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Patent code US10941162

Compile Data Set for Download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485799
PNG
(US10941162, Compound 103S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485809
PNG
(US10941162, Compound 181R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485802
PNG
(US10941162, Compound 175R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485809
PNG
(US10941162, Compound 181R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485810
PNG
(US10941162, Compound 181S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485800
PNG
(US10941162, Compound 103R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m1/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485800
PNG
(US10941162, Compound 103R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m1/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485799
PNG
(US10941162, Compound 103S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485799
PNG
(US10941162, Compound 103S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485816
PNG
(US10941162, Compound 341)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485810
PNG
(US10941162, Compound 181S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485801
PNG
(US10941162, Compound 175S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485800
PNG
(US10941162, Compound 103R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m1/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485798
PNG
(US10941162, Compound 103)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485809
PNG
(US10941162, Compound 181R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485810
PNG
(US10941162, Compound 181S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485816
PNG
(US10941162, Compound 341)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485798
PNG
(US10941162, Compound 103)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485801
PNG
(US10941162, Compound 175S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485801
PNG
(US10941162, Compound 175S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM485802
PNG
(US10941162, Compound 175R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485802
PNG
(US10941162, Compound 175R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM485816
PNG
(US10941162, Compound 341)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM485798
PNG
(US10941162, Compound 103)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485801
PNG
(US10941162, Compound 175S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485816
PNG
(US10941162, Compound 341)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485798
PNG
(US10941162, Compound 103)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485810
PNG
(US10941162, Compound 181S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485800
PNG
(US10941162, Compound 103R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485809
PNG
(US10941162, Compound 181R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#Cc3cnn(C)c3)c2cc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)26-28(31)36-38-15-7-14-32-29(26)38)27-24(21-8-4-3-5-9-21)16-23-22(10-6-11-25(23)35-27)13-12-20-17-33-37(2)18-20/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485799
PNG
(US10941162, Compound 103S)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1oc2cccc(C#Cc3cnn(C)c3)c2c(=O)c1-c1ccccc1
Show InChI InChI=1S/C30H23N7O3/c1-18(34-30(39)25-28(31)35-37-15-7-14-32-29(25)37)27-24(20-8-4-3-5-9-20)26(38)23-21(10-6-11-22(23)40-27)13-12-19-16-33-36(2)17-19/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,39)/t18-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM485802
PNG
(US10941162, Compound 175R)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2nc1-c1ccccc1
Show InChI InChI=1S/C30H24N8O/c1-19(34-30(39)25-28(31)36-38-15-7-14-32-29(25)38)24-16-23-11-6-10-22(13-12-20-17-33-37(2)18-20)26(23)35-27(24)21-8-4-3-5-9-21/h3-11,14-19H,1-2H3,(H2,31,36)(H,34,39)/t19-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation is used to screen compounds provided herein. This assay uses speci...


US Patent US10941162 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%