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Patent code US10894048

Compile Data Set for Download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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US Patent
n/an/a 0.100n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM478146
PNG
(US10894048, Ex Comp 66)
Show SMILES COC(=O)[C@@H]1C[C@@H](CN1C(=O)C=C)n1nc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C24H24N6O5/c1-5-20(31)29-12-15(10-19(29)24(32)35-4)30-23-21(22(25)26-13-27-23)18(28-30)7-6-14-8-16(33-2)11-17(9-14)34-3/h5,8-9,11,13,15,19H,1,10,12H2,2-4H3,(H2,25,26,27)/t15-,19-/m0/s1
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n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161426
PNG
(US10124003, Ex. Compound 39 | US10894048, Ex Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C23H23N5O3/c1-4-20(29)27-8-7-17(13-27)28-12-16(21-22(24)25-14-26-23(21)28)6-5-15-9-18(30-2)11-19(10-15)31-3/h4,9-12,14,17H,1,7-8,13H2,2-3H3,(H2,24,25,26)/t17-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161419
PNG
(US10124003, Ex. Compound 32 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161434
PNG
(US10894048, Ex Comp 47 | US9108973, 47)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)c2ncnc(N)c12
Show InChI InChI=1S/C26H27N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-/m0/s1
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM478136
PNG
(US10894048, Ex Comp 53)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C26H29N7O3/c1-35-20-12-18(13-21(14-20)36-2)7-8-22-24-25(27)28-17-29-26(24)33(30-22)19-15-32(16-19)23(34)6-5-11-31-9-3-4-10-31/h5-6,12-14,17,19H,3-4,9-11,15-16H2,1-2H3,(H2,27,28,29)/b6-5+
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n/an/a 0.600n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161439
PNG
(US10124003, Ex. Compound 52 | US10894048, Ex Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H28N6O3/c1-29(2)9-5-6-22(32)30-14-19(15-30)31-13-18(23-24(26)27-16-28-25(23)31)8-7-17-10-20(33-3)12-21(11-17)34-4/h5-6,10-13,16,19H,9,14-15H2,1-4H3,(H2,26,27,28)/b6-5+
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n/an/a 0.700n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161450
PNG
(US10124003, Ex. Compound 63 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](O)C2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O4/c1-36-22-10-18(11-23(12-22)37-2)5-6-19-13-33(27-25(19)26(28)29-17-30-27)20-14-32(15-20)24(35)4-3-8-31-9-7-21(34)16-31/h3-4,10-13,17,20-21,34H,7-9,14-16H2,1-2H3,(H2,28,29,30)/b4-3+/t21-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161439
PNG
(US10124003, Ex. Compound 52 | US10894048, Ex Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H28N6O3/c1-29(2)9-5-6-22(32)30-14-19(15-30)31-13-18(23-24(26)27-16-28-25(23)31)8-7-17-10-20(33-3)12-21(11-17)34-4/h5-6,10-13,16,19H,9,14-15H2,1-4H3,(H2,26,27,28)/b6-5+
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n/an/a 1n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161450
PNG
(US10124003, Ex. Compound 63 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](O)C2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O4/c1-36-22-10-18(11-23(12-22)37-2)5-6-19-13-33(27-25(19)26(28)29-17-30-27)20-14-32(15-20)24(35)4-3-8-31-9-7-21(34)16-31/h3-4,10-13,17,20-21,34H,7-9,14-16H2,1-2H3,(H2,28,29,30)/b4-3+/t21-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 1.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM478147
PNG
(US10894048, Ex Comp 68)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CC(N(C2)c2nnco2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N8O4/c1-4-20(33)19-9-15(11-31(19)24-29-28-13-36-24)32-23-21(22(25)26-12-27-23)18(30-32)6-5-14-7-16(34-2)10-17(8-14)35-3/h4,7-8,10,12-13,15,19H,1,9,11H2,2-3H3,(H2,25,26,27)/t15-,19?/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161446
PNG
(US10124003, Ex. Compound 59 | US10835536, Ex. Comp...)
Show SMILES CCN(CC)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H32N6O3/c1-5-31(6-2)11-7-8-24(34)32-16-21(17-32)33-15-20(25-26(28)29-18-30-27(25)33)10-9-19-12-22(35-3)14-23(13-19)36-4/h7-8,12-15,18,21H,5-6,11,16-17H2,1-4H3,(H2,28,29,30)/b8-7+
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n/an/a 1.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 1.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161397
PNG
(US10124003, Ex. Compound 10 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C#CCO)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O4/c1-31-16-8-14(9-17(10-16)32-2)5-6-18-20-21(23)24-13-25-22(20)28(26-18)15-11-27(12-15)19(30)4-3-7-29/h8-10,13,15,29H,7,11-12H2,1-2H3,(H2,23,24,25)
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n/an/a 1.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161444
PNG
(US10124003, Ex. Compound 57 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H30N6O3/c1-17(2)28-9-5-6-23(33)31-14-20(15-31)32-13-19(24-25(27)29-16-30-26(24)32)8-7-18-10-21(34-3)12-22(11-18)35-4/h5-6,10-13,16-17,20,28H,9,14-15H2,1-4H3,(H2,27,29,30)/b6-5+
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n/an/a 1.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161439
PNG
(US10124003, Ex. Compound 52 | US10894048, Ex Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H28N6O3/c1-29(2)9-5-6-22(32)30-14-19(15-30)31-13-18(23-24(26)27-16-28-25(23)31)8-7-17-10-20(33-3)12-21(11-17)34-4/h5-6,10-13,16,19H,9,14-15H2,1-4H3,(H2,26,27,28)/b6-5+
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n/an/a 1.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161447
PNG
(US10124003, Ex. Compound 60 | US10835536, Ex. Comp...)
Show SMILES COCCN(C)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H32N6O4/c1-31(10-11-35-2)9-5-6-24(34)32-16-21(17-32)33-15-20(25-26(28)29-18-30-27(25)33)8-7-19-12-22(36-3)14-23(13-19)37-4/h5-6,12-15,18,21H,9-11,16-17H2,1-4H3,(H2,28,29,30)/b6-5+
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n/an/a 1.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 1.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161434
PNG
(US10894048, Ex Comp 47 | US9108973, 47)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)c2ncnc(N)c12
Show InChI InChI=1S/C26H27N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161399
PNG
(US10124003, Ex. Compound 12 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C24H27N7O3/c1-29(2)9-5-6-21(32)30-13-17(14-30)31-24-22(23(25)26-15-27-24)20(28-31)8-7-16-10-18(33-3)12-19(11-16)34-4/h5-6,10-12,15,17H,9,13-14H2,1-4H3,(H2,25,26,27)/b6-5+
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n/an/a 2.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM478142
PNG
(US10894048, Ex Comp 61)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCC(O)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C27H31N7O4/c1-37-21-12-18(13-22(14-21)38-2)5-6-23-25-26(28)29-17-30-27(25)34(31-23)19-15-33(16-19)24(36)4-3-9-32-10-7-20(35)8-11-32/h3-4,12-14,17,19-20,35H,7-11,15-16H2,1-2H3,(H2,28,29,30)/b4-3+
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n/an/a 2.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161388
PNG
(US10124003, Ex. Compound 1 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)
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n/an/a 2.40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM478137
PNG
(US10894048, Ex Comp 55)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCC2)c2ncnc(N)c12
Show InChI InChI=1S/C25H27N7O3/c1-34-19-11-17(12-20(13-19)35-2)6-7-21-23-24(26)27-16-28-25(23)32(29-21)18-14-31(15-18)22(33)5-3-8-30-9-4-10-30/h3,5,11-13,16,18H,4,8-10,14-15H2,1-2H3,(H2,26,27,28)/b5-3+
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n/an/a 2.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161406
PNG
(US10124003, Ex. Compound 19 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN(C)C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H31N7O3/c1-17(2)31(3)10-6-7-23(34)32-14-19(15-32)33-26-24(25(27)28-16-29-26)22(30-33)9-8-18-11-20(35-4)13-21(12-18)36-5/h6-7,11-13,16-17,19H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+
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n/an/a 2.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM161439
PNG
(US10124003, Ex. Compound 52 | US10894048, Ex Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H28N6O3/c1-29(2)9-5-6-22(32)30-14-19(15-30)31-13-18(23-24(26)27-16-28-25(23)31)8-7-17-10-20(33-3)12-21(11-17)34-4/h5-6,10-13,16,19H,9,14-15H2,1-4H3,(H2,26,27,28)/b6-5+
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n/an/a 2.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161402
PNG
(US10124003, Ex. Compound 15 | US10835536, Ex. Comp...)
Show SMILES CCN(C)C\C=C\C(=O)N1CC(C1)n1nc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H29N7O3/c1-5-30(2)10-6-7-22(33)31-14-18(15-31)32-25-23(24(26)27-16-28-25)21(29-32)9-8-17-11-19(34-3)13-20(12-17)35-4/h6-7,11-13,16,18H,5,10,14-15H2,1-4H3,(H2,26,27,28)/b7-6+
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n/an/a 3n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM161450
PNG
(US10124003, Ex. Compound 63 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](O)C2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O4/c1-36-22-10-18(11-23(12-22)37-2)5-6-19-13-33(27-25(19)26(28)29-17-30-27)20-14-32(15-20)24(35)4-3-8-31-9-7-21(34)16-31/h3-4,10-13,17,20-21,34H,7-9,14-16H2,1-2H3,(H2,28,29,30)/b4-3+/t21-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161427
PNG
(US10124003, Ex. Compound 40 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C28H32N6O3/c1-36-23-14-20(15-24(16-23)37-2)7-8-21-17-34(28-26(21)27(29)30-19-31-28)22-9-13-33(18-22)25(35)6-5-12-32-10-3-4-11-32/h5-6,14-17,19,22H,3-4,9-13,18H2,1-2H3,(H2,29,30,31)/b6-5+/t22-/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 3.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161407
PNG
(US10835536, Ex. Comp 20 | US10894048, Ex Comp 20 |...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C27H31N7O3/c1-36-21-13-19(14-22(15-21)37-2)8-9-23-25-26(28)29-18-30-27(25)34(31-23)20-16-33(17-20)24(35)7-6-12-32-10-4-3-5-11-32/h6-7,13-15,18,20H,3-5,10-12,16-17H2,1-2H3,(H2,28,29,30)/b7-6+
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n/an/a 3.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 3.60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM298362
PNG
(US10124003, Ex. Compound 28 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](CO)N(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O4/c1-4-20(31)28-11-15(9-16(28)12-30)29-23-21(22(24)25-13-26-23)19(27-29)6-5-14-7-17(32-2)10-18(8-14)33-3/h4,7-8,10,13,15-16,30H,1,9,11-12H2,2-3H3,(H2,24,25,26)/t15-,16-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161401
PNG
(US10124003, Ex. Compound 14 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H29N7O3/c1-16(2)27-9-5-6-22(33)31-13-18(14-31)32-25-23(24(26)28-15-29-25)21(30-32)8-7-17-10-19(34-3)12-20(11-17)35-4/h5-6,10-12,15-16,18,27H,9,13-14H2,1-4H3,(H2,26,28,29)/b6-5+
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n/an/a 3.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161403
PNG
(US10835536, Ex. Comp 16 | US10894048, Ex Comp 16 |...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC2CCC2)c2ncnc(N)c12
Show InChI InChI=1S/C26H29N7O3/c1-35-20-11-17(12-21(13-20)36-2)8-9-22-24-25(27)29-16-30-26(24)33(31-22)19-14-32(15-19)23(34)7-4-10-28-18-5-3-6-18/h4,7,11-13,16,18-19,28H,3,5-6,10,14-15H2,1-2H3,(H2,27,29,30)/b7-4+
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n/an/a 3.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161404
PNG
(US10124003, Ex. Compound 17 | US10835536, Ex. Comp...)
Show SMILES CCN(CC)C\C=C\C(=O)N1CC(C1)n1nc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H31N7O3/c1-5-31(6-2)11-7-8-23(34)32-15-19(16-32)33-26-24(25(27)28-17-29-26)22(30-33)10-9-18-12-20(35-3)14-21(13-18)36-4/h7-8,12-14,17,19H,5-6,11,15-16H2,1-4H3,(H2,27,28,29)/b8-7+
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n/an/a 4.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161433
PNG
(US10124003, Ex. Compound 46 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC)c2ncnc(N)c12
Show InChI InChI=1S/C24H23N5O3/c1-4-5-21(30)28-9-8-18(14-28)29-13-17(22-23(25)26-15-27-24(22)29)7-6-16-10-19(31-2)12-20(11-16)32-3/h10-13,15,18H,8-9,14H2,1-3H3,(H2,25,26,27)/t18-/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161405
PNG
(US10124003, Ex. Compound 18 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H31N7O3/c1-26(2,3)30-10-6-7-22(34)32-14-18(15-32)33-25-23(24(27)28-16-29-25)21(31-33)9-8-17-11-19(35-4)13-20(12-17)36-5/h6-7,11-13,16,18,30H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+
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n/an/a 4.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM298365
PNG
(US10124003, Ex. Compound 38 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H30N6O3/c1-30(2)10-5-6-23(33)31-11-9-20(16-31)32-15-19(24-25(27)28-17-29-26(24)32)8-7-18-12-21(34-3)14-22(13-18)35-4/h5-6,12-15,17,20H,9-11,16H2,1-4H3,(H2,27,28,29)/b6-5+/t20-/m0/s1
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n/an/a 4.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 4.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161409
PNG
(US10894048, Ex Comp 22 | US9108973, 22)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CC[C@H](F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C26H28FN7O3/c1-36-20-10-17(11-21(12-20)37-2)5-6-22-24-25(28)29-16-30-26(24)34(31-22)19-14-33(15-19)23(35)4-3-8-32-9-7-18(27)13-32/h3-4,10-12,16,18-19H,7-9,13-15H2,1-2H3,(H2,28,29,30)/b4-3+/t18-/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161437
PNG
(US10124003, Ex. Compound 50 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C29H34N6O3/c1-37-24-15-21(16-25(17-24)38-2)8-9-22-18-35(29-27(22)28(30)31-20-32-29)23-10-14-34(19-23)26(36)7-6-13-33-11-4-3-5-12-33/h6-7,15-18,20,23H,3-5,10-14,19H2,1-2H3,(H2,30,31,32)/b7-6+/t23-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161429
PNG
(US10124003, Ex. Compound 42 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CCC(O)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C29H34N6O4/c1-38-24-14-20(15-25(16-24)39-2)5-6-21-17-35(29-27(21)28(30)31-19-32-29)22-7-13-34(18-22)26(37)4-3-10-33-11-8-23(36)9-12-33/h3-4,14-17,19,22-23,36H,7-13,18H2,1-2H3,(H2,30,31,32)/b4-3+/t22-/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161410
PNG
(US10124003, Ex. Compound 23 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C26H28FN7O3/c1-36-20-10-17(11-21(12-20)37-2)5-6-22-24-25(28)29-16-30-26(24)34(31-22)19-14-33(15-19)23(35)4-3-8-32-9-7-18(27)13-32/h3-4,10-12,16,18-19H,7-9,13-15H2,1-2H3,(H2,28,29,30)/b4-3+/t18-/m1/s1
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n/an/a 6.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161435
PNG
(US10124003, Ex. Compound 49 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CC[C@@H](F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C28H31FN6O3/c1-37-23-12-19(13-24(14-23)38-2)5-6-20-15-35(28-26(20)27(30)31-18-32-28)22-8-11-34(17-22)25(36)4-3-9-33-10-7-21(29)16-33/h3-4,12-15,18,21-22H,7-11,16-17H2,1-2H3,(H2,30,31,32)/b4-3+/t21-,22+/m1/s1
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n/an/a 6.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161395
PNG
(US10124003, Ex. Compound 8 | US10835536, Ex. Comp ...)
Show SMILES CCOc1cc(OCC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H26N6O3/c1-4-21(31)29-10-9-17(14-29)30-24-22(23(25)26-15-27-24)20(28-30)8-7-16-11-18(32-5-2)13-19(12-16)33-6-3/h4,11-13,15,17H,1,5-6,9-10,14H2,2-3H3,(H2,25,26,27)/t17-/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM478132
PNG
(US10894048, Ex Comp 49)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CCC(F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C28H31FN6O3/c1-37-23-12-19(13-24(14-23)38-2)5-6-20-15-35(28-26(20)27(30)31-18-32-28)22-8-11-34(17-22)25(36)4-3-9-33-10-7-21(29)16-33/h3-4,12-15,18,21-22H,7-11,16-17H2,1-2H3,(H2,30,31,32)/b4-3+/t21?,22-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161452
PNG
(US10124003, Ex. Compound 65 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C27H32N6O3/c1-31(2)11-5-6-24(34)32-12-9-21(10-13-32)33-17-20(25-26(28)29-18-30-27(25)33)8-7-19-14-22(35-3)16-23(15-19)36-4/h5-6,14-18,21H,9-13H2,1-4H3,(H2,28,29,30)/b6-5+
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n/an/a 7n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161411
PNG
(US10124003, Ex. Compound 24 | US10835536, Ex. Comp...)
Show SMILES CCOc1cc(OCC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O3/c1-4-20(30)28-12-16(13-28)29-23-21(22(24)25-14-26-23)19(27-29)8-7-15-9-17(31-5-2)11-18(10-15)32-6-3/h4,9-11,14,16H,1,5-6,12-13H2,2-3H3,(H2,24,25,26)
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n/an/a 7.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161451
PNG
(US10124003, Ex. Compound 64 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H25N5O3/c1-4-21(30)28-9-7-18(8-10-28)29-14-17(22-23(25)26-15-27-24(22)29)6-5-16-11-19(31-2)13-20(12-16)32-3/h4,11-15,18H,1,7-10H2,2-3H3,(H2,25,26,27)
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n/an/a 7.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM478148
PNG
(US10894048, Ex Comp 69)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@H](N(C2)c2nnc(C)o2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C25H24N8O4/c1-5-21(34)20-10-16(12-32(20)25-30-29-14(2)37-25)33-24-22(23(26)27-13-28-24)19(31-33)7-6-15-8-17(35-3)11-18(9-15)36-4/h5,8-9,11,13,16,20H,1,10,12H2,2-4H3,(H2,26,27,28)/t16-,20-/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161416
PNG
(US10124003, Ex. Compound 29 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(CC2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-10-15(11-27)12-28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-7-16(30-2)9-17(8-14)31-3/h4,7-9,13,15H,1,10-12H2,2-3H3,(H2,23,24,25)
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n/an/a 9.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161434
PNG
(US10894048, Ex Comp 47 | US9108973, 47)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)c2ncnc(N)c12
Show InChI InChI=1S/C26H27N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161450
PNG
(US10124003, Ex. Compound 63 | US10835536, Ex. Comp...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](O)C2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O4/c1-36-22-10-18(11-23(12-22)37-2)5-6-19-13-33(27-25(19)26(28)29-17-30-27)20-14-32(15-20)24(35)4-3-8-31-9-7-21(34)16-31/h3-4,10-13,17,20-21,34H,7-9,14-16H2,1-2H3,(H2,28,29,30)/b4-3+/t21-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM161434
PNG
(US10894048, Ex Comp 47 | US9108973, 47)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)c2ncnc(N)c12
Show InChI InChI=1S/C26H27N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161439
PNG
(US10124003, Ex. Compound 52 | US10894048, Ex Comp ...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H28N6O3/c1-29(2)9-5-6-22(32)30-14-19(15-30)31-13-18(23-24(26)27-16-28-25(23)31)8-7-17-10-20(33-3)12-21(11-17)34-4/h5-6,10-13,16,19H,9,14-15H2,1-4H3,(H2,26,27,28)/b6-5+
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n/an/a 21n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161465
PNG
(US10124003, Ref. Ex. Compound 6 | US10835536, Ref....)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@@H](C1)n1nc(C#Cc2cccc(NC(C)=O)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H28N8O2/c1-17(34)29-19-7-4-6-18(14-19)9-10-21-23-24(26)27-16-28-25(23)33(30-21)20-11-13-32(15-20)22(35)8-5-12-31(2)3/h4-8,14,16,20H,11-13,15H2,1-3H3,(H,29,34)(H2,26,27,28)/b8-5+/t20-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161462
PNG
(US10835536, Ref. Ex. Comp 3 | US10894048, Ref. Ex ...)
Show SMILES CCC(=O)N1CC[C@@H](C1)n1nc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C22H24N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h9-11,13,15H,4,7-8,12H2,1-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161464
PNG
(US10124003, Ref. Ex. Compound 5 | US10835536, Ref....)
Show SMILES COc1cccc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C24H27N7O2/c1-29(2)12-5-8-21(32)30-13-11-18(15-30)31-24-22(23(25)26-16-27-24)20(28-31)10-9-17-6-4-7-19(14-17)33-3/h4-8,14,16,18H,11-13,15H2,1-3H3,(H2,25,26,27)/b8-5+/t18-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161461
PNG
(US10124003, Ref. Ex. Compound 2 | US10835536, Ref....)
Show SMILES Nc1nccn2c(nc(C#Cc3ccccc3)c12)C1CCC1
Show InChI InChI=1S/C18H16N4/c19-17-16-15(10-9-13-5-2-1-3-6-13)21-18(14-7-4-8-14)22(16)12-11-20-17/h1-3,5-6,11-12,14H,4,7-8H2,(H2,19,20)
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n/an/a 270n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM1774
PNG
(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m0/s1
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n/an/a 280n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161466
PNG
(US10124003, Ref. Ex. Compound 7 | US10835536, Ref....)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@@H](C1)n1nc(C#Cc2cccnc2)c2c(N)ncnc12
Show InChI InChI=1S/C22H24N8O/c1-28(2)11-4-6-19(31)29-12-9-17(14-29)30-22-20(21(23)25-15-26-22)18(27-30)8-7-16-5-3-10-24-13-16/h3-6,10,13,15,17H,9,11-12,14H2,1-2H3,(H2,23,25,26)/b6-4+/t17-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM161463
PNG
(US10124003, Ref. Ex. Compound 4 | US10835536, Ref....)
Show SMILES CC(C)c1cc(cc(c1)C(C)C)C#Cc1nn([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C29H37N7O/c1-19(2)22-14-21(15-23(16-22)20(3)4)9-10-25-27-28(30)31-18-32-29(27)36(33-25)24-11-13-35(17-24)26(37)8-7-12-34(5)6/h7-8,14-16,18-20,24H,11-13,17H2,1-6H3,(H2,30,31,32)/b8-7+/t24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10894048 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%