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Patent code US10947210

Compile Data Set for Download or QSAR
Found 164 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486076
PNG
(US10947210, Compound 06-7F)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3cccc(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O9S/c1-36-33(38)31-28-19-27(23-6-7-23)29(20-30(28)46-32(31)24-8-10-26(35)11-9-24)37(47(2,41)42)12-13-43-14-15-44-16-17-45-21-22-4-3-5-25(18-22)34(39)40/h3-5,8-11,18-20,23H,6-7,12-17,21H2,1-2H3,(H,36,38)(H,39,40)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486304
PNG
(US10947210, Compound 19-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccnc(Cl)c3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H31ClFN3O6S/c1-33-30(36)28-24-16-23(20-3-4-20)25(17-26(24)41-29(28)21-5-7-22(32)8-6-21)35(42(2,37)38)11-12-39-13-14-40-18-19-9-10-34-27(31)15-19/h5-10,15-17,20H,3-4,11-14,18H2,1-2H3,(H,33,36)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486194
PNG
(US10947210, Compound 11-6A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCc3ccccc3C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O8S/c1-35-32(37)30-27-19-26(22-7-8-22)28(20-29(27)44-31(30)23-9-11-24(34)12-10-23)36(45(2,40)41)14-16-43-18-17-42-15-13-21-5-3-4-6-25(21)33(38)39/h3-6,9-12,19-20,22H,7-8,13-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486200
PNG
(US10947210, Compound 11-6B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCc3cccc(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O8S/c1-35-32(37)30-27-19-26(22-6-7-22)28(20-29(27)44-31(30)23-8-10-25(34)11-9-23)36(45(2,40)41)13-15-43-17-16-42-14-12-21-4-3-5-24(18-21)33(38)39/h3-5,8-11,18-20,22H,6-7,12-17H2,1-2H3,(H,35,37)(H,38,39)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486303
PNG
(US10947210, Compound 18-10B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3C)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O8S/c1-20-16-23(33(38)39)6-7-24(20)19-43-15-14-42-13-12-36(45(3,40)41)28-18-29-27(17-26(28)21-4-5-21)30(32(37)35-2)31(44-29)22-8-10-25(34)11-9-22/h6-11,16-18,21H,4-5,12-15,19H2,1-3H3,(H,35,37)(H,38,39)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486321
PNG
(US10947210, Compound 26-7A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC3(CCCC3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H39FN2O9S/c1-34-30(36)28-25-19-24(21-5-6-21)26(20-27(25)44-29(28)22-7-9-23(33)10-8-22)35(45(2,39)40)13-14-41-15-16-42-17-18-43-32(31(37)38)11-3-4-12-32/h7-10,19-21H,3-6,11-18H2,1-2H3,(H,34,36)(H,37,38)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486329
PNG
(US10947210, Compound 28-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCOCCCCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H37FN2O7S/c1-32-30(36)28-24-18-23(20-9-10-20)25(19-26(24)40-29(28)21-11-13-22(31)14-12-21)33(41(2,37)38)15-5-3-6-16-39-17-7-4-8-27(34)35/h11-14,18-20H,3-10,15-17H2,1-2H3,(H,32,36)(H,34,35)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486330
PNG
(US10947210, Compound 28-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCOCCCC(C)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H39FN2O7S/c1-20(31(36)37)8-7-17-40-16-6-4-5-15-34(42(3,38)39)26-19-27-25(18-24(26)21-9-10-21)28(30(35)33-2)29(41-27)22-11-13-23(32)14-12-22/h11-14,18-21H,4-10,15-17H2,1-3H3,(H,33,35)(H,36,37)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486221
PNG
(US10947210, Compound 12-7A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCCc3ccccc3C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-36-33(38)31-28-20-27(23-9-10-23)29(21-30(28)45-32(31)24-11-13-25(35)14-12-24)37(46(2,41)42)15-17-44-19-18-43-16-5-7-22-6-3-4-8-26(22)34(39)40/h3-4,6,8,11-14,20-21,23H,5,7,9-10,15-19H2,1-2H3,(H,36,38)(H,39,40)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486222
PNG
(US10947210, Compound 12-7B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCCc3cccc(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-36-33(38)31-28-20-27(23-8-9-23)29(21-30(28)45-32(31)24-10-12-26(35)13-11-24)37(46(2,41)42)14-16-44-18-17-43-15-4-6-22-5-3-7-25(19-22)34(39)40/h3,5,7,10-13,19-21,23H,4,6,8-9,14-18H2,1-2H3,(H,36,38)(H,39,40)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486305
PNG
(US10947210, Compound 19-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(Cl)nc3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H31ClFN3O6S/c1-33-30(36)28-24-15-23(20-4-5-20)25(16-26(24)41-29(28)21-6-8-22(32)9-7-21)35(42(2,37)38)11-12-39-13-14-40-18-19-3-10-27(31)34-17-19/h3,6-10,15-17,20H,4-5,11-14,18H2,1-2H3,(H,33,36)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486277
PNG
(US10947210, Compound 14-7A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOc3ccccc3C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O9S/c1-35-32(37)30-26-19-25(21-7-8-21)27(20-29(26)45-31(30)22-9-11-23(34)12-10-22)36(46(2,40)41)13-14-42-15-16-43-17-18-44-28-6-4-3-5-24(28)33(38)39/h3-6,9-12,19-21H,7-8,13-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486307
PNG
(US10947210, Compound 20-8)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(C(O)=O)c4ccccc34)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H35FN2O8S/c1-38-35(40)33-30-19-29(22-7-8-22)31(20-32(30)47-34(33)23-9-12-25(37)13-10-23)39(48(2,43)44)15-16-45-17-18-46-21-24-11-14-28(36(41)42)27-6-4-3-5-26(24)27/h3-6,9-14,19-20,22H,7-8,15-18,21H2,1-2H3,(H,38,40)(H,41,42)
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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486308
PNG
(US10947210, Compound 21-5)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCSC(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H29FN2O6S2/c1-16(30)36-13-12-34-11-10-29(37(3,32)33)22-15-23-21(14-20(22)17-4-5-17)24(26(31)28-2)25(35-23)18-6-8-19(27)9-7-18/h6-9,14-15,17H,4-5,10-13H2,1-3H3,(H,28,31)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486299
PNG
(US10947210, Compound 17B-8)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(OC)c(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O9S/c1-35-32(37)30-25-17-24(21-5-6-21)27(18-29(25)45-31(30)22-7-9-23(34)10-8-22)36(46(3,40)41)12-13-43-14-15-44-19-20-4-11-28(42-2)26(16-20)33(38)39/h4,7-11,16-18,21H,5-6,12-15,19H2,1-3H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486333
PNG
(US10947210, Compound 29-9)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(C(=O)OC)c(N)c3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H36FN3O8S/c1-36-32(38)30-26-17-25(21-5-6-21)28(18-29(26)45-31(30)22-7-9-23(34)10-8-22)37(46(3,40)41)12-13-43-14-15-44-19-20-4-11-24(27(35)16-20)33(39)42-2/h4,7-11,16-18,21H,5-6,12-15,19,35H2,1-3H3,(H,36,38)
PDB

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US Patent
n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486315
PNG
(US10947210, Compound 24-4)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H35FN2O9S/c1-31-29(35)27-23-17-22(19-3-4-19)24(18-25(23)41-28(27)20-5-7-21(30)8-6-20)32(42(2,36)37)10-12-39-14-16-40-15-13-38-11-9-26(33)34/h5-8,17-19H,3-4,9-16H2,1-2H3,(H,31,35)(H,33,34)
PDB

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US Patent
n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486334
PNG
(US10947210, Compound 29-10)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(C(O)=O)c(N)c3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H34FN3O8S/c1-35-31(37)29-25-16-24(20-4-5-20)27(17-28(25)44-30(29)21-6-8-22(33)9-7-21)36(45(2,40)41)11-12-42-13-14-43-18-19-3-10-23(32(38)39)26(34)15-19/h3,6-10,15-17,20H,4-5,11-14,18,34H2,1-2H3,(H,35,37)(H,38,39)
PDB

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US Patent
n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486054
PNG
(US10947210, Compound 06-6A | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccccc3C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33FN2O8S/c1-34-31(36)29-26-17-25(20-7-8-20)27(18-28(26)43-30(29)21-9-11-23(33)12-10-21)35(44(2,39)40)13-14-41-15-16-42-19-22-5-3-4-6-24(22)32(37)38/h3-6,9-12,17-18,20H,7-8,13-16,19H2,1-2H3,(H,34,36)(H,37,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486054
PNG
(US10947210, Compound 06-6A | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccccc3C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33FN2O8S/c1-34-31(36)29-26-17-25(20-7-8-20)27(18-28(26)43-30(29)21-9-11-23(33)12-10-21)35(44(2,39)40)13-14-41-15-16-42-19-22-5-3-4-6-24(22)32(37)38/h3-6,9-12,17-18,20H,7-8,13-16,19H2,1-2H3,(H,34,36)(H,37,38)
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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486096
PNG
(US10947210, Compound 06-8B7)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(=O)OCc3ccccc3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H39FN2O8S/c1-41-38(43)36-33-22-32(28-12-13-28)34(23-35(33)50-37(36)29-14-16-31(40)17-15-29)42(51(2,45)46)18-19-47-20-21-48-24-27-8-10-30(11-9-27)39(44)49-25-26-6-4-3-5-7-26/h3-11,14-17,22-23,28H,12-13,18-21,24-25H2,1-2H3,(H,41,43)
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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486238
PNG
(US10947210, Compound 13-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCOCCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-35-32(37)30-27-19-26(22-10-11-22)28(20-29(27)43-31(30)23-12-14-25(34)15-13-23)36(44(2,40)41)16-4-18-42-17-3-5-21-6-8-24(9-7-21)33(38)39/h6-9,12-15,19-20,22H,3-5,10-11,16-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486246
PNG
(US10947210, Compound 14-6A)
Show SMILES CCOC(=O)c1ccccc1OCCOCCOCCN(c1cc2oc(c(C(=O)NC)c2cc1C1CC1)-c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C35H39FN2O9S/c1-4-45-35(40)26-7-5-6-8-30(26)46-20-19-44-18-17-43-16-15-38(48(3,41)42)29-22-31-28(21-27(29)23-9-10-23)32(34(39)37-2)33(47-31)24-11-13-25(36)14-12-24/h5-8,11-14,21-23H,4,9-10,15-20H2,1-3H3,(H,37,39)
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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486285
PNG
(US10947210, Compound 14-7C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O9S/c1-35-32(37)30-27-19-26(21-3-4-21)28(20-29(27)45-31(30)22-5-9-24(34)10-6-22)36(46(2,40)41)13-14-42-15-16-43-17-18-44-25-11-7-23(8-12-25)33(38)39/h5-12,19-21H,3-4,13-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486296
PNG
(US10947210, Compound 16-7)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCOCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-35-32(37)30-27-18-26(22-10-11-22)28(19-29(27)43-31(30)23-12-14-25(34)15-13-23)36(44(2,40)41)16-4-3-5-17-42-20-21-6-8-24(9-7-21)33(38)39/h6-9,12-15,18-19,22H,3-5,10-11,16-17,20H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486306
PNG
(US10947210, Compound 20-7)
Show SMILES CCOC(=O)c1ccc(COCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)c2ccccc12
Show InChI InChI=1S/C38H39FN2O8S/c1-4-48-38(43)30-16-13-26(28-7-5-6-8-29(28)30)23-47-20-19-46-18-17-41(50(3,44)45)33-22-34-32(21-31(33)24-9-10-24)35(37(42)40-2)36(49-34)25-11-14-27(39)15-12-25/h5-8,11-16,21-22,24H,4,9-10,17-20,23H2,1-3H3,(H,40,42)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486325
PNG
(US10947210, Compound 27-9A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCCCOCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H35FN2O8S/c1-31-29(35)27-23-16-22(19-6-7-19)24(17-25(23)40-28(27)20-8-10-21(30)11-9-20)32(41(2,36)37)12-15-38-13-4-3-5-14-39-18-26(33)34/h8-11,16-17,19H,3-7,12-15,18H2,1-2H3,(H,31,35)(H,33,34)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486088
PNG
(US10947210, Compound 06-8B3)
Show SMILES CCCCOC(=O)c1ccc(COCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C36H41FN2O8S/c1-4-5-17-46-36(41)27-8-6-24(7-9-27)23-45-20-19-44-18-16-39(48(3,42)43)31-22-32-30(21-29(31)25-10-11-25)33(35(40)38-2)34(47-32)26-12-14-28(37)15-13-26/h6-9,12-15,21-22,25H,4-5,10-11,16-20,23H2,1-3H3,(H,38,40)
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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486089
PNG
(US10947210, Compound 06-8B4)
Show SMILES CCCCCOC(=O)c1ccc(COCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C37H43FN2O8S/c1-4-5-6-18-47-37(42)28-9-7-25(8-10-28)24-46-21-20-45-19-17-40(49(3,43)44)32-23-33-31(22-30(32)26-11-12-26)34(36(41)39-2)35(48-33)27-13-15-29(38)16-14-27/h7-10,13-16,22-23,26H,4-6,11-12,17-21,24H2,1-3H3,(H,39,41)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486090
PNG
(US10947210, Compound 06-8B5)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(=O)OCC(N)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H36FN3O9S/c1-37-33(40)31-27-17-26(22-7-8-22)28(18-29(27)47-32(31)23-9-11-25(35)12-10-23)38(48(2,42)43)13-14-44-15-16-45-19-21-3-5-24(6-4-21)34(41)46-20-30(36)39/h3-6,9-12,17-18,22H,7-8,13-16,19-20H2,1-2H3,(H2,36,39)(H,37,40)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486239
PNG
(US10947210, Compound 13-8C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCOCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-35-32(37)30-27-19-26(22-9-10-22)28(20-29(27)43-31(30)23-11-13-25(34)14-12-23)36(44(2,40)41)16-3-4-17-42-18-15-21-5-7-24(8-6-21)33(38)39/h5-8,11-14,19-20,22H,3-4,9-10,15-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486297
PNG
(US10947210, Compound 17A-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(F)c(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H32F2N2O8S/c1-35-31(37)29-25-16-23(20-4-5-20)27(17-28(25)44-30(29)21-6-8-22(33)9-7-21)36(45(2,40)41)11-12-42-13-14-43-18-19-3-10-26(34)24(15-19)32(38)39/h3,6-10,15-17,20H,4-5,11-14,18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486317
PNG
(US10947210, Compound 25-5)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C(O)=O)c3ccccc3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O9S/c1-36-33(38)30-27-20-26(22-8-9-22)28(21-29(27)46-31(30)24-10-12-25(35)13-11-24)37(47(2,41)42)14-15-43-16-17-44-18-19-45-32(34(39)40)23-6-4-3-5-7-23/h3-7,10-13,20-22,32H,8-9,14-19H2,1-2H3,(H,36,38)(H,39,40)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486068
PNG
(US10947210, Compound 06-7C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3cccc(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33FN2O8S/c1-34-31(36)29-26-17-25(21-6-7-21)27(18-28(26)43-30(29)22-8-10-24(33)11-9-22)35(44(2,39)40)12-13-41-14-15-42-19-20-4-3-5-23(16-20)32(37)38/h3-5,8-11,16-18,21H,6-7,12-15,19H2,1-2H3,(H,34,36)(H,37,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486102
PNG
(US10947210, Compound 08-6)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOC(=O)CNC(=O)CCCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H32FN3O9S/c1-31-29(38)27-21-14-20(17-6-7-17)22(15-23(21)42-28(27)18-8-10-19(30)11-9-18)33(43(2,39)40)12-13-41-26(37)16-32-24(34)4-3-5-25(35)36/h8-11,14-15,17H,3-7,12-13,16H2,1-2H3,(H,31,38)(H,32,34)(H,35,36)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486103
PNG
(US10947210, Compound 09-14A)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NCC(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H33FN4O10S/c1-37-34(45)32-25-13-24(20-6-7-20)26(14-29(25)50-33(32)21-8-10-23(36)11-9-21)40(51(2,48)49)18-31(44)39-17-30(43)38-16-19-4-3-5-22(12-19)27(41)15-28(42)35(46)47/h3-5,8-15,20,42H,6-7,16-18H2,1-2H3,(H,37,45)(H,38,43)(H,39,44)(H,46,47)/b28-15-
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486223
PNG
(US10947210, Compound 12-7C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-36-33(38)31-28-20-27(23-9-10-23)29(21-30(28)45-32(31)24-11-13-26(35)14-12-24)37(46(2,41)42)15-17-44-19-18-43-16-3-4-22-5-7-25(8-6-22)34(39)40/h5-8,11-14,20-21,23H,3-4,9-10,15-19H2,1-2H3,(H,36,38)(H,39,40)
PDB

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US Patent
n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486233
PNG
(US10947210, Compound 13-7D)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCCCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H39FN2O6S/c1-37-34(39)32-29-21-28(24-14-15-24)30(22-31(29)44-33(32)25-16-18-27(36)19-17-25)38(45(3,41)42)20-8-6-4-5-7-9-23-10-12-26(13-11-23)35(40)43-2/h10-13,16-19,21-22,24H,4-9,14-15,20H2,1-3H3,(H,37,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486282
PNG
(US10947210, Compound 14-7B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOc3cccc(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O9S/c1-35-32(37)30-27-19-26(21-6-7-21)28(20-29(27)45-31(30)22-8-10-24(34)11-9-22)36(46(2,40)41)12-13-42-14-15-43-16-17-44-25-5-3-4-23(18-25)33(38)39/h3-5,8-11,18-21H,6-7,12-17H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486322
PNG
(US10947210, Compound 26-7B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C)(C)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H37FN2O9S/c1-30(2,29(35)36)41-16-15-40-14-13-39-12-11-33(43(4,37)38)24-18-25-23(17-22(24)19-5-6-19)26(28(34)32-3)27(42-25)20-7-9-21(31)10-8-20/h7-10,17-19H,5-6,11-16H2,1-4H3,(H,32,34)(H,35,36)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486060
PNG
(US10947210, Compound 06-6D)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3ccccc3C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H39FN2O9S/c1-37-34(39)32-29-20-28(23-8-9-23)30(21-31(29)47-33(32)24-10-12-26(36)13-11-24)38(48(3,41)42)14-15-44-16-17-45-18-19-46-22-25-6-4-5-7-27(25)35(40)43-2/h4-7,10-13,20-21,23H,8-9,14-19,22H2,1-3H3,(H,37,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486075
PNG
(US10947210, Compound 06-7E | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O9S/c1-36-33(38)31-28-19-27(23-7-8-23)29(20-30(28)46-32(31)24-9-11-26(35)12-10-24)37(47(2,41)42)13-14-43-15-16-44-17-18-45-21-22-3-5-25(6-4-22)34(39)40/h3-6,9-12,19-20,23H,7-8,13-18,21H2,1-2H3,(H,36,38)(H,39,40)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486098
PNG
(US10947210, Compound 06-8B8)
Show SMILES CCOC(=O)COC(=O)c1ccc(COCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C36H39FN2O10S/c1-4-47-32(40)22-48-36(42)26-7-5-23(6-8-26)21-46-18-17-45-16-15-39(50(3,43)44)30-20-31-29(19-28(30)24-9-10-24)33(35(41)38-2)34(49-31)25-11-13-27(37)14-12-25/h5-8,11-14,19-20,24H,4,9-10,15-18,21-22H2,1-3H3,(H,38,41)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486224
PNG
(US10947210, Compound 13-7A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O7S/c1-36-33(38)31-28-20-27(23-11-12-23)29(21-30(28)44-32(31)24-13-15-26(35)16-14-24)37(45(3,40)41)17-19-43-18-5-4-6-22-7-9-25(10-8-22)34(39)42-2/h7-10,13-16,20-21,23H,4-6,11-12,17-19H2,1-3H3,(H,36,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486286
PNG
(US10947210, Compound 15-7)
Show SMILES CCOC(=O)c1ccc(OCCCCCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C35H39FN2O7S/c1-4-43-35(40)25-13-17-27(18-14-25)44-20-8-6-5-7-19-38(46(3,41)42)30-22-31-29(21-28(30)23-9-10-23)32(34(39)37-2)33(45-31)24-11-15-26(36)16-12-24/h11-18,21-23H,4-10,19-20H2,1-3H3,(H,37,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486314
PNG
(US10947210, Compound 23-7A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCC(N)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H34FN3O8S/c1-31-28(34)26-22-15-21(18-3-4-18)23(16-24(22)40-27(26)19-5-7-20(29)8-6-19)32(41(2,35)36)9-10-37-11-12-38-13-14-39-17-25(30)33/h5-8,15-16,18H,3-4,9-14,17H2,1-2H3,(H2,30,33)(H,31,34)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486327
PNG
(US10947210, Compound 27-9B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCCCOC(C)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H37FN2O8S/c1-19(30(35)36)40-15-6-4-5-14-39-16-13-33(42(3,37)38)25-18-26-24(17-23(25)20-7-8-20)27(29(34)32-2)28(41-26)21-9-11-22(31)12-10-21/h9-12,17-20H,4-8,13-16H2,1-3H3,(H,32,34)(H,35,36)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486332
PNG
(US10947210, Compound 29-8)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(C(O)=O)c(c3)[N+]([O-])=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H32FN3O10S/c1-34-31(37)29-25-16-24(20-4-5-20)26(17-28(25)46-30(29)21-6-8-22(33)9-7-21)35(47(2,42)43)11-12-44-13-14-45-18-19-3-10-23(32(38)39)27(15-19)36(40)41/h3,6-10,15-17,20H,4-5,11-14,18H2,1-2H3,(H,34,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485959
PNG
(US10947210, Compound 02-10A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H35FN2O10S/c1-37-34(41)32-27-17-26(22-6-7-22)28(18-31(27)48-33(32)23-8-10-25(36)11-9-23)38(49(2,44)45)12-13-46-14-15-47-20-21-4-3-5-24(16-21)29(39)19-30(40)35(42)43/h3-5,8-11,16-19,22,40H,6-7,12-15,20H2,1-2H3,(H,37,41)(H,42,43)/b30-19-
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485967
PNG
(US10947210, Compound 02-10C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H43FN2O12S/c1-41-38(45)36-31-21-30(26-6-7-26)32(22-35(31)54-37(36)27-8-10-29(40)11-9-27)42(55(2,48)49)12-13-50-14-15-51-16-17-52-18-19-53-24-25-4-3-5-28(20-25)33(43)23-34(44)39(46)47/h3-5,8-11,20-23,26,44H,6-7,12-19,24H2,1-2H3,(H,41,45)(H,46,47)/b34-23-
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486062
PNG
(US10947210, Compound 06-6E)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H39FN2O9S/c1-37-34(39)32-29-20-28(24-8-9-24)30(21-31(29)47-33(32)25-10-12-27(36)13-11-25)38(48(3,41)42)14-15-44-16-17-45-18-19-46-22-23-4-6-26(7-5-23)35(40)43-2/h4-7,10-13,20-21,24H,8-9,14-19,22H2,1-3H3,(H,37,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486067
PNG
(US10947210, Compound 06-7B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33FN2O8S/c1-34-31(36)29-26-17-25(21-7-8-21)27(18-28(26)43-30(29)22-9-11-24(33)12-10-22)35(44(2,39)40)13-14-41-15-16-42-19-20-3-5-23(6-4-20)32(37)38/h3-6,9-12,17-18,21H,7-8,13-16,19H2,1-2H3,(H,34,36)(H,37,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486072
PNG
(US10947210, Compound 06-7D)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3ccccc3C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O9S/c1-36-33(38)31-28-19-27(22-7-8-22)29(20-30(28)46-32(31)23-9-11-25(35)12-10-23)37(47(2,41)42)13-14-43-15-16-44-17-18-45-21-24-5-3-4-6-26(24)34(39)40/h3-6,9-12,19-20,22H,7-8,13-18,21H2,1-2H3,(H,36,38)(H,39,40)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486191
PNG
(US10947210, Compound 11-5A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCc3ccccc3C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-36-33(38)31-28-20-27(23-8-9-23)29(21-30(28)45-32(31)24-10-12-25(35)13-11-24)37(46(3,40)41)15-17-44-19-18-43-16-14-22-6-4-5-7-26(22)34(39)42-2/h4-7,10-13,20-21,23H,8-9,14-19H2,1-3H3,(H,36,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486225
PNG
(US10947210, Compound 13-7B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCOCCCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O7S/c1-36-33(38)31-28-20-27(23-11-12-23)29(21-30(28)44-32(31)24-13-15-26(35)16-14-24)37(45(3,40)41)17-5-19-43-18-4-6-22-7-9-25(10-8-22)34(39)42-2/h7-10,13-16,20-21,23H,4-6,11-12,17-19H2,1-3H3,(H,36,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486294
PNG
(US10947210, Compound 15-8)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCCOc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-35-32(37)30-27-19-26(21-7-8-21)28(20-29(27)43-31(30)22-9-13-24(34)14-10-22)36(44(2,40)41)17-5-3-4-6-18-42-25-15-11-23(12-16-25)33(38)39/h9-16,19-21H,3-8,17-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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US Patent
n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486302
PNG
(US10947210, Compound 18-10A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(C(O)=O)c(C)c3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O8S/c1-20-16-21(4-11-25(20)33(38)39)19-43-15-14-42-13-12-36(45(3,40)41)28-18-29-27(17-26(28)22-5-6-22)30(32(37)35-2)31(44-29)23-7-9-24(34)10-8-23/h4,7-11,16-18,22H,5-6,12-15,19H2,1-3H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486331
PNG
(US10947210, Compound 29-7)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(C(=O)OC)c(c3)[N+]([O-])=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H34FN3O10S/c1-35-32(38)30-26-17-25(21-5-6-21)27(18-29(26)47-31(30)22-7-9-23(34)10-8-22)36(48(3,42)43)12-13-45-14-15-46-19-20-4-11-24(33(39)44-2)28(16-20)37(40)41/h4,7-11,16-18,21H,5-6,12-15,19H2,1-3H3,(H,35,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486091
PNG
(US10947210, Compound 06-8B6)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(=O)OCSC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S2/c1-36-33(38)31-28-18-27(23-8-9-23)29(19-30(28)45-32(31)24-10-12-26(35)13-11-24)37(47(3,40)41)14-15-42-16-17-43-20-22-4-6-25(7-5-22)34(39)44-21-46-2/h4-7,10-13,18-19,23H,8-9,14-17,20-21H2,1-3H3,(H,36,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486231
PNG
(US10947210, Compound 13-7C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCOCCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O7S/c1-36-33(38)31-28-20-27(23-10-11-23)29(21-30(28)44-32(31)24-12-14-26(35)15-13-24)37(45(3,40)41)17-4-5-18-43-19-16-22-6-8-25(9-7-22)34(39)42-2/h6-9,12-15,20-21,23H,4-5,10-11,16-19H2,1-3H3,(H,36,38)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486235
PNG
(US10947210, Compound 13-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-35-32(37)30-27-19-26(22-10-11-22)28(20-29(27)43-31(30)23-12-14-25(34)15-13-23)36(44(2,40)41)16-18-42-17-4-3-5-21-6-8-24(9-7-21)33(38)39/h6-9,12-15,19-20,22H,3-5,10-11,16-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486241
PNG
(US10947210, Compound 13-8D)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O6S/c1-36-33(38)31-28-20-27(23-13-14-23)29(21-30(28)43-32(31)24-15-17-26(35)18-16-24)37(44(2,41)42)19-7-5-3-4-6-8-22-9-11-25(12-10-22)34(39)40/h9-12,15-18,20-21,23H,3-8,13-14,19H2,1-2H3,(H,36,38)(H,39,40)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486312
PNG
(US10947210, Compound 23-6B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H35FN2O9S/c1-18(29(34)35)40-15-14-39-13-12-38-11-10-32(42(3,36)37)24-17-25-23(16-22(24)19-4-5-19)26(28(33)31-2)27(41-25)20-6-8-21(30)9-7-20/h6-9,16-19H,4-5,10-15H2,1-3H3,(H,31,33)(H,34,35)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486035
PNG
(US10947210, Compound 03-8A)
Show SMILES CCOC(=O)C(\O)=C\C(=O)c1cccc(COCCOCCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C38H41FN2O10S/c1-4-50-38(45)33(43)22-32(42)27-8-5-7-24(19-27)23-49-18-17-48-16-6-15-41(52(3,46)47)31-21-34-30(20-29(31)25-9-10-25)35(37(44)40-2)36(51-34)26-11-13-28(39)14-12-26/h5,7-8,11-14,19-22,25,43H,4,6,9-10,15-18,23H2,1-3H3,(H,40,44)/b33-22-
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486214
PNG
(US10947210, Compound 11-6C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O8S/c1-35-32(37)30-27-19-26(22-7-8-22)28(20-29(27)44-31(30)23-9-11-25(34)12-10-23)36(45(2,40)41)14-16-43-18-17-42-15-13-21-3-5-24(6-4-21)33(38)39/h3-6,9-12,19-20,22H,7-8,13-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486220
PNG
(US10947210, Compound 12-6A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCCc3ccccc3C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H39FN2O8S/c1-37-34(39)32-29-21-28(24-10-11-24)30(22-31(29)46-33(32)25-12-14-26(36)15-13-25)38(47(3,41)42)16-18-45-20-19-44-17-6-8-23-7-4-5-9-27(23)35(40)43-2/h4-5,7,9,12-15,21-22,24H,6,8,10-11,16-20H2,1-3H3,(H,37,39)
PDB

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US Patent
n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486311
PNG
(US10947210, Compound 23-6A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H33FN2O9S/c1-30-28(34)26-22-15-21(18-3-4-18)23(16-24(22)40-27(26)19-5-7-20(29)8-6-19)31(41(2,35)36)9-10-37-11-12-38-13-14-39-17-25(32)33/h5-8,15-16,18H,3-4,9-14,17H2,1-2H3,(H,30,34)(H,32,33)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486313
PNG
(US10947210, Compound 23-6C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCC(=O)NO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H34FN3O9S/c1-30-28(34)26-22-15-21(18-3-4-18)23(16-24(22)41-27(26)19-5-7-20(29)8-6-19)32(42(2,36)37)9-10-38-11-12-39-13-14-40-17-25(33)31-35/h5-8,15-16,18,35H,3-4,9-14,17H2,1-2H3,(H,30,34)(H,31,33)
PDB

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n/an/a 550n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485969
PNG
(US10947210, Compound 02-10F)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H35FN2O10S/c1-37-34(41)32-27-17-26(22-7-8-22)28(18-31(27)48-33(32)24-9-11-25(36)12-10-24)38(49(2,44)45)13-14-46-15-16-47-20-21-3-5-23(6-4-21)29(39)19-30(40)35(42)43/h3-6,9-12,17-19,22,40H,7-8,13-16,20H2,1-2H3,(H,37,41)(H,42,43)/b30-19-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486040
PNG
(US10947210, Compound 04-10 | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H35FN2O8S/c1-30-28(33)26-23-17-22(19-3-4-19)24(18-25(23)39-27(26)20-5-7-21(29)8-6-20)31(40(2,34)35)9-11-36-13-15-38-16-14-37-12-10-32/h5-8,17-19,32H,3-4,9-16H2,1-2H3,(H,30,33)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486052
PNG
(US10947210, Compound 05-4B)
Show SMILES CCCCOCCOCCOCCN(c1cc2oc(c(C(=O)NC)c2cc1C1CC1)-c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C30H39FN2O7S/c1-4-5-13-37-15-17-39-18-16-38-14-12-33(41(3,35)36)26-20-27-25(19-24(26)21-6-7-21)28(30(34)32-2)29(40-27)22-8-10-23(31)11-9-22/h8-11,19-21H,4-7,12-18H2,1-3H3,(H,32,34)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486147
PNG
(US10947210, Compound 09-14E)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NC3(CCCC3)C(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H39FN4O10S/c1-41-36(48)34-28-17-27(23-8-9-23)29(18-32(28)54-35(34)24-10-12-26(40)13-11-24)44(55(2,52)53)21-33(47)43-39(14-3-4-15-39)38(51)42-20-22-6-5-7-25(16-22)30(45)19-31(46)37(49)50/h5-7,10-13,16-19,23,46H,3-4,8-9,14-15,20-21H2,1-2H3,(H,41,48)(H,42,51)(H,43,47)(H,49,50)/b31-19-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486149
PNG
(US10947210, Compound 09-14F)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NC(C)C(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H35FN4O10S/c1-19(34(45)39-17-20-5-4-6-23(13-20)28(42)16-29(43)36(47)48)40-31(44)18-41(52(3,49)50)27-15-30-26(14-25(27)21-7-8-21)32(35(46)38-2)33(51-30)22-9-11-24(37)12-10-22/h4-6,9-16,19,21,43H,7-8,17-18H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)(H,47,48)/b29-16-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486192
PNG
(US10947210, Compound 11-5B)
Show SMILES CCOC(=O)c1cccc(CCOCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C35H39FN2O8S/c1-4-45-35(40)26-7-5-6-23(20-26)14-16-43-18-19-44-17-15-38(47(3,41)42)30-22-31-29(21-28(30)24-8-9-24)32(34(39)37-2)33(46-31)25-10-12-27(36)13-11-25/h5-7,10-13,20-22,24H,4,8-9,14-19H2,1-3H3,(H,37,39)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486262
PNG
(US10947210, Compound 14-6C)
Show SMILES CCOC(=O)c1ccc(OCCOCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C35H39FN2O9S/c1-4-45-35(40)25-9-13-27(14-10-25)46-20-19-44-18-17-43-16-15-38(48(3,41)42)30-22-31-29(21-28(30)23-5-6-23)32(34(39)37-2)33(47-31)24-7-11-26(36)12-8-24/h7-14,21-23H,4-6,15-20H2,1-3H3,(H,37,39)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486301
PNG
(US10947210, Compound 18-9B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3C)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-21-17-24(34(39)42-3)7-8-25(21)20-44-16-15-43-14-13-37(46(4,40)41)29-19-30-28(18-27(29)22-5-6-22)31(33(38)36-2)32(45-30)23-9-11-26(35)12-10-23/h7-12,17-19,22H,5-6,13-16,20H2,1-4H3,(H,36,38)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486338
PNG
(US10947210, Compound 30-4)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCc3cccc(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H41FN2O10S/c1-38-35(40)33-30-21-29(25-6-7-25)31(22-32(30)49-34(33)26-8-10-28(37)11-9-26)39(50(2,43)44)12-13-45-14-15-46-16-17-47-18-19-48-23-24-4-3-5-27(20-24)36(41)42/h3-5,8-11,20-22,25H,6-7,12-19,23H2,1-2H3,(H,38,40)(H,41,42)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486340
PNG
(US10947210, Compound 30-6)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NCC(=O)NCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H33FN4O7S/c1-19(39)23-6-4-5-20(13-23)16-36-29(40)17-37-30(41)18-38(46(3,43)44)27-15-28-26(14-25(27)21-7-8-21)31(33(42)35-2)32(45-28)22-9-11-24(34)12-10-22/h4-6,9-15,21H,7-8,16-18H2,1-3H3,(H,35,42)(H,36,40)(H,37,41)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486012
PNG
(US10947210, Compound 03-6A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCOCCOCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O7S/c1-22(38)26-7-4-6-23(18-26)21-43-17-16-42-15-5-14-37(45(3,40)41)30-20-31-29(19-28(30)24-8-9-24)32(34(39)36-2)33(44-31)25-10-12-27(35)13-11-25/h4,6-7,10-13,18-20,24H,5,8-9,14-17,21H2,1-3H3,(H,36,39)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486063
PNG
(US10947210, Compound 06-6F)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3cccc(c3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H39FN2O9S/c1-37-34(39)32-29-20-28(24-7-8-24)30(21-31(29)47-33(32)25-9-11-27(36)12-10-25)38(48(3,41)42)13-14-44-15-16-45-17-18-46-22-23-5-4-6-26(19-23)35(40)43-2/h4-6,9-12,19-21,24H,7-8,13-18,22H2,1-3H3,(H,37,39)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486151
PNG
(US10947210, Compound 10-3B)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NCC(=O)NCCCC(C)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H37FN4O8S/c1-18(31(40)43-3)6-5-13-34-26(37)16-35-27(38)17-36(45(4,41)42)24-15-25-23(14-22(24)19-7-8-19)28(30(39)33-2)29(44-25)20-9-11-21(32)12-10-20/h9-12,14-15,18-19H,5-8,13,16-17H2,1-4H3,(H,33,39)(H,34,37)(H,35,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486318
PNG
(US10947210, Compound 25-6)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C(=O)NO)c3ccccc3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H38FN3O9S/c1-36-33(39)30-27-20-26(22-8-9-22)28(21-29(27)47-31(30)24-10-12-25(35)13-11-24)38(48(2,42)43)14-15-44-16-17-45-18-19-46-32(34(40)37-41)23-6-4-3-5-7-23/h3-7,10-13,20-22,32,41H,8-9,14-19H2,1-2H3,(H,36,39)(H,37,40)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486337
PNG
(US10947210, Compound 30-3)
Show SMILES CCOC(=O)CCOCCOCCOCCN(c1cc2oc(c(C(=O)NC)c2cc1C1CC1)-c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H39FN2O9S/c1-4-42-28(35)11-13-39-15-17-41-18-16-40-14-12-34(44(3,37)38)26-20-27-25(19-24(26)21-5-6-21)29(31(36)33-2)30(43-27)22-7-9-23(32)10-8-22/h7-10,19-21H,4-6,11-18H2,1-3H3,(H,33,36)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486346
PNG
(US10947210, Compound 30-11)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(OC)c(c3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O9S/c1-36-33(38)31-26-18-25(22-6-7-22)28(19-30(26)46-32(31)23-8-10-24(35)11-9-23)37(47(4,40)41)13-14-44-15-16-45-20-21-5-12-29(42-2)27(17-21)34(39)43-3/h5,8-12,17-19,22H,6-7,13-16,20H2,1-4H3,(H,36,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485980
PNG
(US10947210, Compound 02-10I)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCc3ccc(cc3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C41H47FN2O13S/c1-43-40(47)38-33-23-32(28-7-8-28)34(24-37(33)57-39(38)30-9-11-31(42)12-10-30)44(58(2,50)51)13-14-52-15-16-53-17-18-54-19-20-55-21-22-56-26-27-3-5-29(6-4-27)35(45)25-36(46)41(48)49/h3-6,9-12,23-25,28,46H,7-8,13-22,26H2,1-2H3,(H,43,47)(H,48,49)/b36-25-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485981
PNG
(US10947210, Compound 02-10J)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCCOCc3ccc(cc3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C43H51FN2O14S/c1-45-42(49)40-35-25-34(30-7-8-30)36(26-39(35)60-41(40)32-9-11-33(44)12-10-32)46(61(2,52)53)13-14-54-15-16-55-17-18-56-19-20-57-21-22-58-23-24-59-28-29-3-5-31(6-4-29)37(47)27-38(48)43(50)51/h3-6,9-12,25-27,30,48H,7-8,13-24,28H2,1-2H3,(H,45,49)(H,50,51)/b38-27-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485985
PNG
(US10947210, Compound 02-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H39FN2O8S/c1-23(39)27-6-4-5-24(19-27)22-45-18-17-44-16-15-43-14-13-38(47(3,41)42)31-21-32-30(20-29(31)25-7-8-25)33(35(40)37-2)34(46-32)26-9-11-28(36)12-10-26/h4-6,9-12,19-21,25H,7-8,13-18,22H2,1-3H3,(H,37,40)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486048
PNG
(US10947210, Compound 05-4A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H37FN2O8S/c1-31-29(33)27-24-18-23(20-4-5-20)25(19-26(24)40-28(27)21-6-8-22(30)9-7-21)32(41(3,34)35)10-11-37-14-15-39-17-16-38-13-12-36-2/h6-9,18-20H,4-5,10-17H2,1-3H3,(H,31,33)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486105
PNG
(US10947210, Compound 09-14C)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NC(C)(C)C(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H37FN4O10S/c1-37(2,36(49)40-18-20-6-5-7-23(14-20)28(43)17-29(44)35(47)48)41-31(45)19-42(53(4,50)51)27-16-30-26(15-25(27)21-8-9-21)32(34(46)39-3)33(52-30)22-10-12-24(38)13-11-22/h5-7,10-17,21,44H,8-9,18-19H2,1-4H3,(H,39,46)(H,40,49)(H,41,45)(H,47,48)/b29-17-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486309
PNG
(US10947210, Compound 22-12)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H35FN2O9S/c1-37-34(41)32-27-18-26(22-8-9-22)28(19-31(27)47-33(32)23-10-12-25(36)13-11-23)38(48(2,44)45)14-16-46-15-4-6-21-5-3-7-24(17-21)29(39)20-30(40)35(42)43/h3,5,7,10-13,17-20,22,40H,4,6,8-9,14-16H2,1-2H3,(H,37,41)(H,42,43)/b30-20-
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486328
PNG
(US10947210, Compound 28-7A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCOCCCCC(=O)OC(C)(C)C)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H45FN2O7S/c1-34(2,3)44-30(38)11-7-10-20-42-19-9-6-8-18-37(45(5,40)41)28-22-29-27(21-26(28)23-12-13-23)31(33(39)36-4)32(43-29)24-14-16-25(35)17-15-24/h14-17,21-23H,6-13,18-20H2,1-5H3,(H,36,39)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486348
PNG
(US10947210, Compound 30-13)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCCOCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C40H49FN2O12S/c1-42-39(44)37-34-25-33(29-7-8-29)35(26-36(34)55-38(37)30-9-11-32(41)12-10-30)43(56(2,47)48)13-14-49-15-16-50-17-18-51-19-20-52-21-22-53-23-24-54-27-28-3-5-31(6-4-28)40(45)46/h3-6,9-12,25-26,29H,7-8,13-24,27H2,1-2H3,(H,42,44)(H,45,46)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486350
PNG
(US10947210, Compound 30-15)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCCCCc3cccc(c3)C(=O)CC(=O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C41H47FN2O11S/c1-43-40(47)38-33-24-32(28-10-11-28)34(25-37(33)55-39(38)29-12-14-31(42)15-13-29)44(56(2,50)51)16-18-53-20-22-54-21-19-52-17-5-3-4-7-27-8-6-9-30(23-27)35(45)26-36(46)41(48)49/h6,8-9,12-15,23-25,28H,3-5,7,10-11,16-22,26H2,1-2H3,(H,43,47)(H,48,49)
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485987
PNG
(US10947210, Compound 02-8E)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCCOCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C41H51FN2O11S/c1-29(45)33-6-4-5-30(25-33)28-54-24-23-53-22-21-52-20-19-51-18-17-50-16-15-49-14-13-44(56(3,47)48)37-27-38-36(26-35(37)31-7-8-31)39(41(46)43-2)40(55-38)32-9-11-34(42)12-10-32/h4-6,9-12,25-27,31H,7-8,13-24,28H2,1-3H3,(H,43,46)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486004
PNG
(US10947210, Compound 02-9C)
Show SMILES CCOC(=O)C(\O)=C\C(=O)c1cccc(COCCOCCOCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C41H47FN2O12S/c1-4-55-41(48)36(46)25-35(45)30-7-5-6-27(22-30)26-54-21-20-53-19-18-52-17-16-51-15-14-44(57(3,49)50)34-24-37-33(23-32(34)28-8-9-28)38(40(47)43-2)39(56-37)29-10-12-31(42)13-11-29/h5-7,10-13,22-25,28,46H,4,8-9,14-21,26H2,1-3H3,(H,43,47)/b36-25-
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486150
PNG
(US10947210, Compound 10-3A | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NCC(=O)NCCCCC(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O8S/c1-32-30(39)28-22-14-21(18-7-8-18)23(15-24(22)43-29(28)19-9-11-20(31)12-10-19)35(44(3,40)41)17-26(37)34-16-25(36)33-13-5-4-6-27(38)42-2/h9-12,14-15,18H,4-8,13,16-17H2,1-3H3,(H,32,39)(H,33,36)(H,34,37)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486310
PNG
(US10947210, Compound 23-5A)
Show SMILES CCCCOC(=O)COCCOCCOCCN(c1cc2oc(c(C(=O)NC)c2cc1C1CC1)-c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C32H41FN2O9S/c1-4-5-13-43-29(36)21-42-18-17-41-16-15-40-14-12-35(45(3,38)39)27-20-28-26(19-25(27)22-6-7-22)30(32(37)34-2)31(44-28)23-8-10-24(33)11-9-23/h8-11,19-20,22H,4-7,12-18,21H2,1-3H3,(H,34,37)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485963
PNG
(US10947210, Compound 02-10B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H39FN2O11S/c1-39-36(43)34-29-19-28(24-6-7-24)30(20-33(29)51-35(34)25-8-10-27(38)11-9-25)40(52(2,46)47)12-13-48-14-15-49-16-17-50-22-23-4-3-5-26(18-23)31(41)21-32(42)37(44)45/h3-5,8-11,18-21,24,42H,6-7,12-17,22H2,1-2H3,(H,39,43)(H,44,45)/b32-21-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485968
PNG
(US10947210, Compound 02-10E)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C43H51FN2O14S/c1-45-42(49)40-35-25-34(30-6-7-30)36(26-39(35)60-41(40)31-8-10-33(44)11-9-31)46(61(2,52)53)12-13-54-14-15-55-16-17-56-18-19-57-20-21-58-22-23-59-28-29-4-3-5-32(24-29)37(47)27-38(48)43(50)51/h3-5,8-11,24-27,30,48H,6-7,12-23,28H2,1-2H3,(H,45,49)(H,50,51)/b38-27-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485979
PNG
(US10947210, Compound 02-10H)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCc3ccc(cc3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H43FN2O12S/c1-41-38(45)36-31-21-30(26-7-8-26)32(22-35(31)54-37(36)28-9-11-29(40)12-10-28)42(55(2,48)49)13-14-50-15-16-51-17-18-52-19-20-53-24-25-3-5-27(6-4-25)33(43)23-34(44)39(46)47/h3-6,9-12,21-23,26,44H,7-8,13-20,24H2,1-2H3,(H,41,45)(H,46,47)/b34-23-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485988
PNG
(US10947210, Compound 02-8F)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-21(37)23-6-4-22(5-7-23)20-42-17-16-41-15-14-36(44(3,39)40)29-19-30-28(18-27(29)24-8-9-24)31(33(38)35-2)32(43-30)25-10-12-26(34)13-11-25/h4-7,10-13,18-19,24H,8-9,14-17,20H2,1-3H3,(H,35,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486040
PNG
(US10947210, Compound 04-10 | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H35FN2O8S/c1-30-28(33)26-23-17-22(19-3-4-19)24(18-25(23)39-27(26)20-5-7-21(29)8-6-20)31(40(2,34)35)9-11-36-13-15-38-16-14-37-12-10-32/h5-8,17-19,32H,3-4,9-16H2,1-2H3,(H,30,33)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486056
PNG
(US10947210, Compound 06-6C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3cccc(c3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O8S/c1-35-32(37)30-27-18-26(22-7-8-22)28(19-29(27)44-31(30)23-9-11-25(34)12-10-23)36(45(3,39)40)13-14-42-15-16-43-20-21-5-4-6-24(17-21)33(38)41-2/h4-6,9-12,17-19,22H,7-8,13-16,20H2,1-3H3,(H,35,37)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486077
PNG
(US10947210, Compound 06-8B1)
Show SMILES CCOC(=O)c1ccc(COCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-4-44-34(39)25-7-5-22(6-8-25)21-43-18-17-42-16-15-37(46(3,40)41)29-20-30-28(19-27(29)23-9-10-23)31(33(38)36-2)32(45-30)24-11-13-26(35)14-12-24/h5-8,11-14,19-20,23H,4,9-10,15-18,21H2,1-3H3,(H,36,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486169
PNG
(US10947210, Compound 10-4B)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NCC(=O)NCCCC(C)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O8S/c1-17(30(39)40)5-4-12-33-25(36)15-34-26(37)16-35(44(3,41)42)23-14-24-22(13-21(23)18-6-7-18)27(29(38)32-2)28(43-24)19-8-10-20(31)11-9-19/h8-11,13-14,17-18H,4-7,12,15-16H2,1-3H3,(H,32,38)(H,33,36)(H,34,37)(H,39,40)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486247
PNG
(US10947210, Compound 14-6B)
Show SMILES CCOC(=O)c1cccc(OCCOCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C35H39FN2O9S/c1-4-45-35(40)25-6-5-7-27(20-25)46-19-18-44-17-16-43-15-14-38(48(3,41)42)30-22-31-29(21-28(30)23-8-9-23)32(34(39)37-2)33(47-31)24-10-12-26(36)13-11-24/h5-7,10-13,20-23H,4,8-9,14-19H2,1-3H3,(H,37,39)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486300
PNG
(US10947210, Compound 18-9A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(C(=O)OC)c(C)c3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-21-17-22(5-12-26(21)34(39)42-3)20-44-16-15-43-14-13-37(46(4,40)41)29-19-30-28(18-27(29)23-6-7-23)31(33(38)36-2)32(45-30)24-8-10-25(35)11-9-24/h5,8-12,17-19,23H,6-7,13-16,20H2,1-4H3,(H,36,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486316
PNG
(US10947210, Compound 25-4)
Show SMILES CCOC(=O)C(OCCOCCOCCN(c1cc2oc(c(C(=O)NC)c2cc1C1CC1)-c1ccc(F)cc1)S(C)(=O)=O)c1ccccc1
Show InChI InChI=1S/C36H41FN2O9S/c1-4-46-36(41)34(25-8-6-5-7-9-25)47-21-20-45-19-18-44-17-16-39(49(3,42)43)30-23-31-29(22-28(30)24-10-11-24)32(35(40)38-2)33(48-31)26-12-14-27(37)15-13-26/h5-9,12-15,22-24,34H,4,10-11,16-21H2,1-3H3,(H,38,40)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486339
PNG
(US10947210, Compound 30-5)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O6S/c1-21(37)25-8-4-6-22(18-25)7-5-16-41-17-15-36(43(3,39)40)29-20-30-28(19-27(29)23-9-10-23)31(33(38)35-2)32(42-30)24-11-13-26(34)14-12-24/h4,6,8,11-14,18-20,23H,5,7,9-10,15-17H2,1-3H3,(H,35,38)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486342
PNG
(US10947210, Compound 30-8)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOc3cccc(c3)C(=O)CC(=O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H37FN2O11S/c1-38-35(42)33-28-19-27(22-6-7-22)29(20-32(28)50-34(33)23-8-10-25(37)11-9-23)39(51(2,45)46)12-13-47-14-15-48-16-17-49-26-5-3-4-24(18-26)30(40)21-31(41)36(43)44/h3-5,8-11,18-20,22H,6-7,12-17,21H2,1-2H3,(H,38,42)(H,43,44)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485982
PNG
(US10947210, Compound 02-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-21(37)25-6-4-5-22(17-25)20-42-16-15-41-14-13-36(44(3,39)40)29-19-30-28(18-27(29)23-7-8-23)31(33(38)35-2)32(43-30)24-9-11-26(34)12-10-24/h4-6,9-12,17-19,23H,7-8,13-16,20H2,1-3H3,(H,35,38)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486003
PNG
(US10947210, Compound 02-8I)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCc3ccc(cc3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H47FN2O10S/c1-27(43)29-6-4-28(5-7-29)26-51-23-22-50-21-20-49-19-18-48-17-16-47-15-14-42(53(3,45)46)35-25-36-34(24-33(35)30-8-9-30)37(39(44)41-2)38(52-36)31-10-12-32(40)13-11-31/h4-7,10-13,24-25,30H,8-9,14-23,26H2,1-3H3,(H,41,44)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486008
PNG
(US10947210, Compound 02-9H)
Show SMILES CCOC(=O)C(\O)=C\C(=O)c1ccc(COCCOCCOCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C41H47FN2O12S/c1-4-55-41(48)36(46)25-35(45)29-7-5-27(6-8-29)26-54-22-21-53-20-19-52-18-17-51-16-15-44(57(3,49)50)34-24-37-33(23-32(34)28-9-10-28)38(40(47)43-2)39(56-37)30-11-13-31(42)14-12-30/h5-8,11-14,23-25,28,46H,4,9-10,15-22,26H2,1-3H3,(H,43,47)/b36-25-
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486116
PNG
(US10947210, Compound 09-14D)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NC3(CC3)C(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H35FN4O10S/c1-39-34(46)32-26-15-25(21-6-7-21)27(16-30(26)52-33(32)22-8-10-24(38)11-9-22)42(53(2,50)51)19-31(45)41-37(12-13-37)36(49)40-18-20-4-3-5-23(14-20)28(43)17-29(44)35(47)48/h3-5,8-11,14-17,21,44H,6-7,12-13,18-19H2,1-2H3,(H,39,46)(H,40,49)(H,41,45)(H,47,48)/b29-17-
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486193
PNG
(US10947210, Compound 11-5C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O8S/c1-36-33(38)31-28-20-27(23-8-9-23)29(21-30(28)45-32(31)24-10-12-26(35)13-11-24)37(46(3,40)41)15-17-44-19-18-43-16-14-22-4-6-25(7-5-22)34(39)42-2/h4-7,10-13,20-21,23H,8-9,14-19H2,1-3H3,(H,36,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486319
PNG
(US10947210, Compound 26-6A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC3(CCCC3)C(=O)OC(C)(C)C)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H47FN2O9S/c1-35(2,3)48-34(41)36(14-6-7-15-36)46-21-20-45-19-18-44-17-16-39(49(5,42)43)29-23-30-28(22-27(29)24-8-9-24)31(33(40)38-4)32(47-30)25-10-12-26(37)13-11-25/h10-13,22-24H,6-9,14-21H2,1-5H3,(H,38,40)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486320
PNG
(US10947210, Compound 26-6B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C)(C)C(=O)OC(C)(C)C)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H45FN2O9S/c1-33(2,3)46-32(39)34(4,5)44-19-18-43-17-16-42-15-14-37(47(7,40)41)27-21-28-26(20-25(27)22-8-9-22)29(31(38)36-6)30(45-28)23-10-12-24(35)13-11-23/h10-13,20-22H,8-9,14-19H2,1-7H3,(H,36,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486323
PNG
(US10947210, Compound 26-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C)(C)C(=O)NO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H38FN3O9S/c1-30(2,29(36)33-37)42-16-15-41-14-13-40-12-11-34(44(4,38)39)24-18-25-23(17-22(24)19-5-6-19)26(28(35)32-3)27(43-25)20-7-9-21(31)10-8-20/h7-10,17-19,37H,5-6,11-16H2,1-4H3,(H,32,35)(H,33,36)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486343
PNG
(US10947210, Compound 30-9)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCCOc3cccc(c3)C(=O)CC(=O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H37FN2O10S/c1-38-35(42)33-28-19-27(22-8-9-22)29(20-32(28)49-34(33)23-10-12-25(37)13-11-23)39(50(2,45)46)14-17-47-15-3-4-16-48-26-7-5-6-24(18-26)30(40)21-31(41)36(43)44/h5-7,10-13,18-20,22H,3-4,8-9,14-17,21H2,1-2H3,(H,38,42)(H,43,44)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485963
PNG
(US10947210, Compound 02-10B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H39FN2O11S/c1-39-36(43)34-29-19-28(24-6-7-24)30(20-33(29)51-35(34)25-8-10-27(38)11-9-25)40(52(2,46)47)12-13-48-14-15-49-16-17-50-22-23-4-3-5-26(18-23)31(41)21-32(42)37(44)45/h3-5,8-11,18-21,24,42H,6-7,12-17,22H2,1-2H3,(H,39,43)(H,44,45)/b32-21-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485972
PNG
(US10947210, Compound 02-10G)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3ccc(cc3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H39FN2O11S/c1-39-36(43)34-29-19-28(24-7-8-24)30(20-33(29)51-35(34)26-9-11-27(38)12-10-26)40(52(2,46)47)13-14-48-15-16-49-17-18-50-22-23-3-5-25(6-4-23)31(41)21-32(42)37(44)45/h3-6,9-12,19-21,24,42H,7-8,13-18,22H2,1-2H3,(H,39,43)(H,44,45)/b32-21-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486082
PNG
(US10947210, Compound 06-8B2)
Show SMILES CCCOC(=O)c1ccc(COCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C35H39FN2O8S/c1-4-16-45-35(40)26-7-5-23(6-8-26)22-44-19-18-43-17-15-38(47(3,41)42)30-21-31-29(20-28(30)24-9-10-24)32(34(39)37-2)33(46-31)25-11-13-27(36)14-12-25/h5-8,11-14,20-21,24H,4,9-10,15-19,22H2,1-3H3,(H,37,39)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486150
PNG
(US10947210, Compound 10-3A | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NCC(=O)NCCCCC(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O8S/c1-32-30(39)28-22-14-21(18-7-8-18)23(15-24(22)43-29(28)19-9-11-20(31)12-10-19)35(44(3,40)41)17-26(37)34-16-25(36)33-13-5-4-6-27(38)42-2/h9-12,14-15,18H,4-8,13,16-17H2,1-3H3,(H,32,39)(H,33,36)(H,34,37)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486324
PNG
(US10947210, Compound 27-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCCCOCC(=O)OC(C)(C)C)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H43FN2O8S/c1-33(2,3)44-29(37)21-42-17-8-6-7-16-41-18-15-36(45(5,39)40)27-20-28-26(19-25(27)22-9-10-22)30(32(38)35-4)31(43-28)23-11-13-24(34)14-12-23/h11-14,19-20,22H,6-10,15-18,21H2,1-5H3,(H,35,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486075
PNG
(US10947210, Compound 06-7E | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O9S/c1-36-33(38)31-28-19-27(23-7-8-23)29(20-30(28)46-32(31)24-9-11-26(35)12-10-24)37(47(2,41)42)13-14-43-15-16-44-17-18-45-21-22-3-5-25(6-4-22)34(39)40/h3-6,9-12,19-20,23H,7-8,13-18,21H2,1-2H3,(H,36,38)(H,39,40)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486344
PNG
(US10947210, Compound 30-10)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCCc3cccc(c3)C(=O)CC(=O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H43FN2O11S/c1-41-38(45)36-31-22-30(26-8-9-26)32(23-35(31)53-37(36)27-10-12-29(40)13-11-27)42(54(2,48)49)14-16-51-18-20-52-19-17-50-15-4-6-25-5-3-7-28(21-25)33(43)24-34(44)39(46)47/h3,5,7,10-13,21-23,26H,4,6,8-9,14-20,24H2,1-2H3,(H,41,45)(H,46,47)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486347
PNG
(US10947210, Compound 30-12)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCCCc3cccc(c3)C(=O)CC(=O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C38H41FN2O10S/c1-40-37(44)35-30-21-29(25-9-10-25)31(22-34(30)51-36(35)26-11-13-28(39)14-12-26)41(52(2,47)48)15-17-50-19-18-49-16-4-3-6-24-7-5-8-27(20-24)32(42)23-33(43)38(45)46/h5,7-8,11-14,20-22,25H,3-4,6,9-10,15-19,23H2,1-2H3,(H,40,44)(H,45,46)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485986
PNG
(US10947210, Compound 02-8D)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H47FN2O10S/c1-27(43)31-6-4-5-28(23-31)26-51-22-21-50-20-19-49-18-17-48-16-15-47-14-13-42(53(3,45)46)35-25-36-34(24-33(35)29-7-8-29)37(39(44)41-2)38(52-36)30-9-11-32(40)12-10-30/h4-6,9-12,23-25,29H,7-8,13-22,26H2,1-3H3,(H,41,44)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485991
PNG
(US10947210, Compound 02-8H)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCc3ccc(cc3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H43FN2O9S/c1-25(41)27-6-4-26(5-7-27)24-48-21-20-47-19-18-46-17-16-45-15-14-40(50(3,43)44)33-23-34-32(22-31(33)28-8-9-28)35(37(42)39-2)36(49-34)29-10-12-30(38)13-11-29/h4-7,10-13,22-23,28H,8-9,14-21,24H2,1-3H3,(H,39,42)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486039
PNG
(US10947210, Compound 03-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H37FN2O10S/c1-38-35(42)33-28-18-27(23-7-8-23)29(19-32(28)49-34(33)24-9-11-26(37)12-10-24)39(50(2,45)46)13-16-47-14-4-15-48-21-22-5-3-6-25(17-22)30(40)20-31(41)36(43)44/h3,5-6,9-12,17-20,23,41H,4,7-8,13-16,21H2,1-2H3,(H,38,42)(H,43,44)/b31-20-
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486055
PNG
(US10947210, Compound 06-6B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O8S/c1-35-32(37)30-27-18-26(22-8-9-22)28(19-29(27)44-31(30)23-10-12-25(34)13-11-23)36(45(3,39)40)14-15-42-16-17-43-20-21-4-6-24(7-5-21)33(38)41-2/h4-7,10-13,18-19,22H,8-9,14-17,20H2,1-3H3,(H,35,37)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486100
PNG
(US10947210, Compound 07-7)
Show SMILES CNC(=O)c1c(oc2cc(N(CCNC(=O)CNC(=O)CCCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H33FN4O8S/c1-31-29(39)27-21-14-20(17-6-7-17)22(15-23(21)42-28(27)18-8-10-19(30)11-9-18)34(43(2,40)41)13-12-32-25(36)16-33-24(35)4-3-5-26(37)38/h8-11,14-15,17H,3-7,12-13,16H2,1-2H3,(H,31,39)(H,32,36)(H,33,35)(H,37,38)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486101
PNG
(US10947210, Compound 07-10)
Show SMILES CCOC(=O)CCCc1cccc(c1)C(=O)NCC(=O)NCCN(c1cc2oc(c(C(=O)NC)c2cc1C1CC1)-c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C37H41FN4O8S/c1-4-49-33(44)10-6-8-23-7-5-9-26(19-23)36(45)41-22-32(43)40-17-18-42(51(3,47)48)30-21-31-29(20-28(30)24-11-12-24)34(37(46)39-2)35(50-31)25-13-15-27(38)16-14-25/h5,7,9,13-16,19-21,24H,4,6,8,10-12,17-18,22H2,1-3H3,(H,39,46)(H,40,43)(H,41,45)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486104
PNG
(US10947210, Compound 09-14B)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)N(C)CC(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H35FN4O10S/c1-38-35(46)33-26-14-25(21-7-8-21)27(15-30(26)51-34(33)22-9-11-24(37)12-10-22)41(52(3,49)50)19-32(45)40(2)18-31(44)39-17-20-5-4-6-23(13-20)28(42)16-29(43)36(47)48/h4-6,9-16,21,43H,7-8,17-19H2,1-3H3,(H,38,46)(H,39,44)(H,47,48)/b29-16-
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486295
PNG
(US10947210, Compound 16-6)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCOCc3ccc(cc3)C(=O)OC)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O7S/c1-36-33(38)31-28-19-27(23-11-12-23)29(20-30(28)44-32(31)24-13-15-26(35)16-14-24)37(45(3,40)41)17-5-4-6-18-43-21-22-7-9-25(10-8-22)34(39)42-2/h7-10,13-16,19-20,23H,4-6,11-12,17-18,21H2,1-3H3,(H,36,38)
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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486298
PNG
(US10947210, Compound 17A-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(F)c(c3)C(=O)NO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33F2N3O8S/c1-35-32(39)29-25-16-23(20-4-5-20)27(17-28(25)45-30(29)21-6-8-22(33)9-7-21)37(46(2,41)42)11-12-43-13-14-44-18-19-3-10-26(34)24(15-19)31(38)36-40/h3,6-10,15-17,20,40H,4-5,11-14,18H2,1-2H3,(H,35,39)(H,36,38)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486335
PNG
(US10947210, Compound 30-1)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCC(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H35FN2O8S/c1-19(33)18-39-15-14-38-13-12-37-11-10-32(41(3,35)36)25-17-26-24(16-23(25)20-4-5-20)27(29(34)31-2)28(40-26)21-6-8-22(30)9-7-21/h6-9,16-17,20H,4-5,10-15,18H2,1-3H3,(H,31,34)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486336
PNG
(US10947210, Compound 30-2)
Show SMILES CCOC(=O)C(C)OCCOCCOCCN(c1cc2oc(c(C(=O)NC)c2cc1C1CC1)-c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H39FN2O9S/c1-5-41-31(36)20(2)42-17-16-40-15-14-39-13-12-34(44(4,37)38)26-19-27-25(18-24(26)21-6-7-21)28(30(35)33-3)29(43-27)22-8-10-23(32)11-9-22/h8-11,18-21H,5-7,12-17H2,1-4H3,(H,33,35)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486349
PNG
(US10947210, Compound 30-14)
Show SMILES CCOC(=O)c1cc(COCCOCCN(c2cc3oc(c(C(=O)NC)c3cc2C2CC2)-c2ccc(F)cc2)S(C)(=O)=O)ccc1F
Show InChI InChI=1S/C34H36F2N2O8S/c1-4-45-34(40)26-17-21(5-12-28(26)36)20-44-16-15-43-14-13-38(47(3,41)42)29-19-30-27(18-25(29)22-6-7-22)31(33(39)37-2)32(46-30)23-8-10-24(35)11-9-23/h5,8-12,17-19,22H,4,6-7,13-16,20H2,1-3H3,(H,37,39)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486351
PNG
(US10947210, Compound 30-16)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCCCc3cccc(c3)C(=O)CC(=O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C40H45FN2O11S/c1-42-39(46)37-32-23-31(27-9-10-27)33(24-36(32)54-38(37)28-11-13-30(41)14-12-28)43(55(2,49)50)15-17-52-19-21-53-20-18-51-16-4-3-6-26-7-5-8-29(22-26)34(44)25-35(45)40(47)48/h5,7-8,11-14,22-24,27H,3-4,6,9-10,15-21,25H2,1-2H3,(H,42,46)(H,47,48)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
The reaction mixtures consisted of 50 mM Hepes-KOH, pH 7.5, 5 mM MgCl2, 5 mM DTT, 2% glycerol, 0.01% Triton® X-100, 0.5 uM polyA:U16 substrate, purif...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486039
PNG
(US10947210, Compound 03-8B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H37FN2O10S/c1-38-35(42)33-28-18-27(23-7-8-23)29(19-32(28)49-34(33)24-9-11-26(37)12-10-24)39(50(2,45)46)13-16-47-14-4-15-48-21-22-5-3-6-25(17-22)30(40)20-31(41)36(43)44/h3,5-6,9-12,17-20,23,41H,4,7-8,13-16,21H2,1-2H3,(H,38,42)(H,43,44)/b31-20-
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486296
PNG
(US10947210, Compound 16-7)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCOCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-35-32(37)30-27-18-26(22-10-11-22)28(19-29(27)43-31(30)23-12-14-25(34)15-13-23)36(44(2,40)41)16-4-3-5-17-42-20-21-6-8-24(9-7-21)33(38)39/h6-9,12-15,18-19,22H,3-5,10-11,16-17,20H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486317
PNG
(US10947210, Compound 25-5)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C(O)=O)c3ccccc3)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O9S/c1-36-33(38)30-27-20-26(22-8-9-22)28(21-29(27)46-31(30)24-10-12-25(35)13-11-24)37(47(2,41)42)14-15-43-16-17-44-18-19-45-32(34(39)40)23-6-4-3-5-7-23/h3-7,10-13,20-22,32H,8-9,14-19H2,1-2H3,(H,36,38)(H,39,40)
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485982
PNG
(US10947210, Compound 02-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3cccc(c3)C(C)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-21(37)25-6-4-5-22(17-25)20-42-16-15-41-14-13-36(44(3,39)40)29-19-30-28(18-27(29)23-7-8-23)31(33(38)35-2)32(43-30)24-9-11-26(34)12-10-24/h4-6,9-12,17-19,23H,7-8,13-16,20H2,1-3H3,(H,35,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486068
PNG
(US10947210, Compound 06-7C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3cccc(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33FN2O8S/c1-34-31(36)29-26-17-25(21-6-7-21)27(18-28(26)43-30(29)22-8-10-24(33)11-9-22)35(44(2,39)40)12-13-41-14-15-42-19-20-4-3-5-23(16-20)32(37)38/h3-5,8-11,16-18,21H,6-7,12-15,19H2,1-2H3,(H,34,36)(H,37,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486103
PNG
(US10947210, Compound 09-14A)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NCC(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H33FN4O10S/c1-37-34(45)32-25-13-24(20-6-7-20)26(14-29(25)50-33(32)21-8-10-23(36)11-9-21)40(51(2,48)49)18-31(44)39-17-30(43)38-16-19-4-3-5-22(12-19)27(41)15-28(42)35(46)47/h3-5,8-15,20,42H,6-7,16-18H2,1-2H3,(H,37,45)(H,38,43)(H,39,44)(H,46,47)/b28-15-
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486105
PNG
(US10947210, Compound 09-14C)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NC(C)(C)C(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H37FN4O10S/c1-37(2,36(49)40-18-20-6-5-7-23(14-20)28(43)17-29(44)35(47)48)41-31(45)19-42(53(4,50)51)27-16-30-26(15-25(27)21-8-9-21)32(34(46)39-3)33(52-30)22-10-12-24(38)13-11-22/h5-7,10-17,21,44H,8-9,18-19H2,1-4H3,(H,39,46)(H,40,49)(H,41,45)(H,47,48)/b29-17-
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486147
PNG
(US10947210, Compound 09-14E)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NC3(CCCC3)C(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C39H39FN4O10S/c1-41-36(48)34-28-17-27(23-8-9-23)29(18-32(28)54-35(34)24-10-12-26(40)13-11-24)44(55(2,52)53)21-33(47)43-39(14-3-4-15-39)38(51)42-20-22-6-5-7-25(16-22)30(45)19-31(46)37(49)50/h5-7,10-13,16-19,23,46H,3-4,8-9,14-15,20-21H2,1-2H3,(H,41,48)(H,42,51)(H,43,47)(H,49,50)/b31-19-
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486299
PNG
(US10947210, Compound 17B-8)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(OC)c(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O9S/c1-35-32(37)30-25-17-24(21-5-6-21)27(18-29(25)45-31(30)22-7-9-23(34)10-8-22)36(46(3,40)41)12-13-43-14-15-44-19-20-4-11-28(42-2)26(16-20)33(38)39/h4,7-11,16-18,21H,5-6,12-15,19H2,1-3H3,(H,35,37)(H,38,39)
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486313
PNG
(US10947210, Compound 23-6C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCC(=O)NO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H34FN3O9S/c1-30-28(34)26-22-15-21(18-3-4-18)23(16-24(22)41-27(26)19-5-7-20(29)8-6-19)32(42(2,36)37)9-10-38-11-12-39-13-14-40-17-25(33)31-35/h5-8,15-16,18,35H,3-4,9-14,17H2,1-2H3,(H,30,34)(H,31,33)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486102
PNG
(US10947210, Compound 08-6)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOC(=O)CNC(=O)CCCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H32FN3O9S/c1-31-29(38)27-21-14-20(17-6-7-17)22(15-23(21)42-28(27)18-8-10-19(30)11-9-18)33(43(2,39)40)12-13-41-26(37)16-32-24(34)4-3-5-25(35)36/h8-11,14-15,17H,3-7,12-13,16H2,1-2H3,(H,31,38)(H,32,34)(H,35,36)
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486149
PNG
(US10947210, Compound 09-14F)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(=O)NC(C)C(=O)NCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H35FN4O10S/c1-19(34(45)39-17-20-5-4-6-23(13-20)28(42)16-29(43)36(47)48)40-31(44)18-41(52(3,49)50)27-15-30-26(14-25(27)21-7-8-21)32(35(46)38-2)33(51-30)22-9-11-24(37)12-10-22/h4-6,9-16,19,21,43H,7-8,17-18H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)(H,47,48)/b29-16-
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486297
PNG
(US10947210, Compound 17A-8A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(F)c(c3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H32F2N2O8S/c1-35-31(37)29-25-16-23(20-4-5-20)27(17-28(25)44-30(29)21-6-8-22(33)9-7-21)36(45(2,40)41)11-12-42-13-14-43-18-19-3-10-26(34)24(15-19)32(38)39/h3,6-10,15-17,20H,4-5,11-14,18H2,1-2H3,(H,35,37)(H,38,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486312
PNG
(US10947210, Compound 23-6B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOC(C)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H35FN2O9S/c1-18(29(34)35)40-15-14-39-13-12-38-11-10-32(42(3,36)37)24-17-25-23(16-22(24)19-4-5-19)26(28(33)31-2)27(41-25)20-6-8-21(30)9-7-20/h6-9,16-19H,4-5,10-15H2,1-3H3,(H,31,33)(H,34,35)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486040
PNG
(US10947210, Compound 04-10 | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H35FN2O8S/c1-30-28(33)26-23-17-22(19-3-4-19)24(18-25(23)39-27(26)20-5-7-21(29)8-6-20)31(40(2,34)35)9-11-36-13-15-38-16-14-37-12-10-32/h5-8,17-19,32H,3-4,9-16H2,1-2H3,(H,30,33)
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486054
PNG
(US10947210, Compound 06-6A | US10947210, Compound ...)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccccc3C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33FN2O8S/c1-34-31(36)29-26-17-25(20-7-8-20)27(18-28(26)43-30(29)21-9-11-23(33)12-10-21)35(44(2,39)40)13-14-41-15-16-42-19-22-5-3-4-6-24(22)32(37)38/h3-6,9-12,17-18,20H,7-8,13-16,19H2,1-2H3,(H,34,36)(H,37,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486241
PNG
(US10947210, Compound 13-8D)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCCCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37FN2O6S/c1-36-33(38)31-28-20-27(23-13-14-23)29(21-30(28)43-32(31)24-15-17-26(35)18-16-24)37(44(2,41)42)19-7-5-3-4-6-8-22-9-11-25(12-10-22)34(39)40/h9-12,15-18,20-21,23H,3-8,13-14,19H2,1-2H3,(H,36,38)(H,39,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486067
PNG
(US10947210, Compound 06-7B)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33FN2O8S/c1-34-31(36)29-26-17-25(21-7-8-21)27(18-28(26)43-30(29)22-9-11-24(33)12-10-22)35(44(2,39)40)13-14-41-15-16-42-19-20-3-5-23(6-4-20)32(37)38/h3-6,9-12,17-18,21H,7-8,13-16,19H2,1-2H3,(H,34,36)(H,37,38)
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486311
PNG
(US10947210, Compound 23-6A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCC(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H33FN2O9S/c1-30-28(34)26-22-15-21(18-3-4-18)23(16-24(22)40-27(26)19-5-7-20(29)8-6-19)31(41(2,35)36)9-10-37-11-12-38-13-14-39-17-25(32)33/h5-8,15-16,18H,3-4,9-14,17H2,1-2H3,(H,30,34)(H,32,33)
PDB

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n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486309
PNG
(US10947210, Compound 22-12)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H35FN2O9S/c1-37-34(41)32-27-18-26(22-8-9-22)28(19-31(27)47-33(32)23-10-12-25(36)13-11-23)38(48(2,44)45)14-16-46-15-4-6-21-5-3-7-24(17-21)29(39)20-30(40)35(42)43/h3,5,7,10-13,17-20,22,40H,4,6,8-9,14-16H2,1-2H3,(H,37,41)(H,42,43)/b30-20-
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485959
PNG
(US10947210, Compound 02-10A)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H35FN2O10S/c1-37-34(41)32-27-17-26(22-6-7-22)28(18-31(27)48-33(32)23-8-10-25(36)11-9-23)38(49(2,44)45)12-13-46-14-15-47-20-21-4-3-5-24(16-21)29(39)19-30(40)35(42)43/h3-5,8-11,16-19,22,40H,6-7,12-15,20H2,1-2H3,(H,37,41)(H,42,43)/b30-19-
PDB

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n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485969
PNG
(US10947210, Compound 02-10F)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCc3ccc(cc3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H35FN2O10S/c1-37-34(41)32-27-17-26(22-7-8-22)28(18-31(27)48-33(32)24-9-11-25(36)12-10-24)38(49(2,44)45)13-14-46-15-16-47-20-21-3-5-23(6-4-21)29(39)19-30(40)35(42)43/h3-6,9-12,17-19,22,40H,7-8,13-16,20H2,1-2H3,(H,37,41)(H,42,43)/b30-19-
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM485968
PNG
(US10947210, Compound 02-10E)
Show SMILES CNC(=O)c1c(oc2cc(N(CCOCCOCCOCCOCCOCCOCc3cccc(c3)C(=O)\C=C(/O)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C43H51FN2O14S/c1-45-42(49)40-35-25-34(30-6-7-30)36(26-39(35)60-41(40)31-8-10-33(44)11-9-31)46(61(2,52)53)12-13-54-14-15-55-16-17-56-18-19-57-20-21-58-22-23-59-28-29-4-3-5-32(24-29)37(47)27-38(48)43(50)51/h3-5,8-11,24-27,30,48H,6-7,12-23,28H2,1-2H3,(H,45,49)(H,50,51)/b38-27-
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a 550n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus genotype 3a (isolate k3a) (HCV))
BDBM486239
PNG
(US10947210, Compound 13-8C)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCCOCCc3ccc(cc3)C(O)=O)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H35FN2O7S/c1-35-32(37)30-27-19-26(22-9-10-22)28(20-29(27)43-31(30)23-11-13-25(34)14-12-23)36(44(2,40)41)16-3-4-17-42-18-15-21-5-7-24(8-6-21)33(38)39/h5-8,11-14,19-20,22H,3-4,9-10,15-18H2,1-2H3,(H,35,37)(H,38,39)
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



COCRYSTAL PHARMA, INC.

US Patent


Assay Description
HCV replicon assay is based on the luciferase reporter cell line (Huh-luc/neo-ET). This reporter cell line is a human liver carcinoma cell line (Huh-...


US Patent US10947210 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%