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Patent code US10894786

Compile Data Set for Download or QSAR
Found 141 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478951
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES C=CC(=O)N1CC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C20H21N5O2/c1-2-20(27)25-8-7-15(12-25)16-6-3-13(11-21-16)9-19(26)22-18-10-17(23-24-18)14-4-5-14/h2-3,6-7,10-11,14H,1,4-5,8-9,12H2,(H2,22,23,24,26)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478281
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478782
PNG
((Isomer-1 of compound-35): 2-(1''-acryloyl-1'',2''...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478952
PNG
((E)-2-(1'-(but-2-enoyl)-1',2',5',6'-tetrahydro-[2,...)
Show SMILES C\C=C\C(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C22H25N5O2/c1-2-4-22(29)27-10-3-5-17(14-27)18-9-6-15(13-23-18)11-21(28)24-20-12-19(25-26-20)16-7-8-16/h2,4-6,9,12-13,16H,3,7-8,10-11,14H2,1H3,(H2,24,25,26,28)/b4-2+
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478960
PNG
(2-(1'-cyano-1',2',3',6'-tetrahydro-[2,4'-bipyridin...)
Show SMILES O=C(Cc1ccc(nc1)C1=CCN(CC1)C#N)Nc1cc([nH]n1)C1CC1
Show InChI InChI=1S/C19H20N6O/c20-12-25-7-5-15(6-8-25)16-4-1-13(11-21-16)9-19(26)22-18-10-17(23-24-18)14-2-3-14/h1,4-5,10-11,14H,2-3,6-9H2,(H2,22,23,24,26)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478947
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES C=CC(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C21H23N5O2/c1-2-21(28)26-9-3-4-16(13-26)17-8-5-14(12-22-17)10-20(27)23-19-11-18(24-25-19)15-6-7-15/h2,4-5,8,11-12,15H,1,3,6-7,9-10,13H2,(H2,23,24,25,27)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478422
PNG
((S)-2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-y...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478485
PNG
((S)-2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-y...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478954
PNG
(2-(1'-(but-2-ynoyl)-1',2',5',6'-tetrahydro-[2,3'-b...)
Show SMILES CC#CC(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C22H23N5O2/c1-2-4-22(29)27-10-3-5-17(14-27)18-9-6-15(13-23-18)11-21(28)24-20-12-19(25-26-20)16-7-8-16/h5-6,9,12-13,16H,3,7-8,10-11,14H2,1H3,(H2,24,25,26,28)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478942
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478959
PNG
(2-(1'-cyano-1',2',5',6'-tetrahydro-[2,3'-bipyridin...)
Show SMILES O=C(Cc1ccc(nc1)C1=CCCN(C1)C#N)Nc1cc([nH]n1)C1CC1
Show InChI InChI=1S/C19H20N6O/c20-12-25-7-1-2-15(11-25)16-6-3-13(10-21-16)8-19(26)22-18-9-17(23-24-18)14-4-5-14/h2-3,6,9-10,14H,1,4-5,7-8,11H2,(H2,22,23,24,26)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478326
PNG
(2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478946
PNG
(2-(6-(1-acryloylpyrrolidin-3-yl)pyridin-3-yl)-N-(5...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478944
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478934
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478944
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478328
PNG
((S)-2-(4-(1-acryloylpiperidin-4-yl)phenyl)-N-(5-cy...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478948
PNG
(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(1'-propioloyl...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C#C[Si](C)(C)C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478942
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478951
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES C=CC(=O)N1CC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C20H21N5O2/c1-2-20(27)25-8-7-15(12-25)16-6-3-13(11-21-16)9-19(26)22-18-10-17(23-24-18)14-4-5-14/h2-3,6-7,10-11,14H,1,4-5,8-9,12H2,(H2,22,23,24,26)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478955
PNG
(N-(5-cyclopropy1-1H-pyrazol-3-yl)-2-(1'-methacrylo...)
Show SMILES CC(=C)C(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C22H25N5O2/c1-14(2)22(29)27-9-3-4-17(13-27)18-8-5-15(12-23-18)10-21(28)24-20-11-19(25-26-20)16-6-7-16/h4-5,8,11-12,16H,1,3,6-7,9-10,13H2,2H3,(H2,24,25,26,28)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478758
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478430
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)OC(C)(C)C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478948
PNG
(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(1'-propioloyl...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C#C[Si](C)(C)C
PDB
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478958
PNG
(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(6-(1-propiolo...)
Show SMILES O=C(Cc1ccc(nc1)C1=CCN(C1)C(=O)C#C)Nc1cc([nH]n1)C1CC1
Show InChI InChI=1S/C20H19N5O2/c1-2-20(27)25-8-7-15(12-25)16-6-3-13(11-21-16)9-19(26)22-18-10-17(23-24-18)14-4-5-14/h1,3,6-7,10-11,14H,4-5,8-9,12H2,(H2,22,23,24,26)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478940
PNG
(2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCCN(C2)C(=O)C=C)c(F)c1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478327
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478350
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN(C)C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478957
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES C=CC(=O)N1CCC(=CC1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C21H23N5O2/c1-2-21(28)26-9-7-16(8-10-26)17-6-3-14(13-22-17)11-20(27)23-19-12-18(24-25-19)15-4-5-15/h2-3,6-7,12-13,15H,1,4-5,8-11H2,(H2,23,24,25,27)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478489
PNG
(N-(4'-(1 ((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCC(CC1)NC(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478950
PNG
(2-(1'-(but-2-ynoyl)-1',2',5',6'-tetrahydro-[2,3'-b...)
Show SMILES CC#CC(=O)N1CCC=C(C1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478491
PNG
(2-(4-(1-acryloyl-2,3,6,7-tetrahydro-1H-azepin-4-yl...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478947
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES C=CC(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C21H23N5O2/c1-2-21(28)26-9-3-4-16(13-26)17-8-5-14(12-22-17)10-20(27)23-19-11-18(24-25-19)15-6-7-15/h2,4-5,8,11-12,15H,1,3,6-7,9-10,13H2,(H2,23,24,25,27)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478949
PNG
(2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-b...)
Show SMILES CC#CC(=O)N1CCC(=CC1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478329
PNG
(2-(6-(1-acryloylpiperidin-4-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478939
PNG
(2-(6-(1-acryloylpiperidin-3-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478782
PNG
((Isomer-1 of compound-35): 2-(1''-acryloyl-1'',2''...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478934
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478944
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478936
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478351
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN1CCOCC1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478954
PNG
(2-(1'-(but-2-ynoyl)-1',2',5',6'-tetrahydro-[2,3'-b...)
Show SMILES CC#CC(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C22H23N5O2/c1-2-4-22(29)27-10-3-5-17(14-27)18-9-6-15(13-23-18)11-21(28)24-20-12-19(25-26-20)16-7-8-16/h5-6,9,12-13,16H,3,7-8,10-11,14H2,1H3,(H2,24,25,26,28)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478957
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES C=CC(=O)N1CCC(=CC1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C21H23N5O2/c1-2-21(28)26-9-7-16(8-10-26)17-6-3-14(13-22-17)11-20(27)23-19-12-18(24-25-19)15-4-5-15/h2-3,6-7,12-13,15H,1,4-5,8-11H2,(H2,23,24,25,27)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478326
PNG
(2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478937
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES CCC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478666
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478956
PNG
(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(1'-propioloyl...)
Show SMILES O=C(Cc1ccc(nc1)C1=CCCN(C1)C(=O)C#C)Nc1cc([nH]n1)C1CC1
Show InChI InChI=1S/C21H21N5O2/c1-2-21(28)26-9-3-4-16(13-26)17-8-5-14(12-22-17)10-20(27)23-19-11-18(24-25-19)15-6-7-15/h1,4-5,8,11-12,15H,3,6-7,9-10,13H2,(H2,23,24,25,27)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478941
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478946
PNG
(2-(6-(1-acryloylpyrrolidin-3-yl)pyridin-3-yl)-N-(5...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCN(C1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478329
PNG
(2-(6-(1-acryloylpiperidin-4-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478485
PNG
((S)-2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-y...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478281
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478330
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CBr
PDB

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n/an/a 72n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478360
PNG
(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCC(CC1)NC(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478326
PNG
(2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478931
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478430
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)OC(C)(C)C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478956
PNG
(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(1'-propioloyl...)
Show SMILES O=C(Cc1ccc(nc1)C1=CCCN(C1)C(=O)C#C)Nc1cc([nH]n1)C1CC1
Show InChI InChI=1S/C21H21N5O2/c1-2-21(28)26-9-3-4-16(13-26)17-8-5-14(12-22-17)10-20(27)23-19-11-18(24-25-19)15-6-7-15/h1,4-5,8,11-12,15H,3,6-7,9-10,13H2,(H2,23,24,25,27)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478940
PNG
(2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCCN(C2)C(=O)C=C)c(F)c1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478937
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES CCC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478952
PNG
((E)-2-(1'-(but-2-enoyl)-1',2',5',6'-tetrahydro-[2,...)
Show SMILES C\C=C\C(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C22H25N5O2/c1-2-4-22(29)27-10-3-5-17(14-27)18-9-6-15(13-23-18)11-21(28)24-20-12-19(25-26-20)16-7-8-16/h2,4-6,9,12-13,16H,3,7-8,10-11,14H2,1H3,(H2,24,25,26,28)/b4-2+
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478354
PNG
(2-(6-(4-acryloylpiperazin-1-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)N1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478354
PNG
(2-(6-(4-acryloylpiperazin-1-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)N1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478936
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478800
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478955
PNG
(N-(5-cyclopropy1-1H-pyrazol-3-yl)-2-(1'-methacrylo...)
Show SMILES CC(=C)C(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C22H25N5O2/c1-14(2)22(29)27-9-3-4-17(13-27)18-8-5-15(12-23-18)10-21(28)24-20-11-19(25-26-20)16-6-7-16/h4-5,8,11-12,16H,1,3,6-7,9-10,13H2,2H3,(H2,24,25,26,28)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478328
PNG
((S)-2-(4-(1-acryloylpiperidin-4-yl)phenyl)-N-(5-cy...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478934
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
PDB
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478782
PNG
((Isomer-1 of compound-35): 2-(1''-acryloyl-1'',2''...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478938
PNG
(2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)ph...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(C1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478941
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478953
PNG
(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(1'-(3-methylb...)
Show SMILES CC(C)=CC(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C23H27N5O2/c1-15(2)10-23(30)28-9-3-4-18(14-28)19-8-5-16(13-24-19)11-22(29)25-21-12-20(26-27-21)17-6-7-17/h4-5,8,10,12-13,17H,3,6-7,9,11,14H2,1-2H3,(H2,25,26,27,29)
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478422
PNG
((S)-2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-y...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(C1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478949
PNG
(2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-b...)
Show SMILES CC#CC(=O)N1CCC(=CC1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478950
PNG
(2-(1'-(but-2-ynoyl)-1',2',5',6'-tetrahydro-[2,3'-b...)
Show SMILES CC#CC(=O)N1CCC=C(C1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478350
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN(C)C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478360
PNG
(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCC(CC1)NC(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478758
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478491
PNG
(2-(4-(1-acryloyl-2,3,6,7-tetrahydro-1H-azepin-4-yl...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478942
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478938
PNG
(2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)ph...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(C1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478939
PNG
(2-(6-(1-acryloylpiperidin-3-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCCN(C1)C(=O)C=C
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n/an/a 354n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478489
PNG
(N-(4'-(1 ((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCC(CC1)NC(=O)C=C
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n/an/a 380n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478893
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
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n/an/a 398n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478940
PNG
(2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCCN(C2)C(=O)C=C)c(F)c1
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n/an/a 440n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478942
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1
PDB

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n/an/a 445n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478800
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C
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n/an/a 506n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478931
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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n/an/a 590n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478350
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN(C)C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478351
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN1CCOCC1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478944
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C
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n/an/a 676n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478782
PNG
((Isomer-1 of compound-35): 2-(1''-acryloyl-1'',2''...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
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n/an/a 686n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478327
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478893
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478942
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478330
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CBr
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478936
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C
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n/an/a 1.01E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478666
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
PDB

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n/an/a 1.02E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478326
PNG
(2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
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n/an/a 1.30E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478326
PNG
(2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
PDB

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n/an/a 1.31E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478949
PNG
(2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-b...)
Show SMILES CC#CC(=O)N1CCC(=CC1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1
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n/an/a 1.69E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478281
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
PDB
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n/an/a 1.71E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478947
PNG
(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Show SMILES C=CC(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C21H23N5O2/c1-2-21(28)26-9-3-4-16(13-26)17-8-5-14(12-22-17)10-20(27)23-19-11-18(24-25-19)15-6-7-15/h2,4-5,8,11-12,15H,1,3,6-7,9-10,13H2,(H2,23,24,25,27)
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n/an/a 1.73E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478354
PNG
(2-(6-(4-acryloylpiperazin-1-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)N1CCN(CC1)C(=O)C=C
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n/an/a 2.09E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478950
PNG
(2-(1'-(but-2-ynoyl)-1',2',5',6'-tetrahydro-[2,3'-b...)
Show SMILES CC#CC(=O)N1CCC=C(C1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1
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n/an/a 2.19E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478485
PNG
((S)-2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-y...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C
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n/an/a 2.29E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478758
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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n/an/a 2.32E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478328
PNG
((S)-2-(4-(1-acryloylpiperidin-4-yl)phenyl)-N-(5-cy...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1CCN(CC1)C(=O)C=C
PDB
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n/an/a 2.83E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478430
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)OC(C)(C)C
PDB
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n/an/a 3.30E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478939
PNG
(2-(6-(1-acryloylpiperidin-3-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCCN(C1)C(=O)C=C
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n/an/a 3.51E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478666
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
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n/an/a 3.65E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478327
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
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n/an/a 5.49E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478942
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1
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n/an/a 5.76E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 13


(Homo sapiens (Human))
BDBM478932
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES C[C@@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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n/an/a 5.81E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478491
PNG
(2-(4-(1-acryloyl-2,3,6,7-tetrahydro-1H-azepin-4-yl...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(CC1)C(=O)C=C
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n/an/a 6.59E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478951
PNG
(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Show SMILES C=CC(=O)N1CC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1
Show InChI InChI=1S/C20H21N5O2/c1-2-20(27)25-8-7-15(12-25)16-6-3-13(11-21-16)9-19(26)22-18-10-17(23-24-18)14-4-5-14/h2-3,6-7,10-11,14H,1,4-5,8-9,12H2,(H2,22,23,24,26)
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n/an/a 7.79E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478931
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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n/an/a 7.96E+3n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478326
PNG
(2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
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n/an/a>1.00E+4n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 7


(Homo sapiens (Human))
BDBM478329
PNG
(2-(6-(1-acryloylpiperidin-4-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCN(CC1)C(=O)C=C
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n/an/a>1.00E+4n/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478350
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN(C)C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478931
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478327
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478485
PNG
((S)-2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-y...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C
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n/an/an/a 63n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478422
PNG
((S)-2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-y...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(C1)C(=O)C=C
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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478360
PNG
(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCC(CC1)NC(=O)C=C
PDB

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n/an/an/a<25n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478328
PNG
((S)-2-(4-(1-acryloylpiperidin-4-yl)phenyl)-N-(5-cy...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1CCN(CC1)C(=O)C=C
PDB

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n/an/an/a<25n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478326
PNG
(2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
PDB

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n/an/an/a<25n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478281
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478893
PNG
(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C
PDB

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n/an/an/a>100n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478491
PNG
(2-(4-(1-acryloyl-2,3,6,7-tetrahydro-1H-azepin-4-yl...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(CC1)C(=O)C=C
PDB

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n/an/an/a 63n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478932
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES C[C@@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478782
PNG
((Isomer-1 of compound-35): 2-(1''-acryloyl-1'',2''...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C
PDB

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n/an/an/a 63n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478489
PNG
(N-(4'-(1 ((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCC(CC1)NC(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478430
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)OC(C)(C)C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478329
PNG
(2-(6-(1-acryloylpiperidin-4-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478351
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN1CCOCC1
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478800
PNG
(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Show SMILES CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478758
PNG
(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C
PDB

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Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478666
PNG
(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Show SMILES C[C@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C
PDB

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PC sid
UniChem
US Patent
n/an/an/a 63n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478354
PNG
(2-(6-(4-acryloylpiperazin-1-yl)pyridin-3-yl)-N-(5-...)
Show SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)N1CCN(CC1)C(=O)C=C
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/a<25n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478330
PNG
((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Show SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CBr
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a<25n/an/an/an/an/a



Aurigene Discovery Technologies Limited

US Patent


Assay Description
Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...


US Patent US10894786 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%