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Patent code US10894038

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478095
PNG
(1-((3-(2-Chloro-8-cyanoindolizin-5-yl)pyridin-4-yl...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2cc(Cl)cn12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-8-16-12(9-21)2-3-15(23(16)11-13)14-10-22-7-4-17(14)26-19(18(24)25)5-1-6-19/h2-4,7-8,10-11H,1,5-6H2,(H,24,25)
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n/an/a 26n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478097
PNG
(1-((3-(2-bromo-8-cyanoindolizin-5-yl)pyridin- 4-yl...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2cc(Br)cn12
Show InChI InChI=1S/C19H14BrN3O2S/c20-13-8-16-12(9-21)2-3-15(23(16)11-13)14-10-22-7-4-17(14)26-19(18(24)25)5-1-6-19/h2-4,7-8,10-11H,1,5-6H2,(H,24,25)
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n/an/a 29n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478096
PNG
(2-((3-(2-chloro-8-cyanoindolizin-5-yl)pyridin- 4-y...)
Show SMILES CC(C)(Sc1ccncc1-c1ccc(C#N)c2cc(Cl)cn12)C(O)=O
Show InChI InChI=1S/C18H14ClN3O2S/c1-18(2,17(23)24)25-16-5-6-21-9-13(16)14-4-3-11(8-20)15-7-12(19)10-22(14)15/h3-7,9-10H,1-2H3,(H,23,24)
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n/an/a 30n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478084
PNG
(1-((3-(8-Cyanoindolizin-5-yl)pyridin-4-yl)thio)cyc...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2cccn12
Show InChI InChI=1S/C19H15N3O2S/c20-11-13-4-5-16(22-10-1-3-15(13)22)14-12-21-9-6-17(14)25-19(18(23)24)7-2-8-19/h1,3-6,9-10,12H,2,7-8H2,(H,23,24)
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n/an/a 30n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
Cells were seeded onto 24-well plates at the density of 2.0105 cells per well. The cells were incubated at 37 C., 5% CO2 overnight. After approxima...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478092
PNG
(1-((3-(3-chloro-5-cyanoindolizin-8-yl)pyridin- 4-y...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)n2c(Cl)ccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-17-5-4-15-13(3-2-12(10-21)23(15)17)14-11-22-9-6-16(14)26-19(18(24)25)7-1-8-19/h2-6,9,11H,1,7-8H2,(H,24,25)
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n/an/a 34n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478100
PNG
(1-((3-(8-Cyano-3-fluoroindolizin-5-yl)pyridin-4-yl...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2ccc(F)n12
Show InChI InChI=1S/C19H14FN3O2S/c20-17-5-4-14-12(10-21)2-3-15(23(14)17)13-11-22-9-6-16(13)26-19(18(24)25)7-1-8-19/h2-6,9,11H,1,7-8H2,(H,24,25)
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n/an/a 34n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478089
PNG
(1-((3-(8-cyano-2-(trifluoromethyl)indolizin-5-yl)p...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2cc(cn12)C(F)(F)F
Show InChI InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-8-16-12(9-24)2-3-15(26(16)11-13)14-10-25-7-4-17(14)29-19(18(27)28)5-1-6-19/h2-4,7-8,10-11H,1,5-6H2,(H,27,28)
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n/an/a 44n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
Cells were seeded onto 24-well plates at the density of 2.0105 cells per well. The cells were incubated at 37 C., 5% CO2 overnight. After approxima...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478098
PNG
(1-((3-(2,8-dicyanoindolizin-5-yl)pyridin-4-yl) thi...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2cc(cn12)C#N
Show InChI InChI=1S/C20H14N4O2S/c21-9-13-8-17-14(10-22)2-3-16(24(17)12-13)15-11-23-7-4-18(15)27-20(19(25)26)5-1-6-20/h2-4,7-8,11-12H,1,5-6H2,(H,25,26)
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n/an/a 45n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478091
PNG
(1-((3-(5-cyanoindolizin-8-yl)pyridin-4-yl)thio)cyc...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)n2cccc12
Show InChI InChI=1S/C19H15N3O2S/c20-11-13-4-5-14(16-3-1-10-22(13)16)15-12-21-9-6-17(15)25-19(18(23)24)7-2-8-19/h1,3-6,9-10,12H,2,7-8H2,(H,23,24)
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n/an/a 55n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478085
PNG
(2-((3-(8-cyanoindolizin-5-yl)pyridin-4-yl)thio)-2-...)
Show SMILES CC(C)(Sc1ccncc1-c1ccc(C#N)c2cccn12)C(O)=O
Show InChI InChI=1S/C18H15N3O2S/c1-18(2,17(22)23)24-16-7-8-20-11-13(16)15-6-5-12(10-19)14-4-3-9-21(14)15/h3-9,11H,1-2H3,(H,22,23)
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n/an/a 66n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
Cells were seeded onto 24-well plates at the density of 2.0105 cells per well. The cells were incubated at 37 C., 5% CO2 overnight. After approxima...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478087
PNG
(2-((3-(1-chloro-8-cyanoindolizin-5-yl)pyridin-4-yl...)
Show SMILES CC(C)(Sc1ccncc1-c1ccc(C#N)c2c(Cl)ccn12)C(O)=O
Show InChI InChI=1S/C18H14ClN3O2S/c1-18(2,17(23)24)25-15-5-7-21-10-12(15)14-4-3-11(9-20)16-13(19)6-8-22(14)16/h3-8,10H,1-2H3,(H,23,24)
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n/an/a 68n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
Cells were seeded onto 24-well plates at the density of 2.0105 cells per well. The cells were incubated at 37 C., 5% CO2 overnight. After approxima...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478101
PNG
(1-((3-(8-Cyano-1 fluoroindolizin-5-yl)pyridin-4-yl...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2c(F)ccn12
Show InChI InChI=1S/C19H14FN3O2S/c20-14-5-9-23-15(3-2-12(10-21)17(14)23)13-11-22-8-4-16(13)26-19(18(24)25)6-1-7-19/h2-5,8-9,11H,1,6-7H2,(H,24,25)
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n/an/a 85n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478102
PNG
(1-((3-(3-chloro-8-cyanoindolizin-5-yl)pyridin- 4-y...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2ccc(Cl)n12
Show InChI InChI=1S/C19H14ClN3O2S/c20-17-5-4-14-12(10-21)2-3-15(23(14)17)13-11-22-9-6-16(13)26-19(18(24)25)7-1-8-19/h2-6,9,11H,1,7-8H2,(H,24,25)
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n/an/a 89n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478088
PNG
(1-((3-(8-cyano-2-methylindolizin-5-yl)pyridin-4-yl...)
Show SMILES Cc1cc2c(ccc(-c3cnccc3SC3(CCC3)C(O)=O)n2c1)C#N
Show InChI InChI=1S/C20H17N3O2S/c1-13-9-17-14(10-21)3-4-16(23(17)12-13)15-11-22-8-5-18(15)26-20(19(24)25)6-2-7-20/h3-5,8-9,11-12H,2,6-7H2,1H3,(H,24,25)
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n/an/a 110n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
Cells were seeded onto 24-well plates at the density of 2.0105 cells per well. The cells were incubated at 37 C., 5% CO2 overnight. After approxima...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478094
PNG
(1-((3-(5-cyano-2-fluoroindolizin-8-yl)pyridin-4- y...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)n2cc(F)cc12
Show InChI InChI=1S/C19H14FN3O2S/c20-12-8-16-14(3-2-13(9-21)23(16)11-12)15-10-22-7-4-17(15)26-19(18(24)25)5-1-6-19/h2-4,7-8,10-11H,1,5-6H2,(H,24,25)
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n/an/a 271n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478086
PNG
(2-((3-(3-chloro-8-cyanoindolizin-5-yl)pyridin-4-yl...)
Show SMILES CC(C)(Sc1ccncc1-c1ccc(C#N)c2ccc(Cl)n12)C(O)=O
Show InChI InChI=1S/C18H14ClN3O2S/c1-18(2,17(23)24)25-15-7-8-21-10-12(15)14-4-3-11(9-20)13-5-6-16(19)22(13)14/h3-8,10H,1-2H3,(H,23,24)
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n/an/a 282n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
Cells were seeded onto 24-well plates at the density of 2.0105 cells per well. The cells were incubated at 37 C., 5% CO2 overnight. After approxima...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478099
PNG
(1-((3-(8-cyano-2-(methylsulfonyl)indolizin-5- yl)p...)
Show SMILES CS(=O)(=O)c1cc2c(ccc(-c3cnccc3SC3(CCC3)C(O)=O)n2c1)C#N
Show InChI InChI=1S/C20H17N3O4S2/c1-29(26,27)14-9-17-13(10-21)3-4-16(23(17)12-14)15-11-22-8-5-18(15)28-20(19(24)25)6-2-7-20/h3-5,8-9,11-12H,2,6-7H2,1H3,(H,24,25)
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n/an/a 332n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478092
PNG
(1-((3-(3-chloro-5-cyanoindolizin-8-yl)pyridin- 4-y...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)n2c(Cl)ccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-17-5-4-15-13(3-2-12(10-21)23(15)17)14-11-22-9-6-16(14)26-19(18(24)25)7-1-8-19/h2-6,9,11H,1,7-8H2,(H,24,25)
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n/an/a 424n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478104
PNG
(2-((3-(8-cyanoindolizin-5-yl)pyridin-4-yl)thio)- 3...)
Show SMILES COCC(C)(Sc1ccncc1-c1ccc(C#N)c2cccn12)C(O)=O
Show InChI InChI=1S/C19H17N3O3S/c1-19(12-25-2,18(23)24)26-17-7-8-21-11-14(17)16-6-5-13(10-20)15-4-3-9-22(15)16/h3-9,11H,12H2,1-2H3,(H,23,24)
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n/an/a 504n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM478093
PNG
(1-((3-(2-chloro-5-cyanoindolizin-8-yl)pyridin- 4-y...)
Show SMILES OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)n2cc(Cl)cc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-12-8-16-14(3-2-13(9-21)23(16)11-12)15-10-22-7-4-17(15)26-19(18(24)25)5-1-6-19/h2-4,7-8,10-11H,1,5-6H2,(H,24,25)
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n/an/a 828n/an/an/an/an/an/a



SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.

US Patent


Assay Description
HEK293-URAT1 cell Lines were donated by Japan Fuji Biomedical Research Institute. Negative control cell of HEK293 (MOCK cells) which was transfected ...


US Patent US10894038 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%