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Patent code US10934310

Compile Data Set for Download or QSAR

Found 484 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485457
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-4-oxo-5-(5-phen...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cn4)c(=O)[nH]c1c23
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n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485461
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-4-oxo-5-(5- phe...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4ncc(Oc5ccccc5)cn4)c(=O)[nH]c1c23
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n/an/a 2.95n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485467
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-5-(*S)-(2-methy...)
Show SMILES Cc1nc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485460
PNG
(N-((1R,2S)-2-acrylamidocyclopentyl)-4-oxo-5-(5- ph...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ncc(Oc5ccccc5)cn4)c(=O)[nH]c1c23
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n/an/a 4.07n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485459
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-4-oxo-5-(5-phen...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4cnc(Oc5ccccc5)cn4)c(=O)[nH]c1c23
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n/an/a 4.07n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485458
PNG
(N-((1RS,2RS)-2-Acrylamidocyclopentyl)-5-(2-methyl-...)
Show SMILES C=CC(=O)N[C@@H]1CCC(C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)nc4)c(=O)[nH]c1c23
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n/an/a 4.17n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485600
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(4-(py...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccn5)cc4)c(=O)[nH]c1c23
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n/an/a 4.17n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485345
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(5-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cn4)c(=O)[nH]c1c23
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n/an/a 4.27n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485270
PNG
(N-((1R,2S)-2-acrylamidocyclopentyl)-4-oxo-5-(4-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23
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n/an/a 4.27n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485338
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-4-oxo-5-(6-phen...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)nc4)c(=O)[nH]c1c23
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n/an/a 4.47n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485333
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(6-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4cc(ncn4)-c4ccccc4)c(=O)[nH]c1c23
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n/an/a 4.57n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485367
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(5-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4cnc(Oc5ccccc5)cn4)c(=O)[nH]c1c23
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n/an/a 4.79n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485331
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*R)-(4-isop...)
Show SMILES CC(C)Oc1ccc(c(C)c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485387
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-5-(*S)-(6-cyclo...)
Show SMILES Cc1cc(OC2CCC2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 5.13n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485344
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(6-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)nc4)c(=O)[nH]c1c23
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n/an/a 5.25n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485340
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-5-(*R)-(4-isopr...)
Show SMILES CC(C)Oc1ccc(c(C)c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 5.25n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485464
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(*S)-(...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5cccnc5)cc4)c(=O)[nH]c1c23
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n/an/a 5.37n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485335
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(2-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccnc(c4)-c4ccccc4)c(=O)[nH]c1c23
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n/an/a 5.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485273
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*S)-(2-meth...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 5.62n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485536
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*S)-(6-isob...)
Show SMILES CC(C)COc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 5.62n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485466
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-4-oxo-5-(2- phe...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4cnc(Oc5ccccc5)nc4)c(=O)[nH]c1c23
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n/an/a 5.89n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485355
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(4-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4cc(ccn4)-c4ccccc4)c(=O)[nH]c1c23
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n/an/a 5.89n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485534
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*S)-(6-(cyc...)
Show SMILES Cc1cc(OC2CCCC2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 5.89n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485589
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*S)-(6-isop...)
Show SMILES CC(C)Oc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485463
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-5-(*S)-(6-isopr...)
Show SMILES CC(C)Oc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 6.46n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485337
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*S)-(4-meth...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 6.46n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485366
PNG
(N-((1R,2R)-2-Acrylamidocyclopentyl)-5-(*S)-(4-meth...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 6.61n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485593
PNG
(N-((1S,3R)-3-Acrylamidocyclopentyl)-5-(*S)-(4-meth...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@H]4CC[C@H](C4)NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 6.76n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485386
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(2-methyl-4-...)
Show SMILES Cc1cc(Oc2ccccn2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485332
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*S)-(4-meth...)
Show SMILES Cc1nc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485365
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(2-methyl-4-...)
Show SMILES Cc1cc(Oc2cccnc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 7.41n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485531
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(2-methyl-4-...)
Show SMILES Cc1cccc(Oc2ccc(c(C)c2)-n2c3ccnc4sc(C(=O)N[C@@H]5CCC[C@@H]5NC(=O)C=C)c([nH]c2=O)c34)n1
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n/an/a 7.41n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485284
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-4-oxo-5-(4-phen...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23
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Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485271
PNG
(N-((1R,2R)-2-Acrylamidocyclopentyl)-5-(*S)-(2-meth...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@H]4NC(=O)C=C)c([nH]c1=O)c23
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Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485334
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-4-oxo-5-(2-phen...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccnc(c4)-c4ccccc4)c(=O)[nH]c1c23
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Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485359
PNG
(5-([1,1'-Biphenyl]-3-yl)-N-((1R,2S)-2-acrylamidocy...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4cccc(c4)-c4ccccc4)c(=O)[nH]c1c23
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n/an/a 8.13n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485462
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(S)-(6-isobu...)
Show SMILES CC(C)Cc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 8.13n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485529
PNG
(N-((1R,3S)-3-Acrylamidocyclopentyl)-5-(*S)-(6-(cyc...)
Show SMILES Cc1cc(OC2CCCC2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CC[C@@H](C4)NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 8.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485272
PNG
(5-([1,1'-Biphenyl]-3-yl)-N-((1R,2S)-2-acrylamidocy...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1sc2nccc3n(-c4cccc(c4)-c4ccccc4)c(=O)[nH]c1c23
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n/an/a 8.71n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485532
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(4-((6-methy...)
Show SMILES Cc1cccc(Oc2ccc(cc2)-n2c3ccnc4sc(C(=O)N[C@@H]5CCC[C@@H]5NC(=O)C=C)c([nH]c2=O)c34)n1
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n/an/a 8.71n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485369
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(6-phe...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4cnnc(c4)-c4ccccc4)c(=O)[nH]c1c23
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n/an/a 8.71n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485341
PNG
(N-((1R,3R)-3-Acrylamidocyclopentyl)-5-(*S)-(2-meth...)
Show SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CC[C@H](C4)NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 8.91n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485522
PNG
(N-((1R,3S)-3-Acrylamidocyclopentyl)-5-(*S)-(4-meth...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CC[C@@H](C4)NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 8.91n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485470
PNG
(N-((1*S,3*S)-3-Acrylamidocyclopentyl)-5-(*S)-(4-me...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@H]4CC[C@@H](C4)NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 9.12n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485474
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-4-oxo-5-(2- ph...)
Show SMILES C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4cnc(Oc5ccccc5)nc4)c(=O)[nH]c1c23
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n/an/a 9.12n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485278
PNG
(5-(*S)-(2-Methyl-4-phenoxyphenyl)-N-((1R,2R)-2-(2-...)
Show SMILES CNCC(=O)N[C@@H]1CCC[C@H]1NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4C)c(=O)[nH]c1c23
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n/an/a 9.12n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485553
PNG
(5-(*S)-(4-Methyl-6-phenoxypyridin-3-yl)-4-oxo-N-((...)
Show SMILES CCC(=O)N[C@@H]1CC[C@@H](C1)NC(=O)c1sc2nccc3n(-c4cnc(Oc5ccccc5)cc4C)c(=O)[nH]c1c23
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n/an/a 9.12n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485370
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-5-(*S)-(6-cyclo...)
Show SMILES Cc1nc(OC2CCC2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
PDB
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n/an/a 9.33n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485601
PNG
(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(3-isopropyl...)
Show SMILES CC(C)c1cccc(c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
PDB
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n/an/a 9.55n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM485339
PNG
(N-((1R,2S)-2-Acrylamidocyclohexyl)-5-(*S)-(4-methy...)
Show SMILES Cc1cc(Oc2ccccc2)ncc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCCC[C@@H]4NC(=O)C=C)c([nH]c1=O)c23
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n/an/a 9.55n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...


US Patent US10934310 (2021)

More data for this
Ligand-Target Pair
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