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Patent code US10913753

Compile Data Set for Download or QSAR

Found 410 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM482065
PNG
(US10913753, Compound I-132)
Show SMILES C[C@@H]1CNCCN1c1ccc(CCNC(=O)c2sc3nc(C)ccc3c2N)cc1
Show InChI InChI=1S/C22H27N5OS/c1-14-3-8-18-19(23)20(29-22(18)26-14)21(28)25-10-9-16-4-6-17(7-5-16)27-12-11-24-13-15(27)2/h3-8,15,24H,9-13,23H2,1-2H3,(H,25,28)/t15-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482066
PNG
(US10913753, Compound I-133)
Show SMILES C[C@H]1CNCCN1c1ccc(CCNC(=O)c2sc3nc(C)ccc3c2N)cc1
Show InChI InChI=1S/C22H27N5OS/c1-14-3-8-18-19(23)20(29-22(18)26-14)21(28)25-10-9-16-4-6-17(7-5-16)27-12-11-24-13-15(27)2/h3-8,15,24H,9-13,23H2,1-2H3,(H,25,28)/t15-/m0/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482079
PNG
(US10913753, Compound I-146)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCCC11CCCNC1
Show InChI InChI=1S/C25H31N5OS/c1-17-4-9-20-21(26)22(32-24(20)29-17)23(31)28-14-10-18-5-7-19(8-6-18)30-15-3-12-25(30)11-2-13-27-16-25/h4-9,27H,2-3,10-16,26H2,1H3,(H,28,31)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482114
PNG
(US10913753, Compound I-181)
Show SMILES Nc1c(sc2ncccc12)C(=O)NCCc1ccc(cc1)C1CCNC1
Show InChI InChI=1S/C20H22N4OS/c21-17-16-2-1-9-24-20(16)26-18(17)19(25)23-11-7-13-3-5-14(6-4-13)15-8-10-22-12-15/h1-6,9,15,22H,7-8,10-12,21H2,(H,23,25)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482127
PNG
(US10913753, Compound I-194)
Show SMILES CNc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)C1CCN(C)CC1
Show InChI InChI=1S/C23H29N5OS/c1-25-19-8-7-18-20(24)21(30-23(18)27-19)22(29)26-12-9-15-3-5-16(6-4-15)17-10-13-28(2)14-11-17/h3-8,17H,9-14,24H2,1-2H3,(H,25,27)(H,26,29)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM481935
PNG
(US10913753, Compound I-2)
Show SMILES COc1cc(ccc1CCNC(=O)c1sc2nc(C)ccc2c1N)N1CCNCC1
Show InChI InChI=1S/C22H27N5O2S/c1-14-3-6-17-19(23)20(30-22(17)26-14)21(28)25-8-7-15-4-5-16(13-18(15)29-2)27-11-9-24-10-12-27/h3-6,13,24H,7-12,23H2,1-2H3,(H,25,28)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481948
PNG
(US10913753, Compound I-15 | US10913753, Compound I...)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CC2CCC(C1)N2
Show InChI InChI=1S/C23H27N5OS/c1-14-2-9-19-20(24)21(30-23(19)26-14)22(29)25-11-10-15-3-7-18(8-4-15)28-12-16-5-6-17(13-28)27-16/h2-4,7-9,16-17,27H,5-6,10-13,24H2,1H3,(H,25,29)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM481952
PNG
(US10913753, Compound I-19)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H27N5OS/c1-16-6-8-20-22(26)23(32-25(20)29-16)24(31)28-11-10-17-7-9-21(30-14-12-27-13-15-30)19-5-3-2-4-18(17)19/h2-9,27H,10-15,26H2,1H3,(H,28,31)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481954
PNG
(US10913753, Compound I-21)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1Cl)N1CC2CCC(C1)N2
Show InChI InChI=1S/C23H26ClN5OS/c1-13-2-7-18-20(25)21(31-23(18)27-13)22(30)26-9-8-14-3-6-17(10-19(14)24)29-11-15-4-5-16(12-29)28-15/h2-3,6-7,10,15-16,28H,4-5,8-9,11-12,25H2,1H3,(H,26,30)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481968
PNG
(US10913753, Compound I-35)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(N2CCNCC2)c(F)c1F
Show InChI InChI=1S/C21H22F3N5OS/c1-11-2-3-13-17(25)19(31-21(13)28-11)20(30)27-5-4-12-10-14(22)18(16(24)15(12)23)29-8-6-26-7-9-29/h2-3,10,26H,4-9,25H2,1H3,(H,27,30)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM481980
PNG
(US10913753, Compound I-47)
Show SMILES CCc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C22H27N5OS/c1-2-16-5-8-18-19(23)20(29-22(18)26-16)21(28)25-10-9-15-3-6-17(7-4-15)27-13-11-24-12-14-27/h3-8,24H,2,9-14,23H2,1H3,(H,25,28)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM481981
PNG
(US10913753, Compound I-48)
Show SMILES CCc1ccc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(cc1F)N1CCNCC1
Show InChI InChI=1S/C22H25F2N5OS/c1-2-14-3-4-15-19(25)20(31-22(15)28-14)21(30)27-6-5-13-11-17(24)18(12-16(13)23)29-9-7-26-8-10-29/h3-4,11-12,26H,2,5-10,25H2,1H3,(H,27,30)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481991
PNG
(US10913753, Compound I-58)
Show SMILES CN1CCC(CC1)c1ccc(CCNC(=O)c2sc3nc(Cl)ccc3c2N)cc1
Show InChI InChI=1S/C22H25ClN4OS/c1-27-12-9-16(10-13-27)15-4-2-14(3-5-15)8-11-25-21(28)20-19(24)17-6-7-18(23)26-22(17)29-20/h2-7,16H,8-13,24H2,1H3,(H,25,28)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481995
PNG
(US10913753, Compound I-62)
Show SMILES Cc1cc(nc2sc(C(=O)NCCc3ccc(cc3)N3CCNCC3)c(N)c12)C(F)F
Show InChI InChI=1S/C22H25F2N5OS/c1-13-12-16(20(23)24)28-22-17(13)18(25)19(31-22)21(30)27-7-6-14-2-4-15(5-3-14)29-10-8-26-9-11-29/h2-5,12,20,26H,6-11,25H2,1H3,(H,27,30)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481948
PNG
(US10913753, Compound I-15 | US10913753, Compound I...)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CC2CCC(C1)N2
Show InChI InChI=1S/C23H27N5OS/c1-14-2-9-19-20(24)21(30-23(19)26-14)22(29)25-11-10-15-3-7-18(8-4-15)28-12-16-5-6-17(13-28)27-16/h2-4,7-9,16-17,27H,5-6,10-13,24H2,1H3,(H,25,29)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482011
PNG
(US10913753, Compound I-78)
Show SMILES CCc1cc(CCNC(=O)c2sc3nc(C)ccc3c2N)ccc1N1CCNCC1
Show InChI InChI=1S/C23H29N5OS/c1-3-17-14-16(5-7-19(17)28-12-10-25-11-13-28)8-9-26-22(29)21-20(24)18-6-4-15(2)27-23(18)30-21/h4-7,14,25H,3,8-13,24H2,1-2H3,(H,26,29)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482044
PNG
(US10913753, Compound I-111)
Show SMILES C[C@H](CNC(=O)c1sc2nc(C)c(F)cc2c1N)c1cc(F)c(cc1F)N1CC2CCC(C1)N2
Show InChI InChI=1S/C24H26F3N5OS/c1-11(8-29-23(33)22-21(28)16-6-17(25)12(2)30-24(16)34-22)15-5-19(27)20(7-18(15)26)32-9-13-3-4-14(10-32)31-13/h5-7,11,13-14,31H,3-4,8-10,28H2,1-2H3,(H,29,33)/t11-,13?,14?/m1/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM482063
PNG
(US10913753, Compound I-130)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1C[C@H]2C[C@@H]1CN2
Show InChI InChI=1S/C22H25N5OS/c1-13-2-7-18-19(23)20(29-22(18)26-13)21(28)24-9-8-14-3-5-16(6-4-14)27-12-15-10-17(27)11-25-15/h2-7,15,17,25H,8-12,23H2,1H3,(H,24,28)/t15-,17-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482113
PNG
(US10913753, Compound I-180)
Show SMILES Nc1c(sc2ncccc12)C(=O)NCCc1ccc(cc1)[C@H]1CCNC1
Show InChI InChI=1S/C20H22N4OS/c21-17-16-2-1-9-24-20(16)26-18(17)19(25)23-11-7-13-3-5-14(6-4-13)15-8-10-22-12-15/h1-6,9,15,22H,7-8,10-12,21H2,(H,23,25)/t15-/m0/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM482139
PNG
(US10913753, Compound I-206)
Show SMILES CCc1nc2sc(C(=O)NCCc3ccc(cc3)N3CCNCC3)c(N)c2cc1F
Show InChI InChI=1S/C22H26FN5OS/c1-2-18-17(23)13-16-19(24)20(30-22(16)27-18)21(29)26-8-7-14-3-5-15(6-4-14)28-11-9-25-10-12-28/h3-6,13,25H,2,7-12,24H2,1H3,(H,26,29)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481939
PNG
(US10913753, Compound I-6)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(N2CCNCC2)c(c1)C1CC1
Show InChI InChI=1S/C24H29N5OS/c1-15-2-6-18-21(25)22(31-24(18)28-15)23(30)27-9-8-16-3-7-20(19(14-16)17-4-5-17)29-12-10-26-11-13-29/h2-3,6-7,14,17,26H,4-5,8-13,25H2,1H3,(H,27,30)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481969
PNG
(US10913753, Compound I-36)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1C#N)N1CC2CCC(C1)N2
Show InChI InChI=1S/C24H26N6OS/c1-14-2-7-20-21(26)22(32-24(20)28-14)23(31)27-9-8-15-3-6-19(10-16(15)11-25)30-12-17-4-5-18(13-30)29-17/h2-3,6-7,10,17-18,29H,4-5,8-9,12-13,26H2,1H3,(H,27,31)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481970
PNG
(US10913753, Compound I-37)
Show SMILES COCc1cc(ccc1CCNC(=O)c1sc2nc(C)ccc2c1N)N1CCNCC1
Show InChI InChI=1S/C23H29N5O2S/c1-15-3-6-19-20(24)21(31-23(19)27-15)22(29)26-8-7-16-4-5-18(13-17(16)14-30-2)28-11-9-25-10-12-28/h3-6,13,25H,7-12,14,24H2,1-2H3,(H,26,29)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481974
PNG
(US10913753, Compound I-41)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1F)-n1ncc2CNCc12
Show InChI InChI=1S/C22H21FN6OS/c1-12-2-5-16-19(24)20(31-22(16)28-12)21(30)26-7-6-13-3-4-15(8-17(13)23)29-18-11-25-9-14(18)10-27-29/h2-5,8,10,25H,6-7,9,11,24H2,1H3,(H,26,30)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481977
PNG
(US10913753, Compound I-44)
Show SMILES CCc1cc(CCNC(=O)c2sc3nc(C)ccc3c2N)ccc1N1CC2CCC(C1)N2
Show InChI InChI=1S/C25H31N5OS/c1-3-17-12-16(5-9-21(17)30-13-18-6-7-19(14-30)29-18)10-11-27-24(31)23-22(26)20-8-4-15(2)28-25(20)32-23/h4-5,8-9,12,18-19,29H,3,6-7,10-11,13-14,26H2,1-2H3,(H,27,31)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481978
PNG
(US10913753, Compound I-45)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(N2CC3CCC(C2)N3)c(F)c1
Show InChI InChI=1S/C23H25F2N5OS/c1-12-2-5-16-19(26)21(32-23(16)28-12)22(31)27-7-6-13-8-17(24)20(18(25)9-13)30-10-14-3-4-15(11-30)29-14/h2,5,8-9,14-15,29H,3-4,6-7,10-11,26H2,1H3,(H,27,31)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481980
PNG
(US10913753, Compound I-47)
Show SMILES CCc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C22H27N5OS/c1-2-16-5-8-18-19(23)20(29-22(18)26-16)21(28)25-10-9-15-3-6-17(7-4-15)27-13-11-24-12-14-27/h3-8,24H,2,9-14,23H2,1H3,(H,25,28)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481982
PNG
(US10913753, Compound I-49)
Show SMILES CN[C@@H]1CCN(C1)c1cc(F)c(CCNC(=O)c2sc3nc(C)ccc3c2N)cc1F
Show InChI InChI=1S/C22H25F2N5OS/c1-12-3-4-15-19(25)20(31-22(15)28-12)21(30)27-7-5-13-9-17(24)18(10-16(13)23)29-8-6-14(11-29)26-2/h3-4,9-10,14,26H,5-8,11,25H2,1-2H3,(H,27,30)/t14-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481984
PNG
(US10913753, Compound I-51)
Show SMILES COc1ccc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(cc1F)N1CCNCC1
Show InChI InChI=1S/C21H23F2N5O2S/c1-30-17-3-2-13-18(24)19(31-21(13)27-17)20(29)26-5-4-12-10-15(23)16(11-14(12)22)28-8-6-25-7-9-28/h2-3,10-11,25H,4-9,24H2,1H3,(H,26,29)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481997
PNG
(US10913753, Compound I-64)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1C2CC1CNC2
Show InChI InChI=1S/C22H25N5OS/c1-13-2-7-18-19(23)20(29-22(18)26-13)21(28)25-9-8-14-3-5-15(6-4-14)27-16-10-17(27)12-24-11-16/h2-7,16-17,24H,8-12,23H2,1H3,(H,25,28)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482056
PNG
(US10913753, Compound I-123 | US10913753, Compound ...)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCC2(C1)CCCNC2
Show InChI InChI=1S/C25H31N5OS/c1-17-3-8-20-21(26)22(32-24(20)29-17)23(31)28-13-9-18-4-6-19(7-5-18)30-14-11-25(16-30)10-2-12-27-15-25/h3-8,27H,2,9-16,26H2,1H3,(H,28,31)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482063
PNG
(US10913753, Compound I-130)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1C[C@H]2C[C@@H]1CN2
Show InChI InChI=1S/C22H25N5OS/c1-13-2-7-18-19(23)20(29-22(18)26-13)21(28)24-9-8-14-3-5-16(6-4-14)27-12-15-10-17(27)11-25-15/h2-7,15,17,25H,8-12,23H2,1H3,(H,24,28)/t15-,17-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482068
PNG
(US10913753, Compound I-135)
Show SMILES CC(C)[C@@H]1CN(CCN1)c1ccc(CCNC(=O)c2sc3nc(C)ccc3c2N)cc1
Show InChI InChI=1S/C24H31N5OS/c1-15(2)20-14-29(13-12-26-20)18-7-5-17(6-8-18)10-11-27-23(30)22-21(25)19-9-4-16(3)28-24(19)31-22/h4-9,15,20,26H,10-14,25H2,1-3H3,(H,27,30)/t20-/m0/s1
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482102
PNG
(US10913753, Compound I-169)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(C2CCNCC2)c(F)c1
Show InChI InChI=1S/C22H25FN4OS/c1-13-2-4-17-19(24)20(29-22(17)27-13)21(28)26-11-6-14-3-5-16(18(23)12-14)15-7-9-25-10-8-15/h2-5,12,15,25H,6-11,24H2,1H3,(H,26,28)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482103
PNG
(US10913753, Compound I-170)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1F)C1CCNCC1
Show InChI InChI=1S/C22H25FN4OS/c1-13-2-5-17-19(24)20(29-22(17)27-13)21(28)26-11-8-15-3-4-16(12-18(15)23)14-6-9-25-10-7-14/h2-5,12,14,25H,6-11,24H2,1H3,(H,26,28)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482121
PNG
(US10913753, Compound I-188)
Show SMILES CCNc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C22H28N6OS/c1-2-25-18-8-7-17-19(23)20(30-22(17)27-18)21(29)26-10-9-15-3-5-16(6-4-15)28-13-11-24-12-14-28/h3-8,24H,2,9-14,23H2,1H3,(H,25,27)(H,26,29)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM481940
PNG
(US10913753, Compound I-7)
Show SMILES Cc1cc(c2c(N)c(sc2n1)C(=O)NCCc1ccc(N2CCNCC2)c(F)c1)C(F)(F)F
Show InChI InChI=1S/C22H23F4N5OS/c1-12-10-14(22(24,25)26)17-18(27)19(33-21(17)30-12)20(32)29-5-4-13-2-3-16(15(23)11-13)31-8-6-28-7-9-31/h2-3,10-11,28H,4-9,27H2,1H3,(H,29,32)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481945
PNG
(US10913753, Compound I-12)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)-c1cnn2CCNCc12
Show InChI InChI=1S/C23H24N6OS/c1-14-2-7-17-20(24)21(31-23(17)28-14)22(30)26-9-8-15-3-5-16(6-4-15)18-12-27-29-11-10-25-13-19(18)29/h2-7,12,25H,8-11,13,24H2,1H3,(H,26,30)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM481947
PNG
(US10913753, Compound I-14)
Show SMILES Cc1cc(C(F)F)c2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C22H25F2N5OS/c1-13-12-16(20(23)24)17-18(25)19(31-22(17)28-13)21(30)27-7-6-14-2-4-15(5-3-14)29-10-8-26-9-11-29/h2-5,12,20,26H,6-11,25H2,1H3,(H,27,30)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481949
PNG
(US10913753, Compound I-16)
Show SMILES Nc1c(sc2nc(N)cc(C(F)F)c12)C(=O)NCCc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C21H24F2N6OS/c22-19(23)14-11-15(24)28-21-16(14)17(25)18(31-21)20(30)27-6-5-12-1-3-13(4-2-12)29-9-7-26-8-10-29/h1-4,11,19,26H,5-10,25H2,(H2,24,28)(H,27,30)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481967
PNG
(US10913753, Compound I-34)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(cc1F)N1CC2CCC(C1)N2
Show InChI InChI=1S/C23H25F2N5OS/c1-12-2-5-16-20(26)21(32-23(16)28-12)22(31)27-7-6-13-8-18(25)19(9-17(13)24)30-10-14-3-4-15(11-30)29-14/h2,5,8-9,14-15,29H,3-4,6-7,10-11,26H2,1H3,(H,27,31)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM481985
PNG
(US10913753, Compound I-52)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(cc1F)N1C[C@@H]2C[C@H]1CN2
Show InChI InChI=1S/C22H23F2N5OS/c1-11-2-3-15-19(25)20(31-22(15)28-11)21(30)26-5-4-12-6-17(24)18(8-16(12)23)29-10-13-7-14(29)9-27-13/h2-3,6,8,13-14,27H,4-5,7,9-10,25H2,1H3,(H,26,30)/t13-,14-/m0/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482009
PNG
(US10913753, Compound I-76)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1Cl)N1CCNCC1
Show InChI InChI=1S/C21H24ClN5OS/c1-13-2-5-16-18(23)19(29-21(16)26-13)20(28)25-7-6-14-3-4-15(12-17(14)22)27-10-8-24-9-11-27/h2-5,12,24H,6-11,23H2,1H3,(H,25,28)
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM482015
PNG
(US10913753, Compound I-82)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1-c1ccccc1)N1CCNCC1
Show InChI InChI=1S/C27H29N5OS/c1-18-7-10-22-24(28)25(34-27(22)31-18)26(33)30-12-11-20-8-9-21(32-15-13-29-14-16-32)17-23(20)19-5-3-2-4-6-19/h2-10,17,29H,11-16,28H2,1H3,(H,30,33)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482029
PNG
(US10913753, Compound I-96)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(cc1F)N1C[C@H]2CCN[C@H]2C1
Show InChI InChI=1S/C23H25F2N5OS/c1-12-2-3-15-20(26)21(32-23(15)29-12)22(31)28-7-4-13-8-17(25)19(9-16(13)24)30-10-14-5-6-27-18(14)11-30/h2-3,8-9,14,18,27H,4-7,10-11,26H2,1H3,(H,28,31)/t14-,18+/m1/s1
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482067
PNG
(US10913753, Compound I-134)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(CCNC(=O)c2sc3nc(C)ccc3c2N)cc1
Show InChI InChI=1S/C22H27N5OS/c1-14-3-8-18-19(23)20(29-22(18)26-14)21(28)25-10-9-16-4-6-17(7-5-16)27-12-11-24-15(2)13-27/h3-8,15,24H,9-13,23H2,1-2H3,(H,25,28)/t15-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482073
PNG
(US10913753, Compound I-140)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCC2(CNC2)CC1
Show InChI InChI=1S/C24H29N5OS/c1-16-2-7-19-20(25)21(31-23(19)28-16)22(30)27-11-8-17-3-5-18(6-4-17)29-12-9-24(10-13-29)14-26-15-24/h2-7,26H,8-15,25H2,1H3,(H,27,30)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482077
PNG
(US10913753, Compound I-144)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCCC2(CCNCC2)C1
Show InChI InChI=1S/C26H33N5OS/c1-18-3-8-21-22(27)23(33-25(21)30-18)24(32)29-13-9-19-4-6-20(7-5-19)31-16-2-10-26(17-31)11-14-28-15-12-26/h3-8,28H,2,9-17,27H2,1H3,(H,29,32)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 25


(Homo sapiens)
BDBM482137
PNG
(US10913753, Compound I-204)
Show SMILES Cc1cc(c2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)N1CCNCC1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5OS/c1-13-12-16(22(23,24)25)17-18(26)19(32-21(17)29-13)20(31)28-7-6-14-2-4-15(5-3-14)30-10-8-27-9-11-30/h2-5,12,27H,6-11,26H2,1H3,(H,28,31)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 28


(Homo sapiens)
BDBM482138
PNG
(US10913753, Compound I-205)
Show SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(C2CCNCC2)c(Cl)c1
Show InChI InChI=1S/C22H25ClN4OS/c1-13-2-4-17-19(24)20(29-22(17)27-13)21(28)26-11-6-14-3-5-16(18(23)12-14)15-7-9-25-10-8-15/h2-5,12,15,25H,6-11,24H2,1H3,(H,26,28)
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VALO EARLY DISCOVERY, INC.

US Patent


Assay Description
USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...


US Patent US10913753 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%