BindingDB logo
myBDB logout

Patent code US10934294

Compile Data Set for Download or QSAR
Found 124 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484570
PNG
(US10934294, Example 91 | US10934294, Example 92)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C1CC1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484497
PNG
(US10934294, Example 19 | US10934294, Example 20 | ...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484541
PNG
(US10934294, Example 62)
Show SMILES CCc1cnc(nc1)C1CCC1c1nc2n(nc(C#N)c2c(=O)[nH]1)[C@@H](C)c1ccc(nc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484551
PNG
(US10934294, Example 72 | US10934294, Example 73 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484572
PNG
(US10934294, Example 93)
Show SMILES C[C@@H](c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484593
PNG
(US10934294, Example 111)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@H]1c1nccc(C)n1
Show InChI InChI=1S/C23H19F3N8O/c1-11-7-8-28-19(30-11)14-4-5-15(14)20-31-21-18(22(35)32-20)16(9-27)33-34(21)12(2)13-3-6-17(29-10-13)23(24,25)26/h3,6-8,10,12,14-15H,4-5H2,1-2H3,(H,31,32,35)/t12-,14+,15-/m0/s1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484596
PNG
(US10934294, Example 114)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nccc(n1)C1CC1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484509
PNG
(US10934294, Example 31 | US10934294, Example 32 | ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(C)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484591
PNG
(US10934294, Example 110)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nccc(C)n1
Show InChI InChI=1S/C23H19F3N8O/c1-11-7-8-28-19(30-11)14-4-5-15(14)20-31-21-18(22(35)32-20)16(9-27)33-34(21)12(2)13-3-6-17(29-10-13)23(24,25)26/h3,6-8,10,12,14-15H,4-5H2,1-2H3,(H,31,32,35)/t12-,14-,15-/m0/s1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484539
PNG
(US10934294, Example 60 | US10934294, Example 61)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(OC(F)F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0800n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484559
PNG
(US10934294, Example 80 | US10934294, Example 81)
Show SMILES CC(c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.0900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484501
PNG
(US10934294, Example 23 | US10934294, Example 24 | ...)
Show SMILES CC(c1cccc(c1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484489
PNG
(US10934294, Example 11 | US10934294, Example 12 | ...)
Show SMILES CC(c1ccc(cc1)C#N)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484484
PNG
(US10934294, Example 6)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484537
PNG
(US10934294, Example 58 | US10934294, Example 59)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Br)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484594
PNG
(US10934294, Example 112)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nccc(n1)C(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484542
PNG
(US10934294, Example 63 | US10934294, Example 97)
Show SMILES COc1cnc(nc1)C1CCC1c1nc2n(nc(C#N)c2c(=O)[nH]1)[C@@H](C)c1ccc(nc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.150n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484583
PNG
(US10934294, Example 102 | US10934294, Example 103 ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.180n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484480
PNG
(US10934294, Example 2)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484587
PNG
(US10934294, Example 106 | US10934294, Example 107 ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Cl)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484525
PNG
(US10934294, Example 46 | US10934294, Example 47 | ...)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.220n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484561
PNG
(US10934294, Example 82)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C#C
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.230n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484563
PNG
(US10934294, Example 84)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.25n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484595
PNG
(US10934294, Example 113)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nc(cc(n1)C(C)(C)C)C(C)(C)C
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.270n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484569
PNG
(US10934294, Example 90)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(cn1)C#N
Show InChI InChI=1S/C23H16F3N9O/c1-11(13-2-5-17(29-10-13)23(24,25)26)35-21-18(16(7-28)34-35)22(36)33-20(32-21)15-4-3-14(15)19-30-8-12(6-27)9-31-19/h2,5,8-11,14-15H,3-4H2,1H3,(H,32,33,36)/t11-,14+,15+/m1/s1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484493
PNG
(US10934294, Example 15 | US10934294, Example 16 | ...)
Show SMILES CC(c1ccc(F)c(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484505
PNG
(US10934294, Example 27 | US10934294, Example 28 | ...)
Show SMILES CC(c1cnc(cn1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484567
PNG
(US10934294, Example 88)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1(C)CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.700n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.800n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484525
PNG
(US10934294, Example 46 | US10934294, Example 47 | ...)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
0.900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484555
PNG
(US10934294, Example 76 | US10934294, Example 77 | ...)
Show SMILES CC(c1cnc(s1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484513
PNG
(US10934294, Example 34 | US10934294, Example 35 | ...)
Show SMILES CC(c1cnc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484573
PNG
(US10934294, Example 94)
Show SMILES C[C@@H](c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484574
PNG
(US10934294, Example 95)
Show SMILES C[C@@H](c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484489
PNG
(US10934294, Example 11 | US10934294, Example 12 | ...)
Show SMILES CC(c1ccc(cc1)C#N)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484559
PNG
(US10934294, Example 80 | US10934294, Example 81)
Show SMILES CC(c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484579
PNG
(US10934294, Example 100 | US10934294, Example 101 ...)
Show SMILES C[C@@H](c1ccc(F)cn1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484501
PNG
(US10934294, Example 23 | US10934294, Example 24 | ...)
Show SMILES CC(c1cccc(c1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484497
PNG
(US10934294, Example 19 | US10934294, Example 20 | ...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484551
PNG
(US10934294, Example 72 | US10934294, Example 73 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484509
PNG
(US10934294, Example 31 | US10934294, Example 32 | ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(C)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
2.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484505
PNG
(US10934294, Example 27 | US10934294, Example 28 | ...)
Show SMILES CC(c1cnc(cn1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
2.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484485
PNG
(US10934294, Example 7)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
2.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484493
PNG
(US10934294, Example 15 | US10934294, Example 16 | ...)
Show SMILES CC(c1ccc(F)c(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484599
PNG
(US10934294, Example 117)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nccc(C)n1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
3.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484497
PNG
(US10934294, Example 19 | US10934294, Example 20 | ...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
4.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484486
PNG
(US10934294, Example 8)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
4.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484488
PNG
(US10934294, Example 10)
Show SMILES FC(F)(F)c1ccc(Cn2nc(C#N)c3c2nc([nH]c3=O)[C@H]2CC[C@@H]2c2ncccn2)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
4.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484482
PNG
(US10934294, Example 4)
Show SMILES C[C@H](c1ccc(F)cc1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
4.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484542
PNG
(US10934294, Example 63 | US10934294, Example 97)
Show SMILES COc1cnc(nc1)C1CCC1c1nc2n(nc(C#N)c2c(=O)[nH]1)[C@@H](C)c1ccc(nc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
5.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484551
PNG
(US10934294, Example 72 | US10934294, Example 73 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
6.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484598
PNG
(US10934294, Example 116)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nc([H]C(F)F)cc(n1)C(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
8.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
8.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484489
PNG
(US10934294, Example 11 | US10934294, Example 12 | ...)
Show SMILES CC(c1ccc(cc1)C#N)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
9.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484562
PNG
(US10934294, Example 83)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
10.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484493
PNG
(US10934294, Example 15 | US10934294, Example 16 | ...)
Show SMILES CC(c1ccc(F)c(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
11.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484497
PNG
(US10934294, Example 19 | US10934294, Example 20 | ...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
12.1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
12.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484483
PNG
(US10934294, Example 5)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
15.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484579
PNG
(US10934294, Example 100 | US10934294, Example 101 ...)
Show SMILES C[C@@H](c1ccc(F)cn1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484555
PNG
(US10934294, Example 76 | US10934294, Example 77 | ...)
Show SMILES CC(c1cnc(s1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
17.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484605
PNG
(US10934294, Example 123)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nccc(n1)C(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
19.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484505
PNG
(US10934294, Example 27 | US10934294, Example 28 | ...)
Show SMILES CC(c1cnc(cn1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
19.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484583
PNG
(US10934294, Example 102 | US10934294, Example 103 ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
21.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484602
PNG
(US10934294, Example 120)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nc(C)cc(C)n1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
23.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484603
PNG
(US10934294, Example 121)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1nccc(n1)C(C)(C)C
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
23.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484587
PNG
(US10934294, Example 106 | US10934294, Example 107 ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Cl)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
24n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484501
PNG
(US10934294, Example 23 | US10934294, Example 24 | ...)
Show SMILES CC(c1cccc(c1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
25n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484597
PNG
(US10934294, Example 115)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1nccc([H]C(F)F)n1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
25.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484587
PNG
(US10934294, Example 106 | US10934294, Example 107 ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Cl)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
26.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484537
PNG
(US10934294, Example 58 | US10934294, Example 59)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Br)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
26.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484479
PNG
(US10934294, Example 1)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
27.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484606
PNG
(US10934294, Example 124)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nccc(n1)C1CC1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
28.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484501
PNG
(US10934294, Example 23 | US10934294, Example 24 | ...)
Show SMILES CC(c1cccc(c1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
31.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484481
PNG
(US10934294, Example 3)
Show SMILES C[C@H](c1ccc(F)cc1)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
32.1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484583
PNG
(US10934294, Example 102 | US10934294, Example 103 ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
33.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484601
PNG
(US10934294, Example 119)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nccc(C)n1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
36.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484577
PNG
(US10934294, Example 96)
Show SMILES C[C@@H](c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@@H]1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
37.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484489
PNG
(US10934294, Example 11 | US10934294, Example 12 | ...)
Show SMILES CC(c1ccc(cc1)C#N)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
44.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484513
PNG
(US10934294, Example 34 | US10934294, Example 35 | ...)
Show SMILES CC(c1cnc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
50.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484551
PNG
(US10934294, Example 72 | US10934294, Example 73 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
54.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484570
PNG
(US10934294, Example 91 | US10934294, Example 92)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C1CC1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
55.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484543
PNG
(US10934294, Example 64 | US10934294, Example 65 | ...)
Show SMILES CC(c1cncc(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484547
PNG
(US10934294, Example 68 | US10934294, Example 69 | ...)
Show SMILES CC(c1cnn(C)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484547
PNG
(US10934294, Example 68 | US10934294, Example 69 | ...)
Show SMILES CC(c1cnn(C)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484547
PNG
(US10934294, Example 68 | US10934294, Example 69 | ...)
Show SMILES CC(c1cnn(C)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484543
PNG
(US10934294, Example 64 | US10934294, Example 65 | ...)
Show SMILES CC(c1cncc(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484543
PNG
(US10934294, Example 64 | US10934294, Example 65 | ...)
Show SMILES CC(c1cncc(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484547
PNG
(US10934294, Example 68 | US10934294, Example 69 | ...)
Show SMILES CC(c1cnn(C)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484543
PNG
(US10934294, Example 64 | US10934294, Example 65 | ...)
Show SMILES CC(c1cncc(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>67.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484600
PNG
(US10934294, Example 118)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nc(cc(n1)C(C)(C)C)C(C)(C)C
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
74.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
82.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484539
PNG
(US10934294, Example 60 | US10934294, Example 61)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(OC(F)F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
86.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484525
PNG
(US10934294, Example 46 | US10934294, Example 47 | ...)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
104n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484493
PNG
(US10934294, Example 15 | US10934294, Example 16 | ...)
Show SMILES CC(c1ccc(F)c(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484487
PNG
(US10934294, Example 9)
Show SMILES FC(F)(F)c1ccc(Cn2nc(C#N)c3c2nc([nH]c3=O)[C@@H]2CC[C@H]2c2ncccn2)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
124n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484568
PNG
(US10934294, Example 89)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@@H]1c1ncc(cn1)C#N
Show InChI InChI=1S/C23H16F3N9O/c1-11(13-2-5-17(29-10-13)23(24,25)26)35-21-18(16(7-28)34-35)22(36)33-20(32-21)15-4-3-14(15)19-30-8-12(6-27)9-31-19/h2,5,8-11,14-15H,3-4H2,1H3,(H,32,33,36)/t11-,14+,15-/m1/s1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
148n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484555
PNG
(US10934294, Example 76 | US10934294, Example 77 | ...)
Show SMILES CC(c1cnc(s1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
153n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484509
PNG
(US10934294, Example 31 | US10934294, Example 32 | ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(C)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
154n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484525
PNG
(US10934294, Example 46 | US10934294, Example 47 | ...)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
164n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484583
PNG
(US10934294, Example 102 | US10934294, Example 103 ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C(F)F
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
165n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484587
PNG
(US10934294, Example 106 | US10934294, Example 107 ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Cl)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
175n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484566
PNG
(US10934294, Example 87)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1(C)CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
250n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484505
PNG
(US10934294, Example 27 | US10934294, Example 28 | ...)
Show SMILES CC(c1cnc(cn1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
272n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484513
PNG
(US10934294, Example 34 | US10934294, Example 35 | ...)
Show SMILES CC(c1cnc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
319n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484579
PNG
(US10934294, Example 100 | US10934294, Example 101 ...)
Show SMILES C[C@@H](c1ccc(F)cn1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
321n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484604
PNG
(US10934294, Example 122)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nc(cc(n1)C(C)(C)C)C(C)(C)C
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
321n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484513
PNG
(US10934294, Example 34 | US10934294, Example 35 | ...)
Show SMILES CC(c1cnc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
329n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484555
PNG
(US10934294, Example 76 | US10934294, Example 77 | ...)
Show SMILES CC(c1cnc(s1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
354n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484579
PNG
(US10934294, Example 100 | US10934294, Example 101 ...)
Show SMILES C[C@@H](c1ccc(F)cn1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
392n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
493n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484564
PNG
(US10934294, Example 85 | US10934294, Example 86)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>607n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484564
PNG
(US10934294, Example 85 | US10934294, Example 86)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>607n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>608n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>608n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>608n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>608n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>608n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
>608n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%