BindingDB logo
myBDB logout

Patent code US10919911

Compile Data Set for Download or QSAR
Found 81 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483418
PNG
(US10919911, Example 40)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3cnnn3CCOc12
Show InChI InChI=1S/C24H21FN6O2/c1-14-9-18(25)17(10-21(14)30-12-20(26-13-30)15-5-6-15)24(32)28-19-4-2-3-16-22-11-27-29-31(22)7-8-33-23(16)19/h2-4,9-13,15H,5-8H2,1H3,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483388
PNG
(US10919911, Example 10)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3C3(CC3)COc12
Show InChI InChI=1S/C26H23FN6O2/c1-15-9-19(27)18(10-22(15)32-11-21(28-13-32)16-5-6-16)25(34)30-20-4-2-3-17-23(20)35-12-26(7-8-26)33-14-29-31-24(17)33/h2-4,9-11,13-14,16H,5-8,12H2,1H3,(H,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483415
PNG
(US10919911, Example 37)
Show SMILES CC1(C)COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C27H29N9O3/c1-27(2)15-39-24-18(25-31-32-33-36(25)27)4-3-5-19(24)30-26(37)20-12-22(35-14-21(29-16-35)17-6-7-17)23(13-28-20)34-8-10-38-11-9-34/h3-5,12-14,16-17H,6-11,15H2,1-2H3,(H,30,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483400
PNG
(US10919911, Example 22)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C26H27N9O3/c1-16-14-38-24-18(25-30-31-32-35(16)25)3-2-4-19(24)29-26(36)20-11-22(34-13-21(28-15-34)17-5-6-17)23(12-27-20)33-7-9-37-10-8-33/h2-4,11-13,15-17H,5-10,14H2,1H3,(H,29,36)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483416
PNG
(US10919911, Example 38)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C27H28N8O3/c1-17-14-38-25-19(26-32-30-16-35(17)26)3-2-4-20(25)31-27(36)21-11-23(34-13-22(29-15-34)18-5-6-18)24(12-28-21)33-7-9-37-10-8-33/h2-4,11-13,15-18H,5-10,14H2,1H3,(H,31,36)/t17-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483421
PNG
(US10919911, Example 43)
Show SMILES C[C@@H]1Cn2nnnc2-c2cccc(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)c2O1
Show InChI InChI=1S/C24H22FN7O2/c1-13-8-18(25)17(9-21(13)31-11-20(26-12-31)15-6-7-15)24(33)27-19-5-3-4-16-22(19)34-14(2)10-32-23(16)28-29-30-32/h3-5,8-9,11-12,14-15H,6-7,10H2,1-2H3,(H,27,33)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483401
PNG
(US10919911, Example 23)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@@H](CO)COc12
Show InChI InChI=1S/C24H22FN7O3/c1-13-7-18(25)17(8-21(13)31-9-20(26-12-31)14-5-6-14)24(34)27-19-4-2-3-16-22(19)35-11-15(10-33)32-23(16)28-29-30-32/h2-4,7-9,12,14-15,33H,5-6,10-11H2,1H3,(H,27,34)/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483446
PNG
(US10919911, Example 68)
Show SMILES CC(C)Oc1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C24H24N8O3/c1-14(2)35-21-11-25-18(10-20(21)31-12-19(26-13-31)15-6-7-15)24(33)27-17-5-3-4-16-22(17)34-9-8-32-23(16)28-29-30-32/h3-5,10-15H,6-9H2,1-2H3,(H,27,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483433
PNG
(US10919911, Example 55)
Show SMILES C[C@@H]1CN(CCO1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C26H27N9O3/c1-16-13-33(7-9-37-16)23-12-27-20(11-22(23)34-14-21(28-15-34)17-5-6-17)26(36)29-19-4-2-3-18-24(19)38-10-8-35-25(18)30-31-32-35/h2-4,11-12,14-17H,5-10,13H2,1H3,(H,29,36)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483448
PNG
(US10919911, Example 70)
Show SMILES C[C@@H]1COCCN1c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C26H27N9O3/c1-16-14-37-9-7-34(16)23-12-27-20(11-22(23)33-13-21(28-15-33)17-5-6-17)26(36)29-19-4-2-3-18-24(19)38-10-8-35-25(18)30-31-32-35/h2-4,11-13,15-17H,5-10,14H2,1H3,(H,29,36)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483397
PNG
(US10919911, Example 19)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C26H27N9O3/c1-16-14-38-24-18(25-30-31-32-35(16)25)3-2-4-19(24)29-26(36)20-11-22(34-13-21(28-15-34)17-5-6-17)23(12-27-20)33-7-9-37-10-8-33/h2-4,11-13,15-17H,5-10,14H2,1H3,(H,29,36)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483413
PNG
(US10919911, Example 35)
Show SMILES C[C@H]1Cn2cnnc2-c2cccc(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)c2O1
Show InChI InChI=1S/C25H23FN6O2/c1-14-8-19(26)18(9-22(14)31-11-21(27-12-31)16-6-7-16)25(33)29-20-5-3-4-17-23(20)34-15(2)10-32-13-28-30-24(17)32/h3-5,8-9,11-13,15-16H,6-7,10H2,1-2H3,(H,29,33)/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483445
PNG
(US10919911, Example 67)
Show SMILES CC1(O)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C25H25N9O3/c1-25(36)12-33(13-25)21-10-26-18(9-20(21)32-11-19(27-14-32)15-5-6-15)24(35)28-17-4-2-3-16-22(17)37-8-7-34-23(16)29-30-31-34/h2-4,9-11,14-15,36H,5-8,12-13H2,1H3,(H,28,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483441
PNG
(US10919911, Example 63)
Show SMILES CC1(O)CCN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C26H27N9O3/c1-26(37)7-8-33(14-26)22-12-27-19(11-21(22)34-13-20(28-15-34)16-5-6-16)25(36)29-18-4-2-3-17-23(18)38-10-9-35-24(17)30-31-32-35/h2-4,11-13,15-16,37H,5-10,14H2,1H3,(H,29,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483410
PNG
(US10919911, Example 32)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3[C@@H](CF)COc12
Show InChI InChI=1S/C25H22F2N6O2/c1-14-7-19(27)18(8-22(14)32-10-21(28-12-32)15-5-6-15)25(34)30-20-4-2-3-17-23(20)35-11-16(9-26)33-13-29-31-24(17)33/h2-4,7-8,10,12-13,15-16H,5-6,9,11H2,1H3,(H,30,34)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483436
PNG
(US10919911, Example 58)
Show SMILES O=C(Nc1cccc2-c3nnnn3CCOc12)c1cc(c(cn1)N1CCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H23N9O2/c34-24(27-17-4-1-3-16-22(17)35-10-9-33-23(16)28-29-30-33)18-11-20(21(12-25-18)31-7-2-8-31)32-13-19(26-14-32)15-5-6-15/h1,3-4,11-15H,2,5-10H2,(H,27,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483454
PNG
(US10919911, Example 76)
Show SMILES C[C@@H]1CN(CCO1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@@H](C)COc12
Show InChI InChI=1S/C27H29N9O3/c1-16-14-39-25-19(26-31-32-33-36(16)26)4-3-5-20(25)30-27(37)21-10-23(35-13-22(29-15-35)18-6-7-18)24(11-28-21)34-8-9-38-17(2)12-34/h3-5,10-11,13,15-18H,6-9,12,14H2,1-2H3,(H,30,37)/t16-,17+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483443
PNG
(US10919911, Example 65)
Show SMILES C[C@H]1COCCN1c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C26H27N9O3/c1-16-14-37-9-7-34(16)23-12-27-20(11-22(23)33-13-21(28-15-33)17-5-6-17)26(36)29-19-4-2-3-18-24(19)38-10-8-35-25(18)30-31-32-35/h2-4,11-13,15-17H,5-10,14H2,1H3,(H,29,36)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483403
PNG
(US10919911, Example 25)
Show SMILES O=C(Nc1cccc2-c3nncn3C3(CC3)COc12)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H28N8O3/c37-27(32-20-3-1-2-19-25(20)39-15-28(6-7-28)36-17-31-33-26(19)36)21-12-23(35-14-22(30-16-35)18-4-5-18)24(13-29-21)34-8-10-38-11-9-34/h1-3,12-14,16-18H,4-11,15H2,(H,32,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483439
PNG
(US10919911, Example 61)
Show SMILES O[C@H]1CCN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C25H25N9O3/c35-16-6-7-32(12-16)22-11-26-19(10-21(22)33-13-20(27-14-33)15-4-5-15)25(36)28-18-3-1-2-17-23(18)37-9-8-34-24(17)29-30-31-34/h1-3,10-11,13-16,35H,4-9,12H2,(H,28,36)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483428
PNG
(US10919911, Example 50)
Show SMILES O=C(Nc1cccc2-c3nnnn3CCOc12)c1cc(ccn1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C21H18N8O2/c30-21(17-10-14(6-7-22-17)28-11-18(23-12-28)13-4-5-13)24-16-3-1-2-15-19(16)31-9-8-29-20(15)25-26-27-29/h1-3,6-7,10-13H,4-5,8-9H2,(H,24,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483442
PNG
(US10919911, Example 64)
Show SMILES O=C(Nc1cccc2-c3nnnn3CCOc12)c1cc(c(cn1)N1C[C@@H]2C[C@H]1CO2)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H25N9O3/c36-26(29-19-3-1-2-18-24(19)37-7-6-35-25(18)30-31-32-35)20-9-22(33-12-21(28-14-33)15-4-5-15)23(10-27-20)34-11-17-8-16(34)13-38-17/h1-3,9-10,12,14-17H,4-8,11,13H2,(H,29,36)/t16-,17-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483453
PNG
(US10919911, Example 75)
Show SMILES C[C@@H]1CN(CCO1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@H](C)COc12
Show InChI InChI=1S/C27H29N9O3/c1-16-14-39-25-19(26-31-32-33-36(16)26)4-3-5-20(25)30-27(37)21-10-23(35-13-22(29-15-35)18-6-7-18)24(11-28-21)34-8-9-38-17(2)12-34/h3-5,10-11,13,15-18H,6-9,12,14H2,1-2H3,(H,30,37)/t16-,17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483447
PNG
(US10919911, Example 69)
Show SMILES CC(C)Oc1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@H](C)COc12
Show InChI InChI=1S/C25H26N8O3/c1-14(2)36-22-10-26-19(9-21(22)32-11-20(27-13-32)16-7-8-16)25(34)28-18-6-4-5-17-23(18)35-12-15(3)33-24(17)29-30-31-33/h4-6,9-11,13-16H,7-8,12H2,1-3H3,(H,28,34)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483411
PNG
(US10919911, Example 33)
Show SMILES FC[C@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C23H20FN7O2/c24-9-16-11-33-21-17(22-29-27-13-31(16)22)2-1-3-18(21)28-23(32)19-8-15(6-7-25-19)30-10-20(26-12-30)14-4-5-14/h1-3,6-8,10,12-14,16H,4-5,9,11H2,(H,28,32)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483407
PNG
(US10919911, Example 29)
Show SMILES FC[C@@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C23H20FN7O2/c24-9-16-11-33-21-17(22-29-27-13-31(16)22)2-1-3-18(21)28-23(32)19-8-15(6-7-25-19)30-10-20(26-12-30)14-4-5-14/h1-3,6-8,10,12-14,16H,4-5,9,11H2,(H,28,32)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483412
PNG
(US10919911, Example 34)
Show SMILES C[C@@H]1Cn2cnnc2-c2cccc(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)c2O1
Show InChI InChI=1S/C25H23FN6O2/c1-14-8-19(26)18(9-22(14)31-11-21(27-12-31)16-6-7-16)25(33)29-20-5-3-4-17-23(20)34-15(2)10-32-13-28-30-24(17)32/h3-5,8-9,11-13,15-16H,6-7,10H2,1-2H3,(H,29,33)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483392
PNG
(US10919911, Example 14)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3C3(CC3)COc12
Show InChI InChI=1S/C25H22FN7O2/c1-14-9-18(26)17(10-21(14)32-11-20(27-13-32)15-5-6-15)24(34)28-19-4-2-3-16-22(19)35-12-25(7-8-25)33-23(16)29-30-31-33/h2-4,9-11,13,15H,5-8,12H2,1H3,(H,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483437
PNG
(US10919911, Example 59)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CC3(CC3)Oc12
Show InChI InChI=1S/C25H22FN7O2/c1-14-9-18(26)17(10-21(14)32-11-20(27-13-32)15-5-6-15)24(34)28-19-4-2-3-16-22(19)35-25(7-8-25)12-33-23(16)29-30-31-33/h2-4,9-11,13,15H,5-8,12H2,1H3,(H,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483408
PNG
(US10919911, Example 30)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@H](CF)COc12
Show InChI InChI=1S/C24H21F2N7O2/c1-13-7-18(26)17(8-21(13)32-10-20(27-12-32)14-5-6-14)24(34)28-19-4-2-3-16-22(19)35-11-15(9-25)33-23(16)29-30-31-33/h2-4,7-8,10,12,14-15H,5-6,9,11H2,1H3,(H,28,34)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483406
PNG
(US10919911, Example 28)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3[C@H](CF)COc12
Show InChI InChI=1S/C25H22F2N6O2/c1-14-7-19(27)18(8-22(14)32-10-21(28-12-32)15-5-6-15)25(34)30-20-4-2-3-17-23(20)35-11-16(9-26)33-13-29-31-24(17)33/h2-4,7-8,10,12-13,15-16H,5-6,9,11H2,1H3,(H,30,34)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483390
PNG
(US10919911, Example 12)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@@H](COc12)C1CC1
Show InChI InChI=1S/C26H24FN7O2/c1-14-9-19(27)18(10-22(14)33-11-21(28-13-33)15-5-6-15)26(35)29-20-4-2-3-17-24(20)36-12-23(16-7-8-16)34-25(17)30-31-32-34/h2-4,9-11,13,15-16,23H,5-8,12H2,1H3,(H,29,35)/t23-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483435
PNG
(US10919911, Example 57)
Show SMILES O[C@@H]1CCN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C25H25N9O3/c35-16-6-7-32(12-16)22-11-26-19(10-21(22)33-13-20(27-14-33)15-4-5-15)25(36)28-18-3-1-2-17-23(18)37-9-8-34-24(17)29-30-31-34/h1-3,10-11,13-16,35H,4-9,12H2,(H,28,36)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483456
PNG
(US10919911, Example 78)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(cn3)N3CC[C@@H](O)C3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C26H27N9O3/c1-15-13-38-24-18(25-30-31-32-35(15)25)3-2-4-19(24)29-26(37)20-9-22(34-12-21(28-14-34)16-5-6-16)23(10-27-20)33-8-7-17(36)11-33/h2-4,9-10,12,14-17,36H,5-8,11,13H2,1H3,(H,29,37)/t15-,17+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483455
PNG
(US10919911, Example 77)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(c(cn3)N3CC[C@@H](O)C3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C26H27N9O3/c1-15-13-38-24-18(25-30-31-32-35(15)25)3-2-4-19(24)29-26(37)20-9-22(34-12-21(28-14-34)16-5-6-16)23(10-27-20)33-8-7-17(36)11-33/h2-4,9-10,12,14-17,36H,5-8,11,13H2,1H3,(H,29,37)/t15-,17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483426
PNG
(US10919911, Example 48)
Show SMILES C[C@H](O)[C@@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C25H24FN7O3/c1-13-8-18(26)17(9-21(13)32-10-20(27-12-32)15-6-7-15)25(35)28-19-5-3-4-16-23(19)36-11-22(14(2)34)33-24(16)29-30-31-33/h3-5,8-10,12,14-15,22,34H,6-7,11H2,1-2H3,(H,28,35)/t14-,22-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483440
PNG
(US10919911, Example 62)
Show SMILES O=C(Nc1cccc2-c3nnnn3CCOc12)c1cc(c(cn1)N1C[C@H]2C[C@@H]1CO2)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H25N9O3/c36-26(29-19-3-1-2-18-24(19)37-7-6-35-25(18)30-31-32-35)20-9-22(33-12-21(28-14-33)15-4-5-15)23(10-27-20)34-11-17-8-16(34)13-38-17/h1-3,9-10,12,14-17H,4-8,11,13H2,(H,29,36)/t16-,17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483391
PNG
(US10919911, Example 13)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3C(C)(C)COc12
Show InChI InChI=1S/C25H24FN7O2/c1-14-9-18(26)17(10-21(14)32-11-20(27-13-32)15-7-8-15)24(34)28-19-6-4-5-16-22(19)35-12-25(2,3)33-23(16)29-30-31-33/h4-6,9-11,13,15H,7-8,12H2,1-3H3,(H,28,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483394
PNG
(US10919911, Example 16)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3[C@@H](CO)COc12
Show InChI InChI=1S/C25H23FN6O3/c1-14-7-19(26)18(8-22(14)31-9-21(27-12-31)15-5-6-15)25(34)29-20-4-2-3-17-23(20)35-11-16(10-33)32-13-28-30-24(17)32/h2-4,7-9,12-13,15-16,33H,5-6,10-11H2,1H3,(H,29,34)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483423
PNG
(US10919911, Example 45)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3CC3(CC3)Oc12
Show InChI InChI=1S/C26H23FN6O2/c1-15-9-19(27)18(10-22(15)32-11-21(28-13-32)16-5-6-16)25(34)30-20-4-2-3-17-23(20)35-26(7-8-26)12-33-14-29-31-24(17)33/h2-4,9-11,13-14,16H,5-8,12H2,1H3,(H,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483449
PNG
(US10919911, Example 71)
Show SMILES CC(C)Oc1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@@H](C)COc12
Show InChI InChI=1S/C25H26N8O3/c1-14(2)36-22-10-26-19(9-21(22)32-11-20(27-13-32)16-7-8-16)25(34)28-18-6-4-5-17-23(18)35-12-15(3)33-24(17)29-30-31-33/h4-6,9-11,13-16H,7-8,12H2,1-3H3,(H,28,34)/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483389
PNG
(US10919911, Example 11)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C23H21N7O2/c1-14-11-32-21-17(22-28-26-13-30(14)22)3-2-4-18(21)27-23(31)19-9-16(7-8-24-19)29-10-20(25-12-29)15-5-6-15/h2-4,7-10,12-15H,5-6,11H2,1H3,(H,27,31)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483417
PNG
(US10919911, Example 39)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C27H28N8O3/c1-17-14-38-25-19(26-32-30-16-35(17)26)3-2-4-20(25)31-27(36)21-11-23(34-13-22(29-15-34)18-5-6-18)24(12-28-21)33-7-9-37-10-8-33/h2-4,11-13,15-18H,5-10,14H2,1H3,(H,31,36)/t17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483414
PNG
(US10919911, Example 36)
Show SMILES CC1(C)COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C28H30N8O3/c1-28(2)15-39-25-19(26-33-31-17-36(26)28)4-3-5-20(25)32-27(37)21-12-23(35-14-22(30-16-35)18-6-7-18)24(13-29-21)34-8-10-38-11-9-34/h3-5,12-14,16-18H,6-11,15H2,1-2H3,(H,32,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483387
PNG
(US10919911, Example 9)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3C(C)(C)COc12
Show InChI InChI=1S/C26H25FN6O2/c1-15-9-19(27)18(10-22(15)32-11-21(28-13-32)16-7-8-16)25(34)30-20-6-4-5-17-23(20)35-12-26(2,3)33-14-29-31-24(17)33/h4-6,9-11,13-14,16H,7-8,12H2,1-3H3,(H,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.60n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483419
PNG
(US10919911, Example 41)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3cncn3CCOc12
Show InChI InChI=1S/C25H22FN5O2/c1-15-9-19(26)18(10-22(15)31-12-21(28-14-31)16-5-6-16)25(32)29-20-4-2-3-17-23-11-27-13-30(23)7-8-33-24(17)20/h2-4,9-14,16H,5-8H2,1H3,(H,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483381
PNG
(US10919911, Example 3)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C24H22FN7O2/c1-13-8-18(25)17(9-21(13)31-10-20(26-12-31)15-6-7-15)24(33)27-19-5-3-4-16-22(19)34-11-14(2)32-23(16)28-29-30-32/h3-5,8-10,12,14-15H,6-7,11H2,1-2H3,(H,27,33)/t14-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483382
PNG
(US10919911, Example 4)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C22H20N8O2/c1-13-11-32-20-16(21-26-27-28-30(13)21)3-2-4-17(20)25-22(31)18-9-15(7-8-23-18)29-10-19(24-12-29)14-5-6-14/h2-4,7-10,12-14H,5-6,11H2,1H3,(H,25,31)/t13-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483459
PNG
(US10919911, Example 81)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3C(CF)COc12
Show InChI InChI=1S/C25H22F2N6O2/c1-14-7-19(27)18(8-22(14)32-10-21(28-12-32)15-5-6-15)25(34)30-20-4-2-3-17-23(20)35-11-16(9-26)33-13-29-31-24(17)33/h2-4,7-8,10,12-13,15-16H,5-6,9,11H2,1H3,(H,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483409
PNG
(US10919911, Example 31)
Show SMILES FC[C@@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C22H19FN8O2/c23-9-15-11-33-20-16(21-27-28-29-31(15)21)2-1-3-17(20)26-22(32)18-8-14(6-7-24-18)30-10-19(25-12-30)13-4-5-13/h1-3,6-8,10,12-13,15H,4-5,9,11H2,(H,26,32)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483458
PNG
(US10919911, Example 80)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C23H21N7O2/c1-14-11-32-21-17(22-28-26-13-30(14)22)3-2-4-18(21)27-23(31)19-9-16(7-8-24-19)29-10-20(25-12-29)15-5-6-15/h2-4,7-10,12-15H,5-6,11H2,1H3,(H,27,31)/t14-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483393
PNG
(US10919911, Example 15)
Show SMILES OCC1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C23H21N7O3/c31-10-16-11-33-21-17(22-28-26-13-30(16)22)2-1-3-18(21)27-23(32)19-8-15(6-7-24-19)29-9-20(25-12-29)14-4-5-14/h1-3,6-9,12-14,16,31H,4-5,10-11H2,(H,27,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.80n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483451
PNG
(US10919911, Example 73)
Show SMILES CC(C)Oc1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3CCOc12
Show InChI InChI=1S/C25H25N7O3/c1-15(2)35-22-11-26-19(10-21(22)32-12-20(27-13-32)16-6-7-16)25(33)29-18-5-3-4-17-23(18)34-9-8-31-14-28-30-24(17)31/h3-5,10-16H,6-9H2,1-2H3,(H,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.80n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483379
PNG
(US10919911, Example 1)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C25H23FN6O2/c1-14-8-19(26)18(9-22(14)31-10-21(27-12-31)16-6-7-16)25(33)29-20-5-3-4-17-23(20)34-11-15(2)32-13-28-30-24(17)32/h3-5,8-10,12-13,15-16H,6-7,11H2,1-2H3,(H,29,33)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.80n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483383
PNG
(US10919911, Example 5)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C24H22FN7O2/c1-13-8-18(25)17(9-21(13)31-10-20(26-12-31)15-6-7-15)24(33)27-19-5-3-4-16-22(19)34-11-14(2)32-23(16)28-29-30-32/h3-5,8-10,12,14-15H,6-7,11H2,1-2H3,(H,27,33)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.80n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483432
PNG
(US10919911, Example 54)
Show SMILES CN1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C26H28N10O2/c1-33-7-9-34(10-8-33)23-14-27-20(13-22(23)35-15-21(28-16-35)17-5-6-17)26(37)29-19-4-2-3-18-24(19)38-12-11-36-25(18)30-31-32-36/h2-4,13-17H,5-12H2,1H3,(H,29,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483427
PNG
(US10919911, Example 49 | US10919911, Example 52)
Show SMILES C[C@@H]1Cn2cnnc2-c2cccc(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)c2O1
Show InChI InChI=1S/C23H21N7O2/c1-14-10-30-13-26-28-22(30)17-3-2-4-18(21(17)32-14)27-23(31)19-9-16(7-8-24-19)29-11-20(25-12-29)15-5-6-15/h2-4,7-9,11-15H,5-6,10H2,1H3,(H,27,31)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483444
PNG
(US10919911, Example 66)
Show SMILES C[C@H]1CN(CCO1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C26H27N9O3/c1-16-13-33(7-9-37-16)23-12-27-20(11-22(23)34-14-21(28-15-34)17-5-6-17)26(36)29-19-4-2-3-18-24(19)38-10-8-35-25(18)30-31-32-35/h2-4,11-12,14-17H,5-10,13H2,1H3,(H,29,36)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483398
PNG
(US10919911, Example 20)
Show SMILES O=C(Nc1cccc2-c3nnnn3C3(CC3)COc12)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H27N9O3/c37-26(30-19-3-1-2-18-24(19)39-15-27(6-7-27)36-25(18)31-32-33-36)20-12-22(35-14-21(29-16-35)17-4-5-17)23(13-28-20)34-8-10-38-11-9-34/h1-3,12-14,16-17H,4-11,15H2,(H,30,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483399
PNG
(US10919911, Example 21)
Show SMILES O=C(Nc1cccc2-c3nnnn3CCOc12)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H25N9O3/c35-25(28-18-3-1-2-17-23(18)37-11-8-34-24(17)29-30-31-34)19-12-21(33-14-20(27-15-33)16-4-5-16)22(13-26-19)32-6-9-36-10-7-32/h1-3,12-16H,4-11H2,(H,28,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483402
PNG
(US10919911, Example 24)
Show SMILES OC[C@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C22H20N8O3/c31-10-15-11-33-20-16(21-26-27-28-30(15)21)2-1-3-17(20)25-22(32)18-8-14(6-7-23-18)29-9-19(24-12-29)13-4-5-13/h1-3,6-9,12-13,15,31H,4-5,10-11H2,(H,25,32)/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.20n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483431
PNG
(US10919911, Example 53)
Show SMILES C[C@@H](O)[C@@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C25H24FN7O3/c1-13-8-18(26)17(9-21(13)32-10-20(27-12-32)15-6-7-15)25(35)28-19-5-3-4-16-23(19)36-11-22(14(2)34)33-24(16)29-30-31-33/h3-5,8-10,12,14-15,22,34H,6-7,11H2,1-2H3,(H,28,35)/t14-,22+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483457
PNG
(US10919911, Example 79)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C23H20FN7O2/c1-13-9-17(24)16(10-20(13)30-11-19(25-12-30)14-5-6-14)23(32)26-18-4-2-3-15-21(18)33-8-7-31-22(15)27-28-29-31/h2-4,9-12,14H,5-8H2,1H3,(H,26,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.60n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483405
PNG
(US10919911, Example 27)
Show SMILES FC[C@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C22H19FN8O2/c23-9-15-11-33-20-16(21-27-28-29-31(15)21)2-1-3-17(20)26-22(32)18-8-14(6-7-24-18)30-10-19(25-12-30)13-4-5-13/h1-3,6-8,10,12-13,15H,4-5,9,11H2,(H,26,32)/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483425
PNG
(US10919911, Example 47)
Show SMILES C[C@@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2cncn12
Show InChI InChI=1S/C26H24FN5O2/c1-15-8-20(27)19(9-23(15)31-11-22(29-14-31)17-6-7-17)26(33)30-21-5-3-4-18-24-10-28-13-32(24)16(2)12-34-25(18)21/h3-5,8-11,13-14,16-17H,6-7,12H2,1-2H3,(H,30,33)/t16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483438
PNG
(US10919911, Example 60)
Show SMILES CN(C)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CCOc12
Show InChI InChI=1S/C23H23N9O2/c1-30(2)20-11-24-17(10-19(20)31-12-18(25-13-31)14-6-7-14)23(33)26-16-5-3-4-15-21(16)34-9-8-32-22(15)27-28-29-32/h3-5,10-14H,6-9H2,1-2H3,(H,26,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483384
PNG
(US10919911, Example 6)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C22H20N8O2/c1-13-11-32-20-16(21-26-27-28-30(13)21)3-2-4-17(20)25-22(31)18-9-15(7-8-23-18)29-10-19(24-12-29)14-5-6-14/h2-4,7-10,12-14H,5-6,11H2,1H3,(H,25,31)/t13-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483404
PNG
(US10919911, Example 26)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@@H](CF)COc12
Show InChI InChI=1S/C24H21F2N7O2/c1-13-7-18(26)17(8-21(13)32-10-20(27-12-32)14-5-6-14)24(34)28-19-4-2-3-16-22(19)35-11-15(9-25)33-23(16)29-30-31-33/h2-4,7-8,10,12,14-15H,5-6,9,11H2,1H3,(H,28,34)/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483385
PNG
(US10919911, Example 7)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3CCOc12
Show InChI InChI=1S/C24H21FN6O2/c1-14-9-18(25)17(10-21(14)31-11-20(26-12-31)15-5-6-15)24(32)28-19-4-2-3-16-22(19)33-8-7-30-13-27-29-23(16)30/h2-4,9-13,15H,5-8H2,1H3,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.5n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483380
PNG
(US10919911, Example 2)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2nncn12
Show InChI InChI=1S/C25H23FN6O2/c1-14-8-19(26)18(9-22(14)31-10-21(27-12-31)16-6-7-16)25(33)29-20-5-3-4-17-23(20)34-11-15(2)32-13-28-30-24(17)32/h3-5,8-10,12-13,15-16H,6-7,11H2,1-2H3,(H,29,33)/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.10n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483395
PNG
(US10919911, Example 17)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@H](CO)COc12
Show InChI InChI=1S/C24H22FN7O3/c1-13-7-18(25)17(8-21(13)31-9-20(26-12-31)14-5-6-14)24(34)27-19-4-2-3-16-22(19)35-11-15(10-33)32-23(16)28-29-30-32/h2-4,7-9,12,14-15,33H,5-6,10-11H2,1H3,(H,27,34)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.9n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483450
PNG
(US10919911, Example 72)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3CC3(CCC3)Oc12
Show InChI InChI=1S/C26H24FN7O2/c1-15-10-19(27)18(11-22(15)33-12-21(28-14-33)16-6-7-16)25(35)29-20-5-2-4-17-23(20)36-26(8-3-9-26)13-34-24(17)30-31-32-34/h2,4-5,10-12,14,16H,3,6-9,13H2,1H3,(H,29,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.6n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483396
PNG
(US10919911, Example 18)
Show SMILES OC[C@@H]1COc2c(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12
Show InChI InChI=1S/C22H20N8O3/c31-10-15-11-33-20-16(21-26-27-28-30(15)21)2-1-3-17(20)25-22(32)18-8-14(6-7-23-18)29-9-19(24-12-29)13-4-5-13/h1-3,6-9,12-13,15,31H,4-5,10-11H2,(H,25,32)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.6n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483386
PNG
(US10919911, Example 8)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3[C@@H](COc12)C1CC1
Show InChI InChI=1S/C27H25FN6O2/c1-15-9-20(28)19(10-23(15)33-11-22(29-13-33)16-5-6-16)27(35)31-21-4-2-3-18-25(21)36-12-24(17-7-8-17)34-14-30-32-26(18)34/h2-4,9-11,13-14,16-17,24H,5-8,12H2,1H3,(H,31,35)/t24-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.7n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483424
PNG
(US10919911, Example 46)
Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)cccc2-c2cncn12
Show InChI InChI=1S/C26H24FN5O2/c1-15-8-20(27)19(9-23(15)31-11-22(29-14-31)17-6-7-17)26(33)30-21-5-3-4-18-24-10-28-13-32(24)16(2)12-34-25(18)21/h3-5,8-11,13-14,16-17H,6-7,12H2,1-2H3,(H,30,33)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.1n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483422
PNG
(US10919911, Example 44)
Show SMILES O=C(Nc1cccc2-c3nncn3CCOc12)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N8O3/c35-26(30-19-3-1-2-18-24(19)37-11-8-33-16-29-31-25(18)33)20-12-22(34-14-21(28-15-34)17-4-5-17)23(13-27-20)32-6-9-36-10-7-32/h1-3,12-17H,4-11H2,(H,30,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.6n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483420
PNG
(US10919911, Example 42)
Show SMILES C[C@H]1Cn2nnnc2-c2cccc(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)c2O1
Show InChI InChI=1S/C24H22FN7O2/c1-13-8-18(25)17(9-21(13)31-11-20(26-12-31)15-6-7-15)24(33)27-19-5-3-4-16-22(19)34-14(2)10-32-23(16)28-29-30-32/h3-5,8-9,11-12,14-15H,6-7,10H2,1-2H3,(H,27,33)/t14-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.8n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483427
PNG
(US10919911, Example 49 | US10919911, Example 52)
Show SMILES C[C@@H]1Cn2cnnc2-c2cccc(NC(=O)c3cc(ccn3)-n3cnc(c3)C3CC3)c2O1
Show InChI InChI=1S/C23H21N7O2/c1-14-10-30-13-26-28-22(30)17-3-2-4-18(21(17)32-14)27-23(31)19-9-16(7-8-24-19)29-11-20(25-12-29)15-5-6-15/h2-4,7-9,11-15H,5-6,10H2,1H3,(H,27,31)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 24.7n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483434
PNG
(US10919911, Example 56)
Show SMILES O=C(Nc1cccc2-c3nncn3CCOc12)c1cc(ccn1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C22H19N7O2/c30-22(18-10-15(6-7-23-18)29-11-19(24-12-29)14-4-5-14)26-17-3-1-2-16-20(17)31-9-8-28-13-25-27-21(16)28/h1-3,6-7,10-14H,4-5,8-9H2,(H,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35.2n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483452
PNG
(US10919911, Example 74)
Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3c(Br)ncn3CCOc12
Show InChI InChI=1S/C25H21BrFN5O2/c1-14-9-18(27)17(10-21(14)32-11-20(28-12-32)15-5-6-15)25(33)30-19-4-2-3-16-22-24(26)29-13-31(22)7-8-34-23(16)19/h2-4,9-13,15H,5-8H2,1H3,(H,30,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM483429
PNG
(US10919911, Example 51)
Show SMILES Cc1ncn2CCOc3c(NC(=O)c4cc(c(C)cc4F)-n4cnc(c4)C4CC4)cccc3-c12
Show InChI InChI=1S/C26H24FN5O2/c1-15-10-20(27)19(11-23(15)32-12-22(29-14-32)17-6-7-17)26(33)30-21-5-3-4-18-24-16(2)28-13-31(24)8-9-34-25(18)21/h3-5,10-14,17H,6-9H2,1-2H3,(H,30,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 307n/an/an/an/an/an/a



TERNS, INC.

US Patent


Assay Description
Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...


US Patent US10919911 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%