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Patent code US10947215

Compile Data Set for Download or QSAR

Found 458 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299032
PNG
(US10125118, Example 438 | US10947215, Example 438)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C34H42N8O2/c1-23(42-14-12-40(2)13-15-42)25-8-10-27(11-9-25)26-6-4-24(5-7-26)22-44-32-20-36-19-31(32)39-34(43)30-16-28(17-37-33(30)35)29-18-38-41(3)21-29/h4-11,16-18,21,23,31-32,36H,12-15,19-20,22H2,1-3H3,(H2,35,37)(H,39,43)/t23?,31-,32-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298775
PNG
(US10125118, Example 181 | US10947215, Example 181)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCN(CCO)CC2)cc1
Show InChI InChI=1S/C35H43N7O3/c1-40-23-30(21-38-40)29-19-31(34(36)37-20-29)35(44)39-32-3-2-4-33(32)45-24-26-7-11-28(12-8-26)27-9-5-25(6-10-27)22-42-15-13-41(14-16-42)17-18-43/h5-12,19-21,23,32-33,43H,2-4,13-18,22,24H2,1H3,(H2,36,37)(H,39,44)/t32-,33-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298805
PNG
(US10125118, Example 211 | US10947215, Example 211)
Show SMILES CC(N1C[C@H](C)N(CCO)[C@H](C)C1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C38H49N7O3/c1-25-21-44(22-26(2)45(25)16-17-46)27(3)29-12-14-31(15-13-29)30-10-8-28(9-11-30)24-48-36-7-5-6-35(36)42-38(47)34-18-32(19-40-37(34)39)33-20-41-43(4)23-33/h8-15,18-20,23,25-27,35-36,46H,5-7,16-17,21-22,24H2,1-4H3,(H2,39,40)(H,42,47)/t25-,26+,27?,35-,36-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298812
PNG
(US10125118, Example 218 | US10947215, Example 218)
Show SMILES C[C@@H](N1CCN(CCO)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C36H45N7O3/c1-25(43-16-14-42(15-17-43)18-19-44)27-10-12-29(13-11-27)28-8-6-26(7-9-28)24-46-34-5-3-4-33(34)40-36(45)32-20-30(21-38-35(32)37)31-22-39-41(2)23-31/h6-13,20-23,25,33-34,44H,3-5,14-19,24H2,1-2H3,(H2,37,38)(H,40,45)/t25-,33+,34+/m1/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298825
PNG
(US10125118, Example 231 | US10947215, Example 231)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(Cl)cnc2N)cc1
Show InChI InChI=1S/C31H38ClN5O2/c1-21(37-16-14-36(2)15-17-37)23-10-12-25(13-11-23)24-8-6-22(7-9-24)20-39-29-5-3-4-28(29)35-31(38)27-18-26(32)19-34-30(27)33/h6-13,18-19,21,28-29H,3-5,14-17,20H2,1-2H3,(H2,33,34)(H,35,38)/t21?,28-,29-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298832
PNG
(US10125118, Example 238 | US10947215, Example 238)
Show SMILES CC(N1CCN(CCO)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cccnc2F)cc1
Show InChI InChI=1S/C37H43FN6O3/c1-25(44-18-16-43(17-19-44)20-21-45)27-11-13-29(14-12-27)28-9-7-26(8-10-28)24-47-34-6-2-5-33(34)42-37(46)32-22-30(23-41-36(32)39)31-4-3-15-40-35(31)38/h3-4,7-15,22-23,25,33-34,45H,2,5-6,16-21,24H2,1H3,(H2,39,41)(H,42,46)/t25?,33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298931
PNG
(US10125118, Example 337 | US10947215, Example 337)
Show SMILES Cc1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(CN3CCC(C3)N3CCOCC3)cc2)cc1C
Show InChI InChI=1S/C35H45N5O3/c1-24-6-7-27(18-25(24)2)23-43-33-5-3-4-32(33)38-35(41)31-19-29(20-37-34(31)36)28-10-8-26(9-11-28)21-39-13-12-30(22-39)40-14-16-42-17-15-40/h6-11,18-20,30,32-33H,3-5,12-17,21-23H2,1-2H3,(H2,36,37)(H,38,41)/t30?,32-,33-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298963
PNG
(US10125118, Example 369 | US10947215, Example 369)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3ccc(CO)cc3)cc2)CC1
Show InChI InChI=1S/C37H43N5O3/c1-41-17-19-42(20-18-41)23-26-5-11-29(12-6-26)30-15-9-28(10-16-30)25-45-35-4-2-3-34(35)40-37(44)33-21-32(22-39-36(33)38)31-13-7-27(24-43)8-14-31/h5-16,21-22,34-35,43H,2-4,17-20,23-25H2,1H3,(H2,38,39)(H,40,44)/t34-,35-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298972
PNG
(US10125118, Example 378 | US10947215, Example 378)
Show SMILES CC1CCN(Cc2ccc(cc2)-c2cnc(N)c(c2)C(=O)N[C@H]2CCC[C@@H]2OCc2ccc(cc2)-c2ccc(CN3CCN(C)CC3)cc2)CC1
Show InChI InChI=1S/C43H54N6O2/c1-31-18-20-48(21-19-31)28-32-8-14-37(15-9-32)38-26-39(42(44)45-27-38)43(50)46-40-4-3-5-41(40)51-30-34-10-16-36(17-11-34)35-12-6-33(7-13-35)29-49-24-22-47(2)23-25-49/h6-17,26-27,31,40-41H,3-5,18-25,28-30H2,1-2H3,(H2,44,45)(H,46,50)/t40-,41-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298974
PNG
(US10125118, Example 380 | US10947215, Example 380)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(c3)C3CCOCC3)cc2)CC1
Show InChI InChI=1S/C38H47N7O3/c1-43-15-17-44(18-16-43)24-27-5-9-29(10-6-27)30-11-7-28(8-12-30)26-48-36-4-2-3-35(36)42-38(46)34-21-31(22-40-37(34)39)32-23-41-45(25-32)33-13-19-47-20-14-33/h5-12,21-23,25,33,35-36H,2-4,13-20,24,26H2,1H3,(H2,39,40)(H,42,46)/t35-,36-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298976
PNG
(US10125118, Example 382 | US10947215, Example 382)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)C3=CCCCC3)cc2)CC1
Show InChI InChI=1S/C36H45N5O2/c1-40-18-20-41(21-19-40)24-26-10-14-29(15-11-26)30-16-12-27(13-17-30)25-43-34-9-5-8-33(34)39-36(42)32-22-31(23-38-35(32)37)28-6-3-2-4-7-28/h6,10-17,22-23,33-34H,2-5,7-9,18-21,24-25H2,1H3,(H2,37,38)(H,39,42)/t33-,34-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298980
PNG
(US10125118, Example 386 | US10947215, Example 386)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3ccc(F)nc3)cc2)CC1
Show InChI InChI=1S/C35H39FN6O2/c1-41-15-17-42(18-16-41)22-24-5-9-26(10-6-24)27-11-7-25(8-12-27)23-44-32-4-2-3-31(32)40-35(43)30-19-29(21-39-34(30)37)28-13-14-33(36)38-20-28/h5-14,19-21,31-32H,2-4,15-18,22-23H2,1H3,(H2,37,39)(H,40,43)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM486757
PNG
(US10947215, Example 388)
Show SMILES CCc1cc(CO[C@H]2CN(C[C@@H]2NC(=O)c2cc(Br)cnc2N)C(=O)OC(C)(C)C)ccc1C
Show InChI InChI=1S/C25H33BrN4O4/c1-6-17-9-16(8-7-15(17)2)14-33-21-13-30(24(32)34-25(3,4)5)12-20(21)29-23(31)19-10-18(26)11-28-22(19)27/h7-11,20-21H,6,12-14H2,1-5H3,(H2,27,28)(H,29,31)/t20-,21-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298989
PNG
(US10125118, Example 395 | US10947215, Example 395)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccncc2)ccc1C
Show InChI InChI=1S/C25H29N5O2/c1-3-18-10-17(5-4-16(18)2)15-32-23-14-28-13-22(23)30-25(31)21-11-20(12-29-24(21)26)19-6-8-27-9-7-19/h4-12,22-23,28H,3,13-15H2,1-2H3,(H2,26,29)(H,30,31)/t22-,23-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298995
PNG
(US10125118, Example 401 | US10947215, Example 401)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(NS(C)(=O)=O)cc2)ccc1C
Show InChI InChI=1S/C27H33N5O4S/c1-4-19-11-18(6-5-17(19)2)16-36-25-15-29-14-24(25)31-27(33)23-12-21(13-30-26(23)28)20-7-9-22(10-8-20)32-37(3,34)35/h5-13,24-25,29,32H,4,14-16H2,1-3H3,(H2,28,30)(H,31,33)/t24-,25-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299006
PNG
(US10125118, Example 412 | US10947215, Example 412)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(c2)C2CCNCC2)ccc1C
Show InChI InChI=1S/C28H37N7O2/c1-3-20-10-19(5-4-18(20)2)17-37-26-15-31-14-25(26)34-28(36)24-11-21(12-32-27(24)29)22-13-33-35(16-22)23-6-8-30-9-7-23/h4-5,10-13,16,23,25-26,30-31H,3,6-9,14-15,17H2,1-2H3,(H2,29,32)(H,34,36)/t25-,26-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299007
PNG
(US10125118, Example 413 | US10947215, Example 413)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(c2)C2CCN(C)CC2)ccc1C
Show InChI InChI=1S/C29H39N7O2/c1-4-21-11-20(6-5-19(21)2)18-38-27-16-31-15-26(27)34-29(37)25-12-22(13-32-28(25)30)23-14-33-36(17-23)24-7-9-35(3)10-8-24/h5-6,11-14,17,24,26-27,31H,4,7-10,15-16,18H2,1-3H3,(H2,30,32)(H,34,37)/t26-,27-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298731
PNG
(US10125118, Example 137 | US10947215, Example 137)
Show SMILES CN(C)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C30H34N6O2/c1-35(2)25-13-11-22(12-14-25)21-9-7-20(8-10-21)19-38-28-6-4-5-27(28)34-30(37)26-15-23(16-32-29(26)31)24-17-33-36(3)18-24/h7-18,27-28H,4-6,19H2,1-3H3,(H2,31,32)(H,34,37)/t27-,28-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298736
PNG
(US10125118, Example 142 | US10947215, Example 142)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CO)cc1
Show InChI InChI=1S/C29H31N5O3/c1-34-16-24(15-32-34)23-13-25(28(30)31-14-23)29(36)33-26-3-2-4-27(26)37-18-20-7-11-22(12-8-20)21-9-5-19(17-35)6-10-21/h5-16,26-27,35H,2-4,17-18H2,1H3,(H2,30,31)(H,33,36)/t26-,27-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298742
PNG
(US10125118, Example 148 | US10947215, Example 148)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C32H38N8O2/c1-38-12-14-40(15-13-38)30-11-10-24(17-34-30)23-8-6-22(7-9-23)21-42-29-5-3-4-28(29)37-32(41)27-16-25(18-35-31(27)33)26-19-36-39(2)20-26/h6-11,16-20,28-29H,3-5,12-15,21H2,1-2H3,(H2,33,35)(H,37,41)/t28-,29-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM486802
PNG
(US10947215, Example 433)
Show SMILES CCc1cc(CO[C@H]2CN(C)C[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(c2)C2CCN(C)CC2)ccc1C
Show InChI InChI=1S/C30H41N7O2/c1-5-22-12-21(7-6-20(22)2)19-39-28-18-36(4)17-27(28)34-30(38)26-13-23(14-32-29(26)31)24-15-33-37(16-24)25-8-10-35(3)11-9-25/h6-7,12-16,25,27-28H,5,8-11,17-19H2,1-4H3,(H2,31,32)(H,34,38)/t27-,28-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299031
PNG
(US10125118, Example 437 | US10947215, Example 437)
Show SMILES CN1C[C@H](NC(=O)c2cc(cnc2N)-c2cnn(C)c2)[C@H](C1)OCc1ccc(cc1)-c1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C35H41F3N8O2/c1-43-10-12-46(13-11-43)19-26-9-8-25(15-30(26)35(36,37)38)24-6-4-23(5-7-24)22-48-32-21-44(2)20-31(32)42-34(47)29-14-27(16-40-33(29)39)28-17-41-45(3)18-28/h4-9,14-18,31-32H,10-13,19-22H2,1-3H3,(H2,39,40)(H,42,47)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299040
PNG
(US10125118, Example 446 | US10947215, Example 446)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CNC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCN(CCO)CC2)cc1
Show InChI InChI=1S/C34H42N8O3/c1-40-22-29(18-38-40)28-16-30(33(35)37-17-28)34(44)39-31-19-36-20-32(31)45-23-25-4-8-27(9-5-25)26-6-2-24(3-7-26)21-42-12-10-41(11-13-42)14-15-43/h2-9,16-18,22,31-32,36,43H,10-15,19-21,23H2,1H3,(H2,35,37)(H,39,44)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298790
PNG
(US10125118, Example 196 | US10947215, Example 196)
Show SMILES CN1CCN(Cc2c(F)cc(cc2F)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C34H39F2N7O2/c1-41-10-12-43(13-11-41)20-28-29(35)15-24(16-30(28)36)23-8-6-22(7-9-23)21-45-32-5-3-4-31(32)40-34(44)27-14-25(17-38-33(27)37)26-18-39-42(2)19-26/h6-9,14-19,31-32H,3-5,10-13,20-21H2,1-2H3,(H2,37,38)(H,40,44)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298796
PNG
(US10125118, Example 202 | US10947215, Example 202)
Show SMILES CN1CCN(Cc2ccc(c(Cl)c2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C34H40ClN7O2/c1-40-12-14-42(15-13-40)20-24-8-11-28(30(35)16-24)25-9-6-23(7-10-25)22-44-32-5-3-4-31(32)39-34(43)29-17-26(18-37-33(29)36)27-19-38-41(2)21-27/h6-11,16-19,21,31-32H,3-5,12-15,20,22H2,1-2H3,(H2,36,37)(H,39,43)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298808
PNG
(US10125118, Example 214 | US10947215, Example 214)
Show SMILES C[C@@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C35H43N7O2/c1-24(42-17-15-40(2)16-18-42)26-11-13-28(14-12-26)27-9-7-25(8-10-27)23-44-33-6-4-5-32(33)39-35(43)31-19-29(20-37-34(31)36)30-21-38-41(3)22-30/h7-14,19-22,24,32-33H,4-6,15-18,23H2,1-3H3,(H2,36,37)(H,39,43)/t24-,32+,33+/m1/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298814
PNG
(US10125118, Example 220 | US10947215, Example 220)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(cc1)C1(CC1)N1CCN(CCO)CC1
Show InChI InChI=1S/C37H45N7O3/c1-42-24-30(23-40-42)29-21-32(35(38)39-22-29)36(46)41-33-3-2-4-34(33)47-25-26-5-7-27(8-6-26)28-9-11-31(12-10-28)37(13-14-37)44-17-15-43(16-18-44)19-20-45/h5-12,21-24,33-34,45H,2-4,13-20,25H2,1H3,(H2,38,39)(H,41,46)/t33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298816
PNG
(US10125118, Example 222 | US10125118, Example 223 ...)
Show SMILES C[C@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(F)nc2)cc1
Show InChI InChI=1S/C36H41FN6O2/c1-24(43-18-16-42(2)17-19-43)26-10-12-28(13-11-26)27-8-6-25(7-9-27)23-45-33-5-3-4-32(33)41-36(44)31-20-30(22-40-35(31)38)29-14-15-34(37)39-21-29/h6-15,20-22,24,32-33H,3-5,16-19,23H2,1-2H3,(H2,38,40)(H,41,44)/t24-,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298816
PNG
(US10125118, Example 222 | US10125118, Example 223 ...)
Show SMILES C[C@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(F)nc2)cc1
Show InChI InChI=1S/C36H41FN6O2/c1-24(43-18-16-42(2)17-19-43)26-10-12-28(13-11-26)27-8-6-25(7-9-27)23-45-33-5-3-4-32(33)41-36(44)31-20-30(22-40-35(31)38)29-14-15-34(37)39-21-29/h6-15,20-22,24,32-33H,3-5,16-19,23H2,1-2H3,(H2,38,40)(H,41,44)/t24-,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298819
PNG
(US10125118, Example 225 | US10947215, Example 225)
Show SMILES CN1CCN(CC1)C(C)(C)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(F)nc2)cc1
Show InChI InChI=1S/C37H43FN6O2/c1-37(2,44-19-17-43(3)18-20-44)30-14-11-27(12-15-30)26-9-7-25(8-10-26)24-46-33-6-4-5-32(33)42-36(45)31-21-29(23-41-35(31)39)28-13-16-34(38)40-22-28/h7-16,21-23,32-33H,4-6,17-20,24H2,1-3H3,(H2,39,41)(H,42,45)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298821
PNG
(US10125118, Example 227 | US10947215, Example 227)
Show SMILES C[C@@H](N1CCN(CCO)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(F)nc2)cc1
Show InChI InChI=1S/C37H43FN6O3/c1-25(44-17-15-43(16-18-44)19-20-45)27-9-11-29(12-10-27)28-7-5-26(6-8-28)24-47-34-4-2-3-33(34)42-37(46)32-21-31(23-41-36(32)39)30-13-14-35(38)40-22-30/h5-14,21-23,25,33-34,45H,2-4,15-20,24H2,1H3,(H2,39,41)(H,42,46)/t25-,33+,34+/m1/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298835
PNG
(US10125118, Example 241 | US10947215, Example 241)
Show SMILES COC(=O)CN1CCC(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C37H44N6O4/c1-42-22-31(21-40-42)30-19-32(36(38)39-20-30)37(45)41-33-4-3-5-34(33)47-24-27-8-12-29(13-9-27)28-10-6-25(7-11-28)18-26-14-16-43(17-15-26)23-35(44)46-2/h6-13,19-22,26,33-34H,3-5,14-18,23-24H2,1-2H3,(H2,38,39)(H,41,45)/t33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298839
PNG
(US10125118, Example 245 | US10947215, Example 245)
Show SMILES CN(C)CCOc1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C32H38N6O3/c1-37(2)15-16-40-27-13-11-24(12-14-27)23-9-7-22(8-10-23)21-41-30-6-4-5-29(30)36-32(39)28-17-25(18-34-31(28)33)26-19-35-38(3)20-26/h7-14,17-20,29-30H,4-6,15-16,21H2,1-3H3,(H2,33,34)(H,36,39)/t29-,30-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298840
PNG
(US10125118, Example 246 | US10947215, Example 246)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C33H40N6O3/c1-38(2)16-5-17-41-28-14-12-25(13-15-28)24-10-8-23(9-11-24)22-42-31-7-4-6-30(31)37-33(40)29-18-26(19-35-32(29)34)27-20-36-39(3)21-27/h8-15,18-21,30-31H,4-7,16-17,22H2,1-3H3,(H2,34,35)(H,37,40)/t30-,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298845
PNG
(US10125118, Example 251 | US10947215, Example 251)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)C#CCCCCO
Show InChI InChI=1S/C28H33N5O3/c1-33-18-23(17-31-33)22-15-24(27(29)30-16-22)28(35)32-25-8-6-9-26(25)36-19-21-12-10-20(11-13-21)7-4-2-3-5-14-34/h10-13,15-18,25-26,34H,2-3,5-6,8-9,14,19H2,1H3,(H2,29,30)(H,32,35)/t25-,26-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298962
PNG
(US10125118, Example 368 | US10947215, Example 368)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3ccc(CN4CCN(C)CC4)cc3)cc2)CC1
Show InChI InChI=1S/C42H53N7O2/c1-46-18-22-48(23-19-46)28-31-6-12-34(13-7-31)35-16-10-33(11-17-35)30-51-40-5-3-4-39(40)45-42(50)38-26-37(27-44-41(38)43)36-14-8-32(9-15-36)29-49-24-20-47(2)21-25-49/h6-17,26-27,39-40H,3-5,18-25,28-30H2,1-2H3,(H2,43,44)(H,45,50)/t39-,40-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298964
PNG
(US10125118, Example 370 | US10947215, Example 370)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cccc(C)c3)cc2)CC1
Show InChI InChI=1S/C37H43N5O2/c1-26-5-3-6-31(21-26)32-22-33(36(38)39-23-32)37(43)40-34-7-4-8-35(34)44-25-28-11-15-30(16-12-28)29-13-9-27(10-14-29)24-42-19-17-41(2)18-20-42/h3,5-6,9-16,21-23,34-35H,4,7-8,17-20,24-25H2,1-2H3,(H2,38,39)(H,40,43)/t34-,35-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298988
PNG
(US10125118, Example 394 | US10947215, Example 394)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccccc2)ccc1C
Show InChI InChI=1S/C26H30N4O2/c1-3-19-11-18(10-9-17(19)2)16-32-24-15-28-14-23(24)30-26(31)22-12-21(13-29-25(22)27)20-7-5-4-6-8-20/h4-13,23-24,28H,3,14-16H2,1-2H3,(H2,27,29)(H,30,31)/t23-,24-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM486769
PNG
(US10947215, Example 400)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(cc2)C#N)ccc1C
Show InChI InChI=1S/C27H29N5O2/c1-3-20-10-19(5-4-17(20)2)16-34-25-15-30-14-24(25)32-27(33)23-11-22(13-31-26(23)29)21-8-6-18(12-28)7-9-21/h4-11,13,24-25,30H,3,14-16H2,1-2H3,(H2,29,31)(H,32,33)/t24-,25-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298739
PNG
(US10125118, Example 145 | US10947215, Example 145)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CCN)cc1
Show InChI InChI=1S/C30H34N6O2/c1-36-18-25(17-34-36)24-15-26(29(32)33-16-24)30(37)35-27-3-2-4-28(27)38-19-21-7-11-23(12-8-21)22-9-5-20(6-10-22)13-14-31/h5-12,15-18,27-28H,2-4,13-14,19,31H2,1H3,(H2,32,33)(H,35,37)/t27-,28-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299030
PNG
(US10125118, Example 436 | US10947215, Example 436)
Show SMILES CN1CCN(Cc2ccc(cc2C(F)(F)F)-c2ccc(CO[C@H]3CNC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C34H39F3N8O2/c1-43-9-11-45(12-10-43)20-25-8-7-24(14-29(25)34(35,36)37)23-5-3-22(4-6-23)21-47-31-18-39-17-30(31)42-33(46)28-13-26(15-40-32(28)38)27-16-41-44(2)19-27/h3-8,13-16,19,30-31,39H,9-12,17-18,20-21H2,1-2H3,(H2,38,40)(H,42,46)/t30-,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299039
PNG
(US10125118, Example 445 | US10947215, Example 445)
Show SMILES CN1C[C@H](NC(=O)c2cc(cnc2N)-c2cnn(C)c2)[C@H](C1)OCc1ccc(cc1)-c1ccc(CN2CCN(CCO)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C36H43F3N8O3/c1-44-21-32(43-35(49)30-15-28(17-41-34(30)40)29-18-42-45(2)19-29)33(22-44)50-23-24-3-5-25(6-4-24)26-7-8-27(31(16-26)36(37,38)39)20-47-11-9-46(10-12-47)13-14-48/h3-8,15-19,32-33,48H,9-14,20-23H2,1-2H3,(H2,40,41)(H,43,49)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299047
PNG
(US10125118, Example 453 | US10947215, Example 453)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1COC[C@@H]1OCc1ccc(cc1)-c1ccc(cc1)C(C)(C)N1CCN(CCO)CC1
Show InChI InChI=1S/C36H45N7O4/c1-36(2,43-14-12-42(13-15-43)16-17-44)30-10-8-27(9-11-30)26-6-4-25(5-7-26)22-47-33-24-46-23-32(33)40-35(45)31-18-28(19-38-34(31)37)29-20-39-41(3)21-29/h4-11,18-21,32-33,44H,12-17,22-24H2,1-3H3,(H2,37,38)(H,40,45)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM299048
PNG
(US10125118, Example 454 | US10947215, Example 454)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3COCC3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C33H39N7O3/c1-38-11-13-40(14-12-38)18-23-3-7-25(8-4-23)26-9-5-24(6-10-26)20-43-31-22-42-21-30(31)37-33(41)29-15-27(16-35-32(29)34)28-17-36-39(2)19-28/h3-10,15-17,19,30-31H,11-14,18,20-22H2,1-2H3,(H2,34,35)(H,37,41)/t30?,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298787
PNG
(US10125118, Example 193 | US10947215, Example 193)
Show SMILES CN(C)C1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)C1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)30-15-16-42(22-30)20-24-7-11-26(12-8-24)27-13-9-25(10-14-27)23-44-33-6-4-5-32(33)39-35(43)31-17-28(18-37-34(31)36)29-19-38-41(3)21-29/h7-14,17-19,21,30,32-33H,4-6,15-16,20,22-23H2,1-3H3,(H2,36,37)(H,39,43)/t30?,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298791
PNG
(US10125118, Example 197 | US10947215, Example 197)
Show SMILES CN1CCN(Cc2ccc(cc2C(F)(F)F)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C35H40F3N7O2/c1-43-12-14-45(15-13-43)21-26-11-10-25(17-30(26)35(36,37)38)24-8-6-23(7-9-24)22-47-32-5-3-4-31(32)42-34(46)29-16-27(18-40-33(29)39)28-19-41-44(2)20-28/h6-11,16-20,31-32H,3-5,12-15,21-22H2,1-2H3,(H2,39,40)(H,42,46)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298798
PNG
(US10125118, Example 204 | US10947215, Example 204)
Show SMILES CN1CCN(Cc2ccc(nc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C33H40N8O2/c1-39-12-14-41(15-13-39)20-24-8-11-29(35-17-24)25-9-6-23(7-10-25)22-43-31-5-3-4-30(31)38-33(42)28-16-26(18-36-32(28)34)27-19-37-40(2)21-27/h6-11,16-19,21,30-31H,3-5,12-15,20,22H2,1-2H3,(H2,34,36)(H,38,42)/t30-,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298800
PNG
(US10125118, Example 206 | US10947215, Example 206)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCN(CCO)CC2)cc1Cl
Show InChI InChI=1S/C35H42ClN7O3/c1-41-22-28(20-39-41)27-18-30(34(37)38-19-27)35(45)40-32-3-2-4-33(32)46-23-24-5-8-26(9-6-24)29-10-7-25(17-31(29)36)21-43-13-11-42(12-14-43)15-16-44/h5-10,17-20,22,32-33,44H,2-4,11-16,21,23H2,1H3,(H2,37,38)(H,40,45)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298806
PNG
(US10125118, Example 212 | US10947215, Example 212)
Show SMILES CC(N1CCN(CCO)CC1)c1c(F)cc(cc1F)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C36H43F2N7O3/c1-23(45-12-10-44(11-13-45)14-15-46)34-30(37)17-26(18-31(34)38)25-8-6-24(7-9-25)22-48-33-5-3-4-32(33)42-36(47)29-16-27(19-40-35(29)39)28-20-41-43(2)21-28/h6-9,16-21,23,32-33,46H,3-5,10-15,22H2,1-2H3,(H2,39,40)(H,42,47)/t23?,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
recombinant proteins of human c-MER and AXL catalytic domains


(Homo sapiens (Human))
BDBM298809
PNG
(US10125118, Example 215 | US10947215, Example 215)
Show SMILES C[C@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C35H43N7O2/c1-24(42-17-15-40(2)16-18-42)26-11-13-28(14-12-26)27-9-7-25(8-10-27)23-44-33-6-4-5-32(33)39-35(43)31-19-29(20-37-34(31)36)30-21-38-41(3)22-30/h7-14,19-22,24,32-33H,4-6,15-18,23H2,1-3H3,(H2,36,37)(H,39,43)/t24-,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...


US Patent US10947215 (2021)

More data for this
Ligand-Target Pair
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