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Patent code US10889569

Compile Data Set for Download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477630
PNG
(5-(3-(3-(6-Fluorobenzo[b]thiophen-3-yl)azetidin-1-...)
Show SMILES COCc1nnc(N2CC(C2)c2csc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20FN5O2S/c1-28-11-19-24-25-21(27(19)15-4-6-20(29-2)23-8-15)26-9-13(10-26)17-12-30-18-7-14(22)3-5-16(17)18/h3-8,12-13H,9-11H2,1-2H3
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US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477658
PNG
(1-(1-(5-(Ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4...)
Show SMILES CCOCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C23H27FN6O2/c1-3-32-15-21-26-27-23(30(21)18-7-9-22(31-2)25-12-18)28-13-19(14-28)29-10-4-5-16-11-17(24)6-8-20(16)29/h6-9,11-12,19H,3-5,10,13-15H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477653
PNG
(4-(1-(5-((Difluoromethoxy)methyl)-4-(6-methoxypyri...)
Show SMILES COc1ccc(cn1)-n1c(COC(F)F)nnc1N1CC(C1)N1CCOc2cc(F)ccc12
Show InChI InChI=1S/C21H21F3N6O3/c1-31-19-5-3-14(9-25-19)30-18(12-33-20(23)24)26-27-21(30)28-10-15(11-28)29-6-7-32-17-8-13(22)2-4-16(17)29/h2-5,8-9,15,20H,6-7,10-12H2,1H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477638
PNG
(5-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCCc3c(F)cccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H25FN6O2/c1-30-14-20-25-26-22(29(20)15-8-9-21(31-2)24-11-15)27-12-16(13-27)28-10-4-5-17-18(23)6-3-7-19(17)28/h3,6-9,11,16H,4-5,10,12-14H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477654
PNG
(6-Fluoro-1-(1-(4-(6-methoxypyridin-3-yl)-5-(triflu...)
Show SMILES COc1ccc(cn1)-n1c(nnc1C(F)(F)F)N1CC(C1)N1CCCc2cc(F)ccc12
Show InChI InChI=1S/C21H20F4N6O/c1-32-18-7-5-15(10-26-18)31-19(21(23,24)25)27-28-20(31)29-11-16(12-29)30-8-2-3-13-9-14(22)4-6-17(13)30/h4-7,9-10,16H,2-3,8,11-12H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477651
PNG
(Methyl ((5-(3-(6-fluoro-3,4-dihydroquinolin-1(2H)-...)
Show SMILES COC(=O)NCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C23H26FN7O3/c1-33-21-8-6-17(11-25-21)31-20(12-26-23(32)34-2)27-28-22(31)29-13-18(14-29)30-9-3-4-15-10-16(24)5-7-19(15)30/h5-8,10-11,18H,3-4,9,12-14H2,1-2H3,(H,26,32)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477626
PNG
(3-Chloro-1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridi...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(Cl)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20ClFN6O2/c1-30-12-19-25-26-21(29(19)14-4-6-20(31-2)24-8-14)27-9-15(10-27)28-11-17(22)16-7-13(23)3-5-18(16)28/h3-8,11,15H,9-10,12H2,1-2H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477633
PNG
(5-(3-(3-(6-Fluorobenzofuran-3-yl)azetidin-1-yl)-5-...)
Show SMILES COCc1nnc(N2CC(C2)c2coc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20FN5O3/c1-28-12-19-24-25-21(27(19)15-4-6-20(29-2)23-8-15)26-9-13(10-26)17-11-30-18-7-14(22)3-5-16(17)18/h3-8,11,13H,9-10,12H2,1-2H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477644
PNG
(1-(1-(4-(Benzo[d][1,3]dioxolan-5-yl)-5-(methoxymet...)
Show SMILES COCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc2OCOc2c1
Show InChI InChI=1S/C23H24FN5O3/c1-30-13-22-25-26-23(29(22)17-5-7-20-21(10-17)32-14-31-20)27-11-18(12-27)28-8-2-3-15-9-16(24)4-6-19(15)28/h4-7,9-10,18H,2-3,8,11-14H2,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477640
PNG
(5-(3-(3-(7-Fluorobenzodihydropyran-4-yl)azetidin-1...)
Show SMILES COCc1nnc(N2CC(C2)C2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H24FN5O3/c1-29-13-20-25-26-22(28(20)16-4-6-21(30-2)24-10-16)27-11-14(12-27)17-7-8-31-19-9-15(23)3-5-18(17)19/h3-6,9-10,14,17H,7-8,11-13H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477639
PNG
(5-Fluoro-1-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)N1CCCc2c(F)cccc12
Show InChI InChI=1S/C21H23FN6O/c1-14-24-25-21(28(14)15-8-9-20(29-2)23-11-15)26-12-16(13-26)27-10-4-5-17-18(22)6-3-7-19(17)27/h3,6-9,11,16H,4-5,10,12-13H2,1-2H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477648
PNG
(4-(1-(5-(Ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4...)
Show SMILES CCOCc1nnc(N2CC(C2)N2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H25FN6O3/c1-3-31-14-20-25-26-22(29(20)16-5-7-21(30-2)24-11-16)27-12-17(13-27)28-8-9-32-19-10-15(23)4-6-18(19)28/h4-7,10-11,17H,3,8-9,12-14H2,1-2H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477636
PNG
(5-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(C)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H23FN6O2/c1-14-10-28(19-6-4-15(23)8-18(14)19)17-11-27(12-17)22-26-25-20(13-30-2)29(22)16-5-7-21(31-3)24-9-16/h4-10,17H,11-13H2,1-3H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477624
PNG
(5-(3-(3-(6-Fluoronaphthalen-1-yl)azetidin-1-yl)-5-...)
Show SMILES COCc1nnc(N2CC(C2)c2cccc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C23H22FN5O2/c1-30-14-21-26-27-23(29(21)18-7-9-22(31-2)25-11-18)28-12-16(13-28)19-5-3-4-15-10-17(24)6-8-20(15)19/h3-11,16H,12-14H2,1-2H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477656
PNG
(6-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCC(C)(C)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C24H29FN6O2/c1-24(2)9-10-30(20-7-5-16(25)11-19(20)24)18-13-29(14-18)23-28-27-21(15-32-3)31(23)17-6-8-22(33-4)26-12-17/h5-8,11-12,18H,9-10,13-15H2,1-4H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477627
PNG
(5-Fluoro-1-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)n1cc(C)c2cc(F)ccc12
Show InChI InChI=1S/C21H21FN6O/c1-13-10-27(19-6-4-15(22)8-18(13)19)17-11-26(12-17)21-25-24-14(2)28(21)16-5-7-20(29-3)23-9-16/h4-10,17H,11-12H2,1-3H3
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n/an/a 4.70E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477624
PNG
(5-(3-(3-(6-Fluoronaphthalen-1-yl)azetidin-1-yl)-5-...)
Show SMILES COCc1nnc(N2CC(C2)c2cccc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C23H22FN5O2/c1-30-14-21-26-27-23(29(21)18-7-9-22(31-2)25-11-18)28-12-16(13-28)19-5-3-4-15-10-17(24)6-8-20(15)19/h3-11,16H,12-14H2,1-2H3
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n/an/a 4.90E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477626
PNG
(3-Chloro-1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridi...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(Cl)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20ClFN6O2/c1-30-12-19-25-26-21(29(19)14-4-6-20(31-2)24-8-14)27-9-15(10-27)28-11-17(22)16-7-13(23)3-5-18(16)28/h3-8,11,15H,9-10,12H2,1-2H3
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n/an/a 5.70E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477648
PNG
(4-(1-(5-(Ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4...)
Show SMILES CCOCc1nnc(N2CC(C2)N2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H25FN6O3/c1-3-31-14-20-25-26-22(29(20)16-5-7-21(30-2)24-11-16)27-12-17(13-27)28-8-9-32-19-10-15(23)4-6-18(19)28/h4-7,10-11,17H,3,8-9,12-14H2,1-2H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477645
PNG
(6-Fluoro-1-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)N1CCCc2cc(F)ccc12
Show InChI InChI=1S/C21H23FN6O/c1-14-24-25-21(28(14)17-6-8-20(29-2)23-11-17)26-12-18(13-26)27-9-3-4-15-10-16(22)5-7-19(15)27/h5-8,10-11,18H,3-4,9,12-13H2,1-2H3
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n/an/a 6.20E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477647
PNG
(6-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H25FN6O2/c1-30-14-20-25-26-22(29(20)17-6-8-21(31-2)24-11-17)27-12-18(13-27)28-9-3-4-15-10-16(23)5-7-19(15)28/h5-8,10-11,18H,3-4,9,12-14H2,1-2H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477629
PNG
(5-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(c3cc(F)ccc23)C(F)(F)F)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H20F4N6O2/c1-33-12-19-28-29-21(32(19)14-4-6-20(34-2)27-8-14)30-9-15(10-30)31-11-17(22(24,25)26)16-7-13(23)3-5-18(16)31/h3-8,11,15H,9-10,12H2,1-2H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477625
PNG
(1-(1-(4-(Benzo[d][1,3]dioxolan-5-yl)-5-(methoxymet...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(Cl)c3cc(F)ccc23)n1-c1ccc2OCOc2c1
Show InChI InChI=1S/C22H19ClFN5O3/c1-30-11-21-25-26-22(29(21)14-3-5-19-20(7-14)32-12-31-19)27-8-15(9-27)28-10-17(23)16-6-13(24)2-4-18(16)28/h2-7,10,15H,8-9,11-12H2,1H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477641
PNG
(8-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCOc3c(F)cccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H23FN6O3/c1-29-13-18-24-25-21(28(18)14-6-7-19(30-2)23-10-14)26-11-15(12-26)27-8-9-31-20-16(22)4-3-5-17(20)27/h3-7,10,15H,8-9,11-13H2,1-2H3
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n/an/a 7.50E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477657
PNG
(7-Fluoro-4-(1-(4-(6-methoxypyridin-3-yl)-5-(triflu...)
Show SMILES COc1ccc(cn1)-n1c(nnc1C(F)(F)F)N1CC(C1)N1CCOc2cc(F)ccc12
Show InChI InChI=1S/C20H18F4N6O2/c1-31-17-5-3-13(9-25-17)30-18(20(22,23)24)26-27-19(30)28-10-14(11-28)29-6-7-32-16-8-12(21)2-4-15(16)29/h2-5,8-9,14H,6-7,10-11H2,1H3
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n/an/a 7.90E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477647
PNG
(6-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H25FN6O2/c1-30-14-20-25-26-22(29(20)17-6-8-21(31-2)24-11-17)27-12-18(13-27)28-9-3-4-15-10-16(23)5-7-19(15)28/h5-8,10-11,18H,3-4,9,12-14H2,1-2H3
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n/an/a 8.50E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477655
PNG
((5-(3-(6-Fluoronaphthalen-1-yl)azetidin-1-yl)-4-(6...)
Show SMILES COc1ccc(cn1)-n1c(CO)nnc1N1CC(C1)[N]1=CC=Cc2cc(F)ccc12
Show InChI InChI=1S/C21H20FN6O2/c1-30-20-7-5-16(10-23-20)28-19(13-29)24-25-21(28)26-11-17(12-26)27-8-2-3-14-9-15(22)4-6-18(14)27/h2-10,17,29H,11-13H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477659
PNG
(1-(1-(4-(Benzo[d][1,3]dioxolan-5-yl)-5-(ethoxymeth...)
Show SMILES CCOCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H26FN5O3/c1-2-31-14-23-26-27-24(30(23)18-6-8-21-22(11-18)33-15-32-21)28-12-19(13-28)29-9-3-4-16-10-17(25)5-7-20(16)29/h5-8,10-11,19H,2-4,9,12-15H2,1H3
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n/an/a 9.10E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477642
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H23FN6O3/c1-29-13-19-24-25-21(28(19)15-4-6-20(30-2)23-10-15)26-11-16(12-26)27-7-8-31-18-9-14(22)3-5-17(18)27/h3-6,9-10,16H,7-8,11-13H2,1-2H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477636
PNG
(5-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(C)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H23FN6O2/c1-14-10-28(19-6-4-15(23)8-18(14)19)17-11-27(12-17)22-26-25-20(13-30-2)29(22)16-5-7-21(31-3)24-9-16/h4-10,17H,11-13H2,1-3H3
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n/an/a 1.09E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477635
PNG
(6-Fluoro-3-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)c2cn(C)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H23FN6O2/c1-27-12-18(17-6-4-15(23)8-19(17)27)14-10-28(11-14)22-26-25-20(13-30-2)29(22)16-5-7-21(31-3)24-9-16/h4-9,12,14H,10-11,13H2,1-3H3
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n/an/a 1.09E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477635
PNG
(6-Fluoro-3-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)c2cn(C)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H23FN6O2/c1-27-12-18(17-6-4-15(23)8-19(17)27)14-10-28(11-14)22-26-25-20(13-30-2)29(22)16-5-7-21(31-3)24-9-16/h4-9,12,14H,10-11,13H2,1-3H3
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n/an/a 1.18E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477634
PNG
(5-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(C#N)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H20FN7O2/c1-31-13-20-26-27-22(30(20)16-4-6-21(32-2)25-9-16)28-11-17(12-28)29-10-14(8-24)18-7-15(23)3-5-19(18)29/h3-7,9-10,17H,11-13H2,1-2H3
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n/an/a 1.19E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477645
PNG
(6-Fluoro-1-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)N1CCCc2cc(F)ccc12
Show InChI InChI=1S/C21H23FN6O/c1-14-24-25-21(28(14)17-6-8-20(29-2)23-11-17)26-12-18(13-26)27-9-3-4-15-10-16(22)5-7-19(15)27/h5-8,10-11,18H,3-4,9,12-13H2,1-2H3
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n/an/a 1.21E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477626
PNG
(3-Chloro-1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridi...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(Cl)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20ClFN6O2/c1-30-12-19-25-26-21(29(19)14-4-6-20(31-2)24-8-14)27-9-15(10-27)28-11-17(22)16-7-13(23)3-5-18(16)28/h3-8,11,15H,9-10,12H2,1-2H3
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n/an/a 1.24E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477630
PNG
(5-(3-(3-(6-Fluorobenzo[b]thiophen-3-yl)azetidin-1-...)
Show SMILES COCc1nnc(N2CC(C2)c2csc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20FN5O2S/c1-28-11-19-24-25-21(27(19)15-4-6-20(29-2)23-8-15)26-9-13(10-26)17-12-30-18-7-14(22)3-5-16(17)18/h3-8,12-13H,9-11H2,1-2H3
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n/an/a 1.25E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477659
PNG
(1-(1-(4-(Benzo[d][1,3]dioxolan-5-yl)-5-(ethoxymeth...)
Show SMILES CCOCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H26FN5O3/c1-2-31-14-23-26-27-24(30(23)18-6-8-21-22(11-18)33-15-32-21)28-12-19(13-28)29-9-3-4-16-10-17(25)5-7-20(16)29/h5-8,10-11,19H,2-4,9,12-15H2,1H3
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n/an/a 1.39E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477650
PNG
(4-(1-(5-(Difluoromethyl)-4-(6-methoxypyridin-3-yl)...)
Show SMILES COc1ccc(cn1)-n1c(nnc1N1CC(C1)N1CCOc2cc(F)ccc12)C(F)F
Show InChI InChI=1S/C20H19F3N6O2/c1-30-17-5-3-13(9-24-17)29-19(18(22)23)25-26-20(29)27-10-14(11-27)28-6-7-31-16-8-12(21)2-4-15(16)28/h2-5,8-9,14,18H,6-7,10-11H2,1H3
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n/an/a 1.41E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477640
PNG
(5-(3-(3-(7-Fluorobenzodihydropyran-4-yl)azetidin-1...)
Show SMILES COCc1nnc(N2CC(C2)C2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H24FN5O3/c1-29-13-20-25-26-22(28(20)16-4-6-21(30-2)24-10-16)27-11-14(12-27)17-7-8-31-19-9-15(23)3-5-18(17)19/h3-6,9-10,14,17H,7-8,11-13H2,1-2H3
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n/an/a 1.73E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477581
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)c2ccnc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H21FN6O2/c1-30-13-20-26-27-22(29(20)16-4-6-21(31-2)25-10-16)28-11-14(12-28)17-7-8-24-19-9-15(23)3-5-18(17)19/h3-10,14H,11-13H2,1-2H3
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n/an/a 1.81E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477636
PNG
(5-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(C)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H23FN6O2/c1-14-10-28(19-6-4-15(23)8-18(14)19)17-11-27(12-17)22-26-25-20(13-30-2)29(22)16-5-7-21(31-3)24-9-16/h4-10,17H,11-13H2,1-3H3
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n/an/a 1.98E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477647
PNG
(6-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H25FN6O2/c1-30-14-20-25-26-22(29(20)17-6-8-21(31-2)24-11-17)27-12-18(13-27)28-9-3-4-15-10-16(23)5-7-19(15)28/h5-8,10-11,18H,3-4,9,12-14H2,1-2H3
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n/an/a 2.07E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477626
PNG
(3-Chloro-1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridi...)
Show SMILES COCc1nnc(N2CC(C2)n2cc(Cl)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20ClFN6O2/c1-30-12-19-25-26-21(29(19)14-4-6-20(31-2)24-8-14)27-9-15(10-27)28-11-17(22)16-7-13(23)3-5-18(16)28/h3-8,11,15H,9-10,12H2,1-2H3
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n/an/a 2.07E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477649
PNG
(7-Fluoro-4-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)N1CCOc2cc(F)ccc12
Show InChI InChI=1S/C20H21FN6O2/c1-13-23-24-20(27(13)15-4-6-19(28-2)22-10-15)25-11-16(12-25)26-7-8-29-18-9-14(21)3-5-17(18)26/h3-6,9-10,16H,7-8,11-12H2,1-2H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477633
PNG
(5-(3-(3-(6-Fluorobenzofuran-3-yl)azetidin-1-yl)-5-...)
Show SMILES COCc1nnc(N2CC(C2)c2coc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20FN5O3/c1-28-12-19-24-25-21(27(19)15-4-6-20(29-2)23-8-15)26-9-13(10-26)17-11-30-18-7-14(22)3-5-16(17)18/h3-8,11,13H,9-10,12H2,1-2H3
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n/an/a 2.57E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477635
PNG
(6-Fluoro-3-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)c2cn(C)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H23FN6O2/c1-27-12-18(17-6-4-15(23)8-19(17)27)14-10-28(11-14)22-26-25-20(13-30-2)29(22)16-5-7-21(31-3)24-9-16/h4-9,12,14H,10-11,13H2,1-3H3
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n/an/a 2.58E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477624
PNG
(5-(3-(3-(6-Fluoronaphthalen-1-yl)azetidin-1-yl)-5-...)
Show SMILES COCc1nnc(N2CC(C2)c2cccc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C23H22FN5O2/c1-30-14-21-26-27-23(29(21)18-7-9-22(31-2)25-11-18)28-12-16(13-28)19-5-3-4-15-10-17(24)6-8-20(15)19/h3-11,16H,12-14H2,1-2H3
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n/an/a 2.60E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477640
PNG
(5-(3-(3-(7-Fluorobenzodihydropyran-4-yl)azetidin-1...)
Show SMILES COCc1nnc(N2CC(C2)C2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H24FN5O3/c1-29-13-20-25-26-22(28(20)16-4-6-21(30-2)24-10-16)27-11-14(12-27)17-7-8-31-19-9-15(23)3-5-18(17)19/h3-6,9-10,14,17H,7-8,11-13H2,1-2H3
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n/an/a 3.88E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477630
PNG
(5-(3-(3-(6-Fluorobenzo[b]thiophen-3-yl)azetidin-1-...)
Show SMILES COCc1nnc(N2CC(C2)c2csc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H20FN5O2S/c1-28-11-19-24-25-21(27(19)15-4-6-20(29-2)23-8-15)26-9-13(10-26)17-12-30-18-7-14(22)3-5-16(17)18/h3-8,12-13H,9-11H2,1-2H3
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n/an/a 4.27E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477642
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H23FN6O3/c1-29-13-19-24-25-21(28(19)15-4-6-20(30-2)23-10-15)26-11-16(12-26)27-7-8-31-18-9-14(22)3-5-17(18)27/h3-6,9-10,16H,7-8,11-13H2,1-2H3
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n/an/a 4.41E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477660
PNG
(5-Fluoro-1-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H23FN6O2/c1-29-13-19-24-25-21(28(19)16-4-6-20(30-2)23-10-16)26-11-17(12-26)27-8-7-14-9-15(22)3-5-18(14)27/h3-6,9-10,17H,7-8,11-13H2,1-2H3
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n/an/a 5.20E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477648
PNG
(4-(1-(5-(Ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4...)
Show SMILES CCOCc1nnc(N2CC(C2)N2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H25FN6O3/c1-3-31-14-20-25-26-22(29(20)16-5-7-21(30-2)24-11-16)27-12-17(13-27)28-8-9-32-19-10-15(23)4-6-18(19)28/h4-7,10-11,17H,3,8-9,12-14H2,1-2H3
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n/an/a 5.45E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477637
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2C(=O)COc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H21FN6O4/c1-30-11-18-24-25-21(28(18)14-4-6-19(31-2)23-8-14)26-9-15(10-26)27-16-5-3-13(22)7-17(16)32-12-20(27)29/h3-8,15H,9-12H2,1-2H3
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n/an/a 5.94E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477637
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2C(=O)COc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H21FN6O4/c1-30-11-18-24-25-21(28(18)14-4-6-19(31-2)23-8-14)26-9-15(10-26)27-16-5-3-13(22)7-17(16)32-12-20(27)29/h3-8,15H,9-12H2,1-2H3
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n/an/a 5.95E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM477637
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2C(=O)COc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H21FN6O4/c1-30-11-18-24-25-21(28(18)14-4-6-19(31-2)23-8-14)26-9-15(10-26)27-16-5-3-13(22)7-17(16)32-12-20(27)29/h3-8,15H,9-12H2,1-2H3
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n/an/a 5.95E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1aR: The inhibition effect of the compounds of the present invention on the activity of human V1 aR protein expressed in HEK293/human V1aR stably tr...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477658
PNG
(1-(1-(5-(Ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4...)
Show SMILES CCOCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C23H27FN6O2/c1-3-32-15-21-26-27-23(30(21)18-7-9-22(31-2)25-12-18)28-13-19(14-28)29-10-4-5-16-11-17(24)6-8-20(16)29/h6-9,11-12,19H,3-5,10,13-15H2,1-2H3
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n/an/a 6.10E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477642
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)N2CCOc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C21H23FN6O3/c1-29-13-19-24-25-21(28(19)15-4-6-20(30-2)23-10-15)26-11-16(12-26)27-7-8-31-18-9-14(22)3-5-17(18)27/h3-6,9-10,16H,7-8,11-13H2,1-2H3
PDB

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n/an/a 6.72E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477649
PNG
(7-Fluoro-4-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)N1CCOc2cc(F)ccc12
Show InChI InChI=1S/C20H21FN6O2/c1-13-23-24-20(27(13)15-4-6-19(28-2)22-10-15)25-11-16(12-25)26-7-8-29-18-9-14(21)3-5-17(18)26/h3-6,9-10,16H,7-8,11-12H2,1-2H3
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n/an/a 7.72E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477645
PNG
(6-Fluoro-1-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)N1CCCc2cc(F)ccc12
Show InChI InChI=1S/C21H23FN6O/c1-14-24-25-21(28(14)17-6-8-20(29-2)23-11-17)26-12-18(13-26)27-9-3-4-15-10-16(22)5-7-19(15)27/h5-8,10-11,18H,3-4,9,12-13H2,1-2H3
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n/an/a 9.51E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477581
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)c2ccnc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H21FN6O2/c1-30-13-20-26-27-22(29(20)16-4-6-21(31-2)25-10-16)28-11-14(12-28)17-7-8-24-19-9-15(23)3-5-18(17)19/h3-10,14H,11-13H2,1-2H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Homo sapiens (Human))
BDBM477649
PNG
(7-Fluoro-4-(1-(4-(6-methoxypyridin-3-yl)-5-methyl-...)
Show SMILES COc1ccc(cn1)-n1c(C)nnc1N1CC(C1)N1CCOc2cc(F)ccc12
Show InChI InChI=1S/C20H21FN6O2/c1-13-23-24-20(27(13)15-4-6-19(28-2)22-10-15)25-11-16(12-25)26-7-8-29-18-9-14(21)3-5-17(18)26/h3-6,9-10,16H,7-8,11-12H2,1-2H3
PDB

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US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V2R: The inhibition effect of the compounds of the present invention on the activity of human V2R protein expressed in HEK293/human V2R cells was det...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM477581
PNG
(7-Fluoro-4-(1-(5-(methoxymethyl)-4-(6-methoxypyrid...)
Show SMILES COCc1nnc(N2CC(C2)c2ccnc3cc(F)ccc23)n1-c1ccc(OC)nc1
Show InChI InChI=1S/C22H21FN6O2/c1-30-13-20-26-27-22(29(20)16-4-6-21(31-2)25-10-16)28-11-14(12-28)17-7-8-24-19-9-15(23)3-5-18(17)19/h3-10,14H,11-13H2,1-2H3
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US Patent
n/an/a 4.48E+5n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
V1bR: The inhibition effect of the compounds of the present invention on the activity of human V1bR protein expressed in HEK293/human V1bR cells was ...


US Patent US10889569 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%