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Patent code US10899753

Compile Data Set for Download or QSAR
Found 110 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480080
PNG
(3-(tert-butyl)-N-(4-(4-((1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C22H22F3N9O2/c1-21(2,3)19-32-18(36-33-19)17(35)26-8-13-6-5-12(7-15(13)22(23,24)25)16-27-11-28-20(31-16)30-14-9-29-34(4)10-14/h5-7,9-11H,8H2,1-4H3,(H,26,35)(H,27,28,30,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480359
PNG
(5-(tert-butyl)-N-(2-chloro-3-fluoro-4-(4-((1-methy...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(Cl)c2F)cn1
Show InChI InChI=1S/C21H21ClFN9O2/c1-21(2,3)19-29-17(31-34-19)18(33)24-7-11-5-6-13(15(23)14(11)22)16-25-10-26-20(30-16)28-12-8-27-32(4)9-12/h5-6,8-10H,7H2,1-4H3,(H,24,33)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480361
PNG
(N-(2-chloro-3-fluoro-4-(4-((1-methyl-1H-pyrazol-4-...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C3(C)CC3)c(Cl)c2F)cn1
Show InChI InChI=1S/C21H19ClFN9O2/c1-21(5-6-21)19-29-17(31-34-19)18(33)24-7-11-3-4-13(15(23)14(11)22)16-25-10-26-20(30-16)28-12-8-27-32(2)9-12/h3-4,8-10H,5-7H2,1-2H3,(H,24,33)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480366
PNG
(2-tert-butyl-N-[(5R)-2-[4-[(1-methylpyrazol-4-yl)a...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2)NC(=O)c2cnc(o2)C(C)(C)C)cn1
Show InChI InChI=1S/C26H30N8O2/c1-26(2,3)24-27-13-21(36-24)23(35)32-20-8-6-5-7-16-11-17(9-10-19(16)20)22-28-15-29-25(33-22)31-18-12-30-34(4)14-18/h9-15,20H,5-8H2,1-4H3,(H,32,35)(H,28,29,31,33)/t20-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480367
PNG
(1-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2cnn(c2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26FN9O/c1-14-15(8-25-21(34)16-9-29-33(11-16)23(2,3)4)6-7-18(19(14)24)20-26-13-27-22(31-20)30-17-10-28-32(5)12-17/h6-7,9-13H,8H2,1-5H3,(H,25,34)(H,26,27,30,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480375
PNG
(US10899753, Example 48)
Show SMILES Cc1cc(ccc1CNC(=O)c1nc(no1)C1(CF)CC1)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H22FN9O2/c1-13-7-14(17-25-12-26-21(29-17)28-16-9-27-32(2)10-16)3-4-15(13)8-24-18(33)19-30-20(31-34-19)22(11-23)5-6-22/h3-4,7,9-10,12H,5-6,8,11H2,1-2H3,(H,24,33)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480376
PNG
(US10899753, Example 49)
Show SMILES Cc1cc(ccc1CNC(=O)c1noc(n1)C1(CF)CC1)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H22FN9O2/c1-13-7-14(17-25-12-26-21(30-17)28-16-9-27-32(2)10-16)3-4-15(13)8-24-19(33)18-29-20(34-31-18)22(11-23)5-6-22/h3-4,7,9-10,12H,5-6,8,11H2,1-2H3,(H,24,33)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480386
PNG
(N-(5-fluoro-2-methyl-4-(4-((1-methyl-1H-pyrazol-4-...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1nc(no1)C1(CF)CC1)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H21F2N9O2/c1-12-5-15(17-26-11-27-21(30-17)29-14-8-28-33(2)9-14)16(24)6-13(12)7-25-18(34)19-31-20(32-35-19)22(10-23)3-4-22/h5-6,8-9,11H,3-4,7,10H2,1-2H3,(H,25,34)(H,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480392
PNG
((R)-5-(tert-butyl)-N-(1-(3-fluoro-2-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(F)c1C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H26FN9O2/c1-12-14(13(2)27-20(34)19-29-21(35-32-19)23(3,4)5)7-8-15(17(12)24)18-25-11-26-22(30-18)28-16-9-10-33(6)31-16/h7-11,13H,1-6H3,(H,27,34)(H,25,26,28,30,31)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480396
PNG
(Synthesis of (R)-3-(tert-butyl)-N-(1-(3-fluoro-2-m...)
Show SMILES C[C@@H](NC(=O)c1cc(no1)C(C)(C)C)c1ccc(c(F)c1C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C24H27FN8O2/c1-13-16(14(2)29-22(34)18-9-19(32-35-18)24(3,4)5)7-8-17(20(13)25)21-26-12-27-23(31-21)30-15-10-28-33(6)11-15/h7-12,14H,1-6H3,(H,29,34)(H,26,27,30,31)/t14-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480397
PNG
(Synthesis of (R)-5-(tert-butyl)-N-(1-(3-fluoro-2-m...)
Show SMILES C[C@@H](NC(=O)c1cc(on1)C(C)(C)C)c1ccc(c(F)c1C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C24H27FN8O2/c1-13-16(14(2)29-22(34)18-9-19(35-32-18)24(3,4)5)7-8-17(20(13)25)21-26-12-27-23(31-21)30-15-10-28-33(6)11-15/h7-12,14H,1-6H3,(H,29,34)(H,26,27,30,31)/t14-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480407
PNG
((R)-5-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(CC(F)(F)F)Cc3c2)NC(=O)c2noc(n2)C(C)(C)C)cn1
Show InChI InChI=1S/C26H29F3N10O2/c1-25(2,3)23-35-21(37-41-23)22(40)34-19-7-8-39(13-26(27,28)29)11-16-9-15(5-6-18(16)19)20-30-14-31-24(36-20)33-17-10-32-38(4)12-17/h5-6,9-10,12,14,19H,7-8,11,13H2,1-4H3,(H,34,40)(H,30,31,33,36)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480418
PNG
(N-(2-chloro-3-fluoro-4-(4-((1-methyl-1H-pyrazol-3-...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C3(C)CC3)c(Cl)c2F)n1
Show InChI InChI=1S/C21H19ClFN9O2/c1-21(6-7-21)19-28-17(31-34-19)18(33)24-9-11-3-4-12(15(23)14(11)22)16-25-10-26-20(29-16)27-13-5-8-32(2)30-13/h3-5,8,10H,6-7,9H2,1-2H3,(H,24,33)(H,25,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480426
PNG
(4-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1nc(co1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-8-15(19-25-13-26-22(30-19)28-17-10-27-31(5)11-17)6-7-16(14)9-24-20(32)21-29-18(12-33-21)23(2,3)4/h6-8,10-13H,9H2,1-5H3,(H,24,32)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480008
PNG
(3-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2nc(no2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H24FN9O2/c1-12-13(10-24-18(33)19-29-20(31-34-19)22(2,3)4)6-7-14(16(12)23)17-25-11-26-21(28-17)27-15-8-9-32(5)30-15/h6-9,11H,10H2,1-5H3,(H,24,33)(H,25,26,27,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480079
PNG
(5-(tert-butyl)-N-(4-(4-((1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C22H22F3N9O2/c1-21(2,3)19-31-17(33-36-19)18(35)26-8-13-6-5-12(7-15(13)22(23,24)25)16-27-11-28-20(32-16)30-14-9-29-34(4)10-14/h5-7,9-11H,8H2,1-4H3,(H,26,35)(H,27,28,30,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480360
PNG
(3-(tert-butyl)-N-(2-chloro-3-fluoro-4-(4-((1-methy...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(Cl)c2F)cn1
Show InChI InChI=1S/C21H21ClFN9O2/c1-21(2,3)19-30-18(34-31-19)17(33)24-7-11-5-6-13(15(23)14(11)22)16-25-10-26-20(29-16)28-12-8-27-32(4)9-12/h5-6,8-10H,7H2,1-4H3,(H,24,33)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480385
PNG
(N-(5-fluoro-2-methyl-4-(4-((1-methyl-1H-pyrazol-4-...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1noc(n1)C1(C)CC1)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H22FN9O2/c1-12-6-15(17-25-11-26-21(30-17)28-14-9-27-32(3)10-14)16(23)7-13(12)8-24-19(33)18-29-20(34-31-18)22(2)4-5-22/h6-7,9-11H,4-5,8H2,1-3H3,(H,24,33)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480400
PNG
((R)-5-(tert-butyl)-N-(1-(3-chloro-2-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(Cl)c1C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26ClN9O2/c1-12-15(13(2)28-20(34)19-30-21(35-32-19)23(3,4)5)7-8-16(17(12)24)18-25-11-26-22(31-18)29-14-9-27-33(6)10-14/h7-11,13H,1-6H3,(H,28,34)(H,25,26,29,31)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480423
PNG
((R)-5-(tert-butyl)-N-(1-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2F)NC(=O)c2noc(n2)C(C)(C)C)n1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,3)23-31-21(34-37-23)22(36)29-17-8-6-5-7-15-14(17)9-10-16(19(15)26)20-27-13-28-24(32-20)30-18-11-12-35(4)33-18/h9-13,17H,5-8H2,1-4H3,(H,29,36)(H,27,28,30,32,33)/t17-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480081
PNG
(3-(tert-butyl)-N-(3-fluoro-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(c2F)C(F)(F)F)n1
Show InChI InChI=1S/C22H21F4N9O2/c1-21(2,3)19-32-18(37-34-19)17(36)27-9-11-5-6-12(15(23)14(11)22(24,25)26)16-28-10-29-20(31-16)30-13-7-8-35(4)33-13/h5-8,10H,9H2,1-4H3,(H,27,36)(H,28,29,30,31,33)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480371
PNG
(N-(2-methyl-4-(4-((1-methyl-1H-pyrazol-4-yl)amino)...)
Show SMILES Cc1cc(ccc1CNC(=O)c1noc(n1)C1(C)CC1)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H23N9O2/c1-13-8-14(17-24-12-25-21(29-17)27-16-10-26-31(3)11-16)4-5-15(13)9-23-19(32)18-28-20(33-30-18)22(2)6-7-22/h4-5,8,10-12H,6-7,9H2,1-3H3,(H,23,32)(H,24,25,27,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480372
PNG
(US10899753, Example 41)
Show SMILES C[C@H]1[C@@H](C)C1c1nc(no1)C(=O)NCc1ccc(cc1C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H25N9O2/c1-12-7-15(19-25-11-26-23(30-19)28-17-9-27-32(4)10-17)5-6-16(12)8-24-21(33)20-29-22(34-31-20)18-13(2)14(18)3/h5-7,9-11,13-14,18H,8H2,1-4H3,(H,24,33)(H,25,26,28,30)/t13-,14+,18?
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480382
PNG
(5-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1noc(n1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H24FN9O2/c1-12-6-15(17-25-11-26-21(30-17)28-14-9-27-32(5)10-14)16(23)7-13(12)8-24-19(33)18-29-20(34-31-18)22(2,3)4/h6-7,9-11H,8H2,1-5H3,(H,24,33)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480384
PNG
(2-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1nnn(n1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C21H24FN11O/c1-12-6-15(17-24-11-25-20(28-17)27-14-9-26-32(5)10-14)16(22)7-13(12)8-23-19(34)18-29-31-33(30-18)21(2,3)4/h6-7,9-11H,8H2,1-5H3,(H,23,34)(H,24,25,27,28)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480395
PNG
(Synthesis of (R)-3-(tert-butyl)-N-(1-(3-fluoro-2-m...)
Show SMILES C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(c(F)c1C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26FN9O2/c1-12-15(13(2)28-19(34)20-31-21(32-35-20)23(3,4)5)7-8-16(17(12)24)18-25-11-26-22(30-18)29-14-9-27-33(6)10-14/h7-11,13H,1-6H3,(H,28,34)(H,25,26,29,30)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480402
PNG
((R)-3-(tert-butyl)-N-(3-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2cc3CCCC[C@@H](NC(=O)c4nc(no4)C(C)(C)C)c3cc2F)n1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,3)23-32-22(37-34-23)21(36)29-18-8-6-5-7-14-11-16(17(26)12-15(14)18)20-27-13-28-24(31-20)30-19-9-10-35(4)33-19/h9-13,18H,5-8H2,1-4H3,(H,29,36)(H,27,28,30,31,33)/t18-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480408
PNG
(3-tert-butyl-N-[(5R)-8-[4-[(1-methylpyrazol-3-yl)a...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(CC(F)(F)F)Cc3c2)NC(=O)c2nc(no2)C(C)(C)C)cn1
Show InChI InChI=1S/C26H29F3N10O2/c1-25(2,3)23-36-22(41-37-23)21(40)34-19-7-8-39(13-26(27,28)29)11-16-9-15(5-6-18(16)19)20-30-14-31-24(35-20)33-17-10-32-38(4)12-17/h5-6,9-10,12,14,19H,7-8,11,13H2,1-4H3,(H,34,40)(H,30,31,33,35)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480410
PNG
(4-tert-butyl-N-[(5R)-8-[4-[(1-methylpyrazol-4-yl)a...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(CC(F)(F)F)Cc3c2)NC(=O)c2nc(co2)C(C)(C)C)cn1
Show InChI InChI=1S/C27H30F3N9O2/c1-26(2,3)21-13-41-24(36-21)23(40)35-20-7-8-39(14-27(28,29)30)11-17-9-16(5-6-19(17)20)22-31-15-32-25(37-22)34-18-10-33-38(4)12-18/h5-6,9-10,12-13,15,20H,7-8,11,14H2,1-4H3,(H,35,40)(H,31,32,34,37)/t20-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480412
PNG
((R)-3-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-3...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(Cc3c2)C2COC2)NC(=O)c2nc(no2)C(C)(C)C)n1
Show InChI InChI=1S/C27H32N10O3/c1-27(2,3)25-33-24(40-35-25)23(38)30-20-7-10-37(18-13-39-14-18)12-17-11-16(5-6-19(17)20)22-28-15-29-26(32-22)31-21-8-9-36(4)34-21/h5-6,8-9,11,15,18,20H,7,10,12-14H2,1-4H3,(H,30,38)(H,28,29,31,32,34)/t20-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480414
PNG
(2-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2coc(n2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H25FN8O2/c1-13-14(10-25-20(33)16-11-34-21(28-16)23(2,3)4)6-7-15(18(13)24)19-26-12-27-22(30-19)29-17-8-9-32(5)31-17/h6-9,11-12H,10H2,1-5H3,(H,25,33)(H,26,27,29,30,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480416
PNG
((R)-3-(tert-butyl)-N-(1-(2-chloro-3-fluoro-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(c(F)c1Cl)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H23ClFN9O2/c1-11(27-18(34)19-30-20(32-35-19)22(2,3)4)12-6-7-13(16(24)15(12)23)17-25-10-26-21(29-17)28-14-8-9-33(5)31-14/h6-11H,1-5H3,(H,27,34)(H,25,26,28,29,31)/t11-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480425
PNG
(N-(3-fluoro-2-methyl-4-(4-((1-methyl-1H-pyrazol-3-...)
Show SMILES Cc1c(CNC(=O)c2noc(n2)C2(C)CC2)ccc(c1F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H22FN9O2/c1-12-13(10-24-19(33)18-28-20(34-31-18)22(2)7-8-22)4-5-14(16(12)23)17-25-11-26-21(29-17)27-15-6-9-32(3)30-15/h4-6,9,11H,7-8,10H2,1-3H3,(H,24,33)(H,25,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480041
PNG
(3-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1nc(no1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H25N9O2/c1-13-8-14(17-24-12-25-21(28-17)27-16-10-26-31(5)11-16)6-7-15(13)9-23-18(32)19-29-20(30-33-19)22(2,3)4/h6-8,10-12H,9H2,1-5H3,(H,23,32)(H,24,25,27,28)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480092
PNG
(5-(tert-butyl)-N-(2-chloro-3-fluoro-4-(4-((1-methy...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(Cl)c2F)n1
Show InChI InChI=1S/C21H21ClFN9O2/c1-21(2,3)19-28-17(31-34-19)18(33)24-9-11-5-6-12(15(23)14(11)22)16-25-10-26-20(29-16)27-13-7-8-32(4)30-13/h5-8,10H,9H2,1-4H3,(H,24,33)(H,25,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480096
PNG
(US10899753, Example 27)
Show SMILES Cc1c(CNC(=O)c2nn(cc2F)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H25F2N9O/c1-13-14(8-26-21(35)19-17(24)11-34(32-19)23(2,3)4)6-7-16(18(13)25)20-27-12-28-22(31-20)30-15-9-29-33(5)10-15/h6-7,9-12H,8H2,1-5H3,(H,26,35)(H,27,28,30,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480362
PNG
(5-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2ncc(o2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H25FN8O2/c1-13-14(8-25-20(33)21-26-10-17(34-21)23(2,3)4)6-7-16(18(13)24)19-27-12-28-22(31-19)30-15-9-29-32(5)11-15/h6-7,9-12H,8H2,1-5H3,(H,25,33)(H,27,28,30,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480365
PNG
(3-tert-butyl-N-[(5R)-2-[4-[(1-methylpyrazol-4-yl)a...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2)NC(=O)c2nc(no2)C(C)(C)C)cn1
Show InChI InChI=1S/C25H29N9O2/c1-25(2,3)23-32-22(36-33-23)21(35)30-19-8-6-5-7-15-11-16(9-10-18(15)19)20-26-14-27-24(31-20)29-17-12-28-34(4)13-17/h9-14,19H,5-8H2,1-4H3,(H,30,35)(H,26,27,29,31)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480379
PNG
((R)-5-(1-fluoro-2-methylpropan-2-yl)-N-(2-(4-((1-m...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2)NC(=O)c2noc(n2)C(C)(C)CF)n1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,13-26)23-31-21(34-37-23)22(36)29-18-7-5-4-6-15-12-16(8-9-17(15)18)20-27-14-28-24(32-20)30-19-10-11-35(3)33-19/h8-12,14,18H,4-7,13H2,1-3H3,(H,29,36)(H,27,28,30,32,33)/t18-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480393
PNG
((R)-3-(tert-butyl)-N-(1-(3-fluoro-2-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(c(F)c1C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H26FN9O2/c1-12-14(13(2)27-19(34)20-30-21(32-35-20)23(3,4)5)7-8-15(17(12)24)18-25-11-26-22(29-18)28-16-9-10-33(6)31-16/h7-11,13H,1-6H3,(H,27,34)(H,25,26,28,29,31)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480420
PNG
(1-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2ccn(n2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26FN9O/c1-14-15(10-25-21(34)18-8-9-33(31-18)23(2,3)4)6-7-17(19(14)24)20-26-13-27-22(30-20)29-16-11-28-32(5)12-16/h6-9,11-13H,10H2,1-5H3,(H,25,34)(H,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480422
PNG
(3-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cc(no1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-8-15(20-25-13-26-22(29-20)28-17-11-27-31(5)12-17)6-7-16(14)10-24-21(32)18-9-19(30-33-18)23(2,3)4/h6-9,11-13H,10H2,1-5H3,(H,24,32)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480094
PNG
(3-(tert-butyl)-N-(2-chloro-3-fluoro-4-(4-((1-methy...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(Cl)c2F)n1
Show InChI InChI=1S/C21H21ClFN9O2/c1-21(2,3)19-29-18(34-31-19)17(33)24-9-11-5-6-12(15(23)14(11)22)16-25-10-26-20(28-16)27-13-7-8-32(4)30-13/h5-8,10H,9H2,1-4H3,(H,24,33)(H,25,26,27,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480364
PNG
(5-tert-butyl-N-[(5R)-2-[4-[(1-methylpyrazol-4-yl)a...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2)NC(=O)c2noc(n2)C(C)(C)C)cn1
Show InChI InChI=1S/C25H29N9O2/c1-25(2,3)23-31-21(33-36-23)22(35)30-19-8-6-5-7-15-11-16(9-10-18(15)19)20-26-14-27-24(32-20)29-17-12-28-34(4)13-17/h9-14,19H,5-8H2,1-4H3,(H,30,35)(H,26,27,29,32)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480368
PNG
(1-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cnn(c1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H27N9O/c1-15-8-16(20-25-14-26-22(30-20)29-19-11-27-31(5)13-19)6-7-17(15)9-24-21(33)18-10-28-32(12-18)23(2,3)4/h6-8,10-14H,9H2,1-5H3,(H,24,33)(H,25,26,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480377
PNG
(N-(3-fluoro-2-methyl-4-(4-((1-methyl-1H-pyrazol-4-...)
Show SMILES Cc1c(CNC(=O)c2noc(n2)C2(CF)CC2)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H21F2N9O2/c1-12-13(7-25-19(34)18-30-20(35-32-18)22(10-23)5-6-22)3-4-15(16(12)24)17-26-11-27-21(31-17)29-14-8-28-33(2)9-14/h3-4,8-9,11H,5-7,10H2,1-2H3,(H,25,34)(H,26,27,29,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480381
PNG
(US10899753, Example 55)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(C3CC3)c2F)n1
Show InChI InChI=1S/C24H26FN9O2/c1-24(2,3)22-31-21(36-33-22)20(35)26-11-14-7-8-15(18(25)17(14)13-5-6-13)19-27-12-28-23(30-19)29-16-9-10-34(4)32-16/h7-10,12-13H,5-6,11H2,1-4H3,(H,26,35)(H,27,28,29,30,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480394
PNG
((R)-5-(tert-butyl)-N-(1-(3-fluoro-2-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(F)c1C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26FN9O2/c1-12-15(13(2)28-20(34)19-30-21(35-32-19)23(3,4)5)7-8-16(17(12)24)18-25-11-26-22(31-18)29-14-9-27-33(6)10-14/h7-11,13H,1-6H3,(H,28,34)(H,25,26,29,31)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480398
PNG
((R)-5-(tert-butyl)-N-(1-(2-chloro-3-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(C)c1Cl)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26ClN9O2/c1-12-15(18-25-11-26-22(31-18)29-14-9-27-33(6)10-14)7-8-16(17(12)24)13(2)28-20(34)19-30-21(35-32-19)23(3,4)5/h7-11,13H,1-6H3,(H,28,34)(H,25,26,29,31)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480399
PNG
((R)-3-(tert-butyl)-N-(1-(3-chloro-2-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(c(Cl)c1C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26ClN9O2/c1-12-15(13(2)28-19(34)20-31-21(32-35-20)23(3,4)5)7-8-16(17(12)24)18-25-11-26-22(30-18)29-14-9-27-33(6)10-14/h7-11,13H,1-6H3,(H,28,34)(H,25,26,29,30)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480419
PNG
(1-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2cn(nn2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H25FN10O/c1-13-14(8-24-20(34)17-11-33(31-30-17)22(2,3)4)6-7-16(18(13)23)19-25-12-26-21(29-19)28-15-9-27-32(5)10-15/h6-7,9-12H,8H2,1-5H3,(H,24,34)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480005
PNG
(3-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1nc(no1)C(C)(C)C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H25N9O2/c1-13-10-14(17-24-12-25-21(27-17)26-16-8-9-31(5)29-16)6-7-15(13)11-23-18(32)19-28-20(30-33-19)22(2,3)4/h6-10,12H,11H2,1-5H3,(H,23,32)(H,24,25,26,27,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480006
PNG
(3-(tert-butyl)-N-(2-chloro-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(Cl)c2)n1
Show InChI InChI=1S/C21H22ClN9O2/c1-21(2,3)19-28-18(33-30-19)17(32)23-10-13-6-5-12(9-14(13)22)16-24-11-25-20(27-16)26-15-7-8-31(4)29-15/h5-9,11H,10H2,1-4H3,(H,23,32)(H,24,25,26,27,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480007
PNG
(5-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2noc(n2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H24FN9O2/c1-12-13(10-24-19(33)18-28-20(34-31-18)22(2,3)4)6-7-14(16(12)23)17-25-11-26-21(29-17)27-15-8-9-32(5)30-15/h6-9,11H,10H2,1-5H3,(H,24,33)(H,25,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480034
PNG
(5-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1noc(n1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H25N9O2/c1-13-8-14(17-24-12-25-21(29-17)27-16-10-26-31(5)11-16)6-7-15(13)9-23-19(32)18-28-20(33-30-18)22(2,3)4/h6-8,10-12H,9H2,1-5H3,(H,23,32)(H,24,25,27,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480078
PNG
(3-(tert-butyl)-N-(2-chloro-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(Cl)c2)cn1
Show InChI InChI=1S/C21H22ClN9O2/c1-21(2,3)19-29-18(33-30-19)17(32)23-8-13-6-5-12(7-15(13)22)16-24-11-25-20(28-16)27-14-9-26-31(4)10-14/h5-7,9-11H,8H2,1-4H3,(H,23,32)(H,24,25,27,28)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480363
PNG
(N-(3-fluoro-2-methyl-4-(4-((1-methyl-1H-pyrazol-4-...)
Show SMILES Cc1c(CNC(=O)c2noc(n2)C2(C)CC2)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H22FN9O2/c1-12-13(8-24-19(33)18-29-20(34-31-18)22(2)6-7-22)4-5-15(16(12)23)17-25-11-26-21(30-17)28-14-9-27-32(3)10-14/h4-5,9-11H,6-8H2,1-3H3,(H,24,33)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480373
PNG
(US10899753, Example 45)
Show SMILES Cc1c(CNC(=O)c2noc(n2)C(C)(C)CF)ccc(c1F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H23F2N9O2/c1-12-13(9-25-19(34)18-29-20(35-32-18)22(2,3)10-23)5-6-14(16(12)24)17-26-11-27-21(30-17)28-15-7-8-33(4)31-15/h5-8,11H,9-10H2,1-4H3,(H,25,34)(H,26,27,28,30,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480374
PNG
(US10899753, Example 47)
Show SMILES Cc1c(CNC(=O)c2nc(no2)C2(CF)CC2)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H21F2N9O2/c1-12-13(7-25-18(34)19-31-20(32-35-19)22(10-23)5-6-22)3-4-15(16(12)24)17-26-11-27-21(30-17)29-14-8-28-33(2)9-14/h3-4,8-9,11H,5-7,10H2,1-2H3,(H,25,34)(H,26,27,29,30)
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n/an/a<1n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480380
PNG
(US10899753, Example 54)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)CF)c(c2)C2CC2)n1
Show InChI InChI=1S/C24H26FN9O2/c1-24(2,12-25)22-30-20(33-36-22)21(35)26-11-16-7-6-15(10-17(16)14-4-5-14)19-27-13-28-23(31-19)29-18-8-9-34(3)32-18/h6-10,13-14H,4-5,11-12H2,1-3H3,(H,26,35)(H,27,28,29,31,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480403
PNG
((R)-5-(tert-butyl)-N-(3-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2cc3CCCC[C@@H](NC(=O)c4noc(n4)C(C)(C)C)c3cc2F)cn1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,3)23-32-21(34-37-23)22(36)31-19-8-6-5-7-14-9-17(18(26)10-16(14)19)20-27-13-28-24(33-20)30-15-11-29-35(4)12-15/h9-13,19H,5-8H2,1-4H3,(H,31,36)(H,27,28,30,33)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480411
PNG
((R)-2-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-3...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(CC(F)(F)F)Cc3c2)NC(=O)c2coc(n2)C(C)(C)C)n1
Show InChI InChI=1S/C27H30F3N9O2/c1-26(2,3)24-34-20(13-41-24)23(40)33-19-7-10-39(14-27(28,29)30)12-17-11-16(5-6-18(17)19)22-31-15-32-25(36-22)35-21-8-9-38(4)37-21/h5-6,8-9,11,13,15,19H,7,10,12,14H2,1-4H3,(H,33,40)(H,31,32,35,36,37)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480413
PNG
(2-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cnc(o1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-8-15(19-26-13-27-22(30-19)29-17-10-28-31(5)12-17)6-7-16(14)9-24-20(32)18-11-25-21(33-18)23(2,3)4/h6-8,10-13H,9H2,1-5H3,(H,24,32)(H,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480417
PNG
(2-(tert-butyl)-N-(2-chloro-3-fluoro-4-(4-((1-methy...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3coc(n3)C(C)(C)C)c(Cl)c2F)cn1
Show InChI InChI=1S/C22H22ClFN8O2/c1-22(2,3)20-30-15(10-34-20)19(33)25-7-12-5-6-14(17(24)16(12)23)18-26-11-27-21(31-18)29-13-8-28-32(4)9-13/h5-6,8-11H,7H2,1-4H3,(H,25,33)(H,26,27,29,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480421
PNG
(2-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1coc(n1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-8-15(19-25-13-26-22(30-19)28-17-10-27-31(5)11-17)6-7-16(14)9-24-20(32)18-12-33-21(29-18)23(2,3)4/h6-8,10-13H,9H2,1-5H3,(H,24,32)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480075
PNG
(5-(tert-butyl)-N-(2-chloro-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(Cl)c2)cn1
Show InChI InChI=1S/C21H22ClN9O2/c1-21(2,3)19-28-17(30-33-19)18(32)23-8-13-6-5-12(7-15(13)22)16-24-11-25-20(29-16)27-14-9-26-31(4)10-14/h5-7,9-11H,8H2,1-4H3,(H,23,32)(H,24,25,27,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480095
PNG
(5-tert-butyl-N-[(5R)-2-[4-[(1-methylpyrazol-3-yl)a...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2)NC(=O)c2noc(n2)C(C)(C)C)n1
Show InChI InChI=1S/C25H29N9O2/c1-25(2,3)23-30-21(33-36-23)22(35)28-18-8-6-5-7-15-13-16(9-10-17(15)18)20-26-14-27-24(31-20)29-19-11-12-34(4)32-19/h9-14,18H,5-8H2,1-4H3,(H,28,35)(H,26,27,29,31,32)/t18-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480369
PNG
(5-tert-butyl-N-((2-methyl-4-(4-((1-methylpyrazol-4...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cc(on1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-8-15(20-25-13-26-22(29-20)28-17-11-27-31(5)12-17)6-7-16(14)10-24-21(32)18-9-19(33-30-18)23(2,3)4/h6-9,11-13H,10H2,1-5H3,(H,24,32)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480383
PNG
(3-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1nc(no1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H24FN9O2/c1-12-6-15(17-25-11-26-21(29-17)28-14-9-27-32(5)10-14)16(23)7-13(12)8-24-18(33)19-30-20(31-34-19)22(2,3)4/h6-7,9-11H,8H2,1-5H3,(H,24,33)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480389
PNG
(5-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1cc(on1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H25FN8O2/c1-13-6-16(20-26-12-27-22(30-20)29-15-10-28-32(5)11-15)17(24)7-14(13)9-25-21(33)18-8-19(34-31-18)23(2,3)4/h6-8,10-12H,9H2,1-5H3,(H,25,33)(H,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480390
PNG
(2-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1coc(n1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H25FN8O2/c1-13-6-16(19-26-12-27-22(31-19)29-15-9-28-32(5)10-15)17(24)7-14(13)8-25-20(33)18-11-34-21(30-18)23(2,3)4/h6-7,9-12H,8H2,1-5H3,(H,25,33)(H,26,27,29,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480391
PNG
((R)-5-(tert-butyl)-N-(1-(2-chloro-3-fluoro-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(F)c1Cl)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H23ClFN9O2/c1-11(28-19(34)18-30-20(35-32-18)22(2,3)4)13-6-7-14(16(24)15(13)23)17-25-10-26-21(31-17)29-12-8-27-33(5)9-12/h6-11H,1-5H3,(H,28,34)(H,25,26,29,31)/t11-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480404
PNG
((R)-3-(tert-butyl)-N-(3-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2cc3CCCC[C@@H](NC(=O)c4nc(no4)C(C)(C)C)c3cc2F)cn1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,3)23-33-22(37-34-23)21(36)31-19-8-6-5-7-14-9-17(18(26)10-16(14)19)20-27-13-28-24(32-20)30-15-11-29-35(4)12-15/h9-13,19H,5-8H2,1-4H3,(H,31,36)(H,27,28,30,32)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480405
PNG
((R)-5-(tert-butyl)-N-(1-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2F)NC(=O)c2noc(n2)C(C)(C)C)cn1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,3)23-32-21(34-37-23)22(36)31-18-8-6-5-7-16-15(18)9-10-17(19(16)26)20-27-13-28-24(33-20)30-14-11-29-35(4)12-14/h9-13,18H,5-8H2,1-4H3,(H,31,36)(H,27,28,30,33)/t18-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480406
PNG
((R)-3-(tert-butyl)-N-(1-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2F)NC(=O)c2nc(no2)C(C)(C)C)n1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,3)23-32-22(37-34-23)21(36)29-17-8-6-5-7-15-14(17)9-10-16(19(15)26)20-27-13-28-24(31-20)30-18-11-12-35(4)33-18/h9-13,17H,5-8H2,1-4H3,(H,29,36)(H,27,28,30,31,33)/t17-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480409
PNG
(2-tert-butyl-N-[(5R)-8-[4-[(1-methylpyrazol-4-yl)a...)
Show SMILES Cn1cc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(CC(F)(F)F)Cc3c2)NC(=O)c2coc(n2)C(C)(C)C)cn1
Show InChI InChI=1S/C27H30F3N9O2/c1-26(2,3)24-36-21(13-41-24)23(40)35-20-7-8-39(14-27(28,29)30)11-17-9-16(5-6-19(17)20)22-31-15-32-25(37-22)34-18-10-33-38(4)12-18/h5-6,9-10,12-13,15,20H,7-8,11,14H2,1-4H3,(H,35,40)(H,31,32,34,37)/t20-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480424
PNG
((R)-2-(tert-butyl)-N-(1-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCCCc3c2F)NC(=O)c2coc(n2)C(C)(C)C)n1
Show InChI InChI=1S/C26H29FN8O2/c1-26(2,3)24-31-19(13-37-24)23(36)30-18-8-6-5-7-16-15(18)9-10-17(21(16)27)22-28-14-29-25(33-22)32-20-11-12-35(4)34-20/h9-14,18H,5-8H2,1-4H3,(H,30,36)(H,28,29,32,33,34)/t18-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480062
PNG
(5-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2noc(n2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H24FN9O2/c1-12-13(8-24-19(33)18-29-20(34-31-18)22(2,3)4)6-7-15(16(12)23)17-25-11-26-21(30-17)28-14-9-27-32(5)10-14/h6-7,9-11H,8H2,1-5H3,(H,24,33)(H,25,26,28,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480064
PNG
(3-(tert-butyl)-N-(3-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1c(CNC(=O)c2nc(no2)C(C)(C)C)ccc(c1F)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H24FN9O2/c1-12-13(8-24-18(33)19-30-20(31-34-19)22(2,3)4)6-7-15(16(12)23)17-25-11-26-21(29-17)28-14-9-27-32(5)10-14/h6-7,9-11H,8H2,1-5H3,(H,24,33)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480370
PNG
(2-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1nnn(n1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C21H25N11O/c1-13-8-14(17-23-12-24-20(27-17)26-16-10-25-31(5)11-16)6-7-15(13)9-22-19(33)18-28-30-32(29-18)21(2,3)4/h6-8,10-12H,9H2,1-5H3,(H,22,33)(H,23,24,26,27)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480378
PNG
(N-(5-fluoro-2-methyl-4-(4-((1-methyl-1H-pyrazol-4-...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1noc(n1)C1(CF)CC1)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H21F2N9O2/c1-12-5-15(17-26-11-27-21(31-17)29-14-8-28-33(2)9-14)16(24)6-13(12)7-25-19(34)18-30-20(35-32-18)22(10-23)3-4-22/h5-6,8-9,11H,3-4,7,10H2,1-2H3,(H,25,34)(H,26,27,29,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480388
PNG
(3-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1cc(no1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H25FN8O2/c1-13-6-16(20-26-12-27-22(30-20)29-15-10-28-32(5)11-15)17(24)7-14(13)9-25-21(33)18-8-19(31-34-18)23(2,3)4/h6-8,10-12H,9H2,1-5H3,(H,25,33)(H,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480387
PNG
(1-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1cnn(c1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26FN9O/c1-14-6-18(20-26-13-27-22(31-20)30-17-10-28-32(5)12-17)19(24)7-15(14)8-25-21(34)16-9-29-33(11-16)23(2,3)4/h6-7,9-13H,8H2,1-5H3,(H,25,34)(H,26,27,30,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480401
PNG
((R)-5-(tert-butyl)-N-(3-fluoro-2-(4-((1-methyl-1H-...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2cc3CCCC[C@@H](NC(=O)c4noc(n4)C(C)(C)C)c3cc2F)n1
Show InChI InChI=1S/C25H28FN9O2/c1-25(2,3)23-31-21(34-37-23)22(36)29-18-8-6-5-7-14-11-16(17(26)12-15(14)18)20-27-13-28-24(32-20)30-19-9-10-35(4)33-19/h9-13,18H,5-8H2,1-4H3,(H,29,36)(H,27,28,30,32,33)/t18-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480415
PNG
((R)-5-(tert-butyl)-N-(1-(2-chloro-3-fluoro-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(F)c1Cl)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H23ClFN9O2/c1-11(27-19(34)18-29-20(35-32-18)22(2,3)4)12-6-7-13(16(24)15(12)23)17-25-10-26-21(30-17)28-14-8-9-33(5)31-14/h6-11H,1-5H3,(H,27,34)(H,25,26,28,30,31)/t11-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480432
PNG
(3-(tert-butyl)-N-(4-(4-((1-methyl-1H-pyrazol-3-yl)...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(c2)C(F)(F)F)n1
Show InChI InChI=1S/C22H22F3N9O2/c1-21(2,3)19-31-18(36-33-19)17(35)26-10-13-6-5-12(9-14(13)22(23,24)25)16-27-11-28-20(30-16)29-15-7-8-34(4)32-15/h5-9,11H,10H2,1-4H3,(H,26,35)(H,27,28,29,30,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480448
PNG
((R)-4-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-3...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(CC(F)(F)F)Cc3c2)NC(=O)c2nc(co2)C(C)(C)C)n1
Show InChI InChI=1S/C27H30F3N9O2/c1-26(2,3)20-13-41-24(34-20)23(40)33-19-7-10-39(14-27(28,29)30)12-17-11-16(5-6-18(17)19)22-31-15-32-25(36-22)35-21-8-9-38(4)37-21/h5-6,8-9,11,13,15,19H,7,10,12,14H2,1-4H3,(H,33,40)(H,31,32,35,36,37)/t19-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480441
PNG
(5-(tert-butyl)-N-(2-(2,2-difluoroethyl)-4-(4-((1-m...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(CC(F)F)c2)n1
Show InChI InChI=1S/C23H25F2N9O2/c1-23(2,3)21-30-19(33-36-21)20(35)26-11-14-6-5-13(9-15(14)10-16(24)25)18-27-12-28-22(31-18)29-17-7-8-34(4)32-17/h5-9,12,16H,10-11H2,1-4H3,(H,26,35)(H,27,28,29,31,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480447
PNG
((R)-2-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-3...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(Cc3c2)C2COC2)NC(=O)c2coc(n2)C(C)(C)C)n1
Show InChI InChI=1S/C28H33N9O3/c1-28(2,3)26-32-22(15-40-26)25(38)31-21-7-10-37(19-13-39-14-19)12-18-11-17(5-6-20(18)21)24-29-16-30-27(34-24)33-23-8-9-36(4)35-23/h5-6,8-9,11,15-16,19,21H,7,10,12-14H2,1-4H3,(H,31,38)(H,29,30,33,34,35)/t21-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480437
PNG
(US10899753, Example 46)
Show SMILES Cc1c(CNC(=O)c2nc(no2)C2(CF)CC2)ccc(c1F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H21F2N9O2/c1-12-13(9-25-18(34)19-30-20(32-35-19)22(10-23)6-7-22)3-4-14(16(12)24)17-26-11-27-21(29-17)28-15-5-8-33(2)31-15/h3-5,8,11H,6-7,9-10H2,1-2H3,(H,25,34)(H,26,27,28,29,31)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480438
PNG
(US10899753, Example 52)
Show SMILES Cc1c(CNC(=O)c2noc(n2)C2(CC2)C(F)(F)F)ccc(c1F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H19F4N9O2/c1-11-12(9-27-18(36)17-31-19(37-34-17)21(6-7-21)22(24,25)26)3-4-13(15(11)23)16-28-10-29-20(32-16)30-14-5-8-35(2)33-14/h3-5,8,10H,6-7,9H2,1-2H3,(H,27,36)(H,28,29,30,32,33)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480433
PNG
(5-(tert-butyl)-N-(3-fluoro-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(c2F)C(F)(F)F)n1
Show InChI InChI=1S/C22H21F4N9O2/c1-21(2,3)19-31-17(34-37-19)18(36)27-9-11-5-6-12(15(23)14(11)22(24,25)26)16-28-10-29-20(32-16)30-13-7-8-35(4)33-13/h5-8,10H,9H2,1-4H3,(H,27,36)(H,28,29,30,32,33)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480440
PNG
(3-(tert-butyl)-N-(2-(difluoromethyl)-3-fluoro-4-(4...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(C(F)F)c2F)n1
Show InChI InChI=1S/C22H22F3N9O2/c1-22(2,3)20-31-19(36-33-20)18(35)26-9-11-5-6-12(15(23)14(11)16(24)25)17-27-10-28-21(30-17)29-13-7-8-34(4)32-13/h5-8,10,16H,9H2,1-4H3,(H,26,35)(H,27,28,29,30,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480450
PNG
(1-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cn(nn1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H26N10O/c1-14-8-15(19-24-13-25-21(28-19)27-17-10-26-31(5)11-17)6-7-16(14)9-23-20(33)18-12-32(30-29-18)22(2,3)4/h6-8,10-13H,9H2,1-5H3,(H,23,33)(H,24,25,27,28)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480431
PNG
(5-(tert-butyl)-N-(4-(4-((1-methyl-1H-pyrazol-3-yl)...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(c2)C(F)(F)F)n1
Show InChI InChI=1S/C22H22F3N9O2/c1-21(2,3)19-30-17(33-36-19)18(35)26-10-13-6-5-12(9-14(13)22(23,24)25)16-27-11-28-20(31-16)29-15-7-8-34(4)32-15/h5-9,11H,10H2,1-4H3,(H,26,35)(H,27,28,29,31,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480436
PNG
(US10899753, Example 44)
Show SMILES Cc1cc(ccc1CNC(=O)c1noc(n1)C(C)(C)CF)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H24FN9O2/c1-13-9-14(17-25-12-26-21(29-17)27-16-7-8-32(4)30-16)5-6-15(13)10-24-19(33)18-28-20(34-31-18)22(2,3)11-23/h5-9,12H,10-11H2,1-4H3,(H,24,33)(H,25,26,27,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480444
PNG
((R)-5-(tert-butyl)-N-(1-(2-chloro-3-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(C)c1Cl)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H26ClN9O2/c1-12-14(18-25-11-26-22(30-18)28-16-9-10-33(6)31-16)7-8-15(17(12)24)13(2)27-20(34)19-29-21(35-32-19)23(3,4)5/h7-11,13H,1-6H3,(H,27,34)(H,25,26,28,30,31)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480427
PNG
(5-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1noc(n1)C(C)(C)C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C22H25N9O2/c1-13-10-14(17-24-12-25-21(28-17)26-16-8-9-31(5)29-16)6-7-15(13)11-23-19(32)18-27-20(33-30-18)22(2,3)4/h6-10,12H,11H2,1-5H3,(H,23,32)(H,24,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480428
PNG
(2-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cnc(o1)C(C)(C)C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-10-15(19-26-13-27-22(29-19)28-18-8-9-31(5)30-18)6-7-16(14)11-24-20(32)17-12-25-21(33-17)23(2,3)4/h6-10,12-13H,11H2,1-5H3,(H,24,32)(H,26,27,28,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480435
PNG
(3-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cc(no1)C(C)(C)C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-10-15(20-25-13-26-22(28-20)27-19-8-9-31(5)29-19)6-7-16(14)12-24-21(32)17-11-18(30-33-17)23(2,3)4/h6-11,13H,12H2,1-5H3,(H,24,32)(H,25,26,27,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480443
PNG
((R)-3-(tert-butyl)-N-(1-(2-chloro-3-methyl-4-(4-((...)
Show SMILES C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(c(C)c1Cl)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C23H26ClN9O2/c1-12-15(18-25-11-26-22(30-18)29-14-9-27-33(6)10-14)7-8-16(17(12)24)13(2)28-19(34)20-31-21(32-35-20)23(3,4)5/h7-11,13H,1-6H3,(H,28,34)(H,25,26,29,30)/t13-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480446
PNG
((R)-3-(tert-butyl)-N-(1-(2-(difluoromethyl)-3-fluo...)
Show SMILES C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(c(F)c1C(F)F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H24F3N9O2/c1-11(29-19(36)20-32-21(34-37-20)23(2,3)4)12-6-7-13(16(24)15(12)17(25)26)18-27-10-28-22(31-18)30-14-8-9-35(5)33-14/h6-11,17H,1-5H3,(H,29,36)(H,27,28,30,31,33)/t11-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480430
PNG
(5-(tert-butyl)-N-(2-chloro-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3noc(n3)C(C)(C)C)c(Cl)c2)n1
Show InChI InChI=1S/C21H22ClN9O2/c1-21(2,3)19-27-17(30-33-19)18(32)23-10-13-6-5-12(9-14(13)22)16-24-11-25-20(28-16)26-15-7-8-31(4)29-15/h5-9,11H,10H2,1-4H3,(H,23,32)(H,24,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480442
PNG
(3-(tert-butyl)-N-(2-(2,2-difluoroethyl)-4-(4-((1-m...)
Show SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(CC(F)F)c2)n1
Show InChI InChI=1S/C23H25F2N9O2/c1-23(2,3)21-31-20(36-33-21)19(35)26-11-14-6-5-13(9-15(14)10-16(24)25)18-27-12-28-22(30-18)29-17-7-8-34(4)32-17/h5-9,12,16H,10-11H2,1-4H3,(H,26,35)(H,27,28,29,30,32)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480449
PNG
((R)-2-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-3...)
Show SMILES CN1CC[C@@H](NC(=O)c2nc(no2)C(C)(C)C)c2ccc(cc2C1)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C25H30N10O2/c1-25(2,3)23-31-22(37-33-23)21(36)28-18-8-10-34(4)13-16-12-15(6-7-17(16)18)20-26-14-27-24(30-20)29-19-9-11-35(5)32-19/h6-7,9,11-12,14,18H,8,10,13H2,1-5H3,(H,28,36)(H,26,27,29,30,32)/t18-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480451
PNG
(5-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1nnc(o1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H25N9O2/c1-13-8-14(17-24-12-25-21(28-17)27-16-10-26-31(5)11-16)6-7-15(13)9-23-18(32)19-29-30-20(33-19)22(2,3)4/h6-8,10-12H,9H2,1-5H3,(H,23,32)(H,24,25,27,28)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480429
PNG
(1-(tert-butyl)-4-fluoro-N-(2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(ccc1CNC(=O)c1nn(cc1F)C(C)(C)C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H26FN9O/c1-14-10-15(20-26-13-27-22(29-20)28-18-8-9-32(5)30-18)6-7-16(14)11-25-21(34)19-17(24)12-33(31-19)23(2,3)4/h6-10,12-13H,11H2,1-5H3,(H,25,34)(H,26,27,28,29,30)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480445
PNG
((R)-5-(tert-butyl)-N-(1-(2-(difluoromethyl)-3-fluo...)
Show SMILES C[C@@H](NC(=O)c1noc(n1)C(C)(C)C)c1ccc(c(F)c1C(F)F)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H24F3N9O2/c1-11(29-20(36)19-31-21(37-34-19)23(2,3)4)12-6-7-13(16(24)15(12)17(25)26)18-27-10-28-22(32-18)30-14-8-9-35(5)33-14/h6-11,17H,1-5H3,(H,29,36)(H,27,28,30,32,33)/t11-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480434
PNG
(5-(tert-butyl)-N-(2-methyl-4-(4-((1-methyl-1H-pyra...)
Show SMILES Cc1cc(ccc1CNC(=O)c1cc(on1)C(C)(C)C)-c1ncnc(Nc2ccn(C)n2)n1
Show InChI InChI=1S/C23H26N8O2/c1-14-10-15(20-25-13-26-22(28-20)27-19-8-9-31(5)29-19)6-7-16(14)12-24-21(32)17-11-18(33-30-17)23(2,3)4/h6-11,13H,12H2,1-5H3,(H,24,32)(H,25,26,27,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480439
PNG
(1-(tert-butyl)-N-(5-fluoro-2-methyl-4-(4-((1-methy...)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1cn(nn1)C(C)(C)C)-c1ncnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C22H25FN10O/c1-13-6-16(19-25-12-26-21(29-19)28-15-9-27-32(5)10-15)17(23)7-14(13)8-24-20(34)18-11-33(31-30-18)22(2,3)4/h6-7,9-12H,8H2,1-5H3,(H,24,34)(H,25,26,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...


US Patent US10899753 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%