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Patent code US10927105

Compile Data Set for Download or QSAR

Found 323 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483868
PNG
(1-(7-(2,5- dichlorobenzyl)-2,7- diazaspiro[4.4]- n...)
Show SMILES CNC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3cc(Cl)ccc3Cl)C2)C1
Show InChI InChI=1S/C20H23Cl2N5O2/c1-23-18(28)17-4-7-27(24-17)19(29)26-9-6-20(13-26)5-8-25(12-20)11-14-10-15(21)2-3-16(14)22/h2-4,7,10H,5-6,8-9,11-13H2,1H3,(H,23,28)
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n/an/a<100n/an/an/an/an/an/a



LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483641
PNG
(US10927105, Ex 3)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2ccc(cc2N2CCOCC2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H24F3N5O4/c22-21(23,24)16-2-1-15(18(13-16)27-9-11-33-12-10-27)14-26-5-7-28(8-6-26)20(32)29-4-3-17(25-29)19(30)31/h1-4,13H,5-12,14H2,(H,30,31)
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n/an/a<100n/an/an/an/an/an/a



LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Fatty acid 2-hydroxylase


(Human)
BDBM483644
PNG
(US10927105, Ex 17)
Show SMILES NC(=O)c1ccn(n1)C(=O)N1CC2CN(Cc3ccc(cc3C(F)(F)F)N3CCOCC3)CC2C1
Show InChI InChI=1S/C23H27F3N6O3/c24-23(25,26)19-9-18(30-5-7-35-8-6-30)2-1-15(19)10-29-11-16-13-31(14-17(16)12-29)22(34)32-4-3-20(28-32)21(27)33/h1-4,9,16-17H,5-8,10-14H2,(H2,27,33)
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n/an/a<100n/an/an/an/an/an/a



LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483654
PNG
(US10927105, Ex 35)
Show SMILES NC(=O)c1ccn(n1)C(=O)N1CC2CN(Cc3ccc(cc3C(F)(F)F)C3(CCOCC3)C(O)=O)CC2C1
Show InChI InChI=1S/C25H28F3N5O5/c26-25(27,28)19-9-18(24(22(35)36)4-7-38-8-5-24)2-1-15(19)10-31-11-16-13-32(14-17(16)12-31)23(37)33-6-3-20(30-33)21(29)34/h1-3,6,9,16-17H,4-5,7-8,10-14H2,(H2,29,34)(H,35,36)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483656
PNG
(US10927105, Ex 37)
Show SMILES CC(C)(O)COc1cccc(CN2CCN(CC2)C(=O)n2ccc(n2)C(N)=O)c1Cl
Show InChI InChI=1S/C20H26ClN5O4/c1-20(2,29)13-30-16-5-3-4-14(17(16)21)12-24-8-10-25(11-9-24)19(28)26-7-6-15(23-26)18(22)27/h3-7,29H,8-13H2,1-2H3,(H2,22,27)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483661
PNG
(1-(4-(3-(4- fluorophenoxy)- benzyl)piperazine-1- c...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2cccc(Oc3ccc(F)cc3)c2)CC1
Show InChI InChI=1S/C22H21FN4O4/c23-17-4-6-18(7-5-17)31-19-3-1-2-16(14-19)15-25-10-12-26(13-11-25)22(30)27-9-8-20(24-27)21(28)29/h1-9,14H,10-13,15H2,(H,28,29)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Fatty acid 2-hydroxylase


(Human)
BDBM483677
PNG
(1-(2-(5-chloro-2- (trifluoromethyl)- benzyl)-2,8- ...)
Show SMILES NC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3cc(Cl)ccc3C(F)(F)F)C2)CC1
Show InChI InChI=1S/C21H23ClF3N5O2/c22-15-1-2-16(21(23,24)25)14(11-15)12-28-8-4-20(13-28)5-9-29(10-6-20)19(32)30-7-3-17(27-30)18(26)31/h1-3,7,11H,4-6,8-10,12-13H2,(H2,26,31)
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n/an/a<100n/an/an/an/an/an/a



LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483688
PNG
(4-chloro-1-(2-(5- chloro-2- (trifluoromethyl)- ben...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CCC2(CCN(Cc3cc(Cl)ccc3C(F)(F)F)C2)CC1
Show InChI InChI=1S/C21H21Cl2F3N4O3/c22-14-1-2-15(21(24,25)26)13(9-14)10-28-6-3-20(12-28)4-7-29(8-5-20)19(33)30-11-16(23)17(27-30)18(31)32/h1-2,9,11H,3-8,10,12H2,(H,31,32)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483705
PNG
(1-(cis-5-([1,1'- biphenyl]-3- yloxy)- octahydrocyc...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C24H23N3O4/c28-23(29)22-9-10-27(25-22)24(30)26-14-18-12-21(13-19(18)15-26)31-20-8-4-7-17(11-20)16-5-2-1-3-6-16/h1-11,18-19,21H,12-15H2,(H,28,29)/t18-,19+,21-
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483715
PNG
(1-(2-(2-chloro-4- morpholinobenzyl)- 2,8-diazaspir...)
Show SMILES NC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3ccc(cc3Cl)N3CCOCC3)C2)CC1
Show InChI InChI=1S/C24H31ClN6O3/c25-20-15-19(29-11-13-34-14-12-29)2-1-18(20)16-28-8-4-24(17-28)5-9-30(10-6-24)23(33)31-7-3-21(27-31)22(26)32/h1-3,7,15H,4-6,8-14,16-17H2,(H2,26,32)
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n/an/a<100n/an/an/an/an/an/a



LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483721
PNG
(1-(cis-5-(methyl(4- (trifluoromethyl)- benzyl)amin...)
Show SMILES CN(Cc1ccc(cc1)C(F)(F)F)[C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)n1ccc(n1)C(N)=O
Show InChI InChI=1S/C21H24F3N5O2/c1-27(10-13-2-4-16(5-3-13)21(22,23)24)17-8-14-11-28(12-15(14)9-17)20(31)29-7-6-18(26-29)19(25)30/h2-7,14-15,17H,8-12H2,1H3,(H2,25,30)/t14-,15+,17-
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483723
PNG
(1-(5-(3- (trifluoromethyl)- benzyl)- octahydropyrr...)
Show SMILES NC(=O)c1ccn(n1)C(=O)N1CC2CN(Cc3cccc(c3)C(F)(F)F)CC2C1
Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)15-3-1-2-12(6-15)7-25-8-13-10-26(11-14(13)9-25)18(29)27-5-4-16(24-27)17(23)28/h1-6,13-14H,7-11H2,(H2,23,28)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483759
PNG
(1-(trans-5-(3- methyl-4- (trifluoromethyl)- phenox...)
Show SMILES Cc1cc(O[C@@H]2C[C@H]3CN(C[C@H]3C2)C(=O)n2ccc(n2)C(O)=O)ccc1C(F)(F)F
Show InChI InChI=1S/C20H20F3N3O4/c1-11-6-14(2-3-16(11)20(21,22)23)30-15-7-12-9-25(10-13(12)8-15)19(29)26-5-4-17(24-26)18(27)28/h2-6,12-13,15H,7-10H2,1H3,(H,27,28)/t12-,13+,15+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483764
PNG
(1-((2S,4R)-2- methyl-4-(methyl(3- (trifluoromethyl...)
Show SMILES C[C@H]1C[C@@H](CCN1C(=O)n1ccc(n1)C(N)=O)N(C)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H24F3N5O2/c1-13-10-16(26(2)12-14-4-3-5-15(11-14)20(21,22)23)6-8-27(13)19(30)28-9-7-17(25-28)18(24)29/h3-5,7,9,11,13,16H,6,8,10,12H2,1-2H3,(H2,24,29)/t13-,16+/m0/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483765
PNG
(1-((2R,4S)-2- methyl-4-(methyl(3- (trifluoromethyl...)
Show SMILES C[C@@H]1C[C@H](CCN1C(=O)n1ccc(n1)C(N)=O)N(C)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H24F3N5O2/c1-13-10-16(26(2)12-14-4-3-5-15(11-14)20(21,22)23)6-8-27(13)19(30)28-9-7-17(25-28)18(24)29/h3-5,7,9,11,13,16H,6,8,10,12H2,1-2H3,(H2,24,29)/t13-,16+/m1/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483775
PNG
(1-(4-(4-chloro-3- (thiazol-2- yl)benzyl)- piperazi...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2ccc(Cl)c(c2)-c2nccs2)CC1
Show InChI InChI=1S/C19H18ClN5O3S/c20-15-2-1-13(11-14(15)17-21-4-10-29-17)12-23-6-8-24(9-7-23)19(28)25-5-3-16(22-25)18(26)27/h1-5,10-11H,6-9,12H2,(H,26,27)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483790
PNG
(4-chloro-1-(trans-5- ((3-chloro-5- fluorobenzyl)ox...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)OCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H18Cl2FN3O4/c20-13-1-10(2-14(22)5-13)9-29-15-3-11-6-24(7-12(11)4-15)19(28)25-8-16(21)17(23-25)18(26)27/h1-2,5,8,11-12,15H,3-4,6-7,9H2,(H,26,27)/t11-,12+,15+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483820
PNG
(1-(trans-5-((4- chloro-3-(thiazol-2- yl)benzyl)oxy...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)OCc1ccc(Cl)c(c1)-c1nccs1
Show InChI InChI=1S/C22H21ClN4O4S/c23-18-2-1-13(7-17(18)20-24-4-6-32-20)12-31-16-8-14-10-26(11-15(14)9-16)22(30)27-5-3-19(25-27)21(28)29/h1-7,14-16H,8-12H2,(H,28,29)/t14-,15+,16+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483826
PNG
(1-(4-(3-((4- (trifluoromethyl)- pyridin-3- yl)oxy)...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2cccc(Oc3cnccc3C(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H20F3N5O4/c23-22(24,25)17-4-6-26-13-19(17)34-16-3-1-2-15(12-16)14-28-8-10-29(11-9-28)21(33)30-7-5-18(27-30)20(31)32/h1-7,12-13H,8-11,14H2,(H,31,32)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483836
PNG
(4-chloro-1-(4-(4- (pyrrolidin-1-yl)-2- (trifluorom...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CCN(Cc2ccc(cc2C(F)(F)F)N2CCCC2)CC1
Show InChI InChI=1S/C21H23ClF3N5O3/c22-17-13-30(26-18(17)19(31)32)20(33)29-9-7-27(8-10-29)12-14-3-4-15(28-5-1-2-6-28)11-16(14)21(23,24)25/h3-4,11,13H,1-2,5-10,12H2,(H,31,32)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483846
PNG
(1-(4-methyl-4- (methyl(2- (pyrrolidin-1-yl)-5- (tr...)
Show SMILES CN(Cc1cc(ccc1N1CCCC1)C(F)(F)F)C1(C)CCN(CC1)C(=O)n1ccc(n1)C(O)=O
Show InChI InChI=1S/C24H30F3N5O3/c1-23(8-13-31(14-9-23)22(35)32-12-7-19(28-32)21(33)34)29(2)16-17-15-18(24(25,26)27)5-6-20(17)30-10-3-4-11-30/h5-7,12,15H,3-4,8-11,13-14,16H2,1-2H3,(H,33,34)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483874
PNG
(N-methyl-1-(cis-5- (methyl(2- (trifluoromethyl)- b...)
Show SMILES CNC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)N(C)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H26F3N5O2/c1-26-20(31)19-7-8-30(27-19)21(32)29-12-15-9-17(10-16(15)13-29)28(2)11-14-5-3-4-6-18(14)22(23,24)25/h3-8,15-17H,9-13H2,1-2H3,(H,26,31)/t15-,16+,17-
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483882
PNG
((S)-1-(4-(3-(4- chlorophenoxy)- benzyl)-2- methylp...)
Show SMILES C[C@H]1CN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CCN1C(=O)n1cc(C)c(n1)C(O)=O
Show InChI InChI=1S/C24H25ClN4O4/c1-16-13-29(26-22(16)23(30)31)24(32)28-11-10-27(14-17(28)2)15-18-4-3-5-21(12-18)33-20-8-6-19(25)7-9-20/h3-9,12-13,17H,10-11,14-15H2,1-2H3,(H,30,31)/t17-/m0/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483808
PNG
((R)-1-(2-methyl-4- (2-(pyrrolidin-1-yl)- 4-(triflu...)
Show SMILES C[C@@H]1CN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CCN1C(=O)n1ccc(n1)C(N)=O
Show InChI InChI=1S/C22H27F3N6O2/c1-15-13-28(10-11-30(15)21(33)31-9-6-18(27-31)20(26)32)14-16-4-5-17(22(23,24)25)12-19(16)29-7-2-3-8-29/h4-6,9,12,15H,2-3,7-8,10-11,13-14H2,1H3,(H2,26,32)/t15-/m1/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483809
PNG
((R)-1-(2-methyl-4- (2-(pyrrolidin-1-yl)- 4-(triflu...)
Show SMILES C[C@@H]1CN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CCN1C(=O)n1ccc(n1)C(O)=O
Show InChI InChI=1S/C22H26F3N5O3/c1-15-13-27(10-11-29(15)21(33)30-9-6-18(26-30)20(31)32)14-16-4-5-17(22(23,24)25)12-19(16)28-7-2-3-8-28/h4-6,9,12,15H,2-3,7-8,10-11,13-14H2,1H3,(H,31,32)/t15-/m1/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483817
PNG
(1-(2-(2-chloro-3- (trifluoromethyl)- benzyl)-2,8- ...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3cccc(c3Cl)C(F)(F)F)C2)CC1
Show InChI InChI=1S/C21H22ClF3N4O3/c22-17-14(2-1-3-15(17)21(23,24)25)12-27-9-5-20(13-27)6-10-28(11-7-20)19(32)29-8-4-16(26-29)18(30)31/h1-4,8H,5-7,9-13H2,(H,30,31)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483821
PNG
(1-(4-(3-(4- chlorophenoxy)-5- fluorobenzyl)- piper...)
Show SMILES Cc1cn(nc1C(O)=O)C(=O)N1CCN(Cc2cc(F)cc(Oc3ccc(Cl)cc3)c2)CC1
Show InChI InChI=1S/C23H22ClFN4O4/c1-15-13-29(26-21(15)22(30)31)23(32)28-8-6-27(7-9-28)14-16-10-18(25)12-20(11-16)33-19-4-2-17(24)3-5-19/h2-5,10-13H,6-9,14H2,1H3,(H,30,31)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483832
PNG
(1-(4-(2-((2R,5R)- 2,5- dimethylpyrrolidin- 1-yl)-4...)
Show SMILES C[C@@H]1CC[C@@H](C)N1c1cc(ccc1CN1CCN(CC1)C(=O)n1ccc(n1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C23H28F3N5O3/c1-15-3-4-16(2)31(15)20-13-18(23(24,25)26)6-5-17(20)14-28-9-11-29(12-10-28)22(34)30-8-7-19(27-30)21(32)33/h5-8,13,15-16H,3-4,9-12,14H2,1-2H3,(H,32,33)/t15-,16-/m1/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483833
PNG
(1-(4-(2-((2S,5S)-2,5- dimethylpyrrolidin- 1-yl)-4-...)
Show SMILES C[C@H]1CC[C@H](C)N1c1cc(ccc1CN1CCN(CC1)C(=O)n1ccc(n1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C23H28F3N5O3/c1-15-3-4-16(2)31(15)20-13-18(23(24,25)26)6-5-17(20)14-28-9-11-29(12-10-28)22(34)30-8-7-19(27-30)21(32)33/h5-8,13,15-16H,3-4,9-12,14H2,1-2H3,(H,32,33)/t15-,16-/m0/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483857
PNG
(4-chloro-1-(4-(3- ((4-(trifluoromethyl)- pyridin-2...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CCN(Cc2cccc(Oc3cc(ccn3)C(F)(F)F)c2)CC1
Show InChI InChI=1S/C22H19ClF3N5O4/c23-17-13-31(28-19(17)20(32)33)21(34)30-8-6-29(7-9-30)12-14-2-1-3-16(10-14)35-18-11-15(4-5-27-18)22(24,25)26/h1-5,10-11,13H,6-9,12H2,(H,32,33)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483872
PNG
(N-methyl-1-(5-(3- (trifluoromethyl)- benzyl)- octa...)
Show SMILES CNC(=O)c1ccn(n1)C(=O)N1CC2CN(Cc3cccc(c3)C(F)(F)F)CC2C1
Show InChI InChI=1S/C20H22F3N5O2/c1-24-18(29)17-5-6-28(25-17)19(30)27-11-14-9-26(10-15(14)12-27)8-13-3-2-4-16(7-13)20(21,22)23/h2-7,14-15H,8-12H2,1H3,(H,24,29)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483876
PNG
(1-(7-(4-morpholino- 2-(trifluoromethyl)- benzyl)-2...)
Show SMILES NC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3ccc(cc3C(F)(F)F)N3CCOCC3)C2)C1
Show InChI InChI=1S/C24H29F3N6O3/c25-24(26,27)19-13-18(31-9-11-36-12-10-31)2-1-17(19)14-30-7-4-23(15-30)5-8-32(16-23)22(35)33-6-3-20(29-33)21(28)34/h1-3,6,13H,4-5,7-12,14-16H2,(H2,28,34)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483883
PNG
(4-chloro-1-(4-(2- (pyrrolidin-1-yl)-4- (trifluorom...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CCN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H23ClF3N5O3/c22-16-13-30(26-18(16)19(31)32)20(33)29-9-7-27(8-10-29)12-14-3-4-15(21(23,24)25)11-17(14)28-5-1-2-6-28/h3-4,11,13H,1-2,5-10,12H2,(H,31,32)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483649
PNG
(US10927105, Ex 26)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CCC2(CCN(Cc3cccc(Cl)c3C(F)(F)F)C2)CC1
Show InChI InChI=1S/C21H21Cl2F3N4O3/c22-14-3-1-2-13(16(14)21(24,25)26)10-28-7-4-20(12-28)5-8-29(9-6-20)19(33)30-11-15(23)17(27-30)18(31)32/h1-3,11H,4-10,12H2,(H,31,32)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483662
PNG
(1-(trans-5-((3- chloro-5- fluorobenzyl)oxy)- octah...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)OCc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H19ClFN3O4/c20-14-3-11(4-15(21)7-14)10-28-16-5-12-8-23(9-13(12)6-16)19(27)24-2-1-17(22-24)18(25)26/h1-4,7,12-13,16H,5-6,8-10H2,(H,25,26)/t12-,13+,16+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483674
PNG
((S)-1-(4-(2-(3- fluoropyrrolidin-1- yl)-4-(trifluo...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2ccc(cc2N2CC[C@H](F)C2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H23F4N5O3/c22-16-3-5-29(13-16)18-11-15(21(23,24)25)2-1-14(18)12-27-7-9-28(10-8-27)20(33)30-6-4-17(26-30)19(31)32/h1-2,4,6,11,16H,3,5,7-10,12-13H2,(H,31,32)/t16-/m0/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483692
PNG
(4-chloro-1-(2-(4- (pyrrolidin-1-yl)-2- (trifluorom...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CCC2(CCN(Cc3ccc(cc3C(F)(F)F)N3CCCC3)C2)CC1
Show InChI InChI=1S/C25H29ClF3N5O3/c26-20-15-34(30-21(20)22(35)36)23(37)33-11-6-24(7-12-33)5-10-31(16-24)14-17-3-4-18(32-8-1-2-9-32)13-19(17)25(27,28)29/h3-4,13,15H,1-2,5-12,14,16H2,(H,35,36)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483694
PNG
(4-chloro-1-(5-(4- (pyrrolidin-1-yl)-2- (trifluorom...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CC2CN(Cc3ccc(cc3C(F)(F)F)N3CCCC3)CC2C1
Show InChI InChI=1S/C23H25ClF3N5O3/c24-19-13-32(28-20(19)21(33)34)22(35)31-11-15-9-29(10-16(15)12-31)8-14-3-4-17(30-5-1-2-6-30)7-18(14)23(25,26)27/h3-4,7,13,15-16H,1-2,5-6,8-12H2,(H,33,34)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483702
PNG
(1-(trans-5-((2- methyl-3- (trifluoromethyl)- benzy...)
Show SMILES Cc1c(CO[C@@H]2C[C@H]3CN(C[C@H]3C2)C(=O)n2ccc(n2)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C21H22F3N3O4/c1-12-13(3-2-4-17(12)21(22,23)24)11-31-16-7-14-9-26(10-15(14)8-16)20(30)27-6-5-18(25-27)19(28)29/h2-6,14-16H,7-11H2,1H3,(H,28,29)/t14-,15+,16+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483707
PNG
(1-(2-((3- (trifluoromethyl)- [1,1'-biphenyl]-4- yl...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3ccc(cc3C(F)(F)F)-c3ccccc3)C2)CC1
Show InChI InChI=1S/C27H27F3N4O3/c28-27(29,30)22-16-20(19-4-2-1-3-5-19)6-7-21(22)17-32-13-9-26(18-32)10-14-33(15-11-26)25(37)34-12-8-23(31-34)24(35)36/h1-8,12,16H,9-11,13-15,17-18H2,(H,35,36)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Fatty acid 2-hydroxylase


(Human)
BDBM483713
PNG
(1-(2-(4-(pyrrolidin- 1-yl)-2- (trifluoromethyl)- b...)
Show SMILES NC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3ccc(cc3C(F)(F)F)N3CCCC3)C2)CC1
Show InChI InChI=1S/C25H31F3N6O2/c26-25(27,28)20-15-19(32-9-1-2-10-32)4-3-18(20)16-31-12-6-24(17-31)7-13-33(14-8-24)23(36)34-11-5-21(30-34)22(29)35/h3-5,11,15H,1-2,6-10,12-14,16-17H2,(H2,29,35)
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n/an/a<100n/an/an/an/an/an/a



LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Fatty acid 2-hydroxylase


(Human)
BDBM483720
PNG
(1-(cis-5-(methyl(2- (trifluoromethyl)- benzyl)amin...)
Show SMILES CN(Cc1ccccc1C(F)(F)F)[C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)n1ccc(n1)C(N)=O
Show InChI InChI=1S/C21H24F3N5O2/c1-27(10-13-4-2-3-5-17(13)21(22,23)24)16-8-14-11-28(12-15(14)9-16)20(31)29-7-6-18(26-29)19(25)30/h2-7,14-16H,8-12H2,1H3,(H2,25,30)/t14-,15+,16-
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483737
PNG
(1-(trans-5-(3,5- dichlorophenoxy)- octahydrocyclop...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)Oc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H17Cl2N3O4/c19-12-5-13(20)7-15(6-12)27-14-3-10-8-22(9-11(10)4-14)18(26)23-2-1-16(21-23)17(24)25/h1-2,5-7,10-11,14H,3-4,8-9H2,(H,24,25)/t10-,11+,14+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483758
PNG
((R)-1-(4-((3-fluoro- [1,1'-biphenyl]-4- yl)methyl)...)
Show SMILES C[C@@H]1CN(Cc2ccc(cc2F)-c2ccccc2)CCN1C(=O)n1ccc(n1)C(O)=O
Show InChI InChI=1S/C23H23FN4O3/c1-16-14-26(11-12-27(16)23(31)28-10-9-21(25-28)22(29)30)15-19-8-7-18(13-20(19)24)17-5-3-2-4-6-17/h2-10,13,16H,11-12,14-15H2,1H3,(H,29,30)/t16-/m1/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483771
PNG
(1-(trans-5-(2- (tetrahydro-2H- pyran-4- yl)phenoxy...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)Oc1ccccc1C1CCOCC1
Show InChI InChI=1S/C23H27N3O5/c27-22(28)20-5-8-26(24-20)23(29)25-13-16-11-18(12-17(16)14-25)31-21-4-2-1-3-19(21)15-6-9-30-10-7-15/h1-5,8,15-18H,6-7,9-14H2,(H,27,28)/t16-,17+,18+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483778
PNG
(1-(trans-5-([1,1'- biphenyl]-3- ylmethoxy)- octahy...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)OCc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C25H25N3O4/c29-24(30)23-9-10-28(26-23)25(31)27-14-20-12-22(13-21(20)15-27)32-16-17-5-4-8-19(11-17)18-6-2-1-3-7-18/h1-11,20-22H,12-16H2,(H,29,30)/t20-,21+,22+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483794
PNG
(1-(trans-5-([1,1'- biphenyl]-3- yloxy)- octahydroc...)
Show SMILES OC(=O)c1nn(cc1Cl)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C24H22ClN3O4/c25-21-14-28(26-22(21)23(29)30)24(31)27-12-17-10-20(11-18(17)13-27)32-19-8-4-7-16(9-19)15-5-2-1-3-6-15/h1-9,14,17-18,20H,10-13H2,(H,29,30)/t17-,18+,20+
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483799
PNG
((S)-1-(4-(3-(4- chlorophenoxy)- benzyl)-2- methylp...)
Show SMILES C[C@H]1CN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CCN1C(=O)n1ccc(n1)C(O)=O
Show InChI InChI=1S/C23H23ClN4O4/c1-16-14-26(11-12-27(16)23(31)28-10-9-21(25-28)22(29)30)15-17-3-2-4-20(13-17)32-19-7-5-18(24)6-8-19/h2-10,13,16H,11-12,14-15H2,1H3,(H,29,30)/t16-/m0/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483804
PNG
(1-(4-(3-(2- chlorophenoxy)-5- fluorobenzyl)- piper...)
Show SMILES OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2cc(F)cc(Oc3ccccc3Cl)c2)CC1
Show InChI InChI=1S/C22H20ClFN4O4/c23-18-3-1-2-4-20(18)32-17-12-15(11-16(24)13-17)14-26-7-9-27(10-8-26)22(31)28-6-5-19(25-28)21(29)30/h1-6,11-13H,7-10,14H2,(H,29,30)
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM483810
PNG
((S)-1-(2-methyl-4- (4-(pyrrolidin-1-yl)- 2-(triflu...)
Show SMILES C[C@H]1CN(Cc2ccc(cc2C(F)(F)F)N2CCCC2)CCN1C(=O)n1ccc(n1)C(O)=O
Show InChI InChI=1S/C22H26F3N5O3/c1-15-13-27(10-11-29(15)21(33)30-9-6-19(26-30)20(31)32)14-16-4-5-17(28-7-2-3-8-28)12-18(16)22(23,24)25/h4-6,9,12,15H,2-3,7-8,10-11,13-14H2,1H3,(H,31,32)/t15-/m0/s1
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LUNDBECK LA JOLLA RESEARCH CENTER, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...


US Patent US10927105 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%