BindingDB logo
myBDB logout

Patent code US10934288

Compile Data Set for Download or QSAR

Found 241 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414817
PNG
(US10435405, Example 234 | US10934288, Example 234)
Show SMILES Cc1cc(cc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1)C1COCCN1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414588
PNG
(US10435405, Example 6 | US10934288, Example 6)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3cccc(F)c3)n[nH]c2cn1
Show InChI InChI=1S/C20H14F2N4O2/c1-28-17-7-3-6-14(22)18(17)15-9-13-16(10-23-15)25-26-19(13)24-20(27)11-4-2-5-12(21)8-11/h2-10H,1H3,(H2,24,25,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414590
PNG
(US10435405, Example 8 | US10934288, Example 8)
Show SMILES CCc1ccc(cc1)C(=O)Nc1n[nH]c2cnc(cc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C22H19FN4O2/c1-3-13-7-9-14(10-8-13)22(28)25-21-15-11-17(24-12-18(15)26-27-21)20-16(23)5-4-6-19(20)29-2/h4-12H,3H2,1-2H3,(H2,25,26,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414593
PNG
(US10435405, Example 11 | US10934288, Example 11)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3cc(F)cc(F)c3)n[nH]c2cn1
Show InChI InChI=1S/C20H13F3N4O2/c1-29-17-4-2-3-14(23)18(17)15-8-13-16(9-24-15)26-27-19(13)25-20(28)10-5-11(21)7-12(22)6-10/h2-9H,1H3,(H2,25,26,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414595
PNG
(US10435405, Example 13 | US10934288, Example 13)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3ccc4OCOc4c3)n[nH]c2cn1
Show InChI InChI=1S/C21H15FN4O4/c1-28-17-4-2-3-13(22)19(17)14-8-12-15(9-23-14)25-26-20(12)24-21(27)11-5-6-16-18(7-11)30-10-29-16/h2-9H,10H2,1H3,(H2,24,25,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414599
PNG
(US10435405, Example 17 | US10934288, Example 17)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3cccc(c3)N3CCNC(=O)C3)n[nH]c2cn1
Show InChI InChI=1S/C24H21FN6O3/c1-34-20-7-3-6-17(25)22(20)18-11-16-19(12-27-18)29-30-23(16)28-24(33)14-4-2-5-15(10-14)31-9-8-26-21(32)13-31/h2-7,10-12H,8-9,13H2,1H3,(H,26,32)(H2,28,29,30,33)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414606
PNG
(US10435405, Example 24 | US10934288, Example 24)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3ccc(cc3)N3CCOCC3)n[nH]c2cn1
Show InChI InChI=1S/C24H22FN5O3/c1-32-21-4-2-3-18(25)22(21)19-13-17-20(14-26-19)28-29-23(17)27-24(31)15-5-7-16(8-6-15)30-9-11-33-12-10-30/h2-8,13-14H,9-12H2,1H3,(H2,27,28,29,31)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414607
PNG
(US10435405, Example 25 | US10934288, Example 25)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3ccc(cc3)N3CCNC(=O)C3)n[nH]c2cn1
Show InChI InChI=1S/C24H21FN6O3/c1-34-20-4-2-3-17(25)22(20)18-11-16-19(12-27-18)29-30-23(16)28-24(33)14-5-7-15(8-6-14)31-10-9-26-21(32)13-31/h2-8,11-12H,9-10,13H2,1H3,(H,26,32)(H2,28,29,30,33)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414611
PNG
(US10435405, Example 28 | US10934288, Example 28)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cnc(cc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C26H27FN6O2/c1-3-32-11-13-33(14-12-32)18-9-7-17(8-10-18)26(34)29-25-19-15-21(28-16-22(19)30-31-25)24-20(27)5-4-6-23(24)35-2/h4-10,15-16H,3,11-14H2,1-2H3,(H2,29,30,31,34)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414622
PNG
(US10435405, Example 39 | US10934288, Example 39)
Show SMILES COc1cccc(F)c1-c1cc2c(n[nH]c2cn1)N1CCN(CC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H21FN6O/c1-32-22-4-2-3-19(25)23(22)20-13-18-21(15-27-20)28-29-24(18)31-11-9-30(10-12-31)17-7-5-16(14-26)6-8-17/h2-8,13,15H,9-12H2,1H3,(H,28,29)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414628
PNG
(US10435405, Example 45 | US10934288, Example 45)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(cc12)-c1c(C)cccc1C
Show InChI InChI=1S/C25H27N5/c1-17-5-4-6-18(2)24(17)22-15-21-23(16-26-22)27-28-25(21)19-7-9-20(10-8-19)30-13-11-29(3)12-14-30/h4-10,15-16H,11-14H2,1-3H3,(H,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414630
PNG
(US10435405, Example 47 | US10934288, Example 47)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(cc12)-c1c(F)cccc1Cl
Show InChI InChI=1S/C23H21ClFN5/c1-29-9-11-30(12-10-29)16-7-5-15(6-8-16)23-17-13-20(26-14-21(17)27-28-23)22-18(24)3-2-4-19(22)25/h2-8,13-14H,9-12H2,1H3,(H,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414634
PNG
(US10435405, Example 51 | US10934288, Example 51)
Show SMILES CCOc1cccc(F)c1-c1cc2c(n[nH]c2cn1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C25H26FN5O/c1-3-32-23-6-4-5-20(26)24(23)21-15-19-22(16-27-21)28-29-25(19)17-7-9-18(10-8-17)31-13-11-30(2)12-14-31/h4-10,15-16H,3,11-14H2,1-2H3,(H,28,29)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414640
PNG
(US10435405, Example 57 | US10934288, Example 57)
Show SMILES COCCNC(=O)c1cc(F)c(c(F)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18F2N6O2/c1-28-10-12(8-25-28)19-13-7-16(24-9-17(13)26-27-19)18-14(21)5-11(6-15(18)22)20(29)23-3-4-30-2/h5-10H,3-4H2,1-2H3,(H,23,29)(H,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414665
PNG
(US10435405, Example 82 | US10934288, Example 82)
Show SMILES Cc1cc(NC(=O)CN2C3CCC2CC3)cc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26FN7O/c1-14-7-16(29-23(34)13-33-17-3-4-18(33)6-5-17)8-20(26)24(14)21-9-19-22(11-27-21)30-31-25(19)15-10-28-32(2)12-15/h7-12,17-18H,3-6,13H2,1-2H3,(H,29,34)(H,30,31)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414666
PNG
(US10435405, Example 83 | US10934288, Example 83)
Show SMILES Cc1cc(NC(=O)CN2C[C@H]3CC[C@@H]2C3)cc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414668
PNG
(US10435405, Example 85 | US10934288, Example 85)
Show SMILES Cc1cc(NC(=O)CC#N)cc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16FN7O/c1-11-5-13(25-18(29)3-4-22)6-15(21)19(11)16-7-14-17(9-23-16)26-27-20(14)12-8-24-28(2)10-12/h5-10H,3H2,1-2H3,(H,25,29)(H,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414683
PNG
(US10435405, Example 100 | US10934288, Example 100)
Show SMILES CNC(=O)c1ccc(cc1F)-c1n[nH]c2cnc(cc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C21H16F2N4O2/c1-24-21(28)12-7-6-11(8-15(12)23)20-13-9-16(25-10-17(13)26-27-20)19-14(22)4-3-5-18(19)29-2/h3-10H,1-2H3,(H,24,28)(H,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414687
PNG
(US10435405, Example 104 | US10934288, Example 104)
Show SMILES COc1cccc(F)c1-c1cc2c(n[nH]c2cn1)-n1cnc(c1)C(=O)NC(C)C
Show InChI InChI=1S/C20H19FN6O2/c1-11(2)24-20(28)16-9-27(10-23-16)19-12-7-14(22-8-15(12)25-26-19)18-13(21)5-4-6-17(18)29-3/h4-11H,1-3H3,(H,24,28)(H,25,26)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414705
PNG
(US10435405, Example 122 | US10934288, Example 122)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C18H16F2N6/c1-21-6-10-3-13(19)17(14(20)4-10)15-5-12-16(8-22-15)24-25-18(12)11-7-23-26(2)9-11/h3-5,7-9,21H,6H2,1-2H3,(H,24,25)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414714
PNG
(US10435405, Example 131 | US10934288, Example 131)
Show SMILES CNCc1cc(F)c(-c2cc3c(n[nH]c3cn2)-c2cnn(C)c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C19H16F4N6/c1-24-6-10-3-13(19(21,22)23)17(14(20)4-10)15-5-12-16(8-25-15)27-28-18(12)11-7-26-29(2)9-11/h3-5,7-9,24H,6H2,1-2H3,(H,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414721
PNG
(US10435405, Example 138 | US10934288, Example 138)
Show SMILES CNCc1ccc(F)c(-c2cc3c(n[nH]c3cn2)-c2cnn(C)c2)c1OC
Show InChI InChI=1S/C19H19FN6O/c1-21-7-11-4-5-14(20)17(19(11)27-3)15-6-13-16(9-22-15)24-25-18(13)12-8-23-26(2)10-12/h4-6,8-10,21H,7H2,1-3H3,(H,24,25)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414726
PNG
(US10435405, Example 143 | US10934288, Example 143)
Show SMILES COC1CN(Cc2cc(F)c(c(F)c2)-c2cc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3cn2)C1
Show InChI InChI=1S/C29H31F2N7O2/c1-36-7-9-38(10-8-36)20-5-3-19(4-6-20)29(39)33-28-22-13-25(32-14-26(22)34-35-28)27-23(30)11-18(12-24(27)31)15-37-16-21(17-37)40-2/h3-6,11-14,21H,7-10,15-17H2,1-2H3,(H2,33,34,35,39)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414735
PNG
(US10435405, Example 152 | US10934288, Example 152)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cnc(cc12)-c1c(C)cccc1F
Show InChI InChI=1S/C25H25FN6O/c1-16-4-3-5-20(26)23(16)21-14-19-22(15-27-21)29-30-24(19)28-25(33)17-6-8-18(9-7-17)32-12-10-31(2)11-13-32/h3-9,14-15H,10-13H2,1-2H3,(H2,28,29,30,33)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414740
PNG
(US10435405, Example 157 | US10934288, Example 157)
Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3cnc(cc23)-c2c(C)cccc2F)c(N)c1
Show InChI InChI=1S/C25H26FN7O/c1-15-4-3-5-19(26)23(15)21-13-18-22(14-28-21)30-31-24(18)29-25(34)17-7-6-16(12-20(17)27)33-10-8-32(2)9-11-33/h3-7,12-14H,8-11,27H2,1-2H3,(H2,29,30,31,34)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414771
PNG
(2-(3-Fluoro-5-methyl-4-(3- (1-methyl-1H-pyrazol-4-...)
Show SMILES Cc1cc(CNCC#N)cc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18FN7/c1-12-5-13(8-23-4-3-22)6-16(21)19(12)17-7-15-18(10-24-17)26-27-20(15)14-9-25-28(2)11-14/h5-7,9-11,23H,4,8H2,1-2H3,(H,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414772
PNG
(US10435405, Example 189 | US10435405, Example 190 ...)
Show SMILES CNC(C)c1cc(C)c(c(F)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414798
PNG
(US10435405, Example 215 | US10934288, Example 215)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2c1OC
Show InChI InChI=1S/C19H18F2N6O/c1-22-6-10-4-12(20)15(13(21)5-10)18-19(28-3)16-14(8-23-18)25-26-17(16)11-7-24-27(2)9-11/h4-5,7-9,22H,6H2,1-3H3,(H,25,26)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414806
PNG
(US10435405, Example 223 | US10934288, Example 223)
Show SMILES Cc1c(CNC2CC(C)(C)C2)ccc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H27FN6/c1-14-15(10-26-17-8-24(2,3)9-17)5-6-19(25)22(14)20-7-18-21(12-27-20)29-30-23(18)16-11-28-31(4)13-16/h5-7,11-13,17,26H,8-10H2,1-4H3,(H,29,30)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414814
PNG
(US10435405, Example 231 | US10934288, Example 231)
Show SMILES CCn1cc(cn1)-c1n[nH]c2cnc(cc12)-c1c(C)cc(cc1F)[C@H]1CCCCN1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414819
PNG
(US10435405, Example 236 | US10934288, Example 236)
Show SMILES CCNCc1ccc(F)c(c1C)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H21FN6/c1-4-22-8-13-5-6-16(21)19(12(13)2)17-7-15-18(10-23-17)25-26-20(15)14-9-24-27(3)11-14/h5-7,9-11,22H,4,8H2,1-3H3,(H,25,26)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414585
PNG
(US10435405, Example 4 | US10934288, Example 4)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3cccc(Br)c3)n[nH]c2cn1
Show InChI InChI=1S/C20H14BrFN4O2/c1-28-17-7-3-6-14(22)18(17)15-9-13-16(10-23-15)25-26-19(13)24-20(27)11-4-2-5-12(21)8-11/h2-10H,1H3,(H2,24,25,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414591
PNG
(US10435405, Example 9 | US10934288, Example 9)
Show SMILES COc1cccc(c1)C(=O)Nc1n[nH]c2cnc(cc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C21H17FN4O3/c1-28-13-6-3-5-12(9-13)21(27)24-20-14-10-16(23-11-17(14)25-26-20)19-15(22)7-4-8-18(19)29-2/h3-11H,1-2H3,(H2,24,25,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414597
PNG
(US10435405, Example 15 | US10934288, Example 15)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3ccn(C)n3)n[nH]c2cn1
Show InChI InChI=1S/C18H15FN6O2/c1-25-7-6-12(24-25)18(26)21-17-10-8-13(20-9-14(10)22-23-17)16-11(19)4-3-5-15(16)27-2/h3-9H,1-2H3,(H2,21,22,23,26)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414605
PNG
(US10435405, Example 23 | US10934288, Example 23)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3cccc(c3)N3CCNCC3)n[nH]c2cn1
Show InChI InChI=1S/C24H23FN6O2/c1-33-21-7-3-6-18(25)22(21)19-13-17-20(14-27-19)29-30-23(17)28-24(32)15-4-2-5-16(12-15)31-10-8-26-9-11-31/h2-7,12-14,26H,8-11H2,1H3,(H2,28,29,30,32)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM484510
PNG
(US10934288, Example 32)
Show SMILES COc1cccc(F)c1-c1cc2c(NC(=O)c3ccc(cc3)N3CCN(C(=O)C3)S(C)(=O)=O)n[nH]c2cn1
Show InChI InChI=1S/C25H23FN6O5S/c1-37-21-5-3-4-18(26)23(21)19-12-17-20(13-27-19)29-30-24(17)28-25(34)15-6-8-16(9-7-15)31-10-11-32(22(33)14-31)38(2,35)36/h3-9,12-13H,10-11,14H2,1-2H3,(H2,28,29,30,34)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414618
PNG
(US10435405, Example 35 | US10934288, Example 35)
Show SMILES COc1cccc(F)c1-c1cc2c(n[nH]c2cn1)-c1cc(C)no1
Show InChI InChI=1S/C17H13FN4O2/c1-9-6-15(24-22-9)17-10-7-12(19-8-13(10)20-21-17)16-11(18)4-3-5-14(16)23-2/h3-8H,1-2H3,(H,20,21)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414619
PNG
(US10435405, Example 36 | US10934288, Example 36)
Show SMILES COc1cccc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnc(C)s1
Show InChI InChI=1S/C17H13FN4OS/c1-9-19-8-15(24-9)17-10-6-12(20-7-13(10)21-22-17)16-11(18)4-3-5-14(16)23-2/h3-8H,1-2H3,(H,21,22)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414626
PNG
(US10435405, Example 43 | US10934288, Example 43)
Show SMILES COc1cccc(F)c1-c1cc2c(n[nH]c2cn1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H24FN5O/c1-29-10-12-30(13-11-29)17-8-6-16(7-9-17)24-18-14-20(26-15-21(18)27-28-24)23-19(25)4-3-5-22(23)31-2/h3-9,14-15H,10-13H2,1-2H3,(H,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414635
PNG
(US10435405, Example 52 | US10934288, Example 52)
Show SMILES COc1cccc(Cl)c1-c1cc2c(n[nH]c2cn1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H24ClN5O/c1-29-10-12-30(13-11-29)17-8-6-16(7-9-17)24-18-14-20(26-15-21(18)27-28-24)23-19(25)4-3-5-22(23)31-2/h3-9,14-15H,10-13H2,1-2H3,(H,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414637
PNG
(US10435405, Example 54 | US10934288, Example 54)
Show SMILES COc1cccc(F)c1-c1cc2c(n[nH]c2cn1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C25H25FN6O2/c1-31-10-12-32(13-11-31)17-8-6-16(7-9-17)28-25(33)24-18-14-20(27-15-21(18)29-30-24)23-19(26)4-3-5-22(23)34-2/h3-9,14-15H,10-13H2,1-2H3,(H,28,33)(H,29,30)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414641
PNG
(US10435405, Example 58 | US10934288, Example 58)
Show SMILES COC1CN(C1)C(=O)c1cc(F)c(c(F)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18F2N6O2/c1-28-8-12(6-25-28)20-14-5-17(24-7-18(14)26-27-20)19-15(22)3-11(4-16(19)23)21(30)29-9-13(10-29)31-2/h3-8,13H,9-10H2,1-2H3,(H,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414657
PNG
(US10435405, Example 74 | US10934288, Example 74)
Show SMILES COc1cc(NC(=O)CN2CCCC2)cc(F)c1-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24FN7O2/c1-30-12-14(10-26-30)23-16-9-18(25-11-19(16)28-29-23)22-17(24)7-15(8-20(22)33-2)27-21(32)13-31-5-3-4-6-31/h7-12H,3-6,13H2,1-2H3,(H,27,32)(H,28,29)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414660
PNG
(US10435405, Example 77 | US10934288, Example 77)
Show SMILES Cn1cc(cn1)-c1n[nH]c2cnc(cc12)-c1c(F)cc(NC(=O)CN2CCC2)c(F)c1F
Show InChI InChI=1S/C21H18F3N7O/c1-30-9-11(7-26-30)21-12-5-14(25-8-16(12)28-29-21)18-13(22)6-15(19(23)20(18)24)27-17(32)10-31-3-2-4-31/h5-9H,2-4,10H2,1H3,(H,27,32)(H,28,29)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414669
PNG
(US10435405, Example 86 | US10934288, Example 86)
Show SMILES CNCc1cccc(c1C)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C19H20N6/c1-12-13(8-20-2)5-4-6-15(12)17-7-16-18(10-21-17)23-24-19(16)14-9-22-25(3)11-14/h4-7,9-11,20H,8H2,1-3H3,(H,23,24)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414678
PNG
(US10435405, Example 95 | US10934288, Example 95)
Show SMILES CC(C)NC1CC(C1)c1cc(F)c(c(F)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24F2N6/c1-12(2)28-16-4-13(5-16)14-6-18(24)22(19(25)7-14)20-8-17-21(10-26-20)29-30-23(17)15-9-27-31(3)11-15/h6-13,16,28H,4-5H2,1-3H3,(H,29,30)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414688
PNG
(US10435405, Example 105 | US10934288, Example 105)
Show SMILES CNC(=O)c1cn(cn1)-c1n[nH]c2cnc(cc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C18H15FN6O2/c1-20-18(26)14-8-25(9-22-14)17-10-6-12(21-7-13(10)23-24-17)16-11(19)4-3-5-15(16)27-2/h3-9H,1-2H3,(H,20,26)(H,23,24)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414702
PNG
(US10435405, Example 119 | US10934288, Example 119)
Show SMILES CNCc1cc(F)c(-c2cc3c(n[nH]c3cn2)-c2ccc(nc2)N2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H25F4N7/c1-30-12-15-9-18(25(27,28)29)23(19(26)10-15)20-11-17-21(14-31-20)33-34-24(17)16-3-4-22(32-13-16)36-7-5-35(2)6-8-36/h3-4,9-11,13-14,30H,5-8,12H2,1-2H3,(H,33,34)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414706
PNG
(US10435405, Example 123 | US10934288, Example 123)
Show SMILES CC(C)NCc1cc(F)c(c(F)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H20F2N6/c1-11(2)23-7-12-4-15(21)19(16(22)5-12)17-6-14-18(9-24-17)26-27-20(14)13-8-25-28(3)10-13/h4-6,8-11,23H,7H2,1-3H3,(H,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM414709
PNG
(US10435405, Example 126 | US10934288, Example 126)
Show SMILES Cn1cc(cn1)-c1n[nH]c2cnc(cc12)-c1c(F)cc(CNCCO)cc1F
Show InChI InChI=1S/C19H18F2N6O/c1-27-10-12(8-24-27)19-13-6-16(23-9-17(13)25-26-19)18-14(20)4-11(5-15(18)21)7-22-2-3-28/h4-6,8-10,22,28H,2-3,7H2,1H3,(H,25,26)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10934288 (2021)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 241 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%