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Patent code US10941129

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485688
PNG
(US10941129, Example 20)
Show SMILES OC[C@H](NCc1cc(Cl)c(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C31H26BrClN2O5/c32-30-23(10-5-11-25(30)22-8-2-1-3-9-22)19-40-29-14-28(39-18-21-7-4-6-20(12-21)15-34)24(13-26(29)33)16-35-27(17-36)31(37)38/h1-14,27,35-36H,16-19H2,(H,37,38)/t27-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 2.48n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485698
PNG
(N-(4-(2-bromo-3-phenylbenzyloxy)-5-chloro-2-(3-cya...)
Show SMILES C[C@@H](NCc1cc(Cl)c(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C31H26BrClN2O4/c1-20(31(36)37)35-17-25-14-27(33)29(15-28(25)38-18-22-8-5-7-21(13-22)16-34)39-19-24-11-6-12-26(30(24)32)23-9-3-2-4-10-23/h2-15,20,35H,17-19H2,1H3,(H,36,37)/t20-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 3.16n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485690
PNG
(N-hydroxylethyl-4-(2-bromo-3-phenylbenzyloxy)-5-ch...)
Show SMILES OCCNCc1cc(Cl)c(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C30H26BrClN2O3/c31-30-24(10-5-11-26(30)23-8-2-1-3-9-23)20-37-29-16-28(25(15-27(29)32)18-34-12-13-35)36-19-22-7-4-6-21(14-22)17-33/h1-11,14-16,34-35H,12-13,18-20H2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 5.29n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485699
PNG
(US10941129, Example 26)
Show SMILES C[C@H](O)[C@@H](NCc1cc(Cl)c(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H28BrClN2O5/c1-20(37)31(32(38)39)36-17-25-14-27(34)29(15-28(25)40-18-22-8-5-7-21(13-22)16-35)41-19-24-11-6-12-26(30(24)33)23-9-3-2-4-10-23/h2-15,20,31,36-37H,17-19H2,1H3,(H,38,39)/t20-,31+/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485701
PNG
(N-(4-(2-bromo-3-phenylbenzyloxy)-5-chloro-2-(3-met...)
Show SMILES CS(=O)(=O)c1cccc(COc2cc(OCc3cccc(c3Br)-c3ccccc3)c(Cl)cc2CN[C@H](CO)C(O)=O)c1
Show InChI InChI=1S/C31H29BrClNO7S/c1-42(38,39)24-11-5-7-20(13-24)18-40-28-15-29(26(33)14-23(28)16-34-27(17-35)31(36)37)41-19-22-10-6-12-25(30(22)32)21-8-3-2-4-9-21/h2-15,27,34-35H,16-19H2,1H3,(H,36,37)/t27-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485703
PNG
(N-(4-(2-bromo-3-phenylbenzyloxy)-5-chloro-2-(3-met...)
Show SMILES CS(=O)(=O)c1cccc(COc2cc(OCc3cccc(c3Br)-c3ccccc3)c(Cl)cc2CN2CCCC[C@H]2C(O)=O)c1
Show InChI InChI=1S/C34H33BrClNO6S/c1-44(40,41)27-13-7-9-23(17-27)21-42-31-19-32(29(36)18-26(31)20-37-16-6-5-15-30(37)34(38)39)43-22-25-12-8-14-28(33(25)35)24-10-3-2-4-11-24/h2-4,7-14,17-19,30H,5-6,15-16,20-22H2,1H3,(H,38,39)/t30-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485686
PNG
(N-(4-(2-bromo-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-...)
Show SMILES C[C@H](O)[C@@H](NCc1ccc(OCc2cccc(c2Br)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C34H31BrN2O7/c1-21(38)33(34(39)40)37-18-25-8-10-27(16-30(25)44-19-23-5-2-4-22(14-23)17-36)43-20-26-6-3-7-28(32(26)35)24-9-11-29-31(15-24)42-13-12-41-29/h2-11,14-16,21,33,37-38H,12-13,18-20H2,1H3,(H,39,40)/t21-,33+/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 18.1n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485679
PNG
(US10941129, Example 2)
Show SMILES OC[C@H](NCc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C31H27BrN2O5/c32-30-25(10-5-11-27(30)23-8-2-1-3-9-23)20-38-26-13-12-24(17-34-28(18-35)31(36)37)29(15-26)39-19-22-7-4-6-21(14-22)16-33/h1-15,28,34-35H,17-20H2,(H,36,37)/t28-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 29.4n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485684
PNG
(N-(4-(2-bromo-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-...)
Show SMILES OC[C@H](NCc1ccc(OCc2cccc(c2Br)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H29BrN2O7/c34-32-25(5-2-6-27(32)23-8-10-29-31(14-23)41-12-11-40-29)20-42-26-9-7-24(17-36-28(18-37)33(38)39)30(15-26)43-19-22-4-1-3-21(13-22)16-35/h1-10,13-15,28,36-37H,11-12,17-20H2,(H,38,39)/t28-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 38.5n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485683
PNG
(US10941129, Example 4)
Show SMILES OC(=O)[C@@H]1CCCN1Cc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C33H29BrN2O4/c34-32-27(11-5-12-29(32)25-9-2-1-3-10-25)22-39-28-15-14-26(20-36-16-6-13-30(36)33(37)38)31(18-28)40-21-24-8-4-7-23(17-24)19-35/h1-5,7-12,14-15,17-18,30H,6,13,16,20-22H2,(H,37,38)/t30-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 59.2n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM470337
PNG
(US10815208, Example 2 | US10941129, Example 22)
Show SMILES CC(=O)NCCNCc1cc(Cl)c(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C32H29BrClN3O3/c1-22(38)37-14-13-36-19-27-16-29(34)31(17-30(27)39-20-24-8-5-7-23(15-24)18-35)40-21-26-11-6-12-28(32(26)33)25-9-3-2-4-10-25/h2-12,15-17,36H,13-14,19-21H2,1H3,(H,37,38)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 62.3n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485696
PNG
((S)óN-(4-(2-bromo-3-(2,3-dihydrobenzo[b][1,4]dioxi...)
Show SMILES OC(=O)[C@@H]1CCCCN1Cc1cc(Cl)c(OCc2cccc(c2Br)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C36H32BrClN2O6/c37-35-26(7-4-8-28(35)25-10-11-31-34(17-25)44-14-13-43-31)22-46-33-18-32(45-21-24-6-3-5-23(15-24)19-39)27(16-29(33)38)20-40-12-2-1-9-30(40)36(41)42/h3-8,10-11,15-18,30H,1-2,9,12-14,20-22H2,(H,41,42)/t30-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 67.5n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485691
PNG
(US10941129, Example 8)
Show SMILES C[C@H](O)[C@@H](NCc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C32H29BrN2O5/c1-21(36)31(32(37)38)35-18-25-13-14-27(16-29(25)40-19-23-8-5-7-22(15-23)17-34)39-20-26-11-6-12-28(30(26)33)24-9-3-2-4-10-24/h2-16,21,31,35-36H,18-20H2,1H3,(H,37,38)/t21-,31+/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 134n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485687
PNG
(US10941129, Example 6)
Show SMILES C[C@H](NCc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C31H27BrN2O4/c1-21(31(35)36)34-18-25-13-14-27(16-29(25)38-19-23-8-5-7-22(15-23)17-33)37-20-26-11-6-12-28(30(26)32)24-9-3-2-4-10-24/h2-16,21,34H,18-20H2,1H3,(H,35,36)/t21-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 178n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485681
PNG
(N-Ethyl-N-hydroxylethyl-4-(2-bromo-3-phenylbenzylo...)
Show SMILES CCN(CCO)Cc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C32H31BrN2O3/c1-2-35(16-17-36)21-27-14-15-29(19-31(27)38-22-25-9-6-8-24(18-25)20-34)37-23-28-12-7-13-30(32(28)33)26-10-4-3-5-11-26/h3-15,18-19,36H,2,16-17,21-23H2,1H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 230n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485680
PNG
(N-acetylaminoethyl-4-(2-bromo-3-(2,3-dihydrobenzo[...)
Show SMILES CC(=O)NCCNCc1ccc(OCc2cccc(c2Br)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C34H32BrN3O5/c1-23(39)38-13-12-37-20-27-8-10-29(18-32(27)43-21-25-5-2-4-24(16-25)19-36)42-22-28-6-3-7-30(34(28)35)26-9-11-31-33(17-26)41-15-14-40-31/h2-11,16-18,37H,12-15,20-22H2,1H3,(H,38,39)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 268n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485685
PNG
(N-hydroxylethyl-4-(2-bromo-3-phenylbenzyloxy)-2-(3...)
Show SMILES OCCNCc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C30H27BrN2O3/c31-30-26(10-5-11-28(30)24-8-2-1-3-9-24)21-35-27-13-12-25(19-33-14-15-34)29(17-27)36-20-23-7-4-6-22(16-23)18-32/h1-13,16-17,33-34H,14-15,19-21H2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 307n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485678
PNG
(N-acetylaminoethyl-4-(2-bromo-3-phenylbenzyloxy)-2...)
Show SMILES CC(=O)NCCNCc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C32H30BrN3O3/c1-23(37)36-16-15-35-20-27-13-14-29(18-31(27)39-21-25-8-5-7-24(17-25)19-34)38-22-28-11-6-12-30(32(28)33)26-9-3-2-4-10-26/h2-14,17-18,35H,15-16,20-22H2,1H3,(H,36,37)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a 439n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485695
PNG
(US10941129, Example 10)
Show SMILES Brc1c(COc2ccc(CN3CCOCC3)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccccc1
Show InChI InChI=1S/C32H29BrN2O3/c33-32-28(10-5-11-30(32)26-8-2-1-3-9-26)23-37-29-13-12-27(21-35-14-16-36-17-15-35)31(19-29)38-22-25-7-4-6-24(18-25)20-34/h1-13,18-19H,14-17,21-23H2
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n/an/a 458n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485693
PNG
(N-(tetrahydro-2H-pyran-4-yl)-4-(2-bromo-3-phenylbe...)
Show SMILES Brc1c(COc2ccc(CNC3CCOCC3)c(OCc3cccc(c3)C#N)c2)cccc1-c1ccccc1
Show InChI InChI=1S/C33H31BrN2O3/c34-33-28(10-5-11-31(33)26-8-2-1-3-9-26)23-38-30-13-12-27(21-36-29-14-16-37-17-15-29)32(19-30)39-22-25-7-4-6-24(18-25)20-35/h1-13,18-19,29,36H,14-17,21-23H2
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n/an/a 788n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485694
PNG
(N-(2-methanesulfonylaminoethyl)-4-(2-bromo-3-pheny...)
Show SMILES CS(=O)(=O)NCCNCc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C31H30BrN3O4S/c1-40(36,37)35-16-15-34-20-26-13-14-28(18-30(26)39-21-24-8-5-7-23(17-24)19-33)38-22-27-11-6-12-29(31(27)32)25-9-3-2-4-10-25/h2-14,17-18,34-35H,15-16,20-22H2,1H3
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n/an/a 979n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485682
PNG
(N-(4-(2-bromo-3-(3,4-dimethoxyphenyl)benzyloxy)-2-...)
Show SMILES COc1ccc(cc1OC)-c1cccc(COc2ccc(CN[C@@H](C)C(O)=O)c(OCc3cccc(c3)C#N)c2)c1Br
Show InChI InChI=1S/C33H31BrN2O6/c1-21(33(37)38)36-18-25-10-12-27(16-30(25)42-19-23-7-4-6-22(14-23)17-35)41-20-26-8-5-9-28(32(26)34)24-11-13-29(39-2)31(15-24)40-3/h4-16,21,36H,18-20H2,1-3H3,(H,37,38)/t21-/m0/s1
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n/an/a 3.16E+3n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485689
PNG
(US10941129, Example 7)
Show SMILES CSCC[C@H](NCc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C33H31BrN2O4S/c1-41-16-15-30(33(37)38)36-20-26-13-14-28(18-31(26)40-21-24-8-5-7-23(17-24)19-35)39-22-27-11-6-12-29(32(27)34)25-9-3-2-4-10-25/h2-14,17-18,30,36H,15-16,20-22H2,1H3,(H,37,38)/t30-/m0/s1
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n/an/a 4.59E+3n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485700
PNG
(N-(4-(2-bromo-3-(3,4-dimethoxyphenyl)benzyloxy)-2-...)
Show SMILES COc1ccc(cc1OC)-c1cccc(COc2ccc(CN[C@@H](CO)C(O)=O)c(OCc3cccc(c3)C#N)c2)c1Br
Show InChI InChI=1S/C33H31BrN2O7/c1-40-29-12-10-23(14-31(29)41-2)27-8-4-7-25(32(27)34)20-42-26-11-9-24(17-36-28(18-37)33(38)39)30(15-26)43-19-22-6-3-5-21(13-22)16-35/h3-15,28,36-37H,17-20H2,1-2H3,(H,38,39)/t28-/m0/s1
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n/an/a 5.35E+3n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485702
PNG
(N-acetylaminoethyl-4-(2-bromo-3-(3,4-dimethoxyphen...)
Show SMILES COc1ccc(cc1OC)-c1cccc(COc2ccc(CNCCNC(C)=O)c(OCc3cccc(c3)C#N)c2)c1Br
Show InChI InChI=1S/C34H34BrN3O5/c1-23(39)38-15-14-37-20-27-10-12-29(18-32(27)43-21-25-7-4-6-24(16-25)19-36)42-22-28-8-5-9-30(34(28)35)26-11-13-31(40-2)33(17-26)41-3/h4-13,16-18,37H,14-15,20-22H2,1-3H3,(H,38,39)
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n/an/a 6.65E+3n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
PD-1/PD-L1


(Homo sapiens-Homo sapiens (Human))
BDBM485697
PNG
(N-hydroxylethyl-4-(2-bromo-3-(3,4-dimethoxyphenyl)...)
Show SMILES COc1ccc(cc1OC)-c1cccc(COc2ccc(CNCCO)c(OCc3cccc(c3)C#N)c2)c1Br
Show InChI InChI=1S/C32H31BrN2O5/c1-37-29-12-10-24(16-31(29)38-2)28-8-4-7-26(32(28)33)21-39-27-11-9-25(19-35-13-14-36)30(17-27)40-20-23-6-3-5-22(15-23)18-34/h3-12,15-17,35-36H,13-14,19-21H2,1-2H3
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n/an/a 7.87E+3n/an/an/an/an/an/a



Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD

US Patent


Assay Description
1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...


US Patent US10941129 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%