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Patent code US10933063

Compile Data Set for Download or QSAR

Found 258 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484231
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C26H23FN4O3/c1-3-23(32)30-14-5-6-19(30)26-29-25(20-16-28-13-15-31(20)26)17-9-11-18(12-10-17)34-22-8-4-7-21(33-2)24(22)27/h3-4,7-13,15-16,19H,1,5-6,14H2,2H3/t19-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480004
PNG
((R)-1-(3-(1-(4-(2-fluoro-3-methoxyphenoxy)phenyl)i...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN(C3)C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-3-24(33)31-14-5-6-19(17-31)27-30-26(21-16-29-13-15-32(21)27)18-9-11-20(12-10-18)35-23-8-4-7-22(34-2)25(23)28/h3-4,7-13,15-16,19H,1,5-6,14,17H2,2H3/t19-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484228
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n3ccnc(C)c23)c1F
Show InChI InChI=1S/C28H27FN4O3/c1-4-24(34)32-16-6-5-8-21(32)28-31-26(27-18(2)30-15-17-33(27)28)19-11-13-20(14-12-19)36-23-10-7-9-22(35-3)25(23)29/h4,7,9-15,17,21H,1,5-6,8,16H2,2-3H3/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484217
PNG
((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1
Show InChI InChI=1S/C26H24N4O3/c1-3-24(31)29-14-5-8-22(29)26-28-25(23-17-27-13-15-30(23)26)18-9-11-19(12-10-18)33-21-7-4-6-20(16-21)32-2/h3-4,6-7,9-13,15-17,22H,1,5,8,14H2,2H3/t22-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484221
PNG
((S)-1-(2-(1-(4-(2,3- difluorophenoxy)phenyl)imidaz...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C25H20F2N4O2/c1-2-22(32)30-13-4-6-19(30)25-29-24(20-15-28-12-14-31(20)25)16-8-10-17(11-9-16)33-21-7-3-5-18(26)23(21)27/h2-3,5,7-12,14-15,19H,1,4,6,13H2/t19-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484306
PNG
((R,E)-4-(cyclopropyl(methyl)amino)- 1-(3-(1-(4-(2-...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)\C=C\CN(C)C3CC3)n3ccnc(C)c23)c1F
Show InChI InChI=1S/C32H34FN5O3/c1-21-31-30(22-9-13-25(14-10-22)41-27-7-4-6-26(40-3)29(27)33)35-32(38(31)19-16-34-21)23-15-18-37(20-23)28(39)8-5-17-36(2)24-11-12-24/h4-10,13-14,16,19,23-24H,11-12,15,17-18,20H2,1-3H3/b8-5+/t23-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484395
PNG
((R)-4-(3-(1-acryloylpyrrolidin- 3-yl)-5-ethoxyimid...)
Show SMILES CCOc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C=C)n12)-c1ccc(cc1)C(=O)Nc1ccccn1
Show InChI InChI=1S/C27H26N6O3/c1-3-23(34)32-14-12-20(17-32)26-31-25(21-15-28-16-24(33(21)26)36-4-2)18-8-10-19(11-9-18)27(35)30-22-7-5-6-13-29-22/h3,5-11,13,15-16,20H,1,4,12,14,17H2,2H3,(H,29,30,35)/t20-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484398
PNG
((R)-4-(3-(1-acryloylpyrrolidin- 3-yl)-5-ethoxyimid...)
Show SMILES COCc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C=C)n12)-c1ccc(cc1F)C(=O)Nc1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C28H24F4N6O3/c1-3-24(39)37-9-7-17(14-37)26-36-25(22-13-33-12-19(15-41-2)38(22)26)20-5-4-16(10-21(20)29)27(40)35-23-11-18(6-8-34-23)28(30,31)32/h3-6,8,10-13,17H,1,7,9,14-15H2,2H3,(H,34,35,40)/t17-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484371
PNG
((S)-4-(3-(1-acryloylpiperidin- 2-yl)-8-methylimida...)
Show SMILES Cc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCCN1C(=O)C=C
Show InChI InChI=1S/C27H26N6O2/c1-3-23(34)32-16-7-5-8-21(32)26-31-24(25-18(2)28-15-17-33(25)26)19-10-12-20(13-11-19)27(35)30-22-9-4-6-14-29-22/h3-4,6,9-15,17,21H,1,5,7-8,16H2,2H3,(H,29,30,35)/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484262
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(C)c23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-4-23(33)31-15-6-7-20(31)27-30-25(26-17(2)29-14-16-32(26)27)18-10-12-19(13-11-18)35-22-9-5-8-21(34-3)24(22)28/h4-5,8-14,16,20H,1,6-7,15H2,2-3H3/t20-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484290
PNG
((R)-1-(3-(5-(2- (dimethylamino)ethoxy)-1-(4-(2- fl...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C=C)n3c(OCCN(C)C)cncc23)c1F
Show InChI InChI=1S/C30H32FN5O4/c1-5-26(37)35-14-13-21(19-35)30-33-29(23-17-32-18-27(36(23)30)39-16-15-34(2)3)20-9-11-22(12-10-20)40-25-8-6-7-24(38-4)28(25)31/h5-12,17-18,21H,1,13-16,19H2,2-4H3/t21-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484293
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C#CC)n3ccnc(C)c23)c1F
Show InChI InChI=1S/C28H25FN4O3/c1-4-6-24(34)32-15-13-20(17-32)28-31-26(27-18(2)30-14-16-33(27)28)19-9-11-21(12-10-19)36-23-8-5-7-22(35-3)25(23)29/h5,7-12,14,16,20H,13,15,17H2,1-3H3/t20-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484295
PNG
((R)-1-(3-(5-ethoxy-1-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES CCOc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C=C)n12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C28H27FN4O4/c1-4-24(34)32-14-13-19(17-32)28-31-27(21-15-30-16-25(33(21)28)36-5-2)18-9-11-20(12-10-18)37-23-8-6-7-22(35-3)26(23)29/h4,6-12,15-16,19H,1,5,13-14,17H2,2-3H3/t19-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM480004
PNG
((R)-1-(3-(1-(4-(2-fluoro-3-methoxyphenoxy)phenyl)i...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN(C3)C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-3-24(33)31-14-5-6-19(17-31)27-30-26(21-16-29-13-15-32(21)27)18-9-11-20(12-10-18)35-23-8-4-7-22(34-2)25(23)28/h3-4,7-13,15-16,19H,1,5-6,14,17H2,2H3/t19-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484223
PNG
((S)-1-(2-(1-(4-(3-chloro-2- fluorophenoxy)phenyl)i...)
Show SMILES Fc1c(Cl)cccc1Oc1ccc(cc1)-c1nc([C@@H]2CCCN2C(=O)C=C)n2ccncc12
Show InChI InChI=1S/C25H20ClFN4O2/c1-2-22(32)30-13-4-6-19(30)25-29-24(20-15-28-12-14-31(20)25)16-8-10-17(11-9-16)33-21-7-3-5-18(26)23(21)27/h2-3,5,7-12,14-15,19H,1,4,6,13H2/t19-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484229
PNG
((S)-1-(2-(1-(4-(3- chlorophenoxy)phenyl)imidazo[1,...)
Show SMILES Clc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1
Show InChI InChI=1S/C25H21ClN4O2/c1-2-23(31)29-13-4-7-21(29)25-28-24(22-16-27-12-14-30(22)25)17-8-10-19(11-9-17)32-20-6-3-5-18(26)15-20/h2-3,5-6,8-12,14-16,21H,1,4,7,13H2/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484275
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C=C)n3c(C)cnc(C)c23)c1F
Show InChI InChI=1S/C28H27FN4O3/c1-5-24(34)32-14-13-20(16-32)28-31-26(27-18(3)30-15-17(2)33(27)28)19-9-11-21(12-10-19)36-23-8-6-7-22(35-4)25(23)29/h5-12,15,20H,1,13-14,16H2,2-4H3/t20-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484407
PNG
((R)-4-(3-(1-acryloylpyrrolidin- 3-yl)-5-ethoxy-8- ...)
Show SMILES CCOc1cnc(C)c2c(nc([C@@H]3CCN(C3)C(=O)C=C)n12)-c1ccc(cc1)C(=O)Nc1ccccn1
Show InChI InChI=1S/C28H28N6O3/c1-4-23(35)33-15-13-21(17-33)27-32-25(26-18(3)30-16-24(34(26)27)37-5-2)19-9-11-20(12-10-19)28(36)31-22-8-6-7-14-29-22/h4,6-12,14,16,21H,1,5,13,15,17H2,2-3H3,(H,29,31,36)/t21-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484217
PNG
((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)imidazo[1...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1
Show InChI InChI=1S/C26H24N4O3/c1-3-24(31)29-14-5-8-22(29)26-28-25(23-17-27-13-15-30(23)26)18-9-11-19(12-10-18)33-21-7-4-6-20(16-21)32-2/h3-4,6-7,9-13,15-17,22H,1,5,8,14H2,2H3/t22-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484263
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3c(C)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-4-24(33)31-14-6-7-20(31)27-30-26(21-16-29-15-17(2)32(21)27)18-10-12-19(13-11-18)35-23-9-5-8-22(34-3)25(23)28/h4-5,8-13,15-16,20H,1,6-7,14H2,2-3H3/t20-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484249
PNG
((S)-1-(2-(1-(4-(3- methoxyphenoxy)phenyl)-8- methy...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n3ccnc(C)c23)c1
Show InChI InChI=1S/C28H28N4O3/c1-4-25(33)31-16-6-5-10-24(31)28-30-26(27-19(2)29-15-17-32(27)28)20-11-13-21(14-12-20)35-23-9-7-8-22(18-23)34-3/h4,7-9,11-15,17-18,24H,1,5-6,10,16H2,2-3H3/t24-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484283
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3c(OC)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O4/c1-4-23(33)31-14-6-7-19(31)27-30-26(20-15-29-16-24(35-3)32(20)27)17-10-12-18(13-11-17)36-22-9-5-8-21(34-2)25(22)28/h4-5,8-13,15-16,19H,1,6-7,14H2,2-3H3/t19-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484296
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES CCCOc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C=C)n12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C29H29FN4O4/c1-4-15-37-26-17-31-16-22-28(32-29(34(22)26)20-13-14-33(18-20)25(35)5-2)19-9-11-21(12-10-19)38-24-8-6-7-23(36-3)27(24)30/h5-12,16-17,20H,2,4,13-15,18H2,1,3H3/t20-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484297
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES CCCOc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C#CC)n12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C30H29FN4O4/c1-4-7-26(36)34-15-14-21(19-34)30-33-29(23-17-32-18-27(35(23)30)38-16-5-2)20-10-12-22(13-11-20)39-25-9-6-8-24(37-3)28(25)31/h6,8-13,17-18,21H,5,14-16,19H2,1-3H3/t21-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484256
PNG
((S)-1-(2-(1-(4-(3- fluorophenoxy)phenyl)-8- methyl...)
Show SMILES Cc1nccn2c(nc(-c3ccc(Oc4cccc(F)c4)cc3)c12)[C@@H]1CCCCN1C(=O)C=C
Show InChI InChI=1S/C27H25FN4O2/c1-3-24(33)31-15-5-4-9-23(31)27-30-25(26-18(2)29-14-16-32(26)27)19-10-12-21(13-11-19)34-22-8-6-7-20(28)17-22/h3,6-8,10-14,16-17,23H,1,4-5,9,15H2,2H3/t23-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484307
PNG
((R)-1-(3-(8-ethyl-1-(4-(2-fluoro-3- methoxyphenoxy...)
Show SMILES CCc1nccn2c(nc(-c3ccc(Oc4cccc(OC)c4F)cc3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C28H27FN4O3/c1-4-21-27-26(18-9-11-20(12-10-18)36-23-8-6-7-22(35-3)25(23)29)31-28(33(27)16-14-30-21)19-13-15-32(17-19)24(34)5-2/h5-12,14,16,19H,2,4,13,15,17H2,1,3H3/t19-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484385
PNG
((R)-4-(3-(1-acryloylpiperidin- 3-yl)-5,8-dimethyli...)
Show SMILES Cc1cnc(C)c2c(nc([C@@H]3CCCN(C3)C(=O)C=C)n12)-c1ccc(cc1)C(=O)Nc1ccccn1
Show InChI InChI=1S/C28H28N6O2/c1-4-24(35)33-15-7-8-22(17-33)27-32-25(26-19(3)30-16-18(2)34(26)27)20-10-12-21(13-11-20)28(36)31-23-9-5-6-14-29-23/h4-6,9-14,16,22H,1,7-8,15,17H2,2-3H3,(H,29,31,36)/t22-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484221
PNG
((S)-1-(2-(1-(4-(2,3- difluorophenoxy)phenyl)imidaz...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C25H20F2N4O2/c1-2-22(32)30-13-4-6-19(30)25-29-24(20-15-28-12-14-31(20)25)16-8-10-17(11-9-16)33-21-7-3-5-18(26)23(21)27/h2-3,5,7-12,14-15,19H,1,4,6,13H2/t19-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484228
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n3ccnc(C)c23)c1F
Show InChI InChI=1S/C28H27FN4O3/c1-4-24(34)32-16-6-5-8-21(32)28-31-26(27-18(2)30-15-17-33(27)28)19-11-13-20(14-12-19)36-23-10-7-9-22(35-3)25(23)29/h4,7,9-15,17,21H,1,5-6,8,16H2,2-3H3/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484231
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C26H23FN4O3/c1-3-23(32)30-14-5-6-19(30)26-29-25(20-16-28-13-15-31(20)26)17-9-11-18(12-10-17)34-22-8-4-7-21(33-2)24(22)27/h3-4,7-13,15-16,19H,1,5-6,14H2,2H3/t19-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484263
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3c(C)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-4-24(33)31-14-6-7-20(31)27-30-26(21-16-29-15-17(2)32(21)27)18-10-12-19(13-11-18)35-23-9-5-8-22(34-3)25(23)28/h4-5,8-13,15-16,20H,1,6-7,14H2,2-3H3/t20-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484287
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C#CC)n3c(OC)cncc23)c1F
Show InChI InChI=1S/C28H25FN4O4/c1-4-6-24(34)32-14-13-19(17-32)28-31-27(21-15-30-16-25(36-3)33(21)28)18-9-11-20(12-10-18)37-23-8-5-7-22(35-2)26(23)29/h5,7-12,15-16,19H,13-14,17H2,1-3H3/t19-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484301
PNG
((R)-1-(3-(5-cyclobutoxy-1-(4-(2- fluoro-3- methoxy...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C=C)n3c(OC4CCC4)cncc23)c1F
Show InChI InChI=1S/C30H29FN4O4/c1-3-26(36)34-15-14-20(18-34)30-33-29(23-16-32-17-27(35(23)30)39-21-6-4-7-21)19-10-12-22(13-11-19)38-25-9-5-8-24(37-2)28(25)31/h3,5,8-13,16-17,20-21H,1,4,6-7,14-15,18H2,2H3/t20-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484405
PNG
((S)-4-(3-(1-acryloylpyrrolidin- 2-yl)-5-ethoxyimid...)
Show SMILES COCc1cncc2c(nc([C@@H]3CCCN3C(=O)C=C)n12)-c1ccc(cc1)C(=O)Nc1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N6O3/c1-3-24(38)36-12-4-5-21(36)26-35-25(22-15-32-14-20(16-40-2)37(22)26)17-6-8-18(9-7-17)27(39)34-23-13-19(10-11-33-23)28(29,30)31/h3,6-11,13-15,21H,1,4-5,12,16H2,2H3,(H,33,34,39)/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484203
PNG
((S)-1-(2-(1-(4-(2-Fluoro-3-methoxyphenoxy)phenyl)i...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C27H25FN4O3/c1-3-24(33)31-15-5-4-7-20(31)27-30-26(21-17-29-14-16-32(21)27)18-10-12-19(13-11-18)35-23-9-6-8-22(34-2)25(23)28/h3,6,8-14,16-17,20H,1,4-5,7,15H2,2H3/t20-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484269
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C=C)n3ccncc23)c1F
Show InChI InChI=1S/C26H23FN4O3/c1-3-23(32)30-13-11-18(16-30)26-29-25(20-15-28-12-14-31(20)26)17-7-9-19(10-8-17)34-22-6-4-5-21(33-2)24(22)27/h3-10,12,14-15,18H,1,11,13,16H2,2H3/t18-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484230
PNG
((S)-1-(2-(1-(4-(3-methoxy-2- methylphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1C
Show InChI InChI=1S/C27H26N4O3/c1-4-25(32)30-15-6-7-21(30)27-29-26(22-17-28-14-16-31(22)27)19-10-12-20(13-11-19)34-24-9-5-8-23(33-3)18(24)2/h4-5,8-14,16-17,21H,1,6-7,15H2,2-3H3/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484286
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C=C)n3c(OC)cncc23)c1F
Show InChI InChI=1S/C27H25FN4O4/c1-4-23(33)31-13-12-18(16-31)27-30-26(20-14-29-15-24(35-3)32(20)27)17-8-10-19(11-9-17)36-22-7-5-6-21(34-2)25(22)28/h4-11,14-15,18H,1,12-13,16H2,2-3H3/t18-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484305
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COCCOc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C=C)n12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C29H29FN4O5/c1-4-25(35)33-13-12-20(18-33)29-32-28(22-16-31-17-26(34(22)29)38-15-14-36-2)19-8-10-21(11-9-19)39-24-7-5-6-23(37-3)27(24)30/h4-11,16-17,20H,1,12-15,18H2,2-3H3/t20-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484265
PNG
((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3c(C)cnc(C)c23)c1F
Show InChI InChI=1S/C28H27FN4O3/c1-5-24(34)32-15-7-8-21(32)28-31-26(27-18(3)30-16-17(2)33(27)28)19-11-13-20(14-12-19)36-23-10-6-9-22(35-4)25(23)29/h5-6,9-14,16,21H,1,7-8,15H2,2-4H3/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484298
PNG
((R)-1-(3-(5-butoxy-1-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES CCCCOc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C#CC)n12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C31H31FN4O4/c1-4-6-17-39-28-19-33-18-24-30(34-31(36(24)28)22-15-16-35(20-22)27(37)8-5-2)21-11-13-23(14-12-21)40-26-10-7-9-25(38-3)29(26)32/h7,9-14,18-19,22H,4,6,15-17,20H2,1-3H3/t22-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484375
PNG
((S)-4-(3-(1-acryloylpyrrolidin- 2-yl)-5,8-dimethyl...)
Show SMILES Cc1cnc(C)c2c(nc([C@@H]3CCCN3C(=O)C=C)n12)-c1ccc(cc1)C(=O)Nc1ccccn1
Show InChI InChI=1S/C27H26N6O2/c1-4-23(34)32-15-7-8-21(32)26-31-24(25-18(3)29-16-17(2)33(25)26)19-10-12-20(13-11-19)27(35)30-22-9-5-6-14-28-22/h4-6,9-14,16,21H,1,7-8,15H2,2-3H3,(H,28,30,35)/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484299
PNG
(1-((3R)-3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C=C)n3c(OC4CCOC4)cncc23)c1F
Show InChI InChI=1S/C30H29FN4O5/c1-3-26(36)34-13-11-20(17-34)30-33-29(23-15-32-16-27(35(23)30)40-22-12-14-38-18-22)19-7-9-21(10-8-19)39-25-6-4-5-24(37-2)28(25)31/h3-10,15-16,20,22H,1,11-14,17-18H2,2H3/t20-,22?/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484270
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C#CC)n3ccncc23)c1F
Show InChI InChI=1S/C27H23FN4O3/c1-3-5-24(33)31-14-12-19(17-31)27-30-26(21-16-29-13-15-32(21)27)18-8-10-20(11-9-18)35-23-7-4-6-22(34-2)25(23)28/h4,6-11,13,15-16,19H,12,14,17H2,1-2H3/t19-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484241
PNG
((S)-1-(2-(8-methyl-1-(4-(m- tolyloxy)phenyl)imidaz...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n3ccnc(C)c23)c1
Show InChI InChI=1S/C28H28N4O2/c1-4-25(33)31-16-6-5-10-24(31)28-30-26(27-20(3)29-15-17-32(27)28)21-11-13-22(14-12-21)34-23-9-7-8-19(2)18-23/h4,7-9,11-15,17-18,24H,1,5-6,10,16H2,2-3H3/t24-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484294
PNG
((R)-1-(3-(5-ethoxy-1-(4-(2-fluoro-3- methoxyphenox...)
Show SMILES CCOc1cncc2c(nc([C@@H]3CCN(C3)C(=O)C#CC)n12)-c1ccc(Oc2cccc(OC)c2F)cc1
Show InChI InChI=1S/C29H27FN4O4/c1-4-7-25(35)33-15-14-20(18-33)29-32-28(22-16-31-17-26(34(22)29)37-5-2)19-10-12-21(13-11-19)38-24-9-6-8-23(36-3)27(24)30/h6,8-13,16-17,20H,5,14-15,18H2,1-3H3/t20-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484227
PNG
((S)-1-(2-(1-(3-chloro-4- phenoxyphenyl)imidazo[1,5...)
Show SMILES Clc1cc(ccc1Oc1ccccc1)-c1nc([C@@H]2CCCN2C(=O)C=C)n2ccncc12
Show InChI InChI=1S/C25H21ClN4O2/c1-2-23(31)29-13-6-9-20(29)25-28-24(21-16-27-12-14-30(21)25)17-10-11-22(19(26)15-17)32-18-7-4-3-5-8-18/h2-5,7-8,10-12,14-16,20H,1,6,9,13H2/t20-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484243
PNG
((S)-1-(2-(1-(4-(3-chloro-2- fluorophenoxy)phenyl)-...)
Show SMILES Cc1nccn2c(nc(-c3ccc(Oc4cccc(Cl)c4F)cc3)c12)[C@@H]1CCCCN1C(=O)C=C
Show InChI InChI=1S/C27H24ClFN4O2/c1-3-23(34)32-15-5-4-8-21(32)27-31-25(26-17(2)30-14-16-33(26)27)18-10-12-19(13-11-18)35-22-9-6-7-20(28)24(22)29/h3,6-7,9-14,16,21H,1,4-5,8,15H2,2H3/t21-/m0/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484321
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C#CC)n3ccnc(CF)c23)c1F
Show InChI InChI=1S/C28H24F2N4O3/c1-3-5-24(35)33-14-12-19(17-33)28-32-26(27-21(16-29)31-13-15-34(27)28)18-8-10-20(11-9-18)37-23-7-4-6-22(36-2)25(23)30/h4,6-11,13,15,19H,12,14,16-17H2,1-2H3/t19-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM484276
PNG
((R)-1-(3-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCN(C3)C(=O)C#CC)n3c(C)cnc(C)c23)c1F
Show InChI InChI=1S/C29H27FN4O3/c1-5-7-25(35)33-15-14-21(17-33)29-32-27(28-19(3)31-16-18(2)34(28)29)20-10-12-22(13-11-20)37-24-9-6-8-23(36-4)26(24)30/h6,8-13,16,21H,14-15,17H2,1-4H3/t21-/m1/s1
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Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

US Patent


Assay Description
Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...


US Patent US10933063 (2021)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 258 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%