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Patent code US10906890

Compile Data Set for Download or QSAR
Found 112 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens (Human))
BDBM481000
PNG
(US10906890, Example 11.0 | US10906890, Example 9.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C21H21FN8O4S/c1-13(9-16-23-10-15(22)11-24-16)35(31,32)29-21-28-27-18(14-7-5-4-6-8-14)30(21)17-19(33-2)25-12-26-20(17)34-3/h4-8,10-13H,9H2,1-3H3,(H,28,29)/t13-/m0/s1
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n/an/an/an/a 40n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481004
PNG
(US10906890, Example 13.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C27H32N6O5S/c1-17(2)38-24(25-28-15-18(3)16-29-25)19(4)39(34,35)32-27-31-30-26(20-11-8-7-9-12-20)33(27)23-21(36-5)13-10-14-22(23)37-6/h7-17,19,24H,1-6H3,(H,31,32)/t19-,24+/m0/s1
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n/an/an/an/a 0.220n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481021
PNG
(US10906890, Example 30.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H]2CCCN(C2)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C24H27N9O4S/c1-16-12-25-23(26-13-16)32-11-7-10-18(14-32)38(34,35)31-24-30-29-20(17-8-5-4-6-9-17)33(24)19-21(36-2)27-15-28-22(19)37-3/h4-6,8-9,12-13,15,18H,7,10-11,14H2,1-3H3,(H,30,31)/t18-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481022
PNG
(US10906890, Example 31.0 | US10906890, Example 32....)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H24ClN9O4S/c1-36-20-18(21(37-2)28-14-27-20)33-19(15-7-4-3-5-8-15)29-30-23(33)31-38(34,35)17-9-6-10-32(13-17)22-25-11-16(24)12-26-22/h3-5,7-8,11-12,14,17H,6,9-10,13H2,1-2H3,(H,30,31)/t17-/m0/s1
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n/an/an/an/a 340n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481022
PNG
(US10906890, Example 31.0 | US10906890, Example 32....)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H24ClN9O4S/c1-36-20-18(21(37-2)28-14-27-20)33-19(15-7-4-3-5-8-15)29-30-23(33)31-38(34,35)17-9-6-10-32(13-17)22-25-11-16(24)12-26-22/h3-5,7-8,11-12,14,17H,6,9-10,13H2,1-2H3,(H,30,31)/t17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481039
PNG
(US10906890, Example 50.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cccc(c1)C#N
Show InChI InChI=1S/C24H25N9O4S/c1-14-11-26-20(27-12-14)15(2)16(3)38(34,35)32-24-31-30-21(18-8-6-7-17(9-18)10-25)33(24)19-22(36-4)28-13-29-23(19)37-5/h6-9,11-13,15-16H,1-5H3,(H,31,32)/t15-,16-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481052
PNG
(US10906890, Example 64.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@H](CN(C2)c2ncc(F)cn2)OC(C)C)nnc1-c1ccccc1
Show InChI InChI=1S/C26H30FN9O5S/c1-16(2)41-19-10-20(14-35(13-19)25-28-11-18(27)12-29-25)42(37,38)34-26-33-32-22(17-8-6-5-7-9-17)36(26)21-23(39-3)30-15-31-24(21)40-4/h5-9,11-12,15-16,19-20H,10,13-14H2,1-4H3,(H,33,34)/t19-,20+/m1/s1
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n/an/an/an/a 4.70n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481058
PNG
(US10906890, Example 70.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(Cl)c(Cl)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H26Cl2N6O5S/c1-14-12-28-23(29-13-14)22(38-5)15(2)39(34,35)32-25-31-30-24(16-9-10-17(26)18(27)11-16)33(25)21-19(36-3)7-6-8-20(21)37-4/h6-13,15,22H,1-5H3,(H,31,32)/t15-,22-/m0/s1
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n/an/an/an/a 3.80n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481063
PNG
(US10906890, Example 75.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(OC)c(c2)C#N)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H29N7O6S/c1-16-14-29-25(30-15-16)24(40-6)17(2)41(35,36)33-27-32-31-26(18-10-11-20(37-3)19(12-18)13-28)34(27)23-21(38-4)8-7-9-22(23)39-5/h7-12,14-15,17,24H,1-6H3,(H,32,33)/t17-,24-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481065
PNG
(US10906890, Example 77.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H28N6O5S/c1-16-14-26-23(27-15-16)22(36-5)17(2)37(32,33)30-25-29-28-24(18-10-7-6-8-11-18)31(25)21-19(34-3)12-9-13-20(21)35-4/h6-15,17,22H,1-5H3,(H,29,30)/t17-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481072
PNG
(US10906890, Example 84.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc3nccnc3c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H28N8O5S/c1-16-14-30-25(31-15-16)24(40-5)17(2)41(36,37)34-27-33-32-26(18-9-10-19-20(13-18)29-12-11-28-19)35(27)23-21(38-3)7-6-8-22(23)39-4/h6-15,17,24H,1-5H3,(H,33,34)/t17-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481079
PNG
(US10906890, Example 91.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3cn(C)nc23)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C26H27ClN8O5S/c1-15(23(40-5)24-28-12-17(27)13-29-24)41(36,37)33-26-31-30-25(18-9-6-8-16-14-34(2)32-21(16)18)35(26)22-19(38-3)10-7-11-20(22)39-4/h6-15,23H,1-5H3,(H,31,33)/t15-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481082
PNG
(US10906890, Example 94.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3cn(C)nc23)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H25ClN10O5S/c1-13(19(38-3)20-26-9-15(25)10-27-20)41(36,37)33-24-31-30-21(16-8-6-7-14-11-34(2)32-17(14)16)35(24)18-22(39-4)28-12-29-23(18)40-5/h6-13,19H,1-5H3,(H,31,33)/t13-,19-/m0/s1
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n/an/an/an/a 2.90n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481085
PNG
(US10906890, Example 97.0)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C21H25ClN6O4S/c1-14(17(32-3)18-23-11-16(22)12-24-18)33(29,30)27-20-26-25-19(15-7-5-4-6-8-15)28(20)21(9-10-21)13-31-2/h4-8,11-12,14,17H,9-10,13H2,1-3H3,(H,26,27)/t14-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480993
PNG
(US10906890, Example 2.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(c2)C#N)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H25N9O5S/c1-14-11-26-20(27-12-14)19(36-3)15(2)39(34,35)32-24-31-30-21(17-8-6-7-16(9-17)10-25)33(24)18-22(37-4)28-13-29-23(18)38-5/h6-9,11-13,15,19H,1-5H3,(H,31,32)/t15-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480995
PNG
(US10906890, Example 4.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H26N8O5S/c1-14-11-24-19(25-12-14)18(34-3)15(2)37(32,33)30-23-29-28-20(16-9-7-6-8-10-16)31(23)17-21(35-4)26-13-27-22(17)36-5/h6-13,15,18H,1-5H3,(H,29,30)/t15-,18-/m0/s1
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n/an/an/an/a 2.90n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481008
PNG
(US10906890, Example 17.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C22H23ClN8O4S/c1-13(18-24-10-16(23)11-25-18)14(2)36(32,33)30-22-29-28-19(15-8-6-5-7-9-15)31(22)17-20(34-3)26-12-27-21(17)35-4/h5-14H,1-4H3,(H,29,30)/t13-,14-/m0/s1
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n/an/an/an/a 0.890n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481013
PNG
(US10906890, Example 22.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H]2CCCN(C2)c2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H26FN7O4S/c1-36-20-11-6-12-21(37-2)22(20)33-23(17-8-4-3-5-9-17)29-30-25(33)31-38(34,35)19-10-7-13-32(16-19)24-27-14-18(26)15-28-24/h3-6,8-9,11-12,14-15,19H,7,10,13,16H2,1-2H3,(H,30,31)/t19-/m1/s1
PDB

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n/an/an/an/a 170n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481020
PNG
(US10906890, Example 29.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C24H27N9O4S/c1-16-12-25-23(26-13-16)32-11-7-10-18(14-32)38(34,35)31-24-30-29-20(17-8-5-4-6-9-17)33(24)19-21(36-2)27-15-28-22(19)37-3/h4-6,8-9,12-13,15,18H,7,10-11,14H2,1-3H3,(H,30,31)/t18-/m0/s1
PDB

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n/an/an/an/a 390n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481033
PNG
(US10906890, Example 44.0)
Show SMILES C[C@@H]([C@H](O[Si](C)(C)C(C)(C)C)c1ncc(C)cn1)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F
Show InChI InChI=1S/C28H34F2N6O3SSi/c1-18-16-31-25(32-17-18)24(39-41(6,7)28(3,4)5)19(2)40(37,38)35-27-34-33-26(20-12-9-8-10-13-20)36(27)23-21(29)14-11-15-22(23)30/h8-17,19,24H,1-7H3,(H,34,35)/t19-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481041
PNG
(US10906890, Example 53.0 | US10906890, Example 56....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@@H](O)CN(C2)c2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H26FN7O5S/c1-37-20-9-6-10-21(38-2)22(20)33-23(16-7-4-3-5-8-16)29-30-25(33)31-39(35,36)19-11-18(34)14-32(15-19)24-27-12-17(26)13-28-24/h3-10,12-13,18-19,34H,11,14-15H2,1-2H3,(H,30,31)/t18-,19+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481054
PNG
(US10906890, Example 66.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc3OCOc3c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H28N6O7S/c1-15-12-27-24(28-13-15)23(37-5)16(2)40(33,34)31-26-30-29-25(17-9-10-18-21(11-17)39-14-38-18)32(26)22-19(35-3)7-6-8-20(22)36-4/h6-13,16,23H,14H2,1-5H3,(H,30,31)/t16-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481060
PNG
(US10906890, Example 72.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(F)c(F)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H26F2N6O5S/c1-14-12-28-23(29-13-14)22(38-5)15(2)39(34,35)32-25-31-30-24(16-9-10-17(26)18(27)11-16)33(25)21-19(36-3)7-6-8-20(21)37-4/h6-13,15,22H,1-5H3,(H,31,32)/t15-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481084
PNG
(US10906890, Example 96.0)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C21H27ClN6O5S/c1-14(18(33-4)19-23-10-16(22)11-24-19)34(29,30)27-21-26-25-20(15-8-6-5-7-9-15)28(21)17(12-31-2)13-32-3/h5-11,14,17-18H,12-13H2,1-4H3,(H,26,27)/t14-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481086
PNG
(US10906890, Example 98.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1C1(C)CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H23ClN6O3S/c1-13(16(30-3)17-22-11-15(21)12-23-17)31(28,29)26-19-25-24-18(14-7-5-4-6-8-14)27(19)20(2)9-10-20/h4-8,11-13,16H,9-10H2,1-3H3,(H,25,26)/t13-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481095
PNG
(US10906890, Example 120.0)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3nn(C)cc23)n1C1CCOCC1)c1ncc(C)cn1
Show InChI InChI=1S/C24H30N8O3S/c1-15-12-25-22(26-13-15)16(2)17(3)36(33,34)30-24-28-27-23(32(24)18-8-10-35-11-9-18)19-6-5-7-21-20(19)14-31(4)29-21/h5-7,12-14,16-18H,8-11H2,1-4H3,(H,28,30)/t16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481096
PNG
(US10906890, Example 121.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(c2)S(C)(=O)=O)n1C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H23ClN6O5S2/c1-12(17(32-2)18-22-10-14(21)11-23-18)34(30,31)26-20-25-24-19(27(20)15-7-8-15)13-5-4-6-16(9-13)33(3,28)29/h4-6,9-12,15,17H,7-8H2,1-3H3,(H,25,26)/t12-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480992
PNG
(US10906890, Example 1.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(Br)c2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H25BrN8O5S/c1-13-10-25-19(26-11-13)18(35-3)14(2)38(33,34)31-23-30-29-20(15-7-6-8-16(24)9-15)32(23)17-21(36-4)27-12-28-22(17)37-5/h6-12,14,18H,1-5H3,(H,30,31)/t14-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480994
PNG
(US10906890, Example 3.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(Cl)c2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H25ClN8O5S/c1-13-10-25-19(26-11-13)18(35-3)14(2)38(33,34)31-23-30-29-20(15-7-6-8-16(24)9-15)32(23)17-21(36-4)27-12-28-22(17)37-5/h6-12,14,18H,1-5H3,(H,30,31)/t14-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481018
PNG
(US10906890, Example 27.0 | US10906890, Example 28....)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H24FN9O4S/c1-36-20-18(21(37-2)28-14-27-20)33-19(15-7-4-3-5-8-15)29-30-23(33)31-38(34,35)17-9-6-10-32(13-17)22-25-11-16(24)12-26-22/h3-5,7-8,11-12,14,17H,6,9-10,13H2,1-2H3,(H,30,31)/t17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481025
PNG
(US10906890, Example 34.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H]2CCCN(C2)C(=O)OC(C)(C)C)nnc1-c1ccccc1
Show InChI InChI=1S/C26H33N5O6S/c1-26(2,3)37-25(32)30-16-10-13-19(17-30)38(33,34)29-24-28-27-23(18-11-7-6-8-12-18)31(24)22-20(35-4)14-9-15-21(22)36-5/h6-9,11-12,14-15,19H,10,13,16-17H2,1-5H3,(H,28,29)/t19-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481028
PNG
(US10906890, Example 39.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc3OC(F)(F)Oc3c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H26F2N6O7S/c1-14-12-29-23(30-13-14)22(39-5)15(2)42(35,36)33-25-32-31-24(16-9-10-17-20(11-16)41-26(27,28)40-17)34(25)21-18(37-3)7-6-8-19(21)38-4/h6-13,15,22H,1-5H3,(H,32,33)/t15-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481037
PNG
(US10906890, Example 48.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N8O4S/c1-13-10-28-19(29-11-13)14(2)15(3)40(36,37)34-23-33-32-20(16-7-6-8-17(9-16)24(25,26)27)35(23)18-21(38-4)30-12-31-22(18)39-5/h6-12,14-15H,1-5H3,(H,33,34)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481042
PNG
(US10906890, Example 54.0 | US10906890, Example 55....)
Show SMILES COc1ccnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C24H27N7O4S/c1-15-13-27-19(14-26-15)16(2)17(3)36(32,33)30-24-29-28-22(18-9-7-6-8-10-18)31(24)21-20(34-4)11-12-25-23(21)35-5/h6-14,16-17H,1-5H3,(H,29,30)/t16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481049
PNG
(US10906890, Example 61.0)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1C1CCOCC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN6O3S/c1-14(19-23-12-17(22)13-24-19)15(2)32(29,30)27-21-26-25-20(16-6-4-3-5-7-16)28(21)18-8-10-31-11-9-18/h3-7,12-15,18H,8-11H2,1-2H3,(H,26,27)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481051
PNG
(US10906890, Example 63.0)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1C1CCOCC1)c1ncc(C)cn1
Show InChI InChI=1S/C24H32N6O4S/c1-16(2)34-21(22-25-14-17(3)15-26-22)18(4)35(31,32)29-24-28-27-23(19-8-6-5-7-9-19)30(24)20-10-12-33-13-11-20/h5-9,14-16,18,20-21H,10-13H2,1-4H3,(H,28,29)/t18-,21+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481055
PNG
(US10906890, Example 67.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2F)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H27FN6O5S/c1-15-13-27-23(28-14-15)22(37-5)16(2)38(33,34)31-25-30-29-24(17-9-6-7-10-18(17)26)32(25)21-19(35-3)11-8-12-20(21)36-4/h6-14,16,22H,1-5H3,(H,30,31)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481062
PNG
(US10906890, Example 74.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc3nc(N)sc3c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H28N8O5S2/c1-14-12-28-23(29-13-14)22(39-5)15(2)41(35,36)33-26-32-31-24(16-9-10-17-20(11-16)40-25(27)30-17)34(26)21-18(37-3)7-6-8-19(21)38-4/h6-13,15,22H,1-5H3,(H2,27,30)(H,32,33)/t15-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481078
PNG
(US10906890, Example 90.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3ncccc23)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H29N7O5S/c1-17-15-30-26(31-16-17)25(40-5)18(2)41(36,37)34-28-33-32-27(20-9-6-11-21-19(20)10-8-14-29-21)35(28)24-22(38-3)12-7-13-23(24)39-4/h6-16,18,25H,1-5H3,(H,33,34)/t18-,25-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481090
PNG
(US10906890, Example 115.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3nn(C)cc23)n1C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H23ClN8O3S/c1-12(18(33-3)19-23-9-13(22)10-24-19)34(31,32)28-21-26-25-20(30(21)14-7-8-14)15-5-4-6-17-16(15)11-29(2)27-17/h4-6,9-12,14,18H,7-8H2,1-3H3,(H,26,28)/t12-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481093
PNG
(US10906890, Example 118.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2OC)n1[C@@H]1CCCOC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H27ClN6O5S/c1-14(19(33-3)20-24-11-15(23)12-25-20)35(30,31)28-22-27-26-21(17-8-4-5-9-18(17)32-2)29(22)16-7-6-10-34-13-16/h4-5,8-9,11-12,14,16,19H,6-7,10,13H2,1-3H3,(H,27,28)/t14-,16+,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481102
PNG
(US10906890, Example 128.0)
Show SMILES COc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2Br)n1C1COC(C)(C)OC1
Show InChI InChI=1S/C23H29BrN6O5S/c1-14(20-25-10-17(33-5)11-26-20)15(2)36(31,32)29-22-28-27-21(18-8-6-7-9-19(18)24)30(22)16-12-34-23(3,4)35-13-16/h6-11,14-16H,12-13H2,1-5H3,(H,28,29)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480998
PNG
(US10906890, Example 7.0 | US10906890, Example 8.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H23FN6O4S/c1-15(12-20-25-13-17(24)14-26-20)35(31,32)29-23-28-27-22(16-8-5-4-6-9-16)30(23)21-18(33-2)10-7-11-19(21)34-3/h4-11,13-15H,12H2,1-3H3,(H,28,29)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481007
PNG
(US10906890, Example 16.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C24H25ClN6O4S/c1-15(22-26-13-18(25)14-27-22)16(2)36(32,33)30-24-29-28-23(17-9-6-5-7-10-17)31(24)21-19(34-3)11-8-12-20(21)35-4/h5-16H,1-4H3,(H,29,30)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481009
PNG
(US10906890, Example 18.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C24H26N6O5S/c1-15-13-25-22(26-14-15)21(31)16(2)36(32,33)29-24-28-27-23(17-9-6-5-7-10-17)30(24)20-18(34-3)11-8-12-19(20)35-4/h5-14,16,21,31H,1-4H3,(H,28,29)/t16-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481010
PNG
(US10906890, Example 19.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1-c1ccccc1
Show InChI InChI=1S/C22H21ClN6O4S/c1-32-20-18(21(33-2)25-14-24-20)29-19(16-6-4-3-5-7-16)26-27-22(29)28-34(30,31)13-12-15-8-10-17(23)11-9-15/h3-11,14H,12-13H2,1-2H3,(H,27,28)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481034
PNG
(US10906890, Example 45.0)
Show SMILES C[C@@H]([C@H](O)c1ncc(C)cn1)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F
Show InChI InChI=1S/C22H20F2N6O3S/c1-13-11-25-20(26-12-13)19(31)14(2)34(32,33)29-22-28-27-21(15-7-4-3-5-8-15)30(22)18-16(23)9-6-10-17(18)24/h3-12,14,19,31H,1-2H3,(H,28,29)/t14-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481040
PNG
(US10906890, Example 52.0)
Show SMILES COc1ccnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C24H27N7O4S/c1-15-13-27-19(14-26-15)16(2)17(3)36(32,33)30-24-29-28-22(18-9-7-6-8-10-18)31(24)21-20(34-4)11-12-25-23(21)35-5/h6-14,16-17H,1-5H3,(H,29,30)/t16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481056
PNG
(US10906890, Example 68.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)NC1=NN=C([NH+]1c1c(OC)cccc1OC)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ncc(C)cn1
Show InChI InChI=1S/C27H26F6N6O5S/c1-14-12-34-23(35-13-14)22(44-5)15(2)45(40,41)38-25-37-36-24(39(25)21-19(42-3)7-6-8-20(21)43-4)16-9-17(26(28,29)30)11-18(10-16)27(31,32)33/h6-13,15,22H,1-5H3,(H,37,38)/p+1/t15-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481057
PNG
(US10906890, Example 69.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(OC(F)(F)F)cc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H27F3N6O6S/c1-15-13-30-23(31-14-15)22(40-5)16(2)42(36,37)34-25-33-32-24(17-9-11-18(12-10-17)41-26(27,28)29)35(25)21-19(38-3)7-6-8-20(21)39-4/h6-14,16,22H,1-5H3,(H,33,34)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481064
PNG
(US10906890, Example 76.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H30N6O6S/c1-16-14-27-24(28-15-16)23(38-6)17(2)39(33,34)31-26-30-29-25(18-9-7-10-19(13-18)35-3)32(26)22-20(36-4)11-8-12-21(22)37-5/h7-15,17,23H,1-6H3,(H,30,31)/t17-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481071
PNG
(US10906890, Example 83.0)
Show SMILES CCN(CC)c1ccc(cc1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C29H37N7O5S/c1-8-35(9-2)22-15-13-21(14-16-22)28-32-33-29(36(28)25-23(39-5)11-10-12-24(25)40-6)34-42(37,38)20(4)26(41-7)27-30-17-19(3)18-31-27/h10-18,20,26H,8-9H2,1-7H3,(H,33,34)/t20-,26-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481089
PNG
(US10906890, Example 114.0)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc2nn(C)cc12
Show InChI InChI=1S/C23H27ClN8O4S/c1-14(19(36-4)20-25-10-15(24)11-26-20)37(33,34)30-22-28-27-21(32(22)23(8-9-23)13-35-3)16-6-5-7-18-17(16)12-31(2)29-18/h5-7,10-12,14,19H,8-9,13H2,1-4H3,(H,28,30)/t14-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481092
PNG
(US10906890, Example 117.0)
Show SMILES COCC1(CCC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc2nn(C)cc12
Show InChI InChI=1S/C24H29ClN8O4S/c1-15(20(37-4)21-26-11-16(25)12-27-21)38(34,35)31-23-29-28-22(33(23)24(14-36-3)9-6-10-24)17-7-5-8-19-18(17)13-32(2)30-19/h5,7-8,11-13,15,20H,6,9-10,14H2,1-4H3,(H,29,31)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481094
PNG
(US10906890, Example 119.0)
Show SMILES COc1cccc(c1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1C1CCOCC1
Show InChI InChI=1S/C22H27ClN6O4S/c1-14(20-24-12-17(23)13-25-20)15(2)34(30,31)28-22-27-26-21(16-5-4-6-19(11-16)32-3)29(22)18-7-9-33-10-8-18/h4-6,11-15,18H,7-10H2,1-3H3,(H,27,28)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481098
PNG
(US10906890, Example 123.0)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H31ClN6O5S/c1-15(2)35-20(21-25-11-18(24)12-26-21)16(3)36(31,32)29-23-28-27-22(17-9-7-6-8-10-17)30(23)19(13-33-4)14-34-5/h6-12,15-16,19-20H,13-14H2,1-5H3,(H,28,29)/t16-,20+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481099
PNG
(US10906890, Example 124.0)
Show SMILES COC[C@@H](C)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C20H25ClN6O4S/c1-13(12-30-3)27-19(15-8-6-5-7-9-15)24-25-20(27)26-32(28,29)14(2)17(31-4)18-22-10-16(21)11-23-18/h5-11,13-14,17H,12H2,1-4H3,(H,25,26)/t13-,14+,17+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480996
PNG
(US10906890, Example 5.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H26N8O4S/c1-14-11-24-19(25-12-14)15(2)16(3)36(32,33)30-23-29-28-20(17-9-7-6-8-10-17)31(23)18-21(34-4)26-13-27-22(18)35-5/h6-13,15-16H,1-5H3,(H,29,30)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481011
PNG
(US10906890, Example 20.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C22H24N8O5S/c1-13-10-23-18(24-11-13)17(31)14(2)36(32,33)29-22-28-27-19(15-8-6-5-7-9-15)30(22)16-20(34-3)25-12-26-21(16)35-4/h5-12,14,17,31H,1-4H3,(H,28,29)/t14-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481016
PNG
(US10906890, Example 25.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H28N6O4S/c1-16-14-27-20(15-26-16)17(2)18(3)36(32,33)30-25-29-28-24(19-10-7-6-8-11-19)31(25)23-21(34-4)12-9-13-22(23)35-5/h6-15,17-18H,1-5H3,(H,29,30)/t17-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481026
PNG
(US10906890, Example 35.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H26ClN7O4S/c1-36-20-11-6-12-21(37-2)22(20)33-23(17-8-4-3-5-9-17)29-30-25(33)31-38(34,35)19-10-7-13-32(16-19)24-27-14-18(26)15-28-24/h3-6,8-9,11-12,14-15,19H,7,10,13,16H2,1-2H3,(H,30,31)/t19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481038
PNG
(US10906890, Example 49.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N8O4S/c1-13-10-29-18(11-28-13)14(2)15(3)40(36,37)34-23-33-32-20(16-7-6-8-17(9-16)24(25,26)27)35(23)19-21(38-4)30-12-31-22(19)39-5/h6-12,14-15H,1-5H3,(H,33,34)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481041
PNG
(US10906890, Example 53.0 | US10906890, Example 56....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@@H](O)CN(C2)c2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H26FN7O5S/c1-37-20-9-6-10-21(38-2)22(20)33-23(16-7-4-3-5-8-16)29-30-25(33)31-39(35,36)19-11-18(34)14-32(15-19)24-27-12-17(26)13-28-24/h3-10,12-13,18-19,34H,11,14-15H2,1-2H3,(H,30,31)/t18-,19+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481048
PNG
(US10906890, Example 60.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)c2cncc(Br)c2)nnc1-c1ccccc1
Show InChI InChI=1S/C21H18BrN5O4S/c1-30-17-9-6-10-18(31-2)19(17)27-20(14-7-4-3-5-8-14)24-25-21(27)26-32(28,29)16-11-15(22)12-23-13-16/h3-13H,1-2H3,(H,25,26)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481066
PNG
(US10906890, Example 78.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)cc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H30N6O5S/c1-16-10-12-19(13-11-16)25-29-30-26(32(25)22-20(35-4)8-7-9-21(22)36-5)31-38(33,34)18(3)23(37-6)24-27-14-17(2)15-28-24/h7-15,18,23H,1-6H3,(H,30,31)/t18-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481068
PNG
(US10906890, Example 80.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc3OCCc3c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H30N6O6S/c1-16-14-28-25(29-15-16)24(38-5)17(2)40(34,35)32-27-31-30-26(19-9-10-20-18(13-19)11-12-39-20)33(27)23-21(36-3)7-6-8-22(23)37-4/h6-10,13-15,17,24H,11-12H2,1-5H3,(H,31,32)/t17-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481070
PNG
(US10906890, Example 82.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(Oc3ccccc3)cc2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C31H32N6O6S/c1-20-18-32-29(33-19-20)28(42-5)21(2)44(38,39)36-31-35-34-30(37(31)27-25(40-3)12-9-13-26(27)41-4)22-14-16-24(17-15-22)43-23-10-7-6-8-11-23/h6-19,21,28H,1-5H3,(H,35,36)/t21-,28-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481101
PNG
(US10906890, Example 127.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ccc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H24ClN7O4S/c1-14(18-11-10-17(24)12-25-18)15(2)36(32,33)30-23-29-28-20(16-8-6-5-7-9-16)31(23)19-21(34-3)26-13-27-22(19)35-4/h5-15H,1-4H3,(H,29,30)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480997
PNG
(US10906890, Example 6.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)c2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H28N8O6S/c1-14-11-25-20(26-12-14)19(36-4)15(2)39(33,34)31-24-30-29-21(16-8-7-9-17(10-16)35-3)32(24)18-22(37-5)27-13-28-23(18)38-6/h7-13,15,19H,1-6H3,(H,30,31)/t15-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481024
PNG
(US10906890, Example 33.0)
Show SMILES CO[C@@H]1CCC[C@H](OC)[C@H]1n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H34N6O4S/c1-16-14-26-23(27-15-16)17(2)18(3)36(32,33)30-25-29-28-24(19-10-7-6-8-11-19)31(25)22-20(34-4)12-9-13-21(22)35-5/h6-8,10-11,14-15,17-18,20-22H,9,12-13H2,1-5H3,(H,29,30)/t17-,18-,20-,21+,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481029
PNG
(US10906890, Example 40.0)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F)c1ncc(C)cn1
Show InChI InChI=1S/C23H22F2N6O2S/c1-14-12-26-21(27-13-14)15(2)16(3)34(32,33)30-23-29-28-22(17-8-5-4-6-9-17)31(23)20-18(24)10-7-11-19(20)25/h4-13,15-16H,1-3H3,(H,29,30)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481030
PNG
(US10906890, Example 41.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F)c1ncc(C)cn1
Show InChI InChI=1S/C23H22F2N6O3S/c1-14-12-26-21(27-13-14)20(34-3)15(2)35(32,33)30-23-29-28-22(16-8-5-4-6-9-16)31(23)19-17(24)10-7-11-18(19)25/h4-13,15,20H,1-3H3,(H,29,30)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481031
PNG
(US10906890, Example 42.0)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F)c1ncc(C)cn1
Show InChI InChI=1S/C25H26F2N6O3S/c1-15(2)36-22(23-28-13-16(3)14-29-23)17(4)37(34,35)32-25-31-30-24(18-9-6-5-7-10-18)33(25)21-19(26)11-8-12-20(21)27/h5-15,17,22H,1-4H3,(H,31,32)/t17-,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481036
PNG
(US10906890, Example 47.0)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F)c1ncc(cn1)C#N
Show InChI InChI=1S/C23H19F2N7O2S/c1-14(21-27-12-16(11-26)13-28-21)15(2)35(33,34)31-23-30-29-22(17-7-4-3-5-8-17)32(23)20-18(24)9-6-10-19(20)25/h3-10,12-15H,1-2H3,(H,30,31)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481046
PNG
(US10906890, Example 58.0 | US10906890, Example 59....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@H](CN(C2)c2ncc(F)cn2)OC(C)C)nnc1-c1ccccc1
Show InChI InChI=1S/C28H32FN7O5S/c1-18(2)41-21-13-22(17-35(16-21)27-30-14-20(29)15-31-27)42(37,38)34-28-33-32-26(19-9-6-5-7-10-19)36(28)25-23(39-3)11-8-12-24(25)40-4/h5-12,14-15,18,21-22H,13,16-17H2,1-4H3,(H,33,34)/t21-,22+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481050
PNG
(US10906890, Example 62.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1C1CCOCC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN6O4S/c1-14(18(31-2)19-23-12-16(22)13-24-19)33(29,30)27-21-26-25-20(15-6-4-3-5-7-15)28(21)17-8-10-32-11-9-17/h3-7,12-14,17-18H,8-11H2,1-2H3,(H,26,27)/t14-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481061
PNG
(US10906890, Example 73.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(c2)S(=O)(=O)N(C)C)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H33N7O7S2/c1-17-15-28-25(29-16-17)24(41-7)18(2)42(35,36)32-27-31-30-26(19-10-8-11-20(14-19)43(37,38)33(3)4)34(27)23-21(39-5)12-9-13-22(23)40-6/h8-16,18,24H,1-7H3,(H,31,32)/t18-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481075
PNG
(US10906890, Example 87.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(Cl)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H27ClN6O5S/c1-15-13-27-23(28-14-15)22(37-5)16(2)38(33,34)31-25-30-29-24(17-8-6-9-18(26)12-17)32(25)21-19(35-3)10-7-11-20(21)36-4/h6-14,16,22H,1-5H3,(H,30,31)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481076
PNG
(US10906890, Example 88.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(c2)[C@](C)(O)C(F)(F)F)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H31F3N6O6S/c1-16-14-32-24(33-15-16)23(43-6)17(2)44(39,40)36-26-35-34-25(37(26)22-20(41-4)11-8-12-21(22)42-5)18-9-7-10-19(13-18)27(3,38)28(29,30)31/h7-15,17,23,38H,1-6H3,(H,35,36)/t17-,23-,27-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481077
PNG
(US10906890, Example 89.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC(F)(F)F)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H27F3N6O6S/c1-15-13-30-23(31-14-15)22(40-5)16(2)42(36,37)34-25-33-32-24(17-8-6-9-18(12-17)41-26(27,28)29)35(25)21-19(38-3)10-7-11-20(21)39-4/h6-14,16,22H,1-5H3,(H,33,34)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481080
PNG
(US10906890, Example 92.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3cn(C)nc23)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H30N8O5S/c1-16-13-28-25(29-14-16)24(40-6)17(2)41(36,37)33-27-31-30-26(19-10-7-9-18-15-34(3)32-22(18)19)35(27)23-20(38-4)11-8-12-21(23)39-5/h7-15,17,24H,1-6H3,(H,31,33)/t17-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481087
PNG
(US10906890, Example 99.0)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1C1(C)CC1)c1ncc(C)cn1
Show InChI InChI=1S/C23H30N6O3S/c1-15(2)32-19(20-24-13-16(3)14-25-20)17(4)33(30,31)28-22-27-26-21(18-9-7-6-8-10-18)29(22)23(5)11-12-23/h6-10,13-15,17,19H,11-12H2,1-5H3,(H,27,28)/t17-,19+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481103
PNG
(US10906890, Example 129.0)
Show SMILES COCCn1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C19H23ClN6O4S/c1-13(16(30-3)17-21-11-15(20)12-22-17)31(27,28)25-19-24-23-18(26(19)9-10-29-2)14-7-5-4-6-8-14/h4-8,11-13,16H,9-10H2,1-3H3,(H,24,25)/t13-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM480998
PNG
(US10906890, Example 7.0 | US10906890, Example 8.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H23FN6O4S/c1-15(12-20-25-13-17(24)14-26-20)35(31,32)29-23-28-27-22(16-8-5-4-6-9-16)30(23)21-18(33-2)10-7-11-19(21)34-3/h4-11,13-15H,12H2,1-3H3,(H,28,29)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481000
PNG
(US10906890, Example 11.0 | US10906890, Example 9.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C21H21FN8O4S/c1-13(9-16-23-10-15(22)11-24-16)35(31,32)29-21-28-27-18(14-7-5-4-6-8-14)30(21)17-19(33-2)25-12-26-20(17)34-3/h4-8,10-13H,9H2,1-3H3,(H,28,29)/t13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481006
PNG
(US10906890, Example 15.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H28N6O4S/c1-16-14-26-23(27-15-16)17(2)18(3)36(32,33)30-25-29-28-24(19-10-7-6-8-11-19)31(25)22-20(34-4)12-9-13-21(22)35-5/h6-15,17-18H,1-5H3,(H,29,30)/t17-,18-/m0/s1
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n/an/an/an/a 0.890n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481014
PNG
(US10906890, Example 23.0 | US10906890, Example 24....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H27N7O5S/c1-15-13-26-21(27-14-15)20(35-4)16(2)37(32,33)30-24-29-28-22(17-9-7-6-8-10-17)31(24)19-18(34-3)11-12-25-23(19)36-5/h6-14,16,20H,1-5H3,(H,29,30)/t16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481017
PNG
(US10906890, Example 26.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H26N8O4S/c1-14-11-25-18(12-24-14)15(2)16(3)36(32,33)30-23-29-28-20(17-9-7-6-8-10-17)31(23)19-21(34-4)26-13-27-22(19)35-5/h6-13,15-16H,1-5H3,(H,29,30)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481018
PNG
(US10906890, Example 27.0 | US10906890, Example 28....)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C23H24FN9O4S/c1-36-20-18(21(37-2)28-14-27-20)33-19(15-7-4-3-5-8-15)29-30-23(33)31-38(34,35)17-9-6-10-32(13-17)22-25-11-16(24)12-26-22/h3-5,7-8,11-12,14,17H,6,9-10,13H2,1-2H3,(H,30,31)/t17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481027
PNG
(US10906890, Example 36.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H27N7O5S/c1-15-13-26-21(27-14-15)20(35-4)16(2)37(32,33)30-24-29-28-22(17-9-7-6-8-10-17)31(24)19-18(34-3)11-12-25-23(19)36-5/h6-14,16,20H,1-5H3,(H,29,30)/t16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481035
PNG
(US10906890, Example 46.0)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H19ClF2N6O2S/c1-13(20-26-11-16(23)12-27-20)14(2)34(32,33)30-22-29-28-21(15-7-4-3-5-8-15)31(22)19-17(24)9-6-10-18(19)25/h3-14H,1-2H3,(H,29,30)/t13-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481041
PNG
(US10906890, Example 53.0 | US10906890, Example 56....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@@H](O)CN(C2)c2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H26FN7O5S/c1-37-20-9-6-10-21(38-2)22(20)33-23(16-7-4-3-5-8-16)29-30-25(33)31-39(35,36)19-11-18(34)14-32(15-19)24-27-12-17(26)13-28-24/h3-10,12-13,18-19,34H,11,14-15H2,1-2H3,(H,30,31)/t18-,19+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481053
PNG
(US10906890, Example 65.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(cc2)C(C)(C)C)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C29H36N6O5S/c1-18-16-30-26(31-17-18)25(40-8)19(2)41(36,37)34-28-33-32-27(20-12-14-21(15-13-20)29(3,4)5)35(28)24-22(38-6)10-9-11-23(24)39-7/h9-17,19,25H,1-8H3,(H,33,34)/t19-,25-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481059
PNG
(US10906890, Example 71.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(Cl)cc2Cl)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H26Cl2N6O5S/c1-14-12-28-23(29-13-14)22(38-5)15(2)39(34,35)32-25-31-30-24(17-10-9-16(26)11-18(17)27)33(25)21-19(36-3)7-6-8-20(21)37-4/h6-13,15,22H,1-5H3,(H,31,32)/t15-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481073
PNG
(US10906890, Example 85.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)N\C(NNC(=O)c1cccc(F)c1)=N/c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29FN6O6S/c1-15-13-27-23(28-14-15)22(38-5)16(2)39(34,35)32-25(29-21-19(36-3)10-7-11-20(21)37-4)31-30-24(33)17-8-6-9-18(26)12-17/h6-14,16,22H,1-5H3,(H,30,33)(H2,29,31,32)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481074
PNG
(US10906890, Example 86.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(c2)C#N)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H27N7O5S/c1-16-14-28-24(29-15-16)23(38-5)17(2)39(34,35)32-26-31-30-25(19-9-6-8-18(12-19)13-27)33(26)22-20(36-3)10-7-11-21(22)37-4/h6-12,14-15,17,23H,1-5H3,(H,31,32)/t17-,23-/m0/s1
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n/an/an/an/a 10.6n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481088
PNG
(US10906890, Example 110.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H23ClN6O3S/c1-12(2)26-18(14-8-6-5-7-9-14)23-24-19(26)25-30(27,28)13(3)16(29-4)17-21-10-15(20)11-22-17/h5-13,16H,1-4H3,(H,24,25)/t13-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481091
PNG
(US10906890, Example 116.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3nn(C)cc23)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN8O3S/c1-12(2)30-20(15-7-6-8-17-16(15)11-29(4)27-17)25-26-21(30)28-34(31,32)13(3)18(33-5)19-23-9-14(22)10-24-19/h6-13,18H,1-5H3,(H,26,28)/t13-,18-/m0/s1
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n/an/an/an/a 220n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481001
PNG
(US10906890, Example 10.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cc2C#N)nnc1-c1ccccc1
Show InChI InChI=1S/C23H20FN7O4S/c1-34-21-19(22(35-2)27-14-26-21)31-20(16-6-4-3-5-7-16)28-29-23(31)30-36(32,33)11-10-15-8-9-18(24)12-17(15)13-25/h3-9,12,14H,10-11H2,1-2H3,(H,29,30)
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n/an/an/an/a 42n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481003
PNG
(US10906890, Example 12.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cc2C#N)nnc1-c1ccccc1
Show InChI InChI=1S/C25H22FN5O4S/c1-34-21-9-6-10-22(35-2)23(21)31-24(18-7-4-3-5-8-18)28-29-25(31)30-36(32,33)14-13-17-11-12-20(26)15-19(17)16-27/h3-12,15H,13-14H2,1-2H3,(H,29,30)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481005
PNG
(US10906890, Example 14.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H30N8O5S/c1-15(2)38-20(21-26-12-16(3)13-27-21)17(4)39(34,35)32-25-31-30-22(18-10-8-7-9-11-18)33(25)19-23(36-5)28-14-29-24(19)37-6/h7-15,17,20H,1-6H3,(H,31,32)/t17-,20+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481012
PNG
(US10906890, Example 21.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(F)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C25H26FN7O4S/c1-36-20-11-6-12-21(37-2)22(20)33-23(17-8-4-3-5-9-17)29-30-25(33)31-38(34,35)19-10-7-13-32(16-19)24-27-14-18(26)15-28-24/h3-6,8-9,11-12,14-15,19H,7,10,13,16H2,1-2H3,(H,30,31)/t19-/m0/s1
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n/an/an/an/a 7.30n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481014
PNG
(US10906890, Example 23.0 | US10906890, Example 24....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H27N7O5S/c1-15-13-26-21(27-14-15)20(35-4)16(2)37(32,33)30-24-29-28-22(17-9-7-6-8-10-17)31(24)19-18(34-3)11-12-25-23(19)36-5/h6-14,16,20H,1-5H3,(H,29,30)/t16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481032
PNG
(US10906890, Example 43.0)
Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(F)cccc1F)c1cnc(C)cn1
Show InChI InChI=1S/C23H22F2N6O2S/c1-14-12-27-20(13-26-14)15(2)16(3)34(32,33)30-23-29-28-22(17-8-5-4-6-9-17)31(23)21-18(24)10-7-11-19(21)25/h4-13,15-16H,1-3H3,(H,29,30)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481042
PNG
(US10906890, Example 54.0 | US10906890, Example 55....)
Show SMILES COc1ccnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C24H27N7O4S/c1-15-13-27-19(14-26-15)16(2)17(3)36(32,33)30-24-29-28-22(18-9-7-6-8-10-18)31(24)21-20(34-4)11-12-25-23(21)35-5/h6-14,16-17H,1-5H3,(H,29,30)/t16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481046
PNG
(US10906890, Example 58.0 | US10906890, Example 59....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@H](CN(C2)c2ncc(F)cn2)OC(C)C)nnc1-c1ccccc1
Show InChI InChI=1S/C28H32FN7O5S/c1-18(2)41-21-13-22(17-35(16-21)27-30-14-20(29)15-31-27)42(37,38)34-28-33-32-26(19-9-6-5-7-10-19)36(28)25-23(39-3)11-8-12-24(25)40-4/h5-12,14-15,18,21-22H,13,16-17H2,1-4H3,(H,33,34)/t21-,22+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481067
PNG
(US10906890, Example 79.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cc(OC)ccc2OC)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C27H32N6O7S/c1-16-14-28-25(29-15-16)24(40-7)17(2)41(34,35)32-27-31-30-26(19-13-18(36-3)11-12-20(19)37-4)33(27)23-21(38-5)9-8-10-22(23)39-6/h8-15,17,24H,1-7H3,(H,31,32)/t17-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481069
PNG
(US10906890, Example 81.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(Br)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H27BrN6O5S/c1-15-13-27-23(28-14-15)22(37-5)16(2)38(33,34)31-25-30-29-24(17-8-6-9-18(26)12-17)32(25)21-19(35-3)10-7-11-20(21)36-4/h6-14,16,22H,1-5H3,(H,30,31)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481081
PNG
(US10906890, Example 93.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3cn(C)nc23)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H28N10O5S/c1-14-10-26-21(27-11-14)20(38-4)15(2)41(36,37)33-25-31-30-22(17-9-7-8-16-12-34(3)32-18(16)17)35(25)19-23(39-5)28-13-29-24(19)40-6/h7-13,15,20H,1-6H3,(H,31,33)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481083
PNG
(US10906890, Example 95.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc3cnccc23)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H29N7O5S/c1-17-14-30-26(31-15-17)25(40-5)18(2)41(36,37)34-28-33-32-27(21-9-6-8-19-16-29-13-12-20(19)21)35(28)24-22(38-3)10-7-11-23(24)39-4/h6-16,18,25H,1-5H3,(H,33,34)/t18-,25-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481097
PNG
(US10906890, Example 122.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC(F)F)c2)n1C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H21ClF2N6O4S/c1-11(16(32-2)17-24-9-13(21)10-25-17)34(30,31)28-20-27-26-18(29(20)14-6-7-14)12-4-3-5-15(8-12)33-19(22)23/h3-5,8-11,14,16,19H,6-7H2,1-2H3,(H,27,28)/t11-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM481100
PNG
(US10906890, Example 126.0)
Show SMILES COC[C@H](C)n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1ccccc1
Show InChI InChI=1S/C20H25ClN6O3S/c1-13(12-30-4)27-19(16-8-6-5-7-9-16)24-25-20(27)26-31(28,29)15(3)14(2)18-22-10-17(21)11-23-18/h5-11,13-15H,12H2,1-4H3,(H,25,26)/t13-,14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US10906890 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%