BindingDB logo
myBDB logout

Patent code US10927111

Compile Data Set for Download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRAF/CRAF


(Homo sapiens (Human))
BDBM483999
PNG
(N-(3-(2-(ethyIamino)-7- methylpyrido[2,3-d]pyrimid...)
Show SMILES CCNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F3N6O/c1-4-28-23-30-12-16-9-19(14(3)31-21(16)33-23)18-11-17(6-5-13(18)2)32-22(34)15-7-8-29-20(10-15)24(25,26)27/h5-12H,4H2,1-3H3,(H,32,34)(H,28,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484008
PNG
(N-(6-methyl-5-(7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-19(18-8-15-10-29-22(27-3)32-20(15)30-13(18)2)9-17(11-28-12)31-21(33)14-5-4-6-16(7-14)23(24,25)26/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483970
PNG
(N-[4-methyl-3-[7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-4-5-16(31-21(33)14-6-7-28-19(9-14)23(24,25)26)10-17(12)18-8-15-11-29-22(27-3)32-20(15)30-13(18)2/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483979
PNG
(7,7-difluoro-N-(2-fluoro-4-methyl-5- (7-methyl-2-(...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCC3(CCC(F)(F)C3)C2)c(F)cc1C
Show InChI InChI=1S/C25H27F3N6O/c1-14-8-19(26)20(32-23(35)34-7-6-24(13-34)4-5-25(27,28)12-24)10-17(14)18-9-16-11-30-22(29-3)33-21(16)31-15(18)2/h8-11H,4-7,12-13H2,1-3H3,(H,32,35)(H,29,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483986
PNG
((R)-2-(tert-butyl)-N-(2-fluoro-4-methyl-5-(7-methy...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@H](C2)C(C)(C)C)c(F)cc1C
Show InChI InChI=1S/C25H31FN6O2/c1-14-9-19(26)20(30-24(33)32-7-8-34-21(13-32)25(3,4)5)11-17(14)18-10-16-12-28-23(27-6)31-22(16)29-15(18)2/h9-12,21H,7-8,13H2,1-6H3,(H,30,33)(H,27,28,29,31)/t21-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483997
PNG
(3-chloro-N-(4-methyl-3-(7-methyl-2- (methylamino)p...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2Cl)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H18ClF3N6O/c1-11-4-5-14(32-21(34)15-6-7-29-19(18(15)24)23(25,26)27)9-16(11)17-8-13-10-30-22(28-3)33-20(13)31-12(17)2/h4-10H,1-3H3,(H,32,34)(H,28,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484001
PNG
(N-(3-(2-(cyclopropylamino)-7- methylpyrido[2,3-d]p...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc2cnc(NC3CC3)nc2nc1C
Show InChI InChI=1S/C25H21F3N6O/c1-13-3-4-18(32-23(35)15-7-8-29-21(10-15)25(26,27)28)11-19(13)20-9-16-12-30-24(33-17-5-6-17)34-22(16)31-14(20)2/h3-4,7-12,17H,5-6H2,1-2H3,(H,32,35)(H,30,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484011
PNG
(2-methyl-N-(6-methyl-5-(2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)c2cccc(c2C)C(F)(F)F)cnc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-17(5-4-6-19(12)23(24,25)26)21(33)31-16-8-18(13(2)28-11-16)14-7-15-10-30-22(27-3)32-20(15)29-9-14/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484015
PNG
((3R)-N-[2-fluoro-4-methyl-5-[7- methyl-2-(methylam...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)OCC(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O2/c1-12-6-18(24)19(31-22(34)33-5-4-15(10-33)35-11-23(25,26)27)8-16(12)17-7-14-9-29-21(28-3)32-20(14)30-13(17)2/h6-9,15H,4-5,10-11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484017
PNG
(N-[4-methyl-3-[2- (methylamino)pyrido[2,3-d]pyrimi...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H17F3N6O/c1-12-3-4-16(30-20(32)13-5-6-27-18(8-13)22(23,24)25)9-17(12)14-7-15-11-29-21(26-2)31-19(15)28-10-14/h3-11H,1-2H3,(H,30,32)(H,26,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484029
PNG
(N-[3-[7-ethenyl-2- (methylamino)pyrido[2,3-d]pyrim...)
Show SMILES CNc1ncc2cc(c(C=C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H19F3N6O/c1-4-19-18(9-15-12-30-23(28-3)33-21(15)32-19)17-11-16(6-5-13(17)2)31-22(34)14-7-8-29-20(10-14)24(25,26)27/h4-12H,1H2,2-3H3,(H,31,34)(H,28,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484032
PNG
(N-[3-[7-methoxy-2- (methylamino)pyrido[2,3-d]pyrim...)
Show SMILES CNc1ncc2cc(c(OC)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O2/c1-12-4-5-15(30-20(33)13-6-7-28-18(9-13)23(24,25)26)10-16(12)17-8-14-11-29-22(27-2)32-19(14)31-21(17)34-3/h4-11H,1-3H3,(H,30,33)(H,27,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484031
PNG
(N-[3-[7-ethynyl-2- (methylamino)pyrido[2,3-d]pyrim...)
Show SMILES CNc1ncc2cc(c(nc2n1)C#N)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H16F3N7O/c1-12-3-4-15(31-21(34)13-5-6-29-19(8-13)23(24,25)26)9-16(12)17-7-14-11-30-22(28-2)33-20(14)32-18(17)10-27/h3-9,11H,1-2H3,(H,31,34)(H,28,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484037
PNG
(N-[4-methyl-3-[2-(methylamino)-7- (trifluoromethyl...)
Show SMILES CNc1ncc2cc(-c3cc(NC(=O)c4ccnc(c4)C(F)(F)F)ccc3C)c(nc2n1)C(F)(F)F
Show InChI InChI=1S/C23H16F6N6O/c1-11-3-4-14(33-20(36)12-5-6-31-17(8-12)22(24,25)26)9-15(11)16-7-13-10-32-21(30-2)35-19(13)34-18(16)23(27,28)29/h3-10H,1-2H3,(H,33,36)(H,30,32,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483970
PNG
(N-[4-methyl-3-[7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-4-5-16(31-21(33)14-6-7-28-19(9-14)23(24,25)26)10-17(12)18-8-15-11-29-22(27-3)32-20(15)30-13(18)2/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484042
PNG
((3R)-N-[3-[7-cyano-2- (methylamino)pyrido[2,3-d]py...)
Show SMILES CNc1ncc2cc(c(nc2n1)C#N)-c1cc(NC(=O)N2CC[C@H](C2)OC(F)(F)F)ccc1C
Show InChI InChI=1S/C22H20F3N7O2/c1-12-3-4-14(29-21(33)32-6-5-15(11-32)34-22(23,24)25)8-16(12)17-7-13-10-28-20(27-2)31-19(13)30-18(17)9-26/h3-4,7-8,10,15H,5-6,11H2,1-2H3,(H,29,33)(H,27,28,30,31)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483981
PNG
(Synthesis of (R)—N-(2-fluoro-4-methyl-5-(7-me...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O/c1-12-6-18(24)19(31-22(34)33-5-4-14(11-33)9-23(25,26)27)8-16(12)17-7-15-10-29-21(28-3)32-20(15)30-13(17)2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483987
PNG
((R)-2-(tert-butyl)-N-(2-fluoro-4-methyl-5-(7-methy...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@@H](C2)C(C)(C)C)c(F)cc1C
Show InChI InChI=1S/C25H31FN6O2/c1-14-9-19(26)20(30-24(33)32-7-8-34-21(13-32)25(3,4)5)11-17(14)18-10-16-12-28-23(27-6)31-22(16)29-15(18)2/h9-12,21H,7-8,13H2,1-6H3,(H,30,33)(H,27,28,29,31)/t21-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483991
PNG
(N-(4-methyl-3-(7-methyl-2- (methylamino)pyrido[2)3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2cc(ccn2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-4-5-16(31-21(33)19-9-15(6-7-28-19)23(24,25)26)10-17(12)18-8-14-11-29-22(27-3)32-20(14)30-13(18)2/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483998
PNG
(2-methyl-N-(4-methyl-3-(7-methyl-2- (methylamino)p...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2cc(C)nc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F3N6O/c1-12-5-6-17(32-22(34)15-7-13(2)30-20(9-15)24(25,26)27)10-18(12)19-8-16-11-29-23(28-4)33-21(16)31-14(19)3/h5-11H,1-4H3,(H,32,34)(H,28,29,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484021
PNG
((2S)-N--[4-methyl-3-[2- (methylamino)pyrido[2,3-d]...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CCO[C@@H](C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C21H21F3N6O2/c1-12-3-4-15(28-20(31)30-5-6-32-17(11-30)21(22,23)24)8-16(12)13-7-14-10-27-19(25-2)29-18(14)26-9-13/h3-4,7-10,17H,5-6,11H2,1-2H3,(H,28,31)(H,25,26,27,29)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484026
PNG
((2R)-N-[2-fluoro-4-methyl-5-[2- (methylamino)pyrid...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CCO[C@H](C2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C21H20F4N6O2/c1-11-5-15(22)16(29-20(32)31-3-4-33-17(10-31)21(23,24)25)7-14(11)12-6-13-9-28-19(26-2)30-18(13)27-8-12/h5-9,17H,3-4,10H2,1-2H3,(H,29,32)(H,26,27,28,30)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484000
PNG
(N-(3-(7-ethyl-2- (methylamino)pyrido[2,3-d]pyrimid...)
Show SMILES CCc1nc2nc(NC)ncc2cc1-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F3N6O/c1-4-19-18(9-15-12-30-23(28-3)33-21(15)32-19)17-11-16(6-5-13(17)2)31-22(34)14-7-8-29-20(10-14)24(25,26)27/h5-12H,4H2,1-3H3,(H,31,34)(H,28,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484031
PNG
(N-[3-[7-ethynyl-2- (methylamino)pyrido[2,3-d]pyrim...)
Show SMILES CNc1ncc2cc(c(nc2n1)C#N)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H16F3N7O/c1-12-3-4-15(31-21(34)13-5-6-29-19(8-13)23(24,25)26)9-16(12)17-7-14-11-30-22(28-2)33-20(14)32-18(17)10-27/h3-9,11H,1-2H3,(H,31,34)(H,28,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484034
PNG
(N-[3-[7-(2-hydroxyethoxy)-2- (methylamino)pyrido[2...)
Show SMILES CNc1ncc2cc(c(OCCO)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F3N6O3/c1-13-3-4-16(31-21(35)14-5-6-29-19(10-14)24(25,26)27)11-17(13)18-9-15-12-30-23(28-2)33-20(15)32-22(18)36-8-7-34/h3-6,9-12,34H,7-8H2,1-2H3,(H,31,35)(H,28,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483993
PNG
(N-(4-methyl-3-(7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H20F3N5O/c1-13-7-8-18(31-22(33)15-5-4-6-17(9-15)24(25,26)27)11-19(13)20-10-16-12-29-23(28-3)32-21(16)30-14(20)2/h4-12H,1-3H3,(H,31,33)(H,28,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483981
PNG
(Synthesis of (R)—N-(2-fluoro-4-methyl-5-(7-me...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O/c1-12-6-18(24)19(31-22(34)33-5-4-14(11-33)9-23(25,26)27)8-16(12)17-7-15-10-29-21(28-3)32-20(15)30-13(17)2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483981
PNG
(Synthesis of (R)—N-(2-fluoro-4-methyl-5-(7-me...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O/c1-12-6-18(24)19(31-22(34)33-5-4-14(11-33)9-23(25,26)27)8-16(12)17-7-15-10-29-21(28-3)32-20(15)30-13(17)2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484004
PNG
(N-(3-(2-((2-hydroxyethyl)amino)-7- methylpyrido[2,...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc2cnc(NCCO)nc2nc1C
Show InChI InChI=1S/C24H21F3N6O2/c1-13-3-4-17(32-22(35)15-5-6-28-20(10-15)24(25,26)27)11-18(13)19-9-16-12-30-23(29-7-8-34)33-21(16)31-14(19)2/h3-6,9-12,34H,7-8H2,1-2H3,(H,32,35)(H,29,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484005
PNG
(3-methyl-N-(4-methyl-3-(7-methyl-2- (methylamino)p...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2C)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F3N6O/c1-12-5-6-16(32-22(34)17-7-8-29-20(13(17)2)24(25,26)27)10-18(12)19-9-15-11-30-23(28-4)33-21(15)31-14(19)3/h5-11H,1-4H3,(H,32,34)(H,28,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484006
PNG
(N-(4-methyl-3-(7-methyl-2-((1- methylpiperidin-4- ...)
Show SMILES CN1CCC(CC1)Nc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C28H28F3N7O/c1-16-4-5-21(35-26(39)18-6-9-32-24(13-18)28(29,30)31)14-22(16)23-12-19-15-33-27(37-25(19)34-17(23)2)36-20-7-10-38(3)11-8-20/h4-6,9,12-15,20H,7-8,10-11H2,1-3H3,(H,35,39)(H,33,34,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483970
PNG
(N-[4-methyl-3-[7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-4-5-16(31-21(33)14-6-7-28-19(9-14)23(24,25)26)10-17(12)18-8-15-11-29-22(27-3)32-20(15)30-13(18)2/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484010
PNG
(N-(6-methyl-5-(2- (methylamino)pyrido[2,3-d]pyrimi...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)cnc1C
Show InChI InChI=1S/C21H16F3N7O/c1-11-16(13-5-14-9-29-20(25-2)31-18(14)28-8-13)7-15(10-27-11)30-19(32)12-3-4-26-17(6-12)21(22,23)24/h3-10H,1-2H3,(H,30,32)(H,25,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484012
PNG
(N-(3-(2-amino-7-methylpyrido[2,3- d]pyrimidin-6-yl...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc2cnc(N)nc2nc1C
Show InChI InChI=1S/C22H17F3N6O/c1-11-3-4-15(30-20(32)13-5-6-27-18(8-13)22(23,24)25)9-16(11)17-7-14-10-28-21(26)31-19(14)29-12(17)2/h3-10H,1-2H3,(H,30,32)(H2,26,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484018
PNG
((3R)—N-[4-methyl-3-[2-(methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C21H21F3N6O/c1-12-3-4-16(28-20(31)30-6-5-15(11-30)21(22,23)24)8-17(12)13-7-14-10-27-19(25-2)29-18(14)26-9-13/h3-4,7-10,15H,5-6,11H2,1-2H3,(H,28,31)(H,25,26,27,29)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484021
PNG
((2S)-N--[4-methyl-3-[2- (methylamino)pyrido[2,3-d]...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CCO[C@@H](C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C21H21F3N6O2/c1-12-3-4-15(28-20(31)30-5-6-32-17(11-30)21(22,23)24)8-16(12)13-7-14-10-27-19(25-2)29-18(14)26-9-13/h3-4,7-10,17H,5-6,11H2,1-2H3,(H,28,31)(H,25,26,27,29)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484024
PNG
((3R)-N-[2-fluoro-4-methyl-5-[2- (methylamino)pyrid...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CC[C@H](C2)OC(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C21H20F4N6O2/c1-11-5-16(22)17(29-20(32)31-4-3-14(10-31)33-21(23,24)25)7-15(11)12-6-13-9-28-19(26-2)30-18(13)27-8-12/h5-9,14H,3-4,10H2,1-2H3,(H,29,32)(H,26,27,28,30)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483966
PNG
((R)-N-(2-fluoro-4-methyl-5-(7-methyl- 2-(methylami...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C22H22F4N6O/c1-11-6-17(23)18(30-21(33)32-5-4-14(10-32)22(24,25)26)8-15(11)16-7-13-9-28-20(27-3)31-19(13)29-12(16)2/h6-9,14H,4-5,10H2,1-3H3,(H,30,33)(H,27,28,29,31)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483974
PNG
((2R)-N-[2-fluoro-4-methyl-5-[7- methyl-2-(methylam...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@H](C2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C22H22F4N6O2/c1-11-6-16(23)17(30-21(33)32-4-5-34-18(10-32)22(24,25)26)8-14(11)15-7-13-9-28-20(27-3)31-19(13)29-12(15)2/h6-9,18H,4-5,10H2,1-3H3,(H,30,33)(H,27,28,29,31)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483976
PNG
((2R)-N-[4-methyl-3-[7-methyl-2- (methylamino)pyrid...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@H](C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H23F3N6O2/c1-12-4-5-15(29-21(32)31-6-7-33-18(11-31)22(23,24)25)9-16(12)17-8-14-10-27-20(26-3)30-19(14)28-13(17)2/h4-5,8-10,18H,6-7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483978
PNG
(N-(4-methyl-3-(7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCC(C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H23F3N6O/c1-12-4-5-16(29-21(32)31-7-6-15(11-31)22(23,24)25)9-17(12)18-8-14-10-27-20(26-3)30-19(14)28-13(18)2/h4-5,8-10,15H,6-7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483992
PNG
((S)-3-(difluoromethoxy)-N-(2-fluoro- 4-methyl-5-(2...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)OC(F)F)c(F)cc1C
Show InChI InChI=1S/C22H23F3N6O2/c1-11-6-17(23)18(29-22(32)31-5-4-14(10-31)33-20(24)25)8-15(11)16-7-13-9-27-21(26-3)30-19(13)28-12(16)2/h6-9,14,20H,4-5,10H2,1-3H3,(H,29,32)(H,26,27,28,30)/t14-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484027
PNG
((3S)-N/-[6-methyl-5-[2- (methylamino)pyrido[2,3-d]...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)OC(F)(F)F)cnc1C
Show InChI InChI=1S/C20H20F3N7O2/c1-11-16(12-5-13-8-27-18(24-2)29-17(13)26-7-12)6-14(9-25-11)28-19(31)30-4-3-15(10-30)32-20(21,22)23/h5-9,15H,3-4,10H2,1-2H3,(H,28,31)(H,24,26,27,29)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483972
PNG
(US10927111, Example 8 | US10927111, Example 9)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)OC(F)(F)F)ccc1C
Show InChI InChI=1S/C22H23F3N6O2/c1-12-4-5-15(29-21(32)31-7-6-16(11-31)33-22(23,24)25)9-17(12)18-8-14-10-27-20(26-3)30-19(14)28-13(18)2/h4-5,8-10,16H,6-7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)/t16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483972
PNG
(US10927111, Example 8 | US10927111, Example 9)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)OC(F)(F)F)ccc1C
Show InChI InChI=1S/C22H23F3N6O2/c1-12-4-5-15(29-21(32)31-7-6-16(11-31)33-22(23,24)25)9-17(12)18-8-14-10-27-20(26-3)30-19(14)28-13(18)2/h4-5,8-10,16H,6-7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)/t16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483989
PNG
((S)—N-(2-fluoro-4-methyl-5-(7-methyl-2-(methy...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O2/c1-12-6-18(24)19(31-22(34)33-4-5-35-15(11-33)9-23(25,26)27)8-16(12)17-7-14-10-29-21(28-3)32-20(14)30-13(17)2/h6-8,10,15H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483996
PNG
(N-(4-methyl-3-(7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2cncc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-4-5-17(31-21(33)15-6-16(11-28-9-15)23(24,25)26)8-18(12)19-7-14-10-29-22(27-3)32-20(14)30-13(19)2/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484002
PNG
(N-(4-methyl-3-(7-methyl-2-((2- morpholinoethyl)ami...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc2cnc(NCCN3CCOCC3)nc2nc1C
Show InChI InChI=1S/C28H28F3N7O2/c1-17-3-4-21(36-26(39)19-5-6-32-24(14-19)28(29,30)31)15-22(17)23-13-20-16-34-27(37-25(20)35-18(23)2)33-7-8-38-9-11-40-12-10-38/h3-6,13-16H,7-12H2,1-2H3,(H,36,39)(H,33,34,35,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484014
PNG
(N-(4-methyl-3-(7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2cnnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H18F3N7O/c1-11-4-5-15(30-20(33)14-7-18(22(23,24)25)32-28-10-14)8-16(11)17-6-13-9-27-21(26-3)31-19(13)29-12(17)2/h4-10H,1-3H3,(H,30,33)(H,26,27,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483970
PNG
(N-[4-methyl-3-[7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-4-5-16(31-21(33)14-6-7-28-19(9-14)23(24,25)26)10-17(12)18-8-15-11-29-22(27-3)32-20(15)30-13(18)2/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484023
PNG
((3S)-N-[2-f]uoro-4-methyl-5-[2- (methylamino)pyrid...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)OC(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C21H20F4N6O2/c1-11-5-16(22)17(29-20(32)31-4-3-14(10-31)33-21(23,24)25)7-15(11)12-6-13-9-28-19(26-2)30-18(13)27-8-12/h5-9,14H,3-4,10H2,1-2H3,(H,29,32)(H,26,27,28,30)/t14-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484025
PNG
((2S)-N-[2-fluoro-4-methyl-5-[2- (methylamino)pyrid...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CCO[C@@H](C2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C21H20F4N6O2/c1-11-5-15(22)16(29-20(32)31-3-4-33-17(10-31)21(23,24)25)7-14(11)12-6-13-9-28-19(26-2)30-18(13)27-8-12/h5-9,17H,3-4,10H2,1-2H3,(H,29,32)(H,26,27,28,30)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484041
PNG
((3S)-N-[7-cyano-2- (methylamino)pyrido[2,3-d]pyrim...)
Show SMILES CNc1ncc2cc(c(nc2n1)C#N)-c1cc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)ccc1C
Show InChI InChI=1S/C23H22F3N7O/c1-13-3-4-16(30-22(34)33-6-5-14(12-33)9-23(24,25)26)8-17(13)18-7-15-11-29-21(28-2)32-20(15)31-19(18)10-27/h3-4,7-8,11,14H,5-6,9,12H2,1-2H3,(H,30,34)(H,28,29,31,32)/t14-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484043
PNG
((3R)-N-[3-[7-cyano-2- (methylamino)pyrido[2,3-d]py...)
Show SMILES CNc1ncc2cc(c(nc2n1)C#N)-c1cc(NC(=O)N2CC[C@@H](C2)OC(F)(F)F)ccc1C
Show InChI InChI=1S/C22H20F3N7O2/c1-12-3-4-14(29-21(33)32-6-5-15(11-32)34-22(23,24)25)8-16(12)17-7-13-10-28-20(27-2)31-19(13)30-18(17)9-26/h3-4,7-8,10,15H,5-6,11H2,1-2H3,(H,29,33)(H,27,28,30,31)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483967
PNG
(N-(2-fluoro-4-methyl-5-(7-methyl-2- (methylamino)p...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC=C(C2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C22H20F4N6O/c1-11-6-17(23)18(30-21(33)32-5-4-14(10-32)22(24,25)26)8-15(11)16-7-13-9-28-20(27-3)31-19(13)29-12(16)2/h4,6-9H,5,10H2,1-3H3,(H,30,33)(H,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483971
PNG
(N-[2-fluoro-4-methyl-5-[7-methyl-2- (methylamino)p...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C23H18F4N6O/c1-11-6-17(24)18(32-21(34)13-4-5-29-19(8-13)23(25,26)27)9-15(11)16-7-14-10-30-22(28-3)33-20(14)31-12(16)2/h4-10H,1-3H3,(H,32,34)(H,28,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483977
PNG
((2S)-N-methyl-3-[7-methyl-2- (methylamino)pyrido[2...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@@H](C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H23F3N6O2/c1-12-4-5-15(29-21(32)31-6-7-33-18(11-31)22(23,24)25)9-16(12)17-8-14-10-27-20(26-3)30-19(14)28-13(17)2/h4-5,8-10,18H,6-7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483981
PNG
(Synthesis of (R)—N-(2-fluoro-4-methyl-5-(7-me...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O/c1-12-6-18(24)19(31-22(34)33-5-4-14(11-33)9-23(25,26)27)8-16(12)17-7-15-10-29-21(28-3)32-20(15)30-13(17)2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483981
PNG
(Synthesis of (R)—N-(2-fluoro-4-methyl-5-(7-me...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O/c1-12-6-18(24)19(31-22(34)33-5-4-14(11-33)9-23(25,26)27)8-16(12)17-7-15-10-29-21(28-3)32-20(15)30-13(17)2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483988
PNG
(N-(4-methyl-3-(7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCn3cnc(c3C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H23F3N8O/c1-13-4-5-16(9-17(13)18-8-15-10-29-22(28-3)33-21(15)31-14(18)2)32-23(36)34-6-7-35-12-30-20(19(35)11-34)24(25,26)27/h4-5,8-10,12H,6-7,11H2,1-3H3,(H,32,36)(H,28,29,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484000
PNG
(N-(3-(7-ethyl-2- (methylamino)pyrido[2,3-d]pyrimid...)
Show SMILES CCc1nc2nc(NC)ncc2cc1-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F3N6O/c1-4-19-18(9-15-12-30-23(28-3)33-21(15)32-19)17-11-16(6-5-13(17)2)31-22(34)14-7-8-29-20(10-14)24(25,26)27/h5-12H,4H2,1-3H3,(H,31,34)(H,28,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484003
PNG
(N-(4-methyl-3-(7-methyl-2-((2- (pyrrolidin-1- yl)e...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc2cnc(NCCN3CCCC3)nc2nc1C
Show InChI InChI=1S/C28H28F3N7O/c1-17-5-6-21(36-26(39)19-7-8-32-24(14-19)28(29,30)31)15-22(17)23-13-20-16-34-27(37-25(20)35-18(23)2)33-9-12-38-10-3-4-11-38/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,36,39)(H,33,34,35,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484018
PNG
((3R)—N-[4-methyl-3-[2-(methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C21H21F3N6O/c1-12-3-4-16(28-20(31)30-6-5-15(11-30)21(22,23)24)8-17(12)13-7-14-10-27-19(25-2)29-18(14)26-9-13/h3-4,7-10,15H,5-6,11H2,1-2H3,(H,28,31)(H,25,26,27,29)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483965
PNG
((S)-N-(2-fluoro-4-methyl-5-(7-methyl- 2-(methylami...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C22H22F4N6O/c1-11-6-17(23)18(30-21(33)32-5-4-14(10-32)22(24,25)26)8-15(11)16-7-13-9-28-20(27-3)31-19(13)29-12(16)2/h6-9,14H,4-5,10H2,1-3H3,(H,30,33)(H,27,28,29,31)/t14-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483975
PNG
((2S)-N-[2-fluoro-4-methyl-5-[7- methyl-2-(methylam...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@@H](C2)C(F)(F)F)c(F)cc1C
Show InChI InChI=1S/C22H22F4N6O2/c1-11-6-16(23)17(30-21(33)32-4-5-34-18(10-32)22(24,25)26)8-14(11)15-7-13-9-28-20(27-3)31-19(13)29-12(15)2/h6-9,18H,4-5,10H2,1-3H3,(H,30,33)(H,27,28,29,31)/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483985
PNG
(3-(tert-butyl)-N-(2-fluoro-4-methyl-5- (7-methyl-2...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCC(C2)C(C)(C)C)c(F)cc1C
Show InChI InChI=1S/C25H31FN6O/c1-14-9-20(26)21(30-24(33)32-8-7-17(13-32)25(3,4)5)11-18(14)19-10-16-12-28-23(27-6)31-22(16)29-15(19)2/h9-12,17H,7-8,13H2,1-6H3,(H,30,33)(H,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483989
PNG
((S)—N-(2-fluoro-4-methyl-5-(7-methyl-2-(methy...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCO[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O2/c1-12-6-18(24)19(31-22(34)33-4-5-35-15(11-33)9-23(25,26)27)8-16(12)17-7-14-10-29-21(28-3)32-20(14)30-13(17)2/h6-8,10,15H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484009
PNG
(N-(6-methyl-5-(2- (methylamino)pyrido[2,3-d]pyrimi...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C
Show InChI InChI=1S/C22H17F3N6O/c1-12-18(14-6-15-10-29-21(26-2)31-19(15)28-9-14)8-17(11-27-12)30-20(32)13-4-3-5-16(7-13)22(23,24)25/h3-11H,1-2H3,(H,30,32)(H,26,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484013
PNG
(N-(3-(2-(cyclopropanecarboxamido)- 7-methylpyrido[...)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc2cnc(NC(=O)C3CC3)nc2nc1C
Show InChI InChI=1S/C26H21F3N6O2/c1-13-3-6-18(33-24(37)16-7-8-30-21(10-16)26(27,28)29)11-19(13)20-9-17-12-31-25(34-22(17)32-14(20)2)35-23(36)15-4-5-15/h3,6-12,15H,4-5H2,1-2H3,(H,33,37)(H,31,32,34,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484020
PNG
(3S-N-[4-methyl-3-[2- (methylamino)pyrido[2,3-d]pyr...)
Show SMILES CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)N2CC[C@@H](C2)OC(F)(F)F)ccc1C
Show InChI InChI=1S/C21H21F3N6O2/c1-12-3-4-15(28-20(31)30-6-5-16(11-30)32-21(22,23)24)8-17(12)13-7-14-10-27-19(25-2)29-18(14)26-9-13/h3-4,7-10,16H,5-6,11H2,1-2H3,(H,28,31)(H,25,26,27,29)/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484028
PNG
(N-[3-[7-chloro-2- (methylamino)pyrido[2,3-d]pyrimi...)
Show SMILES CNc1ncc2cc(c(Cl)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H16ClF3N6O/c1-11-3-4-14(30-20(33)12-5-6-28-17(8-12)22(24,25)26)9-15(11)16-7-13-10-29-21(27-2)32-19(13)31-18(16)23/h3-10H,1-2H3,(H,30,33)(H,27,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484032
PNG
(N-[3-[7-methoxy-2- (methylamino)pyrido[2,3-d]pyrim...)
Show SMILES CNc1ncc2cc(c(OC)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O2/c1-12-4-5-15(30-20(33)13-6-7-28-18(9-13)23(24,25)26)10-16(12)17-8-14-11-29-22(27-2)32-19(14)31-21(17)34-3/h4-11H,1-3H3,(H,30,33)(H,27,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484033
PNG
(N-[3-[7-ethoxy-2- (methylamino)pyrido[2,3-d]pyrimi...)
Show SMILES CCOc1nc2nc(NC)ncc2cc1-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F3N6O2/c1-4-35-22-18(9-15-12-30-23(28-3)33-20(15)32-22)17-11-16(6-5-13(17)2)31-21(34)14-7-8-29-19(10-14)24(25,26)27/h5-12H,4H2,1-3H3,(H,31,34)(H,28,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM484040
PNG
(4-([4-methyl-3-[7-methyl-2- rmethylamino)pyrido[2,...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2cc[n+]([O-])c(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O2/c1-12-4-5-16(30-21(33)14-6-7-32(34)19(9-14)23(24,25)26)10-17(12)18-8-15-11-28-22(27-3)31-20(15)29-13(18)2/h4-11H,1-3H3,(H,30,33)(H,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483970
PNG
(N-[4-methyl-3-[7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F3N6O/c1-12-4-5-16(31-21(33)14-6-7-28-19(9-14)23(24,25)26)10-17(12)18-8-15-11-29-22(27-3)32-20(15)30-13(18)2/h4-11H,1-3H3,(H,31,33)(H,27,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483980
PNG
(N-(4-methyl-3-(7-methyl-2- (methylamino)pyrido[2,3...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC=C(C2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H21F3N6O/c1-12-4-5-16(29-21(32)31-7-6-15(11-31)22(23,24)25)9-17(12)18-8-14-10-27-20(26-3)30-19(14)28-13(18)2/h4-6,8-10H,7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483981
PNG
(Synthesis of (R)—N-(2-fluoro-4-methyl-5-(7-me...)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](CC(F)(F)F)C2)c(F)cc1C
Show InChI InChI=1S/C23H24F4N6O/c1-12-6-18(24)19(31-22(34)33-5-4-14(11-33)9-23(25,26)27)8-16(12)17-7-15-10-29-21(28-3)32-20(15)30-13(17)2/h6-8,10,14H,4-5,9,11H2,1-3H3,(H,31,34)(H,28,29,30,32)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483968
PNG
(US10927111, Example 4 | US10927111, Example 5)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)SC(F)(F)F)ccc1C
Show InChI InChI=1S/C22H23F3N6OS/c1-12-4-5-15(29-21(32)31-7-6-16(11-31)33-22(23,24)25)9-17(12)18-8-14-10-27-20(26-3)30-19(14)28-13(18)2/h4-5,8-10,16H,6-7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)/t16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM483968
PNG
(US10927111, Example 4 | US10927111, Example 5)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)SC(F)(F)F)ccc1C
Show InChI InChI=1S/C22H23F3N6OS/c1-12-4-5-15(29-21(32)31-7-6-16(11-31)33-22(23,24)25)9-17(12)18-8-14-10-27-20(26-3)30-19(14)28-13(18)2/h4-5,8-10,16H,6-7,11H2,1-3H3,(H,29,32)(H,26,27,28,30)/t16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.550n/an/an/an/an/an/a



KINNATE BIOPHARMA INC.

US Patent


Assay Description
Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...


US Patent US10927111 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%