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Patent code US10894788

Compile Data Set for Download or QSAR
Found 199 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478987
PNG
((R)-1-(5-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCc3c2)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C21H22ClN5O3/c1-3-18(28)27-9-6-13-10-14(4-5-17(13)27)20(29)26-8-7-15(12-26)24-21-23-11-16(22)19(25-21)30-2/h3-5,10-11,15H,1,6-9,12H2,2H3,(H,23,24,25)/t15-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479018
PNG
((R)-N-(4-(3-((5- cyclopropylpyrimidin-2- yl)amino)...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C1CC1
Show InChI InChI=1S/C21H23N5O2/c1-2-19(27)24-17-7-5-15(6-8-17)20(28)26-10-9-18(13-26)25-21-22-11-16(12-23-21)14-3-4-14/h2,5-8,11-12,14,18H,1,3-4,9-10,13H2,(H,24,27)(H,22,23,25)/t18-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479022
PNG
((R)-N-(4-(3-((5-chloro-4- (methylamino)pyrimidin-2...)
Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H21ClN6O2/c1-3-16(27)23-13-6-4-12(5-7-13)18(28)26-9-8-14(11-26)24-19-22-10-15(20)17(21-2)25-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,23,27)(H2,21,22,24,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479036
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C19H20BrN5O2/c1-3-17(26)24-16-5-4-13(8-12(16)2)18(27)25-7-6-15(11-25)23-19-21-9-14(20)10-22-19/h3-5,8-10,15H,1,6-7,11H2,2H3,(H,24,26)(H,21,22,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479085
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#C)cc2)nc1
Show InChI InChI=1S/C18H16ClN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h1,3-6,9-10,15H,7-8,11H2,(H,22,25)(H,20,21,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479103
PNG
(N-(4-((R)-3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OC3CCOC3)c2)ncc1Cl
Show InChI InChI=1S/C24H28ClN5O5/c1-3-21(31)28-19-6-5-15(11-20(19)35-17-8-10-33-14-17)23(32)30-9-7-16(13-30)27-24-26-12-18(25)22(29-24)34-4-2/h3,5-6,11-12,16-17H,1,4,7-10,13-14H2,2H3,(H,28,31)(H,26,27,29)/t16-,17?/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479117
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C22H27BrN6O3/c1-4-20(30)27-18-6-5-15(11-19(18)32-10-9-28(2)3)21(31)29-8-7-17(14-29)26-22-24-12-16(23)13-25-22/h4-6,11-13,17H,1,7-10,14H2,2-3H3,(H,27,30)(H,24,25,26)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478990
PNG
((R)-1-(5-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCc3c2)C(=O)C=C)nc1
Show InChI InChI=1S/C20H20ClN5O2/c1-2-18(27)26-8-5-13-9-14(3-4-17(13)26)19(28)25-7-6-16(12-25)24-20-22-10-15(21)11-23-20/h2-4,9-11,16H,1,5-8,12H2,(H,22,23,24)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479038
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCN(C)CC2)ncc1Cl
Show InChI InChI=1S/C24H30ClN7O3/c1-4-21(33)28-19-6-5-16(13-20(19)31-11-9-30(2)10-12-31)23(34)32-8-7-17(15-32)27-24-26-14-18(25)22(29-24)35-3/h4-6,13-14,17H,1,7-12,15H2,2-3H3,(H,28,33)(H,26,27,29)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479046
PNG
((R)-N-(4-(3-((5-chloro-4- (dimethylamino)pyrimidin...)
Show SMILES CN(C)c1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H23ClN6O2/c1-4-17(28)23-14-7-5-13(6-8-14)19(29)27-10-9-15(12-27)24-20-22-11-16(21)18(25-20)26(2)3/h4-8,11,15H,1,9-10,12H2,2-3H3,(H,23,28)(H,22,24,25)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479052
PNG
((R)-N-(4-(3-((5-chloro-4- (trifluoromethyl)pyrimid...)
Show SMILES FC(F)(F)c1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H17ClF3N5O2/c1-2-15(29)25-12-5-3-11(4-6-12)17(30)28-8-7-13(10-28)26-18-24-9-14(20)16(27-18)19(21,22)23/h2-6,9,13H,1,7-8,10H2,(H,25,29)(H,24,26,27)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479055
PNG
((R)-N-(4-(3-((5-chloro-4- phenoxypyrimidin-2- yl)a...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1Oc1ccccc1
Show InChI InChI=1S/C24H22ClN5O3/c1-2-21(31)27-17-10-8-16(9-11-17)23(32)30-13-12-18(15-30)28-24-26-14-20(25)22(29-24)33-19-6-4-3-5-7-19/h2-11,14,18H,1,12-13,15H2,(H,27,31)(H,26,28,29)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479104
PNG
((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OCCN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C23H29ClN6O4/c1-5-20(31)27-18-7-6-15(12-19(18)34-11-10-29(2)3)22(32)30-9-8-16(14-30)26-23-25-13-17(24)21(28-23)33-4/h5-7,12-13,16H,1,8-11,14H2,2-4H3,(H,27,31)(H,25,26,28)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479111
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#CC)cc2)ncc1Cl
Show InChI InChI=1S/C20H20ClN5O3/c1-3-4-17(27)23-14-7-5-13(6-8-14)19(28)26-10-9-15(12-26)24-20-22-11-16(21)18(25-20)29-2/h5-8,11,15H,9-10,12H2,1-2H3,(H,23,27)(H,22,24,25)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478961
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)c(OC)n1
Show InChI InChI=1S/C20H22ClN5O4/c1-4-17(27)24-15-6-5-12(9-16(15)29-2)19(28)26-8-7-13(11-26)23-20-22-10-14(21)18(25-20)30-3/h4-6,9-10,13H,1,7-8,11H2,2-3H3,(H,24,27)(H,22,23,25)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478963
PNG
((R)-1-(6-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCCc3c2)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C22H24ClN5O3/c1-3-19(29)28-9-4-5-14-11-15(6-7-18(14)28)21(30)27-10-8-16(13-27)25-22-24-12-17(23)20(26-22)31-2/h3,6-7,11-12,16H,1,4-5,8-10,13H2,2H3,(H,24,25,26)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478971
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCCCC2)ncc1Cl
Show InChI InChI=1S/C24H29ClN6O3/c1-3-21(32)28-19-8-7-16(13-20(19)30-10-5-4-6-11-30)23(33)31-12-9-17(15-31)27-24-26-14-18(25)22(29-24)34-2/h3,7-8,13-14,17H,1,4-6,9-12,15H2,2H3,(H,28,32)(H,26,27,29)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478974
PNG
((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Br)c(OC)n1
Show InChI InChI=1S/C19H22BrN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h4-7,10,14H,3,8-9,11H2,1-2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478991
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES COc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O3/c1-3-17(26)24-15-5-4-12(8-16(15)28-2)18(27)25-7-6-14(11-25)23-19-21-9-13(20)10-22-19/h3-5,8-10,14H,1,6-7,11H2,2H3,(H,24,26)(H,21,22,23)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479022
PNG
((R)-N-(4-(3-((5-chloro-4- (methylamino)pyrimidin-2...)
Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H21ClN6O2/c1-3-16(27)23-13-6-4-12(5-7-13)18(28)26-9-8-14(11-26)24-19-22-10-15(20)17(21-2)25-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,23,27)(H2,21,22,24,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479039
PNG
((R)-N-(2-methyl-4-(3-((5- (trifluoromethyl)pyrimid...)
Show SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2/c1-3-17(29)27-16-5-4-13(8-12(16)2)18(30)28-7-6-15(11-28)26-19-24-9-14(10-25-19)20(21,22)23/h3-5,8-10,15H,1,6-7,11H2,2H3,(H,27,29)(H,24,25,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479141
PNG
((R)-N-(4-(3-((5-ethynyl-4- methoxypyrimidin-2- yl)...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C#C
Show InChI InChI=1S/C21H21N5O3/c1-4-14-12-22-21(25-19(14)29-3)24-17-10-11-26(13-17)20(28)15-6-8-16(9-7-15)23-18(27)5-2/h1,5-9,12,17H,2,10-11,13H2,3H3,(H,23,27)(H,22,24,25)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478967
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2csc(NC(=O)C=C)n2)ncc1Cl
Show InChI InChI=1S/C16H17ClN6O3S/c1-3-12(24)21-16-20-11(8-27-16)14(25)23-5-4-9(7-23)19-15-18-6-10(17)13(22-15)26-2/h3,6,8-9H,1,4-5,7H2,2H3,(H,18,19,22)(H,20,21,24)/t9-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478974
PNG
((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Br)c(OC)n1
Show InChI InChI=1S/C19H22BrN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h4-7,10,14H,3,8-9,11H2,1-2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478987
PNG
((R)-1-(5-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCc3c2)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C21H22ClN5O3/c1-3-18(28)27-9-6-13-10-14(4-5-17(13)27)20(29)26-8-7-15(12-26)24-21-23-11-16(22)19(25-21)30-2/h3-5,10-11,15H,1,6-9,12H2,2H3,(H,23,24,25)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479064
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN(C(=O)C=C)c1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C19H20BrN5O2/c1-3-17(26)24(2)16-6-4-13(5-7-16)18(27)25-9-8-15(12-25)23-19-21-10-14(20)11-22-19/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,21,22,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479122
PNG
(N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN1CC[C@H](C1)Oc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C23H27BrN6O3/c1-3-21(31)28-19-5-4-15(10-20(19)33-18-7-8-29(2)14-18)22(32)30-9-6-17(13-30)27-23-25-11-16(24)12-26-23/h3-5,10-12,17-18H,1,6-9,13-14H2,2H3,(H,28,31)(H,25,26,27)/t17-,18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479126
PNG
((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CC[C@@H](F)C3)cc2)ncc1Cl
Show InChI InChI=1S/C24H28ClFN6O3/c1-35-22-20(25)13-27-24(30-22)29-19-9-12-32(15-19)23(34)16-4-6-18(7-5-16)28-21(33)3-2-10-31-11-8-17(26)14-31/h2-7,13,17,19H,8-12,14-15H2,1H3,(H,28,33)(H,27,29,30)/b3-2+/t17-,19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479142
PNG
(N-(4-((2R,4R)-4-((5-chloro-4- methoxypyrimidin-2-y...)
Show SMILES COc1nc(N[C@@H]2C[C@@H](C)N(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)23-14-7-5-13(6-8-14)19(28)26-11-15(9-12(26)2)24-20-22-10-16(21)18(25-20)29-3/h4-8,10,12,15H,1,9,11H2,2-3H3,(H,23,27)(H,22,24,25)/t12-,15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478970
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O4/c1-3-20(31)27-18-5-4-15(12-19(18)29-8-10-34-11-9-29)22(32)30-7-6-16(14-30)26-23-25-13-17(24)21(28-23)33-2/h3-5,12-13,16H,1,6-11,14H2,2H3,(H,27,31)(H,25,26,28)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479007
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478990
PNG
((R)-1-(5-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCc3c2)C(=O)C=C)nc1
Show InChI InChI=1S/C20H20ClN5O2/c1-2-18(27)26-8-5-13-9-14(3-4-17(13)26)19(28)25-7-6-16(12-25)24-20-22-10-15(21)11-23-20/h2-4,9-11,16H,1,5-8,12H2,(H,22,23,24)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479014
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...)
Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478970
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O4/c1-3-20(31)27-18-5-4-15(12-19(18)29-8-10-34-11-9-29)22(32)30-7-6-16(14-30)26-23-25-13-17(24)21(28-23)33-2/h3-5,12-13,16H,1,6-11,14H2,2H3,(H,27,31)(H,25,26,28)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479022
PNG
((R)-N-(4-(3-((5-chloro-4- (methylamino)pyrimidin-2...)
Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H21ClN6O2/c1-3-16(27)23-13-6-4-12(5-7-13)18(28)26-9-8-14(11-26)24-19-22-10-15(20)17(21-2)25-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,23,27)(H2,21,22,24,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479084
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#C)cc2)ncc1Cl
Show InChI InChI=1S/C19H18ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h1,4-7,10,14H,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479084
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#C)cc2)ncc1Cl
Show InChI InChI=1S/C19H18ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h1,4-7,10,14H,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478981
PNG
((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1
Show InChI InChI=1S/C21H22ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478986
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(C)c2)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)24-16-6-5-13(9-12(16)2)19(28)26-8-7-14(11-26)23-20-22-10-15(21)18(25-20)29-3/h4-6,9-10,14H,1,7-8,11H2,2-3H3,(H,24,27)(H,22,23,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479012
PNG
((R)-N-(4-(3-((5-chloro-4- methylpyrimidin-2- yl)am...)
Show SMILES Cc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)23-14-6-4-13(5-7-14)18(27)25-9-8-15(11-25)24-19-21-10-16(20)12(2)22-19/h3-7,10,15H,1,8-9,11H2,2H3,(H,23,26)(H,21,22,24)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478981
PNG
((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1
Show InChI InChI=1S/C21H22ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479048
PNG
((R)-N-(4-(3-((5-chloro-4-(2- methoxyethoxy)pyrimid...)
Show SMILES COCCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C21H24ClN5O4/c1-3-18(28)24-15-6-4-14(5-7-15)20(29)27-9-8-16(13-27)25-21-23-12-17(22)19(26-21)31-11-10-30-2/h3-7,12,16H,1,8-11,13H2,2H3,(H,24,28)(H,23,25,26)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479062
PNG
((R)-N-(4-(3-((5-chloro-4-(2- cyanoethoxy)pyrimidin...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OCCC#N
Show InChI InChI=1S/C21H21ClN6O3/c1-2-18(29)25-15-6-4-14(5-7-15)20(30)28-10-8-16(13-28)26-21-24-12-17(22)19(27-21)31-11-3-9-23/h2,4-7,12,16H,1,3,8,10-11,13H2,(H,25,29)(H,24,26,27)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479097
PNG
((R)-N-(4-(3-((5-chloro-4-(2- hydroxyethoxy)pyrimid...)
Show SMILES OCCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O4/c1-2-17(28)23-14-5-3-13(4-6-14)19(29)26-8-7-15(12-26)24-20-22-11-16(21)18(25-20)30-10-9-27/h2-6,11,15,27H,1,7-10,12H2,(H,23,28)(H,22,24,25)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479046
PNG
((R)-N-(4-(3-((5-chloro-4- (dimethylamino)pyrimidin...)
Show SMILES CN(C)c1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H23ClN6O2/c1-4-17(28)23-14-7-5-13(6-8-14)19(29)27-10-9-15(12-27)24-20-22-11-16(21)18(25-20)26(2)3/h4-8,11,15H,1,9-10,12H2,2-3H3,(H,23,28)(H,22,24,25)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479112
PNG
((R)-N-(6-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cn2)ncc1Cl
Show InChI InChI=1S/C19H21ClN6O3/c1-3-16(27)23-12-5-6-15(21-9-12)18(28)26-8-7-13(11-26)24-19-22-10-14(20)17(25-19)29-4-2/h3,5-6,9-10,13H,1,4,7-8,11H2,2H3,(H,23,27)(H,22,24,25)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479123
PNG
(N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN1CC[C@@H](C1)Oc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C23H27BrN6O3/c1-3-21(31)28-19-5-4-15(10-20(19)33-18-7-8-29(2)14-18)22(32)30-9-6-17(13-30)27-23-25-11-16(24)12-26-23/h3-5,10-12,17-18H,1,6-9,13-14H2,2H3,(H,28,31)(H,25,26,27)/t17-,18+/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479139
PNG
(N-(4-((2S,4R)-4-((5-chloro-4- methoxypyrimidin-2-y...)
Show SMILES COc1nc(N[C@@H]2C[C@H](C)N(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)23-14-7-5-13(6-8-14)19(28)26-11-15(9-12(26)2)24-20-22-10-16(21)18(25-20)29-3/h4-8,10,12,15H,1,9,11H2,2-3H3,(H,23,27)(H,22,24,25)/t12-,15+/m0/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479140
PNG
((R)-N-(4-(3-((5-ethynylpyrimidin-2- yl)amino)pyrro...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C#C
Show InChI InChI=1S/C20H19N5O2/c1-3-14-11-21-20(22-12-14)24-17-9-10-25(13-17)19(27)15-5-7-16(8-6-15)23-18(26)4-2/h1,4-8,11-12,17H,2,9-10,13H2,(H,23,26)(H,21,22,24)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478969
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCN(C)CC2)ncc1C
Show InChI InChI=1S/C25H33N7O3/c1-5-22(33)28-20-7-6-18(14-21(20)31-12-10-30(3)11-13-31)24(34)32-9-8-19(16-32)27-25-26-15-17(2)23(29-25)35-4/h5-7,14-15,19H,1,8-13,16H2,2-4H3,(H,28,33)(H,26,27,29)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478979
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES Brc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C18H18BrN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h2-6,9-10,15H,1,7-8,11H2,(H,22,25)(H,20,21,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478985
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(cc2)N(C)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)25(2)15-7-5-13(6-8-15)19(28)26-10-9-14(12-26)23-20-22-11-16(21)18(24-20)29-3/h4-8,11,14H,1,9-10,12H2,2-3H3,(H,22,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478986
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(C)c2)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)24-16-6-5-13(9-12(16)2)19(28)26-8-7-14(11-26)23-20-22-10-15(21)18(25-20)29-3/h4-6,9-10,14H,1,7-8,11H2,2-3H3,(H,24,27)(H,22,23,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478989
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)24-16-5-4-13(8-12(16)2)18(27)25-7-6-15(11-25)23-19-21-9-14(20)10-22-19/h3-5,8-10,15H,1,6-7,11H2,2H3,(H,24,26)(H,21,22,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479015
PNG
((R)-N-(4-(3-((5-chloro-4- methylpyridin-2- yl)amin...)
Show SMILES Cc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H21ClN4O2/c1-3-19(26)24-15-6-4-14(5-7-15)20(27)25-9-8-16(12-25)23-18-10-13(2)17(21)11-22-18/h3-7,10-11,16H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478963
PNG
((R)-1-(6-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCCc3c2)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C22H24ClN5O3/c1-3-19(29)28-9-4-5-14-11-15(6-7-18(14)28)21(30)27-10-8-16(13-27)25-22-24-12-17(23)20(26-22)31-2/h3,6-7,11-12,16H,1,4-5,8-10,13H2,2H3,(H,24,25,26)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478967
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2csc(NC(=O)C=C)n2)ncc1Cl
Show InChI InChI=1S/C16H17ClN6O3S/c1-3-12(24)21-16-20-11(8-27-16)14(25)23-5-4-9(7-23)19-15-18-6-10(17)13(22-15)26-2/h3,6,8-9H,1,4-5,7H2,2H3,(H,18,19,22)(H,20,21,24)/t9-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478966
PNG
((R)-N-(2-chloro-4-(3-((5- chloropyrimidin-2- yl)am...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(Cl)c2)nc1
Show InChI InChI=1S/C18H17Cl2N5O2/c1-2-16(26)24-15-4-3-11(7-14(15)20)17(27)25-6-5-13(10-25)23-18-21-8-12(19)9-22-18/h2-4,7-9,13H,1,5-6,10H2,(H,24,26)(H,21,22,23)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479050
PNG
((R)-N-(4-(3-((4-amino-5- chloropyrimidin-2- yl)ami...)
Show SMILES Nc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C18H19ClN6O2/c1-2-15(26)22-12-5-3-11(4-6-12)17(27)25-8-7-13(10-25)23-18-21-9-14(19)16(20)24-18/h2-6,9,13H,1,7-8,10H2,(H,22,26)(H3,20,21,23,24)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479007
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479056
PNG
((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-3-17(27)23-14-7-5-13(6-8-14)19(28)26-10-9-15(12-26)24-20-22-11-16(21)18(25-20)29-4-2/h3,5-8,11,15H,1,4,9-10,12H2,2H3,(H,23,27)(H,22,24,25)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479080
PNG
((R)-N-(4-(3-((4-(methylamino)-5- (trifluoromethyl)...)
Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O2/c1-3-16(30)26-13-6-4-12(5-7-13)18(31)29-9-8-14(11-29)27-19-25-10-15(20(21,22)23)17(24-2)28-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,26,30)(H2,24,25,27,28)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479124
PNG
((R)-N-(4-(3-((5-cyano-4- methoxypyrimidin-2- yl)am...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OCCN(C)C)c2)ncc1C#N
Show InChI InChI=1S/C24H29N7O4/c1-5-21(32)28-19-7-6-16(12-20(19)35-11-10-30(2)3)23(33)31-9-8-18(15-31)27-24-26-14-17(13-25)22(29-24)34-4/h5-7,12,14,18H,1,8-11,15H2,2-4H3,(H,28,32)(H,26,27,29)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479128
PNG
((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CC[C@H](F)C3)cc2)ncc1Cl
Show InChI InChI=1S/C24H28ClFN6O3/c1-35-22-20(25)13-27-24(30-22)29-19-9-12-32(15-19)23(34)16-4-6-18(7-5-16)28-21(33)3-2-10-31-11-8-17(26)14-31/h2-7,13,17,19H,8-12,14-15H2,1H3,(H,28,33)(H,27,29,30)/b3-2+/t17-,19+/m0/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479143
PNG
(US10894788, Example 184Biochemical)
Show SMILES FC(F)(F)c1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C19H18F3N5O2/c1-2-16(28)25-14-5-3-12(4-6-14)17(29)27-8-7-15(11-27)26-18-23-9-13(10-24-18)19(20,21)22/h2-6,9-10,15H,1,7-8,11H2,(H,25,28)(H,23,24,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478980
PNG
((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Br
Show InChI InChI=1S/C19H20BrN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478984
PNG
((R)-N-(4-(3-((5-chloro-4-(2,2,2- trifluoroethoxy)p...)
Show SMILES FC(F)(F)COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H19ClF3N5O3/c1-2-16(30)26-13-5-3-12(4-6-13)18(31)29-8-7-14(10-29)27-19-25-9-15(21)17(28-19)32-11-20(22,23)24/h2-6,9,14H,1,7-8,10-11H2,(H,26,30)(H,25,27,28)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479007
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479014
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...)
Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478965
PNG
((R)-N-(2-chloro-4-(3-((5-chloro-4- methoxypyrimidi...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(Cl)c2)ncc1Cl
Show InChI InChI=1S/C19H19Cl2N5O3/c1-3-16(27)24-15-5-4-11(8-13(15)20)18(28)26-7-6-12(10-26)23-19-22-9-14(21)17(25-19)29-2/h3-5,8-9,12H,1,6-7,10H2,2H3,(H,24,27)(H,22,23,25)/t12-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478971
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCCCC2)ncc1Cl
Show InChI InChI=1S/C24H29ClN6O3/c1-3-21(32)28-19-8-7-16(13-20(19)30-10-5-4-6-11-30)23(33)31-12-9-17(15-31)27-24-26-14-18(25)22(29-24)34-2/h3,7-8,13-14,17H,1,4-6,9-12,15H2,2H3,(H,28,32)(H,26,27,29)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479051
PNG
((R)-N-(4-(3-((4-amino-5- (trifluoromethyl)pyrimidi...)
Show SMILES Nc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O2/c1-2-15(29)25-12-5-3-11(4-6-12)17(30)28-8-7-13(10-28)26-18-24-9-14(16(23)27-18)19(20,21)22/h2-6,9,13H,1,7-8,10H2,(H,25,29)(H3,23,24,26,27)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479007
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478965
PNG
((R)-N-(2-chloro-4-(3-((5-chloro-4- methoxypyrimidi...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(Cl)c2)ncc1Cl
Show InChI InChI=1S/C19H19Cl2N5O3/c1-3-16(27)24-15-5-4-11(8-13(15)20)18(28)26-7-6-12(10-26)23-19-22-9-14(21)17(25-19)29-2/h3-5,8-9,12H,1,6-7,10H2,2H3,(H,24,27)(H,22,23,25)/t12-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478966
PNG
((R)-N-(2-chloro-4-(3-((5- chloropyrimidin-2- yl)am...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(Cl)c2)nc1
Show InChI InChI=1S/C18H17Cl2N5O2/c1-2-16(26)24-15-4-3-11(7-14(15)20)17(27)25-6-5-13(10-25)23-18-21-8-12(19)9-22-18/h2-4,7-9,13H,1,5-6,10H2,(H,24,26)(H,21,22,23)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478979
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES Brc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C18H18BrN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h2-6,9-10,15H,1,7-8,11H2,(H,22,25)(H,20,21,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478980
PNG
((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Br
Show InChI InChI=1S/C19H20BrN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478985
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(cc2)N(C)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)25(2)15-7-5-13(6-8-15)19(28)26-10-9-14(12-26)23-20-22-11-16(21)18(24-20)29-3/h4-8,11,14H,1,9-10,12H2,2-3H3,(H,22,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478968
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2cnc(NC(=O)C=C)s2)ncc1Cl
Show InChI InChI=1S/C16H17ClN6O3S/c1-3-12(24)21-16-19-7-11(27-16)14(25)23-5-4-9(8-23)20-15-18-6-10(17)13(22-15)26-2/h3,6-7,9H,1,4-5,8H2,2H3,(H,18,20,22)(H,19,21,24)/t9-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478978
PNG
((R)-N-(4-(3-((5-chloro-4-(2,2,2- trifluoroethoxy)p...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)c(OCC(F)(F)F)n1
Show InChI InChI=1S/C20H21ClF3N5O3/c1-2-16(30)26-13-5-3-12(4-6-13)18(31)29-8-7-14(10-29)27-19-25-9-15(21)17(28-19)32-11-20(22,23)24/h3-6,9,14H,2,7-8,10-11H2,1H3,(H,26,30)(H,25,27,28)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479020
PNG
((R)-N-(4-(3-((5- (trifluoromethyl)pyrazin-2- yl)am...)
Show SMILES FC(F)(F)c1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)cn1
Show InChI InChI=1S/C19H18F3N5O2/c1-2-17(28)26-13-5-3-12(4-6-13)18(29)27-8-7-14(11-27)25-16-10-23-15(9-24-16)19(20,21)22/h2-6,9-10,14H,1,7-8,11H2,(H,24,25)(H,26,28)/t14-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479040
PNG
((R)-N-(4-(3-((5-chloro-4- methylpyrimidin-2- yl)am...)
Show SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)c(C)n1
Show InChI InChI=1S/C20H22ClN5O2/c1-4-18(27)25-17-6-5-14(9-12(17)2)19(28)26-8-7-15(11-26)24-20-22-10-16(21)13(3)23-20/h4-6,9-10,15H,1,7-8,11H2,2-3H3,(H,25,27)(H,22,23,24)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478982
PNG
((R)-N-(4-(3-((4-cyclopropoxy-5- methylpyrimidin-2-...)
Show SMILES Cc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1
Show InChI InChI=1S/C22H25N5O3/c1-3-19(28)24-16-6-4-15(5-7-16)21(29)27-11-10-17(13-27)25-22-23-12-14(2)20(26-22)30-18-8-9-18/h3-7,12,17-18H,1,8-11,13H2,2H3,(H,24,28)(H,23,25,26)/t17-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479047
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C18H18ClN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h2-6,9-10,15H,1,7-8,11H2,(H,22,25)(H,20,21,23)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479054
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2csc(NC(=O)C=C)n2)nc1
Show InChI InChI=1S/C15H15ClN6O2S/c1-2-12(23)21-15-20-11(8-25-15)13(24)22-4-3-10(7-22)19-14-17-5-9(16)6-18-14/h2,5-6,8,10H,1,3-4,7H2,(H,17,18,19)(H,20,21,23)/t10-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479060
PNG
((R)-N-(4-(3-((5- (trifluoromethyl)pyrimidin-2- yl)...)
Show SMILES FC(F)(F)c1cnc(N[C@@H]2CCN(C2)C(=O)c2csc(NC(=O)C=C)n2)nc1
Show InChI InChI=1S/C16H15F3N6O2S/c1-2-12(26)24-15-23-11(8-28-15)13(27)25-4-3-10(7-25)22-14-20-5-9(6-21-14)16(17,18)19/h2,5-6,8,10H,1,3-4,7H2,(H,20,21,22)(H,23,24,26)/t10-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479063
PNG
(N-(4-((R)-3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OC3CCOC3)c2)nc1
Show InChI InChI=1S/C22H24ClN5O4/c1-2-20(29)27-18-4-3-14(9-19(18)32-17-6-8-31-13-17)21(30)28-7-5-16(12-28)26-22-24-10-15(23)11-25-22/h2-4,9-11,16-17H,1,5-8,12-13H2,(H,27,29)(H,24,25,26)/t16-,17?/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479077
PNG
((R,E)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN(C)C)c(C)c2)ncc1Cl
Show InChI InChI=1S/C23H29ClN6O3/c1-15-12-16(7-8-19(15)27-20(31)6-5-10-29(2)3)22(32)30-11-9-17(14-30)26-23-25-13-18(24)21(28-23)33-4/h5-8,12-13,17H,9-11,14H2,1-4H3,(H,27,31)(H,25,26,28)/b6-5+/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479086
PNG
((R)-1-(4-(3-((5-chloro-4- (trideuteromethoxy)pyrim...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(cc2)N2C(=O)C=CC2=O)ncc1Cl
Show InChI InChI=1S/C20H18ClN5O4/c1-30-18-15(21)10-22-20(24-18)23-13-8-9-25(11-13)19(29)12-2-4-14(5-3-12)26-16(27)6-7-17(26)28/h2-7,10,13H,8-9,11H2,1H3,(H,22,23,24)/t13-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479087
PNG
(N-(4-((R)-3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES CN(C)C1CCN(C1)c1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C24H30ClN7O2/c1-4-22(33)29-20-6-5-16(11-21(20)31-10-8-19(15-31)30(2)3)23(34)32-9-7-18(14-32)28-24-26-12-17(25)13-27-24/h4-6,11-13,18-19H,1,7-10,14-15H2,2-3H3,(H,29,33)(H,26,27,28)/t18-,19?/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479130
PNG
((E)-N-(6-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CC[C@H](F)C3)cn2)ncc1Cl
Show InChI InChI=1S/C23H27ClFN7O3/c1-35-21-18(24)12-27-23(30-21)29-17-7-10-32(14-17)22(34)19-5-4-16(11-26-19)28-20(33)3-2-8-31-9-6-15(25)13-31/h2-5,11-12,15,17H,6-10,13-14H2,1H3,(H,28,33)(H,27,29,30)/b3-2+/t15-,17+/m0/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479134
PNG
((E)-N-(6-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CCC[C@H](F)C3)cn2)ncc1Cl
Show InChI InChI=1S/C24H29ClFN7O3/c1-36-22-19(25)13-28-24(31-22)30-18-8-11-33(15-18)23(35)20-7-6-17(12-27-20)29-21(34)5-3-10-32-9-2-4-16(26)14-32/h3,5-7,12-13,16,18H,2,4,8-11,14-15H2,1H3,(H,29,34)(H,28,30,31)/b5-3+/t16-,18+/m0/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479138
PNG
((E)-N-(5-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CC[C@@H](F)C3)nc2)ncc1Cl
Show InChI InChI=1S/C23H27ClFN7O3/c1-35-21-18(24)12-27-23(30-21)28-17-7-10-32(14-17)22(34)15-4-5-19(26-11-15)29-20(33)3-2-8-31-9-6-16(25)13-31/h2-5,11-12,16-17H,6-10,13-14H2,1H3,(H,26,29,33)(H,27,28,30)/b3-2+/t16-,17-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478964
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)-c2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C23H24ClN7O3/c1-4-20(32)28-19-6-5-14(9-17(19)15-10-26-30(2)12-15)22(33)31-8-7-16(13-31)27-23-25-11-18(24)21(29-23)34-3/h4-6,9-12,16H,1,7-8,13H2,2-3H3,(H,28,32)(H,25,27,29)/t16-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478975
PNG
((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)c(OC2CC2)n1
Show InChI InChI=1S/C21H24ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h3-6,11,15-16H,2,7-10,12H2,1H3,(H,24,28)(H,23,25,26)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478977
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C18H20BrN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h3-6,9-10,15H,2,7-8,11H2,1H3,(H,22,25)(H,20,21,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478983
PNG
((R)-N-(4-(3-((4-cyclopropoxy-5- fluoropyrimidin-2-...)
Show SMILES Fc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1
Show InChI InChI=1S/C21H22FN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479061
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCCN(C2)C(=O)c2csc(NC(=O)C=C)n2)ncc1Cl
Show InChI InChI=1S/C17H19ClN6O3S/c1-3-13(25)22-17-21-12(9-28-17)15(26)24-6-4-5-10(8-24)20-16-19-7-11(18)14(23-16)27-2/h3,7,9-10H,1,4-6,8H2,2H3,(H,19,20,23)(H,21,22,25)/t10-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479072
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C22H27ClN6O3/c1-4-20(30)27-18-6-5-15(11-19(18)32-10-9-28(2)3)21(31)29-8-7-17(14-29)26-22-24-12-16(23)13-25-22/h4-6,11-13,17H,1,7-10,14H2,2-3H3,(H,27,30)(H,24,25,26)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479094
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES CN(C)\C=C(/C#N)C(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C21H22ClN7O2/c1-28(2)12-15(9-23)19(30)26-17-5-3-14(4-6-17)20(31)29-8-7-18(13-29)27-21-24-10-16(22)11-25-21/h3-6,10-12,18H,7-8,13H2,1-2H3,(H,26,30)(H,24,25,27)/b15-12+/t18-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479105
PNG
((R,E)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN(C)C)c(F)c2)ncc1Cl
Show InChI InChI=1S/C22H26ClFN6O3/c1-29(2)9-4-5-19(31)27-18-7-6-14(11-17(18)24)21(32)30-10-8-15(13-30)26-22-25-12-16(23)20(28-22)33-3/h4-7,11-12,15H,8-10,13H2,1-3H3,(H,27,31)(H,25,26,28)/b5-4+/t15-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479116
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES Brc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OCCN3CCOCC3)c2)nc1
Show InChI InChI=1S/C24H29BrN6O4/c1-2-22(32)29-20-4-3-17(13-21(20)35-12-9-30-7-10-34-11-8-30)23(33)31-6-5-19(16-31)28-24-26-14-18(25)15-27-24/h2-4,13-15,19H,1,5-12,16H2,(H,29,32)(H,26,27,28)/t19-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479125
PNG
((R)-N-(4-(3-((5-cyanopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C#N
Show InChI InChI=1S/C23H27N7O3/c1-4-21(31)28-19-6-5-17(11-20(19)33-10-9-29(2)3)22(32)30-8-7-18(15-30)27-23-25-13-16(12-24)14-26-23/h4-6,11,13-14,18H,1,7-10,15H2,2-3H3,(H,28,31)(H,25,26,27)/t18-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479132
PNG
((R,E)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CCCC(F)(F)C3)cc2)ncc1Cl
Show InChI InChI=1S/C25H29ClF2N6O3/c1-37-22-20(26)14-29-24(32-22)31-19-9-13-34(15-19)23(36)17-5-7-18(8-6-17)30-21(35)4-2-11-33-12-3-10-25(27,28)16-33/h2,4-8,14,19H,3,9-13,15-16H2,1H3,(H,30,35)(H,29,31,32)/b4-2+/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479133
PNG
((R,E)-N-(6-(3-((5-chloro-4- methoxypyrimidin-2- yl...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CCOCC3)cn2)ncc1Cl
Show InChI InChI=1S/C23H28ClN7O4/c1-34-21-18(24)14-26-23(29-21)28-17-6-8-31(15-17)22(33)19-5-4-16(13-25-19)27-20(32)3-2-7-30-9-11-35-12-10-30/h2-5,13-14,17H,6-12,15H2,1H3,(H,27,32)(H,26,28,29)/b3-2+/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479135
PNG
((E)-N-(6-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CCC[C@@H](F)C3)cn2)ncc1Cl
Show InChI InChI=1S/C24H29ClFN7O3/c1-36-22-19(25)13-28-24(31-22)30-18-8-11-33(15-18)23(35)20-7-6-17(12-27-20)29-21(34)5-3-10-32-9-2-4-16(26)14-32/h3,5-7,12-13,16,18H,2,4,8-11,14-15H2,1H3,(H,29,34)(H,28,30,31)/b5-3+/t16-,18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478988
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES CN(C(=O)C=C)c1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)24(2)16-6-4-13(5-7-16)18(27)25-9-8-15(12-25)23-19-21-10-14(20)11-22-19/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,21,22,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478994
PNG
((R)-1-(7-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCOc3c2)C(=O)C=C)nc1
Show InChI InChI=1S/C20H20ClN5O3/c1-2-18(27)26-7-8-29-17-9-13(3-4-16(17)26)19(28)25-6-5-15(12-25)24-20-22-10-14(21)11-23-20/h2-4,9-11,15H,1,5-8,12H2,(H,22,23,24)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479049
PNG
((R)-N-(4-(3-((4-(azetidin-1-yl)-5- chloropyrimidin...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1N1CCC1
Show InChI InChI=1S/C21H23ClN6O2/c1-2-18(29)24-15-6-4-14(5-7-15)20(30)28-11-8-16(13-28)25-21-23-12-17(22)19(26-21)27-9-3-10-27/h2,4-7,12,16H,1,3,8-11,13H2,(H,24,29)(H,23,25,26)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479073
PNG
((R)-N-(4-(3-((5-ethynylpyrimidin-2- yl)amino)pyrro...)
Show SMILES CCc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(cc2)N(C)C(=O)C=C)nc1
Show InChI InChI=1S/C21H25N5O2/c1-4-15-12-22-21(23-13-15)24-17-10-11-26(14-17)20(28)16-6-8-18(9-7-16)25(3)19(27)5-2/h5-9,12-13,17H,2,4,10-11,14H2,1,3H3,(H,22,23,24)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479131
PNG
((R,E)-N-(6-(3-((5-chloro-4- methoxypyrimidin-2- yl...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OCCN3CCCC(F)(F)C3)c2)ncc1Cl
Show InChI InChI=1S/C26H31ClF2N6O4/c1-3-22(36)32-20-6-5-17(13-21(20)39-12-11-34-9-4-8-26(28,29)16-34)24(37)35-10-7-18(15-35)31-25-30-14-19(27)23(33-25)38-2/h3,5-6,13-14,18H,1,4,7-12,15-16H2,2H3,(H,32,36)(H,30,31,33)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478983
PNG
((R)-N-(4-(3-((4-cyclopropoxy-5- fluoropyrimidin-2-...)
Show SMILES Fc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1
Show InChI InChI=1S/C21H22FN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479004
PNG
((R)-N-(4-(3-((4-(1H-pyrazol-4- yl)pyrimidin-2-yl)a...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1nccc(n1)-c1cn[nH]c1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479012
PNG
((R)-N-(4-(3-((5-chloro-4- methylpyrimidin-2- yl)am...)
Show SMILES Cc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)23-14-6-4-13(5-7-14)18(27)25-9-8-15(11-25)24-19-21-10-16(20)12(2)22-19/h3-7,10,15H,1,8-9,11H2,2H3,(H,23,26)(H,21,22,24)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479013
PNG
((R)-N-(4-(3-((5-chloropyrazin-2- yl)amino)pyrrolid...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)cn1
Show InChI InChI=1S/C18H18ClN5O2/c1-2-17(25)23-13-5-3-12(4-6-13)18(26)24-8-7-14(11-24)22-16-10-20-15(19)9-21-16/h2-6,9-10,14H,1,7-8,11H2,(H,21,22)(H,23,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479015
PNG
((R)-N-(4-(3-((5-chloro-4- methylpyridin-2- yl)amin...)
Show SMILES Cc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C20H21ClN4O2/c1-3-19(26)24-15-6-4-14(5-7-15)20(27)25-9-8-16(12-25)23-18-10-13(2)17(21)11-22-18/h3-7,10-11,16H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479017
PNG
((R)-N-(4-(3-((5-methylpyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C19H21N5O2/c1-3-17(25)22-15-6-4-14(5-7-15)18(26)24-9-8-16(12-24)23-19-20-10-13(2)11-21-19/h3-7,10-11,16H,1,8-9,12H2,2H3,(H,22,25)(H,20,21,23)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479024
PNG
((R)-N-(4-(3-((5-chloropyridin-2- yl)amino)pyrrolid...)
Show SMILES Clc1ccc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C19H19ClN4O2/c1-2-18(25)23-15-6-3-13(4-7-15)19(26)24-10-9-16(12-24)22-17-8-5-14(20)11-21-17/h2-8,11,16H,1,9-10,12H2,(H,21,22)(H,23,25)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479059
PNG
((R)-N-(4-(3-((5-cyclopropyl-4- methoxypyrimidin-2-...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C1CC1
Show InChI InChI=1S/C22H25N5O3/c1-3-19(28)24-16-8-6-15(7-9-16)21(29)27-11-10-17(13-27)25-22-23-12-18(14-4-5-14)20(26-22)30-2/h3,6-9,12,14,17H,1,4-5,10-11,13H2,2H3,(H,24,28)(H,23,25,26)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479074
PNG
((R,E)-N-(4-(3-((5-chloro-4- (trideuteromethoxy)pyr...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN(C)C)cc2)ncc1Cl
Show InChI InChI=1S/C22H27ClN6O3/c1-28(2)11-4-5-19(30)25-16-8-6-15(7-9-16)21(31)29-12-10-17(14-29)26-22-24-13-18(23)20(27-22)32-3/h4-9,13,17H,10-12,14H2,1-3H3,(H,25,30)(H,24,26,27)/b5-4+/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479079
PNG
((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCN(C)CC2)ncc1Cl
Show InChI InChI=1S/C25H32ClN7O3/c1-4-22(34)29-20-7-6-17(14-21(20)32-12-10-31(3)11-13-32)24(35)33-9-8-18(16-33)28-25-27-15-19(26)23(30-25)36-5-2/h4,6-7,14-15,18H,1,5,8-13,16H2,2-3H3,(H,29,34)(H,27,28,30)/t18-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479083
PNG
((R)-N-(4-(3-((5-chloro-4-(2- ethoxyethoxy)pyrimidi...)
Show SMILES CCOCCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCN(C)CC2)ncc1Cl
Show InChI InChI=1S/C27H36ClN7O4/c1-4-24(36)31-22-7-6-19(16-23(22)34-12-10-33(3)11-13-34)26(37)35-9-8-20(18-35)30-27-29-17-21(28)25(32-27)39-15-14-38-5-2/h4,6-7,16-17,20H,1,5,8-15,18H2,2-3H3,(H,31,36)(H,29,30,32)/t20-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479090
PNG
((R)-1-(7-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3CCN(Cc3c2)C(=O)C=C)nc1
Show InChI InChI=1S/C21H22ClN5O2/c1-2-19(28)26-7-5-14-3-4-15(9-16(14)12-26)20(29)27-8-6-18(13-27)25-21-23-10-17(22)11-24-21/h2-4,9-11,18H,1,5-8,12-13H2,(H,23,24,25)/t18-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479110
PNG
((R,E)-N-(6-(3-((5-chloro-4- methoxypyrimidin-2- yl...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\C)cn2)ncc1Cl
Show InChI InChI=1S/C19H21ClN6O3/c1-3-4-16(27)23-12-5-6-15(21-9-12)18(28)26-8-7-13(11-26)24-19-22-10-14(20)17(25-19)29-2/h3-6,9-10,13H,7-8,11H2,1-2H3,(H,23,27)(H,22,24,25)/b4-3+/t13-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479121
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES FC1(F)CCN(CCOc2cc(ccc2NC(=O)C=C)C(=O)N2CC[C@H](C2)Nc2ncc(Br)cn2)CC1
Show InChI InChI=1S/C25H29BrF2N6O3/c1-2-22(35)32-20-4-3-17(13-21(20)37-12-11-33-9-6-25(27,28)7-10-33)23(36)34-8-5-19(16-34)31-24-29-14-18(26)15-30-24/h2-4,13-15,19H,1,5-12,16H2,(H,32,35)(H,29,30,31)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479127
PNG
((R,E)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CCOCC3)cc2)ncc1Cl
Show InChI InChI=1S/C24H29ClN6O4/c1-34-22-20(25)15-26-24(29-22)28-19-8-10-31(16-19)23(33)17-4-6-18(7-5-17)27-21(32)3-2-9-30-11-13-35-14-12-30/h2-7,15,19H,8-14,16H2,1H3,(H,27,32)(H,26,28,29)/b3-2+/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479037
PNG
((R)-N-(6-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(cn2)N(C)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C19H21ClN6O3/c1-4-16(27)25(2)13-5-6-15(21-9-13)18(28)26-8-7-12(11-26)23-19-22-10-14(20)17(24-19)29-3/h4-6,9-10,12H,1,7-8,11H2,2-3H3,(H,22,23,24)/t12-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479107
PNG
((R)-N-(4-(3-((5-cyanopyridin-2- yl)amino)pyrrolidi...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ccc(cn1)C#N
Show InChI InChI=1S/C20H19N5O2/c1-2-19(26)24-16-6-4-15(5-7-16)20(27)25-10-9-17(13-25)23-18-8-3-14(11-21)12-22-18/h2-8,12,17H,1,9-10,13H2,(H,22,23)(H,24,26)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479113
PNG
((R)-N-(4-(3-((5-chloro-4-(2- ethoxyethoxy)pyrimidi...)
Show SMILES CCOCCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C22H26ClN5O4/c1-3-19(29)25-16-7-5-15(6-8-16)21(30)28-10-9-17(14-28)26-22-24-13-18(23)20(27-22)32-12-11-31-4-2/h3,5-8,13,17H,1,4,9-12,14H2,2H3,(H,25,29)(H,24,26,27)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478962
PNG
((R)-1-(7-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCOc3c2)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C21H22ClN5O4/c1-3-18(28)27-8-9-31-17-10-13(4-5-16(17)27)20(29)26-7-6-14(12-26)24-21-23-11-15(22)19(25-21)30-2/h3-5,10-11,14H,1,6-9,12H2,2H3,(H,23,24,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478972
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cn1cc(cn1)-c1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-20(31)28-19-5-4-14(8-18(19)15-9-26-29(2)12-15)21(32)30-7-6-17(13-30)27-22-24-10-16(23)11-25-22/h3-5,8-12,17H,1,6-7,13H2,2H3,(H,28,31)(H,24,25,27)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478977
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C18H20BrN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h3-6,9-10,15H,2,7-8,11H2,1H3,(H,22,25)(H,20,21,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478988
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES CN(C(=O)C=C)c1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)24(2)16-6-4-13(5-7-16)18(27)25-9-8-15(12-25)23-19-21-10-14(20)11-22-19/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,21,22,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478989
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)24-16-5-4-13(8-12(16)2)18(27)25-7-6-15(11-25)23-19-21-9-14(20)10-22-19/h3-5,8-10,15H,1,6-7,11H2,2H3,(H,24,26)(H,21,22,23)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479013
PNG
((R)-N-(4-(3-((5-chloropyrazin-2- yl)amino)pyrrolid...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)cn1
Show InChI InChI=1S/C18H18ClN5O2/c1-2-17(25)23-13-5-3-12(4-6-13)18(26)24-8-7-14(11-24)22-16-10-20-15(19)9-21-16/h2-6,9-10,14H,1,7-8,11H2,(H,21,22)(H,23,25)/t14-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479019
PNG
((R)-N-(4-(3-((5-fluoro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1F
Show InChI InChI=1S/C19H20FN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478962
PNG
((R)-1-(7-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCOc3c2)C(=O)C=C)ncc1Cl
Show InChI InChI=1S/C21H22ClN5O4/c1-3-18(28)27-8-9-31-17-10-13(4-5-16(17)27)20(29)26-7-6-14(12-26)24-21-23-11-15(22)19(25-21)30-2/h3-5,10-11,14H,1,6-9,12H2,2H3,(H,23,24,25)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479030
PNG
((R)-N-(4-(3-((5-cyanopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN(C(=O)C=C)c1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C#N
Show InChI InChI=1S/C20H20N6O2/c1-3-18(27)25(2)17-6-4-15(5-7-17)19(28)26-9-8-16(13-26)24-20-22-11-14(10-21)12-23-20/h3-7,11-12,16H,1,8-9,13H2,2H3,(H,22,23,24)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478964
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)-c2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C23H24ClN7O3/c1-4-20(32)28-19-6-5-14(9-17(19)15-10-26-30(2)12-15)22(33)31-8-7-16(13-31)27-23-25-11-18(24)21(29-23)34-3/h4-6,9-12,16H,1,7-8,13H2,2-3H3,(H,28,32)(H,25,27,29)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479044
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NS(=O)(=O)C=C)cc2)nc1
Show InChI InChI=1S/C17H18ClN5O3S/c1-2-27(25,26)22-14-5-3-12(4-6-14)16(24)23-8-7-15(11-23)21-17-19-9-13(18)10-20-17/h2-6,9-10,15,22H,1,7-8,11H2,(H,19,20,21)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479065
PNG
((R)-N-(3-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2cccc(NC(=O)C=C)c2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O3/c1-3-16(26)22-13-6-4-5-12(9-13)18(27)25-8-7-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-6,9-10,14H,1,7-8,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479074
PNG
((R,E)-N-(4-(3-((5-chloro-4- (trideuteromethoxy)pyr...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN(C)C)cc2)ncc1Cl
Show InChI InChI=1S/C22H27ClN6O3/c1-28(2)11-4-5-19(30)25-16-8-6-15(7-9-16)21(31)29-12-10-17(14-29)26-22-24-13-18(23)20(27-22)32-3/h4-9,13,17H,10-12,14H2,1-3H3,(H,25,30)(H,24,26,27)/b5-4+/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479089
PNG
((R,E)-1-(8-(3-((5-chloropyrimidin-2- yl)amino)pyrr...)
Show SMILES CN(C)C\C=C\C(=O)N1CCOc2c1cccc2C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C23H27ClN6O3/c1-28(2)9-4-7-20(31)30-11-12-33-21-18(5-3-6-19(21)30)22(32)29-10-8-17(15-29)27-23-25-13-16(24)14-26-23/h3-7,13-14,17H,8-12,15H2,1-2H3,(H,25,26,27)/b7-4+/t17-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479091
PNG
((R,E)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrr...)
Show SMILES C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-2-3-17(26)23-15-6-4-13(5-7-15)18(27)25-9-8-16(12-25)24-19-21-10-14(20)11-22-19/h2-7,10-11,16H,8-9,12H2,1H3,(H,23,26)(H,21,22,24)/b3-2+/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479096
PNG
((R)-1-(6-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3CCN(C(=O)C=C)c3c2)nc1
Show InChI InChI=1S/C20H20ClN5O2/c1-2-18(27)26-8-5-13-3-4-14(9-17(13)26)19(28)25-7-6-16(12-25)24-20-22-10-15(21)11-23-20/h2-4,9-11,16H,1,5-8,12H2,(H,22,23,24)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478992
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cc1cc(NC(=O)C=C)ccc1C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)23-14-4-5-16(12(2)8-14)18(27)25-7-6-15(11-25)24-19-21-9-13(20)10-22-19/h3-5,8-10,15H,1,6-7,11H2,2H3,(H,23,26)(H,21,22,24)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478972
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cn1cc(cn1)-c1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-20(31)28-19-5-4-14(8-18(19)15-9-26-29(2)12-15)21(32)30-7-6-17(13-30)27-22-24-10-16(23)11-25-22/h3-5,8-12,17H,1,6-7,13H2,2H3,(H,28,31)(H,24,25,27)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478968
PNG
((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2cnc(NC(=O)C=C)s2)ncc1Cl
Show InChI InChI=1S/C16H17ClN6O3S/c1-3-12(24)21-16-19-7-11(27-16)14(25)23-5-4-9(8-23)20-15-18-6-10(17)13(22-15)26-2/h3,6-7,9H,1,4-5,8H2,2H3,(H,18,20,22)(H,19,21,24)/t9-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479043
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES CCC(=C)C(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C20H22ClN5O2/c1-3-13(2)18(27)24-16-6-4-14(5-7-16)19(28)26-9-8-17(12-26)25-20-22-10-15(21)11-23-20/h4-7,10-11,17H,2-3,8-9,12H2,1H3,(H,24,27)(H,22,23,25)/t17-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479093
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)CC#N)cc2)nc1
Show InChI InChI=1S/C18H17ClN6O2/c19-13-9-21-18(22-10-13)24-15-6-8-25(11-15)17(27)12-1-3-14(4-2-12)23-16(26)5-7-20/h1-4,9-10,15H,5-6,8,11H2,(H,23,26)(H,21,22,24)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479108
PNG
((R)-N-(4-(3-((5-cyanopyrimidin-2- yl)amino)pyrroli...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C#N
Show InChI InChI=1S/C19H18N6O2/c1-2-17(26)23-15-5-3-14(4-6-15)18(27)25-8-7-16(12-25)24-19-21-10-13(9-20)11-22-19/h2-6,10-11,16H,1,7-8,12H2,(H,23,26)(H,21,22,24)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479118
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN(C)C1CCN(CC1)c1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C25H32BrN7O2/c1-4-23(34)30-21-6-5-17(13-22(21)32-11-8-20(9-12-32)31(2)3)24(35)33-10-7-19(16-33)29-25-27-14-18(26)15-28-25/h4-6,13-15,19-20H,1,7-12,16H2,2-3H3,(H,30,34)(H,27,28,29)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479136
PNG
((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CCC[C@H](F)C3)cc2)ncc1Cl
Show InChI InChI=1S/C25H30ClFN6O3/c1-36-23-21(26)14-28-25(31-23)30-20-10-13-33(16-20)24(35)17-6-8-19(9-7-17)29-22(34)5-3-12-32-11-2-4-18(27)15-32/h3,5-9,14,18,20H,2,4,10-13,15-16H2,1H3,(H,29,34)(H,28,30,31)/b5-3+/t18-,20+/m0/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479137
PNG
((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CCC[C@@H](F)C3)cc2)ncc1Cl
Show InChI InChI=1S/C25H30ClFN6O3/c1-36-23-21(26)14-28-25(31-23)30-20-10-13-33(16-20)24(35)17-6-8-19(9-7-17)29-22(34)5-3-12-32-11-2-4-18(27)15-32/h3,5-9,14,18,20H,2,4,10-13,15-16H2,1H3,(H,29,34)(H,28,30,31)/b5-3+/t18-,20-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478982
PNG
((R)-N-(4-(3-((4-cyclopropoxy-5- methylpyrimidin-2-...)
Show SMILES Cc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1
Show InChI InChI=1S/C22H25N5O3/c1-3-19(28)24-16-6-4-15(5-7-16)21(29)27-11-10-17(13-27)25-22-23-12-14(2)20(26-22)30-18-8-9-18/h3-7,12,17-18H,1,8-11,13H2,2H3,(H,24,28)(H,23,25,26)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478994
PNG
((R)-1-(7-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCOc3c2)C(=O)C=C)nc1
Show InChI InChI=1S/C20H20ClN5O3/c1-2-18(27)26-7-8-29-17-9-13(3-4-16(17)26)19(28)25-6-5-15(12-25)24-20-22-10-14(21)11-23-20/h2-4,9-11,15H,1,5-8,12H2,(H,22,23,24)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479005
PNG
((R)-N-(4-(3-((4- (cyclopentyloxy)pyrimidin-2- yl)a...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1nccc(OC2CCCC2)n1
Show InChI InChI=1S/C23H27N5O3/c1-2-20(29)25-17-9-7-16(8-10-17)22(30)28-14-12-18(15-28)26-23-24-13-11-21(27-23)31-19-5-3-4-6-19/h2,7-11,13,18-19H,1,3-6,12,14-15H2,(H,25,29)(H,24,26,27)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479008
PNG
((R)-N-(4-(3-((4-(thiazol-5- yl)pyrimidin-2-yl)amin...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1nccc(n1)-c1cncs1
Show InChI InChI=1S/C21H20N6O2S/c1-2-19(28)24-15-5-3-14(4-6-15)20(29)27-10-8-16(12-27)25-21-23-9-7-17(26-21)18-11-22-13-30-18/h2-7,9,11,13,16H,1,8,10,12H2,(H,24,28)(H,23,25,26)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479018
PNG
((R)-N-(4-(3-((5- cyclopropylpyrimidin-2- yl)amino)...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C1CC1
Show InChI InChI=1S/C21H23N5O2/c1-2-19(27)24-17-7-5-15(6-8-17)20(28)26-10-9-18(13-26)25-21-22-11-16(12-23-21)14-3-4-14/h2,5-8,11-12,14,18H,1,3-4,9-10,13H2,(H,24,27)(H,22,23,25)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479045
PNG
((R)-N-(4-(3-((5-cyclopropylpyridin-2- yl)amino)pyr...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ccc(cn1)C1CC1
Show InChI InChI=1S/C22H24N4O2/c1-2-21(27)25-18-8-5-16(6-9-18)22(28)26-12-11-19(14-26)24-20-10-7-17(13-23-20)15-3-4-15/h2,5-10,13,15,19H,1,3-4,11-12,14H2,(H,23,24)(H,25,27)/t19-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479129
PNG
((E)-N-(6-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CC[C@@H](F)C3)cn2)ncc1Cl
Show InChI InChI=1S/C23H27ClFN7O3/c1-35-21-18(24)12-27-23(30-21)29-17-7-10-32(14-17)22(34)19-5-4-16(11-26-19)28-20(33)3-2-8-31-9-6-15(25)13-31/h2-5,11-12,15,17H,6-10,13-14H2,1H3,(H,28,33)(H,27,29,30)/b3-2+/t15-,17-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479076
PNG
((R)-1-(3-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2cccc(c2)N2C(=O)C=CC2=O)nc1
Show InChI InChI=1S/C19H16ClN5O3/c20-13-9-21-19(22-10-13)23-14-6-7-24(11-14)18(28)12-2-1-3-15(8-12)25-16(26)4-5-17(25)27/h1-5,8-10,14H,6-7,11H2,(H,21,22,23)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479102
PNG
(N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C3CO3)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O4/c1-28-17-14(20)8-21-19(24-17)23-13-6-7-25(9-13)18(27)11-2-4-12(5-3-11)22-16(26)15-10-29-15/h2-5,8,13,15H,6-7,9-10H2,1H3,(H,22,26)(H,21,23,24)/t13-,15?/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479088
PNG
((R)-1-(3-(3-((5-chloro-4- (trideuteriomethoxy)pyri...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2cccc(c2)N2C(=O)C=CC2=O)ncc1Cl
Show InChI InChI=1S/C20H18ClN5O4/c1-30-18-15(21)10-22-20(24-18)23-13-7-8-25(11-13)19(29)12-3-2-4-14(9-12)26-16(27)5-6-17(26)28/h2-6,9-10,13H,7-8,11H2,1H3,(H,22,23,24)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479019
PNG
((R)-N-(4-(3-((5-fluoro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1F
Show InChI InChI=1S/C19H20FN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479003
PNG
((R)-N-(4-(3-((4-(1H-pyrazol-4- yl)pyrimidin-2-yl)a...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1nccc(n1)-c1cn[nH]c1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478993
PNG
((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cc1cc(cc(C)c1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C20H22ClN5O2/c1-4-17(27)25-18-12(2)7-14(8-13(18)3)19(28)26-6-5-16(11-26)24-20-22-9-15(21)10-23-20/h4,7-10,16H,1,5-6,11H2,2-3H3,(H,25,27)(H,22,23,24)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479067
PNG
((R)-N-(4-(3-((5-isobutylpyrimidin-2- yl)amino)pyrr...)
Show SMILES CC(C)Cc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C22H27N5O2/c1-4-20(28)25-18-7-5-17(6-8-18)21(29)27-10-9-19(14-27)26-22-23-12-16(13-24-22)11-15(2)3/h4-8,12-13,15,19H,1,9-11,14H2,2-3H3,(H,25,28)(H,23,24,26)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479081
PNG
((R,E)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)...)
Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(CNC(=O)\C=C\CN(C)C)cc2)ncc1Cl
Show InChI InChI=1S/C24H31ClN6O3/c1-4-34-22-20(25)15-27-24(29-22)28-19-11-13-31(16-19)23(33)18-9-7-17(8-10-18)14-26-21(32)6-5-12-30(2)3/h5-10,15,19H,4,11-14,16H2,1-3H3,(H,26,32)(H,27,28,29)/b6-5+/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478997
PNG
((R)-N-(4-(3-((4-methoxypyrimidin-2- yl)amino)piper...)
Show SMILES COc1ccnc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)n1
Show InChI InChI=1S/C20H23N5O3/c1-3-17(26)22-15-8-6-14(7-9-15)19(27)25-12-4-5-16(13-25)23-20-21-11-10-18(24-20)28-2/h3,6-11,16H,1,4-5,12-13H2,2H3,(H,22,26)(H,21,23,24)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479106
PNG
((R,E)-1-(6-(3-((5-chloropyrimidin-2- yl)amino)pyrr...)
Show SMILES CN(C)C\C=C\C(=O)N1CCc2ccc(cc12)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C23H27ClN6O2/c1-28(2)9-3-4-21(31)30-11-7-16-5-6-17(12-20(16)30)22(32)29-10-8-19(15-29)27-23-25-13-18(24)14-26-23/h3-6,12-14,19H,7-11,15H2,1-2H3,(H,25,26,27)/b4-3+/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479101
PNG
(N-(4-((R)-3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C3CO3)cc2)nc1
Show InChI InChI=1S/C18H18ClN5O3/c19-12-7-20-18(21-8-12)23-14-5-6-24(9-14)17(26)11-1-3-13(4-2-11)22-16(25)15-10-27-15/h1-4,7-8,14-15H,5-6,9-10H2,(H,22,25)(H,20,21,23)/t14-,15?/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479058
PNG
((R,E)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrr...)
Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN6O2/c1-27(2)10-3-4-19(29)25-17-7-5-15(6-8-17)20(30)28-11-9-18(14-28)26-21-23-12-16(22)13-24-21/h3-8,12-13,18H,9-11,14H2,1-2H3,(H,25,29)(H,23,24,26)/b4-3+/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479035
PNG
((R)-N-(4-(3-((5-methylpyridin-2- yl)amino)pyrrolid...)
Show SMILES Cc1ccc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C20H22N4O2/c1-3-19(25)23-16-7-5-15(6-8-16)20(26)24-11-10-17(13-24)22-18-9-4-14(2)12-21-18/h3-9,12,17H,1,10-11,13H2,2H3,(H,21,22)(H,23,25)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479021
PNG
((R)-N-(4-(3-((5-methylpyrazin-2- yl)amino)pyrrolid...)
Show SMILES Cc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)cn1
Show InChI InChI=1S/C19H21N5O2/c1-3-18(25)23-15-6-4-14(5-7-15)19(26)24-9-8-16(12-24)22-17-11-20-13(2)10-21-17/h3-7,10-11,16H,1,8-9,12H2,2H3,(H,21,22)(H,23,25)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478976
PNG
((R)-N-(4-(3-((4-cyclopropoxy-5- methylpyrimidin-2-...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(C)c(OC2CC2)n1
Show InChI InChI=1S/C22H27N5O3/c1-3-19(28)24-16-6-4-15(5-7-16)21(29)27-11-10-17(13-27)25-22-23-12-14(2)20(26-22)30-18-8-9-18/h4-7,12,17-18H,3,8-11,13H2,1-2H3,(H,24,28)(H,23,25,26)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479092
PNG
((R)-1-(6-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3CN(CCc3c2)C(=O)C=C)nc1
Show InChI InChI=1S/C21H22ClN5O2/c1-2-19(28)26-7-5-14-9-15(3-4-16(14)12-26)20(29)27-8-6-18(13-27)25-21-23-10-17(22)11-24-21/h2-4,9-11,18H,1,5-8,12-13H2,(H,23,24,25)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479006
PNG
((R)-N-(4-(3-((4-((1-methyl-1H- pyrazol-4-yl)oxy)py...)
Show SMILES Cn1cc(Oc2ccnc(N[C@@H]3CCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)n2)cn1
Show InChI InChI=1S/C22H23N7O3/c1-3-19(30)25-16-6-4-15(5-7-16)21(31)29-11-9-17(13-29)26-22-23-10-8-20(27-22)32-18-12-24-28(2)14-18/h3-8,10,12,14,17H,1,9,11,13H2,2H3,(H,25,30)(H,23,26,27)/t17-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479070
PNG
((R)-N-(3-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Cn1nc(cc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C16H18ClN7O2/c1-3-14(25)21-13-6-12(22-23(13)2)15(26)24-5-4-11(9-24)20-16-18-7-10(17)8-19-16/h3,6-8,11H,1,4-5,9H2,2H3,(H,21,25)(H,18,19,20)/t11-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479095
PNG
((R)-N-(3-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES CN(C)\C=C(/C#N)C(=O)Nc1cccc(c1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C21H22ClN7O2/c1-28(2)12-15(9-23)19(30)26-17-5-3-4-14(8-17)20(31)29-7-6-18(13-29)27-21-24-10-16(22)11-25-21/h3-5,8,10-12,18H,6-7,13H2,1-2H3,(H,26,30)(H,24,25,27)/b15-12+/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479100
PNG
((R)-1-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(cc2)N2C(=O)C=CC2=O)nc1
Show InChI InChI=1S/C19H16ClN5O3/c20-13-9-21-19(22-10-13)23-14-7-8-24(11-14)18(28)12-1-3-15(4-2-12)25-16(26)5-6-17(25)27/h1-6,9-10,14H,7-8,11H2,(H,21,22,23)/t14-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479109
PNG
((R,E)-1-(6-(3-((5-chloropyrimidin-2- yl)amino)pyrr...)
Show SMILES CN(C)C\C=C\C(=O)N1CCc2cc(ccc2C1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C24H29ClN6O2/c1-29(2)9-3-4-22(32)30-10-7-17-12-18(5-6-19(17)15-30)23(33)31-11-8-21(16-31)28-24-26-13-20(25)14-27-24/h3-6,12-14,21H,7-11,15-16H2,1-2H3,(H,26,27,28)/b4-3+/t21-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479119
PNG
((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Show SMILES CN(C)CCN(C)c1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1
Show InChI InChI=1S/C23H30BrN7O2/c1-5-21(32)28-19-7-6-16(12-20(19)30(4)11-10-29(2)3)22(33)31-9-8-18(15-31)27-23-25-13-17(24)14-26-23/h5-7,12-14,18H,1,8-11,15H2,2-4H3,(H,28,32)(H,25,26,27)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478973
PNG
((R)-N-(4-(3-((4-cyclopropoxy-5- fluoropyrimidin-2-...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(F)c(OC2CC2)n1
Show InChI InChI=1S/C21H24FN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h3-6,11,15-16H,2,7-10,12H2,1H3,(H,24,28)(H,23,25,26)/t15-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478996
PNG
((R)-N-(4-(3-((4- morpholinopyrimidin-2- yl)amino)p...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1nccc(n1)N1CCOCC1
Show InChI InChI=1S/C23H28N6O3/c1-2-21(30)25-18-7-5-17(6-8-18)22(31)29-11-3-4-19(16-29)26-23-24-10-9-20(27-23)28-12-14-32-15-13-28/h2,5-10,19H,1,3-4,11-16H2,(H,25,30)(H,24,26,27)/t19-/m1/s1
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n/an/a 5.01E+4n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479068
PNG
((S)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)-3-met...)
Show SMILES C[C@@]1(CCN(C1)C(=O)c1ccc(NC(=O)C=C)cc1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-3-16(26)23-15-6-4-13(5-7-15)17(27)25-9-8-19(2,12-25)24-18-21-10-14(20)11-22-18/h3-7,10-11H,1,8-9,12H2,2H3,(H,23,26)(H,21,22,24)/t19-/m0/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479057
PNG
((R)-N-(4-(3-((5-chloro-4- hydroxypyrimidin-2- yl)a...)
Show SMILES Oc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl
Show InChI InChI=1S/C18H18ClN5O3/c1-2-15(25)21-12-5-3-11(4-6-12)17(27)24-8-7-13(10-24)22-18-20-9-14(19)16(26)23-18/h2-6,9,13H,1,7-8,10H2,(H,21,25)(H2,20,22,23,26)/t13-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478995
PNG
((R)-N-(4-(3-((4-(1-methyl-1H- pyrazol-5-yl)pyrimid...)
Show SMILES Cn1nccc1-c1ccnc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)n1
Show InChI InChI=1S/C23H25N7O2/c1-3-21(31)26-17-8-6-16(7-9-17)22(32)30-14-4-5-18(15-30)27-23-24-12-10-19(28-23)20-11-13-25-29(20)2/h3,6-13,18H,1,4-5,14-15H2,2H3,(H,26,31)(H,24,27,28)/t18-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479001
PNG
((R)-N-(4-(3-((4-(1H-pyrazol-4- yl)pyrimidin-2-yl)a...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1nccc(n1)-c1cn[nH]c1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479002
PNG
((R)-N-(4-(3-((4- morpholinopyrimidin-2- yl)amino)p...)
Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1nccc(n1)N1CCOCC1
Show InChI InChI=1S/C23H30N6O3/c1-2-21(30)25-18-7-5-17(6-8-18)22(31)29-11-3-4-19(16-29)26-23-24-10-9-20(27-23)28-12-14-32-15-13-28/h5-10,19H,2-4,11-16H2,1H3,(H,25,30)(H,24,26,27)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478999
PNG
((R)-N-(4-(3-((4-(1-methyl-1H- pyrazol-4-yl)pyrimid...)
Show SMILES Cn1cc(cn1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)n1
Show InChI InChI=1S/C23H25N7O2/c1-3-21(31)26-18-8-6-16(7-9-18)22(32)30-12-4-5-19(15-30)27-23-24-11-10-20(28-23)17-13-25-29(2)14-17/h3,6-11,13-14,19H,1,4-5,12,15H2,2H3,(H,26,31)(H,24,27,28)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM478998
PNG
((R)-N-(4-(3-((5-chloropyrazin-2- yl)amino)piperidi...)
Show SMILES Clc1cnc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-2-18(26)24-14-7-5-13(6-8-14)19(27)25-9-3-4-15(12-25)23-17-11-21-16(20)10-22-17/h2,5-8,10-11,15H,1,3-4,9,12H2,(H,22,23)(H,24,26)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479082
PNG
((R,E)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrr...)
Show SMILES CN(C)C\C=C\C(=O)NCc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C22H27ClN6O2/c1-28(2)10-3-4-20(30)24-12-16-5-7-17(8-6-16)21(31)29-11-9-19(15-29)27-22-25-13-18(23)14-26-22/h3-8,13-14,19H,9-12,15H2,1-2H3,(H,24,30)(H,25,26,27)/b4-3+/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479120
PNG
((R)-N-(4-(3-((5-cyano-4- methoxypyrimidin-2- yl)am...)
Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C#N
Show InChI InChI=1S/C20H20N6O3/c1-3-17(27)23-15-6-4-13(5-7-15)19(28)26-9-8-16(12-26)24-20-22-11-14(10-21)18(25-20)29-2/h3-7,11,16H,1,8-9,12H2,2H3,(H,23,27)(H,22,24,25)/t16-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479115
PNG
((S)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Show SMILES Clc1cnc(N[C@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1
Show InChI InChI=1S/C18H18ClN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h2-6,9-10,15H,1,7-8,11H2,(H,22,25)(H,20,21,23)/t15-/m0/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479069
PNG
((R)-N-(4-(3-((5-cyanopyrimidin-2- yl)amino)pyrroli...)
Show SMILES C[C@]1(CCN(C1)C(=O)c1ccc(NC(=O)C=C)cc1)Nc1ncc(Cl)cn1
Show InChI InChI=1S/C19H20ClN5O2/c1-3-16(26)23-15-6-4-13(5-7-15)17(27)25-9-8-19(2,12-25)24-18-21-10-14(20)11-22-18/h3-7,10-11H,1,8-9,12H2,2H3,(H,23,26)(H,21,22,24)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479000
PNG
((R)-N-(4-(3-((4- (cyclopentyloxy)pyrimidin-2- yl)a...)
Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1nccc(OC2CCCC2)n1
Show InChI InChI=1S/C24H29N5O3/c1-2-21(30)26-18-11-9-17(10-12-18)23(31)29-15-5-6-19(16-29)27-24-25-14-13-22(28-24)32-20-7-3-4-8-20/h2,9-14,19-20H,1,3-8,15-16H2,(H,26,30)(H,25,27,28)/t19-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479066
PNG
((R)-N-(3-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Show SMILES COc1nc(N[C@@H]2CCCN(C2)C(=O)c2cccc(NC(=O)C=C)c2)ncc1Cl
Show InChI InChI=1S/C20H22ClN5O3/c1-3-17(27)23-14-7-4-6-13(10-14)19(28)26-9-5-8-15(12-26)24-20-22-11-16(21)18(25-20)29-2/h3-4,6-7,10-11,15H,1,5,8-9,12H2,2H3,(H,23,27)(H,22,24,25)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 12


(Homo sapiens)
BDBM479078
PNG
((R)-N-(4-(3-((4-(dimethylamino)-5- (trifluoromethy...)
Show SMILES CN(C)c1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O2/c1-4-17(31)26-14-7-5-13(6-8-14)19(32)30-10-9-15(12-30)27-20-25-11-16(21(22,23)24)18(28-20)29(2)3/h4-8,11,15H,1,9-10,12H2,2-3H3,(H,26,31)(H,25,27,28)/t15-/m1/s1
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KINNATE BIOPHARMA INC.

US Patent


Assay Description
The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...


US Patent US10894788 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%