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Patent code US10894789

Compile Data Set for Download or QSAR

Found 334 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479267
PNG
(US10894789, Compound 66)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccc1F
Show InChI InChI=1S/C23H21F6N5OS/c1-12-7-22(25,26)11-34(17(12)10-32-21-30-8-14(9-31-21)23(27,28)29)20(35)18-19(36-13(2)33-18)15-5-3-4-6-16(15)24/h3-6,8-9,12,17H,7,10-11H2,1-2H3,(H,30,31,32)/t12-,17?/m1/s1
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n/an/a 1n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479289
PNG
(US10894789, Compound 233)
Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)c(C)c1-c1ncccn1
Show InChI InChI=1S/C22H23F5N8O/c1-12-7-21(23,24)11-35(15(12)10-32-20-30-8-14(9-31-20)22(25,26)27)19(36)17-16(13(2)34(3)33-17)18-28-5-4-6-29-18/h4-6,8-9,12,15H,7,10-11H2,1-3H3,(H,30,31,32)/t12-,15-/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479169
PNG
(US10894789, Compound 125)
Show SMILES COc1ccc(cc1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(18(14)9-31-20-11-30-19(10-32-20)24(27,28)29)22(36)21-17(12-34(2)33-21)15-4-6-16(37-3)7-5-15/h4-7,10-12,14,18H,8-9,13H2,1-3H3,(H,31,32)/t14-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479203
PNG
(US10894789, Compound 78)
Show SMILES COc1ccc(nc1)-c1sc(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H23F5N6O2S/c1-12-6-22(24,25)11-34(17(12)10-32-21-30-7-14(8-31-21)23(26,27)28)20(35)18-19(37-13(2)33-18)16-5-4-15(36-3)9-29-16/h4-5,7-9,12,17H,6,10-11H2,1-3H3,(H,30,31,32)/t12-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479230
PNG
(US10894789, Compound 21)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccc1
Show InChI InChI=1S/C23H23F5N6O/c1-14-8-22(24,25)13-34(18(14)11-31-21-29-9-16(10-30-21)23(26,27)28)20(35)19-17(12-33(2)32-19)15-6-4-3-5-7-15/h3-7,9-10,12,14,18H,8,11,13H2,1-2H3,(H,29,30,31)/t14-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479243
PNG
(US10894789, Compound 169)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C24H23F6N5O/c1-14-9-23(26,27)13-35(19(14)11-32-20-8-5-16(10-31-20)24(28,29)30)22(36)21-18(12-34(2)33-21)15-3-6-17(25)7-4-15/h3-8,10,12,14,19H,9,11,13H2,1-2H3,(H,31,32)/t14-,19?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479229
PNG
(US10894789, Compound 120)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccc1
Show InChI InChI=1S/C23H23F5N6O/c1-14-8-22(24,25)13-34(17(14)9-30-19-11-29-18(10-31-19)23(26,27)28)21(35)20-16(12-33(2)32-20)15-6-4-3-5-7-15/h3-7,10-12,14,17H,8-9,13H2,1-2H3,(H,30,31)/t14-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479282
PNG
(US10894789, Compound 221)
Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(Cl)cn1
Show InChI InChI=1S/C22H21ClF5N7O/c1-12-5-21(24,25)11-35(17(12)9-32-20-30-6-13(7-31-20)22(26,27)28)19(36)18-15(10-34(2)33-18)16-4-3-14(23)8-29-16/h3-4,6-8,10,12,17H,5,9,11H2,1-2H3,(H,30,31,32)/t12-,17-/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479241
PNG
(US10894789, Compound 185)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1
Show InChI InChI=1S/C24H22F6N4OS/c1-13-9-23(26,27)12-34(18(13)11-32-19-8-5-16(10-31-19)24(28,29)30)22(35)20-21(36-14(2)33-20)15-3-6-17(25)7-4-15/h3-8,10,13,18H,9,11-12H2,1-2H3,(H,31,32)/t13-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479176
PNG
(US10894789, Compound 123)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1cccc(C)c1
Show InChI InChI=1S/C24H25F5N6O/c1-14-5-4-6-16(7-14)17-12-34(3)33-21(17)22(36)35-13-23(25,26)8-15(2)18(35)9-31-20-11-30-19(10-32-20)24(27,28)29/h4-7,10-12,15,18H,8-9,13H2,1-3H3,(H,31,32)/t15-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479227
PNG
(US10894789, Compound 211)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccn1
Show InChI InChI=1S/C22H21F5N6OS/c1-12-7-21(23,24)11-33(15(12)8-30-17-10-29-16(9-31-17)22(25,26)27)20(34)18-19(35-13(2)32-18)14-5-3-4-6-28-14/h3-6,9-10,12,15H,7-8,11H2,1-2H3,(H,30,31)/t12-,15?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479268
PNG
(US10894789, Compound 65)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccc1
Show InChI InChI=1S/C23H22F5N5OS/c1-13-8-22(24,25)12-33(17(13)11-31-21-29-9-16(10-30-21)23(26,27)28)20(34)18-19(35-14(2)32-18)15-6-4-3-5-7-15/h3-7,9-10,13,17H,8,11-12H2,1-2H3,(H,29,30,31)/t13-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479201
PNG
(US10894789, Compound 150)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cc(F)ccn1
Show InChI InChI=1S/C22H20F6N6OS/c1-11-6-21(24,25)10-34(15(11)7-31-17-9-30-16(8-32-17)22(26,27)28)20(35)18-19(36-12(2)33-18)14-5-13(23)3-4-29-14/h3-5,8-9,11,15H,6-7,10H2,1-2H3,(H,31,32)/t11-,15?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479239
PNG
(US10894789, Compound 30)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C23H22F6N6O/c1-13-7-22(25,26)12-35(18(13)10-32-21-30-8-15(9-31-21)23(27,28)29)20(36)19-17(11-34(2)33-19)14-3-5-16(24)6-4-14/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,30,31,32)/t13-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479308
PNG
(US10894789, Compound 264)
Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)c(C)c1-c1ncc(F)cn1
Show InChI InChI=1S/C22H22F6N8O/c1-11-4-21(24,25)10-36(15(11)9-33-20-31-5-13(6-32-20)22(26,27)28)19(37)17-16(12(2)35(3)34-17)18-29-7-14(23)8-30-18/h5-8,11,15H,4,9-10H2,1-3H3,(H,31,32,33)/t11-,15-/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479157
PNG
(US10894789, Compound 197)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(C)cn1
Show InChI InChI=1S/C24H24F5N5OS/c1-13-4-6-17(30-9-13)21-20(33-15(3)36-21)22(35)34-12-23(25,26)8-14(2)18(34)11-32-19-7-5-16(10-31-19)24(27,28)29/h4-7,9-10,14,18H,8,11-12H2,1-3H3,(H,31,32)/t14-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479174
PNG
(US10894789, Compound 63)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cccc(C)c1
Show InChI InChI=1S/C24H24F5N5OS/c1-13-5-4-6-16(7-13)20-19(33-15(3)36-20)21(35)34-12-23(25,26)8-14(2)18(34)11-32-22-30-9-17(10-31-22)24(27,28)29/h4-7,9-10,14,18H,8,11-12H2,1-3H3,(H,30,31,32)/t14-,18?/m1/s1
PDB

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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479190
PNG
(US10894789, Compound 23)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccc1F
Show InChI InChI=1S/C23H22F6N6O/c1-13-7-22(25,26)12-35(18(13)10-32-21-30-8-14(9-31-21)23(27,28)29)20(36)19-16(11-34(2)33-19)15-5-3-4-6-17(15)24/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,30,31,32)/t13-,18?/m1/s1
PDB

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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479151
PNG
(US10894789, Compound 33)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClF5N6O/c1-13-7-22(25,26)12-35(18(13)10-32-21-30-8-15(9-31-21)23(27,28)29)20(36)19-17(11-34(2)33-19)14-3-5-16(24)6-4-14/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,30,31,32)/t13-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479169
PNG
(US10894789, Compound 125)
Show SMILES COc1ccc(cc1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(18(14)9-31-20-11-30-19(10-32-20)24(27,28)29)22(36)21-17(12-34(2)33-21)15-4-6-16(37-3)7-5-15/h4-7,10-12,14,18H,8-9,13H2,1-3H3,(H,31,32)/t14-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479202
PNG
(US10894789, Compound 77)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cccc(C)n1
Show InChI InChI=1S/C23H23F5N6OS/c1-12-7-22(24,25)11-34(17(12)10-31-21-29-8-15(9-30-21)23(26,27)28)20(35)18-19(36-14(3)33-18)16-6-4-5-13(2)32-16/h4-6,8-9,12,17H,7,10-11H2,1-3H3,(H,29,30,31)/t12-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479144
PNG
(US10894789, Compound 200)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ncccn1
Show InChI InChI=1S/C22H22F5N7O/c1-13-8-21(23,24)12-34(16(13)10-31-17-5-4-14(9-30-17)22(25,26)27)20(35)18-15(11-33(2)32-18)19-28-6-3-7-29-19/h3-7,9,11,13,16H,8,10,12H2,1-2H3,(H,30,31)/t13-,16?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479175
PNG
(US10894789, Compound 134)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1cc(C)ccn1
Show InChI InChI=1S/C23H24F5N7O/c1-13-4-5-29-16(6-13)15-11-34(3)33-20(15)21(36)35-12-22(24,25)7-14(2)17(35)8-31-19-10-30-18(9-32-19)23(26,27)28/h4-6,9-11,14,17H,7-8,12H2,1-3H3,(H,31,32)/t14-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479273
PNG
(US10894789, Compound 217)
Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ncc(F)cn1
Show InChI InChI=1S/C21H20F6N8O/c1-11-3-20(23,24)10-35(15(11)8-32-19-30-4-12(5-31-19)21(25,26)27)18(36)16-14(9-34(2)33-16)17-28-6-13(22)7-29-17/h4-7,9,11,15H,3,8,10H2,1-2H3,(H,30,31,32)/t11-,15-/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479150
PNG
(Compound 185: ((2S,3R)-5,5-difluoro-3-methyl-2-(((...)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClF5N6O/c1-13-7-22(25,26)12-35(17(13)8-31-19-10-30-18(9-32-19)23(27,28)29)21(36)20-16(11-34(2)33-20)14-3-5-15(24)6-4-14/h3-6,9-11,13,17H,7-8,12H2,1-2H3,(H,31,32)/t13-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479168
PNG
(US10894789, Compound 124)
Show SMILES COc1cccc(c1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(18(14)9-31-20-11-30-19(10-32-20)24(27,28)29)22(36)21-17(12-34(2)33-21)15-5-4-6-16(7-15)37-3/h4-7,10-12,14,18H,8-9,13H2,1-3H3,(H,31,32)/t14-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479178
PNG
(US10894789, Compound 64)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(C)cc1
Show InChI InChI=1S/C24H24F5N5OS/c1-13-4-6-16(7-5-13)20-19(33-15(3)36-20)21(35)34-12-23(25,26)8-14(2)18(34)11-32-22-30-9-17(10-31-22)24(27,28)29/h4-7,9-10,14,18H,8,11-12H2,1-3H3,(H,30,31,32)/t14-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479191
PNG
(US10894789, Compound 25)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1cccc(F)c1
Show InChI InChI=1S/C23H22F6N6O/c1-13-7-22(25,26)12-35(18(13)10-32-21-30-8-15(9-31-21)23(27,28)29)20(36)19-17(11-34(2)33-19)14-4-3-5-16(24)6-14/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,30,31,32)/t13-,18?/m1/s1
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n/an/a 4n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479159
PNG
(US10894789, Compound 174)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1
Show InChI InChI=1S/C22H22F5N7O/c1-13-9-21(23,24)12-33(17(13)11-29-18-6-4-15(10-28-18)22(25,26)27)20(35)19-16(5-3-14(2)32-19)34-30-7-8-31-34/h3-8,10,13,17H,9,11-12H2,1-2H3,(H,28,29)/t13-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479198
PNG
(US10894789, Compound 142)
Show SMILES COc1cccc(c1)-c1sc(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H24F5N5O2S/c1-13-8-23(25,26)12-34(17(13)9-31-19-11-30-18(10-32-19)24(27,28)29)22(35)20-21(37-14(2)33-20)15-5-4-6-16(7-15)36-3/h4-7,10-11,13,17H,8-9,12H2,1-3H3,(H,31,32)/t13-,17?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479158
PNG
(US10894789, Compound 175)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(C)cc1
Show InChI InChI=1S/C25H26F5N5O/c1-15-4-6-17(7-5-15)19-13-34(3)33-22(19)23(36)35-14-24(26,27)10-16(2)20(35)12-32-21-9-8-18(11-31-21)25(28,29)30/h4-9,11,13,16,20H,10,12,14H2,1-3H3,(H,31,32)/t16-,20?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479165
PNG
(US10894789, Compound 29)
Show SMILES COc1cccc(c1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(19(14)11-32-22-30-9-16(10-31-22)24(27,28)29)21(36)20-18(12-34(2)33-20)15-5-4-6-17(7-15)37-3/h4-7,9-10,12,14,19H,8,11,13H2,1-3H3,(H,30,31,32)/t14-,19?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479185
PNG
(US10894789, Compound 26)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1cccc(C)c1
Show InChI InChI=1S/C24H25F5N6O/c1-14-5-4-6-16(7-14)18-12-34(3)33-20(18)21(36)35-13-23(25,26)8-15(2)19(35)11-32-22-30-9-17(10-31-22)24(27,28)29/h4-7,9-10,12,15,19H,8,11,13H2,1-3H3,(H,30,31,32)/t15-,19?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479238
PNG
(US10894789, Compound 31)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(Cl)cn1)C(=O)c1nn(C)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C22H22ClF3N6O/c1-13-7-22(25,26)12-32(18(13)10-29-21-27-8-15(23)9-28-21)20(33)19-17(11-31(2)30-19)14-3-5-16(24)6-4-14/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,27,28,29)/t13-,18?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479252
PNG
(US10894789, Compound 51)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ccccc1
Show InChI InChI=1S/C25H24F5N5O/c1-15-10-24(26,27)14-35(20(15)13-33-23-31-11-18(12-32-23)25(28,29)30)22(36)21-19(9-8-16(2)34-21)17-6-4-3-5-7-17/h3-9,11-12,15,20H,10,13-14H2,1-2H3,(H,31,32,33)/t15-,20?/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479272
PNG
(US10894789, Compound 216)
Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1COc1ccc(cn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-c1nnn(C)n1
Show InChI InChI=1S/C22H20ClF5N6O2/c1-12-8-21(24,25)11-34(17(12)10-36-18-6-3-13(9-29-18)22(26,27)28)20(35)16-7-14(23)4-5-15(16)19-30-32-33(2)31-19/h3-7,9,12,17H,8,10-11H2,1-2H3/t12-,17-/m1/s1
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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479161
PNG
(US10894789, Compound 147)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cc(C)ccn1
Show InChI InChI=1S/C23H23F5N6OS/c1-12-4-5-29-15(6-12)20-19(33-14(3)36-20)21(35)34-11-22(24,25)7-13(2)16(34)8-31-18-10-30-17(9-32-18)23(26,27)28/h4-6,9-10,13,16H,7-8,11H2,1-3H3,(H,31,32)/t13-,16?/m1/s1
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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479192
PNG
(US10894789, Compound 121)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C23H22F6N6O/c1-13-7-22(25,26)12-35(17(13)8-31-19-10-30-18(9-32-19)23(27,28)29)21(36)20-16(11-34(2)33-20)14-3-5-15(24)6-4-14/h3-6,9-11,13,17H,7-8,12H2,1-2H3,(H,31,32)/t13-,17?/m1/s1
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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479266
PNG
(US10894789, Compound 67)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cccc(F)c1
Show InChI InChI=1S/C23H21F6N5OS/c1-12-7-22(25,26)11-34(17(12)10-32-21-30-8-15(9-31-21)23(27,28)29)20(35)18-19(36-13(2)33-18)14-4-3-5-16(24)6-14/h3-6,8-9,12,17H,7,10-11H2,1-2H3,(H,30,31,32)/t12-,17?/m1/s1
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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479297
PNG
(US10894789, Compound 242)
Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cc1F)C(F)(F)F)C(=O)c1nn(C)cc1-c1ncc(F)cn1
Show InChI InChI=1S/C22H20F7N7O/c1-11-4-21(25,26)10-36(16(11)8-33-19-15(24)3-12(5-30-19)22(27,28)29)20(37)17-14(9-35(2)34-17)18-31-6-13(23)7-32-18/h3,5-7,9,11,16H,4,8,10H2,1-2H3,(H,30,33)/t11-,16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479172
PNG
(US10894789, Compound 137)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1
Show InChI InChI=1S/C23H21F6N5OS/c1-12-7-22(25,26)11-34(16(12)8-31-18-10-30-17(9-32-18)23(27,28)29)21(35)19-20(36-13(2)33-19)14-3-5-15(24)6-4-14/h3-6,9-10,12,16H,7-8,11H2,1-2H3,(H,31,32)/t12-,16?/m1/s1
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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479197
PNG
(US10894789, Compound 167)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccn1
Show InChI InChI=1S/C23H23F5N6O/c1-14-9-22(24,25)13-34(18(14)11-31-19-7-6-15(10-30-19)23(26,27)28)21(35)20-16(12-33(2)32-20)17-5-3-4-8-29-17/h3-8,10,12,14,18H,9,11,13H2,1-2H3,(H,30,31)/t14-,18?/m1/s1
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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479237
PNG
(US10894789, Compound 70)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccn1
Show InChI InChI=1S/C22H21F5N6OS/c1-12-7-21(23,24)11-33(16(12)10-31-20-29-8-14(9-30-20)22(25,26)27)19(34)17-18(35-13(2)32-17)15-5-3-4-6-28-15/h3-6,8-9,12,16H,7,10-11H2,1-2H3,(H,29,30,31)/t12-,16?/m1/s1
PDB

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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479179
PNG
(US10894789, Compound 122)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(C)cc1
Show InChI InChI=1S/C24H25F5N6O/c1-14-4-6-16(7-5-14)17-12-34(3)33-21(17)22(36)35-13-23(25,26)8-15(2)18(35)9-31-20-11-30-19(10-32-20)24(27,28)29/h4-7,10-12,15,18H,8-9,13H2,1-3H3,(H,31,32)/t15-,18?/m1/s1
PDB

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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479271
PNG
(US10894789, Compound 215)
Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1COc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1
Show InChI InChI=1S/C24H22F5N5O2/c1-14-10-23(25,26)13-34(18(14)12-36-19-7-5-16(11-32-19)24(27,28)29)22(35)20-17(6-4-15(2)33-20)21-30-8-3-9-31-21/h3-9,11,14,18H,10,12-13H2,1-2H3/t14-,18-/m1/s1
PDB

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n/an/a 5n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479228
PNG
(US10894789, Compound 130)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccn1
Show InChI InChI=1S/C22H22F5N7O/c1-13-7-21(23,24)12-34(16(13)8-30-18-10-29-17(9-31-18)22(25,26)27)20(35)19-14(11-33(2)32-19)15-5-3-4-6-28-15/h3-6,9-11,13,16H,7-8,12H2,1-2H3,(H,30,31)/t13-,16?/m1/s1
PDB

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n/an/a 6n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479265
PNG
(US10894789, Compound 49)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ncccn1
Show InChI InChI=1S/C21H20F5N7OS/c1-11-6-20(22,23)10-33(14(11)9-31-19-29-7-13(8-30-19)21(24,25)26)18(34)15-16(35-12(2)32-15)17-27-4-3-5-28-17/h3-5,7-8,11,14H,6,9-10H2,1-2H3,(H,29,30,31)/t11-,14?/m1/s1
PDB

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n/an/a 6n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479162
PNG
(US10894789, Compound 148)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(C)cn1
Show InChI InChI=1S/C23H23F5N6OS/c1-12-4-5-15(29-7-12)20-19(33-14(3)36-20)21(35)34-11-22(24,25)6-13(2)16(34)8-31-18-10-30-17(9-32-18)23(26,27)28/h4-5,7,9-10,13,16H,6,8,11H2,1-3H3,(H,31,32)/t13-,16?/m1/s1
PDB

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n/an/a 6n/an/an/an/an/an/a



ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479199
PNG
(US10894789, Compound 141)
Show SMILES COc1ccc(cc1)-c1sc(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H24F5N5O2S/c1-13-8-23(25,26)12-34(17(13)9-31-19-11-30-18(10-32-19)24(27,28)29)22(35)20-21(37-14(2)33-20)15-4-6-16(36-3)7-5-15/h4-7,10-11,13,17H,8-9,12H2,1-3H3,(H,31,32)/t13-,17?/m1/s1
PDB

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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM479171
PNG
(US10894789, Compound 138)
Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(C)cc1
Show InChI InChI=1S/C24H24F5N5OS/c1-13-4-6-16(7-5-13)21-20(33-15(3)36-21)22(35)34-12-23(25,26)8-14(2)17(34)9-31-19-11-30-18(10-32-19)24(27,28)29/h4-7,10-11,14,17H,8-9,12H2,1-3H3,(H,31,32)/t14-,17?/m1/s1
PDB

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ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...


US Patent US10894789 (2021)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 334 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%