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Patent code US10941138

Compile Data Set for Download or QSAR
Found 193 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485754
PNG
((R)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485761
PNG
((R)-N-methyl-3-((1- methylisoquinolin-5- yl)oxy)-3...)
Show SMILES CNCC[C@@H](Oc1cccc2c(C)nccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-14-5-3-6-16(15(14)8-11-20-13)21-17(9-10-19-2)18-7-4-12-22-18/h3-8,11-12,17,19H,9-10H2,1-2H3/t17-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485758
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiophen-3- y...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485780
PNG
((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485780
PNG
((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485768
PNG
((R)-3-((2,4- dimethylquinolin-5- yl)oxy)-N-methyl-...)
Show SMILES CNCC[C@@H](Oc1cccc2nc(C)cc(C)c12)c1cccs1
Show InChI InChI=1S/C19H22N2OS/c1-13-12-14(2)21-15-6-4-7-17(19(13)15)22-16(9-10-20-3)18-8-5-11-23-18/h4-8,11-12,16,20H,9-10H2,1-3H3/t16-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485747
PNG
(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485711
PNG
((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3/t16-/m0/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485713
PNG
((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485770
PNG
((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m0/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485692
PNG
(US10941138, Example 1)
Show SMILES CNCCC(Oc1cccc2cccnc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-14(16-8-4-12-21-16)20-15-7-2-5-13-6-3-10-19-17(13)15/h2-8,10,12,14,18H,9,11H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485747
PNG
(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485764
PNG
((R)-N-methyl-3-((1- methylisoquinolin-8- yl)oxy)-3...)
Show SMILES CNCC[C@@H](Oc1cccc2ccnc(C)c12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-18-14(8-11-20-13)5-3-6-16(18)21-15(9-10-19-2)17-7-4-12-22-17/h3-8,11-12,15,19H,9-10H2,1-2H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485748
PNG
(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485754
PNG
((R)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485755
PNG
((R)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485791
PNG
((R)-5-(3-(ethylamino)-1- (thiophen-2- yl)propoxy)i...)
Show SMILES CCNCC[C@@H](Oc1cccc2c(nccc12)C#N)c1cccs1
Show InChI InChI=1S/C19H19N3OS/c1-2-21-10-9-18(19-7-4-12-24-19)23-17-6-3-5-14-15(17)8-11-22-16(14)13-20/h3-8,11-12,18,21H,2,9-10H2,1H3/t18-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485705
PNG
(3-(isoquinolin-5-yloxy)- N-methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485784
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-5-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485744
PNG
(3-(5-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485752
PNG
((S)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m0/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485764
PNG
((R)-N-methyl-3-((1- methylisoquinolin-8- yl)oxy)-3...)
Show SMILES CNCC[C@@H](Oc1cccc2ccnc(C)c12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-18-14(8-11-20-13)5-3-6-16(18)21-15(9-10-19-2)17-7-4-12-22-17/h3-8,11-12,15,19H,9-10H2,1-2H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485744
PNG
(3-(5-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485707
PNG
(N-ethyl-3-(isoquinolin-5- yloxy)-3-(thiophen-2- yl...)
Show SMILES CCNCCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-2-19-11-9-17(18-7-4-12-22-18)21-16-6-3-5-14-13-20-10-8-15(14)16/h3-8,10,12-13,17,19H,2,9,11H2,1H3
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485711
PNG
((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3/t16-/m0/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485755
PNG
((R)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485718
PNG
(5-(3-(methylamino)-1- (thiophen-2- yl)propoxy)isoq...)
Show SMILES CNCCC(Oc1cccc2c(nccc12)C(N)=O)c1cccs1
Show InChI InChI=1S/C18H19N3O2S/c1-20-9-8-15(16-6-3-11-24-16)23-14-5-2-4-13-12(14)7-10-21-17(13)18(19)22/h2-7,10-11,15,20H,8-9H2,1H3,(H2,19,22)
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<100n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485759
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(thiophen-3- yl)p...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-7-16(13-8-11-21-12-13)20-17-6-2-5-15-14(17)4-3-9-19-15/h2-6,8-9,11-12,16,18H,7,10H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485748
PNG
(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485751
PNG
(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-7-10-20-11-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485793
PNG
((S)-5-(3-(ethylamino)-1- (thiophen-2- yl)propoxy)i...)
Show SMILES CCNCC[C@H](Oc1cccc2c(nccc12)C#N)c1cccs1
Show InChI InChI=1S/C19H19N3OS/c1-2-21-10-9-18(19-7-4-12-24-19)23-17-6-3-5-14-15(17)8-11-22-16(14)13-20/h3-8,11-12,18,21H,2,9-10H2,1H3/t18-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485715
PNG
((R)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485716
PNG
((R)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485747
PNG
(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485763
PNG
((R)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485774
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(thiazol-2- yl)pr...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-9-7-15(16-19-10-11-21-16)20-14-6-2-5-13-12(14)4-3-8-18-13/h2-6,8,10-11,15,17H,7,9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485782
PNG
((S)-3-(5-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-7-10-20-11-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485760
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(thiophen-3- y...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485774
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(thiazol-2- yl)pr...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-9-7-15(16-19-10-11-21-16)20-14-6-2-5-13-12(14)4-3-8-18-13/h2-6,8,10-11,15,17H,7,9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485716
PNG
((R)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485704
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(thiophen-2- yl)p...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485717
PNG
((R)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485720
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(tetrahydro-2H...)
Show SMILES CNCCC(Oc1cccc2cnccc12)C1CCOCC1
Show InChI InChI=1S/C18H24N2O2/c1-19-9-6-17(14-7-11-21-12-8-14)22-18-4-2-3-15-13-20-10-5-16(15)18/h2-5,10,13-14,17,19H,6-9,11-12H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485753
PNG
((S)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485762
PNG
((R)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485758
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiophen-3- y...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485790
PNG
((R)-N-ethyl-3-(isoquinolin- 5-yloxy)-3-(thiophen-2...)
Show SMILES CCNCC[C@@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-2-19-11-9-17(18-7-4-12-22-18)21-16-6-3-5-14-13-20-10-8-15(14)16/h3-8,10,12-13,17,19H,2,9,11H2,1H3/t17-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485750
PNG
(3-(3-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485719
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(pyridin-3- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cccnc1
Show InChI InChI=1S/C18H19N3O/c1-19-10-8-17(15-5-3-9-20-13-15)22-18-6-2-4-14-12-21-11-7-16(14)18/h2-7,9,11-13,17,19H,8,10H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485743
PNG
(3-(5-chlorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485748
PNG
(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485751
PNG
(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-7-10-20-11-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485753
PNG
((S)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485758
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiophen-3- y...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485760
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(thiophen-3- y...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485773
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiazol-2- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-7-6-15(16-19-9-10-21-16)20-14-4-2-3-12-11-18-8-5-13(12)14/h2-5,8-11,15,17H,6-7H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485782
PNG
((S)-3-(5-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-7-10-20-11-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485784
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-5-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485765
PNG
((R)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-3- ...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-7-16(13-8-11-21-12-13)20-17-6-2-5-15-14(17)4-3-9-19-15/h2-6,8-9,11-12,16,18H,7,10H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485715
PNG
((R)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485734
PNG
(N-methyl-3-(4- methylthiazol-2-yl)-3- (quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1nc(C)cs1
Show InChI InChI=1S/C17H19N3OS/c1-12-11-22-17(20-12)16(8-10-18-2)21-15-7-3-6-14-13(15)5-4-9-19-14/h3-7,9,11,16,18H,8,10H2,1-2H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485795
PNG
((R)-N-ethyl-3-(quinolin-5- yloxy)-3-(thiophen-2- y...)
Show SMILES CCNCC[C@@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-2-19-12-10-17(18-9-5-13-22-18)21-16-8-3-7-15-14(16)6-4-11-20-15/h3-9,11,13,17,19H,2,10,12H2,1H3/t17-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485704
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(thiophen-2- yl)p...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485712
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485749
PNG
(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485756
PNG
(3-(isoquinolin-6-yloxy)-N- methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1ccc2cnccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-7-16(17-3-2-10-21-17)20-15-5-4-14-12-19-9-6-13(14)11-15/h2-6,9-12,16,18H,7-8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485762
PNG
((R)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485767
PNG
((S)-N-methyl-3-((1- methylisoquinolin-5- yl)oxy)-3...)
Show SMILES CNCC[C@H](Oc1cccc2c(C)nccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-14-5-3-6-16(15(14)8-11-20-13)21-17(9-10-19-2)18-7-4-12-22-18/h3-8,11-12,17,19H,9-10H2,1-2H3/t17-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485796
PNG
((R)-N-methyl-3-(quinolin- 3-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@@H](Oc1cnc2ccccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-7-4-10-21-17)20-14-11-13-5-2-3-6-15(13)19-12-14/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485743
PNG
(3-(5-chlorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485792
PNG
((S)-N-ethyl-3-(quinolin-5- yloxy)-3-(thiophen-2- y...)
Show SMILES CCNCC[C@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-2-19-12-10-17(18-9-5-13-22-18)21-16-8-3-7-15-14(16)6-4-11-20-15/h3-9,11,13,17,19H,2,10,12H2,1H3/t17-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485746
PNG
(3-(isoquinolin-5-yloxy)-3- (thiophen-2-yl)propan-1...)
Show SMILES NCCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C16H16N2OS/c17-8-6-15(16-5-2-10-20-16)19-14-4-1-3-12-11-18-9-7-13(12)14/h1-5,7,9-11,15H,6,8,17H2
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485769
PNG
((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-3- ...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-7-16(13-8-11-21-12-13)20-17-6-2-5-15-14(17)4-3-9-19-15/h2-6,8-9,11-12,16,18H,7,10H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485763
PNG
((R)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485777
PNG
(US10941138, Example 75)
Show SMILES CNCCC(Oc1cccc2c(nccc12)C#N)c1cccs1
Show InChI InChI=1S/C18H17N3OS/c1-20-9-8-17(18-6-3-11-23-18)22-16-5-2-4-13-14(16)7-10-21-15(13)12-19/h2-7,10-11,17,20H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485782
PNG
((S)-3-(5-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-7-10-20-11-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485749
PNG
(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485712
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485704
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(thiophen-2- yl)p...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485717
PNG
((R)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485715
PNG
((R)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485743
PNG
(3-(5-chlorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485744
PNG
(3-(5-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485750
PNG
(3-(3-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485763
PNG
((R)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485786
PNG
((S)-3-(3-Fluorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485786
PNG
((S)-3-(3-Fluorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485788
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485753
PNG
((S)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485778
PNG
((S)óN-Methyl-3-(quinolin-5-yloxy)-3-(thiazol-2-yl)...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-9-7-15(16-19-10-11-21-16)20-14-6-2-5-13-12(14)4-3-8-18-13/h2-6,8,10-11,15,17H,7,9H2,1H3/t15-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485705
PNG
(3-(isoquinolin-5-yloxy)- N-methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485712
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485716
PNG
((R)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485727
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(pyridin-4- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccncc1
Show InChI InChI=1S/C18H19N3O/c1-19-9-8-17(14-5-10-20-11-6-14)22-18-4-2-3-15-13-21-12-7-16(15)18/h2-7,10-13,17,19H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485749
PNG
(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485750
PNG
(3-(3-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485755
PNG
((R)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485776
PNG
(3-(isoquinolin-7-yloxy)-N- methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1ccc2ccncc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-7-16(17-3-2-10-21-17)20-15-5-4-13-6-9-19-12-14(13)11-15/h2-6,9-12,16,18H,7-8H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485784
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-5-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485784
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-5-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485788
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485788
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485762
PNG
((R)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485788
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485769
PNG
((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-3- ...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-7-16(13-8-11-21-12-13)20-17-6-2-5-15-14(17)4-3-9-19-15/h2-6,8-9,11-12,16,18H,7,10H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485705
PNG
(3-(isoquinolin-5-yloxy)- N-methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485717
PNG
((R)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3/t16-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485751
PNG
(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-7-10-20-11-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485754
PNG
((R)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Show SMILES CNCC[C@@H](Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485769
PNG
((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-3- ...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-7-16(13-8-11-21-12-13)20-17-6-2-5-15-14(17)4-3-9-19-15/h2-6,8-9,11-12,16,18H,7,10H2,1H3/t16-/m0/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485780
PNG
((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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300n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485764
PNG
((R)-N-methyl-3-((1- methylisoquinolin-8- yl)oxy)-3...)
Show SMILES CNCC[C@@H](Oc1cccc2ccnc(C)c12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-18-14(8-11-20-13)5-3-6-16(18)21-15(9-10-19-2)17-7-4-12-22-17/h3-8,11-12,15,19H,9-10H2,1-2H3/t15-/m1/s1
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485780
PNG
((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485711
PNG
((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-16(17-8-4-12-21-17)20-15-7-2-6-14-13(15)5-3-10-19-14/h2-8,10,12,16,18H,9,11H2,1H3/t16-/m0/s1
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485771
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m0/s1
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485732
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(4- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-8-7-18(16-11-14(6-10-25-16)19(20,21)22)26-17-4-2-3-13-5-9-24-12-15(13)17/h2-6,9-12,18,23H,7-8H2,1H3
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485774
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(thiazol-2- yl)pr...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-9-7-15(16-19-10-11-21-16)20-14-6-2-5-13-12(14)4-3-8-18-13/h2-6,8,10-11,15,17H,7,9H2,1H3
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485760
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(thiophen-3- y...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)
BDBM485712
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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750n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485778
PNG
((S)óN-Methyl-3-(quinolin-5-yloxy)-3-(thiazol-2-yl)...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-9-7-15(16-19-10-11-21-16)20-14-6-2-5-13-12(14)4-3-8-18-13/h2-6,8,10-11,15,17H,7,9H2,1H3/t15-/m0/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485757
PNG
((S)-3-(isoquinolin-6- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1ccc2cnccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-7-16(17-3-2-10-21-17)20-15-5-4-14-12-19-9-6-13(14)11-15/h2-6,9-12,16,18H,7-8H2,1H3/t16-/m0/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485782
PNG
((S)-3-(5-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@@H](Oc1cccc2ccncc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-7-10-20-11-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m1/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485773
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiazol-2- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-7-6-15(16-19-9-10-21-16)20-14-4-2-3-12-11-18-8-5-13(12)14/h2-5,8-11,15,17H,6-7H2,1H3
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485786
PNG
((S)-3-(3-Fluorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3/t16-/m0/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485752
PNG
((S)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m0/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485756
PNG
(3-(isoquinolin-6-yloxy)-N- methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1ccc2cnccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-7-16(17-3-2-10-21-17)20-15-5-4-14-12-19-9-6-13(14)11-15/h2-6,9-12,16,18H,7-8H2,1H3
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485773
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiazol-2- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-7-6-15(16-19-9-10-21-16)20-14-4-2-3-12-11-18-8-5-13(12)14/h2-5,8-11,15,17H,6-7H2,1H3
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485786
PNG
((S)-3-(3-Fluorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3/t16-/m0/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485745
PNG
(3-(isoquinolin-5-yloxy)- N,N-dimethyl-3-(thiophen-...)
Show SMILES CN(C)CCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-20(2)11-9-17(18-7-4-12-22-18)21-16-6-3-5-14-13-19-10-8-15(14)16/h3-8,10,12-13,17H,9,11H2,1-2H3
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485736
PNG
(N-methyl-3-(5- methylthiazol-2-yl)-3- (quinolin-5-...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ncc(C)s1
Show InChI InChI=1S/C17H19N3OS/c1-12-11-20-17(22-12)16(8-10-18-2)21-15-7-3-6-14-13(15)5-4-9-19-14/h3-7,9,11,16,18H,8,10H2,1-2H3
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485780
PNG
((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485786
PNG
((S)-3-(3-Fluorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3/t16-/m0/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485775
PNG
(N-methyl-3-(quinolin-7- yloxy)-3-(thiophen-2- yl)p...)
Show SMILES CNCCC(Oc1ccc2cccnc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-8-16(17-5-3-11-21-17)20-14-7-6-13-4-2-9-19-15(13)12-14/h2-7,9,11-12,16,18H,8,10H2,1H3
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485786
PNG
((S)-3-(3-Fluorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@H](Oc1cccc2ncccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-10-7-16(17-13(18)8-11-22-17)21-15-6-2-5-14-12(15)4-3-9-20-14/h2-6,8-9,11,16,19H,7,10H2,1H3/t16-/m0/s1
PDB

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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485752
PNG
((S)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1ccc(F)s1
Show InChI InChI=1S/C17H17FN2OS/c1-19-9-8-15(16-5-6-17(18)22-16)21-14-4-2-3-12-11-20-10-7-13(12)14/h2-7,10-11,15,19H,8-9H2,1H3/t15-/m0/s1
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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485756
PNG
(3-(isoquinolin-6-yloxy)-N- methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1ccc2cnccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-7-16(17-3-2-10-21-17)20-15-5-4-14-12-19-9-6-13(14)11-15/h2-6,9-12,16,18H,7-8H2,1H3
PDB

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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485780
PNG
((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Show SMILES CNCC[C@@H](Oc1cccc2ncccc12)c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2OS/c1-19-11-9-15(16-7-8-17(18)22-16)21-14-6-2-5-13-12(14)4-3-10-20-13/h2-8,10,15,19H,9,11H2,1H3/t15-/m1/s1
PDB

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1.75E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485772
PNG
(US10941138, Example 70)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1nccs1
Show InChI InChI=1S/C16H17N3OS/c1-17-7-6-15(16-19-9-10-21-16)20-14-4-2-3-12-5-8-18-11-13(12)14/h2-5,8-11,15,17H,6-7H2,1H3
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485767
PNG
((S)-N-methyl-3-((1- methylisoquinolin-5- yl)oxy)-3...)
Show SMILES CNCC[C@H](Oc1cccc2c(C)nccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-14-5-3-6-16(15(14)8-11-20-13)21-17(9-10-19-2)18-7-4-12-22-18/h3-8,11-12,17,19H,9-10H2,1-2H3/t17-/m0/s1
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485722
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(tetrahydro-2H- p...)
Show SMILES CNCCC(Oc1cccc2ncccc12)C1CCOCC1
Show InChI InChI=1S/C18H24N2O2/c1-19-11-7-17(14-8-12-21-13-9-14)22-18-6-2-5-16-15(18)4-3-10-20-16/h2-6,10,14,17,19H,7-9,11-13H2,1H3
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485730
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(6- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-9-8-16(14-5-6-18(25-12-14)19(20,21)22)26-17-4-2-3-13-11-24-10-7-15(13)17/h2-7,10-12,16,23H,8-9H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485738
PNG
(N-methyl-3-(pyridin-3-yl)- 3-(quinolin-5- yloxy)pr...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1cccnc1
Show InChI InChI=1S/C18H19N3O/c1-19-12-9-17(14-5-3-10-20-13-14)22-18-8-2-7-16-15(18)6-4-11-21-16/h2-8,10-11,13,17,19H,9,12H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485796
PNG
((R)-N-methyl-3-(quinolin- 3-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@@H](Oc1cnc2ccccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-7-4-10-21-17)20-14-11-13-5-2-3-6-15(13)19-12-14/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485719
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(pyridin-3- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cccnc1
Show InChI InChI=1S/C18H19N3O/c1-19-10-8-17(15-5-3-9-20-13-15)22-18-6-2-4-14-12-21-11-7-16(14)18/h2-7,9,11-13,17,19H,8,10H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485723
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(pyridin-3- yl...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1cccnc1
Show InChI InChI=1S/C18H19N3O/c1-19-10-8-17(15-5-3-9-20-12-15)22-18-6-2-4-14-7-11-21-13-16(14)18/h2-7,9,11-13,17,19H,8,10H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485724
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(pyridin-2- yl...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccccn1
Show InChI InChI=1S/C18H19N3O/c1-19-11-9-18(16-6-2-3-10-21-16)22-17-7-4-5-14-8-12-20-13-15(14)17/h2-8,10,12-13,18-19H,9,11H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485728
PNG
(3-(5-chloropyridin-3-yl)-3- (isoquinolin-5-yloxy)-...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cncc(Cl)c1
Show InChI InChI=1S/C18H18ClN3O/c1-20-7-6-17(14-9-15(19)12-22-11-14)23-18-4-2-3-13-10-21-8-5-16(13)18/h2-5,8-12,17,20H,6-7H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485731
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(4- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-8-7-18(16-11-14(5-10-25-16)19(20,21)22)26-17-4-2-3-13-12-24-9-6-15(13)17/h2-6,9-12,18,23H,7-8H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485732
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(4- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-8-7-18(16-11-14(6-10-25-16)19(20,21)22)26-17-4-2-3-13-5-9-24-12-15(13)17/h2-6,9-12,18,23H,7-8H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485739
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(6- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-10-9-17(15-5-3-7-18(25-15)19(20,21)22)26-16-6-2-4-13-12-24-11-8-14(13)16/h2-8,11-12,17,23H,9-10H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485797
PNG
(()-N-methyl-3-(quinolin- 3-yloxy)-3-(thiophen-2- y...)
Show SMILES CNCC[C@H](Oc1cnc2ccccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-7-4-10-21-17)20-14-11-13-5-2-3-6-15(13)19-12-14/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485713
PNG
((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485727
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(pyridin-4- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccncc1
Show InChI InChI=1S/C18H19N3O/c1-19-9-8-17(14-5-10-20-11-6-14)22-18-4-2-3-15-13-21-12-7-16(15)18/h2-7,10-13,17,19H,8-9H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485746
PNG
(3-(isoquinolin-5-yloxy)-3- (thiophen-2-yl)propan-1...)
Show SMILES NCCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C16H16N2OS/c17-8-6-15(16-5-2-10-20-16)19-14-4-1-3-12-11-18-9-7-13(12)14/h1-5,7,9-11,15H,6,8,17H2
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485788
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485770
PNG
((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485771
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485709
PNG
(US10941138, Example 7)
Show SMILES CNCC[C@@H](Oc1ccc2ncccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-8-16(17-5-3-11-21-17)20-14-6-7-15-13(12-14)4-2-9-19-15/h2-7,9,11-12,16,18H,8,10H2,1H3/t16-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485710
PNG
(3-(isoquinolin-1-yloxy)- N,N-dimethyl-3-(thiophen-...)
Show SMILES CN(C)CCC(Oc1nccc2ccccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-20(2)12-10-16(17-8-5-13-22-17)21-18-15-7-4-3-6-14(15)9-11-19-18/h3-9,11,13,16H,10,12H2,1-2H3
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485726
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(6- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-10-9-17(15-5-3-7-18(25-15)19(20,21)22)26-16-6-2-4-13-8-11-24-12-14(13)16/h2-8,11-12,17,23H,9-10H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485729
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(pyridin-4- yl...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccncc1
Show InChI InChI=1S/C18H19N3O/c1-19-9-8-17(15-6-10-20-11-7-15)22-18-4-2-3-14-5-12-21-13-16(14)18/h2-7,10-13,17,19H,8-9H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485740
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(6- (trifluoromet...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-12-10-17(15-7-3-9-18(25-15)19(20,21)22)26-16-8-2-6-14-13(16)5-4-11-24-14/h2-9,11,17,23H,10,12H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485776
PNG
(3-(isoquinolin-7-yloxy)-N- methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1ccc2ccncc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-7-16(17-3-2-10-21-17)20-15-5-4-13-6-9-19-12-14(13)11-15/h2-6,9-12,16,18H,7-8H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485784
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-5-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485733
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(4- (trifluoromet...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-10-8-18(16-12-13(7-11-25-16)19(20,21)22)26-17-6-2-5-15-14(17)4-3-9-24-15/h2-7,9,11-12,18,23H,8,10H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485713
PNG
((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-12-19-10-7-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485742
PNG
(N-methyl-3-(quinolin-5- yloxy)-3-(6- (trifluoromet...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-11-9-16(13-7-8-18(25-12-13)19(20,21)22)26-17-6-2-5-15-14(17)4-3-10-24-15/h2-8,10,12,16,23H,9,11H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485692
PNG
(US10941138, Example 1)
Show SMILES CNCCC(Oc1cccc2cccnc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-14(16-8-4-12-21-16)20-15-7-2-5-13-6-3-10-19-17(13)15/h2-8,10,12,14,18H,9,11H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485712
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485719
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(pyridin-3- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1cccnc1
Show InChI InChI=1S/C18H19N3O/c1-19-10-8-17(15-5-3-9-20-13-15)22-18-6-2-4-14-12-21-11-7-16(14)18/h2-7,9,11-13,17,19H,8,10H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485720
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(tetrahydro-2H...)
Show SMILES CNCCC(Oc1cccc2cnccc12)C1CCOCC1
Show InChI InChI=1S/C18H24N2O2/c1-19-9-6-17(14-7-11-21-12-8-14)22-18-4-2-3-15-13-20-10-5-16(15)18/h2-5,10,13-14,17,19H,6-9,11-12H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485732
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(4- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-8-7-18(16-11-14(6-10-25-16)19(20,21)22)26-17-4-2-3-13-5-9-24-12-15(13)17/h2-6,9-12,18,23H,7-8H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485770
PNG
((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-11-19-9-5-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485784
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-5-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2cnccc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-11-20-9-5-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485706
PNG
(N-methyl-3-(quinolin-4- yloxy)-3-(thiophen-2- yl)p...)
Show SMILES CNCCC(Oc1ccnc2ccccc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-10-8-16(17-7-4-12-21-17)20-15-9-11-19-14-6-3-2-5-13(14)15/h2-7,9,11-12,16,18H,8,10H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485712
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-6-3-11-21-17)20-15-5-2-4-13-7-10-19-12-14(13)15/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485741
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(6- (trifluoro...)
Show SMILES CNCCC(Oc1cccc2ccncc12)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O/c1-23-9-8-16(14-5-6-18(25-11-14)19(20,21)22)26-17-4-2-3-13-7-10-24-12-15(13)17/h2-7,10-12,16,23H,8-9H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485794
PNG
((S)-N-ethyl-3-(isoquinolin- 5-yloxy)-3-(thiophen-2...)
Show SMILES CCNCC[C@H](Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-2-19-11-9-17(18-7-4-12-22-18)21-16-6-3-5-14-13-20-10-8-15(14)16/h3-8,10,12-13,17,19H,2,9,11H2,1H3/t17-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485771
PNG
((S)-3-(isoquinolin-8- yloxy)-N-methyl-3- (thiophen...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1ccsc1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-6-16(14-7-10-21-12-14)20-17-4-2-3-13-5-9-19-11-15(13)17/h2-5,7,9-12,16,18H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485788
PNG
((S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-8-ylo...)
Show SMILES CNCC[C@H](Oc1cccc2ccncc12)c1sccc1F
Show InChI InChI=1S/C17H17FN2OS/c1-19-8-6-16(17-14(18)7-10-22-17)21-15-4-2-3-12-5-9-20-11-13(12)15/h2-5,7,9-11,16,19H,6,8H2,1H3/t16-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485776
PNG
(3-(isoquinolin-7-yloxy)-N- methyl-3-(thiophen-2- y...)
Show SMILES CNCCC(Oc1ccc2ccncc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-8-7-16(17-3-2-10-21-17)20-15-5-4-13-6-9-19-12-14(13)11-15/h2-6,9-12,16,18H,7-8H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485692
PNG
(US10941138, Example 1)
Show SMILES CNCCC(Oc1cccc2cccnc12)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-11-9-14(16-8-4-12-21-16)20-15-7-2-5-13-6-3-10-19-17(13)15/h2-8,10,12,14,18H,9,11H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485735
PNG
(N-methyl-3-(pyridin-2-yl)- 3-(quinolin-5- yloxy)pr...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccccn1
Show InChI InChI=1S/C18H19N3O/c1-19-13-10-18(16-7-2-3-11-21-16)22-17-9-4-8-15-14(17)6-5-12-20-15/h2-9,11-12,18-19H,10,13H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485766
PNG
((S)-N-methyl-3-((1- methylisoquinolin-8- yl)oxy)-3...)
Show SMILES CNCC[C@H](Oc1cccc2ccnc(C)c12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-18-14(8-11-20-13)5-3-6-16(18)21-15(9-10-19-2)17-7-4-12-22-17/h3-8,11-12,15,19H,9-10H2,1-2H3/t15-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485767
PNG
((S)-N-methyl-3-((1- methylisoquinolin-5- yl)oxy)-3...)
Show SMILES CNCC[C@H](Oc1cccc2c(C)nccc12)c1cccs1
Show InChI InChI=1S/C18H20N2OS/c1-13-14-5-3-6-16(15(14)8-11-20-13)21-17(9-10-19-2)18-7-4-12-22-18/h3-8,11-12,17,19H,9-10H2,1-2H3/t17-/m0/s1
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485746
PNG
(3-(isoquinolin-5-yloxy)-3- (thiophen-2-yl)propan-1...)
Show SMILES NCCC(Oc1cccc2cnccc12)c1cccs1
Show InChI InChI=1S/C16H16N2OS/c17-8-6-15(16-5-2-10-20-16)19-14-4-1-3-12-11-18-9-7-13(12)14/h1-5,7,9-11,15H,6,8,17H2
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485708
PNG
(N-benzyl-3-(isoquinolin- 5-yloxy)-3-(thiophen-2- y...)
Show SMILES C(CC(Oc1cccc2cnccc12)c1cccs1)NCc1ccccc1
Show InChI InChI=1S/C23H22N2OS/c1-2-6-18(7-3-1)16-24-14-12-22(23-10-5-15-27-23)26-21-9-4-8-19-17-25-13-11-20(19)21/h1-11,13,15,17,22,24H,12,14,16H2
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485721
PNG
(3-(isoquinolin-8-yloxy)-N- methyl-3-(tetrahydro-2H...)
Show SMILES CNCCC(Oc1cccc2ccncc12)C1CCOCC1
Show InChI InChI=1S/C18H24N2O2/c1-19-9-6-17(15-7-11-21-12-8-15)22-18-4-2-3-14-5-10-20-13-16(14)18/h2-5,10,13,15,17,19H,6-9,11-12H2,1H3
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485725
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(pyridin-2- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccccn1
Show InChI InChI=1S/C18H19N3O/c1-19-11-9-18(16-6-2-3-10-21-16)22-17-7-4-5-14-13-20-12-8-15(14)17/h2-8,10,12-13,18-19H,9,11H2,1H3
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485727
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(pyridin-4- yl...)
Show SMILES CNCCC(Oc1cccc2cnccc12)c1ccncc1
Show InChI InChI=1S/C18H19N3O/c1-19-9-8-17(14-5-10-20-11-6-14)22-18-4-2-3-15-13-21-12-7-16(15)18/h2-7,10-13,17,19H,8-9H2,1H3
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485737
PNG
(N-methyl-3-(pyridin-4-yl)- 3-(quinolin-5- yloxy)pr...)
Show SMILES CNCCC(Oc1cccc2ncccc12)c1ccncc1
Show InChI InChI=1S/C18H19N3O/c1-19-11-9-17(14-7-12-20-13-8-14)22-18-6-2-5-16-15(18)4-3-10-21-16/h2-8,10,12-13,17,19H,9,11H2,1H3
PDB

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US Patent
>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485796
PNG
((R)-N-methyl-3-(quinolin- 3-yloxy)-3-(thiophen-2- ...)
Show SMILES CNCC[C@@H](Oc1cnc2ccccc2c1)c1cccs1
Show InChI InChI=1S/C17H18N2OS/c1-18-9-8-16(17-7-4-10-21-17)20-14-11-13-5-2-3-6-15(13)19-12-14/h2-7,10-12,16,18H,8-9H2,1H3/t16-/m1/s1
PDB

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>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel subunit alpha-2/delta-1


(Homo sapiens (Human))
BDBM485720
PNG
(3-(isoquinolin-5-yloxy)-N- methyl-3-(tetrahydro-2H...)
Show SMILES CNCCC(Oc1cccc2cnccc12)C1CCOCC1
Show InChI InChI=1S/C18H24N2O2/c1-19-9-6-17(14-7-11-21-12-8-14)22-18-4-2-3-15-13-20-10-5-16(15)18/h2-5,10,13-14,17,19H,6-9,11-12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
>3.00E+3n/an/an/an/an/an/an/an/a



ESTEVE PHARMACEUTICALS, S.A.

US Patent


Assay Description
Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...


US Patent US10941138 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%