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Patent code US10919843

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482300
PNG
(US10919843, Compound IX)
Show SMILES CCCCCC1=C(NCC(C)(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C26H39NO3/c1-8-9-10-11-19-22(27-15-26(5,6)7)24(29)21(25(30)23(19)28)20-14-17(4)12-13-18(20)16(2)3/h14,18,20,27,30H,2,8-13,15H2,1,3-7H3/t18-,20+/m0/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482299
PNG
(US10919843, Compound VIII)
Show SMILES CCCCCC1=C(NCc2ccccc2)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C28H35NO3/c1-5-6-8-13-22-25(29-17-20-11-9-7-10-12-20)27(31)24(28(32)26(22)30)23-16-19(4)14-15-21(23)18(2)3/h7,9-12,16,21,23,29,32H,2,5-6,8,13-15,17H2,1,3-4H3/t21-,23+/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482298
PNG
(US10919843, Compound VII)
Show SMILES CCCCCC1=C(NC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C24H35NO3/c1-7-8-9-10-18-21(25-15(4)5)23(27)20(24(28)22(18)26)19-13-16(6)11-12-17(19)14(2)3/h13,15,17,19,25,28H,2,7-12H2,1,3-6H3/t17-,19+/m0/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482301
PNG
(US10919843, Compound X)
Show SMILES CCCCCC1=C(NCCC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C26H39NO3/c1-7-8-9-10-20-23(27-14-13-16(2)3)25(29)22(26(30)24(20)28)21-15-18(6)11-12-19(21)17(4)5/h15-16,19,21,27,30H,4,7-14H2,1-3,5-6H3/t19-,21+/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482298
PNG
(US10919843, Compound VII)
Show SMILES CCCCCC1=C(NC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C24H35NO3/c1-7-8-9-10-18-21(25-15(4)5)23(27)20(24(28)22(18)26)19-13-16(6)11-12-17(19)14(2)3/h13,15,17,19,25,28H,2,7-12H2,1,3-6H3/t17-,19+/m0/s1
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n/an/an/an/a 2.90E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482300
PNG
(US10919843, Compound IX)
Show SMILES CCCCCC1=C(NCC(C)(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C26H39NO3/c1-8-9-10-11-19-22(27-15-26(5,6)7)24(29)21(25(30)23(19)28)20-14-17(4)12-13-18(20)16(2)3/h14,18,20,27,30H,2,8-13,15H2,1,3-7H3/t18-,20+/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482296
PNG
(US10919843, Compound V)
Show SMILES CCCCCC1=C(NCCCC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C25H37NO3/c1-6-8-10-11-19-22(26-14-9-7-2)24(28)21(25(29)23(19)27)20-15-17(5)12-13-18(20)16(3)4/h15,18,20,26,29H,3,6-14H2,1-2,4-5H3/t18-,20+/m0/s1
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n/an/an/an/a 1.80E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482294
PNG
(US10919843, Compound III)
Show SMILES CCCCCNC1=C(CCCCC)C(=O)C(O)=C([C@@H]2C=C(C)CC[C@H]2C(C)=C)C1=O
Show InChI InChI=1S/C26H39NO3/c1-6-8-10-12-20-23(27-15-11-9-7-2)25(29)22(26(30)24(20)28)21-16-18(5)13-14-19(21)17(3)4/h16,19,21,27,30H,3,6-15H2,1-2,4-5H3/t19-,21+/m0/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482299
PNG
(US10919843, Compound VIII)
Show SMILES CCCCCC1=C(NCc2ccccc2)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C28H35NO3/c1-5-6-8-13-22-25(29-17-20-11-9-7-10-12-20)27(31)24(28(32)26(22)30)23-16-19(4)14-15-21(23)18(2)3/h7,9-12,16,21,23,29,32H,2,5-6,8,13-15,17H2,1,3-4H3/t21-,23+/m0/s1
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n/an/an/an/a 2.60E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482295
PNG
(US10919843, Compound IV)
Show SMILES CCCCCC1=C(NCC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C25H37NO3/c1-7-8-9-10-19-22(26-14-15(2)3)24(28)21(25(29)23(19)27)20-13-17(6)11-12-18(20)16(4)5/h13,15,18,20,26,29H,4,7-12,14H2,1-3,5-6H3/t18-,20+/m0/s1
PDB

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n/an/an/an/a 1.60E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482293
PNG
(US10919843, Compound II)
Show SMILES CCCCCC1=C(NCC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C23H33NO3/c1-6-8-9-10-17-20(24-7-2)22(26)19(23(27)21(17)25)18-13-15(5)11-12-16(18)14(3)4/h13,16,18,24,27H,3,6-12H2,1-2,4-5H3/t16-,18+/m0/s1
PDB

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n/an/an/an/a 3.20E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482297
PNG
(US10919843, Compound VI)
Show SMILES CCCCCC1=C(NC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C22H31NO3/c1-6-7-8-9-16-19(23-5)21(25)18(22(26)20(16)24)17-12-14(4)10-11-15(17)13(2)3/h12,15,17,23,26H,2,6-11H2,1,3-5H3/t15-,17+/m0/s1
PDB

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n/an/an/an/a 4.00E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482294
PNG
(US10919843, Compound III)
Show SMILES CCCCCNC1=C(CCCCC)C(=O)C(O)=C([C@@H]2C=C(C)CC[C@H]2C(C)=C)C1=O
Show InChI InChI=1S/C26H39NO3/c1-6-8-10-12-20-23(27-15-11-9-7-2)25(29)22(26(30)24(20)28)21-16-18(5)13-14-19(21)17(3)4/h16,19,21,27,30H,3,6-15H2,1-2,4-5H3/t19-,21+/m0/s1
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n/an/an/an/a 3.60E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482296
PNG
(US10919843, Compound V)
Show SMILES CCCCCC1=C(NCCCC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C25H37NO3/c1-6-8-10-11-19-22(26-14-9-7-2)24(28)21(25(29)23(19)27)20-15-17(5)12-13-18(20)16(3)4/h15,18,20,26,29H,3,6-14H2,1-2,4-5H3/t18-,20+/m0/s1
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n/an/an/an/a 1.90E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482295
PNG
(US10919843, Compound IV)
Show SMILES CCCCCC1=C(NCC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C25H37NO3/c1-7-8-9-10-19-22(26-14-15(2)3)24(28)21(25(29)23(19)27)20-13-17(6)11-12-18(20)16(4)5/h13,15,18,20,26,29H,4,7-12,14H2,1-3,5-6H3/t18-,20+/m0/s1
PDB

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n/an/an/an/a 3.20E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482293
PNG
(US10919843, Compound II)
Show SMILES CCCCCC1=C(NCC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C23H33NO3/c1-6-8-9-10-17-20(24-7-2)22(26)19(23(27)21(17)25)18-13-15(5)11-12-16(18)14(3)4/h13,16,18,24,27H,3,6-12H2,1-2,4-5H3/t16-,18+/m0/s1
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n/an/an/an/a 4.30E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482297
PNG
(US10919843, Compound VI)
Show SMILES CCCCCC1=C(NC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C22H31NO3/c1-6-7-8-9-16-19(23-5)21(25)18(22(26)20(16)24)17-12-14(4)10-11-15(17)13(2)3/h12,15,17,23,26H,2,6-11H2,1,3-5H3/t15-,17+/m0/s1
PDB

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n/an/an/an/a 2.80E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM482301
PNG
(US10919843, Compound X)
Show SMILES CCCCCC1=C(NCCC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
Show InChI InChI=1S/C26H39NO3/c1-7-8-9-10-20-23(27-14-13-16(2)3)25(29)22(26(30)24(20)28)21-15-18(6)11-12-19(21)17(4)5/h15-16,19,21,27,30H,4,7-14H2,1-3,5-6H3/t19-,21+/m0/s1
PDB

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n/an/an/an/a 3.30E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37 C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...


US Patent US10919843 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%