8-9-29(16(14-28)15-30)24(31)18-10-21(33-2)22(13-26-18)34-17-6-4-3-5-7-17/h3-7,10-13,16,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466652
PNG
(US10800757, Compound 68 | US10889568, Compound 68 ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1C2COCC1CC(C2)c1cnc(N)cc1OC
Show InChI InChI=1S/C26H28N4O5/c1-32-22-11-25(27)29-12-20(22)16-8-17-14-34-15-18(9-16)30(17)26(31)21-10-23(33-2)24(13-28-21)35-19-6-4-3-5-7-19/h3-7,10-13,16-18H,8-9,14-15H2,1-2H3,(H2,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466677
PNG
(4-Methoxy-5-[1-(4-methoxy-5-{[trans- 3-(trifluorom...)
Show SMILES COc1cc(ncc1OC[C@H]1C[C@@H](C1)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H29F3N4O4/c1-33-19-10-22(28)30-11-17(19)15-3-5-31(6-4-15)23(32)18-9-20(34-2)21(12-29-18)35-13-14-7-16(8-14)24(25,26)27/h9-12,14-16H,3-8,13H2,1-2H3,(H2,28,30)/t14-,16-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466654
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1O[C@@H](C)C1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-14(15-4-5-15)31-21-13-25-18(10-20(21)30-3)23(28)27-8-6-16(7-9-27)17-12-26-22(24)11-19(17)29-2/h10-16H,4-9H2,1-3H3,(H2,24,26)/t14-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466647
PNG
(US10800757, Compound 63 | US10889568, Compound 63 ...)
Show SMILES COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(C[C@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H26FN5O5/c1-33-20-10-23(26)28-11-19(20)29-7-8-30(16(13-29)14-31)24(32)18-9-21(34-2)22(12-27-18)35-17-5-3-15(25)4-6-17/h3-6,9-12,16,31H,7-8,13-14H2,1-2H3,(H2,26,28)/t16-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466673
PNG
(US10800757, Compound 88 | US10889568, Compound 88 ...)
Show SMILES CCOc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C23H24FN5O3/c1-2-31-20-13-19(26-14-21(20)32-17-5-3-16(24)4-6-17)23(30)29-11-9-15(10-12-29)18-7-8-22(25)28-27-18/h3-8,13-15H,2,9-12H2,1H3,(H2,25,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466648
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OCC1(CF)CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H29FN4O4/c1-30-18-10-21(25)27-11-16(18)15-3-7-28(8-4-15)22(29)17-9-19(31-2)20(12-26-17)32-14-23(13-24)5-6-23/h9-12,15H,3-8,13-14H2,1-2H3,(H2,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466649
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES CCOc1cnc(cc1OC)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C20H26N4O4/c1-4-28-18-12-22-15(9-17(18)27-3)20(25)24-7-5-13(6-8-24)14-11-23-19(21)10-16(14)26-2/h9-13H,4-8H2,1-3H3,(H2,21,23)
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n/an/a 830n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466650
PNG
(US10800757, Compound 66 | US10889568, Compound 66 ...)
Show SMILES COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2nnc(N)cc2OC)cc1
Show InChI InChI=1S/C24H27N5O5/c1-31-16-4-6-17(7-5-16)34-21-14-26-18(12-19(21)32-2)24(30)29-10-8-15(9-11-29)23-20(33-3)13-22(25)27-28-23/h4-7,12-15H,8-11H2,1-3H3,(H2,25,27)
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n/an/a 840n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466655
PNG
(US10800757, Compound 71 | US10889568, Compound 71 ...)
Show SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@H]1CO)c1cnc(N)cc1OC
Show InChI InChI=1S/C24H27N5O5/c1-32-20-11-23(25)27-12-19(20)28-8-9-29(16(14-28)15-30)24(31)18-10-21(33-2)22(13-26-18)34-17-6-4-3-5-7-17/h3-7,10-13,16,30H,8-9,14-15H2,1-2H3,(H2,25,27)/t16-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466656
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1OC(C)C)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C21H28N4O4/c1-13(2)29-19-12-23-16(9-18(19)28-4)21(26)25-7-5-14(6-8-25)15-11-24-20(22)10-17(15)27-3/h9-14H,5-8H2,1-4H3,(H2,22,24)
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n/an/a 910n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466657
PNG
(US10800757, Compound 73 | US10889568, Compound 73 ...)
Show SMILES COc1cc(ncc1OCCc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C24H27N5O3/c1-31-21-15-20(26-16-22(21)32-14-11-17-5-3-2-4-6-17)24(30)29-12-9-18(10-13-29)19-7-8-23(25)28-27-19/h2-8,15-16,18H,9-14H2,1H3,(H2,25,28)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466658
PNG
(US10800757, Compound 74 | US10889568, Compound 74 ...)
Show SMILES COc1cc(ncc1OCC(C)(C)C)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H29N5O3/c1-21(2,3)13-29-18-12-23-16(11-17(18)28-4)20(27)26-9-7-14(8-10-26)15-5-6-19(22)25-24-15/h5-6,11-12,14H,7-10,13H2,1-4H3,(H2,22,25)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466660
PNG
(US10800757, Compound 75 | US10889568, Compound 75 ...)
Show SMILES COc1cc(ncc1OCC1(C)CC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-21(7-8-21)13-29-18-12-23-16(11-17(18)28-2)20(27)26-9-5-14(6-10-26)15-3-4-19(22)25-24-15/h3-4,11-12,14H,5-10,13H2,1-2H3,(H2,22,25)
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466661
PNG
(US10800757, Compound 76 | US10889568, Compound 76 ...)
Show SMILES CCCOc1cnc(cc1OC)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C19H25N5O3/c1-3-10-27-17-12-21-15(11-16(17)26-2)19(25)24-8-6-13(7-9-24)14-4-5-18(20)23-22-14/h4-5,11-13H,3,6-10H2,1-2H3,(H2,20,23)
PDB

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n/an/a 1.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466674
PNG
(US10800757, Compound 89 | US10889568, Compound 89 ...)
Show SMILES CCOc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1C2CCC1CC(C2)c1ccc(N)nn1
Show InChI InChI=1S/C25H26FN5O3/c1-2-33-22-13-21(28-14-23(22)34-19-7-3-16(26)4-8-19)25(32)31-17-5-6-18(31)12-15(11-17)20-9-10-24(27)30-29-20/h3-4,7-10,13-15,17-18H,2,5-6,11-12H2,1H3,(H2,27,30)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466662
PNG
((6-Amino-4-methoxy-3',4',5',6'- tetrahydro-2'H-[3,...)
Show SMILES COc1cc(ncc1O[C@H](C)C1CC1)C(=O)N1CCC(CC1)c1cnc(N)cc1OC
Show InChI InChI=1S/C23H30N4O4/c1-14(15-4-5-15)31-21-13-25-18(10-20(21)30-3)23(28)27-8-6-16(7-9-27)17-12-26-22(24)11-19(17)29-2/h10-16H,4-9H2,1-3H3,(H2,24,26)/t14-/m1/s1
PDB

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n/an/a 2.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466663
PNG
(US10800757, Compound 78 | US10889568, Compound 78 ...)
Show SMILES COc1cc(ncc1OCC1CC1)C(=O)N1CCC(CC1)c1nnc(N)cc1C
Show InChI InChI=1S/C21H27N5O3/c1-13-9-19(22)24-25-20(13)15-5-7-26(8-6-15)21(27)16-10-17(28-2)18(11-23-16)29-12-14-3-4-14/h9-11,14-15H,3-8,12H2,1-2H3,(H2,22,24)
PDB

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n/an/a 2.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
Short transient receptor potential channel 6


(Homo sapiens (Human))
BDBM466664
PNG
(US10800757, Compound 79 | US10889568, Compound 79 ...)
Show SMILES COc1cc(ncc1O[C@@H](C)C1CC1)C(=O)N1CCC(CC1)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O3/c1-13(14-3-4-14)29-19-12-23-17(11-18(19)28-2)21(27)26-9-7-15(8-10-26)16-5-6-20(22)25-24-16/h5-6,11-15H,3-4,7-10H2,1-2H3,(H2,22,25)/t13-/m0/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...


US Patent US10889568 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%